TMEM220

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.94914139
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.94914139
3L-phenylalanine metabolic process (GO:0006558)6.72564378
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.72564378
5aromatic amino acid family catabolic process (GO:0009074)6.42595575
6tryptophan catabolic process (GO:0006569)5.98713111
7indole-containing compound catabolic process (GO:0042436)5.98713111
8indolalkylamine catabolic process (GO:0046218)5.98713111
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.98479072
10tryptophan metabolic process (GO:0006568)5.73629880
11kynurenine metabolic process (GO:0070189)5.61016190
12epoxygenase P450 pathway (GO:0019373)5.44290450
13bile acid biosynthetic process (GO:0006699)5.35731810
14high-density lipoprotein particle remodeling (GO:0034375)5.22083859
15glyoxylate metabolic process (GO:0046487)5.15886318
16alpha-linolenic acid metabolic process (GO:0036109)5.09168342
17sulfur amino acid catabolic process (GO:0000098)4.94274623
18urea cycle (GO:0000050)4.89976334
19urea metabolic process (GO:0019627)4.89976334
20protein carboxylation (GO:0018214)4.88710177
21peptidyl-glutamic acid carboxylation (GO:0017187)4.88710177
22cysteine metabolic process (GO:0006534)4.85852809
23negative regulation of fibrinolysis (GO:0051918)4.81892127
24regulation of cholesterol esterification (GO:0010872)4.79875946
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69762331
26aromatic amino acid family metabolic process (GO:0009072)4.69117694
27regulation of triglyceride catabolic process (GO:0010896)4.67009557
28regulation of fibrinolysis (GO:0051917)4.66160580
29complement activation, alternative pathway (GO:0006957)4.64965441
30bile acid metabolic process (GO:0008206)4.60498210
31regulation of protein activation cascade (GO:2000257)4.59487708
32reverse cholesterol transport (GO:0043691)4.55191795
33protein-lipid complex remodeling (GO:0034368)4.53983970
34macromolecular complex remodeling (GO:0034367)4.53983970
35plasma lipoprotein particle remodeling (GO:0034369)4.53983970
36phospholipid efflux (GO:0033700)4.50738069
37nitrogen cycle metabolic process (GO:0071941)4.50570038
38tyrosine metabolic process (GO:0006570)4.46237140
39omega-hydroxylase P450 pathway (GO:0097267)4.40950722
40cellular biogenic amine catabolic process (GO:0042402)4.38923403
41amine catabolic process (GO:0009310)4.38923403
42serine family amino acid catabolic process (GO:0009071)4.35160531
43indolalkylamine metabolic process (GO:0006586)4.34413166
44amino-acid betaine metabolic process (GO:0006577)4.33655248
45homocysteine metabolic process (GO:0050667)4.30111138
46regulation of complement activation (GO:0030449)4.28823787
47alpha-amino acid catabolic process (GO:1901606)4.21083911
48acylglycerol homeostasis (GO:0055090)4.20203363
49triglyceride homeostasis (GO:0070328)4.20203363
50oxidative demethylation (GO:0070989)4.16391682
51drug metabolic process (GO:0017144)4.15515324
52imidazole-containing compound metabolic process (GO:0052803)4.12759940
53lysine metabolic process (GO:0006553)4.12365981
54lysine catabolic process (GO:0006554)4.12365981
55drug catabolic process (GO:0042737)4.11703061
56cellular glucuronidation (GO:0052695)4.10846848
57negative regulation of sterol transport (GO:0032372)4.08678619
58negative regulation of cholesterol transport (GO:0032375)4.08678619
59coenzyme catabolic process (GO:0009109)4.04514677
60cholesterol efflux (GO:0033344)4.03697479
61low-density lipoprotein particle remodeling (GO:0034374)4.01234971
62aldehyde catabolic process (GO:0046185)4.01232474
63bile acid and bile salt transport (GO:0015721)4.00669334
64plasma lipoprotein particle clearance (GO:0034381)4.00400383
65S-adenosylmethionine metabolic process (GO:0046500)3.99742431
66cellular ketone body metabolic process (GO:0046950)3.99151037
67polyketide metabolic process (GO:0030638)3.88002120
68doxorubicin metabolic process (GO:0044598)3.88002120
69daunorubicin metabolic process (GO:0044597)3.88002120
70cellular amino acid catabolic process (GO:0009063)3.87091786
71benzene-containing compound metabolic process (GO:0042537)3.82653989
72NAD biosynthetic process (GO:0009435)3.81132640
73arginine metabolic process (GO:0006525)3.78638559
74negative regulation of lipase activity (GO:0060192)3.76855779
75water-soluble vitamin biosynthetic process (GO:0042364)3.76294318
76uronic acid metabolic process (GO:0006063)3.73282100
77glucuronate metabolic process (GO:0019585)3.73282100
78aggressive behavior (GO:0002118)3.73280958
79plasma lipoprotein particle assembly (GO:0034377)3.72334247
80intestinal cholesterol absorption (GO:0030299)3.63492019
81positive regulation of triglyceride lipase activity (GO:0061365)3.63491399
82positive regulation of lipoprotein lipase activity (GO:0051006)3.63491399
83fibrinolysis (GO:0042730)3.62000952
84cellular modified amino acid catabolic process (GO:0042219)3.61209916
85pyridine nucleotide biosynthetic process (GO:0019363)3.59497411
86nicotinamide nucleotide biosynthetic process (GO:0019359)3.59497411
87serine family amino acid metabolic process (GO:0009069)3.57934716
88glutamate metabolic process (GO:0006536)3.57254872
89exogenous drug catabolic process (GO:0042738)3.56460486
90cofactor catabolic process (GO:0051187)3.56231441
91regulation of bile acid biosynthetic process (GO:0070857)3.55261193
92phenylpropanoid metabolic process (GO:0009698)3.54457392
93valine metabolic process (GO:0006573)3.52842070
94very-low-density lipoprotein particle assembly (GO:0034379)3.52568171
95ethanol oxidation (GO:0006069)3.50531917
96plasma lipoprotein particle organization (GO:0071827)3.50463223
97serine family amino acid biosynthetic process (GO:0009070)3.50006175
98glycine metabolic process (GO:0006544)3.49127672
99xenobiotic catabolic process (GO:0042178)3.48552248
100flavonoid metabolic process (GO:0009812)3.48324889
101carboxylic acid catabolic process (GO:0046395)3.48190207
102organic acid catabolic process (GO:0016054)3.48190207
103blood coagulation, intrinsic pathway (GO:0007597)3.47580969
104short-chain fatty acid metabolic process (GO:0046459)3.46973784
105cholesterol homeostasis (GO:0042632)3.45920688
106opsonization (GO:0008228)3.45294923
107carnitine metabolic process (GO:0009437)3.44283728
108ketone body metabolic process (GO:1902224)3.41842953
109sterol homeostasis (GO:0055092)3.41320058
110response to nitrosative stress (GO:0051409)3.37480482
111positive regulation of icosanoid secretion (GO:0032305)3.35702441
112quinone biosynthetic process (GO:1901663)3.30213305
113alkaloid metabolic process (GO:0009820)3.25829336
114ethanol metabolic process (GO:0006067)3.23739832
115positive regulation of fatty acid transport (GO:2000193)3.19776013
116vitamin biosynthetic process (GO:0009110)3.18582719
117branched-chain amino acid metabolic process (GO:0009081)3.15122090
118L-methionine salvage (GO:0071267)3.13979991
119L-methionine biosynthetic process (GO:0071265)3.13979991
120amino acid salvage (GO:0043102)3.13979991
121quinone metabolic process (GO:1901661)3.12120295
122branched-chain amino acid catabolic process (GO:0009083)3.10336715
123DNA deamination (GO:0045006)3.05710197
124cytochrome complex assembly (GO:0017004)2.95932229
125respiratory chain complex IV assembly (GO:0008535)2.90942884
126arginine catabolic process (GO:0006527)2.89038775
127preassembly of GPI anchor in ER membrane (GO:0016254)2.86160819
128xenobiotic metabolic process (GO:0006805)2.83387739
129regulation of icosanoid secretion (GO:0032303)2.77941658
130protein complex biogenesis (GO:0070271)2.72263358
131piRNA metabolic process (GO:0034587)2.67898281
132regulation of hexokinase activity (GO:1903299)2.66867197
133regulation of glucokinase activity (GO:0033131)2.66867197
134dopamine transport (GO:0015872)2.65684539
135monocarboxylic acid catabolic process (GO:0072329)2.65050078
136ubiquinone biosynthetic process (GO:0006744)2.64025353
137fat-soluble vitamin biosynthetic process (GO:0042362)2.60871120
138fatty acid catabolic process (GO:0009062)2.55362563
139mannosylation (GO:0097502)2.51954968
140cellular ketone metabolic process (GO:0042180)2.49013844
141organic cation transport (GO:0015695)2.47632406
142positive regulation of vasculogenesis (GO:2001214)2.46101126
143positive regulation of organic acid transport (GO:0032892)2.44547873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.32491376
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.71278587
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.29073205
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.72320784
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71516800
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.51168479
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43354487
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.58441071
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.31757793
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12877816
11VDR_22108803_ChIP-Seq_LS180_Human3.02840111
12ZNF274_21170338_ChIP-Seq_K562_Hela2.93842276
13IGF1R_20145208_ChIP-Seq_DFB_Human2.56475698
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.49604151
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41389473
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35647268
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24910937
18GATA1_22025678_ChIP-Seq_K562_Human2.06851569
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04313084
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3703768
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88430645
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.88398177
23GBX2_23144817_ChIP-Seq_PC3_Human1.87704078
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83726732
25FUS_26573619_Chip-Seq_HEK293_Human1.80182231
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78919805
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78789087
28EWS_26573619_Chip-Seq_HEK293_Human1.73373231
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70353639
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67655718
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64138304
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59602382
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57680529
34CBP_20019798_ChIP-Seq_JUKART_Human1.57680529
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56591118
36P300_19829295_ChIP-Seq_ESCs_Human1.55937401
37ER_23166858_ChIP-Seq_MCF-7_Human1.54724296
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50168622
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49890520
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48542044
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46376651
42* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.44922141
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44740805
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.43278918
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43278918
46* SOX2_19829295_ChIP-Seq_ESCs_Human1.42846868
47* NANOG_19829295_ChIP-Seq_ESCs_Human1.42846868
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40054992
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37189397
50TP53_22573176_ChIP-Seq_HFKS_Human1.35651174
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34939674
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34524236
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.32521679
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.32225395
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31564927
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31010645
57* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30426330
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29480459
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26872596
60HTT_18923047_ChIP-ChIP_STHdh_Human1.25104272
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24403509
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24338199
63CLOCK_20551151_ChIP-Seq_293T_Human1.23298316
64TCF4_22108803_ChIP-Seq_LS180_Human1.20771267
65NCOR_22424771_ChIP-Seq_293T_Human1.20770211
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19475246
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18447193
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17075105
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.16018206
70NANOG_20526341_ChIP-Seq_ESCs_Human1.15594012
71AR_25329375_ChIP-Seq_VCAP_Human1.15582971
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15379961
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14978146
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14048783
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10674941
76VDR_23849224_ChIP-Seq_CD4+_Human1.09895807
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.09181842
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08790299
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08406993
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08211873
81* FLI1_21867929_ChIP-Seq_TH2_Mouse1.07910125
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07635978
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06754239
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06097423
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05421805
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.04584106
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04416307
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04416307
89TCF4_23295773_ChIP-Seq_U87_Human1.04166143
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03634067
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02755666
92* GATA4_25053715_ChIP-Seq_YYC3_Human1.02574238
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02460446
94STAT3_23295773_ChIP-Seq_U87_Human1.01568920
95* SMAD4_21799915_ChIP-Seq_A2780_Human1.00205715
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99857625
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.99611187
98P53_21459846_ChIP-Seq_SAOS-2_Human0.97886311
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.97804962
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.97599315
101TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97293001
102ERG_20517297_ChIP-Seq_VCAP_Human0.97194110
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94178064
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93645978
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92443172
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92191119
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91774642
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91279258
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91221095
110IRF8_27001747_Chip-Seq_BMDM_Mouse0.90078861
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88518778
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84080021
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79316059
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77916971
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76838136
116* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76597621
117* STAT1_17558387_ChIP-Seq_HELA_Human0.76458618
118SOX2_20726797_ChIP-Seq_SW620_Human0.75957726
119IRF1_19129219_ChIP-ChIP_H3396_Human0.75635515
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.75388068
121* AR_20517297_ChIP-Seq_VCAP_Human0.73174137
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72669021
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72560301
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.69580449
125TAF15_26573619_Chip-Seq_HEK293_Human0.69027714
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68747819
127* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68623276
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68360094
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.68278902
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67514914
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.65548628
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64361564
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.63500668
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63211295
135* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.62902554
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.62783848
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62775560
138* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61413892
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.61365051
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61265588
141EGR1_19032775_ChIP-ChIP_M12_Human0.61139251
142CBP_21632823_ChIP-Seq_H3396_Human0.60546499
143* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57970791
144GATA2_19941826_ChIP-Seq_K562_Human0.57457172
145CRX_20693478_ChIP-Seq_RETINA_Mouse0.56612013
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54346180
147BCAT_22108803_ChIP-Seq_LS180_Human0.52189056
148KDM2B_26808549_Chip-Seq_REH_Human0.51679118
149* FOXA1_25552417_ChIP-Seq_VCAP_Human0.51242000
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51223996
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.51079039
152* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.50722848
153* GATA3_26560356_Chip-Seq_TH2_Human0.50410858
154CDX2_22108803_ChIP-Seq_LS180_Human0.50400526
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.50305464
156TP63_17297297_ChIP-ChIP_HaCaT_Human0.49242852
157VDR_24787735_ChIP-Seq_THP-1_Human0.49037884
158* CEBPB_22108803_ChIP-Seq_LS180_Human0.48489542
159SCL_19346495_ChIP-Seq_HPC-7_Human0.48432275
160TRIM28_21343339_ChIP-Seq_HEK293_Human0.48283020
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.48251021
162RARB_24833708_ChIP-Seq_LIVER_Mouse0.47486597
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46824239
164PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.46728985
165* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45617237
166FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44849161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.44753578
2MP0005360_urolithiasis6.91584667
3MP0005085_abnormal_gallbladder_physiolo6.15808549
4MP0005365_abnormal_bile_salt5.82976151
5MP0008875_abnormal_xenobiotic_pharmacok4.73258860
6MP0003806_abnormal_nucleotide_metabolis3.86648894
7MP0003252_abnormal_bile_duct3.65361431
8MP0010329_abnormal_lipoprotein_level3.31598573
9MP0003195_calcinosis2.94233623
10MP0005083_abnormal_biliary_tract2.90467806
11MP0009840_abnormal_foam_cell2.87633048
12MP0001666_abnormal_nutrient_absorption2.68687516
13MP0005332_abnormal_amino_acid2.64414008
14MP0003191_abnormal_cellular_cholesterol2.39768625
15MP0009697_abnormal_copulation2.18181668
16MP0004019_abnormal_vitamin_homeostasis2.14488258
17MP0002118_abnormal_lipid_homeostasis2.02088744
18MP0000609_abnormal_liver_physiology1.99317482
19MP0002837_dystrophic_cardiac_calcinosis1.91311159
20MP0002138_abnormal_hepatobiliary_system1.89128670
21MP0004147_increased_porphyrin_level1.88121946
22MP0001764_abnormal_homeostasis1.86063356
23MP0005319_abnormal_enzyme/_coenzyme1.83033921
24MP0003868_abnormal_feces_composition1.71978001
25MP0008877_abnormal_DNA_methylation1.68015332
26MP0005075_abnormal_melanosome_morpholog1.67769926
27MP0008872_abnormal_physiological_respon1.65776149
28MP0002102_abnormal_ear_morphology1.50617191
29MP0005584_abnormal_enzyme/coenzyme_acti1.50339194
30MP0003186_abnormal_redox_activity1.50167808
31MP0009764_decreased_sensitivity_to1.45040797
32MP0001986_abnormal_taste_sensitivity1.42394902
33MP0001545_abnormal_hematopoietic_system1.42140336
34MP0005397_hematopoietic_system_phenotyp1.42140336
35MP0000372_irregular_coat_pigmentation1.41876475
36MP0003718_maternal_effect1.41250115
37MP0010386_abnormal_urinary_bladder1.40839325
38MP0002876_abnormal_thyroid_physiology1.35044362
39MP0001968_abnormal_touch/_nociception1.31786348
40MP0009643_abnormal_urine_homeostasis1.30332550
41MP0005551_abnormal_eye_electrophysiolog1.27511433
42MP0002638_abnormal_pupillary_reflex1.25348888
43MP0005647_abnormal_sex_gland1.25303988
44MP0004782_abnormal_surfactant_physiolog1.24112443
45MP0005174_abnormal_tail_pigmentation1.20828159
46MP0001501_abnormal_sleep_pattern1.20566705
47MP0002254_reproductive_system_inflammat1.17873981
48MP0003724_increased_susceptibility_to1.15561897
49MP0003656_abnormal_erythrocyte_physiolo1.15464707
50MP0000015_abnormal_ear_pigmentation1.15352576
51MP0002736_abnormal_nociception_after1.12920166
52MP0001346_abnormal_lacrimal_gland1.12758453
53MP0008469_abnormal_protein_level1.10355071
54MP0009379_abnormal_foot_pigmentation1.10165804
55MP0005670_abnormal_white_adipose1.09789448
56MP0000230_abnormal_systemic_arterial1.07751315
57MP0008004_abnormal_stomach_pH1.07500482
58MP0009763_increased_sensitivity_to1.04357750
59MP0000598_abnormal_liver_morphology1.03357934
60MP0005451_abnormal_body_composition1.02419060
61MP0000566_synostosis1.01601323
62MP0003646_muscle_fatigue1.00600790
63MP0003787_abnormal_imprinting1.00496079
64MP0005084_abnormal_gallbladder_morpholo0.99316089
65MP0006072_abnormal_retinal_apoptosis0.93380240
66MP0005410_abnormal_fertilization0.92112897
67MP0004142_abnormal_muscle_tone0.90361710
68MP0010368_abnormal_lymphatic_system0.89498287
69MP0005636_abnormal_mineral_homeostasis0.89015234
70MP0009642_abnormal_blood_homeostasis0.88892925
71MP0003436_decreased_susceptibility_to0.87856377
72MP0003011_delayed_dark_adaptation0.87589275
73MP0005253_abnormal_eye_physiology0.84510014
74MP0005220_abnormal_exocrine_pancreas0.83298734
75MP0009785_altered_susceptibility_to0.82568534
76MP0002078_abnormal_glucose_homeostasis0.82408414
77MP0000013_abnormal_adipose_tissue0.78651139
78MP0006082_CNS_inflammation0.78535638
79MP0005464_abnormal_platelet_physiology0.78279717
80MP0002822_catalepsy0.78201678
81MP0001835_abnormal_antigen_presentation0.77396041
82MP0005376_homeostasis/metabolism_phenot0.75328320
83MP0002160_abnormal_reproductive_system0.74487618
84MP0006292_abnormal_olfactory_placode0.73324637
85MP0001664_abnormal_digestion0.73034148
86MP0003690_abnormal_glial_cell0.72812550
87MP0006036_abnormal_mitochondrial_physio0.70638111
88MP0002132_abnormal_respiratory_system0.70194993
89MP0006054_spinal_hemorrhage0.69103641
90MP0001984_abnormal_olfaction0.68956853
91MP0004885_abnormal_endolymph0.68772507
92MP0005408_hypopigmentation0.68737084
93MP0009765_abnormal_xenobiotic_induced0.68589878
94MP0000465_gastrointestinal_hemorrhage0.68584703
95MP0004484_altered_response_of0.68044718
96MP0004215_abnormal_myocardial_fiber0.67162304
97MP0002396_abnormal_hematopoietic_system0.66571073
98MP0002928_abnormal_bile_duct0.66406646
99MP0001905_abnormal_dopamine_level0.66093144
100MP0001756_abnormal_urination0.65995244
101MP0003283_abnormal_digestive_organ0.65358853
102MP0004130_abnormal_muscle_cell0.63134456
103MP0008995_early_reproductive_senescence0.63010577
104MP0006276_abnormal_autonomic_nervous0.62645877
105MP0006035_abnormal_mitochondrial_morpho0.62523712
106MP0005646_abnormal_pituitary_gland0.61690757
107MP0002419_abnormal_innate_immunity0.61382923
108MP0002095_abnormal_skin_pigmentation0.60924335
109MP0002272_abnormal_nervous_system0.59862762
110MP0005379_endocrine/exocrine_gland_phen0.59380279
111MP0002971_abnormal_brown_adipose0.59315837
112MP0001845_abnormal_inflammatory_respons0.59083425
113MP0005058_abnormal_lysosome_morphology0.58504252
114MP0005334_abnormal_fat_pad0.58355108
115MP0003075_altered_response_to0.56867098
116MP0000604_amyloidosis0.56459581
117MP0002136_abnormal_kidney_physiology0.56360398
118MP0005025_abnormal_response_to0.55969953
119MP0005535_abnormal_body_temperature0.55958563
120MP0005248_abnormal_Harderian_gland0.52295110
121MP0000639_abnormal_adrenal_gland0.50250516
122MP0008874_decreased_physiological_sensi0.49952738
123MP0000685_abnormal_immune_system0.49787434
124MP0005266_abnormal_metabolism0.47823312
125MP0005448_abnormal_energy_balance0.46616588
126MP0003638_abnormal_response/metabolism_0.46548386
127MP0004381_abnormal_hair_follicle0.46539128
128MP0004883_abnormal_blood_vessel0.45991397
129MP0001790_abnormal_immune_system0.45854675
130MP0005387_immune_system_phenotype0.45854675
131MP0005166_decreased_susceptibility_to0.45150242
132MP0003953_abnormal_hormone_level0.44345879
133MP0003705_abnormal_hypodermis_morpholog0.44301187
134MP0000538_abnormal_urinary_bladder0.42980390
135MP0005645_abnormal_hypothalamus_physiol0.42791064
136MP0004043_abnormal_pH_regulation0.41366730
137MP0004264_abnormal_extraembryonic_tissu0.40946056
138MP0001533_abnormal_skeleton_physiology0.40836955
139MP0000249_abnormal_blood_vessel0.40623948
140MP0001853_heart_inflammation0.39303902
141MP0005164_abnormal_response_to0.35770457
142MP0002148_abnormal_hypersensitivity_rea0.35625280
143MP0001944_abnormal_pancreas_morphology0.35608085
144MP0003183_abnormal_peptide_metabolism0.35401744
145MP0002693_abnormal_pancreas_physiology0.35217490
146MP0009115_abnormal_fat_cell0.35079206

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.08101280
2Intrahepatic cholestasis (HP:0001406)6.57879794
3Prolonged partial thromboplastin time (HP:0003645)6.19867487
4Deep venous thrombosis (HP:0002625)6.13758085
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.79913811
6Xanthomatosis (HP:0000991)5.51918092
7Hypobetalipoproteinemia (HP:0003563)5.28335233
8Hyperlipoproteinemia (HP:0010980)4.95125989
9Joint hemorrhage (HP:0005261)4.63138131
10Complement deficiency (HP:0004431)4.48348869
11Hyperammonemia (HP:0001987)4.22481485
12Hypoglycemic coma (HP:0001325)4.10410406
13Hyperglycinemia (HP:0002154)4.00227965
14Epidermoid cyst (HP:0200040)3.99178371
15Conjugated hyperbilirubinemia (HP:0002908)3.99075106
16Abnormality of the common coagulation pathway (HP:0010990)3.97788591
17Hypolipoproteinemia (HP:0010981)3.96443686
18Ketosis (HP:0001946)3.95051807
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94287316
20Fat malabsorption (HP:0002630)3.93037409
21Abnormality of the intrinsic pathway (HP:0010989)3.84115981
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73053594
23Hyperglycinuria (HP:0003108)3.68709695
24Abnormality of glycine metabolism (HP:0010895)3.64950705
25Abnormality of serine family amino acid metabolism (HP:0010894)3.64950705
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.60833824
27Abnormality of fatty-acid metabolism (HP:0004359)3.58423901
28Hypoalphalipoproteinemia (HP:0003233)3.51556264
29Abnormality of methionine metabolism (HP:0010901)3.50420630
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.49853244
31Hypercholesterolemia (HP:0003124)3.43261541
32Abnormality of pyrimidine metabolism (HP:0004353)3.43179114
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36109195
34Abnormality of complement system (HP:0005339)3.33624111
35Hypoglycemic seizures (HP:0002173)3.23908699
36Hyperbilirubinemia (HP:0002904)3.21208286
37Generalized aminoaciduria (HP:0002909)3.15811856
38Steatorrhea (HP:0002570)3.09701953
39Abnormality of nucleobase metabolism (HP:0010932)2.99418830
40Vascular calcification (HP:0004934)2.95907313
41Myocardial infarction (HP:0001658)2.94089023
42Systemic lupus erythematosus (HP:0002725)2.91677988
43Methylmalonic acidemia (HP:0002912)2.91601882
44Delayed CNS myelination (HP:0002188)2.90370871
45Ketoacidosis (HP:0001993)2.88164916
46Abnormality of vitamin B metabolism (HP:0004340)2.87066613
47Pancreatic cysts (HP:0001737)2.86768739
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82766128
49Dicarboxylic aciduria (HP:0003215)2.82766128
50Spontaneous abortion (HP:0005268)2.81203272
51Methylmalonic aciduria (HP:0012120)2.79807171
52Metabolic acidosis (HP:0001942)2.79701047
53Congenital stationary night blindness (HP:0007642)2.79033060
54Abnormality of purine metabolism (HP:0004352)2.77538688
55Abnormality of the vitamin B12 metabolism (HP:0004341)2.74825352
56Recurrent gram-negative bacterial infections (HP:0005420)2.74171693
57Abnormality of serum amino acid levels (HP:0003112)2.67943617
58Abolished electroretinogram (ERG) (HP:0000550)2.67622297
59Decreased central vision (HP:0007663)2.67011508
60Cardiovascular calcification (HP:0011915)2.66086646
61Hepatic necrosis (HP:0002605)2.63145885
62Abnormality of vitamin metabolism (HP:0100508)2.62951233
63Abnormality of the renal cortex (HP:0011035)2.62544361
64Pancreatic fibrosis (HP:0100732)2.61288066
65Mitral stenosis (HP:0001718)2.56368715
66Symptomatic seizures (HP:0011145)2.55245393
67Metaphyseal dysplasia (HP:0100255)2.51155598
68Hepatocellular carcinoma (HP:0001402)2.49538805
69Lethargy (HP:0001254)2.44378485
70True hermaphroditism (HP:0010459)2.43585156
71Alopecia of scalp (HP:0002293)2.42697486
72Hepatocellular necrosis (HP:0001404)2.42628205
73Pancreatitis (HP:0001733)2.41713071
74Mitochondrial inheritance (HP:0001427)2.39522925
75Elevated erythrocyte sedimentation rate (HP:0003565)2.36790453
76Opisthotonus (HP:0002179)2.36693285
77Gingival bleeding (HP:0000225)2.32638249
78Acute encephalopathy (HP:0006846)2.32213222
79Renal cortical cysts (HP:0000803)2.29174007
80Cerebral edema (HP:0002181)2.28940680
81Hydroxyprolinuria (HP:0003080)2.27357508
82Abnormality of proline metabolism (HP:0010907)2.27357508
83Enlarged kidneys (HP:0000105)2.25086718
84Abnormal rod and cone electroretinograms (HP:0008323)2.23748767
85Increased CSF lactate (HP:0002490)2.23320046
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22610174
87Abnormality of alanine metabolism (HP:0010916)2.22610174
88Hyperalaninemia (HP:0003348)2.22610174
89Attenuation of retinal blood vessels (HP:0007843)2.22306547
90Skin nodule (HP:0200036)2.21863690
91Abnormality of midbrain morphology (HP:0002418)2.19629365
92Molar tooth sign on MRI (HP:0002419)2.19629365
93Hypothermia (HP:0002045)2.18894124
94Nephronophthisis (HP:0000090)2.18189672
95Menorrhagia (HP:0000132)2.17419389
96Abnormal gallbladder morphology (HP:0012437)2.17245024
97Hyperinsulinemic hypoglycemia (HP:0000825)2.16976573
98Abnormality of urine glucose concentration (HP:0011016)2.16974526
99Glycosuria (HP:0003076)2.16974526
100Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16697219
101Thrombophlebitis (HP:0004418)2.14785643
102Hyperventilation (HP:0002883)2.14258117
103Acute necrotizing encephalopathy (HP:0006965)2.14078977
104Amyloidosis (HP:0011034)2.13505341
105Glomerulonephritis (HP:0000099)2.13025212
106Abnormal biliary tract physiology (HP:0012439)2.10533792
107Bile duct proliferation (HP:0001408)2.10533792
108Vomiting (HP:0002013)2.10219069
109Decreased circulating renin level (HP:0003351)2.09786295
110Hypochromic microcytic anemia (HP:0004840)2.07956987
111Progressive macrocephaly (HP:0004481)2.06877632
112Abnormality of the heme biosynthetic pathway (HP:0010472)2.05244153
113Irritability (HP:0000737)2.02566023
114Reduced antithrombin III activity (HP:0001976)2.01113972
115Stomatitis (HP:0010280)1.99602293
116Pigmentary retinal degeneration (HP:0001146)1.98990202
117Gout (HP:0001997)1.97889170
118Abnormal protein N-linked glycosylation (HP:0012347)1.97118089
119Abnormal protein glycosylation (HP:0012346)1.97118089
120Abnormal glycosylation (HP:0012345)1.97118089
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97118089
122Acanthocytosis (HP:0001927)1.96770879
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96058116
124Progressive inability to walk (HP:0002505)1.95411559
125Cholelithiasis (HP:0001081)1.94976826
126Hyperglycemia (HP:0003074)1.94667118
127Medial flaring of the eyebrow (HP:0010747)1.94387378
128Elevated hepatic transaminases (HP:0002910)1.94280061
129Axonal loss (HP:0003447)1.93492074
130Abnormality of the prostate (HP:0008775)1.93464230
131Lipid accumulation in hepatocytes (HP:0006561)1.92886715
132Esophageal varix (HP:0002040)1.92457071
133Chronic hepatic failure (HP:0100626)1.92182419
134Neonatal onset (HP:0003623)1.91666291
135Malnutrition (HP:0004395)1.91425619
136Abnormality of the renal medulla (HP:0100957)1.90639134
137Fair hair (HP:0002286)1.90445240
138Abnormal enzyme/coenzyme activity (HP:0012379)1.88468404
139Renal Fanconi syndrome (HP:0001994)1.88375030
140Sensorimotor neuropathy (HP:0007141)1.86029912
141Inability to walk (HP:0002540)1.84700252
142Brushfield spots (HP:0001088)1.84160347
143Polydipsia (HP:0001959)1.84125275
144Abnormal drinking behavior (HP:0030082)1.84125275
145Abnormal mitochondria in muscle tissue (HP:0008316)1.83443094
146Cerebral palsy (HP:0100021)1.83369951
147Late onset (HP:0003584)1.83116425
148Proximal tubulopathy (HP:0000114)1.83076129
149Hyperphosphaturia (HP:0003109)1.82414465
150Abnormality of macular pigmentation (HP:0008002)1.82251686
151Cholecystitis (HP:0001082)1.81577743
152Abnormal gallbladder physiology (HP:0012438)1.81577743
153Panhypogammaglobulinemia (HP:0003139)1.81397543
154Nausea (HP:0002018)1.80652308
155Elevated alkaline phosphatase (HP:0003155)1.80280790
156Gaze-evoked nystagmus (HP:0000640)1.79911171
157Type I transferrin isoform profile (HP:0003642)1.79433521
158Thyroiditis (HP:0100646)1.78571739
159Rickets (HP:0002748)1.76549320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.55342844
2SIK14.34872968
3ERN13.52046465
4NUAK13.46033156
5INSRR3.45038100
6TAOK33.22779777
7FGFR43.05899522
8FRK2.76503722
9IRAK32.74134709
10ACVR1B2.62782374
11SIK32.61397221
12MAP4K22.54321765
13MAP3K142.44582797
14PIK3CG2.24972055
15FLT32.22406762
16MAPK152.06766130
17TYK22.00218010
18IRAK41.75131443
19MAPK111.74121431
20NEK91.71137935
21MAP2K31.70548928
22TLK11.64172092
23MST1R1.60928200
24MAP3K131.54487401
25TBK11.49517523
26ADRBK21.43355442
27NLK1.41394892
28ERBB41.34945479
29WNK31.30752611
30GRK11.30152874
31VRK21.27990063
32PRKAA21.26683799
33MAP2K41.25037598
34JAK31.11703028
35IKBKE1.11138992
36TEC1.07302717
37ABL21.06428378
38TNK21.06108259
39IKBKB1.02297463
40CSNK1G11.01538014
41KIT1.01265990
42TIE11.01041247
43MAP3K31.00874598
44MAP2K60.99390556
45SIK20.95719597
46ADRBK10.95108416
47CSNK1G30.93785959
48OXSR10.93053516
49CSF1R0.92166791
50MAP3K70.90606478
51MAPK130.89376323
52PLK20.89335855
53TXK0.87672113
54WNK40.86247816
55PTK60.85919733
56VRK10.85236881
57TAOK20.85148183
58GRK60.84354135
59JAK20.83176026
60IRAK10.81578395
61MST40.81486128
62BTK0.79119372
63ERBB30.78744011
64CSNK1G20.78409228
65AKT30.77775696
66MAP3K40.77328730
67CHUK0.77044898
68LATS10.76622411
69JAK10.76189233
70MAPK40.75915393
71FGFR30.75568576
72PTK2B0.74784472
73PRKCE0.73096043
74STK160.72304722
75TAF10.70561089
76KDR0.70388199
77TRPM70.69894547
78ZAP700.68898492
79CDK80.68408838
80TGFBR20.67825424
81TNIK0.67554616
82GRK50.66845428
83DYRK1B0.65604583
84OBSCN0.64608434
85PRKG20.62690856
86FES0.62522545
87FER0.62126440
88MAPK120.62123346
89BMPR1B0.59146436
90CSK0.58944548
91CAMKK20.57153479
92CDK190.56358415
93FGFR20.56150317
94CSNK1A1L0.55543912
95STK390.54624758
96MYLK0.54301525
97IGF1R0.53876412
98MKNK20.53657211
99BMPR20.53447018
100PRKACA0.53387389
101BLK0.53012993
102RPS6KA50.52765259
103TGFBR10.52536792
104PBK0.51383395
105PIK3CA0.50662029
106PRKACG0.50639309
107PRKCG0.49955841
108MUSK0.49940554
109CASK0.49935533
110ZAK0.49454053
111PTK20.49093545
112EPHA30.48998943
113PRKCA0.48942304
114MKNK10.48050490
115EPHA20.47521017
116MAP3K110.47239342
117EPHB20.45299964
118PDK20.44895157
119HIPK20.44258588
120PLK40.44133253
121PIM20.43920720
122LCK0.43192543
123LYN0.43014226
124MAP2K70.42596945
125ABL10.41745782
126EIF2AK30.41307789
127IRAK20.41228232
128TRIM280.39998615
129ERBB20.39972785
130DAPK20.39889628
131CSNK1A10.38760604
132ITK0.38737107
133GRK70.37306339
134MAPK30.36470040
135MAPK70.35842631
136MAP2K20.35587972
137MAPKAPK50.34875310
138PINK10.34614950
139PRKCZ0.34107669
140PRKCQ0.33923959
141EPHB10.32965689
142SGK20.32697572
143PRKAA10.31670455
144PRKG10.31308020
145SYK0.31285262
146CAMK2G0.30921623
147MAP3K50.30147645
148CAMK40.29820076
149MAP4K10.28588983
150PKN10.28158301

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24290785
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25053183
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99336606
4Tryptophan metabolism_Homo sapiens_hsa003802.75261751
5Arginine biosynthesis_Homo sapiens_hsa002202.66982004
6Nitrogen metabolism_Homo sapiens_hsa009102.62126572
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61088340
8Complement and coagulation cascades_Homo sapiens_hsa046102.60882835
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51095809
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48535235
11Fatty acid degradation_Homo sapiens_hsa000712.48169027
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28041469
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25669211
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25536832
15Peroxisome_Homo sapiens_hsa041462.21451341
16Steroid hormone biosynthesis_Homo sapiens_hsa001402.12578231
17Histidine metabolism_Homo sapiens_hsa003402.12575256
18Chemical carcinogenesis_Homo sapiens_hsa052042.05508088
19Butanoate metabolism_Homo sapiens_hsa006502.02102881
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00088357
21Propanoate metabolism_Homo sapiens_hsa006401.92107396
22Staphylococcus aureus infection_Homo sapiens_hsa051501.87632234
23PPAR signaling pathway_Homo sapiens_hsa033201.82031051
24Folate biosynthesis_Homo sapiens_hsa007901.81503423
25beta-Alanine metabolism_Homo sapiens_hsa004101.78559030
26Fatty acid metabolism_Homo sapiens_hsa012121.75041861
27Caffeine metabolism_Homo sapiens_hsa002321.74739161
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.73709361
29Retinol metabolism_Homo sapiens_hsa008301.71944186
30Phenylalanine metabolism_Homo sapiens_hsa003601.67613061
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63772509
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57608724
33Starch and sucrose metabolism_Homo sapiens_hsa005001.54776249
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52663272
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52015140
36Fatty acid elongation_Homo sapiens_hsa000621.49299664
37Sulfur metabolism_Homo sapiens_hsa009201.48905509
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.48545470
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46168160
40Tyrosine metabolism_Homo sapiens_hsa003501.45171408
41Selenocompound metabolism_Homo sapiens_hsa004501.42122833
42Asthma_Homo sapiens_hsa053101.41653518
43Steroid biosynthesis_Homo sapiens_hsa001001.40477800
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32705417
45Bile secretion_Homo sapiens_hsa049761.26698601
46ABC transporters_Homo sapiens_hsa020101.26134905
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19589642
48Fat digestion and absorption_Homo sapiens_hsa049751.13663772
49Sulfur relay system_Homo sapiens_hsa041221.13649429
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13298266
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10775888
52Pyruvate metabolism_Homo sapiens_hsa006201.10334559
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.07836780
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06669637
55Vitamin digestion and absorption_Homo sapiens_hsa049771.05252744
56Type I diabetes mellitus_Homo sapiens_hsa049401.04758710
57Arginine and proline metabolism_Homo sapiens_hsa003301.02088393
58Carbon metabolism_Homo sapiens_hsa012000.97309812
59Ether lipid metabolism_Homo sapiens_hsa005650.94760623
60Biosynthesis of amino acids_Homo sapiens_hsa012300.92103400
61Oxidative phosphorylation_Homo sapiens_hsa001900.91401445
62Allograft rejection_Homo sapiens_hsa053300.90530671
63Graft-versus-host disease_Homo sapiens_hsa053320.82093092
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.80655602
65Lysine degradation_Homo sapiens_hsa003100.79152216
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78926671
67Autoimmune thyroid disease_Homo sapiens_hsa053200.77404445
68Glutathione metabolism_Homo sapiens_hsa004800.77369488
69Phototransduction_Homo sapiens_hsa047440.70196937
70Parkinsons disease_Homo sapiens_hsa050120.69165861
71Galactose metabolism_Homo sapiens_hsa000520.67177002
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66894836
73Vitamin B6 metabolism_Homo sapiens_hsa007500.65103861
74One carbon pool by folate_Homo sapiens_hsa006700.62228798
75Glycerolipid metabolism_Homo sapiens_hsa005610.61730267
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58270915
77Metabolic pathways_Homo sapiens_hsa011000.51593959
78Fructose and mannose metabolism_Homo sapiens_hsa000510.49896769
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48580601
80Pentose phosphate pathway_Homo sapiens_hsa000300.45617489
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42931701
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42519188
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39996108
84RNA polymerase_Homo sapiens_hsa030200.39087610
85Sphingolipid metabolism_Homo sapiens_hsa006000.38482596
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37179276
87Primary immunodeficiency_Homo sapiens_hsa053400.36319524
88Homologous recombination_Homo sapiens_hsa034400.35587760
89Linoleic acid metabolism_Homo sapiens_hsa005910.34864112
90Serotonergic synapse_Homo sapiens_hsa047260.34204163
91Olfactory transduction_Homo sapiens_hsa047400.33837192
92RNA degradation_Homo sapiens_hsa030180.32738385
93Prion diseases_Homo sapiens_hsa050200.31681482
94Fanconi anemia pathway_Homo sapiens_hsa034600.29764498
95Purine metabolism_Homo sapiens_hsa002300.28078888
96Taste transduction_Homo sapiens_hsa047420.26317172
97Renin secretion_Homo sapiens_hsa049240.26199391
98Pyrimidine metabolism_Homo sapiens_hsa002400.25417575
99Huntingtons disease_Homo sapiens_hsa050160.25092534
100Protein export_Homo sapiens_hsa030600.24252791
101Alzheimers disease_Homo sapiens_hsa050100.23623514
102Antigen processing and presentation_Homo sapiens_hsa046120.23171889
103Salivary secretion_Homo sapiens_hsa049700.22143670
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22001582
105Rheumatoid arthritis_Homo sapiens_hsa053230.20276230
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19176791
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18870961
108Insulin resistance_Homo sapiens_hsa049310.17383938
109Arachidonic acid metabolism_Homo sapiens_hsa005900.15701223
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.14212393
111African trypanosomiasis_Homo sapiens_hsa051430.10321657
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09339775
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06403791
114Ovarian steroidogenesis_Homo sapiens_hsa049130.04928650
115Pertussis_Homo sapiens_hsa051330.03143996
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.02612348
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.01382972
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00629378
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.00499508
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0909766
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0874802
122Renin-angiotensin system_Homo sapiens_hsa04614-0.0816196
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0710701
124Lysosome_Homo sapiens_hsa04142-0.0691219
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0609761
126Legionellosis_Homo sapiens_hsa05134-0.0543530
127Regulation of autophagy_Homo sapiens_hsa04140-0.0460455
128Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0413517
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0327540
130Mineral absorption_Homo sapiens_hsa04978-0.0194816
131Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0079787

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