TMEM217

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.99844184
2cell-cell recognition (GO:0009988)9.89828631
3spermatid development (GO:0007286)9.77863468
4axonemal dynein complex assembly (GO:0070286)9.45922847
5plasma membrane fusion (GO:0045026)9.34155583
6epithelial cilium movement (GO:0003351)9.13506925
7cilium or flagellum-dependent cell motility (GO:0001539)8.81351971
8motile cilium assembly (GO:0044458)8.79222111
9reproduction (GO:0000003)8.75510203
10piRNA metabolic process (GO:0034587)8.48840318
11negative regulation of inclusion body assembly (GO:0090084)8.11149105
12male meiosis (GO:0007140)7.79114001
13regulation of cilium movement (GO:0003352)7.71427902
14synaptonemal complex organization (GO:0070193)7.71296522
15synaptonemal complex assembly (GO:0007130)7.56784118
16cilium movement (GO:0003341)7.46037618
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.03656520
18single fertilization (GO:0007338)7.01377655
19spermatogenesis (GO:0007283)6.79775253
20male gamete generation (GO:0048232)6.76886941
21organic cation transport (GO:0015695)6.64168729
22sperm capacitation (GO:0048240)6.52327264
23gamete generation (GO:0007276)6.23690987
24regulation of inclusion body assembly (GO:0090083)6.22362726
25fertilization (GO:0009566)6.17791710
26microtubule depolymerization (GO:0007019)5.84533465
27DNA methylation involved in gamete generation (GO:0043046)5.52290845
28germ cell development (GO:0007281)5.51888737
29regulation of vitamin D biosynthetic process (GO:0060556)5.48186521
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.37898178
31chromosome condensation (GO:0030261)5.35953589
32calcium ion-dependent exocytosis (GO:0017156)5.25657639
33male meiosis I (GO:0007141)5.25422621
34DNA packaging (GO:0006323)5.10506375
35glycerol ether metabolic process (GO:0006662)5.09473002
36chromosome organization involved in meiosis (GO:0070192)5.08806029
37microtubule severing (GO:0051013)5.02542257
38positive regulation of heat generation (GO:0031652)4.98098086
39spermatid nucleus differentiation (GO:0007289)4.94520155
40multicellular organismal reproductive process (GO:0048609)4.84948543
41regulation of chronic inflammatory response (GO:0002676)4.82779381
42ventricular system development (GO:0021591)4.75115048
43cell recognition (GO:0008037)4.73915172
44regulation of microtubule-based movement (GO:0060632)4.72331822
45ether metabolic process (GO:0018904)4.69050778
46meiotic nuclear division (GO:0007126)4.63332149
47seminiferous tubule development (GO:0072520)4.62725390
48regulation of cytokine secretion involved in immune response (GO:0002739)4.56319727
49regulation of T-helper 1 cell differentiation (GO:0045625)4.49102240
50regulation of fever generation (GO:0031620)4.47311900
51sexual reproduction (GO:0019953)4.40341271
52meiotic cell cycle (GO:0051321)4.31719099
53kynurenine metabolic process (GO:0070189)4.26267465
54regulation of vitamin metabolic process (GO:0030656)4.25449726
55meiosis I (GO:0007127)4.23416957
56chaperone-mediated protein complex assembly (GO:0051131)4.21001881
57positive regulation of chemokine biosynthetic process (GO:0045080)4.11720268
58multicellular organismal development (GO:0007275)3.96493027
59sequestering of actin monomers (GO:0042989)3.90277373
60left/right pattern formation (GO:0060972)3.88672977
61indole-containing compound catabolic process (GO:0042436)3.88514287
62indolalkylamine catabolic process (GO:0046218)3.88514287
63tryptophan catabolic process (GO:0006569)3.88514287
64regulation of interferon-alpha production (GO:0032647)3.88344875
65negative regulation of interleukin-12 production (GO:0032695)3.84888906
66negative regulation of nitric oxide biosynthetic process (GO:0045019)3.82114688
67regulation of chemokine biosynthetic process (GO:0045073)3.80895507
68RNA destabilization (GO:0050779)3.79583654
69positive regulation of prostaglandin secretion (GO:0032308)3.76038371
70type I interferon signaling pathway (GO:0060337)3.74652090
71cellular response to type I interferon (GO:0071357)3.74652090
72negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.72072539
73interferon-gamma secretion (GO:0072643)3.71913192
74response to type I interferon (GO:0034340)3.69655988
75tryptophan metabolic process (GO:0006568)3.69066175
76NIK/NF-kappaB signaling (GO:0038061)3.63927324
77immunoglobulin mediated immune response (GO:0016064)3.63755982
78regulation of spindle checkpoint (GO:0090231)3.62123385
79regulation of heat generation (GO:0031650)3.61573884
80monoubiquitinated protein deubiquitination (GO:0035520)3.57455515
81genitalia morphogenesis (GO:0035112)3.51049992
82regulation of immunoglobulin secretion (GO:0051023)3.50958870
83positive regulation of defense response to virus by host (GO:0002230)3.48519610
84regulation of prostaglandin secretion (GO:0032306)3.43089377
85positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.38503053
86amino-acid betaine transport (GO:0015838)3.38001106
87carnitine transport (GO:0015879)3.38001106
88protein refolding (GO:0042026)3.36972855
89regulation of mononuclear cell migration (GO:0071675)3.30355618
90regulation of podosome assembly (GO:0071801)3.30041542
91mitotic sister chromatid cohesion (GO:0007064)3.30019386
92carnitine transmembrane transport (GO:1902603)3.28716738
93myeloid dendritic cell differentiation (GO:0043011)3.28545550
94protein polyglutamylation (GO:0018095)3.28254608
95negative regulation of lipid storage (GO:0010888)3.26760267
96branching involved in labyrinthine layer morphogenesis (GO:0060670)3.22122374
97lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17266694
98cellular response to nicotine (GO:0071316)3.17143818
99protein localization to cilium (GO:0061512)3.16209934
100T-helper 1 type immune response (GO:0042088)3.13008215
101positive regulation of NF-kappaB import into nucleus (GO:0042346)3.11906688
102nucleus organization (GO:0006997)3.11663188
103protein K11-linked deubiquitination (GO:0035871)3.11520416
104interferon-gamma-mediated signaling pathway (GO:0060333)3.10862552
105microtubule polymerization or depolymerization (GO:0031109)3.10412476
106response to peptidoglycan (GO:0032494)3.08645412
107single strand break repair (GO:0000012)3.08554795
108monocyte chemotaxis (GO:0002548)3.06562735
109purine nucleotide salvage (GO:0032261)3.05144551
110regulation of inflammatory response to antigenic stimulus (GO:0002861)3.04356959
111positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02963118
112regulation of nitric oxide biosynthetic process (GO:0045428)3.01761185
113synapsis (GO:0007129)3.00623994
114positive regulation of interferon-alpha production (GO:0032727)3.00054354
115cellular biogenic amine catabolic process (GO:0042402)2.98643638
116amine catabolic process (GO:0009310)2.98643638
117positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97920718
118response to protozoan (GO:0001562)2.95392365
119positive regulation of lymphocyte apoptotic process (GO:0070230)2.94187752
120alditol metabolic process (GO:0019400)2.92291433
121regulation of membrane protein ectodomain proteolysis (GO:0051043)2.92153347
122virion attachment to host cell (GO:0019062)2.92109908
123adhesion of symbiont to host cell (GO:0044650)2.92109908
124indolalkylamine metabolic process (GO:0006586)2.91321657
125negative regulation of cytokine production involved in immune response (GO:0002719)2.90302063
126nucleoside diphosphate phosphorylation (GO:0006165)2.89343912
127positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89297748
128glycolytic process (GO:0006096)2.89271756
129negative regulation of amino acid transport (GO:0051956)2.87388882
130meiotic cell cycle process (GO:1903046)2.86176501
131negative regulation of myeloid cell apoptotic process (GO:0033033)2.85353038
132lactate metabolic process (GO:0006089)2.85003797
133regulation of defense response to virus by host (GO:0050691)2.84683770
134B cell mediated immunity (GO:0019724)2.82978268
135regulation of interleukin-12 production (GO:0032655)2.82503025
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82417727
137cellular response to lipopolysaccharide (GO:0071222)2.81645312
138positive regulation of nitric oxide biosynthetic process (GO:0045429)2.81146312
139regulation of T-helper cell differentiation (GO:0045622)2.77638905
140positive regulation of T-helper cell differentiation (GO:0045624)2.76032136
141cellular response to exogenous dsRNA (GO:0071360)2.74809232
142myeloid dendritic cell activation (GO:0001773)2.74169677
143dendritic cell differentiation (GO:0097028)2.72710412
144regulation of cilium assembly (GO:1902017)2.72106973
145cellular response to interferon-gamma (GO:0071346)2.71722563
146defense response to protozoan (GO:0042832)2.71636945
147positive regulation of natural killer cell differentiation (GO:0032825)2.71599728
148cellular response to molecule of bacterial origin (GO:0071219)2.70190035
149positive regulation of interleukin-12 production (GO:0032735)2.68794368
150germinal center formation (GO:0002467)2.68648340
151positive regulation of interferon-beta production (GO:0032728)2.68483883
152gene silencing by RNA (GO:0031047)2.67650011
153positive regulation of interleukin-6 production (GO:0032755)2.67367936
154positive regulation of type 2 immune response (GO:0002830)2.66569262
155negative regulation of viral genome replication (GO:0045071)2.66495496
156positive regulation of macrophage activation (GO:0043032)2.66139561
157response to ATP (GO:0033198)2.65427146
158cellular response to arsenic-containing substance (GO:0071243)2.65065398
159regulation of T-helper 1 type immune response (GO:0002825)2.63302702
160purine-containing compound salvage (GO:0043101)2.62983831
161oligosaccharide catabolic process (GO:0009313)2.62925395
162microtubule-based movement (GO:0007018)2.62627421
163regulation of NF-kappaB import into nucleus (GO:0042345)2.62369807
164negative regulation of cytokine secretion (GO:0050710)2.62226949
165regulation of interleukin-8 biosynthetic process (GO:0045414)2.60064309
166polyol catabolic process (GO:0046174)2.59692781
167positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.59449256
168positive regulation of acute inflammatory response (GO:0002675)2.59403992
169T cell activation involved in immune response (GO:0002286)2.59278100
170GTP biosynthetic process (GO:0006183)2.59075617
171negative regulation of skeletal muscle tissue development (GO:0048642)2.58879986
172regulation of heterotypic cell-cell adhesion (GO:0034114)2.58695050
173RNA localization (GO:0006403)2.58263992
174response to interferon-gamma (GO:0034341)2.56751723
175membrane protein intracellular domain proteolysis (GO:0031293)2.55988287
176purine deoxyribonucleotide catabolic process (GO:0009155)2.55222807
177positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54738371
178sphingosine metabolic process (GO:0006670)2.53217987
179mature B cell differentiation involved in immune response (GO:0002313)2.51534777
180regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51286790
181glycerol metabolic process (GO:0006071)2.49310654
182intraciliary transport (GO:0042073)2.48921750
183regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.48683390
184positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.48603994
185negative regulation of organelle assembly (GO:1902116)2.42646075
186cilium morphogenesis (GO:0060271)2.42368493
187cilium organization (GO:0044782)2.37546808
188cellular component assembly involved in morphogenesis (GO:0010927)2.34566978
189polyamine biosynthetic process (GO:0006596)2.33771633
190quaternary ammonium group transport (GO:0015697)2.33365891
191axoneme assembly (GO:0035082)2.33201409
192sperm motility (GO:0030317)13.5489418
193fusion of sperm to egg plasma membrane (GO:0007342)12.4140416
194acrosome reaction (GO:0007340)11.9649018
195acrosome assembly (GO:0001675)11.7562412
196cell wall macromolecule catabolic process (GO:0016998)11.7544574
197cell wall macromolecule metabolic process (GO:0044036)11.7544574
198sperm-egg recognition (GO:0035036)11.0696068
199binding of sperm to zona pellucida (GO:0007339)10.2814862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.75325052
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.07929312
3EZH2_22144423_ChIP-Seq_EOC_Human5.13372797
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.00991993
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.68737504
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.58800108
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97993865
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.51896147
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44675780
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08748254
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.04365039
12STAT6_21828071_ChIP-Seq_BEAS2B_Human3.01950690
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92862245
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64061803
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63954104
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.60398028
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58958225
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51134573
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47870588
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45095426
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39620641
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30442432
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27562663
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27516826
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25406284
26VDR_22108803_ChIP-Seq_LS180_Human2.17048941
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14342894
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13982768
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13978410
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.11946959
31GATA1_26923725_Chip-Seq_HPCs_Mouse2.11906983
32GATA2_21666600_ChIP-Seq_HMVEC_Human2.09217863
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07939178
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05351850
35SMAD_19615063_ChIP-ChIP_OVARY_Human2.04683118
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97330246
37ZNF274_21170338_ChIP-Seq_K562_Hela1.96166887
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91185225
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90048949
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87967835
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86769691
42VDR_24787735_ChIP-Seq_THP-1_Human1.83138622
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.81653258
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.79638176
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76574807
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.75328346
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74951680
48STAT1_17558387_ChIP-Seq_HELA_Human1.73286641
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70863582
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70762937
51GATA3_26560356_Chip-Seq_TH2_Human1.69796607
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69436423
53GATA1_22025678_ChIP-Seq_K562_Human1.67611208
54* STAT1_20625510_ChIP-Seq_HELA_Human1.65726292
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64724517
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.63159817
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61775697
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60205647
59* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57518550
60SPI1_23547873_ChIP-Seq_NB4_Human1.57217068
61TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55594533
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54580042
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.54542610
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53959049
65VDR_23849224_ChIP-Seq_CD4+_Human1.53932112
66* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53311423
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51258183
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.51065094
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50709837
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50032622
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47417328
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44992778
73FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44158970
74MYB_26560356_Chip-Seq_TH2_Human1.43195073
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42030303
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.41387388
77KDM2B_26808549_Chip-Seq_REH_Human1.41141183
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40570856
79P53_21459846_ChIP-Seq_SAOS-2_Human1.35251466
80* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34676057
81TFEB_21752829_ChIP-Seq_HELA_Human1.33723078
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32659776
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.30457545
84SCL_19346495_ChIP-Seq_HPC-7_Human1.29267961
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25484148
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24787305
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.24317305
88IRF1_19129219_ChIP-ChIP_H3396_Human1.23757710
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23476649
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23096931
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.22860496
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22731245
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22461067
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20778904
95GF1_26923725_Chip-Seq_HPCs_Mouse1.18917913
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18893907
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.18523245
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17529571
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17369488
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.16425765
101* SPI1_23127762_ChIP-Seq_K562_Human1.16377895
102* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16307420
103MYB_26560356_Chip-Seq_TH1_Human1.16224830
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14657376
105RUNX_20019798_ChIP-Seq_JUKART_Human1.14076986
106CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13684116
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13379691
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13190772
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12656999
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11676612
111GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11396481
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.11109738
113REST_21632747_ChIP-Seq_MESCs_Mouse1.10693762
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10129410
115RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09790442
116* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08993449
117GATA1_19941826_ChIP-Seq_K562_Human1.08904661
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08684006
119KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08470600
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.08298025
121CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08049146
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06276900
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06012330
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05871048
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05418387
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04079349
127ERG_20517297_ChIP-Seq_VCAP_Human1.02097960
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.02044397
129SPI1_26923725_Chip-Seq_HPCs_Mouse1.01906246
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.01470732
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01391713
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01378202
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00996486
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00351583
135MAF_26560356_Chip-Seq_TH1_Human1.00115823
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99436324
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99199786
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99199786
139MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99084424
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98577451
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98182808
142CBP_20019798_ChIP-Seq_JUKART_Human0.98182808
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96428479
144P53_22387025_ChIP-Seq_ESCs_Mouse0.96026578
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95870049
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.95802568
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95666021
148SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95258741
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.94984712
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.94853203
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94729726
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94246806
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.94014491
154* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93907714
155BCOR_27268052_Chip-Seq_Bcells_Human0.93447478
156CTCF_20526341_ChIP-Seq_ESCs_Human0.93151042
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92897503
158CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92864831
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.92828725
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92727294
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92592827
162CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92589753
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92529561
164NANOG_20526341_ChIP-Seq_ESCs_Human0.91925300
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.91635264
166CTCF_26484167_Chip-Seq_Bcells_Mouse0.91440743
167EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89834090
168TAF15_26573619_Chip-Seq_HEK293_Human0.89694864
169ELF1_20517297_ChIP-Seq_JURKAT_Human0.89306117
170PU_27001747_Chip-Seq_BMDM_Mouse0.89143431
171SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88866016
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.88846360
173EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88762790
174GATA3_27048872_Chip-Seq_THYMUS_Human0.88758911
175P300_18555785_Chip-Seq_ESCs_Mouse0.88754965
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88088286
177LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88045332
178ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87985175
179* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87814174
180NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87556939
181CMYC_18555785_Chip-Seq_ESCs_Mouse0.87453539
182CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86169289
183GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83719264
184BCL6_27268052_Chip-Seq_Bcells_Human0.82779426
185FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82098840
186FOXP3_21729870_ChIP-Seq_TREG_Human0.81547984
187VDR_24763502_ChIP-Seq_THP-1_Human0.78212232
188UTX_26944678_Chip-Seq_JUKART_Human0.75594875
189YY1_21170310_ChIP-Seq_MESCs_Mouse0.74911903
190ELK1_22589737_ChIP-Seq_MCF10A_Human0.73091588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.99047467
2MP0001929_abnormal_gametogenesis5.55614599
3MP0008877_abnormal_DNA_methylation4.18753686
4MP0002210_abnormal_sex_determination3.48285685
5MP0002161_abnormal_fertility/fecundity3.22586111
6MP0009785_altered_susceptibility_to3.13193389
7MP0003724_increased_susceptibility_to2.92667981
8MP0006082_CNS_inflammation2.91907833
9MP0001145_abnormal_male_reproductive2.90756531
10MP0009764_decreased_sensitivity_to2.90087177
11MP0009840_abnormal_foam_cell2.79092406
12MP0005671_abnormal_response_to2.74865886
13MP0003436_decreased_susceptibility_to2.71284902
14MP0005000_abnormal_immune_tolerance2.60975599
15MP0001835_abnormal_antigen_presentation2.60797764
16MP0006054_spinal_hemorrhage2.51522876
17MP0002139_abnormal_hepatobiliary_system2.50377315
18MP0000653_abnormal_sex_gland2.48852133
19MP0003806_abnormal_nucleotide_metabolis2.41890971
20MP0004510_myositis2.30401061
21MP0005387_immune_system_phenotype2.24754844
22MP0001790_abnormal_immune_system2.24754844
23MP0000343_altered_response_to2.15239906
24MP0005670_abnormal_white_adipose2.11847809
25MP0002419_abnormal_innate_immunity2.04542651
26MP0002452_abnormal_antigen_presenting2.02177595
27MP0005410_abnormal_fertilization16.2722318
28MP0002723_abnormal_immune_serum1.97975778
29MP0002332_abnormal_exercise_endurance1.93922528
30MP0005167_abnormal_blood-brain_barrier1.93795655
31MP0002138_abnormal_hepatobiliary_system1.90090961
32MP0008004_abnormal_stomach_pH1.88320847
33MP0001533_abnormal_skeleton_physiology1.87880945
34MP0003656_abnormal_erythrocyte_physiolo1.86495115
35MP0001800_abnormal_humoral_immune1.85595485
36MP0003075_altered_response_to1.78332027
37MP0002653_abnormal_ependyma_morphology1.67870570
38MP0001853_heart_inflammation1.66602292
39MP0001845_abnormal_inflammatory_respons1.60648163
40MP0001819_abnormal_immune_cell1.57254409
41MP0002420_abnormal_adaptive_immunity1.55420765
42MP0003186_abnormal_redox_activity1.54010976
43MP0008875_abnormal_xenobiotic_pharmacok1.50359367
44MP0009333_abnormal_splenocyte_physiolog1.48908459
45MP0010155_abnormal_intestine_physiology1.47196841
46MP0002160_abnormal_reproductive_system1.45234702
47MP0008469_abnormal_protein_level1.45130610
48MP0000372_irregular_coat_pigmentation1.43812340
49MP0003646_muscle_fatigue1.37603310
50MP0000685_abnormal_immune_system1.27579501
51MP0002254_reproductive_system_inflammat1.27427924
52MP0005310_abnormal_salivary_gland1.27044877
53MP0001501_abnormal_sleep_pattern1.24229093
54MP0003191_abnormal_cellular_cholesterol1.19538142
55MP0001542_abnormal_bone_strength1.18434529
56MP0002796_impaired_skin_barrier1.17985957
57MP0005166_decreased_susceptibility_to1.13741390
58MP0005164_abnormal_response_to1.13736653
59MP0004147_increased_porphyrin_level1.12682975
60MP0000716_abnormal_immune_system1.11779312
61MP0003329_amyloid_beta_deposits1.09565266
62MP0001765_abnormal_ion_homeostasis1.08350728
63MP0005266_abnormal_metabolism1.08168020
64MP0002837_dystrophic_cardiac_calcinosis1.07167996
65MP0005464_abnormal_platelet_physiology1.06025695
66MP0005165_increased_susceptibility_to1.04237806
67MP0005623_abnormal_meninges_morphology1.02896246
68MP0005647_abnormal_sex_gland1.00844048
69MP0009765_abnormal_xenobiotic_induced0.99469376
70MP0000689_abnormal_spleen_morphology0.99332287
71MP0008057_abnormal_DNA_replication0.96811795
72MP0009763_increased_sensitivity_to0.96385461
73MP0003011_delayed_dark_adaptation0.94984127
74MP0002398_abnormal_bone_marrow0.94463361
75MP0005390_skeleton_phenotype0.93179885
76MP0002998_abnormal_bone_remodeling0.91510768
77MP0002429_abnormal_blood_cell0.89619454
78MP0003879_abnormal_hair_cell0.83039315
79MP0002282_abnormal_trachea_morphology0.82152880
80MP0001727_abnormal_embryo_implantation0.81200536
81MP0002722_abnormal_immune_system0.74761437
82MP0005376_homeostasis/metabolism_phenot0.72852944
83MP0000604_amyloidosis0.72134185
84MP0000920_abnormal_myelination0.70584699
85MP0002163_abnormal_gland_morphology0.70521118
86MP0000609_abnormal_liver_physiology0.68886952
87MP0009643_abnormal_urine_homeostasis0.68077113
88MP0005666_abnormal_adipose_tissue0.67874919
89MP0001851_eye_inflammation0.67431196
90MP0001663_abnormal_digestive_system0.66994142
91MP0008058_abnormal_DNA_repair0.65756174
92MP0002933_joint_inflammation0.64574875
93MP0005319_abnormal_enzyme/_coenzyme0.63310133
94MP0005636_abnormal_mineral_homeostasis0.62598763
95MP0003453_abnormal_keratinocyte_physiol0.61790084
96MP0002234_abnormal_pharynx_morphology0.61357761
97MP0008995_early_reproductive_senescence0.61030684
98MP0004883_abnormal_blood_vessel0.61015266
99MP0002136_abnormal_kidney_physiology0.60479003
100MP0004233_abnormal_muscle_weight0.60394440
101MP0008873_increased_physiological_sensi0.60059469
102MP0005389_reproductive_system_phenotype0.59343540
103MP0002090_abnormal_vision0.58818901
104MP0009046_muscle_twitch0.58815719
105MP0003941_abnormal_skin_development0.58118998
106MP0005535_abnormal_body_temperature0.57796452
107MP0005451_abnormal_body_composition0.56419347
108MP0005023_abnormal_wound_healing0.56274328
109MP0003115_abnormal_respiratory_system0.56263295
110MP0005397_hematopoietic_system_phenotyp0.56254928
111MP0001545_abnormal_hematopoietic_system0.56254928
112MP0005595_abnormal_vascular_smooth0.56055029
113MP0010094_abnormal_chromosome_stability0.55317573
114MP0000249_abnormal_blood_vessel0.54985007
115MP0004043_abnormal_pH_regulation0.54782588
116MP0003172_abnormal_lysosome_physiology0.54718017
117MP0003878_abnormal_ear_physiology0.54481800
118MP0005377_hearing/vestibular/ear_phenot0.54481800
119MP0001984_abnormal_olfaction0.54026664
120MP0005501_abnormal_skin_physiology0.52014084
121MP0001764_abnormal_homeostasis0.51924202
122MP0002295_abnormal_pulmonary_circulatio0.48410431
123MP0008007_abnormal_cellular_replicative0.47942622
124MP0003786_premature_aging0.47769345
125MP0003950_abnormal_plasma_membrane0.46582010
126MP0003699_abnormal_female_reproductive0.46276512
127MP0005253_abnormal_eye_physiology0.44927231
128MP0000647_abnormal_sebaceous_gland0.43910068
129MP0000858_altered_metastatic_potential0.42673597
130MP0002736_abnormal_nociception_after0.42357271
131MP0003300_gastrointestinal_ulcer0.40128165
132MP0004036_abnormal_muscle_relaxation0.38648355
133MP0003303_peritoneal_inflammation0.38356004
134MP0003183_abnormal_peptide_metabolism0.38166308
135MP0003195_calcinosis0.36528244
136MP0005174_abnormal_tail_pigmentation0.35795849
137MP0005375_adipose_tissue_phenotype0.35458524
138MP0002405_respiratory_system_inflammati0.34063126
139MP0004808_abnormal_hematopoietic_stem0.32940951
140MP0004270_analgesia0.31680889
141MP0000358_abnormal_cell_content/0.31438697
142MP0005058_abnormal_lysosome_morphology0.30658103
143MP0002971_abnormal_brown_adipose0.30639268
144MP0010771_integument_phenotype0.30598745
145MP0004742_abnormal_vestibular_system0.30349806
146MP0006072_abnormal_retinal_apoptosis0.29882406
147MP0010307_abnormal_tumor_latency0.29689424
148MP0001216_abnormal_epidermal_layer0.29402334
149MP0002229_neurodegeneration0.28831295
150MP0001849_ear_inflammation0.27015490
151MP0003111_abnormal_nucleus_morphology0.26201650
152MP0003633_abnormal_nervous_system0.24923119
153MP0002133_abnormal_respiratory_system0.24660915
154MP0005388_respiratory_system_phenotype0.24660915
155MP0004811_abnormal_neuron_physiology0.24361020
156MP0001346_abnormal_lacrimal_gland0.24188509
157MP0003634_abnormal_glial_cell0.24133922
158MP0002693_abnormal_pancreas_physiology0.23713911
159MP0000383_abnormal_hair_follicle0.23100582
160MP0010678_abnormal_skin_adnexa0.22405516
161MP0002873_normal_phenotype0.21654697
162MP0002169_no_abnormal_phenotype0.21622071
163MP0005391_vision/eye_phenotype0.21584083
164MP0003448_altered_tumor_morphology0.21303218
165MP0004947_skin_inflammation0.21184660
166MP0009278_abnormal_bone_marrow0.21045592
167MP0005551_abnormal_eye_electrophysiolog0.20702364
168MP0003631_nervous_system_phenotype0.20255305
169MP0003948_abnormal_gas_homeostasis0.19696963
170MP0006036_abnormal_mitochondrial_physio0.18837022
171MP0002118_abnormal_lipid_homeostasis0.18050333
172MP0005025_abnormal_response_to0.17984213
173MP0003632_abnormal_nervous_system0.17550227
174MP0002060_abnormal_skin_morphology0.17209980
175MP0002148_abnormal_hypersensitivity_rea0.17188956
176MP0001730_embryonic_growth_arrest0.17094103

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.33601321
2Abnormal respiratory epithelium morphology (HP:0012253)8.90350286
3Abnormal respiratory motile cilium morphology (HP:0005938)8.90350286
4Rhinitis (HP:0012384)7.54305979
5Chronic bronchitis (HP:0004469)7.47186933
6Abnormal ciliary motility (HP:0012262)7.21712400
7Infertility (HP:0000789)7.07958410
8Nasal polyposis (HP:0100582)6.67492802
9Vacuolated lymphocytes (HP:0001922)5.91014321
10Abnormality of glycolipid metabolism (HP:0010969)5.80589284
11Abnormality of liposaccharide metabolism (HP:0010968)5.80589284
12Abnormality of glycosphingolipid metabolism (HP:0004343)5.80589284
13Abnormality of the nasal mucosa (HP:0000433)5.39620207
14Stomatitis (HP:0010280)5.19827904
15Bronchitis (HP:0012387)4.62527491
16Bronchiectasis (HP:0002110)4.56063466
17Male infertility (HP:0003251)4.13379676
18Increased cerebral lipofuscin (HP:0011813)3.97854202
19Retrobulbar optic neuritis (HP:0100654)3.71017348
20Optic neuritis (HP:0100653)3.71017348
21Autoimmune thrombocytopenia (HP:0001973)3.67868059
22Abnormal spermatogenesis (HP:0008669)3.62847297
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.59213748
24Parakeratosis (HP:0001036)3.56383818
25Nephronophthisis (HP:0000090)3.46865791
26Nausea (HP:0002018)3.45820487
27Dysostosis multiplex (HP:0000943)3.43855477
28Orchitis (HP:0100796)3.35333256
29Recurrent otitis media (HP:0000403)3.27981911
30Recurrent sinusitis (HP:0011108)3.15085222
31Mutism (HP:0002300)3.02875927
32Gonadotropin excess (HP:0000837)2.97450852
33Pulmonary infiltrates (HP:0002113)2.94631832
34Prostate neoplasm (HP:0100787)2.91520174
35Neurofibrillary tangles (HP:0002185)2.84034050
36Generalized aminoaciduria (HP:0002909)2.82653721
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82558142
38Abnormality of polysaccharide metabolism (HP:0011012)2.82558142
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82558142
40Hematochezia (HP:0002573)2.76985541
41Abnormality of macrophages (HP:0004311)2.76286124
42Recurrent bronchitis (HP:0002837)2.72754530
43Myositis (HP:0100614)2.68601841
44Systemic lupus erythematosus (HP:0002725)2.66936474
45Tubular atrophy (HP:0000092)2.62007494
46B lymphocytopenia (HP:0010976)2.52893509
47Abnormality of B cell number (HP:0010975)2.52693411
48Gangrene (HP:0100758)2.52089862
49Abnormality of the renal medulla (HP:0100957)2.51230578
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.50345796
51Hypertensive crisis (HP:0100735)2.50310232
52Metaphyseal irregularity (HP:0003025)2.49688744
53Urinary glycosaminoglycan excretion (HP:0003541)2.46378103
54Mucopolysacchariduria (HP:0008155)2.46378103
55Increased serum ferritin (HP:0003281)2.43826188
56Azoospermia (HP:0000027)2.41518128
57Increased IgM level (HP:0003496)2.41215219
58Mediastinal lymphadenopathy (HP:0100721)2.39174078
59Poor head control (HP:0002421)2.35134946
60Combined immunodeficiency (HP:0005387)2.34896899
61Impulsivity (HP:0100710)2.33480412
62Keratoconjunctivitis sicca (HP:0001097)2.32111975
63Keratoconjunctivitis (HP:0001096)2.31510361
64Spastic tetraparesis (HP:0001285)2.30929588
65Abnormality of transition element cation homeostasis (HP:0011030)2.30232696
66Autoimmune hemolytic anemia (HP:0001890)2.29077793
67Progressive neurologic deterioration (HP:0002344)2.28765315
68Abnormality of iron homeostasis (HP:0011031)2.25232254
69Severe combined immunodeficiency (HP:0004430)2.24610899
70Elevated erythrocyte sedimentation rate (HP:0003565)2.21302744
71Abnormality of midbrain morphology (HP:0002418)2.20725729
72Molar tooth sign on MRI (HP:0002419)2.20725729
73Abnormality of the prostate (HP:0008775)2.19921973
74Tubulointerstitial abnormality (HP:0001969)2.17847254
75Ectropion (HP:0000656)2.16733944
76Tubulointerstitial nephritis (HP:0001970)2.16689607
77Cholecystitis (HP:0001082)2.15622490
78Abnormal gallbladder physiology (HP:0012438)2.15622490
79Amyotrophic lateral sclerosis (HP:0007354)2.15096099
80Cerebral inclusion bodies (HP:0100314)2.14122862
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12869223
82Hemoptysis (HP:0002105)2.12015792
83Hepatosplenomegaly (HP:0001433)2.11859551
84Severe visual impairment (HP:0001141)2.11411977
85Vasculitis (HP:0002633)2.05185286
86Petechiae (HP:0000967)2.05003254
87Dyschromatopsia (HP:0007641)2.03426591
88Intrahepatic cholestasis (HP:0001406)2.02551087
89Abnormality of the lower motor neuron (HP:0002366)2.02274224
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00870638
91Dynein arm defect of respiratory motile cilia (HP:0012255)13.1173981
92Absent/shortened dynein arms (HP:0200106)13.1173981
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9186974
94Mesangial abnormality (HP:0001966)1.99860178
95Tubulointerstitial fibrosis (HP:0005576)1.98797545
96Polyneuropathy (HP:0001271)1.97489221
97Concave nail (HP:0001598)1.96637689
98Abolished electroretinogram (ERG) (HP:0000550)1.93604245
99Anorexia (HP:0002039)1.91461728
100Abnormal protein glycosylation (HP:0012346)1.91175605
101Abnormal glycosylation (HP:0012345)1.91175605
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91175605
103Abnormal protein N-linked glycosylation (HP:0012347)1.91175605
104Nuclear cataract (HP:0100018)1.91155545
105IgG deficiency (HP:0004315)1.90646058
106Tetraparesis (HP:0002273)1.90618985
107Reduced antithrombin III activity (HP:0001976)1.90106131
108Beaking of vertebral bodies (HP:0004568)1.88455953
109Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87831264
110Joint swelling (HP:0001386)1.87731180
111Prolonged neonatal jaundice (HP:0006579)1.87666750
112Pancreatic fibrosis (HP:0100732)1.87284510
113Hepatic necrosis (HP:0002605)1.86936463
114Abnormality of the pericardium (HP:0001697)1.84754514
115Keratitis (HP:0000491)1.84593746
116Polydipsia (HP:0001959)1.83702206
117Abnormal drinking behavior (HP:0030082)1.83702206
118IgA deficiency (HP:0002720)1.82931028
119Abnormality of the basal ganglia (HP:0002134)1.82309834
120Mitochondrial inheritance (HP:0001427)1.79265490
121Porencephaly (HP:0002132)1.79116301
122Erythroderma (HP:0001019)1.78491643
123Medial flaring of the eyebrow (HP:0010747)1.77608171
124Hepatocellular necrosis (HP:0001404)1.76826583
125Abnormality of lateral ventricle (HP:0030047)1.76442121
126Recurrent bacterial skin infections (HP:0005406)1.76412084
127Abnormality of dental color (HP:0011073)1.76371121
128Choroideremia (HP:0001139)1.74339772
129Pulmonary fibrosis (HP:0002206)1.73961393
130Increased CSF lactate (HP:0002490)1.72634465
131Abnormal biliary tract physiology (HP:0012439)1.72236759
132Bile duct proliferation (HP:0001408)1.72236759
133Pancreatic cysts (HP:0001737)1.71199066
134Episodic fever (HP:0001954)1.71098708
135Loss of speech (HP:0002371)1.68451747
136Double outlet right ventricle (HP:0001719)1.66221440
137Congenital malformation of the right heart (HP:0011723)1.66221440
138Difficulty walking (HP:0002355)1.63397081
139Exercise-induced myalgia (HP:0003738)1.63051143
140Absent epiphyses (HP:0010577)1.56951378
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56951378
142Abnormality of renal excretion (HP:0011036)1.50795749
143Decreased central vision (HP:0007663)1.49937575
144Cleft eyelid (HP:0000625)1.49835103
145Delayed epiphyseal ossification (HP:0002663)1.49705091
146Easy fatigability (HP:0003388)1.47680292
147Fibular hypoplasia (HP:0003038)1.47135787
148Hemorrhage of the eye (HP:0011885)1.46403624
149Chronic sinusitis (HP:0011109)1.43608093
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.42950665
151Impaired proprioception (HP:0010831)1.39237742
152J-shaped sella turcica (HP:0002680)1.37338744
153Facial cleft (HP:0002006)1.36492787
154Oculomotor apraxia (HP:0000657)1.36425521
155Neuronal loss in central nervous system (HP:0002529)1.34662541
156Postaxial foot polydactyly (HP:0001830)1.34475106
157Widely patent fontanelles and sutures (HP:0004492)1.34410427
158Stage 5 chronic kidney disease (HP:0003774)1.33849298
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.33447488
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.33447488
161Abnormal urine output (HP:0012590)1.30484911
162Heterotopia (HP:0002282)1.27780096
163Global brain atrophy (HP:0002283)1.27383427
164Thin bony cortex (HP:0002753)1.26734570
165Congenital hepatic fibrosis (HP:0002612)1.26594070
166Exercise-induced muscle cramps (HP:0003710)1.26294246
167Personality changes (HP:0000751)1.24628134
168Abnormality of vision evoked potentials (HP:0000649)1.24522927
169Upper motor neuron abnormality (HP:0002127)1.24175820
170Abnormality of the renal cortex (HP:0011035)1.22589785
171Rhabdomyolysis (HP:0003201)1.22364275
172Retinal dysplasia (HP:0007973)1.18854036
173Decreased motor nerve conduction velocity (HP:0003431)1.18561641
174Myoglobinuria (HP:0002913)1.18547328
175Constricted visual fields (HP:0001133)1.18534222
176Absent frontal sinuses (HP:0002688)1.18450900
177Abnormality of the dental root (HP:0006486)1.17677505
178Taurodontia (HP:0000679)1.17677505
179Abnormality of permanent molar morphology (HP:0011071)1.17677505
180Renal dysplasia (HP:0000110)1.16088047
181Cerebellar dysplasia (HP:0007033)1.16010665
182Deformed sella turcica (HP:0002681)1.13476029
183Aplasia/Hypoplasia affecting the retina (HP:0008061)1.13144104
184Absent eyebrow (HP:0002223)1.12973890
185Polyuria (HP:0000103)1.12934831
186Disinhibition (HP:0000734)1.12873065
187Degeneration of anterior horn cells (HP:0002398)1.12469157
188Abnormality of the anterior horn cell (HP:0006802)1.12469157
189Bulbar palsy (HP:0001283)1.11987253
190Supranuclear gaze palsy (HP:0000605)1.11475777
191Aplasia/Hypoplasia of the lens (HP:0008063)1.09601541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.77820683
2PDK37.77820683
3TESK16.12830067
4PDK24.87421739
5IRAK34.79116193
6PRKD34.43648875
7ICK3.73157367
8MAP3K143.50832896
9NME23.31801049
10GRK73.29955752
11STK392.94638640
12IKBKB2.91498631
13TBK12.69971537
14TAOK22.59068602
15ADRBK22.58905029
16WNK42.51640049
17MATK2.42209466
18BMPR22.36637053
19MAP3K112.35468336
20PTK2B2.27474601
21TXK2.17319891
22DDR22.04969239
23ZAK1.95504847
24IKBKE1.87455947
25NUAK11.80642946
26BCKDK1.79240871
27MAP4K11.78374762
28TAOK31.77774568
29TLK11.77351448
30TGFBR21.70301068
31KDR1.68005699
32MAPKAPK51.66247566
33NEK21.56331029
34CHUK1.54817532
35JAK31.53778710
36VRK21.50038669
37TYK21.46621695
38TIE11.44734101
39KIT1.44462632
40ABL21.43920383
41PNCK1.39512166
42MAPK151.38994293
43MST41.27287173
44DYRK1B1.24435361
45ACVR1B1.23645587
46PDK11.18937359
47PASK1.18636783
48RIPK41.15876573
49STK381.13598951
50TAOK11.12762637
51BRSK21.11980869
52IRAK41.04408808
53EPHB11.03621976
54LIMK11.01207105
55DAPK31.01015387
56SYK1.00433867
57MAP4K21.00188656
58CLK10.98050900
59STK100.95123059
60WNK10.93369111
61IRAK10.92588380
62PIK3CG0.91696991
63CDC42BPA0.89725457
64MOS0.87796441
65MAP3K120.83881560
66ZAP700.83803548
67LYN0.82096042
68CSK0.81029014
69GRK10.80603771
70TEC0.76043759
71MAP3K90.76023486
72PIM10.75481446
73PDPK10.71825892
74DYRK30.71477875
75CAMKK20.70572742
76BLK0.70307497
77JAK10.67765407
78MAP2K30.61779635
79CAMKK10.59865578
80LCK0.58991231
81ARAF0.57952961
82EEF2K0.55577786
83CCNB10.55419036
84EIF2AK10.55278793
85STK30.54433386
86TTK0.54286883
87NTRK20.51192908
88GRK50.50783023
89PTK60.50180218
90MET0.49526559
91RIPK10.49289509
92EIF2AK20.49016947
93NME10.48627840
94PRKCQ0.45322753
95BRAF0.44666195
96STK240.42153728
97PBK0.41206542
98CAMK1G0.40585981
99IRAK20.40501836
100CHEK20.40232941
101TYRO30.39535657
102MUSK0.37399899
103BRSK10.34983325
104CSF1R0.33878792
105CHEK10.32963853
106INSR0.31144209
107ITK0.29101056
108FRK0.29056663
109EPHA30.27869838
110PRKCD0.27806056
111ABL10.26736688
112MAPK110.26628890
113HCK0.25758518
114VRK10.25695699
115ATR0.25546643
116MAP3K30.25420954
117MARK30.24993679
118EIF2AK30.24775654
119EGFR0.24105243
120MAPK130.23704678
121PIM20.23343356
122CDC70.23173954
123BMX0.22962406
124MAP3K100.22682209
125ROCK10.21793702
126PINK10.21017741
127LRRK20.20943569
128ATM0.20920392
129ADRBK10.20835381
130PAK10.20642771
131AKT30.20266596
132NTRK10.20266540
133DYRK20.19681834
134FLT30.19116337
135CDK150.18531638
136TESK20.18497059
137MAP3K20.18495106
138TGFBR10.17231289
139MAPKAPK20.17169405
140JAK20.16168688
141NEK90.16136890
142MAP3K10.15546278
143CDK120.15423963
144MAP2K60.14985656
145PTK20.14268274
146CDK180.13946910
147CDK11A0.13789428
148WEE10.13610654
149CDK140.13398341
150MAP3K50.12284365
151FER0.10650779
152MAPKAPK30.10557813
153PRKCG0.09997063
154ERBB30.08776920
155OXSR10.08689348
156RPS6KA50.08529457
157TRPM70.08522502
158MAP3K80.08460603
159FGR0.08437699
160SCYL20.08307283
161BTK0.08043389
162BMPR1B0.07833286
163PKN10.07555716
164STK160.07264589
165PRKACG0.07057603
166PAK20.06775661
167TNK20.06771858
168STK110.05247212
169PRKAA10.04629652
170CAMK2A0.04314519
171PRKG10.04011419
172RPS6KA10.03260102

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.52479332
2Vitamin B6 metabolism_Homo sapiens_hsa007504.23082132
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.20628659
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.78651166
5Linoleic acid metabolism_Homo sapiens_hsa005913.70624920
6Asthma_Homo sapiens_hsa053103.43383078
7Pyruvate metabolism_Homo sapiens_hsa006203.36576616
8Allograft rejection_Homo sapiens_hsa053303.06158014
9Propanoate metabolism_Homo sapiens_hsa006403.00413770
10Rheumatoid arthritis_Homo sapiens_hsa053232.98564793
11Sulfur relay system_Homo sapiens_hsa041222.80678013
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.75173886
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.67922757
14Graft-versus-host disease_Homo sapiens_hsa053322.54092090
15Glucagon signaling pathway_Homo sapiens_hsa049222.46344323
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41527064
17Autoimmune thyroid disease_Homo sapiens_hsa053202.35088333
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32356298
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26902914
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24682460
21Ether lipid metabolism_Homo sapiens_hsa005652.21458813
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21149739
23NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11400560
24Lysosome_Homo sapiens_hsa041422.07538681
25Carbohydrate digestion and absorption_Homo sapiens_hsa049732.07101270
26Leishmaniasis_Homo sapiens_hsa051402.06308068
27Malaria_Homo sapiens_hsa051442.05051663
28Steroid biosynthesis_Homo sapiens_hsa001002.04828148
29Dorso-ventral axis formation_Homo sapiens_hsa043202.00906303
30Type I diabetes mellitus_Homo sapiens_hsa049402.00177863
31TNF signaling pathway_Homo sapiens_hsa046681.98576036
32Basal transcription factors_Homo sapiens_hsa030221.98201811
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89593716
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80062519
35African trypanosomiasis_Homo sapiens_hsa051431.79961132
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.79455328
37Staphylococcus aureus infection_Homo sapiens_hsa051501.77393968
38Pentose phosphate pathway_Homo sapiens_hsa000301.74116677
39Glycerolipid metabolism_Homo sapiens_hsa005611.73535043
40Selenocompound metabolism_Homo sapiens_hsa004501.67420263
41Pertussis_Homo sapiens_hsa051331.66322196
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63657929
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63394576
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.63070165
45Hematopoietic cell lineage_Homo sapiens_hsa046401.62298905
46Fatty acid metabolism_Homo sapiens_hsa012121.57010021
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56822030
48Primary immunodeficiency_Homo sapiens_hsa053401.56699014
49Amphetamine addiction_Homo sapiens_hsa050311.56603780
50Tryptophan metabolism_Homo sapiens_hsa003801.54238739
51PPAR signaling pathway_Homo sapiens_hsa033201.52142509
52Fat digestion and absorption_Homo sapiens_hsa049751.50799109
53Caffeine metabolism_Homo sapiens_hsa002321.49144043
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48014449
55Oocyte meiosis_Homo sapiens_hsa041141.43588935
56Tuberculosis_Homo sapiens_hsa051521.41027906
57Herpes simplex infection_Homo sapiens_hsa051681.34776589
58Fanconi anemia pathway_Homo sapiens_hsa034601.34070431
59Influenza A_Homo sapiens_hsa051641.33377398
60Fatty acid degradation_Homo sapiens_hsa000711.31099670
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30648139
62Chemical carcinogenesis_Homo sapiens_hsa052041.28628966
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25103092
64Fructose and mannose metabolism_Homo sapiens_hsa000511.22856991
65Toxoplasmosis_Homo sapiens_hsa051451.22773170
66Oxidative phosphorylation_Homo sapiens_hsa001901.20189583
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.19356788
68Sulfur metabolism_Homo sapiens_hsa009201.19236128
69Arachidonic acid metabolism_Homo sapiens_hsa005901.14724051
70Measles_Homo sapiens_hsa051621.14190333
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13584892
72Carbon metabolism_Homo sapiens_hsa012001.11369194
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.10331857
74Histidine metabolism_Homo sapiens_hsa003401.06001237
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05573638
76Antigen processing and presentation_Homo sapiens_hsa046121.05417936
77Mineral absorption_Homo sapiens_hsa049781.04650332
78Sphingolipid metabolism_Homo sapiens_hsa006001.04296432
79Cysteine and methionine metabolism_Homo sapiens_hsa002701.02609451
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99601150
81Glutathione metabolism_Homo sapiens_hsa004800.97857027
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.93118731
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91442618
84Phenylalanine metabolism_Homo sapiens_hsa003600.90558922
85Collecting duct acid secretion_Homo sapiens_hsa049660.90024196
86Viral myocarditis_Homo sapiens_hsa054160.89991435
87Cardiac muscle contraction_Homo sapiens_hsa042600.89168475
88Renin secretion_Homo sapiens_hsa049240.86720391
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86498585
90Long-term potentiation_Homo sapiens_hsa047200.85512922
91Shigellosis_Homo sapiens_hsa051310.85116283
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78558586
93Fatty acid elongation_Homo sapiens_hsa000620.77973287
94Hedgehog signaling pathway_Homo sapiens_hsa043400.76820794
95Hepatitis C_Homo sapiens_hsa051600.74998049
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74880573
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74775480
98Huntingtons disease_Homo sapiens_hsa050160.74572733
99Epstein-Barr virus infection_Homo sapiens_hsa051690.74040632
100VEGF signaling pathway_Homo sapiens_hsa043700.73873300
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70750458
102RNA polymerase_Homo sapiens_hsa030200.70358727
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66630407
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64885731
105Parkinsons disease_Homo sapiens_hsa050120.61362542
106Purine metabolism_Homo sapiens_hsa002300.58845020
107Hepatitis B_Homo sapiens_hsa051610.58700058
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58169692
109Renin-angiotensin system_Homo sapiens_hsa046140.55938701
110Estrogen signaling pathway_Homo sapiens_hsa049150.54644256
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54028700
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52183825
113Insulin secretion_Homo sapiens_hsa049110.52132230
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51830720
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50347579
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49285301
117Protein export_Homo sapiens_hsa030600.47715728
118Bladder cancer_Homo sapiens_hsa052190.47519583
119Thyroid hormone synthesis_Homo sapiens_hsa049180.45923437
120Apoptosis_Homo sapiens_hsa042100.45145282
121ABC transporters_Homo sapiens_hsa020100.44607652
122Metabolic pathways_Homo sapiens_hsa011000.43544833
123Biosynthesis of amino acids_Homo sapiens_hsa012300.40740520
124Systemic lupus erythematosus_Homo sapiens_hsa053220.40502172
125Complement and coagulation cascades_Homo sapiens_hsa046100.40313026
126Pancreatic secretion_Homo sapiens_hsa049720.39056268
127Endocytosis_Homo sapiens_hsa041440.38163769
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38041578
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36980157
130B cell receptor signaling pathway_Homo sapiens_hsa046620.36147841
131Legionellosis_Homo sapiens_hsa051340.35269528
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35084791
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34163242
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.33592230
135Chemokine signaling pathway_Homo sapiens_hsa040620.33563333
136T cell receptor signaling pathway_Homo sapiens_hsa046600.33343542
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32950470
138Salmonella infection_Homo sapiens_hsa051320.32121583
139Butanoate metabolism_Homo sapiens_hsa006500.31246942
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30924293
141N-Glycan biosynthesis_Homo sapiens_hsa005100.30645923
142Alzheimers disease_Homo sapiens_hsa050100.30090152
143Retinol metabolism_Homo sapiens_hsa008300.29593686
144AMPK signaling pathway_Homo sapiens_hsa041520.29525911
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.29363362
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.27877745
147Proteasome_Homo sapiens_hsa030500.27367579
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27296149
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27270072
150Tyrosine metabolism_Homo sapiens_hsa003500.26715139
151Alcoholism_Homo sapiens_hsa050340.25175895
152Cocaine addiction_Homo sapiens_hsa050300.25114273
153p53 signaling pathway_Homo sapiens_hsa041150.25092780
154Phagosome_Homo sapiens_hsa041450.24103929
155Amoebiasis_Homo sapiens_hsa051460.23911657
156RNA transport_Homo sapiens_hsa030130.23663759
157Folate biosynthesis_Homo sapiens_hsa007900.23095462
158Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23092866
159Peroxisome_Homo sapiens_hsa041460.21545424
160HTLV-I infection_Homo sapiens_hsa051660.21500805
161AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20660257
162mRNA surveillance pathway_Homo sapiens_hsa030150.19528534
163Synaptic vesicle cycle_Homo sapiens_hsa047210.17739383
164Pyrimidine metabolism_Homo sapiens_hsa002400.14814676
165Osteoclast differentiation_Homo sapiens_hsa043800.12251613
166Inositol phosphate metabolism_Homo sapiens_hsa005620.12168509
167Calcium signaling pathway_Homo sapiens_hsa040200.11730135
168Other glycan degradation_Homo sapiens_hsa005110.10675540
169Bile secretion_Homo sapiens_hsa049760.10561001
170Maturity onset diabetes of the young_Homo sapiens_hsa049500.08905375
171Viral carcinogenesis_Homo sapiens_hsa052030.08477354
172Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08289570
173Non-homologous end-joining_Homo sapiens_hsa034500.08154610

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »