

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | reproduction (GO:0000003) | 9.73209692 |
| 2 | spermatid development (GO:0007286) | 9.46246262 |
| 3 | axonemal dynein complex assembly (GO:0070286) | 9.12163584 |
| 4 | epithelial cilium movement (GO:0003351) | 9.05247122 |
| 5 | motile cilium assembly (GO:0044458) | 8.94715601 |
| 6 | cilium or flagellum-dependent cell motility (GO:0001539) | 8.63367827 |
| 7 | regulation of cilium movement (GO:0003352) | 7.86212270 |
| 8 | cilium movement (GO:0003341) | 7.53494259 |
| 9 | sperm capacitation (GO:0048240) | 7.46946819 |
| 10 | single fertilization (GO:0007338) | 7.24476601 |
| 11 | synaptonemal complex assembly (GO:0007130) | 7.07740829 |
| 12 | synaptonemal complex organization (GO:0070193) | 7.01425913 |
| 13 | male meiosis (GO:0007140) | 6.99796311 |
| 14 | negative regulation of inclusion body assembly (GO:0090084) | 6.79790199 |
| 15 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.78501443 |
| 16 | organic cation transport (GO:0015695) | 6.66589344 |
| 17 | spermatogenesis (GO:0007283) | 6.56899364 |
| 18 | male gamete generation (GO:0048232) | 6.54379753 |
| 19 | spermatid nucleus differentiation (GO:0007289) | 6.19516280 |
| 20 | piRNA metabolic process (GO:0034587) | 6.17104355 |
| 21 | fertilization (GO:0009566) | 6.06817146 |
| 22 | gamete generation (GO:0007276) | 6.01656023 |
| 23 | microtubule depolymerization (GO:0007019) | 5.96875713 |
| 24 | calcium ion-dependent exocytosis (GO:0017156) | 5.95352314 |
| 25 | regulation of inclusion body assembly (GO:0090083) | 5.72390548 |
| 26 | cell recognition (GO:0008037) | 5.44759783 |
| 27 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 5.39941900 |
| 28 | chromosome condensation (GO:0030261) | 5.28449949 |
| 29 | microtubule severing (GO:0051013) | 5.28143939 |
| 30 | germ cell development (GO:0007281) | 5.22368572 |
| 31 | ventricular system development (GO:0021591) | 5.10593065 |
| 32 | DNA packaging (GO:0006323) | 5.01099195 |
| 33 | response to pheromone (GO:0019236) | 4.99330001 |
| 34 | chromosome organization involved in meiosis (GO:0070192) | 4.73245110 |
| 35 | multicellular organismal reproductive process (GO:0048609) | 4.71337199 |
| 36 | regulation of microtubule-based movement (GO:0060632) | 4.65648060 |
| 37 | glycerol ether metabolic process (GO:0006662) | 4.47317693 |
| 38 | seminiferous tubule development (GO:0072520) | 4.28926377 |
| 39 | sexual reproduction (GO:0019953) | 4.28035278 |
| 40 | male meiosis I (GO:0007141) | 4.19676165 |
| 41 | ether metabolic process (GO:0018904) | 4.13218466 |
| 42 | DNA methylation involved in gamete generation (GO:0043046) | 4.08088477 |
| 43 | behavioral response to nicotine (GO:0035095) | 4.07703664 |
| 44 | cellular ketone body metabolic process (GO:0046950) | 4.05596524 |
| 45 | meiotic nuclear division (GO:0007126) | 4.03399007 |
| 46 | single strand break repair (GO:0000012) | 4.02923507 |
| 47 | sequestering of actin monomers (GO:0042989) | 3.98600335 |
| 48 | chaperone-mediated protein complex assembly (GO:0051131) | 3.91782174 |
| 49 | protein polyglutamylation (GO:0018095) | 3.90421454 |
| 50 | platelet dense granule organization (GO:0060155) | 3.85240474 |
| 51 | ketone body metabolic process (GO:1902224) | 3.82767809 |
| 52 | multicellular organismal development (GO:0007275) | 3.80314389 |
| 53 | left/right pattern formation (GO:0060972) | 3.75898439 |
| 54 | positive regulation of macrophage activation (GO:0043032) | 3.72086187 |
| 55 | negative regulation of telomere maintenance (GO:0032205) | 3.70184212 |
| 56 | L-fucose catabolic process (GO:0042355) | 3.65667954 |
| 57 | fucose catabolic process (GO:0019317) | 3.65667954 |
| 58 | L-fucose metabolic process (GO:0042354) | 3.65667954 |
| 59 | indolalkylamine metabolic process (GO:0006586) | 3.60001647 |
| 60 | protein K11-linked deubiquitination (GO:0035871) | 3.53197768 |
| 61 | DNA deamination (GO:0045006) | 3.46526495 |
| 62 | tryptophan catabolic process (GO:0006569) | 3.37940246 |
| 63 | indole-containing compound catabolic process (GO:0042436) | 3.37940246 |
| 64 | indolalkylamine catabolic process (GO:0046218) | 3.37940246 |
| 65 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.36233865 |
| 66 | detection of light stimulus involved in visual perception (GO:0050908) | 3.36233865 |
| 67 | adaptation of signaling pathway (GO:0023058) | 3.35726034 |
| 68 | meiosis I (GO:0007127) | 3.29079359 |
| 69 | regulation of spindle checkpoint (GO:0090231) | 3.26054651 |
| 70 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.23850007 |
| 71 | negative regulation of mast cell activation (GO:0033004) | 3.23147970 |
| 72 | genitalia morphogenesis (GO:0035112) | 3.22705489 |
| 73 | amino-acid betaine transport (GO:0015838) | 3.21262484 |
| 74 | carnitine transport (GO:0015879) | 3.21262484 |
| 75 | tryptophan metabolic process (GO:0006568) | 3.20469371 |
| 76 | nonmotile primary cilium assembly (GO:0035058) | 3.17110606 |
| 77 | protein localization to cilium (GO:0061512) | 3.15785989 |
| 78 | protein complex biogenesis (GO:0070271) | 3.15073288 |
| 79 | microtubule polymerization or depolymerization (GO:0031109) | 3.14224964 |
| 80 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.13541604 |
| 81 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.09522929 |
| 82 | carnitine transmembrane transport (GO:1902603) | 3.06291780 |
| 83 | kynurenine metabolic process (GO:0070189) | 3.00814589 |
| 84 | mannosylation (GO:0097502) | 2.99203423 |
| 85 | ubiquinone biosynthetic process (GO:0006744) | 2.96668999 |
| 86 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.96020553 |
| 87 | nucleus organization (GO:0006997) | 2.94826698 |
| 88 | protein-cofactor linkage (GO:0018065) | 2.94784884 |
| 89 | respiratory chain complex IV assembly (GO:0008535) | 2.94709138 |
| 90 | interferon-gamma secretion (GO:0072643) | 2.93538808 |
| 91 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.89026185 |
| 92 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.86344503 |
| 93 | protein refolding (GO:0042026) | 2.85126248 |
| 94 | regulation of meiosis I (GO:0060631) | 2.84891905 |
| 95 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.84395356 |
| 96 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.84395356 |
| 97 | NADH dehydrogenase complex assembly (GO:0010257) | 2.84395356 |
| 98 | ubiquinone metabolic process (GO:0006743) | 2.83282811 |
| 99 | cornea development in camera-type eye (GO:0061303) | 2.82608311 |
| 100 | inositol phosphate catabolic process (GO:0071545) | 2.81022176 |
| 101 | meiotic cell cycle (GO:0051321) | 2.79252043 |
| 102 | cytochrome complex assembly (GO:0017004) | 2.77522902 |
| 103 | indole-containing compound metabolic process (GO:0042430) | 2.77129728 |
| 104 | glycolytic process (GO:0006096) | 2.74929666 |
| 105 | synapsis (GO:0007129) | 2.74451669 |
| 106 | dopamine transport (GO:0015872) | 2.74308932 |
| 107 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.73971103 |
| 108 | cilium organization (GO:0044782) | 2.72973925 |
| 109 | cellular component assembly involved in morphogenesis (GO:0010927) | 2.72393181 |
| 110 | amine catabolic process (GO:0009310) | 2.72015459 |
| 111 | cellular biogenic amine catabolic process (GO:0042402) | 2.72015459 |
| 112 | regulation of telomere maintenance (GO:0032204) | 2.71562768 |
| 113 | microtubule-based movement (GO:0007018) | 2.69035082 |
| 114 | photoreceptor cell maintenance (GO:0045494) | 2.68736866 |
| 115 | cullin deneddylation (GO:0010388) | 2.68253744 |
| 116 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.67565043 |
| 117 | polyol catabolic process (GO:0046174) | 2.66905237 |
| 118 | behavioral response to ethanol (GO:0048149) | 2.65740514 |
| 119 | polyamine biosynthetic process (GO:0006596) | 2.64986692 |
| 120 | RNA localization (GO:0006403) | 2.64187182 |
| 121 | cilium morphogenesis (GO:0060271) | 2.62856430 |
| 122 | negative regulation of organelle assembly (GO:1902116) | 2.62706382 |
| 123 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.62705617 |
| 124 | chromatin silencing (GO:0006342) | 2.62608176 |
| 125 | cilium assembly (GO:0042384) | 2.60861854 |
| 126 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.58320747 |
| 127 | intraciliary transport (GO:0042073) | 2.57406524 |
| 128 | peptidyl-histidine modification (GO:0018202) | 2.57144939 |
| 129 | regulation of cilium assembly (GO:1902017) | 2.56470793 |
| 130 | axoneme assembly (GO:0035082) | 2.56118308 |
| 131 | peptidyl-glutamic acid modification (GO:0018200) | 2.56017518 |
| 132 | RNA destabilization (GO:0050779) | 2.55801004 |
| 133 | glycosphingolipid biosynthetic process (GO:0006688) | 2.55550186 |
| 134 | calcium ion import (GO:0070509) | 2.55474762 |
| 135 | GPI anchor metabolic process (GO:0006505) | 2.54347487 |
| 136 | meiotic cell cycle process (GO:1903046) | 2.54321107 |
| 137 | photoreceptor cell development (GO:0042461) | 2.52288705 |
| 138 | protein deneddylation (GO:0000338) | 2.52069255 |
| 139 | positive regulation of prostaglandin secretion (GO:0032308) | 2.51424319 |
| 140 | S-adenosylmethionine metabolic process (GO:0046500) | 2.50229079 |
| 141 | centriole assembly (GO:0098534) | 2.49891201 |
| 142 | alditol metabolic process (GO:0019400) | 2.49324510 |
| 143 | retinal cone cell development (GO:0046549) | 2.48587150 |
| 144 | synaptic transmission, cholinergic (GO:0007271) | 2.47847104 |
| 145 | mitotic sister chromatid cohesion (GO:0007064) | 2.46908133 |
| 146 | auditory receptor cell stereocilium organization (GO:0060088) | 2.46434231 |
| 147 | nucleobase catabolic process (GO:0046113) | 2.45210781 |
| 148 | regulation of collateral sprouting (GO:0048670) | 2.44517356 |
| 149 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.43990952 |
| 150 | neural tube formation (GO:0001841) | 2.43657364 |
| 151 | rRNA catabolic process (GO:0016075) | 2.43116247 |
| 152 | proline transport (GO:0015824) | 2.42827909 |
| 153 | glycerophospholipid catabolic process (GO:0046475) | 2.41156494 |
| 154 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.40850339 |
| 155 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.40850339 |
| 156 | cAMP catabolic process (GO:0006198) | 2.40758755 |
| 157 | inositol phosphate dephosphorylation (GO:0046855) | 2.40553023 |
| 158 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 2.40553023 |
| 159 | protein neddylation (GO:0045116) | 2.39937977 |
| 160 | quinone biosynthetic process (GO:1901663) | 2.39600528 |
| 161 | centriole replication (GO:0007099) | 2.39151763 |
| 162 | protein-DNA complex disassembly (GO:0032986) | 2.31806901 |
| 163 | nucleosome disassembly (GO:0006337) | 2.31806901 |
| 164 | membrane depolarization during action potential (GO:0086010) | 2.30385731 |
| 165 | cell wall macromolecule metabolic process (GO:0044036) | 16.0111040 |
| 166 | cell wall macromolecule catabolic process (GO:0016998) | 16.0111040 |
| 167 | fusion of sperm to egg plasma membrane (GO:0007342) | 13.4298005 |
| 168 | sperm motility (GO:0030317) | 13.1846026 |
| 169 | acrosome assembly (GO:0001675) | 13.1170900 |
| 170 | acrosome reaction (GO:0007340) | 12.2680391 |
| 171 | sperm-egg recognition (GO:0035036) | 12.1925780 |
| 172 | multicellular organism reproduction (GO:0032504) | 11.2897381 |
| 173 | cell-cell recognition (GO:0009988) | 10.9266629 |
| 174 | binding of sperm to zona pellucida (GO:0007339) | 10.7394762 |
| 175 | plasma membrane fusion (GO:0045026) | 10.2745634 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 8.57098496 |
| 2 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.38017300 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.96416431 |
| 4 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.34083456 |
| 5 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.96287194 |
| 6 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.89687129 |
| 7 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.84226547 |
| 8 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.56781051 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.50166542 |
| 10 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.43709309 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.29652953 |
| 12 | FUS_26573619_Chip-Seq_HEK293_Human | 2.28785618 |
| 13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.28074485 |
| 14 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.23081206 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.18260992 |
| 16 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.16798701 |
| 17 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 2.14226167 |
| 18 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.10311715 |
| 19 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.09810163 |
| 20 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 2.08813374 |
| 21 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 2.03269319 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.03027150 |
| 23 | P300_19829295_ChIP-Seq_ESCs_Human | 1.99762122 |
| 24 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.99223338 |
| 25 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.96699835 |
| 26 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.96335993 |
| 27 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.89100150 |
| 28 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.83461705 |
| 29 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.81029938 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.81020005 |
| 31 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.75173513 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74730324 |
| 33 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.74419151 |
| 34 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.74303344 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.72162690 |
| 36 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.70214962 |
| 37 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.67888503 |
| 38 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.64590903 |
| 39 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.63986713 |
| 40 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.63791114 |
| 41 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.61712859 |
| 42 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.59786295 |
| 43 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.58493639 |
| 44 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.56210060 |
| 45 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.55771303 |
| 46 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.54803020 |
| 47 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53551845 |
| 48 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.52578456 |
| 49 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.51324562 |
| 50 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.49710558 |
| 51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.49390514 |
| 52 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.49086338 |
| 53 | * KDM2B_26808549_Chip-Seq_REH_Human | 1.47747895 |
| 54 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.47006122 |
| 55 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.46931684 |
| 56 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.46525328 |
| 57 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.46072478 |
| 58 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.46072478 |
| 59 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.45426808 |
| 60 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.44279204 |
| 61 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.43737119 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.43718006 |
| 63 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.43129389 |
| 64 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.42282655 |
| 65 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.41512717 |
| 66 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.41512717 |
| 67 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 1.41490715 |
| 68 | STAT3_23295773_ChIP-Seq_U87_Human | 1.40837766 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.39158670 |
| 70 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.38776878 |
| 71 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.38225947 |
| 72 | NCOR_22424771_ChIP-Seq_293T_Human | 1.38127994 |
| 73 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.35292637 |
| 74 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.33712176 |
| 75 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.32183732 |
| 76 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.31902949 |
| 77 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.30786554 |
| 78 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.30231713 |
| 79 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.29488958 |
| 80 | TCF4_23295773_ChIP-Seq_U87_Human | 1.29144259 |
| 81 | GF1_26923725_Chip-Seq_HPCs_Mouse | 1.28215824 |
| 82 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.28138176 |
| 83 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.27916034 |
| 84 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.27769832 |
| 85 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.27353004 |
| 86 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.26853565 |
| 87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.26853565 |
| 88 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 1.26708694 |
| 89 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.26378735 |
| 90 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.25794836 |
| 91 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.24015759 |
| 92 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.22949224 |
| 93 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.20678127 |
| 94 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.20209088 |
| 95 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.19588143 |
| 96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.19569748 |
| 97 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.19243903 |
| 98 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.18587048 |
| 99 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.18278787 |
| 100 | CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.17647633 |
| 101 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.17591057 |
| 102 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.17289907 |
| 103 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.16802912 |
| 104 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.16541241 |
| 105 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.15691104 |
| 106 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.15565987 |
| 107 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.15339735 |
| 108 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.15246639 |
| 109 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.13603201 |
| 110 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.13363015 |
| 111 | AR_20517297_ChIP-Seq_VCAP_Human | 1.13204040 |
| 112 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 1.13114203 |
| 113 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.12631943 |
| 114 | ERA_21632823_ChIP-Seq_H3396_Human | 1.09484655 |
| 115 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 1.09443407 |
| 116 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.09336643 |
| 117 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.08949001 |
| 118 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.08646086 |
| 119 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 1.08590753 |
| 120 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.08364227 |
| 121 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.08049684 |
| 122 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.07552090 |
| 123 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.07347141 |
| 124 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07347141 |
| 125 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07070695 |
| 126 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.06946835 |
| 127 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06839628 |
| 128 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.05618160 |
| 129 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05208670 |
| 130 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05193280 |
| 131 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.05188111 |
| 132 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.04446341 |
| 133 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.04240835 |
| 134 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 1.03702739 |
| 135 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 1.03545480 |
| 136 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.03371801 |
| 137 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.03150573 |
| 138 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.02956108 |
| 139 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.02499946 |
| 140 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.01570282 |
| 141 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.01513484 |
| 142 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.99791136 |
| 143 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.99414932 |
| 144 | LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.99169205 |
| 145 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.98900132 |
| 146 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.98718914 |
| 147 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.98352326 |
| 148 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.98089662 |
| 149 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98067054 |
| 150 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.97696504 |
| 151 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.96659471 |
| 152 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.96556828 |
| 153 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.96147066 |
| 154 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.96117123 |
| 155 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.95813231 |
| 156 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.95745736 |
| 157 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.95039222 |
| 158 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.94409292 |
| 159 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.94161609 |
| 160 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.93611208 |
| 161 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.93067516 |
| 162 | GF1B_26923725_Chip-Seq_HPCs_Mouse | 0.92745576 |
| 163 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.92422356 |
| 164 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.92324798 |
| 165 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.92303609 |
| 166 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.91194111 |
| 167 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.90193647 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003698_abnormal_male_reproductive | 5.99471053 |
| 2 | MP0001929_abnormal_gametogenesis | 5.44901232 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.82193292 |
| 4 | MP0002210_abnormal_sex_determination | 3.24128898 |
| 5 | MP0002161_abnormal_fertility/fecundity | 3.21693365 |
| 6 | MP0001986_abnormal_taste_sensitivity | 2.85724302 |
| 7 | MP0001145_abnormal_male_reproductive | 2.81016135 |
| 8 | MP0000372_irregular_coat_pigmentation | 2.67211168 |
| 9 | MP0005670_abnormal_white_adipose | 2.54173044 |
| 10 | MP0002653_abnormal_ependyma_morphology | 2.53983509 |
| 11 | MP0000653_abnormal_sex_gland | 2.43972056 |
| 12 | MP0003195_calcinosis | 2.41237794 |
| 13 | MP0004147_increased_porphyrin_level | 2.29227892 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 2.12770841 |
| 15 | MP0005645_abnormal_hypothalamus_physiol | 2.10830495 |
| 16 | MP0005410_abnormal_fertilization | 16.4354442 |
| 17 | MP0006292_abnormal_olfactory_placode | 1.95053124 |
| 18 | MP0005171_absent_coat_pigmentation | 1.94395500 |
| 19 | MP0004233_abnormal_muscle_weight | 1.93663255 |
| 20 | MP0003136_yellow_coat_color | 1.91640970 |
| 21 | MP0006072_abnormal_retinal_apoptosis | 1.88572817 |
| 22 | MP0003880_abnormal_central_pattern | 1.88457580 |
| 23 | MP0005646_abnormal_pituitary_gland | 1.85817114 |
| 24 | MP0000427_abnormal_hair_cycle | 1.82172157 |
| 25 | MP0001501_abnormal_sleep_pattern | 1.81104497 |
| 26 | MP0008789_abnormal_olfactory_epithelium | 1.78535242 |
| 27 | MP0001529_abnormal_vocalization | 1.76576284 |
| 28 | MP0006276_abnormal_autonomic_nervous | 1.76368116 |
| 29 | MP0002876_abnormal_thyroid_physiology | 1.74689571 |
| 30 | MP0005623_abnormal_meninges_morphology | 1.70951208 |
| 31 | MP0003646_muscle_fatigue | 1.68628166 |
| 32 | MP0002160_abnormal_reproductive_system | 1.65917321 |
| 33 | MP0002638_abnormal_pupillary_reflex | 1.65054316 |
| 34 | MP0002938_white_spotting | 1.59354600 |
| 35 | MP0009046_muscle_twitch | 1.58279030 |
| 36 | MP0000631_abnormal_neuroendocrine_gland | 1.50677442 |
| 37 | MP0002095_abnormal_skin_pigmentation | 1.47945768 |
| 38 | MP0004142_abnormal_muscle_tone | 1.47686633 |
| 39 | MP0000015_abnormal_ear_pigmentation | 1.46036419 |
| 40 | MP0005379_endocrine/exocrine_gland_phen | 1.39245906 |
| 41 | MP0001984_abnormal_olfaction | 1.36471984 |
| 42 | MP0003718_maternal_effect | 1.35469011 |
| 43 | MP0001905_abnormal_dopamine_level | 1.35357237 |
| 44 | MP0005174_abnormal_tail_pigmentation | 1.34719325 |
| 45 | MP0008875_abnormal_xenobiotic_pharmacok | 1.32849453 |
| 46 | MP0002163_abnormal_gland_morphology | 1.25480738 |
| 47 | MP0002234_abnormal_pharynx_morphology | 1.25453264 |
| 48 | MP0005394_taste/olfaction_phenotype | 1.25102323 |
| 49 | MP0005499_abnormal_olfactory_system | 1.25102323 |
| 50 | MP0005075_abnormal_melanosome_morpholog | 1.23774110 |
| 51 | MP0001485_abnormal_pinna_reflex | 1.08692738 |
| 52 | MP0002751_abnormal_autonomic_nervous | 1.03994267 |
| 53 | MP0001765_abnormal_ion_homeostasis | 1.00416794 |
| 54 | MP0001919_abnormal_reproductive_system | 1.00114414 |
| 55 | MP0004924_abnormal_behavior | 0.99292939 |
| 56 | MP0005386_behavior/neurological_phenoty | 0.99292939 |
| 57 | MP0003121_genomic_imprinting | 0.97686616 |
| 58 | MP0001188_hyperpigmentation | 0.96118754 |
| 59 | MP0002282_abnormal_trachea_morphology | 0.95499368 |
| 60 | MP0002735_abnormal_chemical_nociception | 0.95228968 |
| 61 | MP0004885_abnormal_endolymph | 0.94436103 |
| 62 | MP0010386_abnormal_urinary_bladder | 0.93492670 |
| 63 | MP0001970_abnormal_pain_threshold | 0.91184114 |
| 64 | MP0005084_abnormal_gallbladder_morpholo | 0.90354533 |
| 65 | MP0003786_premature_aging | 0.88213740 |
| 66 | MP0005085_abnormal_gallbladder_physiolo | 0.84743887 |
| 67 | MP0008058_abnormal_DNA_repair | 0.83663341 |
| 68 | MP0000647_abnormal_sebaceous_gland | 0.82405041 |
| 69 | MP0000026_abnormal_inner_ear | 0.80853642 |
| 70 | MP0002184_abnormal_innervation | 0.79723509 |
| 71 | MP0005389_reproductive_system_phenotype | 0.79354734 |
| 72 | MP0002733_abnormal_thermal_nociception | 0.79335822 |
| 73 | MP0005332_abnormal_amino_acid | 0.77618604 |
| 74 | MP0002254_reproductive_system_inflammat | 0.76183257 |
| 75 | MP0005647_abnormal_sex_gland | 0.74768946 |
| 76 | MP0003329_amyloid_beta_deposits | 0.64492973 |
| 77 | MP0003633_abnormal_nervous_system | 0.62701128 |
| 78 | MP0004270_analgesia | 0.60318631 |
| 79 | MP0003950_abnormal_plasma_membrane | 0.60001273 |
| 80 | MP0004036_abnormal_muscle_relaxation | 0.57609909 |
| 81 | MP0002736_abnormal_nociception_after | 0.56966863 |
| 82 | MP0003115_abnormal_respiratory_system | 0.56826383 |
| 83 | MP0003635_abnormal_synaptic_transmissio | 0.54315994 |
| 84 | MP0003011_delayed_dark_adaptation | 0.53817352 |
| 85 | MP0004859_abnormal_synaptic_plasticity | 0.53813173 |
| 86 | MP0004811_abnormal_neuron_physiology | 0.52449110 |
| 87 | MP0001968_abnormal_touch/_nociception | 0.51096735 |
| 88 | MP0002102_abnormal_ear_morphology | 0.49424810 |
| 89 | MP0002822_catalepsy | 0.48726839 |
| 90 | MP0002269_muscular_atrophy | 0.48358389 |
| 91 | MP0005636_abnormal_mineral_homeostasis | 0.47987554 |
| 92 | MP0003699_abnormal_female_reproductive | 0.47780178 |
| 93 | MP0005551_abnormal_eye_electrophysiolog | 0.47221598 |
| 94 | MP0006036_abnormal_mitochondrial_physio | 0.46624814 |
| 95 | MP0004133_heterotaxia | 0.46565321 |
| 96 | MP0003787_abnormal_imprinting | 0.46561917 |
| 97 | MP0003631_nervous_system_phenotype | 0.45840046 |
| 98 | MP0002928_abnormal_bile_duct | 0.45002975 |
| 99 | MP0002572_abnormal_emotion/affect_behav | 0.44899229 |
| 100 | MP0001324_abnormal_eye_pigmentation | 0.43061824 |
| 101 | MP0001293_anophthalmia | 0.40992366 |
| 102 | MP0002063_abnormal_learning/memory/cond | 0.40080316 |
| 103 | MP0005253_abnormal_eye_physiology | 0.40023243 |
| 104 | MP0002909_abnormal_adrenal_gland | 0.39641237 |
| 105 | MP0009745_abnormal_behavioral_response | 0.38356618 |
| 106 | MP0005666_abnormal_adipose_tissue | 0.37516830 |
| 107 | MP0002152_abnormal_brain_morphology | 0.37202590 |
| 108 | MP0000358_abnormal_cell_content/ | 0.35507684 |
| 109 | MP0008569_lethality_at_weaning | 0.35212313 |
| 110 | MP0008995_early_reproductive_senescence | 0.32547164 |
| 111 | MP0002272_abnormal_nervous_system | 0.32331060 |
| 112 | MP0002064_seizures | 0.31931942 |
| 113 | MP0003861_abnormal_nervous_system | 0.31925706 |
| 114 | MP0000534_abnormal_ureter_morphology | 0.29818610 |
| 115 | MP0000569_abnormal_digit_pigmentation | 0.28772255 |
| 116 | MP0000604_amyloidosis | 0.28693620 |
| 117 | MP0002229_neurodegeneration | 0.28684485 |
| 118 | MP0005423_abnormal_somatic_nervous | 0.28517337 |
| 119 | MP0003879_abnormal_hair_cell | 0.28264846 |
| 120 | MP0001764_abnormal_homeostasis | 0.27397133 |
| 121 | MP0001486_abnormal_startle_reflex | 0.26196187 |
| 122 | MP0002557_abnormal_social/conspecific_i | 0.25626321 |
| 123 | MP0005391_vision/eye_phenotype | 0.25603454 |
| 124 | MP0009115_abnormal_fat_cell | 0.25483799 |
| 125 | MP0003878_abnormal_ear_physiology | 0.25146949 |
| 126 | MP0005377_hearing/vestibular/ear_phenot | 0.25146949 |
| 127 | MP0004145_abnormal_muscle_electrophysio | 0.24763429 |
| 128 | MP0002169_no_abnormal_phenotype | 0.23851933 |
| 129 | MP0006035_abnormal_mitochondrial_morpho | 0.23843958 |
| 130 | MP0002873_normal_phenotype | 0.23747008 |
| 131 | MP0001440_abnormal_grooming_behavior | 0.23210309 |
| 132 | MP0002734_abnormal_mechanical_nocicepti | 0.22616924 |
| 133 | MP0008872_abnormal_physiological_respon | 0.22253449 |
| 134 | MP0002882_abnormal_neuron_morphology | 0.21408912 |
| 135 | MP0010094_abnormal_chromosome_stability | 0.21097757 |
| 136 | MP0001730_embryonic_growth_arrest | 0.20758503 |
| 137 | MP0004019_abnormal_vitamin_homeostasis | 0.20381714 |
| 138 | MP0004043_abnormal_pH_regulation | 0.20288989 |
| 139 | MP0003948_abnormal_gas_homeostasis | 0.19980618 |
| 140 | MP0001545_abnormal_hematopoietic_system | 0.19954118 |
| 141 | MP0005397_hematopoietic_system_phenotyp | 0.19954118 |
| 142 | MP0000955_abnormal_spinal_cord | 0.19881713 |
| 143 | MP0002752_abnormal_somatic_nervous | 0.19139664 |
| 144 | MP0000920_abnormal_myelination | 0.19066763 |
| 145 | MP0003634_abnormal_glial_cell | 0.19058646 |
| 146 | MP0002066_abnormal_motor_capabilities/c | 0.18915612 |
| 147 | MP0002971_abnormal_brown_adipose | 0.18442818 |
| 148 | MP0005195_abnormal_posterior_eye | 0.18218095 |
| 149 | MP0001119_abnormal_female_reproductive | 0.18161719 |
| 150 | MP0010307_abnormal_tumor_latency | 0.17854463 |
| 151 | MP0005535_abnormal_body_temperature | 0.17530407 |
| 152 | MP0003942_abnormal_urinary_system | 0.17373374 |
| 153 | MP0004742_abnormal_vestibular_system | 0.16499767 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal respiratory motile cilium physiology (HP:0012261) | 9.44649851 |
| 2 | Abnormal respiratory epithelium morphology (HP:0012253) | 8.80596372 |
| 3 | Abnormal respiratory motile cilium morphology (HP:0005938) | 8.80596372 |
| 4 | Rhinitis (HP:0012384) | 7.75928058 |
| 5 | Abnormal ciliary motility (HP:0012262) | 7.51065091 |
| 6 | Chronic bronchitis (HP:0004469) | 7.37610053 |
| 7 | Infertility (HP:0000789) | 6.70918996 |
| 8 | Nasal polyposis (HP:0100582) | 6.41569276 |
| 9 | Abnormality of the nasal mucosa (HP:0000433) | 5.25818653 |
| 10 | Bronchitis (HP:0012387) | 4.51866078 |
| 11 | Bronchiectasis (HP:0002110) | 4.47870623 |
| 12 | Male infertility (HP:0003251) | 4.42560349 |
| 13 | Pancreatic cysts (HP:0001737) | 4.15374096 |
| 14 | Nephronophthisis (HP:0000090) | 4.10286274 |
| 15 | Congenital stationary night blindness (HP:0007642) | 4.00604185 |
| 16 | True hermaphroditism (HP:0010459) | 3.67875082 |
| 17 | Abnormal spermatogenesis (HP:0008669) | 3.67697773 |
| 18 | Recurrent otitis media (HP:0000403) | 3.23245239 |
| 19 | Recurrent sinusitis (HP:0011108) | 3.18733460 |
| 20 | Medial flaring of the eyebrow (HP:0010747) | 3.12503909 |
| 21 | Chronic hepatic failure (HP:0100626) | 3.07603805 |
| 22 | Pendular nystagmus (HP:0012043) | 3.05400451 |
| 23 | Acute necrotizing encephalopathy (HP:0006965) | 3.04566006 |
| 24 | Attenuation of retinal blood vessels (HP:0007843) | 3.02604629 |
| 25 | Abnormality of the renal medulla (HP:0100957) | 3.01918042 |
| 26 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.00304533 |
| 27 | Abnormality of midbrain morphology (HP:0002418) | 2.83881364 |
| 28 | Molar tooth sign on MRI (HP:0002419) | 2.83881364 |
| 29 | Hypothermia (HP:0002045) | 2.77777844 |
| 30 | Mitochondrial inheritance (HP:0001427) | 2.70925072 |
| 31 | Abnormality of macular pigmentation (HP:0008002) | 2.70658874 |
| 32 | Tubular atrophy (HP:0000092) | 2.68304208 |
| 33 | Azoospermia (HP:0000027) | 2.66701176 |
| 34 | Progressive macrocephaly (HP:0004481) | 2.64272868 |
| 35 | Abolished electroretinogram (ERG) (HP:0000550) | 2.63370599 |
| 36 | Acute encephalopathy (HP:0006846) | 2.61940676 |
| 37 | Increased CSF lactate (HP:0002490) | 2.61404224 |
| 38 | Recurrent bronchitis (HP:0002837) | 2.61370095 |
| 39 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.57044858 |
| 40 | Sclerocornea (HP:0000647) | 2.45394938 |
| 41 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.43335319 |
| 42 | Tubulointerstitial nephritis (HP:0001970) | 2.41833553 |
| 43 | Lipid accumulation in hepatocytes (HP:0006561) | 2.41091029 |
| 44 | Tubulointerstitial abnormality (HP:0001969) | 2.38475054 |
| 45 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.37400698 |
| 46 | Intestinal atresia (HP:0011100) | 2.35480748 |
| 47 | Anencephaly (HP:0002323) | 2.30918972 |
| 48 | Impulsivity (HP:0100710) | 2.28751567 |
| 49 | Severe visual impairment (HP:0001141) | 2.24566921 |
| 50 | Increased hepatocellular lipid droplets (HP:0006565) | 2.24519696 |
| 51 | Hyperventilation (HP:0002883) | 2.21314473 |
| 52 | Hyperglycinemia (HP:0002154) | 2.20543581 |
| 53 | 3-Methylglutaconic aciduria (HP:0003535) | 2.19165487 |
| 54 | Tubulointerstitial fibrosis (HP:0005576) | 2.17322398 |
| 55 | Optic disc pallor (HP:0000543) | 2.16823531 |
| 56 | Broad-based gait (HP:0002136) | 2.15967881 |
| 57 | Hepatocellular necrosis (HP:0001404) | 2.15370026 |
| 58 | Lissencephaly (HP:0001339) | 2.15210173 |
| 59 | Hepatic necrosis (HP:0002605) | 2.15055225 |
| 60 | Renal cortical cysts (HP:0000803) | 2.14640490 |
| 61 | Cholecystitis (HP:0001082) | 2.11553851 |
| 62 | Abnormal gallbladder physiology (HP:0012438) | 2.11553851 |
| 63 | Hypoplasia of the fovea (HP:0007750) | 2.09234243 |
| 64 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.09234243 |
| 65 | Occipital encephalocele (HP:0002085) | 2.05303689 |
| 66 | Male pseudohermaphroditism (HP:0000037) | 2.03243132 |
| 67 | Congenital sensorineural hearing impairment (HP:0008527) | 2.02564095 |
| 68 | Dyschromatopsia (HP:0007641) | 2.02297261 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.00010694 |
| 70 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 13.4739460 |
| 71 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 12.5067310 |
| 72 | Absent/shortened dynein arms (HP:0200106) | 12.5067310 |
| 73 | Decreased central vision (HP:0007663) | 1.99212364 |
| 74 | Polydipsia (HP:0001959) | 1.98300715 |
| 75 | Abnormal drinking behavior (HP:0030082) | 1.98300715 |
| 76 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.97716415 |
| 77 | Abnormality of alanine metabolism (HP:0010916) | 1.97716415 |
| 78 | Hyperalaninemia (HP:0003348) | 1.97716415 |
| 79 | Inability to walk (HP:0002540) | 1.96695656 |
| 80 | Keratoconus (HP:0000563) | 1.96557298 |
| 81 | Increased corneal curvature (HP:0100692) | 1.96557298 |
| 82 | Increased serum lactate (HP:0002151) | 1.96296591 |
| 83 | Renal Fanconi syndrome (HP:0001994) | 1.94457669 |
| 84 | Abnormality of saccadic eye movements (HP:0000570) | 1.93181375 |
| 85 | Gait imbalance (HP:0002141) | 1.91563187 |
| 86 | Hypokalemic alkalosis (HP:0001949) | 1.90995429 |
| 87 | Absent speech (HP:0001344) | 1.90890994 |
| 88 | Pachygyria (HP:0001302) | 1.90616283 |
| 89 | Abnormality of the fovea (HP:0000493) | 1.90247218 |
| 90 | Congenital malformation of the right heart (HP:0011723) | 1.87858011 |
| 91 | Double outlet right ventricle (HP:0001719) | 1.87858011 |
| 92 | Congenital primary aphakia (HP:0007707) | 1.87538692 |
| 93 | Colon cancer (HP:0003003) | 1.86741295 |
| 94 | Methylmalonic acidemia (HP:0002912) | 1.84853072 |
| 95 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.84725347 |
| 96 | Abnormality of renal resorption (HP:0011038) | 1.84385895 |
| 97 | Congenital hepatic fibrosis (HP:0002612) | 1.83386477 |
| 98 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.82414527 |
| 99 | Hypoplasia of the pons (HP:0012110) | 1.81875597 |
| 100 | Abnormality of the pons (HP:0007361) | 1.81376928 |
| 101 | Cerebral edema (HP:0002181) | 1.79039166 |
| 102 | Choroideremia (HP:0001139) | 1.78563053 |
| 103 | Furrowed tongue (HP:0000221) | 1.78281904 |
| 104 | Postaxial foot polydactyly (HP:0001830) | 1.78075671 |
| 105 | Severe muscular hypotonia (HP:0006829) | 1.77679784 |
| 106 | Stomach cancer (HP:0012126) | 1.77559122 |
| 107 | Tongue fasciculations (HP:0001308) | 1.74917651 |
| 108 | Constricted visual fields (HP:0001133) | 1.73585860 |
| 109 | Neurofibrillary tangles (HP:0002185) | 1.72618618 |
| 110 | Abnormality of renal excretion (HP:0011036) | 1.71566202 |
| 111 | Gonadotropin excess (HP:0000837) | 1.71343742 |
| 112 | Dandy-Walker malformation (HP:0001305) | 1.70919612 |
| 113 | Stage 5 chronic kidney disease (HP:0003774) | 1.70340696 |
| 114 | Chronic sinusitis (HP:0011109) | 1.67752566 |
| 115 | Spastic tetraparesis (HP:0001285) | 1.64556121 |
| 116 | Postaxial hand polydactyly (HP:0001162) | 1.62533778 |
| 117 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.60091486 |
| 118 | Impaired smooth pursuit (HP:0007772) | 1.59873463 |
| 119 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.59727838 |
| 120 | Muscle fibrillation (HP:0010546) | 1.59300158 |
| 121 | Nephrogenic diabetes insipidus (HP:0009806) | 1.58277728 |
| 122 | Genital tract atresia (HP:0001827) | 1.56188432 |
| 123 | Facial cleft (HP:0002006) | 1.55384594 |
| 124 | Renal dysplasia (HP:0000110) | 1.54663341 |
| 125 | Pancreatic fibrosis (HP:0100732) | 1.54555401 |
| 126 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.54085304 |
| 127 | Abnormality of the renal cortex (HP:0011035) | 1.53576927 |
| 128 | Short ribs (HP:0000773) | 1.52171361 |
| 129 | Oculomotor apraxia (HP:0000657) | 1.51090365 |
| 130 | Heterotopia (HP:0002282) | 1.50223672 |
| 131 | Vaginal atresia (HP:0000148) | 1.50148044 |
| 132 | Cerebellar dysplasia (HP:0007033) | 1.47434854 |
| 133 | Easy fatigability (HP:0003388) | 1.46110128 |
| 134 | Optic nerve hypoplasia (HP:0000609) | 1.45762425 |
| 135 | Microglossia (HP:0000171) | 1.45416566 |
| 136 | Abnormal biliary tract physiology (HP:0012439) | 1.44553384 |
| 137 | Bile duct proliferation (HP:0001408) | 1.44553384 |
| 138 | Bundle branch block (HP:0011710) | 1.44443124 |
| 139 | Abnormal urine output (HP:0012590) | 1.43785763 |
| 140 | Fatigable weakness (HP:0003473) | 1.42572688 |
| 141 | Abnormality of the neuromuscular junction (HP:0003398) | 1.42572688 |
| 142 | Cerebral inclusion bodies (HP:0100314) | 1.41084247 |
| 143 | Sensory axonal neuropathy (HP:0003390) | 1.39394238 |
| 144 | Retinal dysplasia (HP:0007973) | 1.38877955 |
| 145 | Abnormality of permanent molar morphology (HP:0011071) | 1.38380259 |
| 146 | Abnormality of the dental root (HP:0006486) | 1.38380259 |
| 147 | Taurodontia (HP:0000679) | 1.38380259 |
| 148 | Exercise-induced myalgia (HP:0003738) | 1.37826909 |
| 149 | Hemorrhage of the eye (HP:0011885) | 1.37561923 |
| 150 | Poor coordination (HP:0002370) | 1.36108618 |
| 151 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.34788863 |
| 152 | Fibular hypoplasia (HP:0003038) | 1.33123223 |
| 153 | Asymmetric septal hypertrophy (HP:0001670) | 1.30708623 |
| 154 | Cystic liver disease (HP:0006706) | 1.29538535 |
| 155 | Absent frontal sinuses (HP:0002688) | 1.29076369 |
| 156 | Abnormality of the dental pulp (HP:0006479) | 1.29025235 |
| 157 | Abnormality of molar (HP:0011077) | 1.29007272 |
| 158 | Abnormality of molar morphology (HP:0011070) | 1.29007272 |
| 159 | Type II lissencephaly (HP:0007260) | 1.27882799 |
| 160 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.27151220 |
| 161 | Abnormality of the lower motor neuron (HP:0002366) | 1.26800194 |
| 162 | Polyuria (HP:0000103) | 1.24797679 |
| 163 | Loss of speech (HP:0002371) | 1.23972048 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK3 | 7.77068636 |
| 2 | PDK4 | 7.77068636 |
| 3 | TESK1 | 6.93125961 |
| 4 | PDK2 | 4.99353578 |
| 5 | PRKD3 | 4.82319521 |
| 6 | ICK | 4.42931834 |
| 7 | MAP4K2 | 4.34726414 |
| 8 | FRK | 3.97690409 |
| 9 | ZAK | 2.83528756 |
| 10 | WNK3 | 2.64361605 |
| 11 | PTK2B | 2.61444725 |
| 12 | ADRBK2 | 2.55790428 |
| 13 | STK39 | 2.52871502 |
| 14 | WNK4 | 2.38449406 |
| 15 | STK38 | 2.30009250 |
| 16 | CASK | 2.28776887 |
| 17 | BMPR1B | 2.06969118 |
| 18 | GRK1 | 2.06464616 |
| 19 | TAOK3 | 2.03113639 |
| 20 | NUAK1 | 1.96828744 |
| 21 | MAPK13 | 1.73432313 |
| 22 | EIF2AK3 | 1.59345203 |
| 23 | TLK1 | 1.56611474 |
| 24 | PLK2 | 1.55888841 |
| 25 | TXK | 1.55519358 |
| 26 | STK16 | 1.51379940 |
| 27 | NEK2 | 1.48912751 |
| 28 | PAK3 | 1.45991511 |
| 29 | PDK1 | 1.43545473 |
| 30 | TRIM28 | 1.35840937 |
| 31 | BCKDK | 1.35427084 |
| 32 | DYRK1B | 1.33119143 |
| 33 | INSRR | 1.32127642 |
| 34 | PNCK | 1.26607782 |
| 35 | DYRK2 | 1.21014286 |
| 36 | BCR | 1.13102624 |
| 37 | ERBB3 | 1.06847315 |
| 38 | AKT3 | 1.05446402 |
| 39 | CSNK1G2 | 1.02640496 |
| 40 | PDPK1 | 1.00990246 |
| 41 | CSNK1G3 | 0.99202529 |
| 42 | NME1 | 0.98530450 |
| 43 | TYRO3 | 0.97082469 |
| 44 | PRKCE | 0.91692416 |
| 45 | CDK19 | 0.87743373 |
| 46 | LMTK2 | 0.87561523 |
| 47 | NEK1 | 0.86972048 |
| 48 | RIPK4 | 0.83986357 |
| 49 | CSNK1A1L | 0.83956324 |
| 50 | IRAK1 | 0.83323503 |
| 51 | WNK1 | 0.81963896 |
| 52 | CSNK1G1 | 0.77757896 |
| 53 | MKNK2 | 0.75467250 |
| 54 | VRK1 | 0.74485144 |
| 55 | MST4 | 0.74360739 |
| 56 | MAPKAPK3 | 0.74291323 |
| 57 | EEF2K | 0.72638109 |
| 58 | CCNB1 | 0.72569802 |
| 59 | PLK3 | 0.72524994 |
| 60 | DAPK2 | 0.72465807 |
| 61 | ADRBK1 | 0.71370889 |
| 62 | VRK2 | 0.70818902 |
| 63 | DYRK3 | 0.70046209 |
| 64 | CHEK2 | 0.65246274 |
| 65 | LIMK1 | 0.65086515 |
| 66 | MAPK15 | 0.62750390 |
| 67 | RPS6KA5 | 0.62459815 |
| 68 | PRKCI | 0.58495037 |
| 69 | STK38L | 0.58307803 |
| 70 | PHKG2 | 0.58000555 |
| 71 | PHKG1 | 0.58000555 |
| 72 | PASK | 0.57843016 |
| 73 | PINK1 | 0.57631059 |
| 74 | NTRK2 | 0.57460927 |
| 75 | TESK2 | 0.56082909 |
| 76 | TNIK | 0.54026300 |
| 77 | PRKCG | 0.52940402 |
| 78 | MAP2K7 | 0.52296061 |
| 79 | TTK | 0.50628741 |
| 80 | STK3 | 0.50418587 |
| 81 | BRSK2 | 0.49049135 |
| 82 | MUSK | 0.48606522 |
| 83 | IRAK2 | 0.48466020 |
| 84 | MAP2K6 | 0.46625801 |
| 85 | MAP3K4 | 0.46579872 |
| 86 | CSNK1A1 | 0.44306299 |
| 87 | LATS1 | 0.43123006 |
| 88 | IKBKB | 0.42424770 |
| 89 | PRKACA | 0.41953653 |
| 90 | EPHA3 | 0.39309280 |
| 91 | FER | 0.37846398 |
| 92 | TEC | 0.37570806 |
| 93 | PRKAA2 | 0.37153289 |
| 94 | MAPKAPK5 | 0.37132802 |
| 95 | BUB1 | 0.36194096 |
| 96 | CAMKK2 | 0.36192857 |
| 97 | FGFR2 | 0.36131212 |
| 98 | CAMKK1 | 0.35174870 |
| 99 | MKNK1 | 0.34870005 |
| 100 | TNK2 | 0.34620945 |
| 101 | TSSK6 | 0.34350035 |
| 102 | CAMK1 | 0.34131348 |
| 103 | PAK1 | 0.32853783 |
| 104 | BRSK1 | 0.31175808 |
| 105 | CHEK1 | 0.30934580 |
| 106 | MARK2 | 0.30923746 |
| 107 | ACVR1B | 0.30066013 |
| 108 | TGFBR1 | 0.29829439 |
| 109 | EIF2AK1 | 0.29764738 |
| 110 | PLK4 | 0.29635260 |
| 111 | GRK5 | 0.28519513 |
| 112 | NEK6 | 0.28186851 |
| 113 | WEE1 | 0.27274761 |
| 114 | GRK7 | 0.26605504 |
| 115 | PRKCZ | 0.25372782 |
| 116 | MARK1 | 0.25154659 |
| 117 | CDK15 | 0.24888679 |
| 118 | CAMK1G | 0.23931385 |
| 119 | PAK6 | 0.22067602 |
| 120 | CDK18 | 0.21956528 |
| 121 | PRKCQ | 0.21924284 |
| 122 | PKN1 | 0.21055190 |
| 123 | ATM | 0.20957468 |
| 124 | PAK2 | 0.20856949 |
| 125 | OXSR1 | 0.20789278 |
| 126 | MAP3K10 | 0.19944674 |
| 127 | PRKAA1 | 0.19877427 |
| 128 | CDK11A | 0.19603061 |
| 129 | RPS6KB1 | 0.18788367 |
| 130 | MINK1 | 0.17800391 |
| 131 | CDK14 | 0.16402390 |
| 132 | PRKG2 | 0.16312823 |
| 133 | STK11 | 0.16222950 |
| 134 | ATR | 0.14811054 |
| 135 | CAMK2A | 0.14584732 |
| 136 | MTOR | 0.13821454 |
| 137 | RIPK1 | 0.13041630 |
| 138 | PDGFRB | 0.12556086 |
| 139 | ZAP70 | 0.10895049 |
| 140 | RPS6KA1 | 0.08985973 |
| 141 | GSK3B | 0.08947719 |
| 142 | CSF1R | 0.07799536 |
| 143 | MAPK8 | 0.07696797 |
| 144 | MARK3 | 0.07583710 |
| 145 | PRKG1 | 0.07364997 |
| 146 | BRAF | 0.07277216 |
| 147 | PRKACG | 0.07029792 |
| 148 | EPHA4 | 0.07002669 |
| 149 | PLK1 | 0.05813741 |
| 150 | CDK5 | 0.05628504 |
| 151 | MAP2K4 | 0.05602024 |
| 152 | PRKCD | 0.05535815 |
| 153 | NTRK3 | 0.05478325 |
| 154 | PAK4 | 0.05282377 |
| 155 | PRKCA | 0.04678522 |
| 156 | PRKCB | 0.04423231 |
| 157 | CSNK2A1 | 0.04333063 |
| 158 | MAP3K2 | 0.01904486 |
| 159 | MAP3K1 | 0.01474939 |
| 160 | CSNK2A2 | 0.01334815 |
| 161 | STK10 | 0.01303249 |
| 162 | CDK1 | 0.00943939 |
| 163 | AURKA | 0.00443953 |
| 164 | CDK2 | 0.00366113 |
| 165 | CSNK1D | 0.00275589 |
| 166 | EGFR | 0.00239979 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 4.40883864 |
| 2 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 3.93230781 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.41177365 |
| 4 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.19806081 |
| 5 | Pyruvate metabolism_Homo sapiens_hsa00620 | 3.15930601 |
| 6 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 3.04458255 |
| 7 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.97117505 |
| 8 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.62902047 |
| 9 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.62860767 |
| 10 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 2.58336363 |
| 11 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.55442085 |
| 12 | Phototransduction_Homo sapiens_hsa04744 | 2.54978459 |
| 13 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.47378122 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.46922128 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.42445248 |
| 16 | Protein export_Homo sapiens_hsa03060 | 2.34811080 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 2.31841368 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.30200782 |
| 19 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 2.25564361 |
| 20 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.20352617 |
| 21 | Parkinsons disease_Homo sapiens_hsa05012 | 2.12510905 |
| 22 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.00385305 |
| 23 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.98223669 |
| 24 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.97549307 |
| 25 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.86447439 |
| 26 | Proteasome_Homo sapiens_hsa03050 | 1.81091307 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.80907840 |
| 28 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.76879815 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.76008289 |
| 30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.75448001 |
| 31 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.73180485 |
| 32 | RNA polymerase_Homo sapiens_hsa03020 | 1.72824877 |
| 33 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.72110993 |
| 34 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.70398149 |
| 35 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.67924684 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.67609616 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.67448536 |
| 38 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.64384603 |
| 39 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.63943004 |
| 40 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.57652892 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.54991748 |
| 42 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.53471419 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.50777792 |
| 44 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.49786661 |
| 45 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.47143656 |
| 46 | Mineral absorption_Homo sapiens_hsa04978 | 1.47098698 |
| 47 | Homologous recombination_Homo sapiens_hsa03440 | 1.47003491 |
| 48 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.43206830 |
| 49 | RNA degradation_Homo sapiens_hsa03018 | 1.42232840 |
| 50 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.39985634 |
| 51 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.38849493 |
| 52 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.34252290 |
| 53 | Renin secretion_Homo sapiens_hsa04924 | 1.33339514 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 1.31084829 |
| 55 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.29590569 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.28701619 |
| 57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.25676671 |
| 58 | Peroxisome_Homo sapiens_hsa04146 | 1.25570563 |
| 59 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.24528447 |
| 60 | Insulin secretion_Homo sapiens_hsa04911 | 1.22781241 |
| 61 | Long-term potentiation_Homo sapiens_hsa04720 | 1.20337186 |
| 62 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.18741827 |
| 63 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.18280942 |
| 64 | Morphine addiction_Homo sapiens_hsa05032 | 1.16517238 |
| 65 | Alzheimers disease_Homo sapiens_hsa05010 | 1.15610123 |
| 66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.15054473 |
| 67 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.14331297 |
| 68 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.10792354 |
| 69 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.07625503 |
| 70 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.05741771 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.05536986 |
| 72 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.05239734 |
| 73 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.03778934 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.02722396 |
| 75 | Huntingtons disease_Homo sapiens_hsa05016 | 1.00075279 |
| 76 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.97282005 |
| 77 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97164791 |
| 78 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.95912259 |
| 79 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94949537 |
| 80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.92084045 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.91787705 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.90390622 |
| 83 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.89642511 |
| 84 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.88006073 |
| 85 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.87816989 |
| 86 | Retinol metabolism_Homo sapiens_hsa00830 | 0.85907441 |
| 87 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.85650141 |
| 88 | GABAergic synapse_Homo sapiens_hsa04727 | 0.84727576 |
| 89 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.83733358 |
| 90 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83071780 |
| 91 | Salivary secretion_Homo sapiens_hsa04970 | 0.82975566 |
| 92 | Purine metabolism_Homo sapiens_hsa00230 | 0.82808855 |
| 93 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.81339323 |
| 94 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.80568292 |
| 95 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.79938934 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.78516106 |
| 97 | Bile secretion_Homo sapiens_hsa04976 | 0.77215772 |
| 98 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.76162952 |
| 99 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.75505537 |
| 100 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74423482 |
| 101 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.71726089 |
| 102 | Circadian entrainment_Homo sapiens_hsa04713 | 0.70776261 |
| 103 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.70043366 |
| 104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.67717778 |
| 105 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.67481642 |
| 106 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.67054071 |
| 107 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.66883932 |
| 108 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.66776361 |
| 109 | Cocaine addiction_Homo sapiens_hsa05030 | 0.66649058 |
| 110 | Alcoholism_Homo sapiens_hsa05034 | 0.65464576 |
| 111 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.64601719 |
| 112 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.63399136 |
| 113 | Circadian rhythm_Homo sapiens_hsa04710 | 0.63272088 |
| 114 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.60926163 |
| 115 | Taste transduction_Homo sapiens_hsa04742 | 0.60443456 |
| 116 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.59575931 |
| 117 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.59250102 |
| 118 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58855596 |
| 119 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.56039563 |
| 120 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55070602 |
| 121 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.54436040 |
| 122 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53789007 |
| 123 | Sulfur relay system_Homo sapiens_hsa04122 | 0.53458570 |
| 124 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.52826600 |
| 125 | Olfactory transduction_Homo sapiens_hsa04740 | 0.52622815 |
| 126 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.52581431 |
| 127 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.51609582 |
| 128 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.51518994 |
| 129 | Endocytosis_Homo sapiens_hsa04144 | 0.50927215 |
| 130 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.50883227 |
| 131 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.50746874 |
| 132 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.50246715 |
| 133 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.47199524 |
| 134 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.46669531 |
| 135 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.46270730 |
| 136 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.45939567 |
| 137 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45333098 |
| 138 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42400827 |
| 139 | ABC transporters_Homo sapiens_hsa02010 | 0.42163621 |
| 140 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41141006 |
| 141 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.40045893 |
| 142 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.39453650 |
| 143 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.39306788 |
| 144 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.39032307 |
| 145 | Histidine metabolism_Homo sapiens_hsa00340 | 0.38528207 |
| 146 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.38084050 |
| 147 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.37971686 |
| 148 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.37138919 |
| 149 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.36583894 |
| 150 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36219566 |
| 151 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.36154137 |
| 152 | Nicotine addiction_Homo sapiens_hsa05033 | 0.33335020 |
| 153 | Metabolic pathways_Homo sapiens_hsa01100 | 0.30898885 |
| 154 | RNA transport_Homo sapiens_hsa03013 | 0.28651468 |
| 155 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.25741719 |
| 156 | Salmonella infection_Homo sapiens_hsa05132 | 0.23551403 |
| 157 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.20118691 |
| 158 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.18014314 |
| 159 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.18013468 |
| 160 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17954421 |
| 161 | Legionellosis_Homo sapiens_hsa05134 | 0.17746304 |
| 162 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.16541218 |

