TMEM229B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34746351
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34746351
3GMP metabolic process (GO:0046037)4.31335184
4COPI coating of Golgi vesicle (GO:0048205)4.29736175
5Golgi transport vesicle coating (GO:0048200)4.29736175
6sodium ion export (GO:0071436)3.95781279
7antigen processing and presentation of endogenous antigen (GO:0019883)3.87378593
8synaptic vesicle maturation (GO:0016188)3.77401808
9retinal rod cell development (GO:0046548)3.66904115
10positive regulation of gamma-delta T cell activation (GO:0046645)3.65084830
11negative regulation of lymphocyte mediated immunity (GO:0002707)3.58283186
12synaptic vesicle exocytosis (GO:0016079)3.54881808
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.53019855
14regulation of synaptic vesicle exocytosis (GO:2000300)3.49756069
15response to pheromone (GO:0019236)3.47518027
16detection of bacterium (GO:0016045)3.47391377
17detection of other organism (GO:0098543)3.44507172
18B cell receptor signaling pathway (GO:0050853)3.42325465
19regulation of ARF protein signal transduction (GO:0032012)3.36551049
20response to type I interferon (GO:0034340)3.33463278
21cellular response to type I interferon (GO:0071357)3.33098743
22type I interferon signaling pathway (GO:0060337)3.33098743
23macrophage activation involved in immune response (GO:0002281)3.31058821
24protein maturation by protein folding (GO:0022417)3.28784321
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.27166169
26negative regulation of T cell mediated immunity (GO:0002710)3.24397437
27cellular potassium ion homeostasis (GO:0030007)3.21363306
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18929969
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.18929969
30modulation by symbiont of host immune response (GO:0052553)3.18929969
31positive regulation by symbiont of host defense response (GO:0052509)3.18929969
32modulation by symbiont of host defense response (GO:0052031)3.18929969
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18929969
34negative regulation of leukocyte mediated immunity (GO:0002704)3.16801184
35insulin secretion (GO:0030073)3.09573129
36negative regulation of cell killing (GO:0031342)3.08261802
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08261802
38response to interleukin-15 (GO:0070672)3.08116504
39leukocyte aggregation (GO:0070486)3.07776455
40cellular response to interleukin-15 (GO:0071350)3.07400791
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99071061
42negative T cell selection (GO:0043383)2.98455477
43regulation of B cell receptor signaling pathway (GO:0050855)2.98130349
44regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97131189
45negative thymic T cell selection (GO:0045060)2.95399415
46negative regulation of calcium ion transport into cytosol (GO:0010523)2.92200296
47regulation of synaptic vesicle transport (GO:1902803)2.88573824
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86862343
49regulation of T cell mediated cytotoxicity (GO:0001914)2.86749275
50negative regulation of glycoprotein biosynthetic process (GO:0010561)2.81973328
51adaptation of signaling pathway (GO:0023058)2.81938617
52axon cargo transport (GO:0008088)2.80774897
53T cell selection (GO:0045058)2.79289010
54immunoglobulin mediated immune response (GO:0016064)2.77807170
55positive regulation of B cell differentiation (GO:0045579)2.75721594
56germinal center formation (GO:0002467)2.73304677
57negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.69807802
58detection of external biotic stimulus (GO:0098581)2.69622867
59interferon-gamma-mediated signaling pathway (GO:0060333)2.69317082
60retinal cone cell development (GO:0046549)2.68747072
61mast cell activation (GO:0045576)2.68617949
62anterograde axon cargo transport (GO:0008089)2.67821931
63neutrophil activation involved in immune response (GO:0002283)2.67372550
64detection of light stimulus involved in sensory perception (GO:0050962)2.67324122
65detection of light stimulus involved in visual perception (GO:0050908)2.67324122
66negative regulation of bone resorption (GO:0045779)2.67064294
67thymic T cell selection (GO:0045061)2.65111511
68regulation of T-helper 2 cell differentiation (GO:0045628)2.63064615
69nitric oxide mediated signal transduction (GO:0007263)2.62757633
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59571250
71potassium ion homeostasis (GO:0055075)2.57119408
72regulation of type B pancreatic cell apoptotic process (GO:2000674)2.53892550
73vesicle coating (GO:0006901)2.52574000
74neutrophil activation (GO:0042119)2.52327501
75signal peptide processing (GO:0006465)2.52314058
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50952683
77regulation of gamma-delta T cell differentiation (GO:0045586)2.50810117
78activated T cell proliferation (GO:0050798)2.48730555
79positive regulation of synapse maturation (GO:0090129)2.48509384
80lysosome localization (GO:0032418)2.47640403
81regulation of B cell differentiation (GO:0045577)2.46645171
82positive regulation of type 2 immune response (GO:0002830)2.46515690
83myeloid cell activation involved in immune response (GO:0002275)2.45514859
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45435665
85regulation of regulatory T cell differentiation (GO:0045589)2.45257243
86signal complex assembly (GO:0007172)2.43608888
87photoreceptor cell development (GO:0042461)2.42820423
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42726765
89regulation of mast cell degranulation (GO:0043304)2.41414629
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.40992223
91regulation of mast cell activation involved in immune response (GO:0033006)2.40979487
92regulation of interferon-beta biosynthetic process (GO:0045357)2.40837316
93mast cell activation involved in immune response (GO:0002279)2.40627091
94mast cell degranulation (GO:0043303)2.40627091
95endocrine pancreas development (GO:0031018)2.40557394
96regulation of defense response to virus by virus (GO:0050690)2.40102915
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.39219514
98microglial cell activation (GO:0001774)2.38538872
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38403296
100T cell migration (GO:0072678)2.36662448
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36297432
102locomotory exploration behavior (GO:0035641)2.35201218
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.35099507
104response to host immune response (GO:0052572)2.34997085
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34997085
106interferon-gamma secretion (GO:0072643)2.34233994
107antigen processing and presentation via MHC class Ib (GO:0002475)2.33938125
108tolerance induction (GO:0002507)2.33339242
109positive thymic T cell selection (GO:0045059)2.33284532
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33151144
111positive regulation of antigen processing and presentation (GO:0002579)2.32702912
112defense response to protozoan (GO:0042832)2.31482630
113cellular response to zinc ion (GO:0071294)2.31354563
114eye photoreceptor cell development (GO:0042462)2.31040021
115negative regulation of microtubule polymerization (GO:0031115)2.30851686
116regulation of T cell tolerance induction (GO:0002664)2.30491784
117peptide hormone processing (GO:0016486)2.30489826
118regulation of gamma-delta T cell activation (GO:0046643)2.30388954
119type B pancreatic cell development (GO:0003323)2.30073563
120establishment of synaptic vesicle localization (GO:0097480)2.30040764
121synaptic vesicle transport (GO:0048489)2.30040764
122negative regulation of type 2 immune response (GO:0002829)2.29834855
123macrophage activation (GO:0042116)2.29168974
124regulation of mast cell activation (GO:0033003)2.27748282
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.25847162
126regulation of leukocyte degranulation (GO:0043300)2.25757501
127cellular extravasation (GO:0045123)2.25385430
128negative regulation of innate immune response (GO:0045824)2.25046582
129production of molecular mediator involved in inflammatory response (GO:0002532)2.24594701
130regulation of cellular extravasation (GO:0002691)2.24500507
131response to peptidoglycan (GO:0032494)2.24217725
132regulation of type 2 immune response (GO:0002828)2.23774631
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.23715818
134leukocyte degranulation (GO:0043299)2.22641909
135L-amino acid import (GO:0043092)2.22486147
136detection of biotic stimulus (GO:0009595)2.22302881
137regulation of antigen processing and presentation (GO:0002577)2.22131190
138positive regulation of insulin secretion (GO:0032024)2.21456694
139granulocyte activation (GO:0036230)2.21287332
140regulation of insulin secretion (GO:0050796)2.20805157
141regulation of ARF GTPase activity (GO:0032312)2.20671144
142potassium ion import (GO:0010107)2.19598806
143nerve growth factor signaling pathway (GO:0038180)2.19067280
144regulation of alpha-beta T cell proliferation (GO:0046640)2.18831284
145regulation of leukocyte mediated cytotoxicity (GO:0001910)2.17740128
146regulation of tolerance induction (GO:0002643)2.17171994
147neuron cell-cell adhesion (GO:0007158)2.16862559
148negative regulation of adaptive immune response (GO:0002820)2.16836119
149interferon-gamma production (GO:0032609)2.16483491
150positive regulation of exocytosis (GO:0045921)2.16337886
151respiratory burst (GO:0045730)2.15834224
152glandular epithelial cell differentiation (GO:0002067)2.15536860
153sequestering of metal ion (GO:0051238)2.15173272
154regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.14597069
155positive regulation of regulated secretory pathway (GO:1903307)2.14050637
156antigen receptor-mediated signaling pathway (GO:0050851)2.12310663
157cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11186140
158regulation of regulated secretory pathway (GO:1903305)2.10294071
159detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.10030255
160detection of temperature stimulus involved in sensory perception (GO:0050961)2.10030255
161response to host (GO:0075136)2.09901001
162response to host defenses (GO:0052200)2.09901001
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.09901001
164negative regulation of phagocytosis (GO:0050765)2.09741308
165neutrophil mediated immunity (GO:0002446)2.09283177
166establishment of mitochondrion localization (GO:0051654)2.09233187
167positive regulation of Rap GTPase activity (GO:0032854)2.08855196
168intra-Golgi vesicle-mediated transport (GO:0006891)2.08365734
169protein localization to synapse (GO:0035418)2.08082164
170positive T cell selection (GO:0043368)2.08062155
171regulation of pigment cell differentiation (GO:0050932)2.07418984
172regulation of neuron projection regeneration (GO:0070570)2.07281356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.49059967
2* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24484283
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.84650186
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81718569
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74876466
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67968196
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.60698455
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37832314
9VDR_21846776_ChIP-Seq_THP-1_Human2.37723532
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19058054
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18999792
12SPI1_23127762_ChIP-Seq_K562_Human2.14753836
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.14552718
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13408004
15CIITA_25753668_ChIP-Seq_RAJI_Human2.09631902
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02211902
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01367700
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99263239
19MYB_26560356_Chip-Seq_TH2_Human1.92792763
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92729569
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91880239
22RUNX_20019798_ChIP-Seq_JUKART_Human1.91509575
23SCL_19346495_ChIP-Seq_HPC-7_Human1.91443017
24* IRF8_27001747_Chip-Seq_BMDM_Mouse1.89212131
25UTX_26944678_Chip-Seq_JUKART_Human1.88229588
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.88074990
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87199772
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85878797
29GATA1_22025678_ChIP-Seq_K562_Human1.85786064
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85532340
31* KDM2B_26808549_Chip-Seq_DND41_Human1.83932075
32SPI1_23547873_ChIP-Seq_NB4_Human1.82920344
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.82428306
34VDR_24763502_ChIP-Seq_THP-1_Human1.79969685
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75701527
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73507534
37* GATA3_27048872_Chip-Seq_THYMUS_Human1.71618307
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.70656562
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68659570
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.68239000
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68053829
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68005718
43TCF7_22412390_ChIP-Seq_EML_Mouse1.66758250
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66424579
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65701950
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65344013
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64949877
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64507402
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61894899
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.60512496
51EZH2_22144423_ChIP-Seq_EOC_Human1.58179290
52MYB_26560356_Chip-Seq_TH1_Human1.54391184
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.51965908
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50687792
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.50636872
56MAF_26560356_Chip-Seq_TH1_Human1.48797418
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.46127025
58VDR_24787735_ChIP-Seq_THP-1_Human1.44298648
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42894247
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42747435
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.38360460
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36486680
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36411273
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31840589
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28978320
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.26040853
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25317615
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24465252
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24384099
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22143867
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.20083206
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19971182
73* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19559305
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18756345
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15608665
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14333222
77* GATA3_26560356_Chip-Seq_TH2_Human1.14275943
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14175748
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14018259
80DROSHA_22980978_ChIP-Seq_HELA_Human1.13794461
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13215685
82* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12750432
83E2F7_22180533_ChIP-Seq_HELA_Human1.11760402
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11489647
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08152612
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07742024
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07722897
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.05399216
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.05016467
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04989922
91BCL6_27268052_Chip-Seq_Bcells_Human1.04749582
92BCOR_27268052_Chip-Seq_Bcells_Human1.04747355
93ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04130803
94* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04020078
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03270391
96IGF1R_20145208_ChIP-Seq_DFB_Human1.02903578
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02267996
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01134624
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00868881
100MAF_26560356_Chip-Seq_TH2_Human1.00310261
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.99680352
102* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98459010
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98243350
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97908402
105GATA1_19941826_ChIP-Seq_K562_Human0.97344844
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97030530
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96674170
108KDM5A_27292631_Chip-Seq_BREAST_Human0.96388220
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95287644
110SMC4_20622854_ChIP-Seq_HELA_Human0.94705744
111OCT4_19829295_ChIP-Seq_ESCs_Human0.94267862
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91976285
113PU_27001747_Chip-Seq_BMDM_Mouse0.91863724
114AHR_22903824_ChIP-Seq_MCF-7_Human0.91113679
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.90715318
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90639919
117LXR_22292898_ChIP-Seq_THP-1_Human0.90611194
118* SMRT_27268052_Chip-Seq_Bcells_Human0.90322640
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90317465
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90123953
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89558173
122* ARNT_22903824_ChIP-Seq_MCF-7_Human0.89412843
123KDM2B_26808549_Chip-Seq_K562_Human0.89375433
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89314288
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89304989
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87648589
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87367325
128ZNF274_21170338_ChIP-Seq_K562_Hela0.86545895
129AR_21572438_ChIP-Seq_LNCaP_Human0.86325391
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85134143
131GBX2_23144817_ChIP-Seq_PC3_Human0.85057119
132P68_20966046_ChIP-Seq_HELA_Human0.84878737
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84073663
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83089317
135* RUNX1_27514584_Chip-Seq_MCF-7_Human0.83087443
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82700699
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82571248
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82245817
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81885544
140GATA2_19941826_ChIP-Seq_K562_Human0.81514517
141BP1_19119308_ChIP-ChIP_Hs578T_Human0.80743660
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78542878
143STAT1_20625510_ChIP-Seq_HELA_Human0.77672322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.68390702
2MP0002909_abnormal_adrenal_gland2.85452181
3MP0006072_abnormal_retinal_apoptosis2.50101274
4MP0003303_peritoneal_inflammation2.40612426
5MP0006082_CNS_inflammation2.38759308
6MP0004381_abnormal_hair_follicle2.31657582
7MP0002638_abnormal_pupillary_reflex2.27450379
8MP0003183_abnormal_peptide_metabolism2.25784995
9MP0001835_abnormal_antigen_presentation2.23325945
10MP0005551_abnormal_eye_electrophysiolog2.20137697
11MP0003172_abnormal_lysosome_physiology2.19652690
12MP0001986_abnormal_taste_sensitivity2.15929488
13MP0002693_abnormal_pancreas_physiology2.04489297
14MP0005075_abnormal_melanosome_morpholog1.96635840
15MP0001501_abnormal_sleep_pattern1.90776908
16MP0005671_abnormal_response_to1.86850501
17MP0001800_abnormal_humoral_immune1.86663161
18MP0004859_abnormal_synaptic_plasticity1.85322259
19MP0003879_abnormal_hair_cell1.78815033
20MP0003635_abnormal_synaptic_transmissio1.78762332
21MP0003329_amyloid_beta_deposits1.78432663
22MP0000015_abnormal_ear_pigmentation1.75082883
23MP0009785_altered_susceptibility_to1.74677957
24MP0005423_abnormal_somatic_nervous1.74233247
25MP0001502_abnormal_circadian_rhythm1.73781320
26MP0003690_abnormal_glial_cell1.73117772
27MP0005409_darkened_coat_color1.70616606
28MP0003191_abnormal_cellular_cholesterol1.67019530
29MP0005253_abnormal_eye_physiology1.66983659
30MP0003787_abnormal_imprinting1.66695008
31MP0004270_analgesia1.66603805
32MP0001790_abnormal_immune_system1.65628203
33MP0005387_immune_system_phenotype1.65628203
34MP0010386_abnormal_urinary_bladder1.62959026
35MP0003300_gastrointestinal_ulcer1.62896143
36MP0001944_abnormal_pancreas_morphology1.61295661
37MP0005000_abnormal_immune_tolerance1.59518758
38MP0010155_abnormal_intestine_physiology1.58812836
39MP0002723_abnormal_immune_serum1.57054287
40MP0003866_abnormal_defecation1.56668588
41MP0002734_abnormal_mechanical_nocicepti1.56659286
42MP0002420_abnormal_adaptive_immunity1.55658537
43MP0002877_abnormal_melanocyte_morpholog1.55178836
44MP0002398_abnormal_bone_marrow1.54997801
45MP0005174_abnormal_tail_pigmentation1.54561596
46MP0000013_abnormal_adipose_tissue1.53785957
47MP0001819_abnormal_immune_cell1.53068850
48MP0005310_abnormal_salivary_gland1.52252887
49MP0002452_abnormal_antigen_presenting1.50845275
50MP0002733_abnormal_thermal_nociception1.44982002
51MP0003763_abnormal_thymus_physiology1.43052714
52MP0008569_lethality_at_weaning1.42224254
53MP0000465_gastrointestinal_hemorrhage1.41950433
54MP0005379_endocrine/exocrine_gland_phen1.41493745
55MP0001533_abnormal_skeleton_physiology1.40557906
56MP0001970_abnormal_pain_threshold1.38687072
57MP0002735_abnormal_chemical_nociception1.38562129
58MP0000716_abnormal_immune_system1.35570281
59MP0001188_hyperpigmentation1.35314019
60MP0002229_neurodegeneration1.34611117
61MP0002396_abnormal_hematopoietic_system1.33376086
62MP0005058_abnormal_lysosome_morphology1.31510825
63MP0002272_abnormal_nervous_system1.30879901
64MP0004858_abnormal_nervous_system1.30809485
65MP0002064_seizures1.29859973
66MP0009046_muscle_twitch1.25981787
67MP0002090_abnormal_vision1.25140477
68MP0008260_abnormal_autophagy1.25017378
69MP0002063_abnormal_learning/memory/cond1.23729828
70MP0003045_fibrosis1.22107026
71MP0001845_abnormal_inflammatory_respons1.21500552
72MP0005645_abnormal_hypothalamus_physiol1.20346614
73MP0009780_abnormal_chondrocyte_physiolo1.18771050
74MP0000685_abnormal_immune_system1.18593055
75MP0000920_abnormal_myelination1.18554757
76MP0008961_abnormal_basal_metabolism1.15953176
77MP0002405_respiratory_system_inflammati1.15938951
78MP0004885_abnormal_endolymph1.15474760
79MP0004043_abnormal_pH_regulation1.14150751
80MP0000604_amyloidosis1.13955261
81MP0005025_abnormal_response_to1.13174004
82MP0002184_abnormal_innervation1.13049130
83MP0001873_stomach_inflammation1.12576510
84MP0002419_abnormal_innate_immunity1.12162492
85MP0004811_abnormal_neuron_physiology1.11653627
86MP0000703_abnormal_thymus_morphology1.10751865
87MP0002095_abnormal_skin_pigmentation1.10590956
88MP0005464_abnormal_platelet_physiology1.07613689
89MP0002067_abnormal_sensory_capabilities1.07523331
90MP0002572_abnormal_emotion/affect_behav1.06353963
91MP0002429_abnormal_blood_cell1.05435460
92MP0000955_abnormal_spinal_cord1.04764369
93MP0000689_abnormal_spleen_morphology1.04279201
94MP0009333_abnormal_splenocyte_physiolog1.03595420
95MP0009278_abnormal_bone_marrow1.03153324
96MP0001984_abnormal_olfaction1.02437640
97MP0002722_abnormal_immune_system1.01343444
98MP0001486_abnormal_startle_reflex1.00945084
99MP0002148_abnormal_hypersensitivity_rea1.00445605
100MP0001968_abnormal_touch/_nociception0.97494976
101MP0005166_decreased_susceptibility_to0.97310529
102MP0003075_altered_response_to0.95835033
103MP0008469_abnormal_protein_level0.95463303
104MP0009764_decreased_sensitivity_to0.95390712
105MP0001851_eye_inflammation0.94643113
106MP0005220_abnormal_exocrine_pancreas0.93679607
107MP0003634_abnormal_glial_cell0.93085758
108MP0000569_abnormal_digit_pigmentation0.92788183
109MP0002882_abnormal_neuron_morphology0.90932558
110MP0001765_abnormal_ion_homeostasis0.90597847
111MP0002166_altered_tumor_susceptibility0.89797877
112MP0003436_decreased_susceptibility_to0.89761357
113MP0006276_abnormal_autonomic_nervous0.89317016
114MP0003880_abnormal_central_pattern0.88670805
115MP0005535_abnormal_body_temperature0.88197212
116MP0008874_decreased_physiological_sensi0.88128103
117MP0005167_abnormal_blood-brain_barrier0.85801504
118MP0004510_myositis0.84540413
119MP0000631_abnormal_neuroendocrine_gland0.82747598
120MP0002078_abnormal_glucose_homeostasis0.82663107
121MP0001664_abnormal_digestion0.82371905
122MP0003283_abnormal_digestive_organ0.82029711
123MP0009745_abnormal_behavioral_response0.81542602
124MP0003633_abnormal_nervous_system0.80040605
125MP0005195_abnormal_posterior_eye0.80039849
126MP0002557_abnormal_social/conspecific_i0.77129829
127MP0004947_skin_inflammation0.77040951
128MP0009840_abnormal_foam_cell0.76898819
129MP0005171_absent_coat_pigmentation0.75533429
130MP0002653_abnormal_ependyma_morphology0.75408300
131MP0003878_abnormal_ear_physiology0.74802696
132MP0005377_hearing/vestibular/ear_phenot0.74802696
133MP0010329_abnormal_lipoprotein_level0.74431436
134MP0005408_hypopigmentation0.73945541
135MP0002998_abnormal_bone_remodeling0.73682177

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.37497835
2Congenital stationary night blindness (HP:0007642)4.34457341
3Abnormal rod and cone electroretinograms (HP:0008323)4.09057189
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.07029243
5Orchitis (HP:0100796)4.00801848
6Visual hallucinations (HP:0002367)3.93526084
7Optic neuritis (HP:0100653)3.88640067
8Retrobulbar optic neuritis (HP:0100654)3.88640067
9Stomatitis (HP:0010280)3.84377532
10Bony spicule pigmentary retinopathy (HP:0007737)3.63905906
11Papilledema (HP:0001085)3.63870350
12Abnormality of macrophages (HP:0004311)3.29184661
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.24307235
14Supranuclear gaze palsy (HP:0000605)3.16629453
15Mutism (HP:0002300)3.12594066
16Increased cerebral lipofuscin (HP:0011813)3.03635398
17Severe visual impairment (HP:0001141)3.00772284
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.00498049
19Chronic otitis media (HP:0000389)2.96621536
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.85912153
21Recurrent viral infections (HP:0004429)2.85238755
22Gingivitis (HP:0000230)2.77228206
23Gastrointestinal infarctions (HP:0005244)2.74803225
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71240527
25Recurrent bronchitis (HP:0002837)2.70523400
26Ocular albinism (HP:0001107)2.68743121
27Loss of speech (HP:0002371)2.68226748
28Encephalitis (HP:0002383)2.68126096
29IgM deficiency (HP:0002850)2.66659381
30Vasculitis (HP:0002633)2.65434759
31Recurrent gram-negative bacterial infections (HP:0005420)2.65124429
32Agammaglobulinemia (HP:0004432)2.62566607
33Focal motor seizures (HP:0011153)2.60605510
34Recurrent bacterial skin infections (HP:0005406)2.60436084
35Focal seizures (HP:0007359)2.58040872
36Nasal polyposis (HP:0100582)2.55357296
37Recurrent abscess formation (HP:0002722)2.51799113
38Keratoconjunctivitis sicca (HP:0001097)2.47769233
39Hemiplegia (HP:0002301)2.46664905
40Dysostosis multiplex (HP:0000943)2.43427346
41Keratoconjunctivitis (HP:0001096)2.42559675
42Constricted visual fields (HP:0001133)2.40270532
43Hemoptysis (HP:0002105)2.39802011
44Pulmonary infiltrates (HP:0002113)2.38380598
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37794966
46Episodic fever (HP:0001954)2.35161610
47Panhypogammaglobulinemia (HP:0003139)2.35110318
48Postural instability (HP:0002172)2.32892169
49Agitation (HP:0000713)2.31769758
50Diminished motivation (HP:0000745)2.30845876
51Chronic obstructive pulmonary disease (HP:0006510)2.30614629
52Obstructive lung disease (HP:0006536)2.30614629
53Apathy (HP:0000741)2.30028897
54T lymphocytopenia (HP:0005403)2.29921411
55Truncal ataxia (HP:0002078)2.29890480
56B lymphocytopenia (HP:0010976)2.29869111
57Abnormality of B cell number (HP:0010975)2.29869111
58Febrile seizures (HP:0002373)2.27155799
59Recurrent fungal infections (HP:0002841)2.26842210
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24560274
61Abnormality of macular pigmentation (HP:0008002)2.23901005
62Chest pain (HP:0100749)2.23281278
63Amyotrophic lateral sclerosis (HP:0007354)2.22380172
64Iris hypopigmentation (HP:0007730)2.20083043
65Pustule (HP:0200039)2.18548279
66Congenital sensorineural hearing impairment (HP:0008527)2.18538949
67Cellulitis (HP:0100658)2.18504359
68Thyroiditis (HP:0100646)2.17051168
69Myokymia (HP:0002411)2.16695054
70Disinhibition (HP:0000734)2.16595577
71Peripheral hypomyelination (HP:0007182)2.14834809
72Chronic sinusitis (HP:0011109)2.14218808
73Papilloma (HP:0012740)2.13934621
74Verrucae (HP:0200043)2.13934621
75Central scotoma (HP:0000603)2.12897058
76Abnormality of T cell physiology (HP:0011840)2.12107843
77Type II diabetes mellitus (HP:0005978)2.12007118
78Meningitis (HP:0001287)2.11895964
79Urinary glycosaminoglycan excretion (HP:0003541)2.11267098
80Mucopolysacchariduria (HP:0008155)2.11267098
81Hypoplasia of the thymus (HP:0000778)2.10722813
82Abnormality of the nasal mucosa (HP:0000433)2.09585705
83Fatigue (HP:0012378)2.08218346
84Vertigo (HP:0002321)2.07982557
85Hypochromic anemia (HP:0001931)2.07079287
86Stomach cancer (HP:0012126)2.06716845
87Large for gestational age (HP:0001520)2.06520062
88Progressive cerebellar ataxia (HP:0002073)2.06393395
89Abnormality of T cells (HP:0002843)2.04879023
90Hypochromic microcytic anemia (HP:0004840)2.04796521
91Abnormality of T cell number (HP:0011839)2.03565160
92Leukocytosis (HP:0001974)2.03396343
93Elevated erythrocyte sedimentation rate (HP:0003565)2.03001885
94Increased CSF protein (HP:0002922)2.02283533
95Ventricular fibrillation (HP:0001663)2.01160709
96Inappropriate behavior (HP:0000719)2.00774139
97Hypoglycemic seizures (HP:0002173)2.00344136
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99013665
99Abnormality of polysaccharide metabolism (HP:0011012)1.99013665
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99013665
101Decreased circulating renin level (HP:0003351)1.98325192
102Hyperacusis (HP:0010780)1.98197247
103Slow saccadic eye movements (HP:0000514)1.97319499
104Prolonged bleeding time (HP:0003010)1.97145095
105Progressive neurologic deterioration (HP:0002344)1.94381625
106Absence seizures (HP:0002121)1.93606809
107Recurrent cutaneous fungal infections (HP:0011370)1.93369725
108Chronic mucocutaneous candidiasis (HP:0002728)1.93369725
109Macroorchidism (HP:0000053)1.92163532
110Neuronal loss in central nervous system (HP:0002529)1.90987361
111Insulin-resistant diabetes mellitus (HP:0000831)1.90292513
112Ankle clonus (HP:0011448)1.89044407
113Urticaria (HP:0001025)1.88004290
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.87778758
115Genetic anticipation (HP:0003743)1.87579714
116Epileptic encephalopathy (HP:0200134)1.87121955
117Absent/shortened dynein arms (HP:0200106)1.86811298
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.86811298
119Pulmonary embolism (HP:0002204)1.86479565
120EEG with generalized epileptiform discharges (HP:0011198)1.86253224
121Abnormality of the fingertips (HP:0001211)1.85854904
122Decreased central vision (HP:0007663)1.85651996
123Symptomatic seizures (HP:0011145)1.84961293
124Abnormality of glycolipid metabolism (HP:0010969)1.84889068
125Abnormality of liposaccharide metabolism (HP:0010968)1.84889068
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.84889068
127Impaired smooth pursuit (HP:0007772)1.84240716
128Malnutrition (HP:0004395)1.84107371
129Action tremor (HP:0002345)1.84071623
130Joint swelling (HP:0001386)1.83792957
131Osteomyelitis (HP:0002754)1.83446048
132Amyloidosis (HP:0011034)1.82818471
133Increased IgE level (HP:0003212)1.82435974
134Spastic gait (HP:0002064)1.82063996
135Colitis (HP:0002583)1.79951224
136Acne (HP:0001061)1.79843382
137Gastrointestinal inflammation (HP:0004386)1.79771965
138Gingival bleeding (HP:0000225)1.79339817
139Spontaneous hematomas (HP:0007420)1.78894013
140Abnormality of binocular vision (HP:0011514)1.78255798
141Diplopia (HP:0000651)1.78255798
142Neurofibrillary tangles (HP:0002185)1.77764569
143Attenuation of retinal blood vessels (HP:0007843)1.77642860
144Pendular nystagmus (HP:0012043)1.77499917
145Inflammation of the large intestine (HP:0002037)1.75413032
146Lymphopenia (HP:0001888)1.74711851
147Recurrent skin infections (HP:0001581)1.74087901
148Sepsis (HP:0100806)1.73771701
149Epileptiform EEG discharges (HP:0011182)1.73368809
150Excessive salivation (HP:0003781)1.73248150
151Drooling (HP:0002307)1.73248150
152Interstitial pulmonary disease (HP:0006530)1.73180825
153Depression (HP:0000716)1.71376555
154Eczematoid dermatitis (HP:0000976)1.71151694
155Mediastinal lymphadenopathy (HP:0100721)1.70701780
156Bronchitis (HP:0012387)1.70361698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.55461881
2PASK3.31519451
3MAP4K13.10754022
4INSRR2.98636246
5TAOK32.73801769
6HIPK22.53599789
7SCYL22.53225869
8EEF2K2.03612521
9FES2.00225273
10MAP3K111.97338363
11BLK1.92660214
12SIK21.79762954
13SYK1.79613342
14TYK21.71037888
15DAPK21.70860603
16FRK1.66382531
17KIT1.64378155
18RIPK41.61830270
19MINK11.52031686
20MAP3K91.50700961
21CAMKK21.47139607
22MAP3K101.46327222
23BTK1.43818169
24STK381.42184057
25IRAK41.41924965
26SIK31.36115968
27NTRK31.33987827
28EPHA41.32777869
29GRK61.32271626
30RPS6KA21.24744420
31CLK11.22043119
32MAP3K31.20699712
33PAK61.19640282
34EPHA31.16925077
35FLT31.16721389
36CSNK1G21.16184159
37PKN21.13073250
38NEK61.12213058
39MAPK131.11982979
40MAPK151.11936316
41ITK1.11503782
42NTRK11.10463661
43EPHB11.10414677
44ZAP701.10379446
45JAK11.09334254
46CSF1R1.07902555
47CAMKK11.07161227
48ERN11.05947733
49PDPK11.05037401
50RIPK11.04223419
51ALK1.03140992
52NTRK21.02382236
53CSNK1G31.02029977
54PRKCH1.00804118
55FGFR40.98794824
56TXK0.98704705
57DYRK30.98236136
58TEC0.96498567
59BRSK10.95867410
60PRPF4B0.95606310
61UHMK10.94655863
62MAP2K30.93260414
63DYRK1A0.91454187
64MARK30.90896557
65CSNK1A1L0.89786470
66CDK50.88296854
67PRKD20.88225444
68NEK20.88010876
69LCK0.87197495
70MAPK120.86516796
71JAK30.84587110
72WNK10.83950685
73MARK20.83904635
74HCK0.82896187
75BUB10.81901348
76MAP2K20.79618535
77BRSK20.79453792
78DYRK1B0.79144348
79MAP3K130.78336833
80BRD40.76893952
81CASK0.75718228
82PRKAA10.73523244
83SGK20.73073659
84TESK20.72161432
85FGR0.71092051
86LYN0.70736773
87JAK20.69893100
88KSR20.68846903
89SGK30.68420637
90IKBKB0.67244610
91DYRK20.66674822
92RET0.66335835
93MAP3K140.65703140
94MAP3K120.65597904
95MAPK90.64411617
96MAP3K20.64266989
97TYRO30.62445244
98PRKCZ0.61209863
99PRKD30.60730705
100RPS6KA40.59958851
101PTK2B0.59840251
102FGFR30.59339902
103MAP2K40.58653518
104FER0.58495804
105MAPK70.58260102
106TBK10.58142696
107TRIB30.57898339
108ERBB30.57609709
109MAPK40.57478734
110STK110.55660221
111MAP3K40.55495447
112TNK20.54163508
113IRAK10.52649112
114MAP2K70.51506362
115TAOK10.51243540
116PINK10.51092581
117SGK2230.51057049
118SGK4940.51057049
119BMPR20.51034247
120PKN10.50670698
121YES10.50663373
122IRAK20.49932848
123MAP3K70.49466423
124PTK60.49089529
125FYN0.49067398
126GRK50.48395793
127PAK30.47389774
128PHKG20.47350658
129PHKG10.47350658
130PRKCQ0.46072826
131MAP3K10.45721654
132CSK0.45565170
133PDK10.43473867
134CSNK1G10.43445504
135STK160.43106464
136CDK190.43036081
137RPS6KB10.39189383
138RPS6KA60.38629567
139MATK0.37842492
140IKBKE0.37683950
141CAMK1G0.36917021
142TNIK0.35069872

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.89198259
2Synaptic vesicle cycle_Homo sapiens_hsa047212.00398385
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98807332
4Insulin secretion_Homo sapiens_hsa049111.90953254
5Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88488640
6B cell receptor signaling pathway_Homo sapiens_hsa046621.82740688
7Graft-versus-host disease_Homo sapiens_hsa053321.81448221
8Primary immunodeficiency_Homo sapiens_hsa053401.76184368
9Protein export_Homo sapiens_hsa030601.71127669
10Allograft rejection_Homo sapiens_hsa053301.69767197
11Phototransduction_Homo sapiens_hsa047441.67342684
12Type II diabetes mellitus_Homo sapiens_hsa049301.63826752
13Autoimmune thyroid disease_Homo sapiens_hsa053201.61497027
14Lysosome_Homo sapiens_hsa041421.48861659
15N-Glycan biosynthesis_Homo sapiens_hsa005101.45635260
16Morphine addiction_Homo sapiens_hsa050321.44349383
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43325041
18GABAergic synapse_Homo sapiens_hsa047271.42199656
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41891667
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40481821
21Staphylococcus aureus infection_Homo sapiens_hsa051501.40352147
22Circadian entrainment_Homo sapiens_hsa047131.40043165
23Nicotine addiction_Homo sapiens_hsa050331.36793560
24Long-term potentiation_Homo sapiens_hsa047201.35191569
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32261221
26Cholinergic synapse_Homo sapiens_hsa047251.29532033
27Dopaminergic synapse_Homo sapiens_hsa047281.25065456
28Antigen processing and presentation_Homo sapiens_hsa046121.23762977
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23643778
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19642535
31Other glycan degradation_Homo sapiens_hsa005111.19492977
32Olfactory transduction_Homo sapiens_hsa047401.18628064
33Regulation of autophagy_Homo sapiens_hsa041401.18247825
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13016089
35Glutamatergic synapse_Homo sapiens_hsa047241.11947021
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.09060337
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08667072
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07839523
39T cell receptor signaling pathway_Homo sapiens_hsa046601.06380336
40Type I diabetes mellitus_Homo sapiens_hsa049401.04949880
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.04656436
42Chemokine signaling pathway_Homo sapiens_hsa040621.04472701
43Long-term depression_Homo sapiens_hsa047301.03228099
44Cocaine addiction_Homo sapiens_hsa050301.02645422
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01219541
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00796288
47Osteoclast differentiation_Homo sapiens_hsa043801.00475822
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99876413
49Amphetamine addiction_Homo sapiens_hsa050310.99228269
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99173393
51mTOR signaling pathway_Homo sapiens_hsa041500.98260963
52Hepatitis C_Homo sapiens_hsa051600.97818185
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96875795
54Serotonergic synapse_Homo sapiens_hsa047260.93011953
55Influenza A_Homo sapiens_hsa051640.91259634
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91073729
57Colorectal cancer_Homo sapiens_hsa052100.91065241
58Taste transduction_Homo sapiens_hsa047420.90321387
59Toxoplasmosis_Homo sapiens_hsa051450.90294108
60Prolactin signaling pathway_Homo sapiens_hsa049170.88597433
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87634355
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86595516
63TNF signaling pathway_Homo sapiens_hsa046680.85901891
64Circadian rhythm_Homo sapiens_hsa047100.85481867
65Leishmaniasis_Homo sapiens_hsa051400.83453351
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82580753
67Estrogen signaling pathway_Homo sapiens_hsa049150.82426602
68Chronic myeloid leukemia_Homo sapiens_hsa052200.82388660
69Tuberculosis_Homo sapiens_hsa051520.82136108
70Salivary secretion_Homo sapiens_hsa049700.81812017
71Vibrio cholerae infection_Homo sapiens_hsa051100.81371558
72Renal cell carcinoma_Homo sapiens_hsa052110.81032960
73Inositol phosphate metabolism_Homo sapiens_hsa005620.80790637
74Non-small cell lung cancer_Homo sapiens_hsa052230.80340097
75ABC transporters_Homo sapiens_hsa020100.80088171
76Renin secretion_Homo sapiens_hsa049240.80078621
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79444791
78Dorso-ventral axis formation_Homo sapiens_hsa043200.79128022
79Endocytosis_Homo sapiens_hsa041440.78012961
80Asthma_Homo sapiens_hsa053100.77341068
81VEGF signaling pathway_Homo sapiens_hsa043700.77304444
82Ovarian steroidogenesis_Homo sapiens_hsa049130.77191448
83Pancreatic cancer_Homo sapiens_hsa052120.76486518
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76480704
85Alcoholism_Homo sapiens_hsa050340.74670861
86Oxytocin signaling pathway_Homo sapiens_hsa049210.74356220
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74267653
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74086400
89Viral myocarditis_Homo sapiens_hsa054160.73781977
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73432443
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73220221
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73125399
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.72896195
94African trypanosomiasis_Homo sapiens_hsa051430.72258122
95Calcium signaling pathway_Homo sapiens_hsa040200.72253092
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72015156
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70482042
98Glioma_Homo sapiens_hsa052140.70009456
99Endometrial cancer_Homo sapiens_hsa052130.69710994
100Measles_Homo sapiens_hsa051620.69155433
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68037852
102Collecting duct acid secretion_Homo sapiens_hsa049660.68000720
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.67429342
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.66884179
105Herpes simplex infection_Homo sapiens_hsa051680.66880114
106Pancreatic secretion_Homo sapiens_hsa049720.66696165
107Hepatitis B_Homo sapiens_hsa051610.65635359
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65176557
109Gap junction_Homo sapiens_hsa045400.64626588
110Acute myeloid leukemia_Homo sapiens_hsa052210.63856230
111Oocyte meiosis_Homo sapiens_hsa041140.60034180
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.59981330
113Gastric acid secretion_Homo sapiens_hsa049710.59594075
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.59111739
115GnRH signaling pathway_Homo sapiens_hsa049120.58173777
116cAMP signaling pathway_Homo sapiens_hsa040240.57785936
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.57110455
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56398553
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.56070210
120Platelet activation_Homo sapiens_hsa046110.54678546
121Phagosome_Homo sapiens_hsa041450.53683056
122Epstein-Barr virus infection_Homo sapiens_hsa051690.53564718
123MAPK signaling pathway_Homo sapiens_hsa040100.53227913
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52330304
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.51762213
126Hematopoietic cell lineage_Homo sapiens_hsa046400.50602305
127ErbB signaling pathway_Homo sapiens_hsa040120.49246299
128Choline metabolism in cancer_Homo sapiens_hsa052310.48978121
129Insulin resistance_Homo sapiens_hsa049310.48705135

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