TMEM213

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1renal absorption (GO:0070293)7.83595891
2xenobiotic catabolic process (GO:0042178)7.36862621
3uronic acid metabolic process (GO:0006063)7.14700755
4glucuronate metabolic process (GO:0019585)7.14700755
5aminoglycoside antibiotic metabolic process (GO:0030647)6.85147619
6surfactant homeostasis (GO:0043129)6.84288667
7excretion (GO:0007588)6.62892549
8phosphate ion transport (GO:0006817)6.49446670
9drug transmembrane transport (GO:0006855)6.38362752
10response to nitrosative stress (GO:0051409)6.22430667
11organic cation transport (GO:0015695)6.01533671
12cellular glucuronidation (GO:0052695)6.01301364
13urate metabolic process (GO:0046415)5.87922282
14peptide catabolic process (GO:0043171)5.83303840
15phosphate ion transmembrane transport (GO:0035435)5.80796954
16one-carbon compound transport (GO:0019755)5.50902296
17drug transport (GO:0015893)5.47876572
18L-ascorbic acid metabolic process (GO:0019852)5.46912491
19glutathione derivative metabolic process (GO:1901685)5.42695493
20glutathione derivative biosynthetic process (GO:1901687)5.42695493
21chemical homeostasis within a tissue (GO:0048875)5.31957205
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.13315419
23behavioral response to nicotine (GO:0035095)5.08958387
24lysine metabolic process (GO:0006553)5.03249245
25lysine catabolic process (GO:0006554)5.03249245
26polyol transport (GO:0015791)4.84632407
27response to mercury ion (GO:0046689)4.78873055
28glutathione metabolic process (GO:0006749)4.76483277
29nonribosomal peptide biosynthetic process (GO:0019184)4.62217448
30fucose catabolic process (GO:0019317)4.53821722
31L-fucose metabolic process (GO:0042354)4.53821722
32L-fucose catabolic process (GO:0042355)4.53821722
33glyoxylate metabolic process (GO:0046487)4.29548825
34benzene-containing compound metabolic process (GO:0042537)4.29308949
35valine metabolic process (GO:0006573)4.25686614
36quaternary ammonium group transport (GO:0015697)4.11878620
37DNA deamination (GO:0045006)3.99043344
38toxin transport (GO:1901998)3.93671258
39cysteine metabolic process (GO:0006534)3.92067701
40phenylpropanoid metabolic process (GO:0009698)3.89044371
41sulfur amino acid catabolic process (GO:0000098)3.84512608
42phosphate ion homeostasis (GO:0055062)3.84506257
43trivalent inorganic anion homeostasis (GO:0072506)3.84506257
44indolalkylamine metabolic process (GO:0006586)3.83791465
45kynurenine metabolic process (GO:0070189)3.79817035
46branched-chain amino acid metabolic process (GO:0009081)3.79777913
47nephron tubule morphogenesis (GO:0072078)3.77498237
48nephron epithelium morphogenesis (GO:0072088)3.77498237
49ethanol oxidation (GO:0006069)3.77465190
50exogenous drug catabolic process (GO:0042738)3.75017335
51drug catabolic process (GO:0042737)3.73983221
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73868458
53response to pheromone (GO:0019236)3.72428034
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67611512
55modified amino acid transport (GO:0072337)3.64168535
56glutathione biosynthetic process (GO:0006750)3.64112721
57metanephric nephron tubule development (GO:0072234)3.62187650
58metanephric tubule development (GO:0072170)3.62187650
59tryptophan metabolic process (GO:0006568)3.61424404
60relaxation of cardiac muscle (GO:0055119)3.58448545
61glycoside metabolic process (GO:0016137)3.57822411
62hydrogen peroxide catabolic process (GO:0042744)3.57130492
63detection of light stimulus involved in visual perception (GO:0050908)3.54330991
64detection of light stimulus involved in sensory perception (GO:0050962)3.54330991
65regulation of skeletal muscle contraction (GO:0014819)3.49092100
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.46627209
67axoneme assembly (GO:0035082)3.43753173
68renal system process involved in regulation of blood volume (GO:0001977)3.43438479
69vitamin D metabolic process (GO:0042359)3.42202331
70platelet dense granule organization (GO:0060155)3.41978475
71sulfate transmembrane transport (GO:1902358)3.40597537
72aldehyde catabolic process (GO:0046185)3.37846907
73branched-chain amino acid catabolic process (GO:0009083)3.35769156
74tricarboxylic acid metabolic process (GO:0072350)3.35089673
75transepithelial transport (GO:0070633)3.32447456
76hormone catabolic process (GO:0042447)3.30512442
77indole-containing compound metabolic process (GO:0042430)3.27983355
78metanephric nephron epithelium development (GO:0072243)3.27331558
79short-chain fatty acid metabolic process (GO:0046459)3.26496903
80fructose metabolic process (GO:0006000)3.26201710
81cellular ketone body metabolic process (GO:0046950)3.25778314
82epithelial cilium movement (GO:0003351)3.25351500
83nephron tubule development (GO:0072080)3.21248217
84fatty acid beta-oxidation (GO:0006635)3.20408043
85bone remodeling (GO:0046849)3.20173939
86fatty acid oxidation (GO:0019395)3.18945635
87peptide biosynthetic process (GO:0043043)3.18283793
88lipid oxidation (GO:0034440)3.11428599
89positive regulation of p38MAPK cascade (GO:1900745)3.11050447
90protein-cofactor linkage (GO:0018065)3.09773915
91protein complex biogenesis (GO:0070271)3.08753143
92adaptation of signaling pathway (GO:0023058)3.08075978
93negative regulation of mast cell activation (GO:0033004)3.07684913
94homocysteine metabolic process (GO:0050667)3.06494528
95proline metabolic process (GO:0006560)3.03856920
96bicarbonate transport (GO:0015701)3.03639862
97respiratory chain complex IV assembly (GO:0008535)3.02578802
98mitochondrial respiratory chain complex I assembly (GO:0032981)3.01128395
99NADH dehydrogenase complex assembly (GO:0010257)3.01128395
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01128395
101carnitine transport (GO:0015879)3.00668225
102amino-acid betaine transport (GO:0015838)3.00668225
103negative regulation of telomere maintenance (GO:0032205)3.00625954
104gamma-aminobutyric acid transport (GO:0015812)3.00548385
105aspartate family amino acid catabolic process (GO:0009068)3.00331753
106ketone body metabolic process (GO:1902224)3.00102680
107vitamin transport (GO:0051180)3.00063464
108water-soluble vitamin biosynthetic process (GO:0042364)3.00056139
109metanephric epithelium development (GO:0072207)2.99380253
110amino-acid betaine metabolic process (GO:0006577)2.98386693
111actin filament depolymerization (GO:0030042)2.97550750
112protein localization to cilium (GO:0061512)2.97319779
113behavioral response to ethanol (GO:0048149)2.96211850
114Notch signaling involved in heart development (GO:0061314)2.95334943
115sulfur compound transport (GO:0072348)2.95114195
116cilium movement (GO:0003341)2.94809964
117vitamin transmembrane transport (GO:0035461)2.93463622
118amine catabolic process (GO:0009310)2.92661473
119cellular biogenic amine catabolic process (GO:0042402)2.92661473
120renal system process (GO:0003014)2.92486586
121nonmotile primary cilium assembly (GO:0035058)2.92114581
122piRNA metabolic process (GO:0034587)2.92013322
123carnitine metabolic process (GO:0009437)2.91300905
124regulation of cilium movement (GO:0003352)2.90887635
125retinal cone cell development (GO:0046549)2.88673792
126xenobiotic metabolic process (GO:0006805)2.88672703
127renal tubule morphogenesis (GO:0061333)2.86774440
128positive regulation of digestive system process (GO:0060456)2.86687281
129cellular modified amino acid catabolic process (GO:0042219)2.86338280
130regulation of integrin-mediated signaling pathway (GO:2001044)2.86324749
131cilium or flagellum-dependent cell motility (GO:0001539)2.86262847
132neuronal action potential (GO:0019228)2.85660407
133neural tube formation (GO:0001841)2.84065878
134protein K11-linked deubiquitination (GO:0035871)2.83985489
135mitochondrial respiratory chain complex assembly (GO:0033108)2.83979185
136response to thyroid hormone (GO:0097066)2.83671140
137nephron tubule formation (GO:0072079)2.82819063
138cilium organization (GO:0044782)2.82601524
139cornea development in camera-type eye (GO:0061303)2.82567747
140regulation of glomerular filtration (GO:0003093)2.82467597
141renal tubule development (GO:0061326)2.81712426
142indole-containing compound catabolic process (GO:0042436)2.81593227
143indolalkylamine catabolic process (GO:0046218)2.81593227
144tryptophan catabolic process (GO:0006569)2.81593227
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.81395703
146cilium morphogenesis (GO:0060271)2.79465270
147sulfation (GO:0051923)2.79038849
148renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.78575839
149sulfate transport (GO:0008272)2.78195146
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76295445
151cilium assembly (GO:0042384)2.74003928
152kidney morphogenesis (GO:0060993)2.71942104
153regulation of action potential (GO:0098900)2.71491402
154cytochrome complex assembly (GO:0017004)2.71359261
155protein polyglutamylation (GO:0018095)2.69482069
156pyrimidine nucleobase catabolic process (GO:0006208)2.69472815
157primary amino compound metabolic process (GO:1901160)2.67967145
158photoreceptor cell development (GO:0042461)2.67939834
159preassembly of GPI anchor in ER membrane (GO:0016254)2.63375910
160S-adenosylmethionine metabolic process (GO:0046500)2.62803108
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61759254
162rRNA catabolic process (GO:0016075)2.61370551
163positive regulation of fatty acid transport (GO:2000193)2.61253868
164reflex (GO:0060004)2.60293397
165photoreceptor cell maintenance (GO:0045494)2.59957836
166regulation of hexokinase activity (GO:1903299)2.59677657
167regulation of glucokinase activity (GO:0033131)2.59677657
168glycerophospholipid catabolic process (GO:0046475)2.55214389
169serotonin metabolic process (GO:0042428)2.54433441
170multicellular organism reproduction (GO:0032504)2.53718408
171amino acid salvage (GO:0043102)2.53532297
172L-methionine salvage (GO:0071267)2.53532297
173L-methionine biosynthetic process (GO:0071265)2.53532297
174dopamine transport (GO:0015872)2.53509807
175DNA methylation involved in gamete generation (GO:0043046)2.53495299
176regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51969948
177rhodopsin mediated signaling pathway (GO:0016056)2.49182199
178mannosylation (GO:0097502)2.48473408
179aromatic amino acid family catabolic process (GO:0009074)2.47554154
180reciprocal meiotic recombination (GO:0007131)2.47346401
181reciprocal DNA recombination (GO:0035825)2.47346401
182intraciliary transport (GO:0042073)2.46267742
183auditory receptor cell stereocilium organization (GO:0060088)2.46119677
184nucleobase catabolic process (GO:0046113)2.44809098
185inner ear receptor stereocilium organization (GO:0060122)2.43874312
186cAMP catabolic process (GO:0006198)2.42717283
187recombinational repair (GO:0000725)2.42472278
188fucosylation (GO:0036065)2.42112607
189transmission of nerve impulse (GO:0019226)2.42081698
190eye photoreceptor cell development (GO:0042462)2.40611038
191double-strand break repair via homologous recombination (GO:0000724)2.40593961
192synaptic transmission, cholinergic (GO:0007271)2.39804045
193axonemal dynein complex assembly (GO:0070286)2.38156713
194tachykinin receptor signaling pathway (GO:0007217)2.37859817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.40152483
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.15811333
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.98719535
4ZNF274_21170338_ChIP-Seq_K562_Hela3.83270213
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55428798
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.53208907
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34067866
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.26506780
9VDR_22108803_ChIP-Seq_LS180_Human3.22656874
10GBX2_23144817_ChIP-Seq_PC3_Human2.99810538
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.98262300
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.87839404
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.82887799
14EZH2_22144423_ChIP-Seq_EOC_Human2.65714383
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62485433
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62213058
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54172611
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.51449141
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.31727228
20IGF1R_20145208_ChIP-Seq_DFB_Human2.30132534
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28157821
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27770759
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27034552
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.22858637
25SOX2_27498859_Chip-Seq_STOMACH_Mouse2.22088135
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21644409
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20148676
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16523728
29CLOCK_20551151_ChIP-Seq_293T_Human2.11754602
30EWS_26573619_Chip-Seq_HEK293_Human2.08277725
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05464903
32P300_19829295_ChIP-Seq_ESCs_Human2.03253704
33ZNF217_24962896_ChIP-Seq_MCF-7_Human2.02135247
34TAF15_26573619_Chip-Seq_HEK293_Human1.97842396
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96530626
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.96490347
37FUS_26573619_Chip-Seq_HEK293_Human1.95519520
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.95057270
39SOX2_20726797_ChIP-Seq_SW620_Human1.91898967
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90936074
41AHR_22903824_ChIP-Seq_MCF-7_Human1.90681115
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89375384
43ER_23166858_ChIP-Seq_MCF-7_Human1.87824930
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87603678
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81141454
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79914334
47GATA4_25053715_ChIP-Seq_YYC3_Human1.74366793
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73048240
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72546248
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67110121
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63636138
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63037971
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.62584480
54IRF1_19129219_ChIP-ChIP_H3396_Human1.62182754
55BCAT_22108803_ChIP-Seq_LS180_Human1.60274121
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59794030
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59252963
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58197938
59STAT3_23295773_ChIP-Seq_U87_Human1.53249726
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52501018
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51594615
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.51408639
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50688175
64SMAD4_21799915_ChIP-Seq_A2780_Human1.50679240
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49965003
66TP53_22573176_ChIP-Seq_HFKS_Human1.49580821
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49109892
68AR_21909140_ChIP-Seq_LNCAP_Human1.48393215
69CBP_20019798_ChIP-Seq_JUKART_Human1.47821401
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47821401
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47768139
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47277380
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47277380
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.47015595
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46648640
76AR_25329375_ChIP-Seq_VCAP_Human1.44458175
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44078716
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43839263
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43839263
80TCF4_23295773_ChIP-Seq_U87_Human1.42990824
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42649260
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41339144
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39504805
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.39220630
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38881876
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38416328
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.37470694
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36362347
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36253216
90REST_21632747_ChIP-Seq_MESCs_Mouse1.35552577
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35413398
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.35413398
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34349167
94TCF4_22108803_ChIP-Seq_LS180_Human1.34098559
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33767676
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.33562517
97SOX2_19829295_ChIP-Seq_ESCs_Human1.32380727
98NANOG_19829295_ChIP-Seq_ESCs_Human1.32380727
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30969285
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.30810829
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30643096
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30643096
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.30165598
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29497014
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27806369
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27209796
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26445852
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26151171
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25496338
110* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24860090
111RUNX2_22187159_ChIP-Seq_PCA_Human1.24423677
112RACK7_27058665_Chip-Seq_MCF-7_Human1.23674664
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.23609862
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22882381
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22809349
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22776311
117GATA6_25053715_ChIP-Seq_YYC3_Human1.22681449
118MYC_18940864_ChIP-ChIP_HL60_Human1.22066618
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.20483514
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.19651915
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19307757
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19059527
123AR_21572438_ChIP-Seq_LNCaP_Human1.18917726
124TP53_18474530_ChIP-ChIP_U2OS_Human1.18819201
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.18783635
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.17837126
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17504136
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.17189223
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16836130
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.16212286
131NCOR_22424771_ChIP-Seq_293T_Human1.16211313
132RUNX1_27514584_Chip-Seq_MCF-7_Human1.15684130
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15563451
134AR_20517297_ChIP-Seq_VCAP_Human1.15561721
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15476467
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15434066
137NANOG_18555785_Chip-Seq_ESCs_Mouse1.15253751
138GATA3_24758297_ChIP-Seq_MCF-7_Human1.14780049
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14369516
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.14272843
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13836862
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12814029
143RNF2_27304074_Chip-Seq_NSC_Mouse1.12453428
144CRX_20693478_ChIP-Seq_RETINA_Mouse1.11383834
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11000974
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10867187
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10630362
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10137599
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09757943
150EST1_17652178_ChIP-ChIP_JURKAT_Human1.09005885
151P53_22387025_ChIP-Seq_ESCs_Mouse1.08830854
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07807611
153TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07518612
154TCF4_18268006_ChIP-ChIP_LS174T_Human1.07515519
155CJUN_26792858_Chip-Seq_BT549_Human1.06499469
156GATA2_21666600_ChIP-Seq_HMVEC_Human1.05997817
157HOXB7_26014856_ChIP-Seq_BT474_Human1.05743317
158SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05382313
159TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04982141
160RXR_22108803_ChIP-Seq_LS180_Human1.04443631
161STAT3_18555785_Chip-Seq_ESCs_Mouse1.03380566
162VDR_24787735_ChIP-Seq_THP-1_Human1.02550800
163KLF5_25053715_ChIP-Seq_YYC3_Human1.00786548
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00661160
165Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00601330
166CDX2_22108803_ChIP-Seq_LS180_Human0.99393339
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.99130856
168KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98839933
169E2F1_18555785_Chip-Seq_ESCs_Mouse0.97323874
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96806830
171NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96181650
172MYC_19829295_ChIP-Seq_ESCs_Human0.96025645
173POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95467929
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93753315
175OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93218808
176ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93110544
177TBX20_22080862_ChIP-Seq_HEART_Mouse0.91422041
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.91422041
179TP63_23658742_ChIP-Seq_EP156T_Human0.91160646
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88579318
181P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86373978
182SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80948565
183FOXA2_19822575_ChIP-Seq_HepG2_Human0.79701024
184NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79633935
185BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78348176
186TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76859880
187ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76744792
188FOXA1_25552417_ChIP-Seq_VCAP_Human0.76346368
189EGR1_19374776_ChIP-ChIP_THP-1_Human0.73670342
190WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72612199
191HNF4A_19822575_ChIP-Seq_HepG2_Human0.72416437
192CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72269898
193JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70820448
194* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70540332
195ZNF263_19887448_ChIP-Seq_K562_Human0.70310786
196ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.70123107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.56035091
2MP0008875_abnormal_xenobiotic_pharmacok5.17261423
3MP0004019_abnormal_vitamin_homeostasis3.90428217
4MP0005360_urolithiasis3.85678668
5MP0001958_emphysema3.72622408
6MP0009643_abnormal_urine_homeostasis3.34329148
7MP0005332_abnormal_amino_acid3.33835273
8MP0001756_abnormal_urination3.14236162
9MP0002254_reproductive_system_inflammat3.06290105
10MP0001765_abnormal_ion_homeostasis2.75255705
11MP0002136_abnormal_kidney_physiology2.68509877
12MP0003195_calcinosis2.67510534
13MP0005394_taste/olfaction_phenotype2.63172568
14MP0005499_abnormal_olfactory_system2.63172568
15MP0000569_abnormal_digit_pigmentation2.57876391
16MP0003186_abnormal_redox_activity2.54772133
17MP0002102_abnormal_ear_morphology2.52362394
18MP0008877_abnormal_DNA_methylation2.46640159
19MP0008789_abnormal_olfactory_epithelium2.44207160
20MP0005551_abnormal_eye_electrophysiolog2.39483903
21MP0002139_abnormal_hepatobiliary_system2.39287236
22MP0003878_abnormal_ear_physiology2.34902639
23MP0005377_hearing/vestibular/ear_phenot2.34902639
24MP0005636_abnormal_mineral_homeostasis2.34666416
25MP0002138_abnormal_hepatobiliary_system2.18286699
26MP0010030_abnormal_orbit_morphology2.15327549
27MP0001968_abnormal_touch/_nociception2.13547407
28MP0003941_abnormal_skin_development2.08113332
29MP0002837_dystrophic_cardiac_calcinosis2.07756507
30MP0003646_muscle_fatigue2.00511161
31MP0006292_abnormal_olfactory_placode1.94558094
32MP0003136_yellow_coat_color1.92522917
33MP0005408_hypopigmentation1.90541043
34MP0005085_abnormal_gallbladder_physiolo1.90407013
35MP0002736_abnormal_nociception_after1.89522891
36MP0008995_early_reproductive_senescence1.88452206
37MP0009046_muscle_twitch1.86029100
38MP0004133_heterotaxia1.85927208
39MP0004147_increased_porphyrin_level1.85779572
40MP0000372_irregular_coat_pigmentation1.85086736
41MP0002653_abnormal_ependyma_morphology1.82481694
42MP0006072_abnormal_retinal_apoptosis1.79989276
43MP0009745_abnormal_behavioral_response1.77222642
44MP0005646_abnormal_pituitary_gland1.75232840
45MP0005645_abnormal_hypothalamus_physiol1.74374605
46MP0004142_abnormal_muscle_tone1.74164205
47MP0005253_abnormal_eye_physiology1.71522032
48MP0003011_delayed_dark_adaptation1.71282851
49MP0003787_abnormal_imprinting1.70764416
50MP0003880_abnormal_central_pattern1.70045123
51MP0004782_abnormal_surfactant_physiolog1.69887377
52MP0000678_abnormal_parathyroid_gland1.69697939
53MP0001986_abnormal_taste_sensitivity1.67732433
54MP0002638_abnormal_pupillary_reflex1.67177224
55MP0000427_abnormal_hair_cycle1.65977918
56MP0001501_abnormal_sleep_pattern1.64733820
57MP0001984_abnormal_olfaction1.63194180
58MP0005083_abnormal_biliary_tract1.61670647
59MP0002272_abnormal_nervous_system1.57711793
60MP0004883_abnormal_blood_vessel1.54882908
61MP0001346_abnormal_lacrimal_gland1.53171202
62MP0005365_abnormal_bile_salt1.53070421
63MP0002938_white_spotting1.49744375
64MP0000631_abnormal_neuroendocrine_gland1.46453798
65MP0006276_abnormal_autonomic_nervous1.45733945
66MP0008961_abnormal_basal_metabolism1.42442628
67MP0001485_abnormal_pinna_reflex1.40677987
68MP0002168_other_aberrant_phenotype1.39491049
69MP0000534_abnormal_ureter_morphology1.39084623
70MP0003191_abnormal_cellular_cholesterol1.34946695
71MP0000538_abnormal_urinary_bladder1.34849377
72MP0001177_atelectasis1.32538125
73MP0002098_abnormal_vibrissa_morphology1.31840312
74MP0001486_abnormal_startle_reflex1.28911977
75MP0000762_abnormal_tongue_morphology1.28236356
76MP0004272_abnormal_basement_membrane1.27038814
77MP0005174_abnormal_tail_pigmentation1.26463766
78MP0002133_abnormal_respiratory_system1.23294451
79MP0005388_respiratory_system_phenotype1.23294451
80MP0005075_abnormal_melanosome_morpholog1.23004046
81MP0002572_abnormal_emotion/affect_behav1.21292928
82MP0002132_abnormal_respiratory_system1.21159218
83MP0010386_abnormal_urinary_bladder1.20619376
84MP0004885_abnormal_endolymph1.20082449
85MP0002064_seizures1.18591423
86MP0002876_abnormal_thyroid_physiology1.18571549
87MP0002135_abnormal_kidney_morphology1.18179655
88MP0004264_abnormal_extraembryonic_tissu1.15514874
89MP0001529_abnormal_vocalization1.14382121
90MP0002557_abnormal_social/conspecific_i1.13632253
91MP0003300_gastrointestinal_ulcer1.11672635
92MP0002735_abnormal_chemical_nociception1.11259659
93MP0002295_abnormal_pulmonary_circulatio1.10331501
94MP0003786_premature_aging1.09403681
95MP0001970_abnormal_pain_threshold1.09202233
96MP0001542_abnormal_bone_strength1.07462029
97MP0010368_abnormal_lymphatic_system1.07092082
98MP0002234_abnormal_pharynx_morphology1.05147589
99MP0002277_abnormal_respiratory_mucosa1.03516856
100MP0003890_abnormal_embryonic-extraembry1.02755151
101MP0003252_abnormal_bile_duct1.02624254
102MP0002733_abnormal_thermal_nociception1.02513034
103MP0002067_abnormal_sensory_capabilities1.01893125
104MP0005389_reproductive_system_phenotype1.01554950
105MP0002095_abnormal_skin_pigmentation1.01185165
106MP0002796_impaired_skin_barrier1.00357859
107MP0001905_abnormal_dopamine_level0.99696161
108MP0004924_abnormal_behavior0.99384386
109MP0005386_behavior/neurological_phenoty0.99384386
110MP0005195_abnormal_posterior_eye0.99181335
111MP0003283_abnormal_digestive_organ0.98613519
112MP0006054_spinal_hemorrhage0.95790315
113MP0001666_abnormal_nutrient_absorption0.94415779
114MP0002063_abnormal_learning/memory/cond0.93964485
115MP0003635_abnormal_synaptic_transmissio0.92743253
116MP0009053_abnormal_anal_canal0.92579539
117MP0005395_other_phenotype0.91743447
118MP0003718_maternal_effect0.91399124
119MP0005164_abnormal_response_to0.91374606
120MP0000681_abnormal_thyroid_gland0.89147551
121MP0000026_abnormal_inner_ear0.88762690
122MP0009764_decreased_sensitivity_to0.88732413
123MP0004145_abnormal_muscle_electrophysio0.88567965
124MP0001324_abnormal_eye_pigmentation0.88353824
125MP0002160_abnormal_reproductive_system0.88326121
126MP0000613_abnormal_salivary_gland0.88106600
127MP0005058_abnormal_lysosome_morphology0.87323756
128MP0003566_abnormal_cell_adhesion0.86375271
129MP0001919_abnormal_reproductive_system0.85557394
130MP0000778_abnormal_nervous_system0.84834167
131MP0009379_abnormal_foot_pigmentation0.84689301
132MP0002752_abnormal_somatic_nervous0.80938682
133MP0005410_abnormal_fertilization0.80783490
134MP0005379_endocrine/exocrine_gland_phen0.80709550
135MP0001270_distended_abdomen0.80390533
136MP0002928_abnormal_bile_duct0.79699599
137MP0000647_abnormal_sebaceous_gland0.78158247
138MP0003698_abnormal_male_reproductive0.77524024
139MP0000566_synostosis0.77504396
140MP0002734_abnormal_mechanical_nocicepti0.77136156
141MP0002751_abnormal_autonomic_nervous0.76343267
142MP0002229_neurodegeneration0.75639522
143MP0005584_abnormal_enzyme/coenzyme_acti0.75173242
144MP0003121_genomic_imprinting0.75040342
145MP0002233_abnormal_nose_morphology0.74447256
146MP0009780_abnormal_chondrocyte_physiolo0.74278340
147MP0001963_abnormal_hearing_physiology0.74046244
148MP0005084_abnormal_gallbladder_morpholo0.73161907
149MP0000537_abnormal_urethra_morphology0.72673796
150MP0003115_abnormal_respiratory_system0.72648248
151MP0000230_abnormal_systemic_arterial0.71952625
152MP0003942_abnormal_urinary_system0.71521921
153MP0005595_abnormal_vascular_smooth0.68533514
154MP0010329_abnormal_lipoprotein_level0.64444178
155MP0005319_abnormal_enzyme/_coenzyme0.62925606
156MP0002896_abnormal_bone_mineralization0.59628732
157MP0000383_abnormal_hair_follicle0.57208214
158MP0003828_pulmonary_edema0.57102564
159MP0010234_abnormal_vibrissa_follicle0.56193035
160MP0008872_abnormal_physiological_respon0.55586720
161MP0003329_amyloid_beta_deposits0.54886512
162MP0002998_abnormal_bone_remodeling0.53775874
163MP0002089_abnormal_postnatal_growth/wei0.53450565
164MP0003638_abnormal_response/metabolism_0.51545296
165MP0001849_ear_inflammation0.51273610
166MP0010678_abnormal_skin_adnexa0.51207134
167MP0009250_abnormal_appendicular_skeleto0.50807662
168MP0009384_cardiac_valve_regurgitation0.49692018
169MP0004484_altered_response_of0.49271921
170MP0000163_abnormal_cartilage_morphology0.48753552
171MP0000462_abnormal_digestive_system0.48465282
172MP0004742_abnormal_vestibular_system0.47160247
173MP0002118_abnormal_lipid_homeostasis0.47092501
174MP0001879_abnormal_lymphatic_vessel0.45323800

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.95273628
2Hypokalemic alkalosis (HP:0001949)7.72468261
3Increased circulating renin level (HP:0000848)7.48712018
4Metabolic alkalosis (HP:0200114)7.44192867
5Abnormality of chloride homeostasis (HP:0011422)7.11719852
6Gout (HP:0001997)6.73972836
7Hypomagnesemia (HP:0002917)6.64984599
8Renal salt wasting (HP:0000127)6.20444395
9Polyuria (HP:0000103)5.91567903
10Abnormality of magnesium homeostasis (HP:0004921)5.72123523
11Abnormality of renal excretion (HP:0011036)5.64455900
12Abnormal urine output (HP:0012590)5.47531426
13Tetany (HP:0001281)5.43197562
14Hyperaldosteronism (HP:0000859)5.30734438
15Abnormality of renin-angiotensin system (HP:0000847)5.12357220
16Polydipsia (HP:0001959)4.99625577
17Abnormal drinking behavior (HP:0030082)4.99625577
18Alkalosis (HP:0001948)4.71728045
19Pancreatic cysts (HP:0001737)4.69952816
20Increased purine levels (HP:0004368)4.56539554
21Hyperuricemia (HP:0002149)4.56539554
22Renal tubular acidosis (HP:0001947)4.41845739
23Proximal tubulopathy (HP:0000114)4.19798151
24Abnormality of midbrain morphology (HP:0002418)4.08895629
25Molar tooth sign on MRI (HP:0002419)4.08895629
26Pancreatic fibrosis (HP:0100732)4.07955896
27Congenital stationary night blindness (HP:0007642)3.98735710
28True hermaphroditism (HP:0010459)3.95327856
29Hypokalemia (HP:0002900)3.73786411
30Hypercalciuria (HP:0002150)3.71910679
31Abnormality of purine metabolism (HP:0004352)3.66731530
32Nephronophthisis (HP:0000090)3.66263870
33Hyperglycinuria (HP:0003108)3.64975424
34Abnormality of the renal medulla (HP:0100957)3.51709501
35Tubulointerstitial fibrosis (HP:0005576)3.37977572
36Generalized aminoaciduria (HP:0002909)3.34686886
37Abnormality of potassium homeostasis (HP:0011042)3.27262059
38Glycosuria (HP:0003076)3.24027016
39Abnormality of urine glucose concentration (HP:0011016)3.24027016
40Hyperventilation (HP:0002883)3.13370578
41Cystic liver disease (HP:0006706)2.97475134
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.97015107
43Type II lissencephaly (HP:0007260)2.95652320
44Renal tubular dysfunction (HP:0000124)2.90168117
45Medial flaring of the eyebrow (HP:0010747)2.89787501
46Chronic hepatic failure (HP:0100626)2.83459455
47Abnormality of fatty-acid metabolism (HP:0004359)2.80450075
48Abnormality of serine family amino acid metabolism (HP:0010894)2.76042677
49Abnormality of glycine metabolism (HP:0010895)2.76042677
50Abolished electroretinogram (ERG) (HP:0000550)2.70652723
51Pendular nystagmus (HP:0012043)2.64864474
52Attenuation of retinal blood vessels (HP:0007843)2.64540881
53Bilateral sensorineural hearing impairment (HP:0008619)2.62909724
54Dehydration (HP:0001944)2.62735452
55Hyperphosphaturia (HP:0003109)2.62703551
56Abnormality of nucleobase metabolism (HP:0010932)2.59624853
57Nephrocalcinosis (HP:0000121)2.58097527
58Abnormality of sodium homeostasis (HP:0010931)2.54034192
59Abnormal rod and cone electroretinograms (HP:0008323)2.53573872
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53317289
61Abnormality of alanine metabolism (HP:0010916)2.53317289
62Hyperalaninemia (HP:0003348)2.53317289
63Thin bony cortex (HP:0002753)2.53264095
64Renal cortical cysts (HP:0000803)2.49408290
65Decreased circulating renin level (HP:0003351)2.47637360
66Inability to walk (HP:0002540)2.44029972
67Abnormal urine phosphate concentration (HP:0012599)2.43231492
68Tubular atrophy (HP:0000092)2.43155247
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.42348917
70Absent/shortened dynein arms (HP:0200106)2.42348917
71Hyponatremia (HP:0002902)2.40985013
72Nephrogenic diabetes insipidus (HP:0009806)2.38003877
73Ketoacidosis (HP:0001993)2.37810095
74Potter facies (HP:0002009)2.36116277
75Facial shape deformation (HP:0011334)2.36116277
76Chondrocalcinosis (HP:0000934)2.35250289
77Adrenal overactivity (HP:0002717)2.32462305
78Vacuolated lymphocytes (HP:0001922)2.29808410
79Gait imbalance (HP:0002141)2.28765585
80Progressive inability to walk (HP:0002505)2.27737062
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27102540
82Abnormality of Sharpey fibers (HP:0100685)2.26996534
83Abnormal respiratory motile cilium morphology (HP:0005938)2.26046935
84Abnormal respiratory epithelium morphology (HP:0012253)2.26046935
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.25511069
86Sclerocornea (HP:0000647)2.24953953
87Abnormal tarsal ossification (HP:0008369)2.22677377
88Persistence of primary teeth (HP:0006335)2.22275688
89Congenital primary aphakia (HP:0007707)2.21581009
90Hyperkalemia (HP:0002153)2.18975920
91Congenital hepatic fibrosis (HP:0002612)2.18713312
92Tubulointerstitial abnormality (HP:0001969)2.17668550
93Anencephaly (HP:0002323)2.17502977
94Furrowed tongue (HP:0000221)2.16997265
95Keratoconus (HP:0000563)2.16929356
96Increased corneal curvature (HP:0100692)2.16929356
97Broad-based gait (HP:0002136)2.16512472
98Onycholysis (HP:0001806)2.16403426
99Hypothermia (HP:0002045)2.15199968
100Hypotension (HP:0002615)2.13829212
101Gaze-evoked nystagmus (HP:0000640)2.12964450
102Abnormal ciliary motility (HP:0012262)2.12690421
103Delayed epiphyseal ossification (HP:0002663)2.10310984
104Glomerulosclerosis (HP:0000096)2.09859623
105Decreased central vision (HP:0007663)2.09316881
106Abnormality of proline metabolism (HP:0010907)2.09298517
107Hydroxyprolinuria (HP:0003080)2.09298517
108Aplasia/Hypoplasia of the tibia (HP:0005772)2.03762664
109Malnutrition (HP:0004395)2.03119839
110Congenital, generalized hypertrichosis (HP:0004540)2.00569726
111Cerebellar dysplasia (HP:0007033)1.99100611
112Postaxial foot polydactyly (HP:0001830)1.98935722
113Lissencephaly (HP:0001339)1.97379233
114Male pseudohermaphroditism (HP:0000037)1.97362218
115Rickets (HP:0002748)1.96940159
116Genital tract atresia (HP:0001827)1.96874587
117Large for gestational age (HP:0001520)1.95491509
118Bile duct proliferation (HP:0001408)1.95064901
119Abnormal biliary tract physiology (HP:0012439)1.95064901
120Nephrolithiasis (HP:0000787)1.94799125
121Abnormality of the renal cortex (HP:0011035)1.93956560
122Increased CSF lactate (HP:0002490)1.91997236
123Mitochondrial inheritance (HP:0001427)1.91236550
124Progressive cerebellar ataxia (HP:0002073)1.89677015
125Vaginal atresia (HP:0000148)1.89541722
126Delayed CNS myelination (HP:0002188)1.88911678
127Metaphyseal cupping (HP:0003021)1.88894007
128Bony spicule pigmentary retinopathy (HP:0007737)1.88377383
129Acute necrotizing encephalopathy (HP:0006965)1.88172175
130Abnormality of the pons (HP:0007361)1.86204655
131Widely patent fontanelles and sutures (HP:0004492)1.86112902
132Hypoplasia of the pons (HP:0012110)1.84327884
133Aplasia/hypoplasia of the uterus (HP:0008684)1.84177374
134Chorioretinal atrophy (HP:0000533)1.83898183
135Patellar aplasia (HP:0006443)1.82645187
136Protruding tongue (HP:0010808)1.82170282
137Focal motor seizures (HP:0011153)1.82045929
138Abnormality of the labia minora (HP:0012880)1.81886962
139Ketosis (HP:0001946)1.81633209
140Abnormal respiratory motile cilium physiology (HP:0012261)1.81329216
141Osteomalacia (HP:0002749)1.81070023
142Abnormality of the middle phalanges of the toes (HP:0010183)1.80715412
143Vascular calcification (HP:0004934)1.79761945
144Stomach cancer (HP:0012126)1.79600986
145Vomiting (HP:0002013)1.79512779
146Tubulointerstitial nephritis (HP:0001970)1.79179495
147Abnormality of carpal bone ossification (HP:0006257)1.77979439
148Aplasia/Hypoplasia of the patella (HP:0006498)1.77680122
149Fair hair (HP:0002286)1.77312501
1503-Methylglutaconic aciduria (HP:0003535)1.75576113
151Abnormality of renal resorption (HP:0011038)1.75104235
152Bicornuate uterus (HP:0000813)1.75035008
153Postaxial hand polydactyly (HP:0001162)1.74611030
154Optic nerve hypoplasia (HP:0000609)1.74384469
155Febrile seizures (HP:0002373)1.73916993
156Stenosis of the external auditory canal (HP:0000402)1.72134874
157Abnormal hemoglobin (HP:0011902)1.71914208
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71008218
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70336244
160Metabolic acidosis (HP:0001942)1.69761252
161Enlarged kidneys (HP:0000105)1.69561477
162Large eyes (HP:0001090)1.68694025
163Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66015711
164Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64596995
165Choanal stenosis (HP:0000452)1.63286341
166Abnormal pancreas size (HP:0012094)1.62612231
167Lip pit (HP:0100267)1.61558253
168Hyperglycinemia (HP:0002154)1.61435940
169Split foot (HP:0001839)1.60342639
170Tachypnea (HP:0002789)1.58828760
171Alveolar cell carcinoma (HP:0006519)1.58332648
172Hypophosphatemia (HP:0002148)1.57944817
173Generalized muscle weakness (HP:0003324)1.56781096
174Cardiovascular calcification (HP:0011915)1.56139755
175Nausea (HP:0002018)1.53950086
176Dicarboxylic aciduria (HP:0003215)1.53062710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.27953299
2OXSR15.08671184
3WNK34.71774097
4STK393.91579354
5MST43.12552720
6MAP3K33.09327463
7MAP4K22.68016830
8SGK22.50842136
9SGK2232.49060259
10SGK4942.49060259
11GRK12.42747813
12TAOK32.34121221
13ACVR1B2.23061205
14INSRR2.15062874
15TAOK12.13173988
16TLK12.11581259
17TAOK22.07411267
18TESK12.07219851
19STK38L2.03287292
20DAPK22.02979322
21SGK32.02727118
22MAP3K111.89913052
23MAPK131.88721951
24TGFBR21.78877859
25CASK1.76781174
26EPHB11.74129557
27TXK1.65873672
28WNK11.59738571
29PDK21.55172865
30BCKDK1.55166886
31MAP2K31.53769546
32STK101.49322046
33EPHA21.45003689
34MAP3K41.42348610
35ERBB31.35208025
36PDK41.34346675
37PDK31.34346675
38EPHB21.24739736
39MST1R1.22935217
40TNIK1.22302362
41MARK11.18179307
42RPS6KB21.13312780
43ADRBK11.10967430
44EPHA31.08820661
45PAK41.07417949
46DYRK21.06805229
47LIMK11.04295229
48FER1.03031130
49BMPR21.02308856
50NTRK31.01715678
51NME11.00262008
52MKNK20.99898436
53ZAK0.95558482
54LRRK20.94868817
55GRK70.93268847
56MUSK0.91449807
57PRKCG0.89148647
58NUAK10.88920718
59LMTK20.88870562
60VRK10.84791672
61PNCK0.84535734
62PTK20.83420762
63MAPKAPK30.82790447
64MAPK150.81280902
65PLK20.80941943
66PHKG20.80012598
67PHKG10.80012598
68TRIM280.79311900
69STK380.77344700
70MAP2K70.76938626
71MYLK0.76696324
72CSNK1G20.76585361
73PIK3CA0.74693687
74PTK2B0.73020362
75MAP3K20.72987154
76CSNK1G10.72851443
77ERN10.68610176
78BCR0.68356297
79MAP2K20.67460889
80CAMKK20.66667557
81PRKCI0.66179752
82GSK3A0.66090250
83BRSK20.65806619
84FGFR40.64044550
85PBK0.63939014
86FRK0.63567062
87CSNK1G30.62864282
88CSNK1A1L0.60355748
89PRKCQ0.55976699
90IKBKB0.55869115
91EPHA40.53425361
92KIT0.53157223
93TGFBR10.51569002
94VRK20.51344382
95SGK10.51209040
96PLK30.49639043
97STK30.48707811
98CAMK2A0.48409611
99PRKCE0.47163292
100PRKACA0.46256363
101WEE10.45891759
102NTRK20.45011504
103TEC0.44628705
104PKN10.44358350
105RPS6KA50.43782452
106CDK190.43405371
107HIPK20.43249292
108CSNK1A10.42653171
109MAP3K10.42594137
110MAP2K10.42521299
111MAPKAPK50.42096803
112SIK30.41728951
113PINK10.40386499
114NEK60.40246982
115STK110.39817957
116FLT30.39239370
117PAK30.39051910
118IRAK10.37472857
119TNK20.37029266
120STK160.36961839
121MAP3K120.36955796
122MKNK10.36116488
123PRKAA10.34744686
124ITK0.33474876
125CSNK1D0.32742895
126PRKCA0.32721035
127CAMK10.32418042
128PLK40.32337577
129PRKCD0.32279143
130PRKAA20.32249327
131NLK0.31105758
132FGFR20.31082507
133ZAP700.29132825
134PTK60.28734863
135NEK20.28699405
136ROCK10.25468322
137GRK50.24934965
138ADRBK20.24234706
139PDGFRB0.23587841
140TRIB30.22799861
141MET0.21737690
142BTK0.20509057
143CDK60.20164388
144NEK10.20038551
145MAP3K140.19090580
146MAP3K70.18870499
147PRKCZ0.18715851
148ERBB20.18668199
149BMPR1B0.18240536
150SIK10.17954545
151LATS10.17122389
152CHUK0.16739506
153MOS0.16329597
154NEK90.16257431
155ROCK20.15620714
156ABL20.14061400
157IGF1R0.13775791
158ILK0.13495830
159LATS20.13364055
160MAPKAPK20.12793084
161IRAK30.12642559
162MAP2K60.12550073
163TIE10.12085446

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000404.86495926
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.55814555
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.75483395
4Sulfur metabolism_Homo sapiens_hsa009203.49277985
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.46562975
6Chemical carcinogenesis_Homo sapiens_hsa052043.02592435
7Butanoate metabolism_Homo sapiens_hsa006502.98334390
8Phototransduction_Homo sapiens_hsa047442.82153914
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76940024
10Glutathione metabolism_Homo sapiens_hsa004802.72635823
11Linoleic acid metabolism_Homo sapiens_hsa005912.54925091
12Collecting duct acid secretion_Homo sapiens_hsa049662.46823219
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44824959
14Nitrogen metabolism_Homo sapiens_hsa009102.40956160
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.24528518
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19642992
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18150063
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17212058
19Nicotine addiction_Homo sapiens_hsa050332.14323999
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14163493
21Propanoate metabolism_Homo sapiens_hsa006402.06644484
22Maturity onset diabetes of the young_Homo sapiens_hsa049502.03679503
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94343389
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.94334747
25Starch and sucrose metabolism_Homo sapiens_hsa005001.87662143
26Peroxisome_Homo sapiens_hsa041461.87075455
27beta-Alanine metabolism_Homo sapiens_hsa004101.83598314
28Homologous recombination_Homo sapiens_hsa034401.81000038
29Ether lipid metabolism_Homo sapiens_hsa005651.76345434
30Fatty acid degradation_Homo sapiens_hsa000711.75866743
31Protein export_Homo sapiens_hsa030601.75472215
32Mineral absorption_Homo sapiens_hsa049781.71877216
33Sulfur relay system_Homo sapiens_hsa041221.69402312
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68672990
35Retinol metabolism_Homo sapiens_hsa008301.68508171
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66074697
37Basal transcription factors_Homo sapiens_hsa030221.54632398
38Fanconi anemia pathway_Homo sapiens_hsa034601.53353520
39Taste transduction_Homo sapiens_hsa047421.52684123
40RNA polymerase_Homo sapiens_hsa030201.47696486
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42793695
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.40400175
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39284879
44Vitamin digestion and absorption_Homo sapiens_hsa049771.36924530
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.32101739
46Histidine metabolism_Homo sapiens_hsa003401.29028098
47Morphine addiction_Homo sapiens_hsa050321.25562941
48Olfactory transduction_Homo sapiens_hsa047401.25439393
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25338722
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22262251
51Tryptophan metabolism_Homo sapiens_hsa003801.19070910
52Pyruvate metabolism_Homo sapiens_hsa006201.12658384
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09831231
54RNA degradation_Homo sapiens_hsa030181.09408065
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05690289
56Bile secretion_Homo sapiens_hsa049761.04469379
57Cardiac muscle contraction_Homo sapiens_hsa042601.02464359
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02291024
59One carbon pool by folate_Homo sapiens_hsa006700.99523362
60Other glycan degradation_Homo sapiens_hsa005110.99206908
61Arginine and proline metabolism_Homo sapiens_hsa003300.98470697
62GABAergic synapse_Homo sapiens_hsa047270.95176996
63Fatty acid metabolism_Homo sapiens_hsa012120.93308158
64Regulation of autophagy_Homo sapiens_hsa041400.93305232
65Protein digestion and absorption_Homo sapiens_hsa049740.90577613
66Phenylalanine metabolism_Homo sapiens_hsa003600.90494238
67Insulin secretion_Homo sapiens_hsa049110.89793818
68Serotonergic synapse_Homo sapiens_hsa047260.88378636
69Glutamatergic synapse_Homo sapiens_hsa047240.87942478
70Primary immunodeficiency_Homo sapiens_hsa053400.86312663
71Oxidative phosphorylation_Homo sapiens_hsa001900.85549409
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84176645
73Vibrio cholerae infection_Homo sapiens_hsa051100.82431348
74Circadian entrainment_Homo sapiens_hsa047130.81649263
75Carbon metabolism_Homo sapiens_hsa012000.80268215
76Gastric acid secretion_Homo sapiens_hsa049710.77658214
77Ovarian steroidogenesis_Homo sapiens_hsa049130.77421980
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75962419
79Asthma_Homo sapiens_hsa053100.75850108
80Tight junction_Homo sapiens_hsa045300.73004078
81Tyrosine metabolism_Homo sapiens_hsa003500.72185129
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72074396
83Galactose metabolism_Homo sapiens_hsa000520.71478141
84Selenocompound metabolism_Homo sapiens_hsa004500.71427711
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.68395341
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66734415
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66707834
88Rheumatoid arthritis_Homo sapiens_hsa053230.65585685
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65261532
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64988952
91Proteasome_Homo sapiens_hsa030500.64923305
92Salivary secretion_Homo sapiens_hsa049700.64748374
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64428160
94Calcium signaling pathway_Homo sapiens_hsa040200.62327598
95PPAR signaling pathway_Homo sapiens_hsa033200.62308980
96Lysosome_Homo sapiens_hsa041420.60015647
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.59213317
98Fructose and mannose metabolism_Homo sapiens_hsa000510.59194209
99Purine metabolism_Homo sapiens_hsa002300.58453784
100Fat digestion and absorption_Homo sapiens_hsa049750.57976258
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57036275
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57014925
103Arachidonic acid metabolism_Homo sapiens_hsa005900.56820719
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.54447102
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52988643
106Thyroid hormone synthesis_Homo sapiens_hsa049180.52881512
107ECM-receptor interaction_Homo sapiens_hsa045120.52833512
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51390505
109Type I diabetes mellitus_Homo sapiens_hsa049400.50425027
110Adherens junction_Homo sapiens_hsa045200.49306214
111Glycerolipid metabolism_Homo sapiens_hsa005610.47905287
112Renin-angiotensin system_Homo sapiens_hsa046140.44841470
113Dorso-ventral axis formation_Homo sapiens_hsa043200.43534124
114Lysine degradation_Homo sapiens_hsa003100.42648698
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41138314
116Metabolic pathways_Homo sapiens_hsa011000.39479686
117Bladder cancer_Homo sapiens_hsa052190.39362752
118Folate biosynthesis_Homo sapiens_hsa007900.37504743
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37461813
120Pentose phosphate pathway_Homo sapiens_hsa000300.37223338
121Pyrimidine metabolism_Homo sapiens_hsa002400.36723925
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34922148
123Hepatitis C_Homo sapiens_hsa051600.34788986
124Dopaminergic synapse_Homo sapiens_hsa047280.34705302
125Non-homologous end-joining_Homo sapiens_hsa034500.33987250
126Hippo signaling pathway_Homo sapiens_hsa043900.31894424
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.31463609
128Autoimmune thyroid disease_Homo sapiens_hsa053200.30632841
129Nucleotide excision repair_Homo sapiens_hsa034200.30541519
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29397976
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27474494
132Circadian rhythm_Homo sapiens_hsa047100.25678357
133Phagosome_Homo sapiens_hsa041450.25438506
134Parkinsons disease_Homo sapiens_hsa050120.25116479
135ABC transporters_Homo sapiens_hsa020100.24975345
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24597366
137Fatty acid elongation_Homo sapiens_hsa000620.24349780
138Arginine biosynthesis_Homo sapiens_hsa002200.24028105
139Synaptic vesicle cycle_Homo sapiens_hsa047210.23946684
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20212882
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18093044
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14030939
143Alzheimers disease_Homo sapiens_hsa050100.12911103
144Steroid biosynthesis_Homo sapiens_hsa001000.12579229
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12297780
146Amoebiasis_Homo sapiens_hsa051460.11622946
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11161263
148FoxO signaling pathway_Homo sapiens_hsa040680.10217900
149Biosynthesis of amino acids_Homo sapiens_hsa012300.09050520
150Huntingtons disease_Homo sapiens_hsa050160.07733600
151Caffeine metabolism_Homo sapiens_hsa002320.06035043

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