TMEM216

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69475855
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.22716286
3DNA deamination (GO:0045006)5.15761999
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14884738
5rRNA modification (GO:0000154)4.58994575
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.56051052
7termination of RNA polymerase III transcription (GO:0006386)4.56051052
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53696060
9ATP synthesis coupled proton transport (GO:0015986)4.53696060
10protein complex biogenesis (GO:0070271)4.32063671
11ribosomal small subunit biogenesis (GO:0042274)4.21879072
12cytochrome complex assembly (GO:0017004)4.21800175
13rRNA methylation (GO:0031167)4.12846339
14spliceosomal snRNP assembly (GO:0000387)4.10341392
15maturation of SSU-rRNA (GO:0030490)4.09998113
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09473069
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.08871527
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.08871527
19mitochondrial respiratory chain complex assembly (GO:0033108)4.08708556
20protein neddylation (GO:0045116)4.06263530
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.01823842
22pseudouridine synthesis (GO:0001522)4.01518558
23viral mRNA export from host cell nucleus (GO:0046784)3.99426888
24guanosine-containing compound biosynthetic process (GO:1901070)3.97389431
25DNA replication checkpoint (GO:0000076)3.95843873
26nucleobase biosynthetic process (GO:0046112)3.95084767
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92801587
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.92801587
29NADH dehydrogenase complex assembly (GO:0010257)3.92801587
30viral transcription (GO:0019083)3.91813879
31DNA strand elongation involved in DNA replication (GO:0006271)3.89832135
32translational termination (GO:0006415)3.89006353
33ribosome biogenesis (GO:0042254)3.87122838
34electron transport chain (GO:0022900)3.87038022
35respiratory electron transport chain (GO:0022904)3.86609546
36purine nucleobase biosynthetic process (GO:0009113)3.86013512
37ribonucleoprotein complex biogenesis (GO:0022613)3.85222678
387-methylguanosine mRNA capping (GO:0006370)3.85183731
39telomere maintenance via semi-conservative replication (GO:0032201)3.84858751
40RNA capping (GO:0036260)3.84365645
417-methylguanosine RNA capping (GO:0009452)3.84365645
42protein deneddylation (GO:0000338)3.80349128
43DNA strand elongation (GO:0022616)3.78547679
44formation of translation preinitiation complex (GO:0001731)3.76552863
45kinetochore assembly (GO:0051382)3.76337888
46CENP-A containing nucleosome assembly (GO:0034080)3.75637601
47DNA replication initiation (GO:0006270)3.73448929
48regulation of cellular amino acid metabolic process (GO:0006521)3.70591384
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66960051
50maturation of 5.8S rRNA (GO:0000460)3.66407003
51mitotic metaphase plate congression (GO:0007080)3.65367013
52rRNA processing (GO:0006364)3.63592103
53cotranslational protein targeting to membrane (GO:0006613)3.60245809
54spliceosomal complex assembly (GO:0000245)3.57990394
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57507688
56protein targeting to ER (GO:0045047)3.55582167
57GTP biosynthetic process (GO:0006183)3.54960933
58chromatin remodeling at centromere (GO:0031055)3.54789466
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.53605242
60GMP metabolic process (GO:0046037)3.50912220
61kinetochore organization (GO:0051383)3.49637545
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49464987
63rRNA metabolic process (GO:0016072)3.48759931
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48021007
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48021007
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48021007
67telomere maintenance via recombination (GO:0000722)3.47469737
68ribosomal large subunit biogenesis (GO:0042273)3.45696617
69translational elongation (GO:0006414)3.44871970
70protein localization to endoplasmic reticulum (GO:0070972)3.43236473
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41964774
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41964774
73cellular component biogenesis (GO:0044085)3.39061915
74cullin deneddylation (GO:0010388)3.37537007
75translational initiation (GO:0006413)3.35047524
76mannosylation (GO:0097502)3.33633455
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31953796
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31929795
79UTP biosynthetic process (GO:0006228)3.31414862
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.28915670
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28915670
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28880157
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.28418027
84inner mitochondrial membrane organization (GO:0007007)3.27335678
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27162352
86chaperone-mediated protein transport (GO:0072321)3.26645190
87base-excision repair, AP site formation (GO:0006285)3.25410751
88regulation of mitotic spindle checkpoint (GO:1903504)3.24561797
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24561797
90pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.24112061
91deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.24002233
92termination of RNA polymerase I transcription (GO:0006363)3.23912700
93deoxyribonucleotide biosynthetic process (GO:0009263)3.23474276
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22611147
95transcription elongation from RNA polymerase I promoter (GO:0006362)3.22241211
96transcription-coupled nucleotide-excision repair (GO:0006283)3.20500548
97translation (GO:0006412)3.19786182
98cellular protein complex disassembly (GO:0043624)3.19590304
99transcription from RNA polymerase I promoter (GO:0006360)3.18804116
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18603879
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17619511
102DNA double-strand break processing (GO:0000729)3.17187823
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17073330
104replication fork processing (GO:0031297)3.16477206
105histone mRNA metabolic process (GO:0008334)3.15420959
106DNA replication-independent nucleosome assembly (GO:0006336)3.14301297
107DNA replication-independent nucleosome organization (GO:0034724)3.14301297
108DNA-templated transcription, termination (GO:0006353)3.12347338
109establishment of integrated proviral latency (GO:0075713)3.12009857
110positive regulation of ligase activity (GO:0051351)3.12006268
111deoxyribose phosphate biosynthetic process (GO:0046385)3.09716439
1122-deoxyribonucleotide biosynthetic process (GO:0009265)3.09716439
113mitotic recombination (GO:0006312)3.08524524
114peptidyl-histidine modification (GO:0018202)3.07755226
115viral life cycle (GO:0019058)3.06830292
116RNA methylation (GO:0001510)3.06793068
117iron-sulfur cluster assembly (GO:0016226)3.06730371
118metallo-sulfur cluster assembly (GO:0031163)3.06730371
119protein targeting to mitochondrion (GO:0006626)3.06524931
120platelet dense granule organization (GO:0060155)3.05845605
121telomere maintenance via telomere lengthening (GO:0010833)3.04852592
122CTP biosynthetic process (GO:0006241)3.04562874
123CTP metabolic process (GO:0046036)3.04562874
124tRNA methylation (GO:0030488)3.04098621
125establishment of chromosome localization (GO:0051303)3.03491132
126nucleobase-containing small molecule interconversion (GO:0015949)3.03300546
127proteasome assembly (GO:0043248)3.02301686
128respiratory chain complex IV assembly (GO:0008535)3.01862804
129metaphase plate congression (GO:0051310)3.01276459
130regulation of ubiquitin-protein transferase activity (GO:0051438)3.00486225
131DNA catabolic process, exonucleolytic (GO:0000738)2.97775608
132DNA-templated transcription, elongation (GO:0006354)2.97187922
133transcription elongation from RNA polymerase II promoter (GO:0006368)2.97091611
134ncRNA processing (GO:0034470)2.96773381
135intracellular protein transmembrane import (GO:0044743)2.96483734
136establishment of protein localization to mitochondrion (GO:0072655)2.95173595
137regulation of double-strand break repair via homologous recombination (GO:0010569)2.94837857
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94234659
139negative regulation of ligase activity (GO:0051352)2.94234659
140regulation of mitochondrial translation (GO:0070129)2.92325122
141DNA damage response, detection of DNA damage (GO:0042769)2.92197717
142ribosome assembly (GO:0042255)2.91361356
143pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90655626
144histone exchange (GO:0043486)2.89876144
145regulation of ligase activity (GO:0051340)2.88843019
146regulation of helicase activity (GO:0051095)2.84986344
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.83454110
148protein localization to mitochondrion (GO:0070585)2.81640627
149aldehyde catabolic process (GO:0046185)2.81212221
150establishment of viral latency (GO:0019043)2.79478585
151tRNA processing (GO:0008033)2.79257729
152water-soluble vitamin biosynthetic process (GO:0042364)2.79194612
153UTP metabolic process (GO:0046051)2.76638313
154purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75915567
155ubiquinone biosynthetic process (GO:0006744)2.75767886
156DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74474142
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.73454208
158purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71314196
159oxidative phosphorylation (GO:0006119)2.69104394
160pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67742452
161negative regulation of protein ubiquitination (GO:0031397)2.67145022
162antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66759759
163regulation of cellular amine metabolic process (GO:0033238)2.64074860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.78751426
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49835344
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.14023425
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88550685
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.71445818
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66354451
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41688070
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37304078
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35243884
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21086671
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17181016
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03586112
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98974373
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97168377
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87215794
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78480754
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77631884
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75826308
19VDR_23849224_ChIP-Seq_CD4+_Human2.74404345
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72789097
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65686924
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60395806
23ZNF274_21170338_ChIP-Seq_K562_Hela2.54932509
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52072653
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.37850179
26ELK1_19687146_ChIP-ChIP_HELA_Human2.36018274
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.33401930
28DCP1A_22483619_ChIP-Seq_HELA_Human2.28120586
29XRN2_22483619_ChIP-Seq_HELA_Human2.24451753
30FOXP3_21729870_ChIP-Seq_TREG_Human2.22624959
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18265294
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18014871
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16043583
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10654265
35* GABP_19822575_ChIP-Seq_HepG2_Human2.09585063
36TTF2_22483619_ChIP-Seq_HELA_Human2.04680329
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03742767
38THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00462987
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97168194
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97112362
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96269754
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.95749777
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94381912
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87942283
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87250154
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85758316
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83758527
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80871998
49FUS_26573619_Chip-Seq_HEK293_Human1.74840814
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69357355
51AR_21909140_ChIP-Seq_LNCAP_Human1.68650108
52CIITA_25753668_ChIP-Seq_RAJI_Human1.66133358
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65847382
54IGF1R_20145208_ChIP-Seq_DFB_Human1.65497407
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.64696887
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64425759
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62553123
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51502133
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51126684
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.51112784
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50202877
62VDR_22108803_ChIP-Seq_LS180_Human1.41843841
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40990441
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40702346
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38841461
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35833584
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33738250
68P300_19829295_ChIP-Seq_ESCs_Human1.33659897
69TAF15_26573619_Chip-Seq_HEK293_Human1.31571354
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30687736
71MYC_18940864_ChIP-ChIP_HL60_Human1.29113239
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28086676
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26356779
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.24884620
75TP53_22573176_ChIP-Seq_HFKS_Human1.22726261
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21932166
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.21635730
78KDM5A_27292631_Chip-Seq_BREAST_Human1.20150326
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.19770328
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18833887
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.18423680
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18173271
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16357795
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14833766
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12539684
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12119700
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10123132
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09773382
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09105140
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.09087485
91AR_20517297_ChIP-Seq_VCAP_Human1.05802131
92NANOG_19829295_ChIP-Seq_ESCs_Human1.04616437
93SOX2_19829295_ChIP-Seq_ESCs_Human1.04616437
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00846929
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00728962
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.00728962
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99927818
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97885648
99* SPI1_23547873_ChIP-Seq_NB4_Human0.96819773
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95712655
101* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95620604
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94750458
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91948572
104* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91464100
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91030757
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90432026
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90309225
108HTT_18923047_ChIP-ChIP_STHdh_Human0.86327180
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85940815
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83948600
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83402278
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83072215
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82931554
114ER_23166858_ChIP-Seq_MCF-7_Human0.82620393
115NANOG_20526341_ChIP-Seq_ESCs_Human0.79607137
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76621797
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76373685
118IRF1_19129219_ChIP-ChIP_H3396_Human0.76089035
119EWS_26573619_Chip-Seq_HEK293_Human0.75511885
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74487805
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74316444
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72085384
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70999323
124TFEB_21752829_ChIP-Seq_HELA_Human0.70817326
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68761880
126GATA1_26923725_Chip-Seq_HPCs_Mouse0.68162179
127* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.66965794
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.63448377
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63150714
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.60096256
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.59007614
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.58778416
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.57966276
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.56371100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.24992439
2MP0010094_abnormal_chromosome_stability3.70524086
3MP0004957_abnormal_blastocyst_morpholog3.52035818
4MP0003077_abnormal_cell_cycle3.40555018
5MP0006292_abnormal_olfactory_placode3.35016385
6MP0009379_abnormal_foot_pigmentation3.33750250
7MP0003111_abnormal_nucleus_morphology3.27274805
8MP0008058_abnormal_DNA_repair3.01400998
9MP0003123_paternal_imprinting2.85550921
10MP0008007_abnormal_cellular_replicative2.78216285
11MP0006072_abnormal_retinal_apoptosis2.77925645
12MP0008057_abnormal_DNA_replication2.76373000
13MP0004147_increased_porphyrin_level2.51119628
14MP0002254_reproductive_system_inflammat2.27698163
15MP0008932_abnormal_embryonic_tissue2.27623107
16MP0003806_abnormal_nucleotide_metabolis2.25112751
17MP0003786_premature_aging2.22037979
18MP0003718_maternal_effect2.12793696
19MP0002396_abnormal_hematopoietic_system2.01897636
20MP0008875_abnormal_xenobiotic_pharmacok1.97330797
21MP0008789_abnormal_olfactory_epithelium1.92067412
22MP0001293_anophthalmia1.90653378
23MP0001188_hyperpigmentation1.85037168
24MP0003186_abnormal_redox_activity1.84494853
25MP0003195_calcinosis1.73845835
26MP0002132_abnormal_respiratory_system1.72570398
27MP0002138_abnormal_hepatobiliary_system1.69651991
28MP0002102_abnormal_ear_morphology1.67247693
29MP0002837_dystrophic_cardiac_calcinosis1.66485676
30MP0005253_abnormal_eye_physiology1.64767680
31MP0001545_abnormal_hematopoietic_system1.60535448
32MP0005397_hematopoietic_system_phenotyp1.60535448
33MP0001968_abnormal_touch/_nociception1.56797191
34MP0003787_abnormal_imprinting1.55321355
35MP0004808_abnormal_hematopoietic_stem1.55265393
36MP0005551_abnormal_eye_electrophysiolog1.54774599
37MP0004133_heterotaxia1.46564713
38MP0003121_genomic_imprinting1.46431076
39MP0002736_abnormal_nociception_after1.45621185
40MP0000566_synostosis1.43546309
41MP0009333_abnormal_splenocyte_physiolog1.42656511
42MP0008877_abnormal_DNA_methylation1.42422824
43MP0002277_abnormal_respiratory_mucosa1.41380146
44MP0005499_abnormal_olfactory_system1.40496060
45MP0005394_taste/olfaction_phenotype1.40496060
46MP0000490_abnormal_crypts_of1.37982488
47MP0002876_abnormal_thyroid_physiology1.36158669
48MP0002160_abnormal_reproductive_system1.35943083
49MP0003136_yellow_coat_color1.35292981
50MP0000350_abnormal_cell_proliferation1.31347552
51MP0000678_abnormal_parathyroid_gland1.31043271
52MP0000049_abnormal_middle_ear1.30735115
53MP0002938_white_spotting1.29806095
54MP0000516_abnormal_urinary_system1.28441005
55MP0005367_renal/urinary_system_phenotyp1.28441005
56MP0003315_abnormal_perineum_morphology1.28148163
57MP0001984_abnormal_olfaction1.28062346
58MP0003890_abnormal_embryonic-extraembry1.27300109
59MP0008872_abnormal_physiological_respon1.26630146
60MP0009697_abnormal_copulation1.25655773
61MP0001730_embryonic_growth_arrest1.24823158
62MP0002653_abnormal_ependyma_morphology1.21810015
63MP0008995_early_reproductive_senescence1.21184297
64MP0005075_abnormal_melanosome_morpholog1.17689362
65MP0000681_abnormal_thyroid_gland1.17331949
66MP0001529_abnormal_vocalization1.16409029
67MP0006036_abnormal_mitochondrial_physio1.15590008
68MP0001485_abnormal_pinna_reflex1.14205256
69MP0000313_abnormal_cell_death1.12478817
70MP0002210_abnormal_sex_determination1.12153059
71MP0002095_abnormal_skin_pigmentation1.11260473
72MP0004142_abnormal_muscle_tone1.10833577
73MP0005389_reproductive_system_phenotype1.10565855
74MP0005410_abnormal_fertilization1.08840064
75MP0009046_muscle_twitch1.08083279
76MP0005645_abnormal_hypothalamus_physiol1.07947315
77MP0003183_abnormal_peptide_metabolism1.06478243
78MP0005332_abnormal_amino_acid1.04805864
79MP0003763_abnormal_thymus_physiology1.02695099
80MP0002233_abnormal_nose_morphology1.01939217
81MP0001697_abnormal_embryo_size1.00407932
82MP0002638_abnormal_pupillary_reflex1.00339826
83MP0002009_preneoplasia0.99716601
84MP0005084_abnormal_gallbladder_morpholo0.98509899
85MP0000569_abnormal_digit_pigmentation0.98427293
86MP0002234_abnormal_pharynx_morphology0.98185685
87MP0001873_stomach_inflammation0.98123313
88MP0001119_abnormal_female_reproductive0.96028752
89MP0005408_hypopigmentation0.95483227
90MP0005379_endocrine/exocrine_gland_phen0.95360498
91MP0005671_abnormal_response_to0.94570676
92MP0001145_abnormal_male_reproductive0.93577104
93MP0003880_abnormal_central_pattern0.93460933
94MP0003119_abnormal_digestive_system0.92629770
95MP0001764_abnormal_homeostasis0.92536395
96MP0006035_abnormal_mitochondrial_morpho0.92232082
97MP0002282_abnormal_trachea_morphology0.91348809
98MP0002751_abnormal_autonomic_nervous0.90780787
99MP0001929_abnormal_gametogenesis0.90392365
100MP0000372_irregular_coat_pigmentation0.90016455
101MP0005395_other_phenotype0.89081084
102MP0003011_delayed_dark_adaptation0.89001847
103MP0003878_abnormal_ear_physiology0.88826517
104MP0005377_hearing/vestibular/ear_phenot0.88826517
105MP0000653_abnormal_sex_gland0.88741137
106MP0003724_increased_susceptibility_to0.88265013
107MP0002085_abnormal_embryonic_tissue0.88141575
108MP0002080_prenatal_lethality0.87992199
109MP0005380_embryogenesis_phenotype0.87711878
110MP0001672_abnormal_embryogenesis/_devel0.87711878
111MP0002019_abnormal_tumor_incidence0.87159856
112MP0003567_abnormal_fetal_cardiomyocyte0.86985466
113MP0001919_abnormal_reproductive_system0.86710791
114MP0000631_abnormal_neuroendocrine_gland0.84679394
115MP0003137_abnormal_impulse_conducting0.83508893
116MP0001286_abnormal_eye_development0.83098846
117MP0005174_abnormal_tail_pigmentation0.81867238
118MP0005646_abnormal_pituitary_gland0.81711761
119MP0002398_abnormal_bone_marrow0.81481102
120MP0000358_abnormal_cell_content/0.79364837
121MP0000647_abnormal_sebaceous_gland0.78875645
122MP0005391_vision/eye_phenotype0.78769608
123MP0003937_abnormal_limbs/digits/tail_de0.78349085
124MP0001727_abnormal_embryo_implantation0.77347974
125MP0003938_abnormal_ear_development0.76580561
126MP0006276_abnormal_autonomic_nervous0.76578147
127MP0002693_abnormal_pancreas_physiology0.76486734
128MP0006054_spinal_hemorrhage0.75325230
129MP0003943_abnormal_hepatobiliary_system0.75146979
130MP0002249_abnormal_larynx_morphology0.74896607
131MP0000703_abnormal_thymus_morphology0.74825070
132MP0001905_abnormal_dopamine_level0.74087768
133MP0005636_abnormal_mineral_homeostasis0.73201739
134MP0003122_maternal_imprinting0.72127417
135MP0001986_abnormal_taste_sensitivity0.71757851
136MP0003984_embryonic_growth_retardation0.70980428
137MP0001853_heart_inflammation0.69736932
138MP0003646_muscle_fatigue0.69218971
139MP0000015_abnormal_ear_pigmentation0.68759684
140MP0002722_abnormal_immune_system0.68755910
141MP0000689_abnormal_spleen_morphology0.68651785
142MP0002163_abnormal_gland_morphology0.66809457
143MP0002088_abnormal_embryonic_growth/wei0.66106624
144MP0000858_altered_metastatic_potential0.65145888

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.43428930
2Abnormality of cells of the erythroid lineage (HP:0012130)5.37670795
3Birth length less than 3rd percentile (HP:0003561)4.53989995
4Reticulocytopenia (HP:0001896)4.24456610
5Thrombocytosis (HP:0001894)3.99129159
6Aplastic anemia (HP:0001915)3.91984865
7Type I transferrin isoform profile (HP:0003642)3.44414761
8Acute necrotizing encephalopathy (HP:0006965)3.29150217
9Renal Fanconi syndrome (HP:0001994)3.17934452
1011 pairs of ribs (HP:0000878)3.16033315
11Chromsome breakage (HP:0040012)3.15606697
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15136874
13Cerebral edema (HP:0002181)3.07871441
14Abnormal mitochondria in muscle tissue (HP:0008316)2.98530893
15Reduced antithrombin III activity (HP:0001976)2.92490045
16Mitochondrial inheritance (HP:0001427)2.87322548
17Increased CSF lactate (HP:0002490)2.85085677
18Type 2 muscle fiber atrophy (HP:0003554)2.84884914
19* Pancreatic fibrosis (HP:0100732)2.82887181
20Microretrognathia (HP:0000308)2.82687731
21Increased intramyocellular lipid droplets (HP:0012240)2.81114124
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.74713880
23Breast hypoplasia (HP:0003187)2.69141656
24Pallor (HP:0000980)2.67622286
25Patellar aplasia (HP:0006443)2.66183219
26Muscle fiber atrophy (HP:0100295)2.65807080
27Degeneration of anterior horn cells (HP:0002398)2.64914887
28Abnormality of the anterior horn cell (HP:0006802)2.64914887
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64214316
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64214316
31Meckel diverticulum (HP:0002245)2.61583897
32Abnormality of the labia minora (HP:0012880)2.61548362
33* True hermaphroditism (HP:0010459)2.59593368
34Hepatocellular necrosis (HP:0001404)2.59477831
35Oral leukoplakia (HP:0002745)2.59356583
363-Methylglutaconic aciduria (HP:0003535)2.58382690
37Aplasia/Hypoplasia of the patella (HP:0006498)2.58215454
38Congenital stationary night blindness (HP:0007642)2.55995062
39Progressive macrocephaly (HP:0004481)2.55966801
40Rough bone trabeculation (HP:0100670)2.55025624
41Acute encephalopathy (HP:0006846)2.53105552
42Optic disc pallor (HP:0000543)2.50869534
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49280585
44Abnormality of the ileum (HP:0001549)2.48894998
45Macrocytic anemia (HP:0001972)2.47077282
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45413303
47Abnormality of the preputium (HP:0100587)2.45354093
48Colon cancer (HP:0003003)2.44275026
49Congenital, generalized hypertrichosis (HP:0004540)2.40296328
50Exertional dyspnea (HP:0002875)2.39547622
51* Abnormality of midbrain morphology (HP:0002418)2.39297855
52* Molar tooth sign on MRI (HP:0002419)2.39297855
53Facial cleft (HP:0002006)2.36584787
54Abnormal respiratory motile cilium physiology (HP:0012261)2.36487933
55Exercise intolerance (HP:0003546)2.35901482
56Methylmalonic acidemia (HP:0002912)2.35220467
57Thyroid-stimulating hormone excess (HP:0002925)2.34814599
58Bone marrow hypocellularity (HP:0005528)2.34271639
59Increased serum lactate (HP:0002151)2.34261570
60Premature graying of hair (HP:0002216)2.33356248
61Pancytopenia (HP:0001876)2.32681734
62Myelodysplasia (HP:0002863)2.31275398
63* Pancreatic cysts (HP:0001737)2.30686166
64Abnormal ciliary motility (HP:0012262)2.30374612
65Increased muscle lipid content (HP:0009058)2.29735863
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27879917
67Abnormal protein N-linked glycosylation (HP:0012347)2.27879917
68Abnormal protein glycosylation (HP:0012346)2.27879917
69Abnormal glycosylation (HP:0012345)2.27879917
70Abolished electroretinogram (ERG) (HP:0000550)2.26767620
71Methylmalonic aciduria (HP:0012120)2.26190552
72Supernumerary spleens (HP:0009799)2.25364319
73Abnormality of chromosome stability (HP:0003220)2.25048941
74CNS hypomyelination (HP:0003429)2.23964251
75Abnormal respiratory motile cilium morphology (HP:0005938)2.22755426
76Abnormal respiratory epithelium morphology (HP:0012253)2.22755426
77Hepatic necrosis (HP:0002605)2.22507536
78Increased hepatocellular lipid droplets (HP:0006565)2.20767144
79Cellular immunodeficiency (HP:0005374)2.18047288
80Cleft eyelid (HP:0000625)2.17916266
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.17035008
82Lethargy (HP:0001254)2.16462877
83Lactic acidosis (HP:0003128)2.15978562
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14418702
85Absent thumb (HP:0009777)2.11630952
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11150002
87Selective tooth agenesis (HP:0001592)2.02713646
88Triphalangeal thumb (HP:0001199)2.02188983
89Hyperglycinuria (HP:0003108)1.97949712
90Abnormality of renal resorption (HP:0011038)1.97574085
91Lipid accumulation in hepatocytes (HP:0006561)1.95371984
92Rhinitis (HP:0012384)1.94278427
93Neoplasm of the adrenal gland (HP:0100631)1.93376927
94* Nephronophthisis (HP:0000090)1.93338931
95Respiratory difficulties (HP:0002880)1.93047140
96Abnormal trabecular bone morphology (HP:0100671)1.92935438
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92103821
98IgM deficiency (HP:0002850)1.91741993
99Carpal bone hypoplasia (HP:0001498)1.90310477
100Short tibia (HP:0005736)1.90181454
101Abnormal lung lobation (HP:0002101)1.89181608
102Abnormality of urine glucose concentration (HP:0011016)1.88254865
103Glycosuria (HP:0003076)1.88254865
104Abnormality of the renal collecting system (HP:0004742)1.86882105
105Hypothermia (HP:0002045)1.86870359
106Abnormal rod and cone electroretinograms (HP:0008323)1.86537592
107Absent/shortened dynein arms (HP:0200106)1.86505814
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.86505814
109Aplasia/Hypoplasia of the spleen (HP:0010451)1.86492812
110Small intestinal stenosis (HP:0012848)1.86492051
111Duodenal stenosis (HP:0100867)1.86492051
112Leukodystrophy (HP:0002415)1.85047607
113Impulsivity (HP:0100710)1.84439444
114Septo-optic dysplasia (HP:0100842)1.84283688
115Chronic bronchitis (HP:0004469)1.83988075
116Abnormality of glycolysis (HP:0004366)1.83683030
117Increased serum pyruvate (HP:0003542)1.83683030
118Clubbing of toes (HP:0100760)1.83376899
119Duplicated collecting system (HP:0000081)1.83352456
120Abnormality of glycine metabolism (HP:0010895)1.82633170
121Abnormality of serine family amino acid metabolism (HP:0010894)1.82633170
122Aplasia/hypoplasia of the uterus (HP:0008684)1.82323121
123Median cleft lip (HP:0000161)1.81790956
124Abnormal spermatogenesis (HP:0008669)1.80838979
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80206659
126Hyperglycinemia (HP:0002154)1.79983256
127Pendular nystagmus (HP:0012043)1.79466353
128Respiratory failure (HP:0002878)1.78085255
129Palpitations (HP:0001962)1.77916024
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.77252931
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76789309
132Abnormality of the duodenum (HP:0002246)1.76490012
133* Sloping forehead (HP:0000340)1.75215923
134Abnormality of methionine metabolism (HP:0010901)1.74687162
135Intestinal atresia (HP:0011100)1.74427223
136Horseshoe kidney (HP:0000085)1.74379405
137Sparse eyelashes (HP:0000653)1.73112444
138CNS demyelination (HP:0007305)1.72444829
139Progressive muscle weakness (HP:0003323)1.72239323
140Posterior subcapsular cataract (HP:0007787)1.72170923
141Hypoplasia of the pons (HP:0012110)1.72116122
142Medial flaring of the eyebrow (HP:0010747)1.71514368
143Cerebral hypomyelination (HP:0006808)1.70868685
144Hypoplasia of the radius (HP:0002984)1.70706602
145Multiple enchondromatosis (HP:0005701)1.70541696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.70783728
2VRK23.97027580
3WEE13.54743265
4BUB13.33744965
5VRK13.06501062
6TRIM282.87816873
7IRAK42.79462271
8MST42.70074192
9MAP3K122.66400300
10WNK32.61846601
11NUAK12.56529757
12BRSK22.48419378
13SRPK12.47264520
14MKNK22.43322874
15CCNB12.38254369
16ACVR1B2.34435413
17NME22.24766014
18EIF2AK32.24742782
19EIF2AK12.20273625
20MAP4K22.17731932
21MKNK12.15885842
22PLK42.14746176
23CDC72.13370484
24DYRK31.85529436
25PBK1.75248454
26BMPR1B1.67679468
27CDK81.67042215
28TSSK61.66323005
29CASK1.64799532
30PLK11.61507188
31FRK1.57337388
32MUSK1.43049649
33PLK31.42640153
34TAF11.39822098
35BRAF1.38876898
36IRAK31.38716399
37BRSK11.30479575
38NEK11.30017333
39EIF2AK21.29418275
40PASK1.29144148
41CSNK1G31.28508385
42AURKB1.27840298
43PIM21.23314239
44CSNK1G11.22239502
45TGFBR11.22007358
46SIK31.21154022
47TEC1.19506438
48ATR1.19504001
49AKT31.15269791
50NME11.13549523
51CDK71.12007166
52CHEK21.09888975
53TLK11.03990562
54CSNK1G21.03938083
55NEK21.03614998
56ARAF1.02676998
57CSNK1A1L1.02518754
58ERBB31.00669730
59OXSR11.00500722
60TTK0.99549135
61DYRK20.97063464
62BCR0.95454473
63AURKA0.91386125
64LIMK10.88108623
65MYLK0.87551916
66RPS6KA40.86937181
67TESK10.86203615
68MAP3K40.86002987
69ZAK0.84633182
70INSRR0.84174416
71YES10.83793391
72CDK190.80945446
73ILK0.79846348
74CDK30.78951241
75CSNK2A10.72921376
76STK38L0.72521891
77RPS6KB20.70479377
78PDK20.70005397
79PRKCE0.67335364
80DAPK10.66994575
81BMPR20.66177274
82RPS6KB10.64365291
83KDR0.62679506
84PIM10.61379377
85BTK0.61114888
86ABL20.60209651
87PLK20.59284439
88LATS20.59017795
89TXK0.59015741
90DAPK20.56594348
91CSNK2A20.56311386
92CHEK10.53625476
93MAPK40.53575403
94PAK10.51107208
95RPS6KA50.50980887
96WNK40.49916078
97CSNK1A10.49032075
98MAP2K70.48711777
99KIT0.48620817
100ATM0.48451506
101MAPK130.48199947
102MAP3K80.48060505
103STK240.45549277
104PRKCI0.45081063
105ADRBK10.44862739
106RPS6KL10.44088470
107RPS6KC10.44088470
108GRK70.43943673
109IRAK20.43187904
110MAPKAPK30.43109651
111MAP2K60.42508678
112CDK40.42128045
113TAOK20.41507621
114PINK10.41434665
115RPS6KA60.39980287
116TNIK0.38557667
117MOS0.37635823
118TESK20.36970695
119NEK90.34642715
120PRKCQ0.34344015
121CDK20.34291861
122BCKDK0.34271112
123IRAK10.34002084
124PAK40.33684629
125MAP3K30.32754200
126GRK10.30170004
127PRKCG0.29751486
128RAF10.29328082
129CDK10.28659740
130STK30.27512834
131ADRBK20.25458998
132MAPKAPK50.25136582
133CAMKK20.24654896
134GRK50.24438489
135TIE10.23444764
136MAP3K50.22637402
137STK390.22436985
138CAMK2A0.22152102
139FLT30.20762637
140MAP3K110.20411029

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.66285514
2DNA replication_Homo sapiens_hsa030304.40631534
3Ribosome_Homo sapiens_hsa030104.34460663
4Proteasome_Homo sapiens_hsa030503.72497410
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46164572
6Spliceosome_Homo sapiens_hsa030403.15043382
7Pyrimidine metabolism_Homo sapiens_hsa002403.14622813
8Mismatch repair_Homo sapiens_hsa034302.97787631
9Homologous recombination_Homo sapiens_hsa034402.78729055
10RNA transport_Homo sapiens_hsa030132.74039212
11Base excision repair_Homo sapiens_hsa034102.72113011
12Nucleotide excision repair_Homo sapiens_hsa034202.46544997
13Cell cycle_Homo sapiens_hsa041102.35280332
14Protein export_Homo sapiens_hsa030602.30716202
15RNA degradation_Homo sapiens_hsa030182.27329206
16Basal transcription factors_Homo sapiens_hsa030222.21166439
17Fanconi anemia pathway_Homo sapiens_hsa034602.15049526
18Purine metabolism_Homo sapiens_hsa002302.04285627
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88728420
20Non-homologous end-joining_Homo sapiens_hsa034501.68704276
21Parkinsons disease_Homo sapiens_hsa050121.64607713
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63014694
23Propanoate metabolism_Homo sapiens_hsa006401.62868174
24Oxidative phosphorylation_Homo sapiens_hsa001901.61949305
25Huntingtons disease_Homo sapiens_hsa050161.57745207
26One carbon pool by folate_Homo sapiens_hsa006701.43138375
27Vitamin B6 metabolism_Homo sapiens_hsa007501.40820411
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33916911
29Fatty acid elongation_Homo sapiens_hsa000621.30840335
30mRNA surveillance pathway_Homo sapiens_hsa030151.17818939
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17172707
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15689825
33p53 signaling pathway_Homo sapiens_hsa041151.14277811
34Cardiac muscle contraction_Homo sapiens_hsa042601.08713004
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08014050
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07774491
37Epstein-Barr virus infection_Homo sapiens_hsa051691.06012702
38Butanoate metabolism_Homo sapiens_hsa006501.02756906
39Glutathione metabolism_Homo sapiens_hsa004800.97770045
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97253387
41Steroid biosynthesis_Homo sapiens_hsa001000.96376703
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93968880
43Folate biosynthesis_Homo sapiens_hsa007900.90502971
44Pentose phosphate pathway_Homo sapiens_hsa000300.89426502
45Sulfur relay system_Homo sapiens_hsa041220.86079639
46Systemic lupus erythematosus_Homo sapiens_hsa053220.84900099
47Alzheimers disease_Homo sapiens_hsa050100.84121897
48N-Glycan biosynthesis_Homo sapiens_hsa005100.83023948
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82439453
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.82112550
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79062952
52Type I diabetes mellitus_Homo sapiens_hsa049400.78349121
53Selenocompound metabolism_Homo sapiens_hsa004500.77504403
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.76287196
55Nitrogen metabolism_Homo sapiens_hsa009100.75419511
56Linoleic acid metabolism_Homo sapiens_hsa005910.72388678
57Sulfur metabolism_Homo sapiens_hsa009200.70683423
58Tryptophan metabolism_Homo sapiens_hsa003800.68862212
59Oocyte meiosis_Homo sapiens_hsa041140.66859872
60Herpes simplex infection_Homo sapiens_hsa051680.65610312
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65374649
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64109282
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61826039
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61584418
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60688612
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60576961
67Collecting duct acid secretion_Homo sapiens_hsa049660.59634293
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57275711
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55635844
70Arachidonic acid metabolism_Homo sapiens_hsa005900.55378152
71Metabolic pathways_Homo sapiens_hsa011000.54607890
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.54434251
73Graft-versus-host disease_Homo sapiens_hsa053320.52114960
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50919681
75beta-Alanine metabolism_Homo sapiens_hsa004100.49726075
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45916737
77Ether lipid metabolism_Homo sapiens_hsa005650.45868858
78Fatty acid degradation_Homo sapiens_hsa000710.45494819
79Thyroid cancer_Homo sapiens_hsa052160.45169324
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42995587
81Phototransduction_Homo sapiens_hsa047440.41766669
82Vitamin digestion and absorption_Homo sapiens_hsa049770.40904193
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39563668
84Rheumatoid arthritis_Homo sapiens_hsa053230.39426077
85Olfactory transduction_Homo sapiens_hsa047400.38774714
86Caffeine metabolism_Homo sapiens_hsa002320.38125670
87Fatty acid metabolism_Homo sapiens_hsa012120.38096091
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37936683
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37681670
90Antigen processing and presentation_Homo sapiens_hsa046120.36813736
91Viral carcinogenesis_Homo sapiens_hsa052030.36741536
92Galactose metabolism_Homo sapiens_hsa000520.36596052
93HTLV-I infection_Homo sapiens_hsa051660.36008838
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35834178
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35113208
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31875704
97Regulation of autophagy_Homo sapiens_hsa041400.31135122
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30604826
99Sphingolipid metabolism_Homo sapiens_hsa006000.29233417
100Fructose and mannose metabolism_Homo sapiens_hsa000510.28521533
101Biosynthesis of amino acids_Homo sapiens_hsa012300.27308486
102Other glycan degradation_Homo sapiens_hsa005110.26602993
103Renin-angiotensin system_Homo sapiens_hsa046140.26422953
104Pyruvate metabolism_Homo sapiens_hsa006200.25076517
105Alcoholism_Homo sapiens_hsa050340.24552153
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23584202
107Allograft rejection_Homo sapiens_hsa053300.22764041
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22690155
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21965438
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.21554322
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19968803
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.19560584
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18459452
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18345657
115Measles_Homo sapiens_hsa051620.18001698
116Primary immunodeficiency_Homo sapiens_hsa053400.17608720
117Autoimmune thyroid disease_Homo sapiens_hsa053200.16635386
118Legionellosis_Homo sapiens_hsa051340.15144902
119Carbon metabolism_Homo sapiens_hsa012000.14892811
120TGF-beta signaling pathway_Homo sapiens_hsa043500.14689719
121Circadian rhythm_Homo sapiens_hsa047100.14540523
122Hematopoietic cell lineage_Homo sapiens_hsa046400.14314023
123Asthma_Homo sapiens_hsa053100.12485658
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11024256
125Peroxisome_Homo sapiens_hsa041460.09913401
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09782188
127Chemical carcinogenesis_Homo sapiens_hsa052040.09352871
128Leishmaniasis_Homo sapiens_hsa051400.07225857
129Colorectal cancer_Homo sapiens_hsa052100.07106820
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.04076784
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03824392
132Retinol metabolism_Homo sapiens_hsa008300.03245253
133Hepatitis B_Homo sapiens_hsa051610.03021275

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