TMEM229A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.16409051
2axon ensheathment in central nervous system (GO:0032291)9.16409051
3L-amino acid import (GO:0043092)5.38917811
4fatty acid elongation (GO:0030497)5.06968814
5myelination (GO:0042552)4.72863008
6ensheathment of neurons (GO:0007272)4.70421683
7axon ensheathment (GO:0008366)4.70421683
8myelin maintenance (GO:0043217)4.46332010
9cellular potassium ion homeostasis (GO:0030007)4.38789265
10neurofilament cytoskeleton organization (GO:0060052)4.33630852
11amino acid import (GO:0043090)4.29080337
12postsynaptic membrane organization (GO:0001941)4.10711122
13long-chain fatty acid biosynthetic process (GO:0042759)4.06876429
14neurotransmitter uptake (GO:0001504)3.92113213
15negative regulation of neurotransmitter transport (GO:0051589)3.82489120
16potassium ion import (GO:0010107)3.76332231
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72572479
18sodium ion export (GO:0071436)3.69077179
19establishment of mitochondrion localization (GO:0051654)3.68894830
20protein neddylation (GO:0045116)3.65414258
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60978984
22protein localization to synapse (GO:0035418)3.55097226
23neuronal action potential propagation (GO:0019227)3.53595485
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.53353998
25chaperone-mediated protein transport (GO:0072321)3.52655346
26presynaptic membrane organization (GO:0097090)3.47190065
27regulation of synapse structural plasticity (GO:0051823)3.46442647
28exploration behavior (GO:0035640)3.44330278
29neuron cell-cell adhesion (GO:0007158)3.42718686
30response to methylmercury (GO:0051597)3.42193663
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40507447
32C4-dicarboxylate transport (GO:0015740)3.39709665
33synaptic vesicle maturation (GO:0016188)3.39078201
34gamma-aminobutyric acid transport (GO:0015812)3.37902912
35potassium ion homeostasis (GO:0055075)3.34110856
36negative regulation of neurotransmitter secretion (GO:0046929)3.33826800
37negative regulation of protein localization to cell surface (GO:2000009)3.32222193
38oligodendrocyte differentiation (GO:0048709)3.26537275
39presynaptic membrane assembly (GO:0097105)3.24060685
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.23401031
41regulation of synaptic vesicle transport (GO:1902803)3.20955117
42regulation of Rac GTPase activity (GO:0032314)3.15748709
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15257253
44ATP synthesis coupled proton transport (GO:0015986)3.13022337
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13022337
46import into cell (GO:0098657)3.08200349
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07477911
48synaptic transmission, glutamatergic (GO:0035249)3.05213179
49cGMP-mediated signaling (GO:0019934)3.04466389
50photoreceptor cell differentiation (GO:0046530)3.04256299
51eye photoreceptor cell differentiation (GO:0001754)3.04256299
52cerebral cortex radially oriented cell migration (GO:0021799)3.03929634
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03226805
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.02591078
55apical protein localization (GO:0045176)2.98982385
56creatine metabolic process (GO:0006600)2.97944869
57asymmetric protein localization (GO:0008105)2.97242124
58positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.95731744
59adult walking behavior (GO:0007628)2.95708603
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94966350
61regulation of collateral sprouting (GO:0048670)2.93187320
62membrane repolarization (GO:0086009)2.92688629
63acidic amino acid transport (GO:0015800)2.91772805
64glycine transport (GO:0015816)2.89970401
65behavioral response to cocaine (GO:0048148)2.89345766
66neurotransmitter secretion (GO:0007269)2.89063460
67negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86186542
68synaptic vesicle exocytosis (GO:0016079)2.85693440
69neuron-neuron synaptic transmission (GO:0007270)2.84688886
70detection of temperature stimulus involved in sensory perception (GO:0050961)2.82564235
71detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.82564235
72glutamate secretion (GO:0014047)2.81905857
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.81341124
74L-glutamate transport (GO:0015813)2.81276620
75locomotory exploration behavior (GO:0035641)2.81036076
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80877973
77transmission of nerve impulse (GO:0019226)2.79108182
78cellular sodium ion homeostasis (GO:0006883)2.77664273
79respiratory electron transport chain (GO:0022904)2.77542003
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76148211
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.76092956
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75667064
83relaxation of smooth muscle (GO:0044557)2.74851521
84very long-chain fatty acid metabolic process (GO:0000038)2.74033612
85regulation of dendritic spine morphogenesis (GO:0061001)2.73264259
86regulation of voltage-gated calcium channel activity (GO:1901385)2.71523470
87neuron remodeling (GO:0016322)2.69829608
88electron transport chain (GO:0022900)2.69361390
89auditory behavior (GO:0031223)2.67741501
90astrocyte development (GO:0014002)2.67459285
91mechanosensory behavior (GO:0007638)2.66957131
92response to histamine (GO:0034776)2.66722494
93glutathione biosynthetic process (GO:0006750)2.64876305
94proline transport (GO:0015824)2.64451005
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63988169
96neuron recognition (GO:0008038)2.62852752
97long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.62152234
98myelination in peripheral nervous system (GO:0022011)2.62093692
99peripheral nervous system axon ensheathment (GO:0032292)2.62093692
100cerebellar Purkinje cell differentiation (GO:0021702)2.61756996
101nonribosomal peptide biosynthetic process (GO:0019184)2.61726702
102dendrite morphogenesis (GO:0048813)2.60847143
103regulation of synaptic vesicle exocytosis (GO:2000300)2.59283308
104vocalization behavior (GO:0071625)2.59273577
105positive regulation of potassium ion transport (GO:0043268)2.59082182
106glycerophospholipid catabolic process (GO:0046475)2.58265168
107regulation of guanylate cyclase activity (GO:0031282)2.55958175
108nerve growth factor signaling pathway (GO:0038180)2.55496822
109positive regulation of potassium ion transmembrane transport (GO:1901381)2.55008448
110dendritic spine morphogenesis (GO:0060997)2.54648320
111response to lead ion (GO:0010288)2.54548169
112negative regulation of response to food (GO:0032096)2.54402719
113negative regulation of appetite (GO:0032099)2.54402719
114regulation of neuronal synaptic plasticity (GO:0048168)2.53798309
115neurotransmitter transport (GO:0006836)2.52478021
116glutamate receptor signaling pathway (GO:0007215)2.52120779
117substantia nigra development (GO:0021762)2.52046757
118detection of temperature stimulus (GO:0016048)2.51684073
119cerebellar granule cell differentiation (GO:0021707)2.50560836
120otic vesicle formation (GO:0030916)2.50470441
121dicarboxylic acid catabolic process (GO:0043649)2.50398379
122cholesterol biosynthetic process (GO:0006695)2.50203423
123regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49123457
124cell communication by electrical coupling (GO:0010644)2.48414071
125positive regulation of oligodendrocyte differentiation (GO:0048714)2.47781821
126substrate-independent telencephalic tangential migration (GO:0021826)2.46926701
127substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46926701
128regulation of neurotransmitter uptake (GO:0051580)2.46167550
129fatty-acyl-CoA biosynthetic process (GO:0046949)2.46044295
130response to auditory stimulus (GO:0010996)2.45116185
131magnesium ion transport (GO:0015693)2.44730979
132regulation of glutamate receptor signaling pathway (GO:1900449)2.44664703
133regulation of neurotransmitter transport (GO:0051588)2.41391752
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.41083360
135membrane repolarization during action potential (GO:0086011)2.40714771
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40690948
137positive regulation of synapse assembly (GO:0051965)2.40514317
138regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39681943
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.37777267
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37661046
141regulation of neurotransmitter secretion (GO:0046928)2.37207829
142neuromuscular synaptic transmission (GO:0007274)2.36958624
143regulation of long-term neuronal synaptic plasticity (GO:0048169)2.36722707
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.36688977
145retinal rod cell development (GO:0046548)2.36497972
146synaptic vesicle endocytosis (GO:0048488)2.35792675
147axonal fasciculation (GO:0007413)2.35772345
148regulation of response to food (GO:0032095)2.34471842
149regulation of neurotransmitter levels (GO:0001505)2.34443734
150neuromuscular process controlling balance (GO:0050885)2.33960372
151regulation of synaptic transmission, GABAergic (GO:0032228)2.33709963
152positive regulation of dendritic spine development (GO:0060999)2.33401157
153membrane tubulation (GO:0097320)2.33085023
154neuronal ion channel clustering (GO:0045161)2.32694069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.70875382
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.38565604
3GBX2_23144817_ChIP-Seq_PC3_Human3.19204920
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78768263
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76063653
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58918706
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42964148
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35610482
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35610482
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35463457
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32609416
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27553869
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25563443
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20412108
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.19613861
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15150592
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.14063736
18* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07946576
19AR_21572438_ChIP-Seq_LNCaP_Human2.03016563
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00626232
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00195044
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.95845139
23DROSHA_22980978_ChIP-Seq_HELA_Human1.85792287
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.84755984
25TAF15_26573619_Chip-Seq_HEK293_Human1.76910108
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71245989
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70852284
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67965191
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64306636
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.62728024
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.59715341
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.55620356
33VDR_22108803_ChIP-Seq_LS180_Human1.53564290
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.52741100
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52517307
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51589971
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50064390
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49951635
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48283585
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47547262
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42853071
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41589958
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41550243
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40282966
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40053979
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39096699
47* P300_19829295_ChIP-Seq_ESCs_Human1.38729809
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.35639150
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35102057
50SMAD4_21799915_ChIP-Seq_A2780_Human1.32360386
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.30757995
52EWS_26573619_Chip-Seq_HEK293_Human1.26921269
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26168109
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.25421426
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24384299
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23830136
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23308423
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22409032
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22278831
60ER_23166858_ChIP-Seq_MCF-7_Human1.22196563
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20162421
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17659225
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16186193
64STAT3_23295773_ChIP-Seq_U87_Human1.15860967
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.15550540
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14754748
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14751505
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.14387983
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14262655
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13869508
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13469746
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12562265
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.11970538
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10995530
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10374621
76AHR_22903824_ChIP-Seq_MCF-7_Human1.09660231
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07991433
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07884892
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07852661
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06665729
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06239095
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06207194
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06207194
84AR_25329375_ChIP-Seq_VCAP_Human1.05893741
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04764142
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04197761
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.03339697
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.02761401
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02159434
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.02021047
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01624193
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01624193
93ZNF274_21170338_ChIP-Seq_K562_Hela1.00527207
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.00071826
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99432167
96IGF1R_20145208_ChIP-Seq_DFB_Human0.99009221
97RXR_22108803_ChIP-Seq_LS180_Human0.97974359
98TP53_16413492_ChIP-PET_HCT116_Human0.97698510
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97513741
100TCF4_23295773_ChIP-Seq_U87_Human0.97298830
101TP53_18474530_ChIP-ChIP_U2OS_Human0.96397866
102TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95114263
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94973588
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94847963
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.94733201
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.94207944
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94150761
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93830814
109* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93779141
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93653531
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.93563828
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93404053
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93323439
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93274500
115BCAT_22108803_ChIP-Seq_LS180_Human0.91762212
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91314274
117TRIM28_21343339_ChIP-Seq_HEK293_Human0.91209525
118SOX9_26525672_Chip-Seq_HEART_Mouse0.90493401
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.90016758
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88612373
121RUNX2_22187159_ChIP-Seq_PCA_Human0.88515577
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88477010
123FUS_26573619_Chip-Seq_HEK293_Human0.88028778
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87881945
125RNF2_27304074_Chip-Seq_NSC_Mouse0.87468836
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86329592
127NANOG_19829295_ChIP-Seq_ESCs_Human0.85960474
128* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85608337
129AR_19668381_ChIP-Seq_PC3_Human0.85404227
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.85256084
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.84977657
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.84934870
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84510591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.73949853
2MP0000920_abnormal_myelination3.71269687
3MP0003880_abnormal_central_pattern3.59716082
4MP0004885_abnormal_endolymph3.50693041
5MP0004859_abnormal_synaptic_plasticity3.48343785
6MP0009379_abnormal_foot_pigmentation3.39551114
7MP0004043_abnormal_pH_regulation3.13852395
8MP0005423_abnormal_somatic_nervous2.85578617
9MP0001486_abnormal_startle_reflex2.77260100
10MP0003329_amyloid_beta_deposits2.76790461
11MP0003690_abnormal_glial_cell2.74094112
12MP0002638_abnormal_pupillary_reflex2.72157615
13MP0002064_seizures2.68668092
14MP0003635_abnormal_synaptic_transmissio2.65255780
15MP0003787_abnormal_imprinting2.56741548
16MP0002272_abnormal_nervous_system2.51201878
17MP0009046_muscle_twitch2.46365310
18MP0009745_abnormal_behavioral_response2.35775422
19MP0001485_abnormal_pinna_reflex2.25589894
20MP0006292_abnormal_olfactory_placode2.16587461
21MP0002734_abnormal_mechanical_nocicepti2.15282495
22MP0001188_hyperpigmentation2.07006386
23MP0003634_abnormal_glial_cell2.05745115
24MP0002063_abnormal_learning/memory/cond2.05619970
25MP0003950_abnormal_plasma_membrane2.00702273
26MP0002572_abnormal_emotion/affect_behav1.95407631
27MP0004142_abnormal_muscle_tone1.95364235
28MP0000778_abnormal_nervous_system1.92495877
29MP0001968_abnormal_touch/_nociception1.92493864
30MP0004742_abnormal_vestibular_system1.88968550
31MP0003136_yellow_coat_color1.88386621
32MP0003633_abnormal_nervous_system1.75550017
33MP0001905_abnormal_dopamine_level1.75029041
34MP0001529_abnormal_vocalization1.73827666
35MP0002067_abnormal_sensory_capabilities1.68497044
36MP0004858_abnormal_nervous_system1.68009761
37MP0008569_lethality_at_weaning1.63295450
38MP0002735_abnormal_chemical_nociception1.63188693
39MP0001970_abnormal_pain_threshold1.59018348
40MP0003631_nervous_system_phenotype1.58228029
41MP0001440_abnormal_grooming_behavior1.57421110
42MP0008877_abnormal_DNA_methylation1.55527468
43MP0002229_neurodegeneration1.54030827
44MP0002733_abnormal_thermal_nociception1.51810306
45MP0002736_abnormal_nociception_after1.47609291
46MP0004133_heterotaxia1.47246652
47MP0005171_absent_coat_pigmentation1.46316118
48MP0003890_abnormal_embryonic-extraembry1.43340479
49MP0003195_calcinosis1.43035192
50MP0003011_delayed_dark_adaptation1.42056591
51MP0003632_abnormal_nervous_system1.41788098
52MP0005394_taste/olfaction_phenotype1.39973266
53MP0005499_abnormal_olfactory_system1.39973266
54MP0005377_hearing/vestibular/ear_phenot1.39910447
55MP0003878_abnormal_ear_physiology1.39910447
56MP0005332_abnormal_amino_acid1.39808055
57MP0000955_abnormal_spinal_cord1.37365812
58MP0001293_anophthalmia1.36501562
59MP0000604_amyloidosis1.34469723
60MP0002066_abnormal_motor_capabilities/c1.34297805
61MP0002882_abnormal_neuron_morphology1.33917972
62MP0001963_abnormal_hearing_physiology1.33880855
63MP0003315_abnormal_perineum_morphology1.28335481
64MP0003121_genomic_imprinting1.25507786
65MP0005386_behavior/neurological_phenoty1.24908499
66MP0004924_abnormal_behavior1.24908499
67MP0005409_darkened_coat_color1.24498477
68MP0003119_abnormal_digestive_system1.22765913
69MP0006072_abnormal_retinal_apoptosis1.20662299
70MP0001501_abnormal_sleep_pattern1.20140110
71MP0009780_abnormal_chondrocyte_physiolo1.19485717
72MP0003123_paternal_imprinting1.18169922
73MP0005646_abnormal_pituitary_gland1.15724254
74MP0002557_abnormal_social/conspecific_i1.15605599
75MP0005187_abnormal_penis_morphology1.14168242
76MP0005551_abnormal_eye_electrophysiolog1.13925932
77MP0002822_catalepsy1.12083768
78MP0001299_abnormal_eye_distance/1.11721341
79MP0001502_abnormal_circadian_rhythm1.10591079
80MP0001177_atelectasis1.09160334
81MP0003879_abnormal_hair_cell1.09015946
82MP0005410_abnormal_fertilization1.08815577
83MP0001765_abnormal_ion_homeostasis1.07789387
84MP0004147_increased_porphyrin_level1.06809029
85MP0005248_abnormal_Harderian_gland1.06793386
86MP0003122_maternal_imprinting1.05255595
87MP0002938_white_spotting1.04384379
88MP0010678_abnormal_skin_adnexa1.04001157
89MP0000566_synostosis0.99381786
90MP0005058_abnormal_lysosome_morphology0.99133994
91MP0004215_abnormal_myocardial_fiber0.98879456
92MP0002752_abnormal_somatic_nervous0.97726086
93MP0002102_abnormal_ear_morphology0.97186187
94MP0010030_abnormal_orbit_morphology0.96658254
95MP0002160_abnormal_reproductive_system0.95831713
96MP0008260_abnormal_autophagy0.95337868
97MP0002184_abnormal_innervation0.95163963
98MP0003861_abnormal_nervous_system0.94561589
99MP0002152_abnormal_brain_morphology0.93231974
100MP0000747_muscle_weakness0.93046440
101MP0008789_abnormal_olfactory_epithelium0.92597343
102MP0002751_abnormal_autonomic_nervous0.91550109
103MP0000026_abnormal_inner_ear0.88713207
104MP0005174_abnormal_tail_pigmentation0.88045157
105MP0004134_abnormal_chest_morphology0.87411397
106MP0005645_abnormal_hypothalamus_physiol0.85577586
107MP0000462_abnormal_digestive_system0.82347057
108MP0004811_abnormal_neuron_physiology0.82199404
109MP0003075_altered_response_to0.82094491
110MP0005360_urolithiasis0.80088207
111MP0003937_abnormal_limbs/digits/tail_de0.80057112
112MP0006276_abnormal_autonomic_nervous0.79625773
113MP0001958_emphysema0.79353033
114MP0003938_abnormal_ear_development0.77043757
115MP0003137_abnormal_impulse_conducting0.76040767
116MP0001666_abnormal_nutrient_absorption0.74950094
117MP0001986_abnormal_taste_sensitivity0.73600346
118MP0001984_abnormal_olfaction0.70846508
119MP0005253_abnormal_eye_physiology0.70563382
120MP0005623_abnormal_meninges_morphology0.68755998
121MP0002069_abnormal_eating/drinking_beha0.66831489
122MP0005195_abnormal_posterior_eye0.65437276
123MP0005451_abnormal_body_composition0.65385914
124MP0002090_abnormal_vision0.64256366
125MP0004145_abnormal_muscle_electrophysio0.63009815
126MP0000631_abnormal_neuroendocrine_gland0.63007090
127MP0001664_abnormal_digestion0.61713246
128MP0005584_abnormal_enzyme/coenzyme_acti0.60817291
129MP0000383_abnormal_hair_follicle0.59487331
130MP0000647_abnormal_sebaceous_gland0.59379182
131MP0001346_abnormal_lacrimal_gland0.58517686
132MP0008874_decreased_physiological_sensi0.58345580
133MP0004019_abnormal_vitamin_homeostasis0.58082081
134MP0000579_abnormal_nail_morphology0.57375591

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.40466208
2Increased circulating renin level (HP:0000848)5.02672781
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.82345207
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.82345207
5Metabolic alkalosis (HP:0200114)4.68751584
6Hypokalemic alkalosis (HP:0001949)4.31007367
7Myokymia (HP:0002411)4.26994993
8Hypomagnesemia (HP:0002917)4.20118544
9Cerebral inclusion bodies (HP:0100314)4.00335258
10Abnormality of the corticospinal tract (HP:0002492)3.83170153
11Septo-optic dysplasia (HP:0100842)3.75633539
12Atonic seizures (HP:0010819)3.69265761
13Peripheral hypomyelination (HP:0007182)3.68730711
14Supranuclear gaze palsy (HP:0000605)3.62949930
15Focal motor seizures (HP:0011153)3.53828345
16Termporal pattern (HP:0011008)3.44663398
17Insidious onset (HP:0003587)3.44663398
18Abnormality of magnesium homeostasis (HP:0004921)3.36628226
19Onion bulb formation (HP:0003383)3.28934268
20Aplasia involving bones of the upper limbs (HP:0009823)3.20118819
21Aplasia of the phalanges of the hand (HP:0009802)3.20118819
22Aplasia involving bones of the extremities (HP:0009825)3.20118819
23Megalencephaly (HP:0001355)3.19661402
24Polyphagia (HP:0002591)3.15389554
25Ankle clonus (HP:0011448)3.10874469
26Intention tremor (HP:0002080)3.09826687
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07624807
28Abnormal auditory evoked potentials (HP:0006958)3.04007120
29Spastic gait (HP:0002064)3.02832034
30Polyuria (HP:0000103)3.00885592
31Partial duplication of thumb phalanx (HP:0009944)2.97188679
32Abnormal urine output (HP:0012590)2.95786263
33Dysmetria (HP:0001310)2.92354134
34Clumsiness (HP:0002312)2.91402280
35Abnormal drinking behavior (HP:0030082)2.87704104
36Polydipsia (HP:0001959)2.87704104
37Action tremor (HP:0002345)2.83028528
38Segmental peripheral demyelination/remyelination (HP:0003481)2.80179144
39Hepatoblastoma (HP:0002884)2.76153807
40Pheochromocytoma (HP:0002666)2.74409427
41Retinal dysplasia (HP:0007973)2.73210855
42Febrile seizures (HP:0002373)2.69319042
43Abnormality of renal excretion (HP:0011036)2.68790729
44Confusion (HP:0001289)2.67079607
45Abnormality of the labia minora (HP:0012880)2.62664726
46Diplopia (HP:0000651)2.58536356
47Abnormality of binocular vision (HP:0011514)2.58536356
48Hyperaldosteronism (HP:0000859)2.57595701
49Absence seizures (HP:0002121)2.56667219
50Scanning speech (HP:0002168)2.55487978
51Hemiparesis (HP:0001269)2.55080955
52Focal seizures (HP:0007359)2.51047892
53Optic nerve hypoplasia (HP:0000609)2.48495738
54Abnormality of renin-angiotensin system (HP:0000847)2.47380473
55Partial duplication of the phalanx of hand (HP:0009999)2.47084684
56Limb dystonia (HP:0002451)2.46621904
57Renal salt wasting (HP:0000127)2.41221302
58Urinary urgency (HP:0000012)2.40740109
59Epileptic encephalopathy (HP:0200134)2.40119893
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.38679339
61Parakeratosis (HP:0001036)2.35188616
62Abnormal eating behavior (HP:0100738)2.34440705
63Lower limb muscle weakness (HP:0007340)2.32130144
64Split foot (HP:0001839)2.30902511
65Sensory axonal neuropathy (HP:0003390)2.30263076
66Neuroendocrine neoplasm (HP:0100634)2.29527083
67Thickened helices (HP:0000391)2.27772814
68Alacrima (HP:0000522)2.26835339
69Hyperventilation (HP:0002883)2.25682069
70Increased hepatocellular lipid droplets (HP:0006565)2.24057594
71Hyperglycinuria (HP:0003108)2.23800992
72Colon cancer (HP:0003003)2.23380222
73Dysdiadochokinesis (HP:0002075)2.23218020
74Macrocytic anemia (HP:0001972)2.20928431
75Abnormality of the middle phalanges of the toes (HP:0010183)2.18364623
76Morphological abnormality of the inner ear (HP:0011390)2.16484043
77Reticulocytopenia (HP:0001896)2.16329611
78Alkalosis (HP:0001948)2.15307686
79Hyperactive renin-angiotensin system (HP:0000841)2.14084814
80Abnormality of chloride homeostasis (HP:0011422)2.12664935
81Spastic tetraparesis (HP:0001285)2.12250840
82Slow saccadic eye movements (HP:0000514)2.11104945
83Axonal loss (HP:0003447)2.09926679
84Acute necrotizing encephalopathy (HP:0006965)2.09497970
85Abnormality of glycine metabolism (HP:0010895)2.09356481
86Abnormality of serine family amino acid metabolism (HP:0010894)2.09356481
87Abnormality of the vitamin B12 metabolism (HP:0004341)2.08887600
88Anosmia (HP:0000458)2.06296862
89Lipid accumulation in hepatocytes (HP:0006561)2.04952465
90Broad-based gait (HP:0002136)1.99331233
91Maternal diabetes (HP:0009800)1.98651194
92Generalized tonic-clonic seizures (HP:0002069)1.95717246
93Gait imbalance (HP:0002141)1.94703188
94Anophthalmia (HP:0000528)1.93858987
95Synostosis involving the elbow (HP:0003938)1.92665316
96Humeroradial synostosis (HP:0003041)1.92665316
97Mutism (HP:0002300)1.92613368
98Acanthocytosis (HP:0001927)1.91163031
99Hemiplegia (HP:0002301)1.89812404
100Truncal ataxia (HP:0002078)1.89314598
101Clonus (HP:0002169)1.88673304
102Leukodystrophy (HP:0002415)1.88553586
103Sleep apnea (HP:0010535)1.86374511
104Gout (HP:0001997)1.86325830
105Mitochondrial inheritance (HP:0001427)1.86147637
106Abnormal mitochondria in muscle tissue (HP:0008316)1.85899778
107Ulnar claw (HP:0001178)1.85687905
108Progressive cerebellar ataxia (HP:0002073)1.85349202
109Coronal craniosynostosis (HP:0004440)1.85004642
110Postural instability (HP:0002172)1.84844128
111Anxiety (HP:0000739)1.84809128
112Abnormality of vitamin B metabolism (HP:0004340)1.84157149
113Rib fusion (HP:0000902)1.84122161
114Cerebral hemorrhage (HP:0001342)1.81791298
115Diaphragmatic weakness (HP:0009113)1.81674868
116Renal Fanconi syndrome (HP:0001994)1.81493383
117Urinary bladder sphincter dysfunction (HP:0002839)1.80765048
118Hypoplasia of the iris (HP:0007676)1.80546228
119Progressive macrocephaly (HP:0004481)1.80190628
120Status epilepticus (HP:0002133)1.79597688
121Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79260388
122Myelomeningocele (HP:0002475)1.79181855
123Choreoathetosis (HP:0001266)1.78453546
124Dialeptic seizures (HP:0011146)1.76974955
125Neuronal loss in central nervous system (HP:0002529)1.76168302
126Absent septum pellucidum (HP:0001331)1.74242525
127Growth hormone deficiency (HP:0000824)1.73433448
128Hyperglycinemia (HP:0002154)1.72975256
129Vaginal atresia (HP:0000148)1.71476917
130Adrenal hypoplasia (HP:0000835)1.71258384
131Methylmalonic acidemia (HP:0002912)1.70752676
132Urinary incontinence (HP:0000020)1.70588238
133Impaired vibration sensation in the lower limbs (HP:0002166)1.70356165
134Anteriorly placed anus (HP:0001545)1.69815938
135Morphological abnormality of the pyramidal tract (HP:0002062)1.69353316
136Abnormal number of incisors (HP:0011064)1.69339217
137Hyperphosphaturia (HP:0003109)1.69226801
138Acute encephalopathy (HP:0006846)1.69211105
139Hypophosphatemic rickets (HP:0004912)1.68706565
140Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68521179
141Genital tract atresia (HP:0001827)1.68274899
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68024906
143Hypokalemia (HP:0002900)1.67267697
144Autoamputation (HP:0001218)1.65909407
145Abnormality of the septum pellucidum (HP:0007375)1.65449364
146CNS hypomyelination (HP:0003429)1.65132856
147Cerebral hypomyelination (HP:0006808)1.65009935
148Congenital primary aphakia (HP:0007707)1.64429291
149Abnormality of cochlea (HP:0000375)1.63959359
150Generalized myoclonic seizures (HP:0002123)1.63808882
151Hammertoe (HP:0001765)1.63301387
152Impulsivity (HP:0100710)1.61765990
153Primary amenorrhea (HP:0000786)1.61313866
154Cutaneous finger syndactyly (HP:0010554)1.61272234
155Megaloblastic anemia (HP:0001889)1.60904666
156Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.60687289
157Decreased activity of mitochondrial respiratory chain (HP:0008972)1.60687289
158Patchy hypopigmentation of hair (HP:0011365)1.59457684
159Duplication of thumb phalanx (HP:0009942)1.59439834
160Medial flaring of the eyebrow (HP:0010747)1.58596516
161Breast aplasia (HP:0100783)1.57853353
162Male pseudohermaphroditism (HP:0000037)1.57471294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.07856431
2OXSR14.79785101
3WNK43.38628214
4EPHB12.49509362
5EPHA42.42801610
6NTRK12.37227160
7SGK4942.13138759
8SGK2232.13138759
9MUSK2.00128892
10WNK31.98907965
11WNK11.98000896
12FGFR21.97704734
13PKN11.95247512
14MAPKAPK51.88897999
15CASK1.85142315
16MARK11.75443270
17NTRK21.70731614
18BCR1.65506532
19CDK191.61501660
20NTRK31.58403871
21PAK61.54819164
22MAP3K91.54321308
23UHMK11.46460785
24CDC71.46168094
25PRKD31.45105606
26PNCK1.43481944
27CAMK2B1.40531063
28MET1.40493653
29LATS21.34771127
30ADRBK21.34676513
31PHKG11.27407850
32PHKG21.27407850
33LIMK11.25040986
34STK161.22955101
35TNIK1.19041007
36CDK51.18717088
37MINK11.17807486
38ROCK21.15330970
39MAP3K101.13498261
40KSR21.10284000
41NEK61.09177731
42WEE11.08300601
43PBK1.07318887
44CSNK1A1L1.06685171
45CSNK1G21.06559612
46ZAK1.05081828
47CAMK2D1.04661640
48MAP3K41.04093017
49ARAF1.01811109
50TESK21.01503716
51CSNK1G31.01089812
52CAMK2G0.98114034
53PAK30.97877195
54FGR0.97778150
55CAMK2A0.97444858
56PINK10.92182603
57SRPK10.91770665
58MAP3K130.91454261
59PRPF4B0.90769164
60BRSK10.90263820
61CAMKK10.89554940
62DYRK30.88159015
63TYRO30.88144071
64CDK140.86826425
65ERBB40.86702506
66MARK20.84719800
67CSNK1G10.80214812
68DAPK20.79346498
69PRKCE0.79177234
70CDK150.77742466
71MAPK130.77395306
72PLK30.75816962
73PRKCH0.75311741
74CDK180.74956720
75ACVR1B0.74812991
76MST40.74750263
77PRKG20.73851938
78PDPK10.72203338
79MAP2K70.71830239
80CAMK1G0.71537696
81GRK50.71241590
82BRAF0.70345505
83SGK20.69239141
84MARK30.68838231
85INSRR0.67819141
86PRKD10.67766871
87LMTK20.67243261
88CDK11A0.66733226
89CSNK1E0.65077434
90PLK40.64370704
91PRKCQ0.64163806
92VRK10.63105816
93STK110.63082632
94DMPK0.63059139
95CDK30.62895908
96SGK10.62128643
97RPS6KA50.60637563
98MAP3K20.58775877
99SGK30.58572122
100NME10.57389058
101CLK10.57002057
102PRKCG0.55933353
103DYRK1B0.54032326
104PLK20.53446460
105PLK10.53384836
106BMX0.52626376
107IRAK20.52482485
108DYRK1A0.50357074
109DAPK30.48915226
110FYN0.48765629
111MAPK120.48656513
112PDK10.46679574
113DYRK20.46292582
114MAP4K20.44448071
115FES0.44279203
116CSNK1A10.42237670
117MAP2K40.41837435
118NEK10.40479456
119TLK10.40470985
120PRKG10.40387689
121PRKCZ0.39920497
122GSK3A0.39701496
123RIPK40.38785385
124MAPK100.38546072
125PRKACB0.38527917
126FGFR10.37646766
127PRKACA0.37579916
128TTK0.37363511
129PRKCA0.37313907
130DAPK10.36832674
131MAP3K70.36476279
132PTK2B0.36289154
133RPS6KA30.35820027
134DDR20.35684215
135BMPR20.35371470
136CAMK10.34693941
137MKNK20.33399681
138CSNK1D0.33197925
139BMPR1B0.32413576

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.01521637
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78945586
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.72684661
4Fatty acid elongation_Homo sapiens_hsa000622.70367109
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.53889773
6Steroid biosynthesis_Homo sapiens_hsa001002.46560685
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25530931
8Ribosome_Homo sapiens_hsa030102.19875211
9Butanoate metabolism_Homo sapiens_hsa006502.07081823
10GABAergic synapse_Homo sapiens_hsa047271.97573103
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96326552
12Huntingtons disease_Homo sapiens_hsa050161.90042135
13Nicotine addiction_Homo sapiens_hsa050331.74855027
14Glutamatergic synapse_Homo sapiens_hsa047241.74654440
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73859823
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67402977
17Sulfur metabolism_Homo sapiens_hsa009201.60873926
18Gastric acid secretion_Homo sapiens_hsa049711.59614123
19Ether lipid metabolism_Homo sapiens_hsa005651.58046850
20Synaptic vesicle cycle_Homo sapiens_hsa047211.49785159
21Morphine addiction_Homo sapiens_hsa050321.48790133
22Salivary secretion_Homo sapiens_hsa049701.43474841
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39864375
24Collecting duct acid secretion_Homo sapiens_hsa049661.37833160
25Fat digestion and absorption_Homo sapiens_hsa049751.32921394
26Circadian entrainment_Homo sapiens_hsa047131.32157280
27Fatty acid biosynthesis_Homo sapiens_hsa000611.25819519
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25757669
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24599522
30Folate biosynthesis_Homo sapiens_hsa007901.23835629
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23522449
32Fatty acid metabolism_Homo sapiens_hsa012121.19752129
33Serotonergic synapse_Homo sapiens_hsa047261.13535583
34Mineral absorption_Homo sapiens_hsa049781.12561645
35Cocaine addiction_Homo sapiens_hsa050301.11893690
36Propanoate metabolism_Homo sapiens_hsa006401.11119768
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09374003
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06941534
39Histidine metabolism_Homo sapiens_hsa003401.06794510
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06697699
41Long-term depression_Homo sapiens_hsa047301.05131613
42Insulin secretion_Homo sapiens_hsa049111.05104403
43Bile secretion_Homo sapiens_hsa049761.05034977
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04790779
45Sphingolipid metabolism_Homo sapiens_hsa006001.04378706
46Axon guidance_Homo sapiens_hsa043601.03313664
47Olfactory transduction_Homo sapiens_hsa047401.00684278
48Vitamin B6 metabolism_Homo sapiens_hsa007500.98658653
49Dorso-ventral axis formation_Homo sapiens_hsa043200.96756875
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96311416
51Long-term potentiation_Homo sapiens_hsa047200.95607982
52Amphetamine addiction_Homo sapiens_hsa050310.95318281
53Dopaminergic synapse_Homo sapiens_hsa047280.95057399
54Renin secretion_Homo sapiens_hsa049240.93025355
55Taste transduction_Homo sapiens_hsa047420.92675506
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91085470
57Proteasome_Homo sapiens_hsa030500.90863219
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89259893
59Cholinergic synapse_Homo sapiens_hsa047250.86778782
60Oxidative phosphorylation_Homo sapiens_hsa001900.85169409
61Pancreatic secretion_Homo sapiens_hsa049720.84897339
62Cardiac muscle contraction_Homo sapiens_hsa042600.84722855
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84398903
64Phototransduction_Homo sapiens_hsa047440.83991681
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.83658502
66Arginine and proline metabolism_Homo sapiens_hsa003300.83377101
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81272861
68Oocyte meiosis_Homo sapiens_hsa041140.80013329
69Vitamin digestion and absorption_Homo sapiens_hsa049770.77329875
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77285775
71Protein digestion and absorption_Homo sapiens_hsa049740.75911849
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74410656
73Biosynthesis of amino acids_Homo sapiens_hsa012300.73572955
74Basal cell carcinoma_Homo sapiens_hsa052170.72076697
75Peroxisome_Homo sapiens_hsa041460.71433521
76RNA polymerase_Homo sapiens_hsa030200.70461117
77Gap junction_Homo sapiens_hsa045400.70411271
78Renin-angiotensin system_Homo sapiens_hsa046140.69961003
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69740242
80cAMP signaling pathway_Homo sapiens_hsa040240.69111259
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.69015838
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66617371
83Thyroid hormone synthesis_Homo sapiens_hsa049180.66111093
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64974333
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.64918283
86Alcoholism_Homo sapiens_hsa050340.64346014
87Alzheimers disease_Homo sapiens_hsa050100.63249133
88Vibrio cholerae infection_Homo sapiens_hsa051100.63063147
89Hippo signaling pathway_Homo sapiens_hsa043900.62177719
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61532711
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60705621
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.60494985
93Calcium signaling pathway_Homo sapiens_hsa040200.60208468
94PPAR signaling pathway_Homo sapiens_hsa033200.60205401
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59450962
96Arginine biosynthesis_Homo sapiens_hsa002200.59311695
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59297650
98Parkinsons disease_Homo sapiens_hsa050120.58265158
99Renal cell carcinoma_Homo sapiens_hsa052110.58015675
100Choline metabolism in cancer_Homo sapiens_hsa052310.57923212
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57540611
102Pyruvate metabolism_Homo sapiens_hsa006200.57058804
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56065611
104ErbB signaling pathway_Homo sapiens_hsa040120.55191640
105Homologous recombination_Homo sapiens_hsa034400.54956664
106Metabolic pathways_Homo sapiens_hsa011000.54831899
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.54560072
108Wnt signaling pathway_Homo sapiens_hsa043100.53915593
109Tight junction_Homo sapiens_hsa045300.53550046
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53451522
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.53204236
112Protein export_Homo sapiens_hsa030600.53150970
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52817553
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52586000
115Carbon metabolism_Homo sapiens_hsa012000.52462889
116Retinol metabolism_Homo sapiens_hsa008300.51184452
117Ras signaling pathway_Homo sapiens_hsa040140.50959314
118Fatty acid degradation_Homo sapiens_hsa000710.50268397
119beta-Alanine metabolism_Homo sapiens_hsa004100.49702923
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49267813
121Oxytocin signaling pathway_Homo sapiens_hsa049210.48882530
122Chemical carcinogenesis_Homo sapiens_hsa052040.48310339
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48189540
124Endocytosis_Homo sapiens_hsa041440.47934914
125Lysosome_Homo sapiens_hsa041420.47148829
126Melanogenesis_Homo sapiens_hsa049160.46605921
127Linoleic acid metabolism_Homo sapiens_hsa005910.44139958
128Glycerolipid metabolism_Homo sapiens_hsa005610.43599752
129Glutathione metabolism_Homo sapiens_hsa004800.42706758
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42522771
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40558801
132Hedgehog signaling pathway_Homo sapiens_hsa043400.38346618
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36570547

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