TMEM215

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.22095356
2COPI coating of Golgi vesicle (GO:0048205)9.22095356
3sperm motility (GO:0030317)8.76712040
4acrosome reaction (GO:0007340)8.08005682
5chromosome condensation (GO:0030261)7.48113359
6single strand break repair (GO:0000012)7.29768883
7DNA packaging (GO:0006323)7.24771063
8protein maturation by protein folding (GO:0022417)6.70792151
9endocrine pancreas development (GO:0031018)6.66296734
10fusion of sperm to egg plasma membrane (GO:0007342)6.42220116
11spermatid development (GO:0007286)6.35482535
12sperm capacitation (GO:0048240)6.29572360
13protein targeting to Golgi (GO:0000042)6.17747237
14spermatid nucleus differentiation (GO:0007289)6.16056674
15rRNA methylation (GO:0031167)6.14857199
16regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.09639997
17microtubule depolymerization (GO:0007019)5.95919642
18establishment of protein localization to Golgi (GO:0072600)5.91577832
19regulation of type B pancreatic cell apoptotic process (GO:2000674)5.90371548
20vitamin catabolic process (GO:0009111)5.86967943
21fat-soluble vitamin catabolic process (GO:0042363)5.86967943
22microtubule polymerization or depolymerization (GO:0031109)5.78870898
23retrograde transport, vesicle recycling within Golgi (GO:0000301)5.77589223
24peptide hormone processing (GO:0016486)5.74574158
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.51373029
26COPII vesicle coating (GO:0048208)5.49919410
27nitric oxide mediated signal transduction (GO:0007263)5.45426371
28protein polyglutamylation (GO:0018095)5.44647825
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.43506642
30rRNA modification (GO:0000154)5.35205010
31centriole replication (GO:0007099)5.32797718
32insulin secretion (GO:0030073)5.31843858
33glandular epithelial cell differentiation (GO:0002067)5.30855159
34regulation of centriole replication (GO:0046599)5.27845480
35sperm-egg recognition (GO:0035036)5.03524801
36exocrine pancreas development (GO:0031017)4.96901835
37interleukin-6-mediated signaling pathway (GO:0070102)4.87278210
38binding of sperm to zona pellucida (GO:0007339)4.81261484
39plasma membrane fusion (GO:0045026)4.78541468
40protein retention in ER lumen (GO:0006621)4.76440031
41signal peptide processing (GO:0006465)4.75529971
42type B pancreatic cell development (GO:0003323)4.72377178
43positive regulation of insulin secretion (GO:0032024)4.71968165
44galactose catabolic process (GO:0019388)4.62739020
45spermatogenesis (GO:0007283)4.62643394
46male gamete generation (GO:0048232)4.61296311
47calcium ion-dependent exocytosis (GO:0017156)4.59706682
48centriole assembly (GO:0098534)4.53632270
49regulation of insulin secretion (GO:0050796)4.51193901
50activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.49491832
51sequestering of metal ion (GO:0051238)4.48142292
52axonemal dynein complex assembly (GO:0070286)4.46186898
53glandular epithelial cell development (GO:0002068)4.43665005
54seminiferous tubule development (GO:0072520)4.39141087
55gamete generation (GO:0007276)4.31428897
56positive regulation of nuclease activity (GO:0032075)4.25223250
57phosphatidylethanolamine biosynthetic process (GO:0006646)4.24058919
58vesicle coating (GO:0006901)4.23695012
59multicellular organism reproduction (GO:0032504)4.23664003
60negative regulation of glycoprotein biosynthetic process (GO:0010561)4.22567766
61microtubule severing (GO:0051013)4.18764680
62sexual reproduction (GO:0019953)4.13610870
63histone exchange (GO:0043486)4.12933725
64regulation of peptide hormone secretion (GO:0090276)4.09802520
65detection of calcium ion (GO:0005513)4.08531915
66response to pheromone (GO:0019236)4.08447161
67negative regulation of inclusion body assembly (GO:0090084)4.07346729
68reproduction (GO:0000003)4.04944133
69regulation of peptide secretion (GO:0002791)4.02286542
70phosphatidylethanolamine metabolic process (GO:0046337)3.95584779
71cell-cell recognition (GO:0009988)3.95395446
72retinal rod cell development (GO:0046548)3.93245431
73regulation of nuclease activity (GO:0032069)3.85893336
74positive regulation of peptide hormone secretion (GO:0090277)3.85641948
75ER overload response (GO:0006983)3.85317338
76negative regulation of insulin secretion (GO:0046676)3.84339275
77germ cell development (GO:0007281)3.80652138
78detection of light stimulus involved in visual perception (GO:0050908)3.79171443
79detection of light stimulus involved in sensory perception (GO:0050962)3.79171443
80negative regulation of norepinephrine secretion (GO:0010700)3.77825876
81negative regulation of catecholamine secretion (GO:0033604)3.77623725
82peptide hormone secretion (GO:0030072)3.76297614
83positive regulation of peptide secretion (GO:0002793)3.72885282
84regulation of mesoderm development (GO:2000380)3.72320655
85endoplasmic reticulum unfolded protein response (GO:0030968)3.71442190
86regulation of histone H3-K9 methylation (GO:0051570)3.70572051
87chromatin silencing (GO:0006342)3.69461602
88negative regulation of histone methylation (GO:0031061)3.67737471
89peptide secretion (GO:0002790)3.66846953
90intra-Golgi vesicle-mediated transport (GO:0006891)3.66705469
91lactate metabolic process (GO:0006089)3.66436363
92cellular response to unfolded protein (GO:0034620)3.63714168
93cellular response to topologically incorrect protein (GO:0035967)3.58372666
94regulation of hormone secretion (GO:0046883)3.55994840
95regulation of cilium movement (GO:0003352)3.54220319
96positive regulation of glycolytic process (GO:0045821)3.53182461
97RNA destabilization (GO:0050779)3.50871257
98ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.50444843
99ER-nucleus signaling pathway (GO:0006984)3.49603270
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46520157
101genitalia morphogenesis (GO:0035112)3.46163748
102single fertilization (GO:0007338)3.45440005
103multicellular organismal reproductive process (GO:0048609)3.43161120
104retinal cone cell development (GO:0046549)3.41866039
105nucleus organization (GO:0006997)3.41607147
106columnar/cuboidal epithelial cell development (GO:0002066)3.40741956
107cellular process involved in reproduction in multicellular organism (GO:0022412)3.40559547
108musculoskeletal movement (GO:0050881)3.40311609
109multicellular organismal movement (GO:0050879)3.40311609
110regulation of transcription involved in cell fate commitment (GO:0060850)3.37586430
111innervation (GO:0060384)3.34990069
112negative regulation of peptide hormone secretion (GO:0090278)3.34506675
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31874839
114negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28893669
115nuclear pore complex assembly (GO:0051292)3.27321297
116regulation of peptide transport (GO:0090087)3.26790961
117astrocyte differentiation (GO:0048708)3.26044297
118regulation of synaptic vesicle exocytosis (GO:2000300)3.24921913
119cellular response to vitamin D (GO:0071305)3.22193688
120negative regulation of peptide secretion (GO:0002792)3.21787484
121regulation of glucocorticoid secretion (GO:2000849)3.20899502
122negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.19127064
123regulation of Rab GTPase activity (GO:0032313)3.18002631
124positive regulation of Rab GTPase activity (GO:0032851)3.18002631
125inner ear receptor cell development (GO:0060119)3.17849906
126toxin metabolic process (GO:0009404)3.17675461
127protein N-linked glycosylation via asparagine (GO:0018279)3.14969374
128peptidyl-asparagine modification (GO:0018196)3.14425431
129cellular response to glucagon stimulus (GO:0071377)3.14041924
130cellular zinc ion homeostasis (GO:0006882)3.13989311
131negative regulation of glycoprotein metabolic process (GO:1903019)3.10765407
132epithelial cell fate commitment (GO:0072148)3.09297956
133cilium or flagellum-dependent cell motility (GO:0001539)3.09104191
134synaptic vesicle exocytosis (GO:0016079)3.08707410
135negative regulation of Rho protein signal transduction (GO:0035024)3.08342065
136L-alpha-amino acid transmembrane transport (GO:1902475)3.07341603
137macroautophagy (GO:0016236)3.07108489
138microtubule nucleation (GO:0007020)3.07105157
139protein localization to Golgi apparatus (GO:0034067)3.03350176
140positive regulation of hormone secretion (GO:0046887)3.00504576
141negative regulation of gene silencing (GO:0060969)3.00495826
142ER to Golgi vesicle-mediated transport (GO:0006888)2.99812771
143response to endoplasmic reticulum stress (GO:0034976)2.99378039
144epithelial cilium movement (GO:0003351)2.99045850
145response to hexose (GO:0009746)2.96441651
146motile cilium assembly (GO:0044458)2.95040538
147lateral sprouting from an epithelium (GO:0060601)2.93799119
148nucleosome disassembly (GO:0006337)2.92652041
149protein-DNA complex disassembly (GO:0032986)2.92652041
150alanine transport (GO:0032328)2.91929670
151glomerular visceral epithelial cell development (GO:0072015)2.91122778
152fertilization (GO:0009566)2.90774682
153response to glucose (GO:0009749)2.90202298
154DNA conformation change (GO:0071103)2.89549419
155negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.89359755
156peptide transport (GO:0015833)2.89140003
157protein N-linked glycosylation (GO:0006487)2.87815793
158regulation of energy homeostasis (GO:2000505)2.87720569
159positive regulation of exocytosis (GO:0045921)2.87550742
160regulation of inclusion body assembly (GO:0090083)2.87230107
161hormone secretion (GO:0046879)2.86850766
162pancreas development (GO:0031016)2.86556988
163muscle organ morphogenesis (GO:0048644)2.85746541
164relaxation of smooth muscle (GO:0044557)2.84812969
165cerebellar Purkinje cell layer development (GO:0021680)2.82756414
166response to unfolded protein (GO:0006986)2.82293151
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.82055864
168response to monosaccharide (GO:0034284)2.80078603
169urinary tract smooth muscle contraction (GO:0014848)2.79521865
170calcium ion import (GO:0070509)2.79437104
171trivalent inorganic anion homeostasis (GO:0072506)2.79382679
172phosphate ion homeostasis (GO:0055062)2.79382679
173neuronal ion channel clustering (GO:0045161)2.78563299
174ventricular system development (GO:0021591)2.77227091
175response to topologically incorrect protein (GO:0035966)2.77178359
176regulation of hexokinase activity (GO:1903299)2.76841693
177regulation of glucokinase activity (GO:0033131)2.76841693
178histone H3-K9 demethylation (GO:0033169)2.76409183
179regulation of Golgi to plasma membrane protein transport (GO:0042996)2.74960560
180cell communication by electrical coupling (GO:0010644)2.74187999
181synaptic vesicle maturation (GO:0016188)2.72000871
182cell differentiation involved in metanephros development (GO:0072202)2.71455636
183glomerular epithelial cell development (GO:0072310)2.68361914
184vitamin D metabolic process (GO:0042359)2.66813182
185cilium movement (GO:0003341)2.65205798
186left/right axis specification (GO:0070986)2.64076437
187RNA localization (GO:0006403)2.63635460
188nuclear pore organization (GO:0006999)2.63370550
189spinal cord motor neuron differentiation (GO:0021522)2.62751656
190limb bud formation (GO:0060174)2.61479516
191retina layer formation (GO:0010842)2.58244792
192negative regulation of embryonic development (GO:0045992)2.57707210
193positive regulation of skeletal muscle tissue development (GO:0048643)2.55779440
194centrosome duplication (GO:0051298)2.54545033
195receptor recycling (GO:0001881)2.54456954
196cerebral cortex neuron differentiation (GO:0021895)2.52733931
197otic vesicle formation (GO:0030916)2.52092425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.72110572
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.78429133
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.17828233
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.94650802
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.94650802
6GBX2_23144817_ChIP-Seq_PC3_Human2.86390652
7REST_21632747_ChIP-Seq_MESCs_Mouse2.76795245
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69135890
9GATA1_22025678_ChIP-Seq_K562_Human2.61409273
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58927559
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52224669
12IGF1R_20145208_ChIP-Seq_DFB_Human2.41500090
13FUS_26573619_Chip-Seq_HEK293_Human2.35986481
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35225062
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32237198
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.19971256
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.12302691
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08558383
19* CBP_20019798_ChIP-Seq_JUKART_Human2.00161993
20* IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.00161993
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.93180229
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90452110
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81254463
24NR3C1_23031785_ChIP-Seq_PC12_Mouse1.74256824
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71283982
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67510711
27EZH2_22144423_ChIP-Seq_EOC_Human1.66372089
28VDR_22108803_ChIP-Seq_LS180_Human1.65551078
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.65147475
30TAF15_26573619_Chip-Seq_HEK293_Human1.62994623
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62053962
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59911806
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58499598
34AR_21572438_ChIP-Seq_LNCaP_Human1.57649845
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57535226
36DROSHA_22980978_ChIP-Seq_HELA_Human1.57094706
37CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.56718976
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.56717778
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55447564
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.55314238
41SMAD4_21741376_ChIP-Seq_HESCs_Human1.54020202
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53816971
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53238388
44TBL1_22424771_ChIP-Seq_293T_Human1.52491722
45CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50815130
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.49453624
47NFYB_21822215_ChIP-Seq_K562_Human1.49307297
48RBPJ_21746931_ChIP-Seq_IB4_Human1.48876288
49ZNF274_21170338_ChIP-Seq_K562_Hela1.48755174
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.48728890
51ETV1_20927104_ChIP-Seq_GIST48_Human1.48359578
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47216725
53REST_19997604_ChIP-ChIP_NEURONS_Mouse1.46961597
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.44536781
55* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43261465
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42483590
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42478659
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41722844
59STAT3_23295773_ChIP-Seq_U87_Human1.41303100
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41060031
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.40440347
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.39889852
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.39224244
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37095555
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36671573
66* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36368425
67PHF8_20622853_ChIP-Seq_HELA_Human1.35138998
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.35103372
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35022291
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34804082
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32560501
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31205676
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.30816326
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.30557055
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.30385953
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28424247
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.26454969
78NFYA_21822215_ChIP-Seq_K562_Human1.24490958
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23639836
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.22007508
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.21089991
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20703738
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19975100
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18936646
85KDM2B_26808549_Chip-Seq_REH_Human1.18552283
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17513835
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17044038
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16850838
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15491214
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14846008
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14399259
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13859048
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12069630
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11878185
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11379244
96AR_19668381_ChIP-Seq_PC3_Human1.11326176
97ER_23166858_ChIP-Seq_MCF-7_Human1.10821633
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.10537189
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.09220948
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09008249
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08932469
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08267654
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08253823
104KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08245690
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.08075136
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07952656
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07655706
108SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06754088
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06624174
110TP53_22573176_ChIP-Seq_HFKS_Human1.06048603
111TP53_18474530_ChIP-ChIP_U2OS_Human1.05891861
112SOX2_19829295_ChIP-Seq_ESCs_Human1.05569603
113NANOG_19829295_ChIP-Seq_ESCs_Human1.05569603
114RUNX2_22187159_ChIP-Seq_PCA_Human1.05545584
115BCAT_22108803_ChIP-Seq_LS180_Human1.05466216
116TCF4_23295773_ChIP-Seq_U87_Human1.05383847
117NANOG_20526341_ChIP-Seq_ESCs_Human1.05164879
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03911602
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02683907
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.01582372
121* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00895169
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00833035
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00697120
124EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00675080
125RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00675080
126TAF2_19829295_ChIP-Seq_ESCs_Human1.00191383
127RAC3_21632823_ChIP-Seq_H3396_Human1.00161400
128MYC_19829295_ChIP-Seq_ESCs_Human0.98866374
129GATA6_21074721_ChIP-Seq_CACO-2_Human0.98168897
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98052874
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97483447
132* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97425222
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97396867
134SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96042155
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96026875
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95442204
137ERG_20517297_ChIP-Seq_VCAP_Human0.95122659
138VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94531763
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.93405509
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92401073
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92217738
142AR_25329375_ChIP-Seq_VCAP_Human0.90775769
143P300_19829295_ChIP-Seq_ESCs_Human0.89570016
144TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88044849
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87914404
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87365851
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86793561
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86048434
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.85696047
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84039875
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82572396
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81941839
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.81486553
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81420627
155SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80771946
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80310066
157RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80110950
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78905889
159CTCF_27219007_Chip-Seq_Bcells_Human0.78431422
160* NANOG_18555785_Chip-Seq_ESCs_Mouse0.76934275
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.76542922
162TCF4_22108803_ChIP-Seq_LS180_Human0.76055273
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75629586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.86374421
2MP0003878_abnormal_ear_physiology6.86374421
3MP0005410_abnormal_fertilization6.71273542
4MP0003283_abnormal_digestive_organ4.99411819
5MP0004043_abnormal_pH_regulation4.31152096
6MP0002877_abnormal_melanocyte_morpholog4.26354336
7MP0002693_abnormal_pancreas_physiology4.05139266
8MP0010386_abnormal_urinary_bladder4.01871225
9MP0009780_abnormal_chondrocyte_physiolo3.95501905
10MP0002909_abnormal_adrenal_gland3.93130822
11MP0006072_abnormal_retinal_apoptosis3.71680506
12MP0001944_abnormal_pancreas_morphology3.64092777
13MP0000013_abnormal_adipose_tissue3.43571599
14MP0005379_endocrine/exocrine_gland_phen2.94092628
15MP0005220_abnormal_exocrine_pancreas2.87092337
16MP0003195_calcinosis2.86405455
17MP0000678_abnormal_parathyroid_gland2.84438317
18MP0003698_abnormal_male_reproductive2.76226061
19MP0003183_abnormal_peptide_metabolism2.67111653
20MP0002102_abnormal_ear_morphology2.56567681
21MP0005551_abnormal_eye_electrophysiolog2.50875450
22MP0001929_abnormal_gametogenesis2.40842089
23MP0005646_abnormal_pituitary_gland2.30433731
24MP0002837_dystrophic_cardiac_calcinosis2.25429825
25MP0002078_abnormal_glucose_homeostasis2.25341274
26MP0002638_abnormal_pupillary_reflex2.13617967
27MP0002234_abnormal_pharynx_morphology2.10645062
28MP0001485_abnormal_pinna_reflex2.07998961
29MP0003136_yellow_coat_color1.99736149
30MP0001502_abnormal_circadian_rhythm1.97099802
31MP0005253_abnormal_eye_physiology1.96656229
32MP0004742_abnormal_vestibular_system1.94032173
33MP0004859_abnormal_synaptic_plasticity1.93934399
34MP0002090_abnormal_vision1.90585159
35MP0001984_abnormal_olfaction1.86728481
36MP0001348_abnormal_lacrimal_gland1.81231097
37MP0001986_abnormal_taste_sensitivity1.80789028
38MP0009053_abnormal_anal_canal1.79873487
39MP0001764_abnormal_homeostasis1.78262500
40MP0002822_catalepsy1.72398388
41MP0005423_abnormal_somatic_nervous1.67222484
42MP0008877_abnormal_DNA_methylation1.63065378
43MP0002161_abnormal_fertility/fecundity1.58993296
44MP0002928_abnormal_bile_duct1.56823837
45MP0000003_abnormal_adipose_tissue1.56024027
46MP0003172_abnormal_lysosome_physiology1.53773980
47MP0006292_abnormal_olfactory_placode1.48711686
48MP0000631_abnormal_neuroendocrine_gland1.48468867
49MP0003122_maternal_imprinting1.48069653
50MP0004270_analgesia1.45362903
51MP0000462_abnormal_digestive_system1.44732966
52MP0004264_abnormal_extraembryonic_tissu1.44378797
53MP0004957_abnormal_blastocyst_morpholog1.38780114
54MP0003868_abnormal_feces_composition1.38608018
55MP0008961_abnormal_basal_metabolism1.38493421
56MP0004885_abnormal_endolymph1.36150353
57MP0001486_abnormal_startle_reflex1.35334918
58MP0003953_abnormal_hormone_level1.33648040
59MP0001963_abnormal_hearing_physiology1.32839865
60MP0001765_abnormal_ion_homeostasis1.28898829
61MP0005645_abnormal_hypothalamus_physiol1.26956341
62MP0001968_abnormal_touch/_nociception1.23781705
63MP0000026_abnormal_inner_ear1.20925857
64MP0005535_abnormal_body_temperature1.19259710
65MP0002210_abnormal_sex_determination1.16667071
66MP0002736_abnormal_nociception_after1.16249303
67MP0003879_abnormal_hair_cell1.15757160
68MP0001145_abnormal_male_reproductive1.13340567
69MP0003937_abnormal_limbs/digits/tail_de1.12788102
70MP0002896_abnormal_bone_mineralization1.08700337
71MP0002734_abnormal_mechanical_nocicepti1.08576541
72MP0004233_abnormal_muscle_weight1.08520475
73MP0000613_abnormal_salivary_gland1.07741583
74MP0003718_maternal_effect1.07273078
75MP0004145_abnormal_muscle_electrophysio1.06587738
76MP0003646_muscle_fatigue1.05928022
77MP0004782_abnormal_surfactant_physiolog1.02700686
78MP0000049_abnormal_middle_ear1.02227541
79MP0002163_abnormal_gland_morphology1.01853572
80MP0003880_abnormal_central_pattern0.99994017
81MP0002229_neurodegeneration0.99840045
82MP0002697_abnormal_eye_size0.99612607
83MP0004036_abnormal_muscle_relaxation0.97355276
84MP0000653_abnormal_sex_gland0.97340642
85MP0010030_abnormal_orbit_morphology0.97151269
86MP0005248_abnormal_Harderian_gland0.95890104
87MP0003635_abnormal_synaptic_transmissio0.95719993
88MP0003959_abnormal_lean_body0.95425941
89MP0000230_abnormal_systemic_arterial0.95400653
90MP0002876_abnormal_thyroid_physiology0.95018292
91MP0002089_abnormal_postnatal_growth/wei0.93795964
92MP0002160_abnormal_reproductive_system0.92659131
93MP0001346_abnormal_lacrimal_gland0.91697267
94MP0003890_abnormal_embryonic-extraembry0.89206094
95MP0002272_abnormal_nervous_system0.88962172
96MP0001293_anophthalmia0.88867871
97MP0002282_abnormal_trachea_morphology0.88862212
98MP0002735_abnormal_chemical_nociception0.88519796
99MP0005310_abnormal_salivary_gland0.88086201
100MP0001270_distended_abdomen0.87980486
101MP0003567_abnormal_fetal_cardiomyocyte0.87353417
102MP0003011_delayed_dark_adaptation0.86522069
103MP0003300_gastrointestinal_ulcer0.86218925
104MP0001661_extended_life_span0.85926804
105MP0005257_abnormal_intraocular_pressure0.85921932
106MP0002751_abnormal_autonomic_nervous0.85454914
107MP0003119_abnormal_digestive_system0.85141833
108MP0009643_abnormal_urine_homeostasis0.84971948
109MP0000762_abnormal_tongue_morphology0.82028952
110MP0003077_abnormal_cell_cycle0.81830063
111MP0003938_abnormal_ear_development0.79525864
112MP0005499_abnormal_olfactory_system0.79067636
113MP0005394_taste/olfaction_phenotype0.79067636
114MP0002653_abnormal_ependyma_morphology0.78471449
115MP0002132_abnormal_respiratory_system0.78375872
116MP0005195_abnormal_posterior_eye0.77983078
117MP0002932_abnormal_joint_morphology0.77842755
118MP0005448_abnormal_energy_balance0.76299113
119MP0005670_abnormal_white_adipose0.76235857
120MP0000639_abnormal_adrenal_gland0.76176784
121MP0001299_abnormal_eye_distance/0.75567291
122MP0005058_abnormal_lysosome_morphology0.75487006
123MP0005187_abnormal_penis_morphology0.75048771
124MP0001286_abnormal_eye_development0.73899046
125MP0003866_abnormal_defecation0.73471824
126MP0005171_absent_coat_pigmentation0.72955550
127MP0000955_abnormal_spinal_cord0.72913487
128MP0008569_lethality_at_weaning0.72697256
129MP0001188_hyperpigmentation0.72503534
130MP0001440_abnormal_grooming_behavior0.71406702
131MP0004019_abnormal_vitamin_homeostasis0.71216752
132MP0002069_abnormal_eating/drinking_beha0.70689181
133MP0001340_abnormal_eyelid_morphology0.70044830
134MP0003941_abnormal_skin_development0.69899032
135MP0001756_abnormal_urination0.69354299
136MP0003787_abnormal_imprinting0.68164084
137MP0005636_abnormal_mineral_homeostasis0.67870374
138MP0005365_abnormal_bile_salt0.66639402
139MP0000372_irregular_coat_pigmentation0.66340265
140MP0002572_abnormal_emotion/affect_behav0.66034313
141MP0003861_abnormal_nervous_system0.65988989
142MP0002249_abnormal_larynx_morphology0.65855930
143MP0000534_abnormal_ureter_morphology0.65431197
144MP0002752_abnormal_somatic_nervous0.64655648
145MP0001970_abnormal_pain_threshold0.64064463
146MP0005391_vision/eye_phenotype0.64038470
147MP0002064_seizures0.63226899
148MP0002733_abnormal_thermal_nociception0.63224706
149MP0003942_abnormal_urinary_system0.62752702
150MP0003693_abnormal_embryo_hatching0.62433681
151MP0001664_abnormal_digestion0.62287658
152MP0002085_abnormal_embryonic_tissue0.61481208
153MP0003385_abnormal_body_wall0.61410010
154MP0002067_abnormal_sensory_capabilities0.61152621
155MP0009745_abnormal_behavioral_response0.61072086
156MP0001324_abnormal_eye_pigmentation0.60776910
157MP0005666_abnormal_adipose_tissue0.60419989
158MP0009672_abnormal_birth_weight0.60384871
159MP0008932_abnormal_embryonic_tissue0.59292932
160MP0004085_abnormal_heartbeat0.59041125
161MP0001501_abnormal_sleep_pattern0.58842431
162MP0000428_abnormal_craniofacial_morphol0.58063195
163MP0002063_abnormal_learning/memory/cond0.57828058
164MP0002557_abnormal_social/conspecific_i0.57759630
165MP0003252_abnormal_bile_duct0.56601796
166MP0003634_abnormal_glial_cell0.54842442
167MP0002184_abnormal_innervation0.54800275
168MP0002882_abnormal_neuron_morphology0.54734311
169MP0000681_abnormal_thyroid_gland0.53871604
170MP0000538_abnormal_urinary_bladder0.52898513

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)9.70823002
2Hyperinsulinemic hypoglycemia (HP:0000825)7.74985672
3Hypoglycemic seizures (HP:0002173)7.22379081
4Symptomatic seizures (HP:0011145)6.77197336
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.15179415
6Hypoglycemic coma (HP:0001325)6.04226361
7Congenital stationary night blindness (HP:0007642)5.76992849
8Insulin-resistant diabetes mellitus (HP:0000831)5.06454384
9Tubulointerstitial nephritis (HP:0001970)4.43080825
10Abnormality of the pancreatic islet cells (HP:0006476)4.33636000
11Abnormality of endocrine pancreas physiology (HP:0012093)4.33636000
12Pancreatic islet-cell hyperplasia (HP:0004510)4.26231100
13Hyperglycemia (HP:0003074)4.23261822
14Large for gestational age (HP:0001520)4.22296476
15Decreased circulating renin level (HP:0003351)4.12820467
16Abnormality of calcium-phosphate metabolism (HP:0100530)4.00144482
17Ketoacidosis (HP:0001993)3.97819213
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.91159422
19Absent/shortened dynein arms (HP:0200106)3.91159422
20Generalized aminoaciduria (HP:0002909)3.65747860
21Abnormal pancreas size (HP:0012094)3.61440846
22Late onset (HP:0003584)3.49015330
23Mucopolysacchariduria (HP:0008155)3.42730837
24Urinary glycosaminoglycan excretion (HP:0003541)3.42730837
25Hypoplasia of the fovea (HP:0007750)3.39896771
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.39896771
27Abnormal rod and cone electroretinograms (HP:0008323)3.34943409
28Central scotoma (HP:0000603)3.31771450
29Resting tremor (HP:0002322)3.29444812
30Osteomalacia (HP:0002749)3.29376332
31Abnormal respiratory motile cilium physiology (HP:0012261)3.28638357
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.27995885
33Abnormality of polysaccharide metabolism (HP:0011012)3.21259696
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.21259696
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.21259696
36Dysostosis multiplex (HP:0000943)3.17055460
37Abnormal ciliary motility (HP:0012262)3.16455880
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15763083
39Hypokalemia (HP:0002900)3.11188854
40Visual hallucinations (HP:0002367)3.04078076
41Bell-shaped thorax (HP:0001591)3.00087619
42Abnormality of the fovea (HP:0000493)2.99504493
43Male infertility (HP:0003251)2.98868793
44EEG with generalized epileptiform discharges (HP:0011198)2.90503635
45Abnormal respiratory motile cilium morphology (HP:0005938)2.88587448
46Abnormal respiratory epithelium morphology (HP:0012253)2.88587448
47Cone-rod dystrophy (HP:0000548)2.84314093
48Severe visual impairment (HP:0001141)2.84292209
49Impulsivity (HP:0100710)2.83186266
50Epileptiform EEG discharges (HP:0011182)2.82119643
51Abnormality of macular pigmentation (HP:0008002)2.81987661
52Vascular calcification (HP:0004934)2.80902031
53Abnormality of renal resorption (HP:0011038)2.80559979
54Premature ovarian failure (HP:0008209)2.77003592
55Insulin resistance (HP:0000855)2.76126409
56Abnormality of the dental pulp (HP:0006479)2.72716725
57Abnormality of the dental root (HP:0006486)2.71875146
58Taurodontia (HP:0000679)2.71875146
59Abnormality of permanent molar morphology (HP:0011071)2.71875146
60Asymmetric septal hypertrophy (HP:0001670)2.70887436
61Sensory axonal neuropathy (HP:0003390)2.67585481
62Postural instability (HP:0002172)2.64595971
63Volvulus (HP:0002580)2.64154184
64Agitation (HP:0000713)2.61091913
65Hypsarrhythmia (HP:0002521)2.60703388
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59941488
67Abnormality of renin-angiotensin system (HP:0000847)2.54747337
68Septo-optic dysplasia (HP:0100842)2.54353147
69Abnormality of the parathyroid morphology (HP:0011766)2.53083215
70Bony spicule pigmentary retinopathy (HP:0007737)2.51256776
71Hypergonadotropic hypogonadism (HP:0000815)2.51100490
72Abnormality of molar (HP:0011077)2.50971281
73Abnormality of molar morphology (HP:0011070)2.50971281
74Potter facies (HP:0002009)2.50773355
75Facial shape deformation (HP:0011334)2.50773355
76Hypoalphalipoproteinemia (HP:0003233)2.50447077
77Infertility (HP:0000789)2.48041177
78Abnormality of the intrinsic pathway (HP:0010989)2.46728520
79Abnormality of potassium homeostasis (HP:0011042)2.45853289
80Decreased central vision (HP:0007663)2.43610035
81Optic nerve hypoplasia (HP:0000609)2.41947888
82Cardiovascular calcification (HP:0011915)2.39926003
83Aplasia involving bones of the extremities (HP:0009825)2.37902581
84Aplasia involving bones of the upper limbs (HP:0009823)2.37902581
85Aplasia of the phalanges of the hand (HP:0009802)2.37902581
86Progressive sensorineural hearing impairment (HP:0000408)2.35856628
87Mixed hearing impairment (HP:0000410)2.35546763
88Epileptic encephalopathy (HP:0200134)2.32851555
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32837093
90Hyperactive renin-angiotensin system (HP:0000841)2.32822016
91Limb hypertonia (HP:0002509)2.31805995
92Subcapsular cataract (HP:0000523)2.29360996
93Hyperparathyroidism (HP:0000843)2.27873016
94Hyperkalemia (HP:0002153)2.27793124
95Congenital sensorineural hearing impairment (HP:0008527)2.27448027
96Prominent metopic ridge (HP:0005487)2.26256887
97Cortical visual impairment (HP:0100704)2.23859759
98Ketosis (HP:0001946)2.22701919
99Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.22650735
100Rhinitis (HP:0012384)2.22164301
101Hypothermia (HP:0002045)2.21282323
102Conjugated hyperbilirubinemia (HP:0002908)2.20971967
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18851360
104Gout (HP:0001997)2.18635939
105Type II diabetes mellitus (HP:0005978)2.17955975
106Aplasia/Hypoplasia affecting the retina (HP:0008061)2.16074697
107Nephronophthisis (HP:0000090)2.14819139
108Aplasia/Hypoplasia of the macula (HP:0008059)2.13952046
109Chronic bronchitis (HP:0004469)2.11626112
110Retinal atrophy (HP:0001105)2.10219036
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.08817436
112Stage 5 chronic kidney disease (HP:0003774)2.08466205
113Myokymia (HP:0002411)2.06921931
114Truncal obesity (HP:0001956)2.06716838
115Congenital malformation of the right heart (HP:0011723)2.06533092
116Double outlet right ventricle (HP:0001719)2.06533092
117Failure to thrive in infancy (HP:0001531)2.06475653
118Progressive cerebellar ataxia (HP:0002073)2.04547518
119Abnormal protein glycosylation (HP:0012346)2.03842702
120Abnormal glycosylation (HP:0012345)2.03842702
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03842702
122Abnormal protein N-linked glycosylation (HP:0012347)2.03842702
123Abnormal spermatogenesis (HP:0008669)2.03799012
124Pheochromocytoma (HP:0002666)2.03461865
125Primary adrenal insufficiency (HP:0008207)2.01598064
126Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.00785909
127Abnormality of renal excretion (HP:0011036)2.00590964
128Renovascular hypertension (HP:0100817)1.99588920
129Hyperphosphatemia (HP:0002905)1.99514167
130Unilateral renal agenesis (HP:0000122)1.98378379
131Increased cerebral lipofuscin (HP:0011813)1.97493560
132Esophageal atresia (HP:0002032)1.97300357
133Dysautonomia (HP:0002459)1.97115399
134Oligodactyly (hands) (HP:0001180)1.96640344
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95989055
136Scotoma (HP:0000575)1.95050540
137Abdominal distention (HP:0003270)1.94960669
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94507630
139Thoracolumbar scoliosis (HP:0002944)1.94189592
140Oligodactyly (HP:0012165)1.92405890
141Abnormality of the metopic suture (HP:0005556)1.91362610
142Progressive neurologic deterioration (HP:0002344)1.91064248
143Abnormality of the aortic arch (HP:0012303)1.90592443
144Nephritis (HP:0000123)1.89675024
145Myoglobinuria (HP:0002913)1.89289118
146Hypercortisolism (HP:0001578)1.87615841
147Exocrine pancreatic insufficiency (HP:0001738)1.87264458
148Polar cataract (HP:0010696)1.85886027
149Anophthalmia (HP:0000528)1.85493780
150Midline defect of the nose (HP:0004122)1.85310145
151Menstrual irregularities (HP:0000858)1.84785145
152Tubulointerstitial abnormality (HP:0001969)1.83666529
153Abnormality of the parietal bone (HP:0002696)1.83466605
154Pendular nystagmus (HP:0012043)1.83369445
155Absence seizures (HP:0002121)1.82782067
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80142933
157Impaired vibration sensation in the lower limbs (HP:0002166)1.79895505
158Enlarged epiphyses (HP:0010580)1.79188017
159Papilledema (HP:0001085)1.78673134
160Intestinal atresia (HP:0011100)1.78210276
161Abnormality of the pubic bones (HP:0003172)1.75086649
162Rickets (HP:0002748)1.75085267
163Protuberant abdomen (HP:0001538)1.74612648
164Type II lissencephaly (HP:0007260)1.74529371
165Recurrent corneal erosions (HP:0000495)1.73633237
166Abnormality of the renal medulla (HP:0100957)1.73043833
167Hyperphosphaturia (HP:0003109)1.71407339
168Abnormality of abdominal situs (HP:0011620)1.70860249
169Abdominal situs inversus (HP:0003363)1.70860249
170Hypophosphatemia (HP:0002148)1.70741863
171Hypoplastic ischia (HP:0003175)1.70718805
172Abnormality of the middle phalanges of the toes (HP:0010183)1.70048529
173Nasal polyposis (HP:0100582)1.69978920
174Attenuation of retinal blood vessels (HP:0007843)1.69718225
175Abnormal urine phosphate concentration (HP:0012599)1.69266326
176Congenital primary aphakia (HP:0007707)1.68996824
177Abnormality of purine metabolism (HP:0004352)1.68925569
178Gait imbalance (HP:0002141)1.68686033
179Neoplasm of the heart (HP:0100544)1.68495374
180Abnormality of small intestinal villus morphology (HP:0011472)1.68337685
181Villous atrophy (HP:0011473)1.68337685
182Abnormality of the ischium (HP:0003174)1.67351328
183Neoplasm of striated muscle (HP:0009728)1.67282574
184Depression (HP:0000716)1.67149428
185Restlessness (HP:0000711)1.67102931
186Chorioretinal atrophy (HP:0000533)1.66824571
187Increased circulating renin level (HP:0000848)1.66212797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.48343098
2INSRR8.40786064
3PASK6.43254311
4TESK13.74248419
5PLK23.70701613
6MAPK153.57031693
7PNCK3.39248762
8TAOK33.26989664
9HIPK23.19239953
10PRKD33.04761890
11DDR22.66580061
12FRK2.48087618
13FLT32.34949589
14ACVR1B2.30001067
15MAP3K22.16943422
16CDC72.12155322
17NTRK12.09988179
18ERN12.02660924
19CAMKK22.01936428
20NTRK31.67661278
21CDK121.66763283
22MAP4K21.65295309
23STK38L1.60962540
24MAP3K91.60135947
25BMPR1B1.58916418
26IRAK11.55779784
27EPHA31.52095757
28VRK11.51373378
29MAP3K11.51192317
30TRIM281.44164400
31CDK191.39814127
32AKT31.38405858
33TAF11.35714368
34TNIK1.30893657
35MST41.28237480
36SCYL21.27842451
37CDC42BPA1.27226317
38PRKD21.26775975
39WNK41.23186693
40UHMK11.19841130
41LATS21.18988438
42PLK31.16226046
43MAP3K41.14452625
44TYRO31.06895107
45PRKCH1.05295789
46IRAK31.03590727
47CDK71.02607906
48PDGFRA1.01896091
49PTK21.00575168
50MET0.99547458
51PAK30.94249540
52DYRK1B0.94115605
53DYRK1A0.93709366
54BRSK20.92907545
55MKNK20.87578291
56PRKCE0.85858524
57WNK30.85344160
58IRAK20.83835900
59PTK60.83182633
60PDK10.82518632
61RIPK10.82368084
62BCKDK0.80624380
63VRK20.78799213
64PDPK10.78738544
65CAMK2D0.78246577
66MST1R0.78134612
67BRAF0.75364924
68PIK3CG0.74889169
69CAMKK10.74801632
70FER0.74000476
71PRPF4B0.73582758
72CDK30.71164924
73SIK10.70760839
74PRKAA10.70732473
75PAK60.70563249
76TTK0.70462659
77BUB10.68752808
78PLK10.68176306
79PBK0.66068953
80EPHA40.63844935
81MAP2K70.60915345
82CDK50.58655251
83OXSR10.57736570
84BRD40.56749220
85ERBB40.56434678
86PTK2B0.56273082
87MAP3K100.54917881
88EIF2AK30.54212771
89STK390.54145166
90JAK20.53439168
91CDK10.53158843
92STK380.53047320
93CDK20.52489763
94WEE10.52175785
95MKNK10.51759552
96EPHB20.50583251
97SGK10.50507692
98MOS0.50223478
99CHEK10.48823631
100RET0.48701006
101SGK4940.47932397
102SGK2230.47932397
103ARAF0.47534689
104FGFR20.46437045
105NEK20.45770293
106CDK80.45624794
107CASK0.45616565
108SRPK10.44865951
109NME10.44434502
110DYRK20.44144680
111MAP2K20.43011775
112PRKACA0.42666186
113PRKG20.42173684
114MAP3K80.41985792
115MARK20.41976058
116CHEK20.41907469
117BRSK10.41727695
118RPS6KA10.41053795
119PRKCG0.40099888
120PRKACG0.39974232
121MAPKAPK50.39613566
122NTRK20.38338030
123CAMK1D0.38236028
124RPS6KC10.38089343
125RPS6KL10.38089343
126PRKCI0.37473087
127DYRK30.37452741
128GRK50.36681101
129TIE10.36315292
130PRKCA0.35026159
131ITK0.34261904
132WNK10.34205881
133NEK60.33525808
134CSNK1A10.33437826
135MAPK10.33021427
136MINK10.32873884
137ERBB30.32726151
138MAPK140.32685025
139RPS6KA20.32650003
140MAPK100.32459717
141MARK10.32031012
142DAPK20.31978758
143CDK11A0.31670939
144CCNB10.31443875
145CAMK2B0.31408892
146BMPR20.31303771
147PRKG10.30941840
148JAK10.30560721
149CAMK1G0.30460179
150SGK20.30193767
151RPS6KA60.30064778
152KSR20.29827212
153PRKDC0.28955647
154RPS6KA30.28819779
155SGK30.27727087
156MAPK80.27450745
157PRKCB0.27376384
158MTOR0.27282027
159PRKD10.25242786
160TEC0.24695511
161RPS6KB10.24617110
162PHKG20.24291464
163PHKG10.24291464
164MAPK90.22941887
165CAMK2A0.22889711
166GSK3B0.21954288
167PINK10.20966206
168TRIB30.19718710
169CDK90.19703662

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.46863712
2Protein export_Homo sapiens_hsa030604.69410591
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.62404734
4Fatty acid biosynthesis_Homo sapiens_hsa000613.74039077
5Insulin secretion_Homo sapiens_hsa049113.54669104
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.74174038
7Sulfur metabolism_Homo sapiens_hsa009202.64814894
8Type II diabetes mellitus_Homo sapiens_hsa049302.50257005
9Fatty acid degradation_Homo sapiens_hsa000712.29862740
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.15751993
11RNA transport_Homo sapiens_hsa030132.12167174
12Vibrio cholerae infection_Homo sapiens_hsa051102.10319646
13Hedgehog signaling pathway_Homo sapiens_hsa043402.04882340
14Synaptic vesicle cycle_Homo sapiens_hsa047211.97825332
15GABAergic synapse_Homo sapiens_hsa047271.84447790
16Circadian rhythm_Homo sapiens_hsa047101.83021763
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75826521
18Type I diabetes mellitus_Homo sapiens_hsa049401.73736992
19Homologous recombination_Homo sapiens_hsa034401.62842900
20N-Glycan biosynthesis_Homo sapiens_hsa005101.61685578
21Taste transduction_Homo sapiens_hsa047421.61290629
22Cocaine addiction_Homo sapiens_hsa050301.59331672
23Oocyte meiosis_Homo sapiens_hsa041141.58858458
24Mismatch repair_Homo sapiens_hsa034301.54728073
25Morphine addiction_Homo sapiens_hsa050321.50171195
26Basal transcription factors_Homo sapiens_hsa030221.50021143
27Circadian entrainment_Homo sapiens_hsa047131.47010078
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42799556
29Fatty acid metabolism_Homo sapiens_hsa012121.39160823
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38966342
31Base excision repair_Homo sapiens_hsa034101.36256211
32Basal cell carcinoma_Homo sapiens_hsa052171.33726832
33Collecting duct acid secretion_Homo sapiens_hsa049661.31965612
34Wnt signaling pathway_Homo sapiens_hsa043101.31819948
35Vitamin B6 metabolism_Homo sapiens_hsa007501.27155108
36Pyruvate metabolism_Homo sapiens_hsa006201.26234675
37Nicotine addiction_Homo sapiens_hsa050331.25300052
38Selenocompound metabolism_Homo sapiens_hsa004501.24945162
39Lysosome_Homo sapiens_hsa041421.24741297
40Amphetamine addiction_Homo sapiens_hsa050311.24430909
41Non-homologous end-joining_Homo sapiens_hsa034501.20878738
42Tyrosine metabolism_Homo sapiens_hsa003501.19392270
43Galactose metabolism_Homo sapiens_hsa000521.19051981
44Sulfur relay system_Homo sapiens_hsa041221.16981290
45Serotonergic synapse_Homo sapiens_hsa047261.16306327
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.16057854
47Cholinergic synapse_Homo sapiens_hsa047251.15742393
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15344820
49Melanoma_Homo sapiens_hsa052181.13739001
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13170031
51Pancreatic secretion_Homo sapiens_hsa049721.11104736
52Dopaminergic synapse_Homo sapiens_hsa047281.11009562
53Fanconi anemia pathway_Homo sapiens_hsa034601.10070422
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08063649
55Glucagon signaling pathway_Homo sapiens_hsa049221.05539578
56Regulation of autophagy_Homo sapiens_hsa041401.05012482
57Tight junction_Homo sapiens_hsa045301.03529655
58RNA polymerase_Homo sapiens_hsa030201.00131467
59Renin secretion_Homo sapiens_hsa049240.99982860
60Nitrogen metabolism_Homo sapiens_hsa009100.99457338
61Cell cycle_Homo sapiens_hsa041100.97779715
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97773869
63Huntingtons disease_Homo sapiens_hsa050160.94766464
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94351628
65Nucleotide excision repair_Homo sapiens_hsa034200.93201821
66Other glycan degradation_Homo sapiens_hsa005110.92498804
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91698206
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89842095
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89017562
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88810667
71Long-term potentiation_Homo sapiens_hsa047200.87890049
72Hippo signaling pathway_Homo sapiens_hsa043900.86381482
73Melanogenesis_Homo sapiens_hsa049160.86342894
74Fructose and mannose metabolism_Homo sapiens_hsa000510.84468846
75Insulin resistance_Homo sapiens_hsa049310.83692362
76ABC transporters_Homo sapiens_hsa020100.82547996
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81585264
78Thyroid hormone synthesis_Homo sapiens_hsa049180.81513700
79Spliceosome_Homo sapiens_hsa030400.79140380
80Prolactin signaling pathway_Homo sapiens_hsa049170.77419593
81DNA replication_Homo sapiens_hsa030300.76983200
82Biosynthesis of amino acids_Homo sapiens_hsa012300.76806201
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.76565520
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76226394
85Adherens junction_Homo sapiens_hsa045200.74441793
86Glutamatergic synapse_Homo sapiens_hsa047240.73689327
87Carbon metabolism_Homo sapiens_hsa012000.71957688
88Purine metabolism_Homo sapiens_hsa002300.70016076
89Dorso-ventral axis formation_Homo sapiens_hsa043200.69521607
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.67411668
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66882937
92Vitamin digestion and absorption_Homo sapiens_hsa049770.65285428
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64855734
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63970972
95Alcoholism_Homo sapiens_hsa050340.63576392
96ECM-receptor interaction_Homo sapiens_hsa045120.62708899
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61558938
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61225791
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.59142893
100mRNA surveillance pathway_Homo sapiens_hsa030150.59085387
101Propanoate metabolism_Homo sapiens_hsa006400.59006875
102Fat digestion and absorption_Homo sapiens_hsa049750.58080588
103Sphingolipid metabolism_Homo sapiens_hsa006000.57841903
104Tryptophan metabolism_Homo sapiens_hsa003800.57724750
105Folate biosynthesis_Homo sapiens_hsa007900.57337683
106Salivary secretion_Homo sapiens_hsa049700.56997441
107Estrogen signaling pathway_Homo sapiens_hsa049150.56090958
108TGF-beta signaling pathway_Homo sapiens_hsa043500.55650446
109Olfactory transduction_Homo sapiens_hsa047400.55502694
110Retinol metabolism_Homo sapiens_hsa008300.54293879
111Prion diseases_Homo sapiens_hsa050200.53745777
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50032759
113cAMP signaling pathway_Homo sapiens_hsa040240.49709303
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49541151
115Phototransduction_Homo sapiens_hsa047440.48563828
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47095744
117Butanoate metabolism_Homo sapiens_hsa006500.46939944
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46799718
119Arginine biosynthesis_Homo sapiens_hsa002200.46465598
120MAPK signaling pathway_Homo sapiens_hsa040100.45908716
121Inositol phosphate metabolism_Homo sapiens_hsa005620.45849128
122Oxytocin signaling pathway_Homo sapiens_hsa049210.45842639
123Arginine and proline metabolism_Homo sapiens_hsa003300.45814425
124mTOR signaling pathway_Homo sapiens_hsa041500.45200838
125Starch and sucrose metabolism_Homo sapiens_hsa005000.45186994
126Gap junction_Homo sapiens_hsa045400.44870746
127Insulin signaling pathway_Homo sapiens_hsa049100.44576876
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43808804
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42868589
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42689511
131Phenylalanine metabolism_Homo sapiens_hsa003600.42018497
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.41099730
133Thyroid cancer_Homo sapiens_hsa052160.40919339
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40732638
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36390123
136Long-term depression_Homo sapiens_hsa047300.34718573
137AMPK signaling pathway_Homo sapiens_hsa041520.34412731
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33980486
139Linoleic acid metabolism_Homo sapiens_hsa005910.30056561
140Calcium signaling pathway_Homo sapiens_hsa040200.28667438
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27954568
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27827814
143Dilated cardiomyopathy_Homo sapiens_hsa054140.25690880
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25564860
145Mineral absorption_Homo sapiens_hsa049780.25530767
146Cardiac muscle contraction_Homo sapiens_hsa042600.25179329
147GnRH signaling pathway_Homo sapiens_hsa049120.22956168
148Gastric acid secretion_Homo sapiens_hsa049710.22538960
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22201332
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22154163
151Lysine degradation_Homo sapiens_hsa003100.21026407
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20516813
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20468554
154Protein digestion and absorption_Homo sapiens_hsa049740.19334517
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19053301
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17401845
157Ovarian steroidogenesis_Homo sapiens_hsa049130.16697213

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