TMEM221

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)5.89936575
2ribosomal small subunit assembly (GO:0000028)5.72505298
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.23903806
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23903806
5intestinal cholesterol absorption (GO:0030299)5.21205348
6protein retention in ER lumen (GO:0006621)5.11987703
7pentose metabolic process (GO:0019321)4.98291032
8viral transcription (GO:0019083)4.97609028
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.91560988
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.89109518
11regulation of non-canonical Wnt signaling pathway (GO:2000050)4.82837935
12antigen processing and presentation of endogenous antigen (GO:0019883)4.81784438
13translational termination (GO:0006415)4.79044348
14regulation of gamma-delta T cell differentiation (GO:0045586)4.69647366
15regulation of interferon-beta biosynthetic process (GO:0045357)4.67164311
16ribosomal small subunit biogenesis (GO:0042274)4.64156733
17positive regulation of gamma-delta T cell activation (GO:0046645)4.52366070
18regulation of somitogenesis (GO:0014807)4.41771784
19regulation of gamma-delta T cell activation (GO:0046643)4.37402249
20pathway-restricted SMAD protein phosphorylation (GO:0060389)4.29698966
21ribosomal large subunit biogenesis (GO:0042273)4.17604941
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.12826213
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.12826213
24regulation of B cell receptor signaling pathway (GO:0050855)4.05200143
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03460689
26positive regulation of interferon-alpha production (GO:0032727)4.02726303
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01544899
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.01544899
29modulation by symbiont of host immune response (GO:0052553)4.01544899
30positive regulation by symbiont of host defense response (GO:0052509)4.01544899
31modulation by symbiont of host defense response (GO:0052031)4.01544899
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01544899
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.00386007
34translational elongation (GO:0006414)4.00133149
35auditory receptor cell differentiation (GO:0042491)3.86037174
36regulation of interferon-alpha production (GO:0032647)3.85220420
37digestion (GO:0007586)3.82340640
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80724983
39glycoprotein catabolic process (GO:0006516)3.68213267
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67449286
41response to muramyl dipeptide (GO:0032495)3.66396384
42piRNA metabolic process (GO:0034587)3.65420181
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.64882940
44behavioral response to nicotine (GO:0035095)3.63462436
45poly(A)+ mRNA export from nucleus (GO:0016973)3.62532176
46viral life cycle (GO:0019058)3.61999060
47cotranslational protein targeting to membrane (GO:0006613)3.60999222
48protein targeting to ER (GO:0045047)3.56809088
49protein polyglutamylation (GO:0018095)3.56771323
50cellular protein complex disassembly (GO:0043624)3.51016721
51positive regulation of gastrulation (GO:2000543)3.49285148
52pyrimidine nucleobase catabolic process (GO:0006208)3.47387410
53L-serine metabolic process (GO:0006563)3.44420738
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43427668
55forebrain morphogenesis (GO:0048853)3.41919642
56antigen processing and presentation via MHC class Ib (GO:0002475)3.41803457
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41668402
58cardiac left ventricle morphogenesis (GO:0003214)3.40548571
59maturation of SSU-rRNA (GO:0030490)3.39365884
60lipopolysaccharide metabolic process (GO:0008653)3.37915867
61positive regulation of protein homooligomerization (GO:0032464)3.37503375
62negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.33090336
63protein localization to endoplasmic reticulum (GO:0070972)3.28862215
64somite development (GO:0061053)3.25973945
65protein complex biogenesis (GO:0070271)3.23874595
66seminiferous tubule development (GO:0072520)3.21274690
67postsynaptic membrane organization (GO:0001941)3.21095760
68leukocyte aggregation (GO:0070486)3.20825757
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.18360181
70NADH dehydrogenase complex assembly (GO:0010257)3.18360181
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18360181
72regulation of T cell tolerance induction (GO:0002664)3.16418404
73macrophage activation involved in immune response (GO:0002281)3.10421233
74purinergic nucleotide receptor signaling pathway (GO:0035590)3.09624956
75protein complex disassembly (GO:0043241)3.09570621
76regulation of type I interferon-mediated signaling pathway (GO:0060338)3.07446130
77negative regulation of leukocyte chemotaxis (GO:0002689)3.07134144
78leukotriene biosynthetic process (GO:0019370)3.05188824
79positive regulation of mitochondrial fission (GO:0090141)3.05175088
80positive thymic T cell selection (GO:0045059)3.03429571
81immunoglobulin mediated immune response (GO:0016064)3.03207509
82neutrophil activation involved in immune response (GO:0002283)3.03118100
83transcytosis (GO:0045056)3.01638050
84limb development (GO:0060173)2.99680813
85appendage development (GO:0048736)2.99680813
86macromolecular complex disassembly (GO:0032984)2.99293755
87neuronal action potential propagation (GO:0019227)2.99081902
88tongue development (GO:0043586)2.98167654
89glycolipid catabolic process (GO:0019377)2.94987522
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.94136390
91response to type I interferon (GO:0034340)2.93373392
92chaperone-mediated protein transport (GO:0072321)2.92244362
93negative regulation of telomere maintenance (GO:0032205)2.91539003
94outer ear morphogenesis (GO:0042473)2.90724446
95negative regulation of cell killing (GO:0031342)2.90518372
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90518372
97DNA methylation involved in gamete generation (GO:0043046)2.90234854
98mitochondrial respiratory chain complex assembly (GO:0033108)2.89692296
99cell proliferation in forebrain (GO:0021846)2.89555875
100type I interferon signaling pathway (GO:0060337)2.89008182
101cellular response to type I interferon (GO:0071357)2.89008182
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87886560
103T cell migration (GO:0072678)2.87782648
104translational initiation (GO:0006413)2.87733268
105response to host immune response (GO:0052572)2.86608003
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86608003
107cardiovascular system development (GO:0072358)2.84552703
108valine metabolic process (GO:0006573)2.84477275
109positive regulation of Notch signaling pathway (GO:0045747)2.81494755
110positive regulation of mast cell activation (GO:0033005)2.79798832
111positive regulation of muscle cell apoptotic process (GO:0010661)2.79242291
112I-kappaB phosphorylation (GO:0007252)2.78050849
113regulation of cilium movement (GO:0003352)2.77403330
114positive regulation of B cell differentiation (GO:0045579)2.75695276
115negative T cell selection (GO:0043383)2.75383402
116phosphorylated carbohydrate dephosphorylation (GO:0046838)2.74647265
117inositol phosphate dephosphorylation (GO:0046855)2.74647265
118positive regulation of neuroblast proliferation (GO:0002052)2.73634938
119nucleobase catabolic process (GO:0046113)2.72801145
120hematopoietic stem cell proliferation (GO:0071425)2.72487379
121interferon-gamma-mediated signaling pathway (GO:0060333)2.72405189
122type B pancreatic cell proliferation (GO:0044342)2.71411204
123sterol catabolic process (GO:0016127)2.70815204
124cholesterol catabolic process (GO:0006707)2.70815204
125nonmotile primary cilium assembly (GO:0035058)2.70245808
126preassembly of GPI anchor in ER membrane (GO:0016254)2.69284575
127negative regulation of erythrocyte differentiation (GO:0045647)2.69244968
128regulation of B cell differentiation (GO:0045577)2.68500844
129lipopolysaccharide biosynthetic process (GO:0009103)2.67650547
130membrane lipid catabolic process (GO:0046466)2.66872008
131microglial cell activation (GO:0001774)2.66642581
132negative thymic T cell selection (GO:0045060)2.66526225
133myeloid dendritic cell differentiation (GO:0043011)2.66473674
134positive regulation of interferon-beta production (GO:0032728)2.66261410
135growth hormone receptor signaling pathway (GO:0060396)2.66133157
136ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.65482502
137positive regulation of leukocyte degranulation (GO:0043302)2.64999103
138response to host defenses (GO:0052200)2.64698417
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64698417
140response to host (GO:0075136)2.64698417
141pinocytosis (GO:0006907)2.62983658
142serine family amino acid catabolic process (GO:0009071)2.62561185
143thymic T cell selection (GO:0045061)2.62390364
144positive regulation of mast cell activation involved in immune response (GO:0033008)2.62171941
145positive regulation of mast cell degranulation (GO:0043306)2.62171941
146cellular component biogenesis (GO:0044085)2.61137529
147leukotriene metabolic process (GO:0006691)2.60205654
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59519589
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59423970
150T cell mediated immunity (GO:0002456)2.57986437
151JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57745126
152DNA strand renaturation (GO:0000733)2.56989503
153positive regulation of catenin import into nucleus (GO:0035413)2.56849071
154positive regulation of heat generation (GO:0031652)2.56288452
155cellular ketone body metabolic process (GO:0046950)2.55550291
156replication fork processing (GO:0031297)2.54625239
157Golgi transport vesicle coating (GO:0048200)2.54152169
158COPI coating of Golgi vesicle (GO:0048205)2.54152169
159inositol phosphate catabolic process (GO:0071545)2.54030836
160mast cell activation (GO:0045576)2.53361393
161epithelial cilium movement (GO:0003351)2.52990845
162regulation of neuroblast proliferation (GO:1902692)2.51238411
163axoneme assembly (GO:0035082)2.51189434
164primitive streak formation (GO:0090009)2.50131671
165interferon-gamma production (GO:0032609)2.49820448
166regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49803901
167detection of mechanical stimulus involved in sensory perception (GO:0050974)2.49519520
168myeloid dendritic cell activation (GO:0001773)2.49075962
169pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48528683
170membrane protein intracellular domain proteolysis (GO:0031293)2.48349574
171positive regulation of antigen processing and presentation (GO:0002579)2.47786938
172interkinetic nuclear migration (GO:0022027)2.47212742
173B cell receptor signaling pathway (GO:0050853)2.46123352
174myeloid cell activation involved in immune response (GO:0002275)2.45846590
175regulation of tolerance induction (GO:0002643)2.45423510
176synaptic vesicle exocytosis (GO:0016079)2.45173718
177cellular extravasation (GO:0045123)2.45132131
178protein import into peroxisome matrix (GO:0016558)2.44249813
179dendritic spine morphogenesis (GO:0060997)2.43860854
180male meiosis I (GO:0007141)2.43842835
181positive regulation of macrophage differentiation (GO:0045651)2.43576255
182ubiquinone biosynthetic process (GO:0006744)2.42405493
183ribonucleoprotein complex biogenesis (GO:0022613)2.42186588
184regulation of mesoderm development (GO:2000380)2.41652532
185ketone body metabolic process (GO:1902224)2.41501793
186negative regulation of cAMP-mediated signaling (GO:0043951)2.41135481
187convergent extension (GO:0060026)2.39348300
188left/right axis specification (GO:0070986)2.38373732
189synaptic transmission, cholinergic (GO:0007271)2.37966958
190nuclear-transcribed mRNA catabolic process (GO:0000956)2.37098598
191regulation of telomere maintenance (GO:0032204)2.36657908
192serine family amino acid biosynthetic process (GO:0009070)2.36515574
193GPI anchor metabolic process (GO:0006505)2.35440239
194ubiquinone metabolic process (GO:0006743)2.34003997
195negative regulation of JUN kinase activity (GO:0043508)2.33756930
196spinal cord development (GO:0021510)2.33199716
197establishment of protein localization to mitochondrial membrane (GO:0090151)2.32958797
198hypothalamus development (GO:0021854)2.32794537
199intracellular protein transmembrane import (GO:0044743)2.32589267
200presynaptic membrane assembly (GO:0097105)2.31758152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.79947646
2EZH2_22144423_ChIP-Seq_EOC_Human5.17702555
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.15152137
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76139712
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.63540882
6VDR_22108803_ChIP-Seq_LS180_Human2.99816330
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98210339
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94619545
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85128581
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.78076884
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.73800163
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.73754025
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73107245
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61733125
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54905966
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.51079421
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49431195
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49307181
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46495668
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42069628
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37253746
22MYC_22102868_ChIP-Seq_BL_Human2.36072412
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.32596608
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24498736
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24015343
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22109351
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19486534
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18400636
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15969034
30MAF_26560356_Chip-Seq_TH1_Human2.15452070
31VDR_21846776_ChIP-Seq_THP-1_Human2.15033581
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10663056
33MYB_26560356_Chip-Seq_TH2_Human2.05924598
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05874828
35RUNX_20019798_ChIP-Seq_JUKART_Human1.99497685
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99051265
37IGF1R_20145208_ChIP-Seq_DFB_Human1.98631264
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96394880
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.96362439
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.95589343
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90835834
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89854703
43ZNF274_21170338_ChIP-Seq_K562_Hela1.86914059
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85032326
45UTX_26944678_Chip-Seq_JUKART_Human1.84829003
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.84628977
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83453810
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83312140
49FUS_26573619_Chip-Seq_HEK293_Human1.82746633
50VDR_24763502_ChIP-Seq_THP-1_Human1.81882633
51TCF7_22412390_ChIP-Seq_EML_Mouse1.81464450
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.80150827
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77632143
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.77584525
55SPI1_23547873_ChIP-Seq_NB4_Human1.76413087
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.76388750
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75421659
58MYB_26560356_Chip-Seq_TH1_Human1.74987179
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.74015055
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72047477
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.70518019
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70237434
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.69538965
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69256755
65SCL_19346495_ChIP-Seq_HPC-7_Human1.68572732
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65720161
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.62094387
68REST_21632747_ChIP-Seq_MESCs_Mouse1.61000055
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.60917705
70KDM2B_26808549_Chip-Seq_DND41_Human1.60233531
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.59997450
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59954188
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59954188
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.59107166
75MYC_18940864_ChIP-ChIP_HL60_Human1.58988527
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58963128
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58265130
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57560515
79LXR_22292898_ChIP-Seq_THP-1_Human1.57280654
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.57162753
81CLOCK_20551151_ChIP-Seq_293T_Human1.56563210
82GATA1_22025678_ChIP-Seq_K562_Human1.56460043
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50929403
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48731839
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48074791
86* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47821694
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.46975469
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45879889
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43878054
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41731224
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41617329
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41503434
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40115586
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40038087
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39436710
96SPI1_23127762_ChIP-Seq_K562_Human1.39001850
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35983363
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35649658
99MAF_26560356_Chip-Seq_TH2_Human1.35359904
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35228392
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35111016
102RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34900111
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34886948
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34196488
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34085908
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33490497
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32451461
108GATA3_27048872_Chip-Seq_THYMUS_Human1.32330539
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30307155
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.30148231
111RNF2_27304074_Chip-Seq_NSC_Mouse1.28479535
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28035588
113IRF1_19129219_ChIP-ChIP_H3396_Human1.26674167
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24881089
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24261688
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23984925
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23937323
118AR_21572438_ChIP-Seq_LNCaP_Human1.23519254
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22906024
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.21450192
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20949155
122RACK7_27058665_Chip-Seq_MCF-7_Human1.20854950
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19784139
124P300_19829295_ChIP-Seq_ESCs_Human1.16827347
125XRN2_22483619_ChIP-Seq_HELA_Human1.16494955
126ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15519475
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15099531
128GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14843085
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14553547
130* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13956831
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13848530
132EWS_26573619_Chip-Seq_HEK293_Human1.12117316
133MYC_18555785_ChIP-Seq_MESCs_Mouse1.11815958
134PU_27001747_Chip-Seq_BMDM_Mouse1.10213593
135GBX2_23144817_ChIP-Seq_PC3_Human1.10188832
136SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10155944
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.10082391
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09699487
139TP53_20018659_ChIP-ChIP_R1E_Mouse1.09119870
140RXR_22158963_ChIP-Seq_LIVER_Mouse1.08845436
141MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07836344
142ERG_21242973_ChIP-ChIP_JURKAT_Human1.06906824
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06737767
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06542378
145* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06357534
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06250597
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06250597
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05392045
149RING1B_27294783_Chip-Seq_ESCs_Mouse1.04341168
150SOX2_16153702_ChIP-ChIP_HESCs_Human1.04288387
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04258228
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04061232
153POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04036648
154CTCF_27219007_Chip-Seq_Bcells_Human1.03919767
155TP53_22573176_ChIP-Seq_HFKS_Human1.03377871
156EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02279849
157STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01959492
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01937950
159NANOG_20526341_ChIP-Seq_ESCs_Human1.01344396
160FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00680270
161VDR_24787735_ChIP-Seq_THP-1_Human0.99339466
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98937739
163CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98193121
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97433403
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.96915073
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96540325
167RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96377960
168LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96050232
169HOXB7_26014856_ChIP-Seq_BT474_Human0.95474864
170VDR_23849224_ChIP-Seq_CD4+_Human0.93490058
171FOXP3_21729870_ChIP-Seq_TREG_Human0.93309152
172IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93123699
173CBP_20019798_ChIP-Seq_JUKART_Human0.93123699
174SRF_21415370_ChIP-Seq_HL-1_Mouse0.93065484
175TAL1_26923725_Chip-Seq_HPCs_Mouse0.92762452
176SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92751044
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.91946676
178GATA3_21878914_ChIP-Seq_MCF-7_Human0.91505864
179E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91098026
180NCOR_22424771_ChIP-Seq_293T_Human0.90730564
181AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90617743
182GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90331708
183SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90221952
184KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90093620
185TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89983668
186MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89583543
187SMAD3_21741376_ChIP-Seq_ESCs_Human0.88746347
188RUNX1_27514584_Chip-Seq_MCF-7_Human0.88611463
189GATA1_19941827_ChIP-Seq_MEL_Mouse0.87990423
190GABP_19822575_ChIP-Seq_HepG2_Human0.87368824
191OCT4_20526341_ChIP-Seq_ESCs_Human0.87120461
192PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87027591
193ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86886783
194NCOR1_26117541_ChIP-Seq_K562_Human0.86700072
195GATA4_25053715_ChIP-Seq_YYC3_Human0.86573708
196LXR_22158963_ChIP-Seq_LIVER_Mouse0.86197558
197PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85655185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.50054222
2MP0003136_yellow_coat_color4.44433191
3MP0005083_abnormal_biliary_tract3.62843443
4MP0009379_abnormal_foot_pigmentation3.46708065
5MP0001666_abnormal_nutrient_absorption3.31720554
6MP0005058_abnormal_lysosome_morphology3.24556916
7MP0001835_abnormal_antigen_presentation3.16444041
8MP0005377_hearing/vestibular/ear_phenot2.93177658
9MP0003878_abnormal_ear_physiology2.93177658
10MP0003122_maternal_imprinting2.76226225
11MP0003787_abnormal_imprinting2.71261411
12MP0002653_abnormal_ependyma_morphology2.60124169
13MP0005220_abnormal_exocrine_pancreas2.56239871
14MP0003436_decreased_susceptibility_to2.52610383
15MP0000685_abnormal_immune_system2.43541064
16MP0003879_abnormal_hair_cell2.40621317
17MP0005671_abnormal_response_to2.33849107
18MP0003303_peritoneal_inflammation2.31663310
19MP0005387_immune_system_phenotype2.29327834
20MP0001790_abnormal_immune_system2.29327834
21MP0002837_dystrophic_cardiac_calcinosis2.27764808
22MP0001800_abnormal_humoral_immune2.20908182
23MP0003880_abnormal_central_pattern2.18699457
24MP0005000_abnormal_immune_tolerance2.10862983
25MP0003763_abnormal_thymus_physiology2.09408650
26MP0004510_myositis2.05196829
27MP0002452_abnormal_antigen_presenting2.05109243
28MP0002938_white_spotting2.04920427
29MP0003121_genomic_imprinting2.02132258
30MP0003705_abnormal_hypodermis_morpholog2.01938236
31MP0002723_abnormal_immune_serum1.98135572
32MP0002166_altered_tumor_susceptibility1.97356791
33MP0002419_abnormal_innate_immunity1.94745556
34MP0005365_abnormal_bile_salt1.94627038
35MP0005025_abnormal_response_to1.94444998
36MP0002420_abnormal_adaptive_immunity1.93022811
37MP0009840_abnormal_foam_cell1.92558097
38MP0003300_gastrointestinal_ulcer1.91295226
39MP0005171_absent_coat_pigmentation1.90514613
40MP0001819_abnormal_immune_cell1.89700997
41MP0004142_abnormal_muscle_tone1.86805367
42MP0002102_abnormal_ear_morphology1.86598235
43MP0001293_anophthalmia1.86353827
44MP0004859_abnormal_synaptic_plasticity1.85103813
45MP0009785_altered_susceptibility_to1.83994584
46MP0002638_abnormal_pupillary_reflex1.81336471
47MP0005464_abnormal_platelet_physiology1.80643122
48MP0006082_CNS_inflammation1.78233001
49MP0005423_abnormal_somatic_nervous1.78190210
50MP0002148_abnormal_hypersensitivity_rea1.78106816
51MP0001968_abnormal_touch/_nociception1.77313557
52MP0002405_respiratory_system_inflammati1.75443261
53MP0001529_abnormal_vocalization1.73588395
54MP0002163_abnormal_gland_morphology1.71021990
55MP0000778_abnormal_nervous_system1.70005504
56MP0006276_abnormal_autonomic_nervous1.68046787
57MP0004885_abnormal_endolymph1.67044467
58MP0001845_abnormal_inflammatory_respons1.60322856
59MP0001873_stomach_inflammation1.60316094
60MP0002234_abnormal_pharynx_morphology1.60132841
61MP0004947_skin_inflammation1.59905589
62MP0004147_increased_porphyrin_level1.59610775
63MP0000049_abnormal_middle_ear1.59578544
64MP0005394_taste/olfaction_phenotype1.59247026
65MP0005499_abnormal_olfactory_system1.59247026
66MP0008789_abnormal_olfactory_epithelium1.57910031
67MP0002736_abnormal_nociception_after1.57152382
68MP0003172_abnormal_lysosome_physiology1.56418166
69MP0001502_abnormal_circadian_rhythm1.56399656
70MP0003646_muscle_fatigue1.55887209
71MP0005551_abnormal_eye_electrophysiolog1.54582049
72MP0009333_abnormal_splenocyte_physiolog1.54581905
73MP0004145_abnormal_muscle_electrophysio1.54063543
74MP0001533_abnormal_skeleton_physiology1.52791012
75MP0002398_abnormal_bone_marrow1.52071151
76MP0001485_abnormal_pinna_reflex1.51568898
77MP0004133_heterotaxia1.49486685
78MP0000372_irregular_coat_pigmentation1.49423739
79MP0010234_abnormal_vibrissa_follicle1.49209854
80MP0001188_hyperpigmentation1.47009426
81MP0000716_abnormal_immune_system1.46185242
82MP0005174_abnormal_tail_pigmentation1.45836478
83MP0002138_abnormal_hepatobiliary_system1.45044949
84MP0010155_abnormal_intestine_physiology1.44668448
85MP0002272_abnormal_nervous_system1.42272883
86MP0010030_abnormal_orbit_morphology1.42134414
87MP0000631_abnormal_neuroendocrine_gland1.41664561
88MP0005646_abnormal_pituitary_gland1.40931336
89MP0004264_abnormal_extraembryonic_tissu1.40864780
90MP0000689_abnormal_spleen_morphology1.40445656
91MP0003635_abnormal_synaptic_transmissio1.38758575
92MP0003011_delayed_dark_adaptation1.38536285
93MP0003938_abnormal_ear_development1.37517747
94MP0001486_abnormal_startle_reflex1.34941333
95MP0002722_abnormal_immune_system1.33419476
96MP0003191_abnormal_cellular_cholesterol1.33340679
97MP0002572_abnormal_emotion/affect_behav1.33312152
98MP0002006_tumorigenesis1.33015293
99MP0001986_abnormal_taste_sensitivity1.32009215
100MP0009745_abnormal_behavioral_response1.31558368
101MP0002160_abnormal_reproductive_system1.31092883
102MP0002277_abnormal_respiratory_mucosa1.30304827
103MP0008877_abnormal_DNA_methylation1.29430423
104MP0008469_abnormal_protein_level1.29033469
105MP0002429_abnormal_blood_cell1.27965286
106MP0003724_increased_susceptibility_to1.27905342
107MP0002233_abnormal_nose_morphology1.27623514
108MP0006054_spinal_hemorrhage1.26220031
109MP0005310_abnormal_salivary_gland1.25436739
110MP0003937_abnormal_limbs/digits/tail_de1.25381774
111MP0002063_abnormal_learning/memory/cond1.23917600
112MP0001963_abnormal_hearing_physiology1.20159066
113MP0003123_paternal_imprinting1.18268303
114MP0002184_abnormal_innervation1.17908554
115MP0001851_eye_inflammation1.17325298
116MP0002933_joint_inflammation1.16855586
117MP0005670_abnormal_white_adipose1.15110297
118MP0003868_abnormal_feces_composition1.14775543
119MP0000604_amyloidosis1.13116730
120MP0005253_abnormal_eye_physiology1.12443022
121MP0009046_muscle_twitch1.12338849
122MP0001984_abnormal_olfaction1.12167430
123MP0002249_abnormal_larynx_morphology1.09922829
124MP0000490_abnormal_crypts_of1.09613979
125MP0006072_abnormal_retinal_apoptosis1.09439771
126MP0000703_abnormal_thymus_morphology1.09311864
127MP0003755_abnormal_palate_morphology1.08756151
128MP0004808_abnormal_hematopoietic_stem1.08269551
129MP0002557_abnormal_social/conspecific_i1.06480829
130MP0002009_preneoplasia1.05686514
131MP0005390_skeleton_phenotype1.04317508
132MP0000858_altered_metastatic_potential1.04101768
133MP0009278_abnormal_bone_marrow1.03970047
134MP0003448_altered_tumor_morphology1.03185425
135MP0002064_seizures1.02913280
136MP0002752_abnormal_somatic_nervous1.02012979
137MP0001853_heart_inflammation1.00974905
138MP0002095_abnormal_skin_pigmentation1.00382743
139MP0002067_abnormal_sensory_capabilities0.94805569
140MP0005391_vision/eye_phenotype0.94726333
141MP0005084_abnormal_gallbladder_morpholo0.94143055
142MP0000465_gastrointestinal_hemorrhage0.94079411
143MP0009643_abnormal_urine_homeostasis0.93682357
144MP0002882_abnormal_neuron_morphology0.92111176
145MP0002998_abnormal_bone_remodeling0.91661785
146MP0002693_abnormal_pancreas_physiology0.91460301
147MP0002928_abnormal_bile_duct0.91393123
148MP0000955_abnormal_spinal_cord0.90959934
149MP0008438_abnormal_cutaneous_collagen0.90541319
150MP0005379_endocrine/exocrine_gland_phen0.88934321
151MP0003075_altered_response_to0.88279309
152MP0008872_abnormal_physiological_respon0.87929850
153MP0002229_neurodegeneration0.87929189
154MP0001849_ear_inflammation0.87870619
155MP0003566_abnormal_cell_adhesion0.87116178
156MP0005195_abnormal_posterior_eye0.87061543
157MP0001545_abnormal_hematopoietic_system0.86508064
158MP0005397_hematopoietic_system_phenotyp0.86508064
159MP0000678_abnormal_parathyroid_gland0.86333169
160MP0009250_abnormal_appendicular_skeleto0.86197623
161MP0002396_abnormal_hematopoietic_system0.86062897
162MP0002876_abnormal_thyroid_physiology0.85211972
163MP0005389_reproductive_system_phenotype0.85041556
164MP0003453_abnormal_keratinocyte_physiol0.84932165
165MP0002152_abnormal_brain_morphology0.84881374
166MP0003795_abnormal_bone_structure0.84384015
167MP0000566_synostosis0.84355148
168MP0001958_emphysema0.83102772
169MP0003638_abnormal_response/metabolism_0.82600694
170MP0003942_abnormal_urinary_system0.82096049
171MP0000681_abnormal_thyroid_gland0.81787609
172MP0001764_abnormal_homeostasis0.80902530
173MP0002136_abnormal_kidney_physiology0.80410186
174MP0000026_abnormal_inner_ear0.79913273
175MP0002089_abnormal_postnatal_growth/wei0.79490067
176MP0005165_increased_susceptibility_to0.79245239
177MP0005085_abnormal_gallbladder_physiolo0.79236188
178MP0003890_abnormal_embryonic-extraembry0.78654915
179MP0005023_abnormal_wound_healing0.78377561
180MP0001970_abnormal_pain_threshold0.77596040
181MP0004924_abnormal_behavior0.76831976
182MP0005386_behavior/neurological_phenoty0.76831976
183MP0003567_abnormal_fetal_cardiomyocyte0.75980604
184MP0003698_abnormal_male_reproductive0.75881726
185MP0000609_abnormal_liver_physiology0.75872104
186MP0002733_abnormal_thermal_nociception0.75533194
187MP0003137_abnormal_impulse_conducting0.73610599
188MP0003861_abnormal_nervous_system0.73569246
189MP0000343_altered_response_to0.73310624
190MP0001663_abnormal_digestive_system0.68757989
191MP0002135_abnormal_kidney_morphology0.67577160
192MP0000598_abnormal_liver_morphology0.66644846
193MP0003866_abnormal_defecation0.64985484
194MP0005076_abnormal_cell_differentiation0.64648920

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.27403475
2Recurrent bacterial skin infections (HP:0005406)5.16124661
3Unilateral renal agenesis (HP:0000122)4.87914029
4Mixed hearing impairment (HP:0000410)4.62578691
5Recurrent abscess formation (HP:0002722)4.50377005
6Reticulocytopenia (HP:0001896)4.20326555
7Vacuolated lymphocytes (HP:0001922)4.09338756
8Type 2 muscle fiber atrophy (HP:0003554)3.90663541
9Dysostosis multiplex (HP:0000943)3.80191702
10Eczematoid dermatitis (HP:0000976)3.65899695
11Abnormality of cells of the erythroid lineage (HP:0012130)3.63991333
12Increased cerebral lipofuscin (HP:0011813)3.60751966
13Muscle fiber atrophy (HP:0100295)3.54866697
14Myokymia (HP:0002411)3.43313338
15Colon cancer (HP:0003003)3.23871960
16Abnormality of the nasal mucosa (HP:0000433)3.22636301
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.22578496
18Anomalous pulmonary venous return (HP:0010772)3.22439027
19Sclerocornea (HP:0000647)3.21217606
20Abnormal number of erythroid precursors (HP:0012131)3.11007949
21Nasal polyposis (HP:0100582)3.10504836
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.08016614
23Hypoplasia of the fovea (HP:0007750)3.08016614
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07833212
25Abnormality of alanine metabolism (HP:0010916)3.07833212
26Hyperalaninemia (HP:0003348)3.07833212
27Recurrent skin infections (HP:0001581)3.07118594
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.06430270
29Recurrent viral infections (HP:0004429)3.03111776
30Anophthalmia (HP:0000528)3.02143508
31Pustule (HP:0200039)3.01204637
32Bilateral microphthalmos (HP:0007633)2.94573888
33Hypoplastic ischia (HP:0003175)2.92487276
34Abnormality of macrophages (HP:0004311)2.91911376
35Neoplasm of the adrenal cortex (HP:0100641)2.89176342
36Abnormality of the pulmonary veins (HP:0011718)2.86449748
37Systemic lupus erythematosus (HP:0002725)2.83595452
38Chronic otitis media (HP:0000389)2.83494564
39Pancreatic fibrosis (HP:0100732)2.83381103
40Hematochezia (HP:0002573)2.80686986
41Abnormality of the ischium (HP:0003174)2.78518805
42Recurrent fungal infections (HP:0002841)2.76213681
43Interstitial pulmonary disease (HP:0006530)2.75067030
44Urinary glycosaminoglycan excretion (HP:0003541)2.70873823
45Mucopolysacchariduria (HP:0008155)2.70873823
46Gastrointestinal inflammation (HP:0004386)2.70741739
47Colitis (HP:0002583)2.68783329
48Abnormality of the labia minora (HP:0012880)2.67821320
49Medial flaring of the eyebrow (HP:0010747)2.67578081
50Fused cervical vertebrae (HP:0002949)2.67199490
51Inflammation of the large intestine (HP:0002037)2.65164616
52Protuberant abdomen (HP:0001538)2.64974720
53Pancreatic cysts (HP:0001737)2.63938694
54Abnormality of midbrain morphology (HP:0002418)2.61470512
55Molar tooth sign on MRI (HP:0002419)2.61470512
56True hermaphroditism (HP:0010459)2.60132597
57Abnormal vertebral ossification (HP:0100569)2.57316508
58Disinhibition (HP:0000734)2.56941729
59Hyperglycinemia (HP:0002154)2.54562048
60Spontaneous hematomas (HP:0007420)2.52511851
61Elevated erythrocyte sedimentation rate (HP:0003565)2.50782624
62Septo-optic dysplasia (HP:0100842)2.45667952
63IgM deficiency (HP:0002850)2.45470587
64Periodontitis (HP:0000704)2.44187385
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43965611
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43035008
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43035008
68Abnormality of polysaccharide metabolism (HP:0011012)2.43035008
69Occipital encephalocele (HP:0002085)2.42947863
70Abnormality of the fovea (HP:0000493)2.42508130
71Myositis (HP:0100614)2.41618741
72Diastasis recti (HP:0001540)2.40556235
73Multifactorial inheritance (HP:0001426)2.39464809
74Genetic anticipation (HP:0003743)2.38660696
75Retinal dysplasia (HP:0007973)2.35543848
76Macrocytic anemia (HP:0001972)2.35145342
77Rib fusion (HP:0000902)2.33920288
78Fatigue (HP:0012378)2.27274059
79Platyspondyly (HP:0000926)2.27133502
80Pallor (HP:0000980)2.26026473
81Vertebral clefting (HP:0008428)2.25895985
82Urticaria (HP:0001025)2.24363621
83Steatorrhea (HP:0002570)2.24126014
84Pachygyria (HP:0001302)2.23129677
85T lymphocytopenia (HP:0005403)2.22958072
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22845697
87Pendular nystagmus (HP:0012043)2.22079231
88Enlarged epiphyses (HP:0010580)2.21425135
89Joint stiffness (HP:0001387)2.21242919
90Abnormality of liposaccharide metabolism (HP:0010968)2.20486610
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.20486610
92Abnormality of glycolipid metabolism (HP:0010969)2.20486610
93Hypoplastic iliac wings (HP:0002866)2.19923780
94Type II lissencephaly (HP:0007260)2.19593726
95Focal motor seizures (HP:0011153)2.17155559
96Thoracic kyphosis (HP:0002942)2.16649763
97Aplasia/Hypoplasia affecting the retina (HP:0008061)2.15089993
98Loss of speech (HP:0002371)2.13687454
99Congenital stationary night blindness (HP:0007642)2.13631746
100Hepatoblastoma (HP:0002884)2.13215477
101Optic disc pallor (HP:0000543)2.12808428
102Gait imbalance (HP:0002141)2.11974904
103Thrombocytosis (HP:0001894)2.11218411
104Aplasia/Hypoplasia of the macula (HP:0008059)2.11068935
105Anencephaly (HP:0002323)2.10861559
106Abnormality of T cell number (HP:0011839)2.10030826
107Depressed nasal ridge (HP:0000457)2.09938459
108Absent thumb (HP:0009777)2.09758716
109Recurrent gram-negative bacterial infections (HP:0005420)2.07298540
110Progressive cerebellar ataxia (HP:0002073)2.05919955
111Mediastinal lymphadenopathy (HP:0100721)2.05830204
112Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05688728
113Abnormality of the lumbar spine (HP:0100712)2.04506617
114Severe short stature (HP:0003510)2.04483686
115Congenital primary aphakia (HP:0007707)2.04076338
116Nephrogenic diabetes insipidus (HP:0009806)2.03674436
117Recurrent corneal erosions (HP:0000495)2.02757496
118Arterial thrombosis (HP:0004420)2.02529898
119Flared metaphyses (HP:0003015)2.01402025
120Myotonia (HP:0002486)2.00911464
121Renal dysplasia (HP:0000110)2.00896037
122Keratoconjunctivitis sicca (HP:0001097)2.00810664
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00737723
124Abnormality of the pubic bones (HP:0003172)2.00402876
125Facial hemangioma (HP:0000329)2.00125624
126Failure to thrive in infancy (HP:0001531)1.99953123
127Abnormality of the aortic arch (HP:0012303)1.99823488
128Abnormality of the thoracic spine (HP:0100711)1.98246532
129Anterior segment dysgenesis (HP:0007700)1.96802467
130Myocardial infarction (HP:0001658)1.96662567
131Polyphagia (HP:0002591)1.96082990
132Panhypogammaglobulinemia (HP:0003139)1.95769047
133Abnormality of DNA repair (HP:0003254)1.95220607
134Osteolytic defects of the hand bones (HP:0009699)1.92426349
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.92426349
136Abnormality of T cells (HP:0002843)1.91887570
137Hepatocellular necrosis (HP:0001404)1.91430200
138Flattened epiphyses (HP:0003071)1.91420622
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90033757
140Absent epiphyses (HP:0010577)1.90033757
141Enlarged kidneys (HP:0000105)1.88462056
142Abnormality of the renal collecting system (HP:0004742)1.88367156
143Decreased subcutaneous fat (HP:0001002)1.88300154
144Beaking of vertebral bodies (HP:0004568)1.87662201
145Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87336595
146Recurrent bronchitis (HP:0002837)1.87309500
147Exocrine pancreatic insufficiency (HP:0001738)1.87226978
148Focal seizures (HP:0007359)1.86815921
149Recurrent pneumonia (HP:0006532)1.86745723
150Alopecia of scalp (HP:0002293)1.86713738
151Axonal loss (HP:0003447)1.86282144
152Bell-shaped thorax (HP:0001591)1.86036774
153Esophageal varix (HP:0002040)1.84705447
1543-Methylglutaconic aciduria (HP:0003535)1.84210694
155Premature skin wrinkling (HP:0100678)1.82616805
156Abnormal rod and cone electroretinograms (HP:0008323)1.82153473
157Broad foot (HP:0001769)1.82107447
158Squamous cell carcinoma (HP:0002860)1.81933351
159Stenosis of the external auditory canal (HP:0000402)1.81764181
160Glossoptosis (HP:0000162)1.81259538
161Sprengel anomaly (HP:0000912)1.81114114
162Asplenia (HP:0001746)1.80324115
163Adrenal hypoplasia (HP:0000835)1.80014625
164Conjunctival telangiectasia (HP:0000524)1.79421368
165Mitochondrial inheritance (HP:0001427)1.79084976
166Nephronophthisis (HP:0000090)1.78966355
167Supernumerary spleens (HP:0009799)1.78766243
168Optic nerve hypoplasia (HP:0000609)1.78496608
169Annular pancreas (HP:0001734)1.78481254
170Attenuation of retinal blood vessels (HP:0007843)1.78155474
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.77990314
172Acute necrotizing encephalopathy (HP:0006965)1.76927385
173Poikiloderma (HP:0001029)1.76260885
174Glomerulonephritis (HP:0000099)1.75892375
175Decreased central vision (HP:0007663)1.75056750
176Absent septum pellucidum (HP:0001331)1.74970324
177Cerebellar dysplasia (HP:0007033)1.74005203
178Tachypnea (HP:0002789)1.73969881
179Epileptic encephalopathy (HP:0200134)1.72684947
180Limb hypertonia (HP:0002509)1.72627475
181Megalencephaly (HP:0001355)1.69766586
182Abnormal mitochondria in muscle tissue (HP:0008316)1.69641002
183Irregular epiphyses (HP:0010582)1.69265577
184Rectal fistula (HP:0100590)1.68980777
185Rectovaginal fistula (HP:0000143)1.68980777
186Abolished electroretinogram (ERG) (HP:0000550)1.68473875
187Polyuria (HP:0000103)1.67988165
188Polymicrogyria (HP:0002126)1.66957948
189Cystic liver disease (HP:0006706)1.66440347
190Chronic hepatic failure (HP:0100626)1.66226180
191Hepatic necrosis (HP:0002605)1.66060577
192Disproportionate short-trunk short stature (HP:0003521)1.65851680
193Abnormality of reticulocytes (HP:0004312)1.64186347
194Multicystic kidney dysplasia (HP:0000003)1.63884367
195Triphalangeal thumb (HP:0001199)1.61904176
196Genital tract atresia (HP:0001827)1.61768988
197Delayed myelination (HP:0012448)1.61689232
198Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60907483
199Acute encephalopathy (HP:0006846)1.60019752
200Dyskinesia (HP:0100660)1.59948542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.41153639
2MUSK3.97110251
3MAP4K13.73419126
4TRIB33.33346584
5EPHA43.12719946
6CDK192.92808899
7TYK22.91131949
8PKN22.84061008
9ERN12.81579431
10ZAP702.73006434
11BCKDK2.69422918
12BLK2.66447494
13STK38L2.61576070
14PINK12.38869867
15TGFBR22.38114502
16PRKD32.34630117
17TBK12.27924768
18CDC72.14564017
19FRK2.12225761
20PIK3CA2.06986968
21IKBKE2.03605733
22TAF12.02269380
23FGFR42.01542138
24TXK1.96173052
25STK161.92368039
26LRRK21.88396878
27DYRK21.87753050
28ADRBK21.82835755
29NTRK21.82586416
30VRK21.79519213
31JAK31.78866426
32EPHB11.74392254
33NME21.71593948
34KIT1.69699345
35EEF2K1.57921217
36JAK11.56969819
37WNK41.56748397
38MINK11.52842279
39CSF1R1.52522670
40ZAK1.50442645
41MAP3K91.42554162
42BTK1.41141855
43IRAK31.39870916
44MAP2K31.35664610
45MAP2K21.35195318
46TEC1.34753621
47STK101.33958450
48ITK1.33002028
49LATS11.32137689
50TYRO31.31827894
51PAK41.31605841
52CSNK1A1L1.31280597
53PAK61.30568030
54MAP4K21.28848634
55NEK21.27337615
56FLT31.27238131
57CSNK1G21.26308273
58MAPK131.26073578
59MAP3K41.25751443
60CSK1.25337906
61DYRK1B1.24879954
62DAPK21.24629572
63OXSR11.23835888
64MAP2K71.22896972
65PTK61.22675248
66KSR21.21750610
67MAP3K141.20310508
68RIPK11.19635458
69FGFR31.19083067
70SYK1.17404113
71BMPR1B1.16853298
72NME11.16452601
73SCYL21.14909269
74KDR1.14607619
75CSNK1G31.13874719
76GRK61.13797142
77IRAK41.12940735
78MARK11.10773196
79MAP3K101.08901542
80CDK31.08436659
81CSNK1G11.08354027
82TRPM71.05895634
83HCK1.04700511
84SIK11.04097549
85IKBKB1.02652407
86JAK21.00793924
87STK110.97658953
88TGFBR10.97323170
89CDK60.95587079
90STK240.94470633
91FGFR20.94378578
92LCK0.93892036
93MAP2K40.89221020
94FES0.86835874
95PRKCG0.86093112
96NUAK10.85703692
97SIK20.84127818
98MAP3K130.83742186
99RPS6KA40.81683200
100PIM20.81053769
101MARK30.78279944
102LYN0.77947528
103LATS20.77567311
104TESK20.77263713
105PIM10.75003554
106DYRK1A0.74326997
107GRK10.72220713
108CHEK20.71233019
109ADRBK10.70725209
110CAMKK20.70591803
111RIPK40.69930732
112MAPK110.69796598
113STK30.67642503
114STK390.67099003
115PLK10.66262478
116NTRK30.65572442
117UHMK10.65288458
118RAF10.65121240
119CASK0.64480396
120MAP3K30.63682678
121DAPK30.63591879
122CDK80.62563148
123WNK30.61241160
124DAPK10.60216042
125PLK40.58493304
126EPHB20.58335736
127PDGFRB0.58329248
128CAMK10.57778405
129PAK20.55877300
130MKNK20.54421133
131PLK20.54055184
132HIPK20.50718341
133DYRK30.50437164
134AURKA0.50426343
135CSNK1A10.50035687
136CDK50.48228584
137VRK10.48207361
138MAP2K60.47901509
139TIE10.47866818
140BCR0.47632531
141RPS6KB20.46826254
142CHUK0.46452656
143PLK30.46094389
144FGR0.45620804
145MST40.45432795
146ATR0.45130031
147CAMK2A0.44658103
148MAPK150.44336707
149MAP3K80.44301894
150BUB10.44223300
151PRKACA0.43951276
152EGFR0.42936093
153MAP2K10.42502063
154ILK0.41695567
155CDK140.41537814
156CCNB10.41431349
157MKNK10.41229095
158PDK10.41131411
159ABL10.40721244
160RET0.39964645
161PRKCH0.39516349
162GRK50.39423118
163EIF2AK30.39113320
164YES10.39060287
165RPS6KA60.39042645
166MAP3K70.38461691
167TAOK10.38356909
168MAP3K20.36641972
169TAOK30.35180276
170MAP3K110.33053537
171EPHA30.32343915
172NLK0.32175002
173CAMKK10.31694199
174TTN0.31428850
175RPS6KL10.30941013
176RPS6KC10.30941013
177MAP3K120.30253074
178IRAK20.26525626
179MAPK30.25097307
180PRKCQ0.23826114
181MATK0.23773497

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.95450046
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.88858684
3Pancreatic secretion_Homo sapiens_hsa049723.51018992
4Protein digestion and absorption_Homo sapiens_hsa049743.22954165
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.05929370
6Other glycan degradation_Homo sapiens_hsa005112.70646364
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53356276
8Nicotine addiction_Homo sapiens_hsa050332.49023541
9Phototransduction_Homo sapiens_hsa047442.47716556
10Leishmaniasis_Homo sapiens_hsa051402.41449559
11Fat digestion and absorption_Homo sapiens_hsa049752.24047918
12Lysosome_Homo sapiens_hsa041422.17607072
13Oxidative phosphorylation_Homo sapiens_hsa001902.16864235
14Antigen processing and presentation_Homo sapiens_hsa046122.06427466
15Osteoclast differentiation_Homo sapiens_hsa043802.03498526
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.03496359
17Notch signaling pathway_Homo sapiens_hsa043302.01970421
18B cell receptor signaling pathway_Homo sapiens_hsa046622.00037843
19Primary immunodeficiency_Homo sapiens_hsa053401.96889616
20Basal transcription factors_Homo sapiens_hsa030221.94087044
21Measles_Homo sapiens_hsa051621.93542618
22Butanoate metabolism_Homo sapiens_hsa006501.92759191
23Staphylococcus aureus infection_Homo sapiens_hsa051501.89440639
24Fanconi anemia pathway_Homo sapiens_hsa034601.87756831
25Parkinsons disease_Homo sapiens_hsa050121.85838370
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.85129796
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77586758
28Toxoplasmosis_Homo sapiens_hsa051451.73587750
29Basal cell carcinoma_Homo sapiens_hsa052171.68364629
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.68144259
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67986706
32RNA polymerase_Homo sapiens_hsa030201.65835939
33Peroxisome_Homo sapiens_hsa041461.65524870
34Influenza A_Homo sapiens_hsa051641.62687650
35T cell receptor signaling pathway_Homo sapiens_hsa046601.62411672
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61336618
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56559445
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.53395540
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51299072
40Cardiac muscle contraction_Homo sapiens_hsa042601.49334104
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.47629430
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46805530
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46555946
44Hedgehog signaling pathway_Homo sapiens_hsa043401.45419801
45Legionellosis_Homo sapiens_hsa051341.45284352
46Huntingtons disease_Homo sapiens_hsa050161.43451136
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.43298083
48Steroid biosynthesis_Homo sapiens_hsa001001.43162220
49Tuberculosis_Homo sapiens_hsa051521.42319126
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37889959
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37322614
52Arginine and proline metabolism_Homo sapiens_hsa003301.37216276
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34625798
54Pertussis_Homo sapiens_hsa051331.34552678
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32884461
56Alzheimers disease_Homo sapiens_hsa050101.32221410
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31902392
58beta-Alanine metabolism_Homo sapiens_hsa004101.30828377
59Olfactory transduction_Homo sapiens_hsa047401.29308190
60Homologous recombination_Homo sapiens_hsa034401.27932891
61Sulfur relay system_Homo sapiens_hsa041221.25137757
62Viral myocarditis_Homo sapiens_hsa054161.24790765
63Shigellosis_Homo sapiens_hsa051311.23998157
64Hepatitis C_Homo sapiens_hsa051601.21755309
65Morphine addiction_Homo sapiens_hsa050321.20158718
66Apoptosis_Homo sapiens_hsa042101.19719733
67Glycerolipid metabolism_Homo sapiens_hsa005611.18862010
68Chronic myeloid leukemia_Homo sapiens_hsa052201.16855101
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16481809
70Pancreatic cancer_Homo sapiens_hsa052121.15883677
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.12617714
72Folate biosynthesis_Homo sapiens_hsa007901.11670925
73Herpes simplex infection_Homo sapiens_hsa051681.10811407
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09989503
75Caffeine metabolism_Homo sapiens_hsa002321.09430288
76Selenocompound metabolism_Homo sapiens_hsa004501.09101931
77RNA degradation_Homo sapiens_hsa030181.07663609
78Hepatitis B_Homo sapiens_hsa051611.07367989
79VEGF signaling pathway_Homo sapiens_hsa043701.06372775
80One carbon pool by folate_Homo sapiens_hsa006701.06012975
81GABAergic synapse_Homo sapiens_hsa047271.04932054
82Regulation of autophagy_Homo sapiens_hsa041401.04410178
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04341679
84Malaria_Homo sapiens_hsa051441.03970862
85Base excision repair_Homo sapiens_hsa034101.01992838
86Renin-angiotensin system_Homo sapiens_hsa046141.00313910
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99658365
88Taste transduction_Homo sapiens_hsa047420.98844476
89TNF signaling pathway_Homo sapiens_hsa046680.97921967
90Linoleic acid metabolism_Homo sapiens_hsa005910.97586067
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97056028
92Hippo signaling pathway_Homo sapiens_hsa043900.96607489
93Pyrimidine metabolism_Homo sapiens_hsa002400.96594514
94Allograft rejection_Homo sapiens_hsa053300.95220942
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93970284
96Chemokine signaling pathway_Homo sapiens_hsa040620.90499100
97Hematopoietic cell lineage_Homo sapiens_hsa046400.90214771
98Acute myeloid leukemia_Homo sapiens_hsa052210.89077685
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.89043083
100Platelet activation_Homo sapiens_hsa046110.87451662
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87247203
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87085033
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86939740
104Glutamatergic synapse_Homo sapiens_hsa047240.84579110
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83515544
106Tryptophan metabolism_Homo sapiens_hsa003800.82358421
107Dorso-ventral axis formation_Homo sapiens_hsa043200.80178398
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77014537
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.76858262
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76098169
111Graft-versus-host disease_Homo sapiens_hsa053320.75677603
112Purine metabolism_Homo sapiens_hsa002300.75530527
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75278023
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74299707
115Metabolic pathways_Homo sapiens_hsa011000.74203071
116N-Glycan biosynthesis_Homo sapiens_hsa005100.73861455
117Wnt signaling pathway_Homo sapiens_hsa043100.72499236
118Small cell lung cancer_Homo sapiens_hsa052220.72438515
119Rheumatoid arthritis_Homo sapiens_hsa053230.69802290
120Protein export_Homo sapiens_hsa030600.69108328
121Nitrogen metabolism_Homo sapiens_hsa009100.68845246
122Non-small cell lung cancer_Homo sapiens_hsa052230.68082609
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67790837
124Serotonergic synapse_Homo sapiens_hsa047260.67169123
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66479801
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66092454
127Dopaminergic synapse_Homo sapiens_hsa047280.65872358
128Propanoate metabolism_Homo sapiens_hsa006400.65565263
129Arachidonic acid metabolism_Homo sapiens_hsa005900.65119273
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64092455
131Vitamin digestion and absorption_Homo sapiens_hsa049770.63605497
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63466711
133Colorectal cancer_Homo sapiens_hsa052100.62143241
134Retinol metabolism_Homo sapiens_hsa008300.61572979
135Cocaine addiction_Homo sapiens_hsa050300.61546858
136Nucleotide excision repair_Homo sapiens_hsa034200.61290756
137African trypanosomiasis_Homo sapiens_hsa051430.60884354
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.60756806
139Prolactin signaling pathway_Homo sapiens_hsa049170.60186285
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59258160
141Fatty acid elongation_Homo sapiens_hsa000620.58589875
142p53 signaling pathway_Homo sapiens_hsa041150.57952680
143Circadian entrainment_Homo sapiens_hsa047130.57617852
144Synaptic vesicle cycle_Homo sapiens_hsa047210.56379343
145Epstein-Barr virus infection_Homo sapiens_hsa051690.55512813
146Salmonella infection_Homo sapiens_hsa051320.55129724
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54991266
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54566209
149Fatty acid biosynthesis_Homo sapiens_hsa000610.54043225
150Insulin secretion_Homo sapiens_hsa049110.53711247
151Phenylalanine metabolism_Homo sapiens_hsa003600.53234153
152Proteoglycans in cancer_Homo sapiens_hsa052050.51323197
153Ether lipid metabolism_Homo sapiens_hsa005650.51185023
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.49667733
155Calcium signaling pathway_Homo sapiens_hsa040200.49237630
156Endocytosis_Homo sapiens_hsa041440.48935719
157Phagosome_Homo sapiens_hsa041450.48486132
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.46299733
159Cholinergic synapse_Homo sapiens_hsa047250.46232115
160Sphingolipid metabolism_Homo sapiens_hsa006000.45857332
161Collecting duct acid secretion_Homo sapiens_hsa049660.45715615
162Axon guidance_Homo sapiens_hsa043600.45578250
163Focal adhesion_Homo sapiens_hsa045100.45365492
164Biosynthesis of amino acids_Homo sapiens_hsa012300.44404813
165Glutathione metabolism_Homo sapiens_hsa004800.43541776
166Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43434548
167Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41834686
168Histidine metabolism_Homo sapiens_hsa003400.41520967
169Bladder cancer_Homo sapiens_hsa052190.41363981
170Viral carcinogenesis_Homo sapiens_hsa052030.40225769
171Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39497362
172ABC transporters_Homo sapiens_hsa020100.39079187
173Amphetamine addiction_Homo sapiens_hsa050310.37432002
174Endometrial cancer_Homo sapiens_hsa052130.36622838
175Chemical carcinogenesis_Homo sapiens_hsa052040.36537541
176Insulin resistance_Homo sapiens_hsa049310.36236068
177ECM-receptor interaction_Homo sapiens_hsa045120.35864426
178TGF-beta signaling pathway_Homo sapiens_hsa043500.35518140
179HTLV-I infection_Homo sapiens_hsa051660.35293394
180Asthma_Homo sapiens_hsa053100.35170835
181Prostate cancer_Homo sapiens_hsa052150.34126358
182Amoebiasis_Homo sapiens_hsa051460.34087511
183Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33259053
184HIF-1 signaling pathway_Homo sapiens_hsa040660.32901773
185Melanogenesis_Homo sapiens_hsa049160.32836222
186Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30837383
187Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29938543
188Fatty acid degradation_Homo sapiens_hsa000710.28854945
189Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28032594
190Renal cell carcinoma_Homo sapiens_hsa052110.26746693

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