TMEM219

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.86514025
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73884963
3respiratory burst (GO:0045730)4.02277466
4response to peptidoglycan (GO:0032494)3.90988820
5protein neddylation (GO:0045116)3.87443329
6positive regulation of interferon-alpha production (GO:0032727)3.77993779
7signal peptide processing (GO:0006465)3.72263440
8hydrogen peroxide biosynthetic process (GO:0050665)3.64219341
9xenobiotic catabolic process (GO:0042178)3.60559065
10positive regulation by symbiont of host defense response (GO:0052509)3.60068401
11modulation by symbiont of host defense response (GO:0052031)3.60068401
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60068401
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60068401
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.60068401
15modulation by symbiont of host immune response (GO:0052553)3.60068401
16regulation of interferon-alpha production (GO:0032647)3.57196662
17response to interferon-beta (GO:0035456)3.55457126
18cellular response to interferon-beta (GO:0035458)3.48367667
19reactive oxygen species biosynthetic process (GO:1903409)3.44977174
20T-helper 1 type immune response (GO:0042088)3.44877469
21type I interferon signaling pathway (GO:0060337)3.40847053
22cellular response to type I interferon (GO:0071357)3.40847053
23response to type I interferon (GO:0034340)3.36334002
24aldehyde catabolic process (GO:0046185)3.34979964
25granulocyte activation (GO:0036230)3.30251819
26eosinophil chemotaxis (GO:0048245)3.26982425
27neutrophil activation (GO:0042119)3.22479292
28regulation of interferon-beta biosynthetic process (GO:0045357)3.14707429
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.08600835
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06532464
31platelet dense granule organization (GO:0060155)3.05722105
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04746362
33protein maturation by protein folding (GO:0022417)3.04715824
34superoxide anion generation (GO:0042554)3.03448992
35regulation of activation of Janus kinase activity (GO:0010533)3.02708046
36negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.01715812
37negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.00626572
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00169842
39negative regulation of myeloid cell apoptotic process (GO:0033033)2.96404973
40immunoglobulin mediated immune response (GO:0016064)2.96073577
41peptide catabolic process (GO:0043171)2.94560726
42positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.94287011
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94199718
44lipoxygenase pathway (GO:0019372)2.94027677
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93263145
46eosinophil migration (GO:0072677)2.92976919
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90412574
48defense response to protozoan (GO:0042832)2.89277778
49autophagic vacuole fusion (GO:0000046)2.88607511
50glycosphingolipid catabolic process (GO:0046479)2.87414832
51low-density lipoprotein particle remodeling (GO:0034374)2.87114072
52cyclooxygenase pathway (GO:0019371)2.86571176
53glutathione metabolic process (GO:0006749)2.84589776
54production of molecular mediator involved in inflammatory response (GO:0002532)2.84197648
55phagosome maturation (GO:0090382)2.84094458
56L-phenylalanine catabolic process (GO:0006559)2.83496940
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.83496940
58macrophage activation involved in immune response (GO:0002281)2.82882309
59hydrogen peroxide catabolic process (GO:0042744)2.81425463
60positive regulation of antigen processing and presentation (GO:0002579)2.81046909
61regulation of RIG-I signaling pathway (GO:0039535)2.80551559
62cellular response to exogenous dsRNA (GO:0071360)2.79624830
63mitochondrial calcium ion transport (GO:0006851)2.75636979
64glutathione derivative biosynthetic process (GO:1901687)2.74730361
65glutathione derivative metabolic process (GO:1901685)2.74730361
66negative regulation of viral genome replication (GO:0045071)2.72363730
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70919939
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70919939
69regulation of T-helper 1 cell differentiation (GO:0045625)2.69982951
70respiratory electron transport chain (GO:0022904)2.69287131
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68885216
72positive regulation of cellular amide metabolic process (GO:0034250)2.68463324
73myeloid cell activation involved in immune response (GO:0002275)2.68327483
74L-ascorbic acid metabolic process (GO:0019852)2.68185319
75aromatic amino acid family catabolic process (GO:0009074)2.68046253
76positive regulation of interferon-beta production (GO:0032728)2.68012186
77amino sugar catabolic process (GO:0046348)2.67926827
78electron transport chain (GO:0022900)2.67589074
79antigen processing and presentation of endogenous antigen (GO:0019883)2.67065981
80microglial cell activation (GO:0001774)2.65647999
81glycolipid catabolic process (GO:0019377)2.63607644
82regulation of chemokine biosynthetic process (GO:0045073)2.63544380
83positive regulation of monocyte chemotaxis (GO:0090026)2.60918328
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.60280213
85GDP-mannose metabolic process (GO:0019673)2.59566024
86L-phenylalanine metabolic process (GO:0006558)2.59464955
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59464955
88response to interferon-alpha (GO:0035455)2.58666858
89natural killer cell mediated immunity (GO:0002228)2.58027311
90natural killer cell mediated cytotoxicity (GO:0042267)2.58027311
91response to protozoan (GO:0001562)2.56842692
92hydrogen peroxide metabolic process (GO:0042743)2.56431294
93positive regulation of natural killer cell differentiation (GO:0032825)2.56074331
94amyloid precursor protein catabolic process (GO:0042987)2.55336355
95leukocyte mediated cytotoxicity (GO:0001909)2.55078934
96regulation of integrin-mediated signaling pathway (GO:2001044)2.53959616
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53854392
98regulation of antigen processing and presentation (GO:0002577)2.52921894
99detection of molecule of bacterial origin (GO:0032490)2.52854926
100NAD biosynthetic process (GO:0009435)2.52424835
101ATP hydrolysis coupled proton transport (GO:0015991)2.52136211
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52136211
103angiotensin maturation (GO:0002003)2.51618892
104glucuronate metabolic process (GO:0019585)2.51372734
105uronic acid metabolic process (GO:0006063)2.51372734
106protein complex biogenesis (GO:0070271)2.51328410
107viral protein processing (GO:0019082)2.50005706
108indole-containing compound catabolic process (GO:0042436)2.49565329
109indolalkylamine catabolic process (GO:0046218)2.49565329
110tryptophan catabolic process (GO:0006569)2.49565329
111ceramide catabolic process (GO:0046514)2.48348362
112ATP synthesis coupled proton transport (GO:0015986)2.48069960
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48069960
114positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.47766429
115regulation of cholesterol esterification (GO:0010872)2.47282235
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.46957515
117cellular response to zinc ion (GO:0071294)2.46582189
118thrombin receptor signaling pathway (GO:0070493)2.45940483
119positive regulation of lymphocyte migration (GO:2000403)2.45118069
120cofactor catabolic process (GO:0051187)2.44527626
121extracellular fibril organization (GO:0043206)2.44301174
122positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.44292017
123response to host immune response (GO:0052572)2.44252005
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.44252005
125negative regulation of interleukin-17 production (GO:0032700)2.44005655
126Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43601160
127positive regulation of mast cell activation (GO:0033005)2.43287932
128macrophage activation (GO:0042116)2.43257485
129positive regulation of interleukin-17 production (GO:0032740)2.42341584
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.42217549
131positive regulation of mast cell degranulation (GO:0043306)2.42217549
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41610682
133deoxyribonucleotide catabolic process (GO:0009264)2.41154658
134tryptophan metabolic process (GO:0006568)2.38577054
135myeloid dendritic cell activation (GO:0001773)2.38283095
136nonribosomal peptide biosynthetic process (GO:0019184)2.38162792
137negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.38087189
138glutathione biosynthetic process (GO:0006750)2.37633777
139regulation of interleukin-17 production (GO:0032660)2.37633483
140barbed-end actin filament capping (GO:0051016)2.37334947
141oligosaccharide catabolic process (GO:0009313)2.36875047
142positive regulation of chemokine biosynthetic process (GO:0045080)2.36660688
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.36221821
144high-density lipoprotein particle remodeling (GO:0034375)2.35667155
145positive regulation of lipoprotein lipase activity (GO:0051006)2.35436811
146positive regulation of triglyceride lipase activity (GO:0061365)2.35436811
147neutrophil mediated immunity (GO:0002446)2.34978166
148myeloid dendritic cell differentiation (GO:0043011)2.34527725
149valine metabolic process (GO:0006573)2.34006567
150mitochondrial calcium ion homeostasis (GO:0051560)2.33932559
151nucleoside diphosphate biosynthetic process (GO:0009133)2.33646782
152regulation of hypersensitivity (GO:0002883)2.33471430
153adenosine receptor signaling pathway (GO:0001973)2.33100929
154virion attachment to host cell (GO:0019062)2.33078964
155adhesion of symbiont to host cell (GO:0044650)2.33078964
156T cell migration (GO:0072678)2.33070977
157regulation of mast cell activation (GO:0033003)2.32881257
158response to muramyl dipeptide (GO:0032495)2.32830744
159regulation of vacuole organization (GO:0044088)2.30496850
160fibril organization (GO:0097435)2.30161130
161reverse cholesterol transport (GO:0043691)2.26281907
162sequestering of actin monomers (GO:0042989)2.24485888
163negative regulation of cation channel activity (GO:2001258)2.23877312
164pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.23118328
165transferrin transport (GO:0033572)2.22267475
166arachidonic acid metabolic process (GO:0019369)2.22161185
167cytochrome complex assembly (GO:0017004)2.21508555
168fat-soluble vitamin biosynthetic process (GO:0042362)2.20830599
169glycoside metabolic process (GO:0016137)2.20181198
170deoxyribose phosphate catabolic process (GO:0046386)2.20154064
171regulation of inflammatory response to antigenic stimulus (GO:0002861)2.19011996
172peptide metabolic process (GO:0006518)2.18099565
173regulation of superoxide anion generation (GO:0032928)2.16212288
174cellular response to cadmium ion (GO:0071276)2.16177001
175sphingolipid catabolic process (GO:0030149)2.15174466
176regulation of mast cell degranulation (GO:0043304)2.14394481
177positive regulation of TOR signaling (GO:0032008)2.13784638
178negative regulation of nitric oxide biosynthetic process (GO:0045019)2.13582018
179metallo-sulfur cluster assembly (GO:0031163)2.13502085
180iron-sulfur cluster assembly (GO:0016226)2.13502085
181lysosome organization (GO:0007040)2.13436050
182lytic vacuole organization (GO:0080171)2.13436050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.90735571
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.52557666
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.09855974
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.36008373
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.82253567
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74406714
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.32306555
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.31383123
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97586341
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91098049
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.85001894
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.79887319
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71774635
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62145232
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56257573
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.52980369
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46552393
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42045935
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33940305
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32241808
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29024273
22GATA1_22025678_ChIP-Seq_K562_Human2.22160607
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.21581618
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19882423
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14831400
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.14726245
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14600951
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13526704
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00987473
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96530037
31* BCL6_27268052_Chip-Seq_Bcells_Human1.87920778
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84784981
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81516617
34LXR_22292898_ChIP-Seq_THP-1_Human1.81455463
35SPI1_23547873_ChIP-Seq_NB4_Human1.80714729
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78445774
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75592609
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75500441
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75150358
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71550620
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59507184
42SCL_19346495_ChIP-Seq_HPC-7_Human1.59164714
43* BCOR_27268052_Chip-Seq_Bcells_Human1.56601625
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56257172
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.55634932
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54384627
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51372661
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50279026
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49413485
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45638880
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42963855
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40101578
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38284345
54VDR_24763502_ChIP-Seq_THP-1_Human1.36797304
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36041145
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34699318
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33457014
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33410313
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32891838
60* YY1_22570637_ChIP-Seq_MALME-3M_Human1.32791098
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32111083
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31891802
63P68_20966046_ChIP-Seq_HELA_Human1.29677590
64CTCF_20526341_ChIP-Seq_ESCs_Human1.28050694
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26317171
66SA1_27219007_Chip-Seq_Bcells_Human1.25450139
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.25400631
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24747016
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23770032
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22988589
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22686880
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21793169
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.21388570
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20705467
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.20256079
76PU_27001747_Chip-Seq_BMDM_Mouse1.20033824
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.19803652
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19608760
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.18292971
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17570886
81* P300_27268052_Chip-Seq_Bcells_Human1.17487435
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16921149
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15583371
84MYB_26560356_Chip-Seq_TH2_Human1.15077381
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15007514
86GATA3_26560356_Chip-Seq_TH2_Human1.14678478
87RUNX_20019798_ChIP-Seq_JUKART_Human1.13999069
88* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13844636
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13763170
90* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12772017
91VDR_24787735_ChIP-Seq_THP-1_Human1.11495336
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11313495
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09308638
94* E2F1_20622854_ChIP-Seq_HELA_Human1.08893184
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08629779
96SPI1_20517297_ChIP-Seq_HL60_Human1.08315339
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07343946
98VDR_21846776_ChIP-Seq_THP-1_Human1.06575375
99* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05794725
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.05669702
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03286213
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01688596
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01193270
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00247760
105* PHF8_20622854_ChIP-Seq_HELA_Human0.99301918
106* NANOG_20526341_ChIP-Seq_ESCs_Human0.99216769
107GATA3_27048872_Chip-Seq_THYMUS_Human0.96533419
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95763790
109GABP_17652178_ChIP-ChIP_JURKAT_Human0.94608177
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94499359
111EGR1_19032775_ChIP-ChIP_M12_Human0.91186172
112MYB_26560356_Chip-Seq_TH1_Human0.89025227
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87807101
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87363644
115SOX2_20726797_ChIP-Seq_SW620_Human0.85016426
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84340352
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83124216
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82187592
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82187592
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82069001
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81420389
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80889738
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79164725
124MAF_26560356_Chip-Seq_TH1_Human0.78370604
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77962389
126SPI1_23127762_ChIP-Seq_K562_Human0.76519667
127STAT1_20625510_ChIP-Seq_HELA_Human0.75781640
128AR_20517297_ChIP-Seq_VCAP_Human0.74306341
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73703807
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.72835402
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.72339599
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71703728
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69581050
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68488536
135* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.68483998
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68264727
137ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66867473
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.66841479
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65442608
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.62990229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.87488308
2MP0002139_abnormal_hepatobiliary_system3.49229306
3MP0002148_abnormal_hypersensitivity_rea3.35613344
4MP0009785_altered_susceptibility_to3.27037089
5MP0003436_decreased_susceptibility_to3.19585002
6MP0003724_increased_susceptibility_to3.18809396
7MP0005058_abnormal_lysosome_morphology2.85408103
8MP0006082_CNS_inflammation2.80986601
9MP0002419_abnormal_innate_immunity2.68430605
10MP0005025_abnormal_response_to2.61567904
11MP0005000_abnormal_immune_tolerance2.61198450
12MP0008004_abnormal_stomach_pH2.60497006
13MP0005387_immune_system_phenotype2.46682582
14MP0001790_abnormal_immune_system2.46682582
15MP0003195_calcinosis2.40695750
16MP0005671_abnormal_response_to2.39594095
17MP0000685_abnormal_immune_system2.30617216
18MP0009840_abnormal_foam_cell2.18749418
19MP0005365_abnormal_bile_salt2.17190993
20MP0005360_urolithiasis2.15899985
21MP0002723_abnormal_immune_serum2.11341316
22MP0002452_abnormal_antigen_presenting2.09367121
23MP0003186_abnormal_redox_activity2.07912117
24MP0001800_abnormal_humoral_immune2.01855552
25MP0005085_abnormal_gallbladder_physiolo2.01396254
26MP0009764_decreased_sensitivity_to1.98807023
27MP0008469_abnormal_protein_level1.89460495
28MP0008875_abnormal_xenobiotic_pharmacok1.88840716
29MP0003191_abnormal_cellular_cholesterol1.85972217
30MP0002138_abnormal_hepatobiliary_system1.83449014
31MP0005464_abnormal_platelet_physiology1.81000796
32MP0001845_abnormal_inflammatory_respons1.80215818
33MP0001819_abnormal_immune_cell1.78579222
34MP0001533_abnormal_skeleton_physiology1.77658500
35MP0002420_abnormal_adaptive_immunity1.76158009
36MP0006036_abnormal_mitochondrial_physio1.71982756
37MP0001853_heart_inflammation1.61688054
38MP0003879_abnormal_hair_cell1.61462415
39MP0005083_abnormal_biliary_tract1.59993450
40MP0003806_abnormal_nucleotide_metabolis1.59934389
41MP0002405_respiratory_system_inflammati1.53133747
42MP0000465_gastrointestinal_hemorrhage1.51248991
43MP0003303_peritoneal_inflammation1.43880183
44MP0002837_dystrophic_cardiac_calcinosis1.39481549
45MP0010155_abnormal_intestine_physiology1.39299658
46MP0003252_abnormal_bile_duct1.35972155
47MP0005379_endocrine/exocrine_gland_phen1.34621041
48MP0002653_abnormal_ependyma_morphology1.34395740
49MP0001764_abnormal_homeostasis1.32978201
50MP0001666_abnormal_nutrient_absorption1.32596351
51MP0004147_increased_porphyrin_level1.31438915
52MP0005670_abnormal_white_adipose1.29756094
53MP0003183_abnormal_peptide_metabolism1.29159270
54MP0000716_abnormal_immune_system1.28976221
55MP0008260_abnormal_autophagy1.28506512
56MP0000343_altered_response_to1.27934252
57MP0003172_abnormal_lysosome_physiology1.27176895
58MP0010329_abnormal_lipoprotein_level1.26417481
59MP0009333_abnormal_splenocyte_physiolog1.24774150
60MP0003075_altered_response_to1.24747662
61MP0005332_abnormal_amino_acid1.23387193
62MP0006054_spinal_hemorrhage1.22682433
63MP0001905_abnormal_dopamine_level1.21741197
64MP0002277_abnormal_respiratory_mucosa1.19105052
65MP0005167_abnormal_blood-brain_barrier1.18809869
66MP0005165_increased_susceptibility_to1.18299387
67MP0009763_increased_sensitivity_to1.17382166
68MP0001756_abnormal_urination1.17363532
69MP0004947_skin_inflammation1.16767856
70MP0002693_abnormal_pancreas_physiology1.16654549
71MP0005310_abnormal_salivary_gland1.13355928
72MP0003011_delayed_dark_adaptation1.13151434
73MP0001663_abnormal_digestive_system1.12623566
74MP0005084_abnormal_gallbladder_morpholo1.11958931
75MP0002006_tumorigenesis1.11397611
76MP0000858_altered_metastatic_potential1.10326808
77MP0000609_abnormal_liver_physiology1.08230025
78MP0009643_abnormal_urine_homeostasis1.07749610
79MP0002254_reproductive_system_inflammat1.07734496
80MP0002998_abnormal_bone_remodeling1.07505657
81MP0003638_abnormal_response/metabolism_1.06689869
82MP0002398_abnormal_bone_marrow1.05457285
83MP0005451_abnormal_body_composition1.04780894
84MP0003690_abnormal_glial_cell1.04470718
85MP0005319_abnormal_enzyme/_coenzyme1.04221883
86MP0004782_abnormal_surfactant_physiolog1.03199587
87MP0002132_abnormal_respiratory_system1.02979855
88MP0005584_abnormal_enzyme/coenzyme_acti1.01959205
89MP0002429_abnormal_blood_cell1.00585584
90MP0004019_abnormal_vitamin_homeostasis1.00111462
91MP0005164_abnormal_response_to0.99385452
92MP0002166_altered_tumor_susceptibility0.99031964
93MP0000689_abnormal_spleen_morphology0.98701307
94MP0000230_abnormal_systemic_arterial0.98637321
95MP0002118_abnormal_lipid_homeostasis0.98595948
96MP0002933_joint_inflammation0.98089597
97MP0003656_abnormal_erythrocyte_physiolo0.97003976
98MP0003763_abnormal_thymus_physiology0.94123919
99MP0001542_abnormal_bone_strength0.93009782
100MP0005410_abnormal_fertilization0.91699441
101MP0005166_decreased_susceptibility_to0.91633982
102MP0003866_abnormal_defecation0.91540084
103MP0000604_amyloidosis0.91139275
104MP0005220_abnormal_exocrine_pancreas0.88253497
105MP0008872_abnormal_physiological_respon0.85896452
106MP0005636_abnormal_mineral_homeostasis0.85554058
107MP0010386_abnormal_urinary_bladder0.85162534
108MP0002876_abnormal_thyroid_physiology0.84038059
109MP0002722_abnormal_immune_system0.83384537
110MP0000372_irregular_coat_pigmentation0.82309312
111MP0001986_abnormal_taste_sensitivity0.81863561
112MP0005408_hypopigmentation0.80331244
113MP0000920_abnormal_myelination0.79621036
114MP0004510_myositis0.79540175
115MP0005390_skeleton_phenotype0.79345323
116MP0000015_abnormal_ear_pigmentation0.78541131
117MP0002295_abnormal_pulmonary_circulatio0.78519116
118MP0003448_altered_tumor_morphology0.78178318
119MP0005075_abnormal_melanosome_morpholog0.77987628
120MP0005535_abnormal_body_temperature0.77488920
121MP0001545_abnormal_hematopoietic_system0.77247535
122MP0005397_hematopoietic_system_phenotyp0.77247535
123MP0009642_abnormal_blood_homeostasis0.75570799
124MP0000249_abnormal_blood_vessel0.75240348
125MP0000681_abnormal_thyroid_gland0.75187647
126MP0003828_pulmonary_edema0.74626589
127MP0005381_digestive/alimentary_phenotyp0.74446091
128MP0000598_abnormal_liver_morphology0.72393839
129MP0009379_abnormal_foot_pigmentation0.72241085
130MP0005174_abnormal_tail_pigmentation0.72126202

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.06089708
2Recurrent abscess formation (HP:0002722)4.97084670
3Recurrent bacterial skin infections (HP:0005406)4.87753866
4Eczematoid dermatitis (HP:0000976)4.65392330
5Recurrent gram-negative bacterial infections (HP:0005420)4.62600719
6Systemic lupus erythematosus (HP:0002725)4.23744972
7Abnormality of macrophages (HP:0004311)3.88034320
8Elevated erythrocyte sedimentation rate (HP:0003565)3.82389601
9Prolonged bleeding time (HP:0003010)3.74389504
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54695751
11Prolonged partial thromboplastin time (HP:0003645)3.33781298
12Recurrent skin infections (HP:0001581)3.22729321
13Joint hemorrhage (HP:0005261)3.17178969
14Acute necrotizing encephalopathy (HP:0006965)3.10156559
15Mediastinal lymphadenopathy (HP:0100721)3.08681402
16Dysostosis multiplex (HP:0000943)3.07562189
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.04700795
18Autoimmune thrombocytopenia (HP:0001973)3.02589495
19Abnormal mitochondria in muscle tissue (HP:0008316)3.01470927
20Mitochondrial inheritance (HP:0001427)2.96811820
21Loss of speech (HP:0002371)2.93273611
22Glomerulonephritis (HP:0000099)2.90974030
23Menorrhagia (HP:0000132)2.87698741
24Progressive neurologic deterioration (HP:0002344)2.85890251
25Acute encephalopathy (HP:0006846)2.79034902
26Myositis (HP:0100614)2.76357456
27Hepatocellular necrosis (HP:0001404)2.76134109
28Basal ganglia calcification (HP:0002135)2.73831647
29Stomatitis (HP:0010280)2.71536403
30Generalized aminoaciduria (HP:0002909)2.69545567
31Progressive macrocephaly (HP:0004481)2.67955260
32Increased cerebral lipofuscin (HP:0011813)2.67892115
33Vasculitis (HP:0002633)2.65714981
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63847243
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63847243
36Axonal loss (HP:0003447)2.63302878
37Gingivitis (HP:0000230)2.62412024
383-Methylglutaconic aciduria (HP:0003535)2.58947969
39Petechiae (HP:0000967)2.55329446
40Complement deficiency (HP:0004431)2.54097639
41Gingival bleeding (HP:0000225)2.53586034
42Xanthomatosis (HP:0000991)2.53520669
43Increased IgM level (HP:0003496)2.52234570
44Obstructive lung disease (HP:0006536)2.49970309
45Chronic obstructive pulmonary disease (HP:0006510)2.49970309
46Polyphagia (HP:0002591)2.48013686
47Reduced antithrombin III activity (HP:0001976)2.47880153
48Conjugated hyperbilirubinemia (HP:0002908)2.47353182
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.45326794
50Abnormality of glycolipid metabolism (HP:0010969)2.45326794
51Abnormality of liposaccharide metabolism (HP:0010968)2.45326794
52Urticaria (HP:0001025)2.43228108
53Intrahepatic cholestasis (HP:0001406)2.43099757
54Poor head control (HP:0002421)2.42517290
55Abnormality of the common coagulation pathway (HP:0010990)2.40114684
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39168207
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38407614
58Recurrent fungal infections (HP:0002841)2.38392341
59Hepatosplenomegaly (HP:0001433)2.37415889
60Mucopolysacchariduria (HP:0008155)2.34891786
61Urinary glycosaminoglycan excretion (HP:0003541)2.34891786
62Purpura (HP:0000979)2.34324327
63Increased CSF lactate (HP:0002490)2.32485151
64Abnormality of the nasal mucosa (HP:0000433)2.30564847
65Recurrent pneumonia (HP:0006532)2.29840500
66Increased intramyocellular lipid droplets (HP:0012240)2.25607525
67Prolonged neonatal jaundice (HP:0006579)2.23450865
68Hypergammaglobulinemia (HP:0010702)2.23366434
69Abnormal ciliary motility (HP:0012262)2.23219637
70Periodontitis (HP:0000704)2.21105765
71Orchitis (HP:0100796)2.20314048
72Mutism (HP:0002300)2.18795350
73Increased muscle lipid content (HP:0009058)2.18226250
74Interstitial pulmonary disease (HP:0006530)2.16370329
75Abnormality of polysaccharide metabolism (HP:0011012)2.16191876
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16191876
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16191876
78Abnormality of complement system (HP:0005339)2.16055591
79Chronic otitis media (HP:0000389)2.15446558
80Dicarboxylic aciduria (HP:0003215)2.14423654
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14423654
82Nuclear cataract (HP:0100018)2.14087869
83Fat malabsorption (HP:0002630)2.13865498
84Hypoglycemic coma (HP:0001325)2.12054358
85Nasal polyposis (HP:0100582)2.10144385
86Abnormal respiratory epithelium morphology (HP:0012253)2.09405585
87Abnormal respiratory motile cilium morphology (HP:0005938)2.09405585
88Recurrent viral infections (HP:0004429)2.08379516
89Abnormal respiratory motile cilium physiology (HP:0012261)2.08076533
90Meningitis (HP:0001287)2.07317219
91Steatorrhea (HP:0002570)2.07291016
92Amyloidosis (HP:0011034)2.06529244
93Gastrointestinal infarctions (HP:0005244)2.06104228
94Epistaxis (HP:0000421)2.05807413
95Respiratory failure (HP:0002878)2.05551934
96Cerebral palsy (HP:0100021)2.03335411
97Exertional dyspnea (HP:0002875)2.02643818
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02276998
99Myocardial infarction (HP:0001658)2.02154654
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01340197
101Abnormality of the intrinsic pathway (HP:0010989)2.00155598
102Type I transferrin isoform profile (HP:0003642)1.99149030
103Abnormal platelet volume (HP:0011876)1.98175172
104Increased mean platelet volume (HP:0011877)1.97963340
105Cerebral edema (HP:0002181)1.97587385
106Retrobulbar optic neuritis (HP:0100654)1.96802126
107Optic neuritis (HP:0100653)1.96802126
108Renal Fanconi syndrome (HP:0001994)1.95146723
109Hyperlipoproteinemia (HP:0010980)1.94098884
110Increased serum ferritin (HP:0003281)1.93934481
111Abnormality of methionine metabolism (HP:0010901)1.93379341
112Pustule (HP:0200039)1.92749475
113Esophageal neoplasm (HP:0100751)1.91467844
114Neoplasm of head and neck (HP:0012288)1.91467844
115Autoimmune hemolytic anemia (HP:0001890)1.91142217
116Impaired platelet aggregation (HP:0003540)1.90414397
117Abnormal platelet function (HP:0011869)1.90414397
118Recurrent cutaneous fungal infections (HP:0011370)1.89600569
119Chronic mucocutaneous candidiasis (HP:0002728)1.89600569
120Lactic acidosis (HP:0003128)1.89465642
121Pathologic fracture (HP:0002756)1.88681560
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88025715
123Glycosuria (HP:0003076)1.86925312
124Abnormality of urine glucose concentration (HP:0011016)1.86925312
125Thrombocytosis (HP:0001894)1.84897649
126Vertebral compression fractures (HP:0002953)1.84868021
127Abnormality of lateral ventricle (HP:0030047)1.84332106
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84315538
129Recurrent lower respiratory tract infections (HP:0002783)1.84137198
130Joint swelling (HP:0001386)1.84095412
131Abnormality of T cell number (HP:0011839)1.83082341
132Nausea (HP:0002018)1.82816965
133Episodic fever (HP:0001954)1.82538697
134Abnormality of T cell physiology (HP:0011840)1.81317039
135Spontaneous hematomas (HP:0007420)1.81293442
136Abnormality of iron homeostasis (HP:0011031)1.81216853
137Hepatic necrosis (HP:0002605)1.81117581
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80102100
139Abnormal pupillary function (HP:0007686)1.80075866
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79856334
141Abnormality of fatty-acid metabolism (HP:0004359)1.79810228
142Pancreatitis (HP:0001733)1.79609473
143Nephritis (HP:0000123)1.78542578
144Opisthotonus (HP:0002179)1.77155122
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.76367315
146Delusions (HP:0000746)1.75436787
147Abnormality of transition element cation homeostasis (HP:0011030)1.74739512
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.74570170
149Malnutrition (HP:0004395)1.74129690
150Growth hormone excess (HP:0000845)1.73231638
151Hypokinesia (HP:0002375)1.72168425
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.71749136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.76522221
2IRAK43.46945188
3TESK23.23167552
4PBK3.17101298
5IRAK32.90989344
6TBK12.83864541
7NME22.76211360
8TYK22.72541407
9TESK12.70733558
10BLK2.60437504
11IKBKE2.31292969
12ERN12.26272861
13VRK22.25447410
14BMPR1B2.24579111
15RIPK42.20153565
16PIM22.16905505
17IKBKB2.14627938
18MAPKAPK31.91636096
19MAPK151.91170417
20KIT1.87769493
21TAOK31.82689118
22JAK31.82475312
23TAOK11.82201473
24TEC1.79998427
25MAP4K21.79434715
26MAP4K11.75628480
27LIMK11.74790549
28STK161.72469337
29BMPR21.72170759
30TXK1.67295490
31MST41.62047068
32BTK1.52520512
33INSRR1.50710737
34ZAP701.42253141
35BMX1.40210941
36PIK3CG1.40055693
37BCKDK1.38665127
38ILK1.34544865
39ADRBK21.33208555
40MAP2K61.31578167
41DAPK31.29076614
42SIK31.28358525
43CSF1R1.28040172
44MAP3K131.27582613
45SYK1.27367818
46JAK11.25377832
47IRAK11.24868231
48MST1R1.24605332
49TGFBR21.24549242
50ABL21.20257749
51NEK91.19875230
52FLT31.18374741
53LYN1.17097070
54GRK71.17085171
55CHUK1.16949003
56GRK11.16391206
57GRK51.16202445
58DAPK11.12342347
59TRIM281.07752550
60IRAK21.07643562
61DAPK21.04623019
62EPHB21.04518602
63ARAF1.02497627
64CSK1.00937002
65LCK0.96020411
66NLK0.93983138
67LRRK20.91191813
68PTK2B0.90686637
69ERBB30.90615145
70EPHB10.88383859
71TLK10.86462783
72LMTK20.86118564
73HCK0.81951074
74EIF2AK20.81778388
75ACVR1B0.81297526
76FGFR40.78881883
77JAK20.77165398
78CLK10.76413872
79CDK190.75424291
80PAK10.75244173
81MUSK0.73851771
82EPHA30.73476766
83PRKCQ0.72368939
84MAP2K20.71044006
85EIF2AK30.69253265
86PAK40.67407477
87MAP2K30.66537416
88PRKG20.66200705
89TGFBR10.66190440
90ITK0.64800439
91VRK10.64329945
92PRKCD0.63928584
93MAP3K30.63232768
94MAP3K50.63028400
95DDR20.62338377
96MET0.56886561
97MAP3K10.56764099
98PDK20.55095874
99YES10.54201128
100FGR0.52973062
101PRKD10.52156751
102CSNK1G30.52059824
103RPS6KA50.50516169
104CAMK2G0.50084535
105FRK0.49782332
106EIF2AK10.49526422
107PIM10.49466688
108HIPK20.48730874
109MAP3K120.48180275
110PINK10.47222965
111MAP3K110.47157610
112MAPK120.46962962
113ABL10.46145479
114TIE10.45442763
115GRK60.45112569
116ADRBK10.44989743
117TNIK0.44046561
118MAPK40.43144879
119PDPK10.40972693
120DYRK1B0.40778639
121CAMK2D0.40403031
122TRPM70.40098782
123FER0.39146821
124MAPKAPK50.37991500
125MOS0.37318352
126RPS6KA60.36156227
127BRAF0.35716581
128MATK0.35704073
129STK100.35503425
130MAPKAPK20.35389855
131PASK0.34263656
132PRKCA0.34235569
133PRKACG0.34129359
134KDR0.33496913
135EGFR0.33198705
136STK40.32491233
137CDC42BPA0.31959130
138CASK0.31918340
139NUAK10.31847901
140IGF1R0.31760145
141PKN10.31539841
142MYLK0.30546702
143TAOK20.30292630
144FES0.29330865
145TNK20.28684388
146ERBB40.27135939

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.82150155
2Protein export_Homo sapiens_hsa030602.65421815
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49041838
4Collecting duct acid secretion_Homo sapiens_hsa049662.45557995
5Graft-versus-host disease_Homo sapiens_hsa053322.31538523
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16626738
7Other glycan degradation_Homo sapiens_hsa005112.15586631
8Allograft rejection_Homo sapiens_hsa053302.03540011
9Leishmaniasis_Homo sapiens_hsa051402.00180762
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.90559420
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.87106098
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80702968
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76735600
14Lysosome_Homo sapiens_hsa041421.73329649
15Complement and coagulation cascades_Homo sapiens_hsa046101.70240546
16Sulfur metabolism_Homo sapiens_hsa009201.69522480
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.68725709
18Legionellosis_Homo sapiens_hsa051341.68596790
19Histidine metabolism_Homo sapiens_hsa003401.67056851
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65414416
21Rheumatoid arthritis_Homo sapiens_hsa053231.63165554
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.62457389
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.60158746
24Pertussis_Homo sapiens_hsa051331.58103050
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57181561
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56502117
27Folate biosynthesis_Homo sapiens_hsa007901.51368096
28Peroxisome_Homo sapiens_hsa041461.49016960
29Malaria_Homo sapiens_hsa051441.47761764
30Steroid biosynthesis_Homo sapiens_hsa001001.47690329
31Type I diabetes mellitus_Homo sapiens_hsa049401.45188117
32Huntingtons disease_Homo sapiens_hsa050161.44819615
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41935312
34Vibrio cholerae infection_Homo sapiens_hsa051101.41236640
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39256109
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38909503
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.37130819
38Caffeine metabolism_Homo sapiens_hsa002321.33450565
39Asthma_Homo sapiens_hsa053101.33400138
40Chemical carcinogenesis_Homo sapiens_hsa052041.31489656
41Measles_Homo sapiens_hsa051621.31223616
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29647966
43Tryptophan metabolism_Homo sapiens_hsa003801.24886890
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.19753031
45African trypanosomiasis_Homo sapiens_hsa051431.17054793
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15764484
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13510805
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.12619992
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10697599
50Mineral absorption_Homo sapiens_hsa049781.08288382
51Phagosome_Homo sapiens_hsa041451.08131083
52Tuberculosis_Homo sapiens_hsa051521.05819374
53Osteoclast differentiation_Homo sapiens_hsa043801.05753243
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05282663
55Fatty acid elongation_Homo sapiens_hsa000621.03306057
56Starch and sucrose metabolism_Homo sapiens_hsa005001.01812865
57Autoimmune thyroid disease_Homo sapiens_hsa053201.01559679
58Oxidative phosphorylation_Homo sapiens_hsa001901.01024039
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99596363
60Proteasome_Homo sapiens_hsa030500.99424515
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97799010
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97019644
63Influenza A_Homo sapiens_hsa051640.95768484
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95190303
65Fructose and mannose metabolism_Homo sapiens_hsa000510.94215348
66Phenylalanine metabolism_Homo sapiens_hsa003600.93192229
67Renin-angiotensin system_Homo sapiens_hsa046140.92688276
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92215959
69beta-Alanine metabolism_Homo sapiens_hsa004100.90510097
70Synaptic vesicle cycle_Homo sapiens_hsa047210.89497824
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89464103
72Hematopoietic cell lineage_Homo sapiens_hsa046400.89417871
73Arachidonic acid metabolism_Homo sapiens_hsa005900.89015486
74Linoleic acid metabolism_Homo sapiens_hsa005910.88956300
75Selenocompound metabolism_Homo sapiens_hsa004500.88911714
76Retinol metabolism_Homo sapiens_hsa008300.86341735
77Herpes simplex infection_Homo sapiens_hsa051680.85161531
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84776170
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84566587
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81020880
81Fat digestion and absorption_Homo sapiens_hsa049750.80695230
82Fatty acid degradation_Homo sapiens_hsa000710.79833841
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79424244
84TNF signaling pathway_Homo sapiens_hsa046680.78917580
85Primary immunodeficiency_Homo sapiens_hsa053400.78096247
86Ribosome_Homo sapiens_hsa030100.78080357
87Sulfur relay system_Homo sapiens_hsa041220.77809274
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77104165
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.72304863
90Pentose phosphate pathway_Homo sapiens_hsa000300.71218144
91Fatty acid metabolism_Homo sapiens_hsa012120.70682278
92Platelet activation_Homo sapiens_hsa046110.70270571
93Metabolic pathways_Homo sapiens_hsa011000.69883214
94Glutathione metabolism_Homo sapiens_hsa004800.69224349
95Prion diseases_Homo sapiens_hsa050200.69217851
96ABC transporters_Homo sapiens_hsa020100.69110122
97Tyrosine metabolism_Homo sapiens_hsa003500.68312802
98Antigen processing and presentation_Homo sapiens_hsa046120.66840604
99PPAR signaling pathway_Homo sapiens_hsa033200.65873135
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65806544
101Salmonella infection_Homo sapiens_hsa051320.64758636
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64611605
103Glycerolipid metabolism_Homo sapiens_hsa005610.64354772
104Ether lipid metabolism_Homo sapiens_hsa005650.63488021
105Galactose metabolism_Homo sapiens_hsa000520.63249869
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62830523
107Cardiac muscle contraction_Homo sapiens_hsa042600.60488746
108Arginine and proline metabolism_Homo sapiens_hsa003300.60009608
109Butanoate metabolism_Homo sapiens_hsa006500.56615898
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56570959
111Shigellosis_Homo sapiens_hsa051310.56179654
112B cell receptor signaling pathway_Homo sapiens_hsa046620.55621564
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55134163
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55077272
115Vitamin digestion and absorption_Homo sapiens_hsa049770.54509887
116Sphingolipid metabolism_Homo sapiens_hsa006000.54246383
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54193548
118Parkinsons disease_Homo sapiens_hsa050120.53503560
119Apoptosis_Homo sapiens_hsa042100.53414900
120Arginine biosynthesis_Homo sapiens_hsa002200.52729169
121Pyrimidine metabolism_Homo sapiens_hsa002400.51553432
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50770897
123Toxoplasmosis_Homo sapiens_hsa051450.48571596
124Hepatitis C_Homo sapiens_hsa051600.48193413
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.47137478
126Chemokine signaling pathway_Homo sapiens_hsa040620.46956508
127Alzheimers disease_Homo sapiens_hsa050100.44821978

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