ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	7.53473750
2	Golgi transport vesicle coating (GO:0048200)	7.53473750
3	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	6.63530265
4	protein retention in ER lumen (GO:0006621)	6.28372905
5	COPII vesicle coating (GO:0048208)	5.19757562
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.00971652
7	L-phenylalanine catabolic process (GO:0006559)	5.00971652
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.00376340
9	L-phenylalanine metabolic process (GO:0006558)	5.00376340
10	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	4.88188715
11	exocrine pancreas development (GO:0031017)	4.85875591
12	4-hydroxyproline metabolic process (GO:0019471)	4.81017424
13	intestinal cholesterol absorption (GO:0030299)	4.66990009
14	positive regulation of nuclease activity (GO:0032075)	4.63574213
15	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	4.58643406
16	sulfur amino acid catabolic process (GO:0000098)	4.40322315
17	proline biosynthetic process (GO:0006561)	4.40265705
18	skin morphogenesis (GO:0043589)	4.28814962
19	cysteine metabolic process (GO:0006534)	4.25963769
20	endoplasmic reticulum unfolded protein response (GO:0030968)	4.23745825
21	protein carboxylation (GO:0018214)	4.16256005
22	peptidyl-glutamic acid carboxylation (GO:0017187)	4.16256005
23	regulation of nuclease activity (GO:0032069)	4.15487298
24	cellular response to unfolded protein (GO:0034620)	4.12566151
25	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.03128305
26	basement membrane organization (GO:0071711)	3.99116458
27	ER-nucleus signaling pathway (GO:0006984)	3.97103389
28	valine metabolic process (GO:0006573)	3.93714402
29	aromatic amino acid family catabolic process (GO:0009074)	3.91804245
30	negative regulation of fibrinolysis (GO:0051918)	3.87377341
31	cellular response to topologically incorrect protein (GO:0035967)	3.86124997
32	alpha-linolenic acid metabolic process (GO:0036109)	3.82535567
33	homocysteine metabolic process (GO:0050667)	3.79112456
34	glyoxylate metabolic process (GO:0046487)	3.76920471
35	regulation of cholesterol homeostasis (GO:2000188)	3.72258915
36	lysine catabolic process (GO:0006554)	3.71175615
37	lysine metabolic process (GO:0006553)	3.71175615
38	cellular modified amino acid catabolic process (GO:0042219)	3.70092525
39	high-density lipoprotein particle remodeling (GO:0034375)	3.64865957
40	vesicle coating (GO:0006901)	3.64133754
41	regulation of early endosome to late endosome transport (GO:2000641)	3.60164634
42	proline metabolic process (GO:0006560)	3.55642076
43	urea cycle (GO:0000050)	3.55633620
44	urea metabolic process (GO:0019627)	3.55633620
45	response to endoplasmic reticulum stress (GO:0034976)	3.51166049
46	mannose metabolic process (GO:0006013)	3.50301181
47	regulation of fibrinolysis (GO:0051917)	3.48863939
48	reverse cholesterol transport (GO:0043691)	3.46721234
49	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	3.41314568
50	regulation of extracellular matrix disassembly (GO:0010715)	3.40924109
51	pinocytosis (GO:0006907)	3.39153705
52	regulation of protein activation cascade (GO:2000257)	3.38772041
53	cell-substrate junction assembly (GO:0007044)	3.38083169
54	peptidyl-proline hydroxylation (GO:0019511)	3.37375741
55	positive regulation of extracellular matrix organization (GO:1903055)	3.35414096
56	response to unfolded protein (GO:0006986)	3.35298248
57	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.29681079
58	L-alpha-amino acid transmembrane transport (GO:1902475)	3.25635300
59	complement activation, alternative pathway (GO:0006957)	3.24089391
60	nitrogen cycle metabolic process (GO:0071941)	3.23425323
61	response to topologically incorrect protein (GO:0035966)	3.21518663
62	serine family amino acid catabolic process (GO:0009071)	3.21452230
63	endodermal cell differentiation (GO:0035987)	3.19657381
64	regulation of complement activation (GO:0030449)	3.19315805
65	kynurenine metabolic process (GO:0070189)	3.19292307
66	triglyceride homeostasis (GO:0070328)	3.16991023
67	acylglycerol homeostasis (GO:0055090)	3.16991023
68	glycine metabolic process (GO:0006544)	3.16572951
69	plasma lipoprotein particle clearance (GO:0034381)	3.15456948
70	hemidesmosome assembly (GO:0031581)	3.15100423
71	focal adhesion assembly (GO:0048041)	3.14879386
72	cell-substrate adherens junction assembly (GO:0007045)	3.14879386
73	protein localization to endosome (GO:0036010)	3.14630791
74	desmosome organization (GO:0002934)	3.13858095
75	bile acid biosynthetic process (GO:0006699)	3.13536957
76	intestinal absorption (GO:0050892)	3.12103846
77	regulation of fatty acid beta-oxidation (GO:0031998)	3.10867061
78	stress fiber assembly (GO:0043149)	3.09420382
79	adhesion of symbiont to host (GO:0044406)	3.09275811
80	barbed-end actin filament capping (GO:0051016)	3.08257456
81	tryptophan metabolic process (GO:0006568)	3.07946273
82	indole-containing compound catabolic process (GO:0042436)	3.07271759
83	indolalkylamine catabolic process (GO:0046218)	3.07271759
84	tryptophan catabolic process (GO:0006569)	3.07271759
85	adherens junction assembly (GO:0034333)	3.06928400
86	2-oxoglutarate metabolic process (GO:0006103)	3.06840946
87	plasma lipoprotein particle remodeling (GO:0034369)	3.05267987
88	protein-lipid complex remodeling (GO:0034368)	3.05267987
89	macromolecular complex remodeling (GO:0034367)	3.05267987
90	amino-acid betaine metabolic process (GO:0006577)	3.03130971
91	serine family amino acid metabolic process (GO:0009069)	3.02200389
92	regulation of plasminogen activation (GO:0010755)	3.00946593
93	protein maturation by protein folding (GO:0022417)	3.00870581
94	cell adhesion mediated by integrin (GO:0033627)	3.00373044
95	hyaluronan catabolic process (GO:0030214)	2.99931157
96	serine family amino acid biosynthetic process (GO:0009070)	2.98265803
97	peptidyl-asparagine modification (GO:0018196)	2.97166877
98	glutamine family amino acid biosynthetic process (GO:0009084)	2.97075522
99	protein N-linked glycosylation via asparagine (GO:0018279)	2.96529617
100	positive regulation of glycolytic process (GO:0045821)	2.96385671
101	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.95679924
102	protein hydroxylation (GO:0018126)	2.94360885
103	aspartate family amino acid catabolic process (GO:0009068)	2.93834176
104	tricarboxylic acid metabolic process (GO:0072350)	2.93449640
105	lipoprotein metabolic process (GO:0042157)	2.93193894
106	alpha-amino acid catabolic process (GO:1901606)	2.92964330
107	endocrine pancreas development (GO:0031018)	2.92598345
108	cellular amino acid catabolic process (GO:0009063)	2.91889205
109	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.91271693
110	protein autoprocessing (GO:0016540)	2.90327021
111	negative regulation of cholesterol transport (GO:0032375)	2.89981949
112	negative regulation of sterol transport (GO:0032372)	2.89981949
113	apoptotic cell clearance (GO:0043277)	2.89651285
114	aromatic amino acid family metabolic process (GO:0009072)	2.89454465
115	regulation of triglyceride catabolic process (GO:0010896)	2.87634148
116	transcytosis (GO:0045056)	2.87295022
117	bile acid metabolic process (GO:0008206)	2.87137148
118	one-carbon metabolic process (GO:0006730)	2.86898617
119	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.86559024
120	tyrosine metabolic process (GO:0006570)	2.84964187
121	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.83860966
122	GDP-mannose metabolic process (GO:0019673)	2.83231119
123	collagen fibril organization (GO:0030199)	2.82999457
124	positive regulation of triglyceride metabolic process (GO:0090208)	2.82621257
125	epithelial cell-cell adhesion (GO:0090136)	2.81828948
126	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.80591768
127	low-density lipoprotein particle clearance (GO:0034383)	2.80109812
128	cholesterol catabolic process (GO:0006707)	2.79811944
129	negative regulation of fatty acid transport (GO:2000192)	2.74759833
130	glucose 6-phosphate metabolic process (GO:0051156)	2.73267671
131	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.71972419
132	regulation of extracellular matrix organization (GO:1903053)	2.68080172
133	protein heterotrimerization (GO:0070208)	2.67521633
134	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.65870952
135	virion attachment to host cell (GO:0019062)	2.64381901
136	adhesion of symbiont to host cell (GO:0044650)	2.64381901
137	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.61343997
138	regulation of apoptotic cell clearance (GO:2000425)	2.61160490
139	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.60091492
140	embryonic process involved in female pregnancy (GO:0060136)	2.58456869
141	embryo implantation (GO:0007566)	2.56689782
142	response to laminar fluid shear stress (GO:0034616)	2.54873053
143	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.51217348
144	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.49784967
145	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.49175157
146	negative regulation of erythrocyte differentiation (GO:0045647)	2.47511927
147	apoptotic process involved in morphogenesis (GO:0060561)	2.46811749
148	positive regulation of osteoblast proliferation (GO:0033690)	2.46495621
149	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.46248438
150	collagen metabolic process (GO:0032963)	2.42957671
151	protein-lipid complex assembly (GO:0065005)	2.41944824
152	positive regulation of receptor recycling (GO:0001921)	2.41446639
153	maternal placenta development (GO:0001893)	2.39686300
154	hypotonic response (GO:0006971)	2.38352864
155	extracellular matrix disassembly (GO:0022617)	2.37337743
156	activation of Rac GTPase activity (GO:0032863)	2.36945801
157	hyaluronan metabolic process (GO:0030212)	2.36425247
158	negative regulation of cell size (GO:0045792)	2.35333984
159	pentose-phosphate shunt (GO:0006098)	2.34611786
160	regulation of cholesterol biosynthetic process (GO:0045540)	2.30647556
161	multicellular organismal macromolecule metabolic process (GO:0044259)	2.29902753
162	negative regulation of protein localization to plasma membrane (GO:1903077)	2.29886739
163	semaphorin-plexin signaling pathway (GO:0071526)	2.29747654
164	plasma lipoprotein particle assembly (GO:0034377)	2.29663702
165	collagen catabolic process (GO:0030574)	2.27479123
166	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.27137565
167	vascular endothelial growth factor signaling pathway (GO:0038084)	2.26687150
168	very-low-density lipoprotein particle assembly (GO:0034379)	2.26433641
169	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.25817578
170	regulation of metalloenzyme activity (GO:0048552)	2.25252894
171	fibril organization (GO:0097435)	2.25090309
172	nucleotide-sugar biosynthetic process (GO:0009226)	2.22100958

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	7.24531622
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.22627401
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.80194156
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.11380015
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.62891365
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.23855411
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.79727697
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.64992757
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.59292083
10	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.35567402
11	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.33254607
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.27567225
13	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.26606612
14	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.22622379
15	CLOCK_20551151_ChIP-Seq_293T_Human	2.22099864
16	VDR_21846776_ChIP-Seq_THP-1_Human	1.99983663
17	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.97395561
18	LXR_22292898_ChIP-Seq_THP-1_Human	1.92645624
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.86674741
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.78492857
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.78335583
22	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.76945496
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74357152
24	GATA1_22025678_ChIP-Seq_K562_Human	1.66858873
25	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.63190166
26	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.58001508
27	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.54999929
28	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.53411836
29	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.52733350
30	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.50840638
31	RACK7_27058665_Chip-Seq_MCF-7_Human	1.48470857
32	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.47252562
33	KDM2B_26808549_Chip-Seq_DND41_Human	1.46169441
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44938067
35	KDM2B_26808549_Chip-Seq_K562_Human	1.40036451
36	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.38907397
37	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.37637064
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.37144893
39	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.35789924
40	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.35257584
41	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.33228401
42	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.31508083
43	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.31194907
44	ATF3_27146783_Chip-Seq_COLON_Human	1.29917148
45	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.29719051
46	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29450524
47	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.28679001
48	MYC_22102868_ChIP-Seq_BL_Human	1.27694240
49	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.27395397
50	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.24878787
51	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.24581962
52	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.24293744
53	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.23658394
54	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.23631913
55	P68_20966046_ChIP-Seq_HELA_Human	1.21980890
56	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.21424694
57	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.21315560
58	VDR_24763502_ChIP-Seq_THP-1_Human	1.20189613
59	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.19772781
60	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.19563813
61	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.17591945
62	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.16536800
63	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.16167863
64	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.15459431
65	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.14733909
66	MAF_26560356_Chip-Seq_TH1_Human	1.14644001
67	GATA6_25053715_ChIP-Seq_YYC3_Human	1.14064299
68	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.13748618
69	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.12707812
70	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.12453217
71	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11416247
72	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.11321891
73	GATA4_25053715_ChIP-Seq_YYC3_Human	1.10903485
74	* TBX20_22080862_ChIP-Seq_HEART_Mouse	1.10780070
75	* TBX20_22328084_ChIP-Seq_HEART_Mouse	1.10780070
76	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.10654585
77	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.10291542
78	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.10262982
79	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.09767879
80	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.09253343
81	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07942452
82	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.07924271
83	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.07801806
84	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.06648669
85	CREB1_26743006_Chip-Seq_LNCaP_Human	1.06300126
86	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.04881460
87	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.04812367
88	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.04026111
89	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.03928208
90	PHF8_20622854_ChIP-Seq_HELA_Human	1.03847593
91	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.03627761
92	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.02558020
93	BCOR_27268052_Chip-Seq_Bcells_Human	1.01925680
94	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.00429297
95	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00405162
96	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.00380564
97	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.00380564
98	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.00354111
99	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.00011763
100	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.99712660
101	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.99685195
102	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.99220489
103	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.98915938
104	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.97189282
105	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.96915372
106	TP63_22573176_ChIP-Seq_HFKS_Human	0.96747258
107	SMC4_20622854_ChIP-Seq_HELA_Human	0.96635326
108	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.95261808
109	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.94842657
110	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.94615262
111	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93385291
112	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92928441
113	E2F7_22180533_ChIP-Seq_HELA_Human	0.92862110
114	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.92564764
115	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.91351104
116	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.89866296
117	NCOR1_26117541_ChIP-Seq_K562_Human	0.89374333
118	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.88651171
119	TP53_22127205_ChIP-Seq_IMR90_Human	0.88564934
120	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.88421114
121	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.87271700
122	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.86796476
123	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.86709952
124	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86678596
125	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.86638779
126	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.86625252
127	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.86097112
128	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.86016308
129	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.85747500
130	ZNF263_19887448_ChIP-Seq_K562_Human	0.84777111
131	CTCF_21964334_Chip-Seq_Bcells_Human	0.84522341
132	TCF7_22412390_ChIP-Seq_EML_Mouse	0.83781857
133	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.82833358
134	CHD1_26751641_Chip-Seq_LNCaP_Human	0.82735669
135	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.82575106
136	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.82534137
137	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.82240046
138	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.81764858
139	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.81328496

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.12308475
2	MP0005365_abnormal_bile_salt	4.85878365
3	MP0005360_urolithiasis	4.24490498
4	MP0005083_abnormal_biliary_tract	3.80067249
5	MP0005085_abnormal_gallbladder_physiolo	3.59856398
6	MP0001666_abnormal_nutrient_absorption	3.33079332
7	MP0003705_abnormal_hypodermis_morpholog	3.13185711
8	MP0009840_abnormal_foam_cell	2.87710819
9	MP0008438_abnormal_cutaneous_collagen	2.70716696
10	MP0005220_abnormal_exocrine_pancreas	2.60652672
11	MP0003252_abnormal_bile_duct	2.53659298
12	MP0005451_abnormal_body_composition	2.51828445
13	MP0003806_abnormal_nucleotide_metabolis	2.43833569
14	MP0003195_calcinosis	2.41435419
15	MP0010329_abnormal_lipoprotein_level	2.27850413
16	MP0005670_abnormal_white_adipose	2.17324229
17	MP0005332_abnormal_amino_acid	2.03978345
18	MP0001958_emphysema	2.01203143
19	MP0008875_abnormal_xenobiotic_pharmacok	2.01187258
20	MP0003868_abnormal_feces_composition	1.88627521
21	MP0005058_abnormal_lysosome_morphology	1.86177010
22	MP0001944_abnormal_pancreas_morphology	1.77557296
23	MP0003091_abnormal_cell_migration	1.76603094
24	MP0003283_abnormal_digestive_organ	1.76105031
25	MP0000013_abnormal_adipose_tissue	1.74637955
26	MP0001849_ear_inflammation	1.74537054
27	MP0004264_abnormal_extraembryonic_tissu	1.68559928
28	MP0004858_abnormal_nervous_system	1.65772768
29	MP0000858_altered_metastatic_potential	1.65306610
30	MP0000609_abnormal_liver_physiology	1.64412557
31	MP0009643_abnormal_urine_homeostasis	1.63561393
32	MP0002118_abnormal_lipid_homeostasis	1.60406034
33	MP0002693_abnormal_pancreas_physiology	1.58752676
34	MP0002837_dystrophic_cardiac_calcinosis	1.57853479
35	MP0002138_abnormal_hepatobiliary_system	1.50688670
36	MP0000767_abnormal_smooth_muscle	1.44048159
37	MP0005623_abnormal_meninges_morphology	1.43509977
38	MP0005409_darkened_coat_color	1.42519745
39	MP0003191_abnormal_cellular_cholesterol	1.41449539
40	MP0008260_abnormal_autophagy	1.41175346
41	MP0004019_abnormal_vitamin_homeostasis	1.40625901
42	MP0003453_abnormal_keratinocyte_physiol	1.39230347
43	MP0004272_abnormal_basement_membrane	1.38393049
44	MP0003950_abnormal_plasma_membrane	1.36402874
45	MP0005319_abnormal_enzyme/_coenzyme	1.35376838
46	MP0005084_abnormal_gallbladder_morpholo	1.33032918
47	MP0003436_decreased_susceptibility_to	1.32607273
48	MP0006054_spinal_hemorrhage	1.32021975
49	MP0009384_cardiac_valve_regurgitation	1.30568429
50	MP0002078_abnormal_glucose_homeostasis	1.30553768
51	MP0010368_abnormal_lymphatic_system	1.28107925
52	MP0000003_abnormal_adipose_tissue	1.27007951
53	MP0003566_abnormal_cell_adhesion	1.25958972
54	MP0002132_abnormal_respiratory_system	1.25316884
55	MP0002909_abnormal_adrenal_gland	1.24951468
56	MP0003300_gastrointestinal_ulcer	1.24045038
57	MP0001348_abnormal_lacrimal_gland	1.23208185
58	MP0008961_abnormal_basal_metabolism	1.22673004
59	MP0003279_aneurysm	1.20977144
60	MP0002796_impaired_skin_barrier	1.20721104
61	MP0009780_abnormal_chondrocyte_physiolo	1.20542305
62	MP0002896_abnormal_bone_mineralization	1.19846721
63	MP0001915_intracranial_hemorrhage	1.15502638
64	MP0004947_skin_inflammation	1.14640928
65	MP0002877_abnormal_melanocyte_morpholog	1.13532616
66	MP0001756_abnormal_urination	1.13382373
67	MP0003183_abnormal_peptide_metabolism	1.12781342
68	MP0005275_abnormal_skin_tensile	1.10137240
69	MP0005375_adipose_tissue_phenotype	1.09823174
70	MP0003172_abnormal_lysosome_physiology	1.09768707
71	MP0000598_abnormal_liver_morphology	1.05624998
72	MP0003303_peritoneal_inflammation	1.04945529
73	MP0005503_abnormal_tendon_morphology	1.04391288
74	MP0005508_abnormal_skeleton_morphology	1.03051510
75	MP0001542_abnormal_bone_strength	1.02460951
76	MP0005666_abnormal_adipose_tissue	1.02352513
77	MP0002269_muscular_atrophy	1.02089382
78	MP0002998_abnormal_bone_remodeling	1.01081707
79	MP0001243_abnormal_dermal_layer	0.99363351
80	MP0009672_abnormal_birth_weight	0.97639569
81	MP0005636_abnormal_mineral_homeostasis	0.97066231
82	MP0003959_abnormal_lean_body	0.96061527
83	MP0000751_myopathy	0.94505295
84	MP0004043_abnormal_pH_regulation	0.94182916
85	MP0000678_abnormal_parathyroid_gland	0.93782432
86	MP0005164_abnormal_response_to	0.93558754
87	MP0005501_abnormal_skin_physiology	0.92821786
88	MP0002933_joint_inflammation	0.92338203
89	MP0001765_abnormal_ion_homeostasis	0.90757625
90	MP0001533_abnormal_skeleton_physiology	0.90716728
91	MP0003941_abnormal_skin_development	0.90619663
92	MP0009333_abnormal_splenocyte_physiolog	0.89606833
93	MP0001764_abnormal_homeostasis	0.88232808
94	MP0005023_abnormal_wound_healing	0.87672222
95	MP0005408_hypopigmentation	0.86051975
96	MP0005448_abnormal_energy_balance	0.85226287
97	MP0005390_skeleton_phenotype	0.85210962
98	MP0005464_abnormal_platelet_physiology	0.84639511
99	MP0001216_abnormal_epidermal_layer	0.84525177
100	MP0004185_abnormal_adipocyte_glucose	0.84047163
101	MP0005410_abnormal_fertilization	0.82938288
102	MP0002089_abnormal_postnatal_growth/wei	0.82739855
103	MP0005621_abnormal_cell_physiology	0.81625858
104	MP0004782_abnormal_surfactant_physiolog	0.81487265
105	MP0005257_abnormal_intraocular_pressure	0.80945628
106	MP0009931_abnormal_skin_appearance	0.80460258
107	MP0000733_abnormal_muscle_development	0.80404989
108	MP0010234_abnormal_vibrissa_follicle	0.79588780
109	MP0002060_abnormal_skin_morphology	0.79542175
110	MP0005076_abnormal_cell_differentiation	0.79403108
111	MP0010030_abnormal_orbit_morphology	0.78798012
112	MP0009642_abnormal_blood_homeostasis	0.78713835
113	MP0005584_abnormal_enzyme/coenzyme_acti	0.78132802
114	MP0002168_other_aberrant_phenotype	0.77972484
115	MP0002108_abnormal_muscle_morphology	0.76895919
116	MP0003953_abnormal_hormone_level	0.75317995
117	MP0002928_abnormal_bile_duct	0.74283309
118	MP0002295_abnormal_pulmonary_circulatio	0.73714713
119	MP0010155_abnormal_intestine_physiology	0.73679235
120	MP0000639_abnormal_adrenal_gland	0.73604178
121	MP0003448_altered_tumor_morphology	0.72554384
122	MP0000467_abnormal_esophagus_morphology	0.72188066
123	MP0005334_abnormal_fat_pad	0.71035549
124	MP0006082_CNS_inflammation	0.70699102
125	MP0002970_abnormal_white_adipose	0.69028682
126	MP0005165_increased_susceptibility_to	0.68626071
127	MP0001614_abnormal_blood_vessel	0.68007611
128	MP0010352_gastrointestinal_tract_polyps	0.67780744
129	MP0001881_abnormal_mammary_gland	0.65993369
130	MP0000685_abnormal_immune_system	0.65899575
131	MP0000759_abnormal_skeletal_muscle	0.65194216
132	MP0000762_abnormal_tongue_morphology	0.64267387
133	MP0002135_abnormal_kidney_morphology	0.63824076
134	MP0000462_abnormal_digestive_system	0.63451506
135	MP0002113_abnormal_skeleton_development	0.63083839
136	MP0003329_amyloid_beta_deposits	0.63060662
137	MP0000249_abnormal_blood_vessel	0.62829742
138	MP0003075_altered_response_to	0.62531708
139	MP0000358_abnormal_cell_content/	0.62464267
140	MP0004233_abnormal_muscle_weight	0.61009567
141	MP0000343_altered_response_to	0.60798835
142	MP0002971_abnormal_brown_adipose	0.60798722
143	MP0002136_abnormal_kidney_physiology	0.60759989
144	MP0009278_abnormal_bone_marrow	0.60494643
145	MP0002254_reproductive_system_inflammat	0.60437224
146	MP0002086_abnormal_extraembryonic_tissu	0.60356076
147	MP0001730_embryonic_growth_arrest	0.60183544
148	MP0010386_abnormal_urinary_bladder	0.59293818
149	MP0000747_muscle_weakness	0.58821285
150	MP0003795_abnormal_bone_structure	0.55615328
151	MP0000163_abnormal_cartilage_morphology	0.54248090
152	MP0003656_abnormal_erythrocyte_physiolo	0.53821621
153	MP0003119_abnormal_digestive_system	0.52269915
154	MP0001661_extended_life_span	0.52086206
155	MP0003638_abnormal_response/metabolism_	0.52031862
156	MP0003115_abnormal_respiratory_system	0.51995183
157	MP0003045_fibrosis	0.51056371
158	MP0004130_abnormal_muscle_cell	0.49178791

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic coma (HP:0001325)	4.65100390
2	Abnormality of the intrinsic pathway (HP:0010989)	4.54570944
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.49324696
4	Deep venous thrombosis (HP:0002625)	4.44663251
5	Hyperinsulinemic hypoglycemia (HP:0000825)	4.08921614
6	Xanthomatosis (HP:0000991)	4.05899819
7	Ketosis (HP:0001946)	3.91272237
8	Ketoacidosis (HP:0001993)	3.91172467
9	Intrahepatic cholestasis (HP:0001406)	3.88131568
10	Hypoglycemic seizures (HP:0002173)	3.87432431
11	Abnormality of the common coagulation pathway (HP:0010990)	3.77906913
12	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.75692120
13	Vertebral compression fractures (HP:0002953)	3.72496345
14	Prolonged partial thromboplastin time (HP:0003645)	3.38000093
15	Late onset (HP:0003584)	3.34110048
16	Protrusio acetabuli (HP:0003179)	3.25659538
17	Aortic dissection (HP:0002647)	3.17921064
18	Fragile skin (HP:0001030)	3.11985350
19	Abnormality of endocrine pancreas physiology (HP:0012093)	3.10574551
20	Abnormality of the pancreatic islet cells (HP:0006476)	3.10574551
21	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.07856764
22	Gout (HP:0001997)	3.06048174
23	Complement deficiency (HP:0004431)	3.03709389
24	Vascular tortuosity (HP:0004948)	3.00791753
25	Urinary glycosaminoglycan excretion (HP:0003541)	3.00470488
26	Mucopolysacchariduria (HP:0008155)	3.00470488
27	Atrophic scars (HP:0001075)	2.97511213
28	Hyperlipoproteinemia (HP:0010980)	2.95267790
29	Dysostosis multiplex (HP:0000943)	2.93607337
30	Hyperglycemia (HP:0003074)	2.89724061
31	Hyperammonemia (HP:0001987)	2.88437377
32	Back pain (HP:0003418)	2.88231268
33	Ankle contracture (HP:0006466)	2.84743382
34	Arterial tortuosity (HP:0005116)	2.84338329
35	Aortic aneurysm (HP:0004942)	2.82618282
36	Hypoalphalipoproteinemia (HP:0003233)	2.78951926
37	Symptomatic seizures (HP:0011145)	2.78419069
38	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.76982088
39	Abnormality of polysaccharide metabolism (HP:0011012)	2.76982088
40	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.76982088
41	Wormian bones (HP:0002645)	2.76266277
42	Bladder diverticulum (HP:0000015)	2.76058420
43	Hypobetalipoproteinemia (HP:0003563)	2.74321628
44	Premature rupture of membranes (HP:0001788)	2.70557866
45	Fat malabsorption (HP:0002630)	2.63413865
46	Hypolipoproteinemia (HP:0010981)	2.60724489
47	Spinal rigidity (HP:0003306)	2.59004029
48	Abnormality of dentin (HP:0010299)	2.57676906
49	Hyperglycinemia (HP:0002154)	2.56996948
50	Cerebral aneurysm (HP:0004944)	2.55906776
51	Dilatation of the ascending aorta (HP:0005111)	2.55703716
52	Protuberant abdomen (HP:0001538)	2.55350144
53	Conjugated hyperbilirubinemia (HP:0002908)	2.51903588
54	Achilles tendon contracture (HP:0001771)	2.50212246
55	Pancreatic islet-cell hyperplasia (HP:0004510)	2.49830935
56	Soft skin (HP:0000977)	2.47827406
57	Disproportionate tall stature (HP:0001519)	2.46314626
58	Cervical subluxation (HP:0003308)	2.46000847
59	Abnormality of the Achilles tendon (HP:0005109)	2.44940330
60	Insulin resistance (HP:0000855)	2.44424075
61	Hyperglycinuria (HP:0003108)	2.42281532
62	Shallow orbits (HP:0000586)	2.40637241
63	Abnormality of purine metabolism (HP:0004352)	2.40065527
64	Follicular hyperkeratosis (HP:0007502)	2.39845130
65	Increased connective tissue (HP:0009025)	2.38603600
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.36516773
67	Abnormality of the acetabulum (HP:0003170)	2.36320119
68	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.35783345
69	Long toe (HP:0010511)	2.35722228
70	Abnormality of complement system (HP:0005339)	2.34604643
71	Elbow flexion contracture (HP:0002987)	2.33901502
72	Peritonitis (HP:0002586)	2.33273114
73	Abdominal distention (HP:0003270)	2.32341334
74	Ulnar bowing (HP:0003031)	2.31717557
75	Retinal atrophy (HP:0001105)	2.28935513
76	Generalized aminoaciduria (HP:0002909)	2.28792470
77	Insulin-resistant diabetes mellitus (HP:0000831)	2.27894002
78	Mildly elevated creatine phosphokinase (HP:0008180)	2.27785151
79	Hemorrhage of the eye (HP:0011885)	2.27508148
80	Spondylolisthesis (HP:0003302)	2.27130216
81	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.26585898
82	Abnormality of fatty-acid metabolism (HP:0004359)	2.25726966
83	Flat acetabular roof (HP:0003180)	2.24679705
84	Increased variability in muscle fiber diameter (HP:0003557)	2.24224723
85	Malnutrition (HP:0004395)	2.23416739
86	Hand muscle atrophy (HP:0009130)	2.23360936
87	Dicarboxylic aciduria (HP:0003215)	2.20966975
88	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.20966975
89	Genu recurvatum (HP:0002816)	2.20934427
90	Abnormality of glycine metabolism (HP:0010895)	2.20078569
91	Abnormality of serine family amino acid metabolism (HP:0010894)	2.20078569
92	Neonatal short-limb short stature (HP:0008921)	2.17160889
93	Joint hemorrhage (HP:0005261)	2.16940696
94	Abnormal delivery (HP:0001787)	2.16556403
95	Abnormality of methionine metabolism (HP:0010901)	2.14928591
96	Asymmetric septal hypertrophy (HP:0001670)	2.14334698
97	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13955126
98	Thin bony cortex (HP:0002753)	2.13859006
99	Hyperacusis (HP:0010780)	2.13786370
100	Skin nodule (HP:0200036)	2.13699641
101	Mitral valve prolapse (HP:0001634)	2.13588757
102	Abnormal tarsal ossification (HP:0008369)	2.13459297
103	Abnormality of carpal bone ossification (HP:0006257)	2.12820891
104	Aneurysm (HP:0002617)	2.12530614
105	Progressive muscle weakness (HP:0003323)	2.12168199
106	Broad face (HP:0000283)	2.11583370
107	Abnormality of nucleobase metabolism (HP:0010932)	2.11344733
108	Cholecystitis (HP:0001082)	2.10821288
109	Abnormal gallbladder physiology (HP:0012438)	2.10821288
110	Severe short stature (HP:0003510)	2.09982081
111	Large for gestational age (HP:0001520)	2.09429304
112	Premature skin wrinkling (HP:0100678)	2.08762549
113	Joint laxity (HP:0001388)	2.07693288
114	Vacuolated lymphocytes (HP:0001922)	2.07610325
115	Hyperextensible skin (HP:0000974)	2.07414676
116	Hypercholesterolemia (HP:0003124)	2.05376335
117	Epidermoid cyst (HP:0200040)	2.05070867
118	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.04911145
119	Osteolytic defects of the hand bones (HP:0009699)	2.04911145
120	Beaking of vertebral bodies (HP:0004568)	2.04836983
121	Mitral regurgitation (HP:0001653)	2.03977570
122	Abnormal pancreas size (HP:0012094)	2.02325914
123	Asymmetry of the thorax (HP:0001555)	2.00339456
124	Myocardial infarction (HP:0001658)	1.99588575
125	Abnormality of skeletal muscle fiber size (HP:0012084)	1.98870146
126	Biconcave vertebral bodies (HP:0004586)	1.97488994
127	Mitral stenosis (HP:0001718)	1.96128898
128	Systemic lupus erythematosus (HP:0002725)	1.95404633
129	Distal lower limb amyotrophy (HP:0008944)	1.95288521
130	Joint stiffness (HP:0001387)	1.94824446
131	Type 1 muscle fiber predominance (HP:0003803)	1.94604953
132	Polycythemia (HP:0001901)	1.94021768
133	Abnormal enzyme/coenzyme activity (HP:0012379)	1.92380327
134	Coxa vara (HP:0002812)	1.92367509
135	Abnormal ossification of hand bones (HP:0005921)	1.92150669
136	Slender build (HP:0001533)	1.91194168
137	Turricephaly (HP:0000262)	1.90808770
138	Pancreatitis (HP:0001733)	1.90629701
139	J-shaped sella turcica (HP:0002680)	1.90471891
140	Distal upper limb amyotrophy (HP:0007149)	1.90309764
141	Upper limb amyotrophy (HP:0009129)	1.90309764
142	Hepatocellular carcinoma (HP:0001402)	1.90288251
143	Enlarged kidneys (HP:0000105)	1.89891468
144	Steatorrhea (HP:0002570)	1.89565108
145	Hyperbilirubinemia (HP:0002904)	1.87151220
146	Natal tooth (HP:0000695)	1.85838299
147	Abnormality of alkaline phosphatase activity (HP:0004379)	1.85729286
148	Myoglobinuria (HP:0002913)	1.85332192
149	Nonimmune hydrops fetalis (HP:0001790)	1.84833540
150	Ectopia lentis (HP:0001083)	1.84352512
151	Generalized amyotrophy (HP:0003700)	1.84290752
152	Short nail (HP:0001799)	1.84211560
153	Cardiovascular calcification (HP:0011915)	1.83299007
154	Trismus (HP:0000211)	1.82033645
155	Emphysema (HP:0002097)	1.81089464
156	Blue sclerae (HP:0000592)	1.80843872
157	Proximal tubulopathy (HP:0000114)	1.80725847
158	Stridor (HP:0010307)	1.80279229
159	Broad metatarsal (HP:0001783)	1.78585046
160	Abnormal cartilage morphology (HP:0002763)	1.78099850
161	Nuclear cataract (HP:0100018)	1.77497805
162	Vascular calcification (HP:0004934)	1.77158594
163	Distal lower limb muscle weakness (HP:0009053)	1.76743023
164	Right ventricular cardiomyopathy (HP:0011663)	1.76584230
165	Advanced eruption of teeth (HP:0006288)	1.76140724
166	Cupped ribs (HP:0000887)	1.72572059
167	Breech presentation (HP:0001623)	1.70421597
168	Obstructive sleep apnea (HP:0002870)	1.66813645
169	Interstitial pulmonary disease (HP:0006530)	1.66136127
170	Ankyloglossia (HP:0010296)	1.65914789
171	Spinal cord lesions (HP:0100561)	1.64574651
172	Syringomyelia (HP:0003396)	1.64574651
173	Venous abnormality (HP:0002624)	1.63950299

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	6.01983445
2	TRIB3	4.84118253
3	BCKDK	4.03867322
4	PKN2	3.17992815
5	SMG1	2.92492244
6	INSRR	2.67764921
7	SIK1	2.64533869
8	PRPF4B	2.42805529
9	TAOK3	2.20862884
10	PTK6	2.01795821
11	PRKD3	2.01277526
12	LATS1	1.94268542
13	FGFR4	1.93806758
14	NME2	1.91955498
15	PASK	1.82013560
16	FLT3	1.75362640
17	IRAK3	1.74084169
18	MAPK15	1.70767300
19	PDGFRA	1.70364393
20	MAP3K10	1.68780595
21	EEF2K	1.66487073
22	PTK2	1.63248958
23	MAP3K3	1.47625429
24	EPHA2	1.42239726
25	ICK	1.40493105
26	PIK3CG	1.35434814
27	DDR2	1.33139188
28	RIPK1	1.32471920
29	FRK	1.29408424
30	PDK4	1.29092658
31	PDK3	1.29092658
32	DYRK1B	1.24784707
33	TESK1	1.24408366
34	MTOR	1.21370901
35	MAPKAPK3	1.17417992
36	TTN	1.17174677
37	MAP3K2	1.16324457
38	TAOK1	1.15783667
39	KSR2	1.14267309
40	MAP2K2	1.11169670
41	SCYL2	1.10359630
42	MET	1.08527244
43	WNK4	1.07481868
44	KDR	1.07447247
45	MAP3K11	1.05359735
46	STK38L	1.03785189
47	CDC42BPA	0.99242358
48	MAPK11	0.98896827
49	TESK2	0.98413765
50	LMTK2	0.94440702
51	MAP3K13	0.92775944
52	FER	0.91261205
53	MAP2K3	0.89454040
54	HIPK2	0.85430871
55	EPHA3	0.83435775
56	BMX	0.81212389
57	PRKG2	0.80364775
58	CAMK1D	0.80361362
59	MAP3K14	0.78848621
60	FGFR3	0.77869837
61	PAK2	0.77722620
62	ARAF	0.77171569
63	PRKCI	0.76078881
64	NEK9	0.74323130
65	PDK2	0.74054953
66	MAP3K1	0.72753938
67	TGFBR2	0.72292833
68	MAP3K6	0.71031772
69	EIF2AK3	0.70837883
70	LATS2	0.68714685
71	TRPM7	0.67541711
72	EPHB1	0.65893747
73	SIK3	0.64061021
74	JAK3	0.63697544
75	MST1R	0.63450674
76	RIPK4	0.62829939
77	LRRK2	0.62573063
78	STK38	0.61930524
79	ILK	0.61740146
80	TAOK2	0.60140388
81	CAMK1G	0.59667293
82	TYK2	0.59176873
83	RET	0.56803432
84	CDK7	0.56571041
85	MARK2	0.56084536
86	PTK2B	0.55971927
87	CDK4	0.55593097
88	MOS	0.54983916
89	CLK1	0.54534841
90	PAK4	0.53246929
91	BRAF	0.53144778
92	IRAK1	0.52851943
93	CDK12	0.51354381
94	MELK	0.50694120
95	AKT3	0.50306956
96	MAPKAPK2	0.50289682
97	EIF2AK1	0.49514125
98	PRKD1	0.48223943
99	ZAP70	0.48135521
100	PINK1	0.47372845
101	PDGFRB	0.46948126
102	RPS6KB2	0.46493453
103	RPS6KA4	0.46462540
104	LIMK1	0.46013100
105	DMPK	0.45779388
106	EPHB2	0.45689570
107	JAK1	0.44861491
108	MAP3K7	0.44544317
109	MAPK7	0.43921189
110	PRKD2	0.42533569
111	MAP2K1	0.42021036
112	JAK2	0.41694539
113	MYLK	0.41529563
114	PDK1	0.41047675
115	IRAK4	0.40040832
116	PRKAA1	0.39967075
117	PAK3	0.38468551
118	MAP3K8	0.37139896
119	PAK1	0.37104567
120	CAMKK1	0.36508079
121	CDK9	0.35452098
122	RPS6KA2	0.35066795
123	RPS6KC1	0.34536657
124	RPS6KL1	0.34536657
125	CDK6	0.34362696
126	ERBB4	0.33213491
127	TBK1	0.32705890
128	FGFR1	0.32477299
129	GSK3A	0.32369379
130	NEK2	0.31128596
131	NTRK1	0.29715575
132	PRKCH	0.27123345
133	BRD4	0.27116189
134	PIM2	0.26004427
135	STK10	0.24630016
136	PDPK1	0.23886196
137	TIE1	0.22809804
138	DAPK3	0.21310173

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.22583335
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.96509619
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.76017268
4	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.69088410
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.45310017
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.37049596
7	Protein export_Homo sapiens_hsa03060	2.34616305
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.32881638
9	Fat digestion and absorption_Homo sapiens_hsa04975	2.30171128
10	Fatty acid degradation_Homo sapiens_hsa00071	2.23753856
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.22147766
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.09392876
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.07389441
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.04728570
15	Arginine biosynthesis_Homo sapiens_hsa00220	2.03965769
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.86344896
17	Complement and coagulation cascades_Homo sapiens_hsa04610	1.83988456
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.82366684
19	Folate biosynthesis_Homo sapiens_hsa00790	1.81023273
20	Propanoate metabolism_Homo sapiens_hsa00640	1.76246056
21	Focal adhesion_Homo sapiens_hsa04510	1.72839971
22	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.72814530
23	Sulfur metabolism_Homo sapiens_hsa00920	1.71432784
24	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.57862516
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.52342665
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.52126225
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.51049519
28	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.50962444
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.47577261
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.44759671
31	Protein digestion and absorption_Homo sapiens_hsa04974	1.42510244
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.40390007
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.39238523
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.38670816
35	Small cell lung cancer_Homo sapiens_hsa05222	1.38472848
36	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.38244667
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.38055481
38	Amoebiasis_Homo sapiens_hsa05146	1.37507042
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.36056880
40	Lysine degradation_Homo sapiens_hsa00310	1.32531836
41	Peroxisome_Homo sapiens_hsa04146	1.30520150
42	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.30502686
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29906309
44	Galactose metabolism_Homo sapiens_hsa00052	1.29102989
45	Pancreatic cancer_Homo sapiens_hsa05212	1.29067014
46	Butanoate metabolism_Homo sapiens_hsa00650	1.28757670
47	Carbon metabolism_Homo sapiens_hsa01200	1.26143563
48	Proteoglycans in cancer_Homo sapiens_hsa05205	1.25831806
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24839591
50	Thyroid cancer_Homo sapiens_hsa05216	1.23471181
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.20446611
52	Bile secretion_Homo sapiens_hsa04976	1.19614066
53	Non-small cell lung cancer_Homo sapiens_hsa05223	1.19363468
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.17272206
55	One carbon pool by folate_Homo sapiens_hsa00670	1.15916690
56	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14683244
57	Pancreatic secretion_Homo sapiens_hsa04972	1.14432745
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13162828
59	VEGF signaling pathway_Homo sapiens_hsa04370	1.12755113
60	Other glycan degradation_Homo sapiens_hsa00511	1.10153419
61	Phenylalanine metabolism_Homo sapiens_hsa00360	1.10008838
62	Arginine and proline metabolism_Homo sapiens_hsa00330	1.09864372
63	Glycerolipid metabolism_Homo sapiens_hsa00561	1.08531648
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.06750596
65	Sulfur relay system_Homo sapiens_hsa04122	1.05120347
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.03036521
67	Histidine metabolism_Homo sapiens_hsa00340	0.98615099
68	Notch signaling pathway_Homo sapiens_hsa04330	0.98430695
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.95775912
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.93594413
71	Adherens junction_Homo sapiens_hsa04520	0.93219660
72	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.91966616
73	TNF signaling pathway_Homo sapiens_hsa04668	0.91418942
74	Lysosome_Homo sapiens_hsa04142	0.90949576
75	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.90635346
76	Prostate cancer_Homo sapiens_hsa05215	0.90246871
77	Hepatitis C_Homo sapiens_hsa05160	0.90197922
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88442968
79	ABC transporters_Homo sapiens_hsa02010	0.88282721
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86555845
81	Insulin resistance_Homo sapiens_hsa04931	0.86497606
82	Toxoplasmosis_Homo sapiens_hsa05145	0.86242353
83	Endometrial cancer_Homo sapiens_hsa05213	0.86088191
84	Malaria_Homo sapiens_hsa05144	0.84826407
85	Hepatitis B_Homo sapiens_hsa05161	0.83179643
86	Renal cell carcinoma_Homo sapiens_hsa05211	0.81454002
87	Pertussis_Homo sapiens_hsa05133	0.80452393
88	Shigellosis_Homo sapiens_hsa05131	0.79590509
89	Insulin secretion_Homo sapiens_hsa04911	0.78540524
90	Caffeine metabolism_Homo sapiens_hsa00232	0.78360589
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.78103814
92	Pentose phosphate pathway_Homo sapiens_hsa00030	0.77743079
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76494520
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76376359
95	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.75811119
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.75528079
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.75395457
98	Glioma_Homo sapiens_hsa05214	0.75106574
99	mTOR signaling pathway_Homo sapiens_hsa04150	0.74954223
100	Apoptosis_Homo sapiens_hsa04210	0.73869111
101	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73226778
102	Renin-angiotensin system_Homo sapiens_hsa04614	0.73107588
103	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72737693
104	MicroRNAs in cancer_Homo sapiens_hsa05206	0.72699010
105	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.70981141
106	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.70688708
107	Retinol metabolism_Homo sapiens_hsa00830	0.70523711
108	Influenza A_Homo sapiens_hsa05164	0.69083643
109	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.68810844
110	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.67713875
111	Osteoclast differentiation_Homo sapiens_hsa04380	0.66587237
112	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65365703
113	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.64034735
114	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.62432476
115	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62164220
116	Endocytosis_Homo sapiens_hsa04144	0.60112722
117	Prolactin signaling pathway_Homo sapiens_hsa04917	0.59975637
118	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.58661417
119	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58187896
120	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56001941
121	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55880016
122	HTLV-I infection_Homo sapiens_hsa05166	0.54938410
123	ErbB signaling pathway_Homo sapiens_hsa04012	0.53120290
124	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52316624
125	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51575686
126	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.51451296
127	Prion diseases_Homo sapiens_hsa05020	0.51422801
128	Salmonella infection_Homo sapiens_hsa05132	0.51414459
129	Bladder cancer_Homo sapiens_hsa05219	0.50127504
130	GnRH signaling pathway_Homo sapiens_hsa04912	0.49796636
131	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47341480
132	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.46733330
133	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46608436
134	Viral carcinogenesis_Homo sapiens_hsa05203	0.45141759
135	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45022674
136	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.44160921
137	ECM-receptor interaction_Homo sapiens_hsa04512	0.42786096
138	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.42150328
139	Metabolic pathways_Homo sapiens_hsa01100	0.39590552
140	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38945879
141	Glutathione metabolism_Homo sapiens_hsa00480	0.36765928
142	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35988303
143	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.34859550
144	Insulin signaling pathway_Homo sapiens_hsa04910	0.34356395
145	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33049719
146	AMPK signaling pathway_Homo sapiens_hsa04152	0.31568723
147	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.29962656
148	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28601988
149	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.28041635
150	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27020122
151	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25902589
152	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22368755
153	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.20492728

TMEM214

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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