TMEM225

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.91180802
2axonemal dynein complex assembly (GO:0070286)9.82884152
3reproduction (GO:0000003)9.71116323
4epithelial cilium movement (GO:0003351)9.67716468
5motile cilium assembly (GO:0044458)9.66951489
6spermatid development (GO:0007286)9.56155157
7regulation of cilium movement (GO:0003352)7.88349179
8cilium movement (GO:0003341)7.85221615
9single fertilization (GO:0007338)7.54256061
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.40095888
11piRNA metabolic process (GO:0034587)7.15611629
12male meiosis (GO:0007140)7.15457559
13synaptonemal complex organization (GO:0070193)7.10745624
14synaptonemal complex assembly (GO:0007130)7.01216312
15sperm capacitation (GO:0048240)6.94714204
16negative regulation of inclusion body assembly (GO:0090084)6.48745093
17spermatogenesis (GO:0007283)6.48369245
18male gamete generation (GO:0048232)6.46394154
19microtubule depolymerization (GO:0007019)6.39766211
20fertilization (GO:0009566)6.35433896
21organic cation transport (GO:0015695)6.19804544
22gamete generation (GO:0007276)5.94272064
23regulation of inclusion body assembly (GO:0090083)5.55532938
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.35012353
25calcium ion-dependent exocytosis (GO:0017156)5.34205024
26germ cell development (GO:0007281)5.33304030
27cell recognition (GO:0008037)5.08221780
28seminiferous tubule development (GO:0072520)5.02957135
29ventricular system development (GO:0021591)4.92621504
30chromosome organization involved in meiosis (GO:0070192)4.89994451
31spermatid nucleus differentiation (GO:0007289)4.88656419
32male meiosis I (GO:0007141)4.83551764
33chromosome condensation (GO:0030261)4.78900980
34glycerol ether metabolic process (GO:0006662)4.70385712
35regulation of microtubule-based movement (GO:0060632)4.67551922
36multicellular organismal reproductive process (GO:0048609)4.66078447
37DNA methylation involved in gamete generation (GO:0043046)4.63242033
38DNA packaging (GO:0006323)4.61195243
39microtubule severing (GO:0051013)4.40054754
40meiotic nuclear division (GO:0007126)4.37258219
41ether metabolic process (GO:0018904)4.34243329
42sequestering of actin monomers (GO:0042989)4.11072965
43chaperone-mediated protein complex assembly (GO:0051131)4.01199723
44left/right pattern formation (GO:0060972)4.00709174
45sexual reproduction (GO:0019953)3.86814079
46meiosis I (GO:0007127)3.83795010
47multicellular organismal development (GO:0007275)3.81996736
48single strand break repair (GO:0000012)3.76406073
49genitalia morphogenesis (GO:0035112)3.61713046
50monoubiquitinated protein deubiquitination (GO:0035520)3.60207211
51negative regulation of organelle assembly (GO:1902116)3.59208152
52meiotic cell cycle (GO:0051321)3.44955691
53protein K11-linked deubiquitination (GO:0035871)3.40553668
54nuclear pore complex assembly (GO:0051292)3.32269611
55GTP biosynthetic process (GO:0006183)3.30620670
56protein localization to cilium (GO:0061512)3.29067224
57microtubule polymerization or depolymerization (GO:0031109)3.27091983
58nucleoside diphosphate phosphorylation (GO:0006165)3.26991539
59RNA localization (GO:0006403)3.18549400
60protein polyglutamylation (GO:0018095)3.11897227
61alditol metabolic process (GO:0019400)3.11507553
62nucleus organization (GO:0006997)3.10377630
63regulation of spindle checkpoint (GO:0090231)3.05078132
64carnitine transport (GO:0015879)3.01664982
65amino-acid betaine transport (GO:0015838)3.01664982
66polyol catabolic process (GO:0046174)2.98771791
67glycolytic process (GO:0006096)2.98204612
68synapsis (GO:0007129)2.98029944
69protein refolding (GO:0042026)2.97288229
70mitotic sister chromatid cohesion (GO:0007064)2.97004589
71UTP biosynthetic process (GO:0006228)2.94734353
72lactate metabolic process (GO:0006089)2.90597163
73carnitine transmembrane transport (GO:1902603)2.86306871
74meiotic cell cycle process (GO:1903046)2.82850318
75centriole assembly (GO:0098534)2.82632968
76cilium organization (GO:0044782)2.80680300
77positive regulation of macrophage activation (GO:0043032)2.73861822
78microtubule-based movement (GO:0007018)2.73617330
79interferon-gamma secretion (GO:0072643)2.73524734
80intraciliary transport (GO:0042073)2.73450201
81glycerol metabolic process (GO:0006071)2.71580441
82cilium assembly (GO:0042384)2.69691857
83cellular component assembly involved in morphogenesis (GO:0010927)2.69513805
84UTP metabolic process (GO:0046051)2.65636447
85axoneme assembly (GO:0035082)2.64304777
86regulation of cilium assembly (GO:1902017)2.62570211
87nuclear pore organization (GO:0006999)2.59537185
88cilium morphogenesis (GO:0060271)2.59298660
89pore complex assembly (GO:0046931)2.55858324
90fusion of sperm to egg plasma membrane (GO:0007342)14.2837957
91cell wall macromolecule catabolic process (GO:0016998)13.8835611
92cell wall macromolecule metabolic process (GO:0044036)13.8835611
93sperm motility (GO:0030317)13.4905135
94acrosome assembly (GO:0001675)12.0103190
95sperm-egg recognition (GO:0035036)11.7548734
96acrosome reaction (GO:0007340)11.5877803
97multicellular organism reproduction (GO:0032504)11.3805982
98plasma membrane fusion (GO:0045026)10.8951163
99binding of sperm to zona pellucida (GO:0007339)10.6298243
100cell-cell recognition (GO:0009988)10.5273057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.90168943
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20417491
3EZH2_22144423_ChIP-Seq_EOC_Human3.95837189
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.05056940
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94780067
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90136236
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69332688
8VDR_22108803_ChIP-Seq_LS180_Human2.27286939
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27196260
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.25377326
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.12893038
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01783061
13ZNF274_21170338_ChIP-Seq_K562_Hela1.95810062
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94676742
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.86449286
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85432028
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80832207
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77441024
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72805053
20STAT1_17558387_ChIP-Seq_HELA_Human1.72149701
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66588613
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61705411
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61511828
24KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61273872
25MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60291734
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.58718632
27* GATA3_21867929_ChIP-Seq_CD8_Mouse1.56981612
28GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54899059
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53879495
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50811394
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.50323446
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50269243
33TAL1_26923725_Chip-Seq_HPCs_Mouse1.50214455
34KDM2B_26808549_Chip-Seq_REH_Human1.48050224
35CBP_20019798_ChIP-Seq_JUKART_Human1.41689252
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41689252
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.40375788
38LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35356838
39P53_21459846_ChIP-Seq_SAOS-2_Human1.33691294
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33552611
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30293564
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29091816
43GATA3_21867929_ChIP-Seq_TH1_Mouse1.29030775
44FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26401833
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25744966
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25618788
47SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.25492616
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22275248
49REST_21632747_ChIP-Seq_MESCs_Mouse1.21942135
50FLI1_21867929_ChIP-Seq_TH2_Mouse1.20424547
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.17837672
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16600443
53GF1_26923725_Chip-Seq_HPCs_Mouse1.15666555
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.14121222
55RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13901380
56CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13696022
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12655202
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12012483
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10209336
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.10188452
61CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07618400
62RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06542863
63SPI1_26923725_Chip-Seq_HPCs_Mouse1.06494836
64P53_22387025_ChIP-Seq_ESCs_Mouse1.05886631
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05585074
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05288957
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03957657
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03408215
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.02990435
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.02954074
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02314721
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.02112686
73ERG_20517297_ChIP-Seq_VCAP_Human1.01407079
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00355152
75KLF4_18555785_Chip-Seq_ESCs_Mouse0.99958523
76P300_18555785_Chip-Seq_ESCs_Mouse0.99293443
77RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99273963
78RARA_24833708_ChIP-Seq_LIVER_Mouse0.98813779
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97972864
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97594615
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97594615
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97122317
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96949408
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96341320
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.96117402
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95526152
87ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95186279
88FLI1_21867929_ChIP-Seq_CD8_Mouse0.93345965
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92875438
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92769291
91MYC_27129775_Chip-Seq_CORNEA_Mouse0.92425489
92* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92011385
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91066045
94STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90499126
95RNF2_27304074_Chip-Seq_NSC_Mouse0.89920564
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89274435
97NFYB_21822215_ChIP-Seq_K562_Human0.88362854
98TAF15_26573619_Chip-Seq_HEK293_Human0.88264703
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88148885
100PU1_27457419_Chip-Seq_LIVER_Mouse0.87834733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06728183
2MP0001929_abnormal_gametogenesis5.57571051
3MP0008877_abnormal_DNA_methylation4.29937475
4MP0002210_abnormal_sex_determination3.42552722
5MP0002161_abnormal_fertility/fecundity3.28822177
6MP0001145_abnormal_male_reproductive2.91043011
7MP0005670_abnormal_white_adipose2.62339333
8MP0000653_abnormal_sex_gland2.51851278
9MP0002653_abnormal_ependyma_morphology2.45680906
10MP0005410_abnormal_fertilization16.5105345
11MP0002160_abnormal_reproductive_system1.72712664
12MP0005623_abnormal_meninges_morphology1.34472367
13MP0003011_delayed_dark_adaptation1.31877241
14MP0003646_muscle_fatigue1.31812172
15MP0004233_abnormal_muscle_weight1.31076066
16MP0002282_abnormal_trachea_morphology1.08070304
17MP0001765_abnormal_ion_homeostasis1.04285087
18MP0008058_abnormal_DNA_repair1.00448642
19MP0005647_abnormal_sex_gland0.96343703
20MP0001984_abnormal_olfaction0.92462690
21MP0005389_reproductive_system_phenotype0.86688388
22MP0003111_abnormal_nucleus_morphology0.78795427
23MP0010094_abnormal_chromosome_stability0.77664534
24MP0002234_abnormal_pharynx_morphology0.77080539
25MP0008995_early_reproductive_senescence0.73072874
26MP0009046_muscle_twitch0.67642275
27MP0003115_abnormal_respiratory_system0.63595409
28MP0005377_hearing/vestibular/ear_phenot0.60909273
29MP0003878_abnormal_ear_physiology0.60909273
30MP0003950_abnormal_plasma_membrane0.59161427
31MP0005636_abnormal_mineral_homeostasis0.57802660
32MP0008057_abnormal_DNA_replication0.55287966
33MP0004133_heterotaxia0.52887921
34MP0001324_abnormal_eye_pigmentation0.52657622
35MP0001293_anophthalmia0.49991196
36MP0005397_hematopoietic_system_phenotyp0.46436373
37MP0001545_abnormal_hematopoietic_system0.46436373
38MP0000358_abnormal_cell_content/0.46218250
39MP0002736_abnormal_nociception_after0.46017119
40MP0000604_amyloidosis0.45895185
41MP0004036_abnormal_muscle_relaxation0.44570162
42MP0001764_abnormal_homeostasis0.44178895
43MP0003699_abnormal_female_reproductive0.44132937
44MP0009278_abnormal_bone_marrow0.42811616
45MP0005551_abnormal_eye_electrophysiolog0.42594959
46MP0002269_muscular_atrophy0.42213386
47MP0005253_abnormal_eye_physiology0.41685124
48MP0009115_abnormal_fat_cell0.41215195
49MP0010307_abnormal_tumor_latency0.39973337
50MP0002102_abnormal_ear_morphology0.39957355
51MP0006036_abnormal_mitochondrial_physio0.39189192
52MP0005666_abnormal_adipose_tissue0.36335997
53MP0001119_abnormal_female_reproductive0.35498221
54MP0002928_abnormal_bile_duct0.35345959
55MP0003786_premature_aging0.34537152
56MP0003329_amyloid_beta_deposits0.34448322
57MP0001730_embryonic_growth_arrest0.34005114
58MP0004019_abnormal_vitamin_homeostasis0.32316022
59MP0000569_abnormal_digit_pigmentation0.31710724
60MP0005391_vision/eye_phenotype0.30716655
61MP0002132_abnormal_respiratory_system0.30542020
62MP0002405_respiratory_system_inflammati0.26967707
63MP0003633_abnormal_nervous_system0.26612180
64MP0002139_abnormal_hepatobiliary_system0.24894754
65MP0002295_abnormal_pulmonary_circulatio0.23623007
66MP0001968_abnormal_touch/_nociception0.23613583
67MP0008007_abnormal_cellular_replicative0.23601151
68MP0001835_abnormal_antigen_presentation0.21919851
69MP0003948_abnormal_gas_homeostasis0.20988627
70MP0000313_abnormal_cell_death0.20300203
71MP0002971_abnormal_brown_adipose0.20216754
72MP0004811_abnormal_neuron_physiology0.19869910
73MP0006035_abnormal_mitochondrial_morpho0.18683296
74MP0002169_no_abnormal_phenotype0.18385374
75MP0003631_nervous_system_phenotype0.18339589
76MP0002873_normal_phenotype0.18269709
77MP0005319_abnormal_enzyme/_coenzyme0.18157863
78MP0003448_altered_tumor_morphology0.17279173
79MP0003861_abnormal_nervous_system0.17064702
80MP0001727_abnormal_embryo_implantation0.16972217
81MP0001661_extended_life_span0.16178744
82MP0004043_abnormal_pH_regulation0.15536265
83MP0002084_abnormal_developmental_patter0.15322561
84MP0003077_abnormal_cell_cycle0.15071874
85MP0002152_abnormal_brain_morphology0.14948434
86MP0009672_abnormal_birth_weight0.14766099
87MP0008875_abnormal_xenobiotic_pharmacok0.14708193
88MP0009785_altered_susceptibility_to0.14163691
89MP0002092_abnormal_eye_morphology0.14155794
90MP0005174_abnormal_tail_pigmentation0.13751456
91MP0000534_abnormal_ureter_morphology0.13726328
92MP0001849_ear_inflammation0.13298282
93MP0003942_abnormal_urinary_system0.12620363
94MP0002229_neurodegeneration0.12342034
95MP0000001_mammalian_phenotype0.12132084
96MP0002133_abnormal_respiratory_system0.11673497
97MP0005388_respiratory_system_phenotype0.11673497
98MP0004145_abnormal_muscle_electrophysio0.11609256
99MP0002148_abnormal_hypersensitivity_rea0.11407926
100MP0009703_decreased_birth_body0.11340215

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.54097393
2Abnormal respiratory epithelium morphology (HP:0012253)9.46326631
3Abnormal respiratory motile cilium morphology (HP:0005938)9.46326631
4Abnormal ciliary motility (HP:0012262)7.74916597
5Rhinitis (HP:0012384)7.53017665
6Chronic bronchitis (HP:0004469)7.36703490
7Infertility (HP:0000789)6.77980726
8Nasal polyposis (HP:0100582)6.46400970
9Abnormality of the nasal mucosa (HP:0000433)5.28778038
10Bronchitis (HP:0012387)4.46113745
11Bronchiectasis (HP:0002110)4.45213511
12Male infertility (HP:0003251)4.24671738
13Nephronophthisis (HP:0000090)3.96344676
14Recurrent sinusitis (HP:0011108)3.51589625
15Abnormal spermatogenesis (HP:0008669)3.41685472
16Recurrent otitis media (HP:0000403)3.16943865
17Abnormality of the renal medulla (HP:0100957)2.99924609
18Tubulointerstitial nephritis (HP:0001970)2.96724310
19Medial flaring of the eyebrow (HP:0010747)2.64840334
20Recurrent bronchitis (HP:0002837)2.52387249
21Tubular atrophy (HP:0000092)2.44008630
22Tubulointerstitial abnormality (HP:0001969)2.38340604
23Abnormality of midbrain morphology (HP:0002418)2.37878661
24Molar tooth sign on MRI (HP:0002419)2.37878661
25Gonadotropin excess (HP:0000837)2.36066952
26Impulsivity (HP:0100710)2.35849798
27Azoospermia (HP:0000027)2.34908850
28Dynein arm defect of respiratory motile cilia (HP:0012255)13.8017649
29Absent/shortened dynein arms (HP:0200106)13.8017649
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0986121
31Abnormal gallbladder physiology (HP:0012438)1.88425578
32Cholecystitis (HP:0001082)1.88425578
33Dyschromatopsia (HP:0007641)1.82338355
34Stage 5 chronic kidney disease (HP:0003774)1.80424711
35Tubulointerstitial fibrosis (HP:0005576)1.79260159
36Abnormality of the lower motor neuron (HP:0002366)1.78563729
37Abnormality of the renal cortex (HP:0011035)1.77445160
38Spastic tetraparesis (HP:0001285)1.74386442
39Heterotopia (HP:0002282)1.71641073
40Postaxial foot polydactyly (HP:0001830)1.69741534
41Decreased central vision (HP:0007663)1.67180276
42Congenital hepatic fibrosis (HP:0002612)1.61355404
43Congenital primary aphakia (HP:0007707)1.60240471
44Gait imbalance (HP:0002141)1.59810946
45Polydipsia (HP:0001959)1.59324014
46Abnormal drinking behavior (HP:0030082)1.59324014
47Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58364417
48Choroideremia (HP:0001139)1.57955218
49Abnormality of renal excretion (HP:0011036)1.53025133
50Fibular hypoplasia (HP:0003038)1.52756772
51Abnormality of permanent molar morphology (HP:0011071)1.51470470
52Abnormality of the dental root (HP:0006486)1.51470470
53Taurodontia (HP:0000679)1.51470470
54Aplasia/Hypoplasia of the lens (HP:0008063)1.51308442
55Hemorrhage of the eye (HP:0011885)1.50883276
56Fatigable weakness (HP:0003473)1.45071955
57Abnormality of the neuromuscular junction (HP:0003398)1.45071955
58Chronic sinusitis (HP:0011109)1.44480022
59Postaxial hand polydactyly (HP:0001162)1.42534228
60Short ribs (HP:0000773)1.42185019
61Supernumerary spleens (HP:0009799)1.41256443
62Absent frontal sinuses (HP:0002688)1.41234117
63Abnormality of molar (HP:0011077)1.40245557
64Abnormality of molar morphology (HP:0011070)1.40245557
65Abnormality of dentin (HP:0010299)1.38780619
66Abnormality of the dental pulp (HP:0006479)1.38493609
67Easy fatigability (HP:0003388)1.38484463
68Oculomotor apraxia (HP:0000657)1.38460952
69Amyotrophic lateral sclerosis (HP:0007354)1.36921509
70Nephrogenic diabetes insipidus (HP:0009806)1.35710772
71Facial cleft (HP:0002006)1.34614150
72Renal dysplasia (HP:0000110)1.32480209
73Asymmetric septal hypertrophy (HP:0001670)1.31081047
74Neurofibrillary tangles (HP:0002185)1.30602837
75Congenital malformation of the right heart (HP:0011723)1.30400776
76Double outlet right ventricle (HP:0001719)1.30400776
77Bell-shaped thorax (HP:0001591)1.29953855
78Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.27413591
79Impaired proprioception (HP:0010831)1.27274262
80Abnormal biliary tract physiology (HP:0012439)1.27024784
81Bile duct proliferation (HP:0001408)1.27024784
82Type 2 muscle fiber atrophy (HP:0003554)1.24757094
83Cystic liver disease (HP:0006706)1.22620390
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.22331039
85Absent epiphyses (HP:0010577)1.22331039
86Cerebellar dysplasia (HP:0007033)1.20902347
87Vaginal atresia (HP:0000148)1.20749337
88Retrobulbar optic neuritis (HP:0100654)1.19593832
89Optic neuritis (HP:0100653)1.19593832
90Abnormal urine output (HP:0012590)1.17635854
91Genital tract atresia (HP:0001827)1.16845999
92Poor coordination (HP:0002370)1.16638774
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.16341998
94Short thorax (HP:0010306)1.14747631
95Nephropathy (HP:0000112)1.14394373
96Retinal dysplasia (HP:0007973)1.12700878
97Hemiparesis (HP:0001269)1.12048733
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.11686247
99Abnormality of saccadic eye movements (HP:0000570)1.10388112
100Vascular calcification (HP:0004934)1.10284530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.56058274
2PDK38.56058274
3TESK15.93532271
4PDK25.54709490
5PRKD34.34045736
6ICK4.02965484
7PTK2B2.19407825
8WNK42.00046354
9PNCK1.96810223
10STK391.94471692
11NEK21.88147129
12STK381.63459063
13DYRK1B1.31294959
14PDK11.11229510
15DYRK30.98819245
16IRAK10.82694640
17MAP2K60.82353157
18TTK0.81756568
19TYRO30.78028502
20RIPK40.77677960
21WNK10.76827034
22CDK120.73959183
23MAPK150.70632987
24PASK0.70063634
25CHEK20.69631328
26STK30.65304693
27TESK20.63802529
28CCNB10.62544066
29PDPK10.58644670
30CAMK1G0.55882766
31SCYL20.53315062
32PLK40.51312691
33PINK10.50653847
34LMTK20.49005652
35WEE10.43110595
36EEF2K0.42451768
37CHEK10.41308286
38PRKCG0.39352055
39SRPK10.39344701
40CDC70.38520158
41ATR0.37602627
42IRAK20.37015357
43ATM0.33969126
44NTRK20.32597684
45MUSK0.32311025
46PAK10.31835895
47STK38L0.31317264
48PLK10.29620956
49MTOR0.26634178
50BRSK20.22935824
51MAP4K10.20803391
52PAK20.19181587
53CAMKK10.18084901
54MAP3K100.16725906
55CSF1R0.16139997
56MARK20.15478669
57PRKAA10.15327285
58CDK150.15189025
59MAPKAPK50.14684531
60RPS6KB10.12006092
61CDK180.12005437
62NEK60.11929327
63CDK11A0.11564872
64PRKCZ0.10685112
65MARK30.10566768
66PAK40.10320064
67CSNK2A10.09604016
68PRKCQ0.09550435
69CSNK1D0.08364842
70YES10.08360317
71PRKCD0.08331959
72PKN10.07478528
73CDK140.07108989
74CDK20.06442741
75GSK3B0.05563524
76EGFR0.05163581
77RPS6KA10.05009861
78PRKG20.04936393
79CDK10.04517460
80PRKACG0.04482480
81STK100.04355953
82CSNK2A20.03936373
83BRSK10.03435468
84PRKG10.03336782
85PRKCA0.01617822
86CDK40.01191490
87PRKCB0.00929422
88CAMK2A0.00901861
89MAPK80.00607190
90PRKDC0.00471366
91AURKA0.00065659
92CSK-0.0432195
93PRKACA-0.0319738
94PIM1-0.0276396
95TXK-0.0271708
96STK11-0.0199919
97MAP3K5-0.0165592
98ZAP70-0.0162237
99CDK6-0.0149640
100PRKACB-0.0121234

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.57725300
2Fatty acid biosynthesis_Homo sapiens_hsa000614.32219418
3Vitamin B6 metabolism_Homo sapiens_hsa007504.19039209
4Pyruvate metabolism_Homo sapiens_hsa006203.75592500
5Propanoate metabolism_Homo sapiens_hsa006403.04608885
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.01217183
7Linoleic acid metabolism_Homo sapiens_hsa005912.89467852
8Glucagon signaling pathway_Homo sapiens_hsa049222.55354448
9Selenocompound metabolism_Homo sapiens_hsa004502.30637549
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30319209
11Basal transcription factors_Homo sapiens_hsa030222.27003740
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.17089237
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13882249
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.02093194
15Glycerolipid metabolism_Homo sapiens_hsa005611.87841718
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.79317941
17PPAR signaling pathway_Homo sapiens_hsa033201.78068159
18Pentose phosphate pathway_Homo sapiens_hsa000301.76222601
19Fanconi anemia pathway_Homo sapiens_hsa034601.74791462
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73800897
21Fructose and mannose metabolism_Homo sapiens_hsa000511.68020678
22Oocyte meiosis_Homo sapiens_hsa041141.67966699
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.53240574
24Ether lipid metabolism_Homo sapiens_hsa005651.47023882
25Amphetamine addiction_Homo sapiens_hsa050311.45880128
26Carbon metabolism_Homo sapiens_hsa012001.41183101
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.39768646
28Mineral absorption_Homo sapiens_hsa049781.38585697
29Dorso-ventral axis formation_Homo sapiens_hsa043201.31360748
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23446573
31Fat digestion and absorption_Homo sapiens_hsa049751.22125315
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21555099
33Antigen processing and presentation_Homo sapiens_hsa046121.20951407
34Fatty acid degradation_Homo sapiens_hsa000711.20537791
35Glutathione metabolism_Homo sapiens_hsa004801.19830314
36Cardiac muscle contraction_Homo sapiens_hsa042601.19566973
37Purine metabolism_Homo sapiens_hsa002301.19434524
38Collecting duct acid secretion_Homo sapiens_hsa049661.16812122
39Fatty acid metabolism_Homo sapiens_hsa012121.15817585
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14632025
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13782659
42Huntingtons disease_Homo sapiens_hsa050161.12651843
43Renin secretion_Homo sapiens_hsa049241.09658283
44RNA transport_Homo sapiens_hsa030131.06388147
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04114652
46Biosynthesis of amino acids_Homo sapiens_hsa012300.96311377
47Chemical carcinogenesis_Homo sapiens_hsa052040.93988762
48mRNA surveillance pathway_Homo sapiens_hsa030150.90861088
49Arachidonic acid metabolism_Homo sapiens_hsa005900.84906268
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83311958
51Legionellosis_Homo sapiens_hsa051340.83011553
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68575844
53Systemic lupus erythematosus_Homo sapiens_hsa053220.67345288
54Hedgehog signaling pathway_Homo sapiens_hsa043400.66543509
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63014633
56Insulin secretion_Homo sapiens_hsa049110.59883686
57Long-term potentiation_Homo sapiens_hsa047200.58128918
58ABC transporters_Homo sapiens_hsa020100.57982345
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.57215393
60Pyrimidine metabolism_Homo sapiens_hsa002400.56379961
61Renin-angiotensin system_Homo sapiens_hsa046140.55588971
62Bile secretion_Homo sapiens_hsa049760.54888221
63Synaptic vesicle cycle_Homo sapiens_hsa047210.51868149
64Estrogen signaling pathway_Homo sapiens_hsa049150.49215360
65Thyroid hormone synthesis_Homo sapiens_hsa049180.48894193
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46919229
67Calcium signaling pathway_Homo sapiens_hsa040200.45354495
68Metabolic pathways_Homo sapiens_hsa011000.44552383
69Homologous recombination_Homo sapiens_hsa034400.42614235
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42103500
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.41325928
72Pancreatic secretion_Homo sapiens_hsa049720.35366975
73Protein digestion and absorption_Homo sapiens_hsa049740.34643237
74Inositol phosphate metabolism_Homo sapiens_hsa005620.34008657
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32149392
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31172475
77Salivary secretion_Homo sapiens_hsa049700.29940996
78VEGF signaling pathway_Homo sapiens_hsa043700.29152120
79Retinol metabolism_Homo sapiens_hsa008300.27328983
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26142556
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.24904808
82Salmonella infection_Homo sapiens_hsa051320.24758759
83Endocytosis_Homo sapiens_hsa041440.23805727
84Taste transduction_Homo sapiens_hsa047420.23511265
85N-Glycan biosynthesis_Homo sapiens_hsa005100.21441286
86Alcoholism_Homo sapiens_hsa050340.21369729
87AMPK signaling pathway_Homo sapiens_hsa041520.20026534
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19228497
89cAMP signaling pathway_Homo sapiens_hsa040240.18030333
90Gastric acid secretion_Homo sapiens_hsa049710.17677986
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17366931
92Sulfur metabolism_Homo sapiens_hsa009200.17093217
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15804556
94DNA replication_Homo sapiens_hsa030300.15776250
95Staphylococcus aureus infection_Homo sapiens_hsa051500.15305091
96Non-homologous end-joining_Homo sapiens_hsa034500.15169563
97Rheumatoid arthritis_Homo sapiens_hsa053230.15141395
98Phagosome_Homo sapiens_hsa041450.14271205
99B cell receptor signaling pathway_Homo sapiens_hsa046620.11502252
100Complement and coagulation cascades_Homo sapiens_hsa046100.08872940

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »