TMEM222

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.78340163
2DNA deamination (GO:0045006)7.66117287
3transcription from mitochondrial promoter (GO:0006390)7.34485189
4proline metabolic process (GO:0006560)7.34038750
5replication fork processing (GO:0031297)6.93483591
6positive regulation of protein homooligomerization (GO:0032464)6.00825857
7oxidative demethylation (GO:0070989)5.70454015
8embryonic process involved in female pregnancy (GO:0060136)5.68573153
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.60411149
10regulation of protein homooligomerization (GO:0032462)5.51588951
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.36915011
12cullin deneddylation (GO:0010388)5.33805801
13viral mRNA export from host cell nucleus (GO:0046784)5.22528299
14DNA strand renaturation (GO:0000733)5.08032493
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.99604899
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.99604899
17protein deneddylation (GO:0000338)4.90022898
18formation of translation preinitiation complex (GO:0001731)4.61436006
19negative regulation of JAK-STAT cascade (GO:0046426)4.60388297
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.59704899
21poly(A)+ mRNA export from nucleus (GO:0016973)4.58607239
22mitochondrial DNA metabolic process (GO:0032042)4.46640843
23telomere maintenance via semi-conservative replication (GO:0032201)4.37403219
24positive regulation of gamma-delta T cell activation (GO:0046645)4.36362757
25GDP-mannose metabolic process (GO:0019673)4.33720436
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24587654
27negative regulation of protein oligomerization (GO:0032460)4.23752552
28base-excision repair, AP site formation (GO:0006285)4.18938791
29DNA double-strand break processing (GO:0000729)4.10173256
30regulation of integrin activation (GO:0033623)4.10096139
31establishment of apical/basal cell polarity (GO:0035089)4.06838782
32base-excision repair (GO:0006284)4.05070707
33DNA integration (GO:0015074)4.01143971
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.97498696
35negative regulation of B cell apoptotic process (GO:0002903)3.95905814
36mRNA cleavage (GO:0006379)3.87587580
37regulation of translational fidelity (GO:0006450)3.84381290
38maturation of 5.8S rRNA (GO:0000460)3.76709485
39pyrimidine nucleotide catabolic process (GO:0006244)3.76515706
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73997902
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.73241060
42establishment of monopolar cell polarity (GO:0061162)3.73241060
43positive regulation of DNA repair (GO:0045739)3.71523805
44tolerance induction (GO:0002507)3.71405278
45cellular response to ATP (GO:0071318)3.69071335
46negative regulation of cell cycle arrest (GO:0071157)3.65670983
47protein neddylation (GO:0045116)3.65626623
48glutamine family amino acid biosynthetic process (GO:0009084)3.59612901
49negative regulation of heart rate (GO:0010459)3.53228001
50mitochondrial RNA metabolic process (GO:0000959)3.48981688
51DNA strand elongation involved in DNA replication (GO:0006271)3.48718602
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.46703786
53positive regulation of developmental pigmentation (GO:0048087)3.44610402
54oxidative phosphorylation (GO:0006119)3.41120874
55iron-sulfur cluster assembly (GO:0016226)3.39861602
56metallo-sulfur cluster assembly (GO:0031163)3.39861602
57mitotic G1 DNA damage checkpoint (GO:0031571)3.39410790
58regulation of B cell apoptotic process (GO:0002902)3.38732550
59telomere maintenance via recombination (GO:0000722)3.38420721
60proteasome assembly (GO:0043248)3.37391178
61DNA strand elongation (GO:0022616)3.36997821
62termination of RNA polymerase II transcription (GO:0006369)3.36071476
63DNA ligation (GO:0006266)3.33839844
64non-recombinational repair (GO:0000726)3.32950686
65double-strand break repair via nonhomologous end joining (GO:0006303)3.32950686
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31018483
67regulation of cilium movement (GO:0003352)3.30549730
68purine deoxyribonucleotide catabolic process (GO:0009155)3.28302129
69DNA demethylation (GO:0080111)3.27979665
70synaptic vesicle endocytosis (GO:0048488)3.27273884
71regulation of cAMP-dependent protein kinase activity (GO:2000479)3.26741525
72protein insertion into membrane (GO:0051205)3.25206800
73regulation of protein oligomerization (GO:0032459)3.25112397
74negative regulation of appetite (GO:0032099)3.22361566
75negative regulation of response to food (GO:0032096)3.22361566
76nucleotide salvage (GO:0043173)3.21046077
77organelle membrane fusion (GO:0090174)3.19439793
78nuclear envelope reassembly (GO:0031468)3.18830472
79mitotic nuclear envelope reassembly (GO:0007084)3.18830472
80purine nucleotide salvage (GO:0032261)3.17240126
81kinetochore assembly (GO:0051382)3.14356758
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13916895
83cellular response to zinc ion (GO:0071294)3.13543304
84actin filament depolymerization (GO:0030042)3.13493314
85spliceosomal tri-snRNP complex assembly (GO:0000244)3.12878963
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.11283219
87negative regulation of mRNA processing (GO:0050686)3.10777642
88G1 DNA damage checkpoint (GO:0044783)3.09927529
89regulation of mitochondrial depolarization (GO:0051900)3.06726244
90convergent extension (GO:0060026)3.03500101
91glial cell migration (GO:0008347)3.02346350
92histone arginine methylation (GO:0034969)3.01265049
93amino sugar catabolic process (GO:0046348)3.00870125
94histone H4-K12 acetylation (GO:0043983)3.00663979
95lipopolysaccharide biosynthetic process (GO:0009103)2.95704526
96protein maturation by protein folding (GO:0022417)2.94634528
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93969962
98mRNA polyadenylation (GO:0006378)2.93669614
99pseudouridine synthesis (GO:0001522)2.93009892
100ATP hydrolysis coupled proton transport (GO:0015991)2.92658641
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.92658641
102mitotic G1/S transition checkpoint (GO:0044819)2.91833381
103telomere maintenance via telomere lengthening (GO:0010833)2.90086436
104peptidyl-arginine omega-N-methylation (GO:0035247)2.88008592
105NIK/NF-kappaB signaling (GO:0038061)2.87443765
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87371155
107pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86728557
108N-acetylneuraminate metabolic process (GO:0006054)2.85982985
109neuromuscular process controlling posture (GO:0050884)2.85722173
110type B pancreatic cell proliferation (GO:0044342)2.83191289
111lipopolysaccharide metabolic process (GO:0008653)2.83046145
112negative regulation of RNA splicing (GO:0033119)2.81815150
113auditory receptor cell stereocilium organization (GO:0060088)2.81311745
114cellular zinc ion homeostasis (GO:0006882)2.79520599
115mitochondrial DNA replication (GO:0006264)2.78920286
116positive regulation of protein oligomerization (GO:0032461)2.78333801
117nodal signaling pathway (GO:0038092)2.77738906
118lysosome localization (GO:0032418)2.77681200
119immunoglobulin mediated immune response (GO:0016064)2.75905687
120single strand break repair (GO:0000012)2.73557447
121regulation of gamma-delta T cell activation (GO:0046643)2.73451739
122embryonic placenta development (GO:0001892)2.73154919
123viral protein processing (GO:0019082)2.73104798
124signal complex assembly (GO:0007172)2.71716687
125succinate metabolic process (GO:0006105)2.71637636
126positive regulation of circadian rhythm (GO:0042753)2.70680507
127positive regulation of receptor recycling (GO:0001921)2.70617322
128negative regulation of Ras GTPase activity (GO:0034261)2.70504178
129regulation of gamma-delta T cell differentiation (GO:0045586)2.69779928
130ribosome biogenesis (GO:0042254)2.69359780
131mitotic recombination (GO:0006312)2.69292247
132nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68847820
133virion assembly (GO:0019068)2.67741004
134L-methionine salvage (GO:0071267)2.65471918
135L-methionine biosynthetic process (GO:0071265)2.65471918
136amino acid salvage (GO:0043102)2.65471918
137phagosome maturation (GO:0090382)2.64659831
138regulation of defense response to virus by virus (GO:0050690)2.64519171
139positive regulation of mitochondrial fission (GO:0090141)2.63989188
140regulation of cellular amino acid metabolic process (GO:0006521)2.63613437
141protein targeting to mitochondrion (GO:0006626)2.63275137
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62428348
143purine deoxyribonucleotide metabolic process (GO:0009151)2.61008188
144positive regulation of TOR signaling (GO:0032008)2.60189460
145cellular metabolic compound salvage (GO:0043094)2.58257932
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57276819
147negative regulation of cell killing (GO:0031342)2.57276819
148deoxyribonucleotide catabolic process (GO:0009264)2.56782761
149mitochondrial calcium ion transport (GO:0006851)2.56595865
150activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.54181771
151positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.53346508
152pyrimidine-containing compound salvage (GO:0008655)2.50549311
153pyrimidine nucleoside salvage (GO:0043097)2.50549311
154establishment of protein localization to mitochondrion (GO:0072655)2.47393572
155guanosine-containing compound biosynthetic process (GO:1901070)2.46477952
156fatty acid elongation (GO:0030497)2.46163613
157mast cell degranulation (GO:0043303)2.45102675
158mast cell activation involved in immune response (GO:0002279)2.45102675
159DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45008741
160pentose-phosphate shunt (GO:0006098)2.44807649
161antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43897175
162regulation of autophagic vacuole assembly (GO:2000785)2.42429603
163CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42175034
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.41368787
165zinc ion homeostasis (GO:0055069)2.40494844
166deoxyribose phosphate catabolic process (GO:0046386)2.40132471
167negative regulation of lymphocyte apoptotic process (GO:0070229)2.39885043
168peptidyl-arginine methylation (GO:0018216)2.39574143
169peptidyl-arginine N-methylation (GO:0035246)2.39574143
170GMP metabolic process (GO:0046037)2.35890957
171response to misfolded protein (GO:0051788)2.33605989
172nucleoside salvage (GO:0043174)2.32692243
173positive regulation of B cell differentiation (GO:0045579)2.32277641
174signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.30685028
175intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.30685028
176synaptic vesicle exocytosis (GO:0016079)2.29699675
177signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.28733282
178signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.28733282
179signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.28733282
180transferrin transport (GO:0033572)2.28689383
181negative regulation of innate immune response (GO:0045824)2.27646452
182regulation of T cell receptor signaling pathway (GO:0050856)2.27374583
183autophagic vacuole fusion (GO:0000046)2.27015199
184negative regulation of leukocyte apoptotic process (GO:2000107)2.26600420
185cytochrome complex assembly (GO:0017004)2.26001126
186leukocyte degranulation (GO:0043299)2.23925986
187regulation of vacuole organization (GO:0044088)2.23622031
188mitochondrial calcium ion homeostasis (GO:0051560)2.22980993
189regulation of regulatory T cell differentiation (GO:0045589)2.22900305
190signal transduction involved in DNA integrity checkpoint (GO:0072401)2.22829578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.35909085
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.27848176
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25539890
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21957248
5THAP11_20581084_ChIP-Seq_MESCs_Mouse3.03399913
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93286594
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78589389
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.59335149
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52431115
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49760820
11YY1_21170310_ChIP-Seq_MESCs_Mouse2.49706431
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.45247629
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33240329
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30850350
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25891781
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24800487
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20627781
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13642816
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.13074886
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.12477453
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.11503488
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.10932142
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.09844659
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.08140245
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06928321
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02682449
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02101240
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98678112
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98678112
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98678112
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.96022083
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93172424
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90997322
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89936318
35* GABP_19822575_ChIP-Seq_HepG2_Human1.88239993
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87928653
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85194663
38PU.1_20513432_ChIP-Seq_Bcells_Mouse1.85172660
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85103057
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84790744
41DCP1A_22483619_ChIP-Seq_HELA_Human1.82881537
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81112431
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79871909
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78907936
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.75371102
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75168361
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.75166167
48CIITA_25753668_ChIP-Seq_RAJI_Human1.73674655
49BCL6_27268052_Chip-Seq_Bcells_Human1.72698768
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71877280
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70424167
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.69776356
53* VDR_21846776_ChIP-Seq_THP-1_Human1.68595577
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67048030
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66095941
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.66079600
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65782332
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65595573
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.64677473
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64533385
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64512748
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.64492583
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.61486616
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60383696
65P68_20966046_ChIP-Seq_HELA_Human1.59618144
66LXR_22292898_ChIP-Seq_THP-1_Human1.58086097
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57964105
68XRN2_22483619_ChIP-Seq_HELA_Human1.57456994
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.56809155
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55544857
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53914017
72MAF_26560356_Chip-Seq_TH2_Human1.53272232
73BCOR_27268052_Chip-Seq_Bcells_Human1.53015781
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52939743
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52317766
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51542231
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51283404
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47846755
79* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47542020
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46439530
81* TTF2_22483619_ChIP-Seq_HELA_Human1.45287022
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44451076
83* UTX_26944678_Chip-Seq_JUKART_Human1.42977356
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42772367
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41248277
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40644338
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40261593
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39580468
89MAF_26560356_Chip-Seq_TH1_Human1.38661397
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38297898
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37181515
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35864757
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33555786
94TFEB_21752829_ChIP-Seq_HELA_Human1.33431910
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32207305
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31978953
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31730476
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.31601058
99* VDR_23849224_ChIP-Seq_CD4+_Human1.31200452
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30894208
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30871819
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30385416
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30173800
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28277110
105SPI1_23547873_ChIP-Seq_NB4_Human1.27541207
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27260696
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26831760
108* SA1_27219007_Chip-Seq_Bcells_Human1.26676379
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26449738
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.26170400
111TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25424209
112PHF8_20622854_ChIP-Seq_HELA_Human1.25421527
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24978782
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24893973
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24483974
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24394291
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.24269204
118KDM5A_27292631_Chip-Seq_BREAST_Human1.23465465
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22302484
120* RACK7_27058665_Chip-Seq_MCF-7_Human1.21257633
121CTCF_20526341_ChIP-Seq_ESCs_Human1.21116248
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20829044
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20675315
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.19740465
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19635581
126E2F1_20622854_ChIP-Seq_HELA_Human1.19587858
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19531806
128* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19347756
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19115073
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18748492
131SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18713478
132DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17943571
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17494311
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16372211
135IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15416987
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15320206
137REST_18959480_ChIP-ChIP_MESCs_Mouse1.14307808
138KDM2B_26808549_Chip-Seq_DND41_Human1.13706315
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13409590
140OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11319361
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10193918
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10063277
143SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08872721
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07584248
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07532313
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06513992
147FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05751621
148RARB_24833708_ChIP-Seq_LIVER_Mouse1.05642321
149E2F7_22180533_ChIP-Seq_HELA_Human1.04889660
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04666814
151ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04607580
152FOXP3_21729870_ChIP-Seq_TREG_Human1.01739667
153STAT1_20625510_ChIP-Seq_HELA_Human1.01710712
154RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01540006
155FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00543876
156FOXP1_21924763_ChIP-Seq_HESCs_Human0.99287357
157MYC_22102868_ChIP-Seq_BL_Human0.99276164
158TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98495114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.37798665
2MP0005171_absent_coat_pigmentation4.58499325
3MP0010030_abnormal_orbit_morphology3.52233122
4MP0004233_abnormal_muscle_weight3.18490312
5MP0009278_abnormal_bone_marrow2.93897915
6MP0002653_abnormal_ependyma_morphology2.88034397
7MP0003436_decreased_susceptibility_to2.68096017
8MP0009840_abnormal_foam_cell2.53869549
9MP0008995_early_reproductive_senescence2.53598765
10MP0003724_increased_susceptibility_to2.43902195
11MP0003191_abnormal_cellular_cholesterol2.36681287
12MP0003011_delayed_dark_adaptation2.36407520
13MP0003806_abnormal_nucleotide_metabolis2.33007598
14MP0005645_abnormal_hypothalamus_physiol2.24610876
15MP0006072_abnormal_retinal_apoptosis2.22670733
16MP0008260_abnormal_autophagy2.19468447
17MP0005464_abnormal_platelet_physiology2.17650748
18MP0003890_abnormal_embryonic-extraembry2.17345150
19MP0005000_abnormal_immune_tolerance2.13703975
20MP0001835_abnormal_antigen_presentation2.12035256
21MP0008877_abnormal_DNA_methylation2.08096252
22MP0004133_heterotaxia2.07924842
23MP0005671_abnormal_response_to2.07071488
24MP0010094_abnormal_chromosome_stability2.06131668
25MP0003303_peritoneal_inflammation2.04767373
26MP0002009_preneoplasia2.03242303
27MP0004142_abnormal_muscle_tone2.02695188
28MP0006082_CNS_inflammation1.98601089
29MP0004957_abnormal_blastocyst_morpholog1.98179838
30MP0003786_premature_aging1.94942113
31MP0008058_abnormal_DNA_repair1.94037988
32MP0003880_abnormal_central_pattern1.92533779
33MP0009333_abnormal_splenocyte_physiolog1.88085809
34MP0003763_abnormal_thymus_physiology1.87909374
35MP0003119_abnormal_digestive_system1.85258029
36MP0009046_muscle_twitch1.84707795
37MP0003172_abnormal_lysosome_physiology1.83482653
38MP0009785_altered_susceptibility_to1.82588737
39MP0005397_hematopoietic_system_phenotyp1.79970682
40MP0001545_abnormal_hematopoietic_system1.79970682
41MP0005025_abnormal_response_to1.78945134
42MP0004859_abnormal_synaptic_plasticity1.77109490
43MP0004147_increased_porphyrin_level1.76440569
44MP0000604_amyloidosis1.74153970
45MP0002148_abnormal_hypersensitivity_rea1.73681301
46MP0005174_abnormal_tail_pigmentation1.72940125
47MP0008932_abnormal_embryonic_tissue1.66566778
48MP0002572_abnormal_emotion/affect_behav1.66484106
49MP0006035_abnormal_mitochondrial_morpho1.63831523
50MP0000015_abnormal_ear_pigmentation1.63811734
51MP0003329_amyloid_beta_deposits1.63385472
52MP0002064_seizures1.61207313
53MP0002723_abnormal_immune_serum1.59529117
54MP0001800_abnormal_humoral_immune1.59443153
55MP0002063_abnormal_learning/memory/cond1.58027377
56MP0002420_abnormal_adaptive_immunity1.56040024
57MP0003075_altered_response_to1.53381644
58MP0001819_abnormal_immune_cell1.53032125
59MP0002249_abnormal_larynx_morphology1.51772099
60MP0005075_abnormal_melanosome_morpholog1.51410581
61MP0002419_abnormal_innate_immunity1.50645535
62MP0003635_abnormal_synaptic_transmissio1.48162870
63MP0005451_abnormal_body_composition1.45959219
64MP0000358_abnormal_cell_content/1.45142931
65MP0002452_abnormal_antigen_presenting1.43853050
66MP0001529_abnormal_vocalization1.41791777
67MP0003283_abnormal_digestive_organ1.38777998
68MP0001790_abnormal_immune_system1.38680240
69MP0005387_immune_system_phenotype1.38680240
70MP0002282_abnormal_trachea_morphology1.36385026
71MP0000639_abnormal_adrenal_gland1.35865012
72MP0002733_abnormal_thermal_nociception1.35347142
73MP0005646_abnormal_pituitary_gland1.34812074
74MP0002398_abnormal_bone_marrow1.33910438
75MP0001970_abnormal_pain_threshold1.28870771
76MP0009764_decreased_sensitivity_to1.27991737
77MP0001533_abnormal_skeleton_physiology1.26253161
78MP0008875_abnormal_xenobiotic_pharmacok1.25503129
79MP0000716_abnormal_immune_system1.24683237
80MP0002722_abnormal_immune_system1.22879097
81MP0003300_gastrointestinal_ulcer1.20729361
82MP0002254_reproductive_system_inflammat1.18418482
83MP0000343_altered_response_to1.18049841
84MP0000955_abnormal_spinal_cord1.17733145
85MP0002269_muscular_atrophy1.17610558
86MP0001845_abnormal_inflammatory_respons1.17562030
87MP0000685_abnormal_immune_system1.15896405
88MP0002429_abnormal_blood_cell1.15461747
89MP0001697_abnormal_embryo_size1.13656299
90MP0000465_gastrointestinal_hemorrhage1.13583831
91MP0003111_abnormal_nucleus_morphology1.12821178
92MP0000689_abnormal_spleen_morphology1.10284510
93MP0008469_abnormal_protein_level1.10248318
94MP0000703_abnormal_thymus_morphology1.10174411
95MP0005266_abnormal_metabolism1.09509980
96MP0003186_abnormal_redox_activity1.07634262
97MP0002751_abnormal_autonomic_nervous1.07387345
98MP0001905_abnormal_dopamine_level1.07151046
99MP0004510_myositis1.06463776
100MP0002272_abnormal_nervous_system1.06002692
101MP0002405_respiratory_system_inflammati1.04501030
102MP0001986_abnormal_taste_sensitivity1.04248784
103MP0005408_hypopigmentation1.03975665
104MP0009745_abnormal_behavioral_response1.03429662
105MP0004811_abnormal_neuron_physiology1.03329069
106MP0001293_anophthalmia1.02994987
107MP0002084_abnormal_developmental_patter1.01923273
108MP0003866_abnormal_defecation1.01458207
109MP0005253_abnormal_eye_physiology1.01337561
110MP0003137_abnormal_impulse_conducting1.00146059
111MP0005167_abnormal_blood-brain_barrier0.99376737
112MP0002736_abnormal_nociception_after0.99156706
113MP0000778_abnormal_nervous_system0.99013684
114MP0003077_abnormal_cell_cycle0.97678712
115MP0002138_abnormal_hepatobiliary_system0.97577327
116MP0003718_maternal_effect0.95536076
117MP0002102_abnormal_ear_morphology0.95470891
118MP0008874_decreased_physiological_sensi0.94187462
119MP0001968_abnormal_touch/_nociception0.93864210
120MP0006292_abnormal_olfactory_placode0.92269372
121MP0002085_abnormal_embryonic_tissue0.91543834
122MP0009763_increased_sensitivity_to0.91435452
123MP0005166_decreased_susceptibility_to0.91387252
124MP0000049_abnormal_middle_ear0.88754307
125MP0000747_muscle_weakness0.88418836
126MP0000681_abnormal_thyroid_gland0.87564742
127MP0000462_abnormal_digestive_system0.87188815
128MP0005535_abnormal_body_temperature0.86648868
129MP0002066_abnormal_motor_capabilities/c0.86004549
130MP0008569_lethality_at_weaning0.85857001
131MP0002184_abnormal_innervation0.85041587
132MP0002086_abnormal_extraembryonic_tissu0.84814577
133MP0000470_abnormal_stomach_morphology0.84133344
134MP0003693_abnormal_embryo_hatching0.83924997
135MP0000858_altered_metastatic_potential0.83583070
136MP0003656_abnormal_erythrocyte_physiolo0.83521642
137MP0001873_stomach_inflammation0.83328623
138MP0001340_abnormal_eyelid_morphology0.83069145
139MP0002067_abnormal_sensory_capabilities0.82983018
140MP0005423_abnormal_somatic_nervous0.82189337
141MP0005058_abnormal_lysosome_morphology0.82104622
142MP0002332_abnormal_exercise_endurance0.81708646
143MP0002114_abnormal_axial_skeleton0.81657670
144MP0000490_abnormal_crypts_of0.81550710
145MP0002909_abnormal_adrenal_gland0.80760187
146MP0008007_abnormal_cellular_replicative0.80002772
147MP0002111_abnormal_tail_morphology0.78484562
148MP0000750_abnormal_muscle_regeneration0.77148081
149MP0002882_abnormal_neuron_morphology0.76657247
150MP0006036_abnormal_mitochondrial_physio0.76550836
151MP0002932_abnormal_joint_morphology0.76255687
152MP0002822_catalepsy0.75730326
153MP0000579_abnormal_nail_morphology0.74990363
154MP0003943_abnormal_hepatobiliary_system0.74580680
155MP0000371_diluted_coat_color0.74534338
156MP0004947_skin_inflammation0.74049662
157MP0004924_abnormal_behavior0.73658138
158MP0005386_behavior/neurological_phenoty0.73658138
159MP0001186_pigmentation_phenotype0.73260424
160MP0001853_heart_inflammation0.72926897
161MP0001502_abnormal_circadian_rhythm0.72913452
162MP0004197_abnormal_fetal_growth/weight/0.72709755
163MP0000013_abnormal_adipose_tissue0.72632042
164MP0002693_abnormal_pancreas_physiology0.72356968
165MP0002152_abnormal_brain_morphology0.72170111
166MP0002075_abnormal_coat/hair_pigmentati0.72135198
167MP0008873_increased_physiological_sensi0.71279800
168MP0003122_maternal_imprinting0.70798900
169MP0008004_abnormal_stomach_pH0.70775168
170MP0000350_abnormal_cell_proliferation0.70101857
171MP0004134_abnormal_chest_morphology0.69460851
172MP0010768_mortality/aging0.69272838
173MP0001764_abnormal_homeostasis0.68845011
174MP0002970_abnormal_white_adipose0.68102956
175MP0002132_abnormal_respiratory_system0.67773375
176MP0002080_prenatal_lethality0.67159771
177MP0000631_abnormal_neuroendocrine_gland0.66644174
178MP0002163_abnormal_gland_morphology0.66381536

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.58840060
2Increased IgM level (HP:0003496)4.51408684
3Rib fusion (HP:0000902)4.50431025
4Concave nail (HP:0001598)4.37572951
5Rectal fistula (HP:0100590)4.15002785
6Rectovaginal fistula (HP:0000143)4.15002785
7Poikiloderma (HP:0001029)4.12958190
8Tongue fasciculations (HP:0001308)3.99025826
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.83147508
10Facial hemangioma (HP:0000329)3.68647151
11Vaginal fistula (HP:0004320)3.61301055
12Intestinal fistula (HP:0100819)3.56648068
13Muscle fibrillation (HP:0010546)3.47620873
14Elevated erythrocyte sedimentation rate (HP:0003565)3.46393964
15Abnormality of glycolipid metabolism (HP:0010969)3.42454700
16Abnormality of liposaccharide metabolism (HP:0010968)3.42454700
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.42454700
18Increased muscle lipid content (HP:0009058)3.38186810
19Increased intramyocellular lipid droplets (HP:0012240)3.33872597
20Atonic seizures (HP:0010819)3.32618992
21Intestinal atresia (HP:0011100)3.30421135
22Increased cerebral lipofuscin (HP:0011813)3.28631365
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.19975549
24Pustule (HP:0200039)3.19142073
25Anteriorly placed anus (HP:0001545)3.16841275
26Petechiae (HP:0000967)3.12396238
27Orthostatic hypotension (HP:0001278)3.06678892
28Hepatic necrosis (HP:0002605)3.05800606
29Progressive neurologic deterioration (HP:0002344)3.00809566
30Broad alveolar ridges (HP:0000187)3.00400053
31IgM deficiency (HP:0002850)2.98944231
32Turricephaly (HP:0000262)2.94635847
33B lymphocytopenia (HP:0010976)2.94356226
34Diaphragmatic weakness (HP:0009113)2.93920186
35Male infertility (HP:0003251)2.92365143
36Ragged-red muscle fibers (HP:0003200)2.92264787
37Abnormality of the aortic arch (HP:0012303)2.92017653
38Dysautonomia (HP:0002459)2.89835467
39Mitochondrial inheritance (HP:0001427)2.89744019
40Abnormality of the labia minora (HP:0012880)2.87850317
41Retinal dysplasia (HP:0007973)2.87577504
42Epileptic encephalopathy (HP:0200134)2.87249791
43Stomatitis (HP:0010280)2.87142628
44Abnormal gallbladder physiology (HP:0012438)2.86321489
45Cholecystitis (HP:0001082)2.86321489
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86138474
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86138474
48Aplasia/hypoplasia of the humerus (HP:0006507)2.85992552
49Delusions (HP:0000746)2.85866738
50Narrow nasal bridge (HP:0000446)2.83127813
51Short humerus (HP:0005792)2.79381271
52Coronal craniosynostosis (HP:0004440)2.77466432
53CNS hypomyelination (HP:0003429)2.77126005
54Abnormality of male internal genitalia (HP:0000022)2.76262575
55Abnormality of B cell number (HP:0010975)2.74198733
56Congenital hip dislocation (HP:0001374)2.71957173
57Gait imbalance (HP:0002141)2.71428531
58Vertebral hypoplasia (HP:0008417)2.66998563
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.66998563
60Congenital primary aphakia (HP:0007707)2.66825753
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66597785
62Mucopolysacchariduria (HP:0008155)2.65684867
63Urinary glycosaminoglycan excretion (HP:0003541)2.65684867
64Alacrima (HP:0000522)2.65366119
65Nephrogenic diabetes insipidus (HP:0009806)2.64228485
66Absent radius (HP:0003974)2.63515146
67Pheochromocytoma (HP:0002666)2.63430665
68Poor suck (HP:0002033)2.63424578
69Large for gestational age (HP:0001520)2.63289269
70Alopecia of scalp (HP:0002293)2.62184750
71Emotional lability (HP:0000712)2.61174782
72Clumsiness (HP:0002312)2.59247662
73Absent thumb (HP:0009777)2.58877039
74Increased CSF lactate (HP:0002490)2.58327822
75Type 2 muscle fiber atrophy (HP:0003554)2.57528684
76Premature skin wrinkling (HP:0100678)2.57024733
77Muscle fiber atrophy (HP:0100295)2.56744343
78Hypokinesia (HP:0002375)2.54634529
79Visual hallucinations (HP:0002367)2.53277157
80Aplasia involving forearm bones (HP:0009822)2.52884132
81Absent forearm bone (HP:0003953)2.52884132
82Microvesicular hepatic steatosis (HP:0001414)2.51613339
83Premature graying of hair (HP:0002216)2.47845118
84Cerebral hypomyelination (HP:0006808)2.47158165
85Abnormal respiratory epithelium morphology (HP:0012253)2.45515455
86Abnormal respiratory motile cilium morphology (HP:0005938)2.45515455
873-Methylglutaconic aciduria (HP:0003535)2.44615383
88Growth hormone excess (HP:0000845)2.42695314
89Exertional dyspnea (HP:0002875)2.42240171
90Hypochromic microcytic anemia (HP:0004840)2.39601107
91Short chin (HP:0000331)2.39124734
92Neuroendocrine neoplasm (HP:0100634)2.39037253
93Patellar aplasia (HP:0006443)2.38447430
94Opisthotonus (HP:0002179)2.37190211
95Pancreatic islet-cell hyperplasia (HP:0004510)2.36507804
96Vacuolated lymphocytes (HP:0001922)2.36349910
97Choanal stenosis (HP:0000452)2.34646970
98Bifid uvula (HP:0000193)2.33217158
99Joint stiffness (HP:0001387)2.32854107
100Squamous cell carcinoma (HP:0002860)2.31294512
101Supranuclear gaze palsy (HP:0000605)2.30865833
102Mediastinal lymphadenopathy (HP:0100721)2.30583407
103Medial flaring of the eyebrow (HP:0010747)2.29570141
104Ulnar bowing (HP:0003031)2.29545422
105Unsteady gait (HP:0002317)2.28899544
106Abnormality of polysaccharide metabolism (HP:0011012)2.27823027
107Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27823027
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27823027
109Loss of speech (HP:0002371)2.26647545
110Neoplasm of head and neck (HP:0012288)2.26279865
111Esophageal neoplasm (HP:0100751)2.26279865
112Dysostosis multiplex (HP:0000943)2.26002427
113Focal motor seizures (HP:0011153)2.24850465
114Hepatosplenomegaly (HP:0001433)2.24714438
115Abnormality of T cell physiology (HP:0011840)2.23426148
116Redundant skin (HP:0001582)2.23143884
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20949369
118Hamartoma (HP:0010566)2.20292467
119Acute necrotizing encephalopathy (HP:0006965)2.19905900
120Febrile seizures (HP:0002373)2.19157619
121Aplasia/Hypoplasia of the patella (HP:0006498)2.18677267
122Increased serum lactate (HP:0002151)2.18356264
123Decreased lacrimation (HP:0000633)2.17739738
124Abnormal mitochondria in muscle tissue (HP:0008316)2.15694987
125Hypotelorism (HP:0000601)2.15623640
126Recurrent abscess formation (HP:0002722)2.14831493
127Abnormality of the heme biosynthetic pathway (HP:0010472)2.14762026
128Abnormal hemoglobin (HP:0011902)2.13804699
129Bulbar palsy (HP:0001283)2.13711093
130Purpura (HP:0000979)2.13161895
131Progressive microcephaly (HP:0000253)2.12441717
132Acute lymphatic leukemia (HP:0006721)2.12420247
133Acute encephalopathy (HP:0006846)2.11716829
134Abnormality of macrophages (HP:0004311)2.11546888
135Ankle clonus (HP:0011448)2.11278111
136Myokymia (HP:0002411)2.09403971
137Poor coordination (HP:0002370)2.08725070
138Aplasia/hypoplasia of the uterus (HP:0008684)2.08685703
139Diminished movement (HP:0002374)2.08459608
140Lactic acidosis (HP:0003128)2.07903121
141Testicular atrophy (HP:0000029)2.06797040
142Spinal muscular atrophy (HP:0007269)2.05757357
143Gastrointestinal stroma tumor (HP:0100723)2.03682783
144CNS demyelination (HP:0007305)2.03682166
145Capillary hemangiomas (HP:0005306)2.03574516
146Autoamputation (HP:0001218)2.02081798
147Severe combined immunodeficiency (HP:0004430)2.01621712
148Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01341234
149Recurrent bacterial skin infections (HP:0005406)2.00449834
150Renal Fanconi syndrome (HP:0001994)2.00338722
151Hepatocellular necrosis (HP:0001404)1.99274191
152Exercise intolerance (HP:0003546)1.98538174
153Absence seizures (HP:0002121)1.98506378
154Degeneration of anterior horn cells (HP:0002398)1.98294631
155Abnormality of the anterior horn cell (HP:0006802)1.98294631
156Amelogenesis imperfecta (HP:0000705)1.98118945
157Hand muscle atrophy (HP:0009130)1.97694839
158Selective tooth agenesis (HP:0001592)1.97205328
159Myoclonus (HP:0001336)1.97082906
160Fetal akinesia sequence (HP:0001989)1.96150022
161IgG deficiency (HP:0004315)1.95696483
162Prolonged neonatal jaundice (HP:0006579)1.95275087
163Obstructive lung disease (HP:0006536)1.95201543
164Chronic obstructive pulmonary disease (HP:0006510)1.95201543
165Thickened helices (HP:0000391)1.93853798
166Hypoplasia of the radius (HP:0002984)1.92349044
167Acute hepatic failure (HP:0006554)1.92101070
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91671861
169Cerebral palsy (HP:0100021)1.91082298
170Eczematoid dermatitis (HP:0000976)1.90786481
171Respiratory failure (HP:0002878)1.88864589
172Stridor (HP:0010307)1.88670898
173Albinism (HP:0001022)1.86516368
174Cholelithiasis (HP:0001081)1.86206996
175Progressive macrocephaly (HP:0004481)1.85215592
176Recurrent fungal infections (HP:0002841)1.84953563
177Posterior subcapsular cataract (HP:0007787)1.84705586
178Myositis (HP:0100614)1.83215995
179Severe visual impairment (HP:0001141)1.81618752
180J-shaped sella turcica (HP:0002680)1.80902851
181Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80259742
182Abnormality of the gallbladder (HP:0005264)1.80142189
183Hypertensive crisis (HP:0100735)1.79755355
184Distal upper limb amyotrophy (HP:0007149)1.79537871
185Upper limb amyotrophy (HP:0009129)1.79537871
186Dicarboxylic aciduria (HP:0003215)1.78815124
187Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78815124
188Prolonged bleeding time (HP:0003010)1.78445364
189Personality changes (HP:0000751)1.78405904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.80181454
2MAP3K64.62319135
3MAPK154.09133184
4DDR24.04398984
5DAPK13.57906129
6NME23.55980243
7BCKDK3.45788329
8MAP3K113.45726183
9PINK13.10915522
10MATK2.72497204
11PIM22.68920678
12UHMK12.63316213
13FGR2.51659475
14TESK12.51516461
15AKT32.50790613
16YES12.47397922
17VRK22.39997375
18TYRO32.39660437
19MAP4K12.37646538
20ERN12.25095026
21IRAK32.03541689
22CDK191.91792162
23CSNK1G31.82634730
24CASK1.78926158
25PRPF4B1.78807422
26MAP3K121.75229641
27TAOK11.72585768
28LIMK11.71768097
29PRKD21.67136023
30MAP2K31.63507835
31PRKD31.63230927
32KDR1.56747755
33RIPK41.56552861
34SMG11.49526830
35MAPKAPK31.47420011
36CSNK1A1L1.45605948
37TBK11.44849317
38ACVR1B1.44093954
39MAP4K21.37837939
40BMX1.36562704
41CDK71.34340019
42MAP2K71.33921146
43CSK1.32902258
44BUB11.28597380
45PRKCI1.28203774
46ZAP701.27527176
47RPS6KC11.25302415
48RPS6KL11.25302415
49CSNK1G21.23104751
50GRK61.17797753
51PHKG21.16991664
52PHKG11.16991664
53TRIB31.15198188
54DYRK1B1.12021276
55ITK1.11438072
56RPS6KA61.08659070
57PDGFRA1.08592316
58LATS21.07470448
59EPHA41.06754653
60FES1.05965048
61TRIM281.04735754
62TXK1.00902348
63TYK21.00446017
64SIK31.00303386
65SYK0.98066681
66RAF10.96696268
67ABL20.95426896
68PAK40.94967315
69KIT0.94793288
70STK160.91439369
71MAP3K50.90907627
72CDK80.88635218
73PIM10.86737846
74CDC42BPA0.85881884
75EIF2AK10.85479735
76TEC0.84804030
77DYRK20.83307116
78CCNB10.80986149
79BTK0.80341313
80TAOK20.79573240
81IRAK40.78339660
82CHEK20.75464843
83BLK0.75408272
84EPHB10.74886709
85MAP3K130.74235827
86CAMK2B0.74175863
87PLK10.73282213
88SRPK10.71119798
89ILK0.70986733
90MUSK0.70910146
91MAP3K40.70398765
92DAPK30.69522570
93GRK50.68463571
94SIK10.68375161
95TRPM70.67030695
96WEE10.65357610
97MAP3K10.65206892
98ERBB30.65203932
99MAPK110.65058448
100MAP2K60.64705411
101CAMKK20.63723702
102DYRK30.62817437
103ARAF0.62635529
104NTRK20.62035696
105LCK0.62022511
106GSK3A0.61544854
107HCK0.58874899
108TSSK60.58732186
109AURKA0.58688470
110MAP3K30.58595338
111JAK30.58304989
112CAMK2A0.55883626
113MAP3K90.54017491
114CDK180.53918210
115RPS6KB10.53759486
116PTK2B0.52282991
117PRKCH0.52144714
118CDK11A0.50152691
119STK380.50044260
120CDK150.49506946
121CAMK2G0.49227942
122BRAF0.49164192
123NEK10.49036020
124TNK20.48850450
125LMTK20.47212331
126NTRK30.47162995
127CSNK2A10.47108731
128RPS6KA10.46570954
129CAMKK10.45535774
130MAPK40.45214215
131VRK10.44127220
132IKBKB0.42472821
133KSR20.41242615
134SIK20.39843718
135CDK140.39047686
136BRSK10.38945789
137ATR0.38883006
138IRAK20.38242017
139ZAK0.36866612
140PRKCQ0.36855736
141MINK10.36552210
142TESK20.36479115
143IKBKE0.36189635
144NME10.35415975
145PRKAA10.34998574
146MARK20.34431420
147LYN0.33615587
148MAP2K40.33536822
149MAPK130.33196780
150MAPK120.33149206
151CDK60.33114967
152CDK50.32595389
153MARK10.31988254
154CDK20.31606494
155MAPK30.30450176
156CSNK2A20.29722131
157HIPK20.28361630
158BRSK20.25772771
159CAMK2D0.23237526
160PAK60.21616701
161PRKCD0.21128644
162TNIK0.20908498
163CSNK1G10.20812612
164PRKCG0.20363200
165PAK10.19434959
166PLK20.18939050
167MAPK100.18903287
168DAPK20.18257020

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.89522376
2Base excision repair_Homo sapiens_hsa034104.47940381
3DNA replication_Homo sapiens_hsa030303.93836862
4Fatty acid biosynthesis_Homo sapiens_hsa000613.92284132
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.92523100
6Nucleotide excision repair_Homo sapiens_hsa034202.69678565
7Proteasome_Homo sapiens_hsa030502.66100377
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.46366575
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26091426
10Spliceosome_Homo sapiens_hsa030402.22777225
11Other glycan degradation_Homo sapiens_hsa005112.18343353
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.15935139
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12341680
14Oxidative phosphorylation_Homo sapiens_hsa001902.08769836
15Lysosome_Homo sapiens_hsa041421.96669696
16Homologous recombination_Homo sapiens_hsa034401.95725877
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88547782
18Circadian rhythm_Homo sapiens_hsa047101.84571201
19Ribosome_Homo sapiens_hsa030101.81830065
20RNA transport_Homo sapiens_hsa030131.81109486
21RNA polymerase_Homo sapiens_hsa030201.80825223
22Parkinsons disease_Homo sapiens_hsa050121.76263414
23Synaptic vesicle cycle_Homo sapiens_hsa047211.68802591
24Biosynthesis of amino acids_Homo sapiens_hsa012301.67338457
25Allograft rejection_Homo sapiens_hsa053301.66059268
26mRNA surveillance pathway_Homo sapiens_hsa030151.64902070
27Autoimmune thyroid disease_Homo sapiens_hsa053201.63091856
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58592047
29Pentose phosphate pathway_Homo sapiens_hsa000301.58501952
30Sulfur relay system_Homo sapiens_hsa041221.54103761
31Nicotine addiction_Homo sapiens_hsa050331.49676585
32Huntingtons disease_Homo sapiens_hsa050161.43621122
33Collecting duct acid secretion_Homo sapiens_hsa049661.41422231
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39890413
35Fanconi anemia pathway_Homo sapiens_hsa034601.32196302
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32027749
37Arginine and proline metabolism_Homo sapiens_hsa003301.31653609
38Graft-versus-host disease_Homo sapiens_hsa053321.28924394
39Type I diabetes mellitus_Homo sapiens_hsa049401.28907171
40T cell receptor signaling pathway_Homo sapiens_hsa046601.27924811
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20457444
42Hematopoietic cell lineage_Homo sapiens_hsa046401.20409377
43Regulation of autophagy_Homo sapiens_hsa041401.18954898
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.18196445
45Hedgehog signaling pathway_Homo sapiens_hsa043401.16092858
46Fructose and mannose metabolism_Homo sapiens_hsa000511.14358517
47Rheumatoid arthritis_Homo sapiens_hsa053231.14318640
48Vitamin B6 metabolism_Homo sapiens_hsa007501.13383027
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13183380
50Folate biosynthesis_Homo sapiens_hsa007901.12722464
51Pyrimidine metabolism_Homo sapiens_hsa002401.06385210
52Phagosome_Homo sapiens_hsa041451.05530166
53Oocyte meiosis_Homo sapiens_hsa041141.05116634
54Hippo signaling pathway_Homo sapiens_hsa043901.04527517
55Cell cycle_Homo sapiens_hsa041101.00740409
56mTOR signaling pathway_Homo sapiens_hsa041501.00130281
57Alzheimers disease_Homo sapiens_hsa050100.99101955
58Endocytosis_Homo sapiens_hsa041440.96708705
59Tuberculosis_Homo sapiens_hsa051520.96601706
60GABAergic synapse_Homo sapiens_hsa047270.94755680
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92976586
62Osteoclast differentiation_Homo sapiens_hsa043800.92405613
63Notch signaling pathway_Homo sapiens_hsa043300.91185746
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89353339
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88750495
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84894524
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84426746
68Salmonella infection_Homo sapiens_hsa051320.84328147
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84053331
70Shigellosis_Homo sapiens_hsa051310.83949433
71Wnt signaling pathway_Homo sapiens_hsa043100.82876036
72Fatty acid metabolism_Homo sapiens_hsa012120.82731431
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82299228
74p53 signaling pathway_Homo sapiens_hsa041150.79263492
75Vibrio cholerae infection_Homo sapiens_hsa051100.78646842
76RNA degradation_Homo sapiens_hsa030180.77201383
77Basal transcription factors_Homo sapiens_hsa030220.73714403
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71182785
79Gap junction_Homo sapiens_hsa045400.70753443
80Viral myocarditis_Homo sapiens_hsa054160.70635111
81Asthma_Homo sapiens_hsa053100.70308261
82Cardiac muscle contraction_Homo sapiens_hsa042600.69506679
83Galactose metabolism_Homo sapiens_hsa000520.68350098
84Bladder cancer_Homo sapiens_hsa052190.68271797
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67713106
86Colorectal cancer_Homo sapiens_hsa052100.67583261
87N-Glycan biosynthesis_Homo sapiens_hsa005100.67519272
88Peroxisome_Homo sapiens_hsa041460.66897549
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.66239475
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65012648
91Acute myeloid leukemia_Homo sapiens_hsa052210.64065358
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63968720
93Herpes simplex infection_Homo sapiens_hsa051680.60683054
94Morphine addiction_Homo sapiens_hsa050320.59529179
95Fatty acid elongation_Homo sapiens_hsa000620.59259188
96Apoptosis_Homo sapiens_hsa042100.59164256
97Olfactory transduction_Homo sapiens_hsa047400.59042841
98Antigen processing and presentation_Homo sapiens_hsa046120.58489437
99Sulfur metabolism_Homo sapiens_hsa009200.58380492
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58068036
101Amphetamine addiction_Homo sapiens_hsa050310.57676620
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57264568
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56970411
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55910472
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54445814
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54126664
107Dopaminergic synapse_Homo sapiens_hsa047280.52672823
108Prion diseases_Homo sapiens_hsa050200.52671183
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.51981768
110ErbB signaling pathway_Homo sapiens_hsa040120.50815200
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.50806261
112Long-term depression_Homo sapiens_hsa047300.48827501
113Measles_Homo sapiens_hsa051620.47688061
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47595396
115Purine metabolism_Homo sapiens_hsa002300.47379148
116TGF-beta signaling pathway_Homo sapiens_hsa043500.47228325
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47021167
118Leishmaniasis_Homo sapiens_hsa051400.46733921
119VEGF signaling pathway_Homo sapiens_hsa043700.45493878
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45238033
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44855229
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.44537604
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43356886
124Protein export_Homo sapiens_hsa030600.43254851
125Basal cell carcinoma_Homo sapiens_hsa052170.42011053
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41746817
127Primary immunodeficiency_Homo sapiens_hsa053400.40790999
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.39875162
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38740053
130Glutathione metabolism_Homo sapiens_hsa004800.38433574
131Hepatitis C_Homo sapiens_hsa051600.37077237
132Epstein-Barr virus infection_Homo sapiens_hsa051690.37025170
133Metabolic pathways_Homo sapiens_hsa011000.32888515
134Hepatitis B_Homo sapiens_hsa051610.32770618
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32633290
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31466490
137Glutamatergic synapse_Homo sapiens_hsa047240.30464834
138Steroid biosynthesis_Homo sapiens_hsa001000.29856404
139Thyroid cancer_Homo sapiens_hsa052160.29855545
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.29695583
141Carbon metabolism_Homo sapiens_hsa012000.29643271
142Chemokine signaling pathway_Homo sapiens_hsa040620.29081669
143Long-term potentiation_Homo sapiens_hsa047200.28593621
144Pyruvate metabolism_Homo sapiens_hsa006200.28289066
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27320207
146Taste transduction_Homo sapiens_hsa047420.27106573
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26636423
148Circadian entrainment_Homo sapiens_hsa047130.25895387
149Serotonergic synapse_Homo sapiens_hsa047260.25624879
150Adherens junction_Homo sapiens_hsa045200.25596353
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23110919
152MAPK signaling pathway_Homo sapiens_hsa040100.22830593
153Insulin signaling pathway_Homo sapiens_hsa049100.19398640
154Phototransduction_Homo sapiens_hsa047440.18226788
155Legionellosis_Homo sapiens_hsa051340.16973149

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