TMEM230

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.37868484
2proteasome assembly (GO:0043248)4.67768139
3DNA deamination (GO:0045006)4.27723793
4L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.08004340
5L-phenylalanine metabolic process (GO:0006558)3.97559299
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97559299
7L-phenylalanine catabolic process (GO:0006559)3.94077401
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94077401
9protein deneddylation (GO:0000338)3.89928553
10regulation of mitochondrial translation (GO:0070129)3.89906710
11branched-chain amino acid catabolic process (GO:0009083)3.88724425
12metallo-sulfur cluster assembly (GO:0031163)3.87902505
13iron-sulfur cluster assembly (GO:0016226)3.87902505
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84476187
15negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.77605600
16response to interferon-beta (GO:0035456)3.77397838
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77040230
18COPI coating of Golgi vesicle (GO:0048205)3.64932566
19Golgi transport vesicle coating (GO:0048200)3.64932566
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63212980
21signal peptide processing (GO:0006465)3.56266379
22cullin deneddylation (GO:0010388)3.50228857
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.48443708
24attachment of spindle microtubules to kinetochore (GO:0008608)3.47211498
25piRNA metabolic process (GO:0034587)3.42532793
26xenobiotic catabolic process (GO:0042178)3.40785343
27GMP metabolic process (GO:0046037)3.40777205
28protein neddylation (GO:0045116)3.39258061
29respiratory electron transport chain (GO:0022904)3.38550541
30aldehyde catabolic process (GO:0046185)3.33041669
31electron transport chain (GO:0022900)3.31537665
32GDP-mannose metabolic process (GO:0019673)3.29525128
33endosome to melanosome transport (GO:0035646)3.29448733
34endosome to pigment granule transport (GO:0043485)3.29448733
35L-methionine salvage (GO:0071267)3.29142899
36L-methionine biosynthetic process (GO:0071265)3.29142899
37amino acid salvage (GO:0043102)3.29142899
38oxidative phosphorylation (GO:0006119)3.27255646
39GPI anchor biosynthetic process (GO:0006506)3.24999887
40platelet dense granule organization (GO:0060155)3.23553315
41meiotic chromosome segregation (GO:0045132)3.22005763
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19151637
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15989380
44ATP synthesis coupled proton transport (GO:0015986)3.14743293
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14743293
46branched-chain amino acid metabolic process (GO:0009081)3.11069913
47cellular response to interferon-beta (GO:0035458)3.10432188
48ribosomal small subunit assembly (GO:0000028)3.08222115
49C-terminal protein lipidation (GO:0006501)3.07763280
50aminoglycoside antibiotic metabolic process (GO:0030647)3.07358412
51daunorubicin metabolic process (GO:0044597)3.05910584
52polyketide metabolic process (GO:0030638)3.05910584
53doxorubicin metabolic process (GO:0044598)3.05910584
54telomere maintenance via semi-conservative replication (GO:0032201)3.05128850
55purine-containing compound salvage (GO:0043101)3.02263190
56regulation of cholesterol esterification (GO:0010872)3.01484476
57purine nucleobase biosynthetic process (GO:0009113)3.00666135
58maturation of 5.8S rRNA (GO:0000460)2.99689835
59tricarboxylic acid cycle (GO:0006099)2.97735198
60regulation of cellular amino acid metabolic process (GO:0006521)2.95772485
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95541666
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.95508505
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92443032
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92443032
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92443032
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91141395
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91141395
68telomere maintenance via recombination (GO:0000722)2.90701660
69misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.90449113
70single strand break repair (GO:0000012)2.89689081
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89550841
72regulation of helicase activity (GO:0051095)2.88928443
73respiratory chain complex IV assembly (GO:0008535)2.88270989
74protein targeting to mitochondrion (GO:0006626)2.87866055
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.82598686
76GPI anchor metabolic process (GO:0006505)2.80315053
77positive regulation of actin filament depolymerization (GO:0030836)2.80210704
78production of molecular mediator involved in inflammatory response (GO:0002532)2.79586921
79ribosome assembly (GO:0042255)2.78062618
80regulation of cellular amine metabolic process (GO:0033238)2.77409779
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76690422
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75570914
83signal transduction involved in DNA damage checkpoint (GO:0072422)2.75570914
84chaperone-mediated protein transport (GO:0072321)2.74859429
85ribosomal large subunit biogenesis (GO:0042273)2.74340000
86mitochondrial respiratory chain complex assembly (GO:0033108)2.73532945
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72971468
88signal transduction involved in cell cycle checkpoint (GO:0072395)2.72079311
89deoxyribonucleotide biosynthetic process (GO:0009263)2.70296395
90guanosine-containing compound biosynthetic process (GO:1901070)2.70088260
91cell redox homeostasis (GO:0045454)2.69996747
92antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.69604697
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.69556212
94cytochrome complex assembly (GO:0017004)2.68635953
95rRNA modification (GO:0000154)2.68277460
96methionine biosynthetic process (GO:0009086)2.67864996
97deoxyribose phosphate biosynthetic process (GO:0046385)2.67502787
982-deoxyribonucleotide biosynthetic process (GO:0009265)2.67502787
99chromatin remodeling at centromere (GO:0031055)2.66319224
100CENP-A containing nucleosome assembly (GO:0034080)2.66089014
101dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.65464318
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65381595
103C-terminal protein amino acid modification (GO:0018410)2.65080796
104quinone metabolic process (GO:1901661)2.64741745
105deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.64092397
106nucleoside salvage (GO:0043174)2.62957809
107blood coagulation, intrinsic pathway (GO:0007597)2.61640621
108response to interferon-alpha (GO:0035455)2.61593252
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61483375
110negative regulation of ligase activity (GO:0051352)2.61483375
111neutrophil activation involved in immune response (GO:0002283)2.61103707
112positive regulation of cell cycle arrest (GO:0071158)2.60373048
113nucleotide-sugar biosynthetic process (GO:0009226)2.59785590
114galactose catabolic process (GO:0019388)2.59644794
115rRNA methylation (GO:0031167)2.58909153
116establishment of protein localization to mitochondrion (GO:0072655)2.57896751
117DNA methylation involved in gamete generation (GO:0043046)2.57697681
118water-soluble vitamin biosynthetic process (GO:0042364)2.57329876
119regulation of ligase activity (GO:0051340)2.57011141
120mannosylation (GO:0097502)2.56354327
1217-methylguanosine mRNA capping (GO:0006370)2.54973754
122cellular aldehyde metabolic process (GO:0006081)2.54812947
123AMP metabolic process (GO:0046033)2.54205440
124aerobic respiration (GO:0009060)2.52948560
125mitochondrial DNA replication (GO:0006264)2.52587889
126regulation of metalloenzyme activity (GO:0048552)2.51546907
127glyoxylate metabolic process (GO:0046487)2.49941155
128RNA capping (GO:0036260)2.49816749
1297-methylguanosine RNA capping (GO:0009452)2.49816749
130mitotic recombination (GO:0006312)2.47769816
131preassembly of GPI anchor in ER membrane (GO:0016254)2.47328995
132cellular metabolic compound salvage (GO:0043094)2.46341695
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.46075047
134metaphase plate congression (GO:0051310)2.45912230
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44953481
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.44240430
137fat-soluble vitamin biosynthetic process (GO:0042362)2.44181822
138protein complex biogenesis (GO:0070271)2.43394184
139positive regulation of ligase activity (GO:0051351)2.42979970
140DNA strand elongation involved in DNA replication (GO:0006271)2.42048456
141DNA strand elongation (GO:0022616)2.41176436
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40028988
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40028988
144regulation of RIG-I signaling pathway (GO:0039535)2.38863648
145nucleobase biosynthetic process (GO:0046112)2.38063167
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.36333016
147termination of RNA polymerase III transcription (GO:0006386)2.36333016
148mitotic metaphase plate congression (GO:0007080)2.34917376
149phagocytosis, engulfment (GO:0006911)2.34815653
150cellular response to thyroid hormone stimulus (GO:0097067)2.33433646
151leukocyte mediated cytotoxicity (GO:0001909)2.32934525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71415578
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.41674103
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.38486846
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25530777
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.94252240
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.91498122
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84261710
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.81068272
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73313942
10E2F7_22180533_ChIP-Seq_HELA_Human2.70496511
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.66703509
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63011226
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49706216
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.46572862
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46052356
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45821469
17VDR_23849224_ChIP-Seq_CD4+_Human2.45777974
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43977776
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40831752
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35319098
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.33527389
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31199186
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30332408
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25879541
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24678912
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.23752604
27HOXB4_20404135_ChIP-ChIP_EML_Mouse2.20120389
28DCP1A_22483619_ChIP-Seq_HELA_Human2.19342706
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14800895
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08506142
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01809732
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00693706
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00246042
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93522724
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92024719
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89802501
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87176956
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86928704
39ELK1_19687146_ChIP-ChIP_HELA_Human1.86054242
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81403415
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.79505664
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78566271
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78040142
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.73804429
45FOXP3_21729870_ChIP-Seq_TREG_Human1.73731952
46GABP_19822575_ChIP-Seq_HepG2_Human1.69808051
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69264663
48SPI1_23547873_ChIP-Seq_NB4_Human1.56254866
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55636164
50XRN2_22483619_ChIP-Seq_HELA_Human1.54221215
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.53365199
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52536402
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52176700
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48713388
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47671556
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45533744
57CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.44800907
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42393418
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40865693
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40460597
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40179948
62AR_21909140_ChIP-Seq_LNCAP_Human1.38993778
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38708906
64TFEB_21752829_ChIP-Seq_HELA_Human1.38457094
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33588633
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33412976
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.29947740
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29148943
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28849288
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22443089
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20000473
72TTF2_22483619_ChIP-Seq_HELA_Human1.19932286
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19906045
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19898192
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18751156
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18698319
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18614934
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18287959
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16596995
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16550689
81MYC_18940864_ChIP-ChIP_HL60_Human1.15271277
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.14590683
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12107036
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11569427
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.10318894
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09998651
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09052553
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08897786
89AR_20517297_ChIP-Seq_VCAP_Human1.07962099
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07958690
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.06531689
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06378033
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05097627
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04603215
95GATA1_22025678_ChIP-Seq_K562_Human1.04397205
96HTT_18923047_ChIP-ChIP_STHdh_Human1.03971866
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.03558597
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02204043
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02058220
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01599436
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01126137
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00982163
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00672090
104ZNF274_21170338_ChIP-Seq_K562_Hela0.97734851
105IRF8_27001747_Chip-Seq_BMDM_Mouse0.97636379
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96980168
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.96621833
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96455059
109ZNF263_19887448_ChIP-Seq_K562_Human0.96272949
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94569210
111FOXM1_23109430_ChIP-Seq_U2OS_Human0.94480299
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93078424
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92371340
114FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91841437
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.91841437
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90918922
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90026084
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88994977
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88883289
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88539034
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88351884
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88030871
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86284341
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85881980
125EOMES_21245162_ChIP-Seq_HESCs_Human0.85836641
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85705826
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85534937
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84781809
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84122513
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82993429
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.82325088
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80371535
133NANOG_19829295_ChIP-Seq_ESCs_Human0.80221060
134SOX2_19829295_ChIP-Seq_ESCs_Human0.80221060
135ERG_20517297_ChIP-Seq_VCAP_Human0.79480612
136IGF1R_20145208_ChIP-Seq_DFB_Human0.79069829
137GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77024269
138TP53_22573176_ChIP-Seq_HFKS_Human0.76908043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.84831767
2MP0002139_abnormal_hepatobiliary_system3.68954552
3MP0006054_spinal_hemorrhage3.67702158
4MP0003693_abnormal_embryo_hatching3.03068746
5MP0003186_abnormal_redox_activity2.96431445
6MP0005360_urolithiasis2.94353092
7MP0009697_abnormal_copulation2.86824115
8MP0000372_irregular_coat_pigmentation2.63658265
9MP0002148_abnormal_hypersensitivity_rea2.62034932
10MP0001835_abnormal_antigen_presentation2.58480937
11MP0005365_abnormal_bile_salt2.55773182
12MP0004782_abnormal_surfactant_physiolog2.54585175
13MP0008058_abnormal_DNA_repair2.52272278
14MP0009785_altered_susceptibility_to2.51244627
15MP0001986_abnormal_taste_sensitivity2.49807056
16MP0008438_abnormal_cutaneous_collagen2.38455157
17MP0005332_abnormal_amino_acid2.37408626
18MP0002876_abnormal_thyroid_physiology2.35671806
19MP0008875_abnormal_xenobiotic_pharmacok2.32792637
20MP0003656_abnormal_erythrocyte_physiolo2.29961420
21MP0010329_abnormal_lipoprotein_level2.27759332
22MP0005085_abnormal_gallbladder_physiolo2.19637908
23MP0010094_abnormal_chromosome_stability2.19068416
24MP0003436_decreased_susceptibility_to2.18255614
25MP0005058_abnormal_lysosome_morphology2.11170363
26MP0003195_calcinosis2.01189606
27MP0005670_abnormal_white_adipose2.00453827
28MP0003950_abnormal_plasma_membrane1.96932132
29MP0004957_abnormal_blastocyst_morpholog1.96058530
30MP0004147_increased_porphyrin_level1.93509482
31MP0010368_abnormal_lymphatic_system1.89900044
32MP0005084_abnormal_gallbladder_morpholo1.88936228
33MP0008007_abnormal_cellular_replicative1.85070602
34MP0001661_extended_life_span1.82204854
35MP0006036_abnormal_mitochondrial_physio1.79827652
36MP0000013_abnormal_adipose_tissue1.79175045
37MP0002396_abnormal_hematopoietic_system1.78742097
38MP0009780_abnormal_chondrocyte_physiolo1.75019300
39MP0002234_abnormal_pharynx_morphology1.73104831
40MP0006082_CNS_inflammation1.71532832
41MP0003077_abnormal_cell_cycle1.70438274
42MP0004272_abnormal_basement_membrane1.69929550
43MP0009840_abnormal_foam_cell1.66664439
44MP0002419_abnormal_innate_immunity1.65975902
45MP0001666_abnormal_nutrient_absorption1.65294600
46MP0005000_abnormal_immune_tolerance1.60041878
47MP0002405_respiratory_system_inflammati1.58214955
48MP0005025_abnormal_response_to1.56899354
49MP0003011_delayed_dark_adaptation1.51606641
50MP0002452_abnormal_antigen_presenting1.47665414
51MP0005671_abnormal_response_to1.42946832
52MP0002723_abnormal_immune_serum1.42890539
53MP0003786_premature_aging1.41687574
54MP0000343_altered_response_to1.41606434
55MP0003868_abnormal_feces_composition1.38946600
56MP0003718_maternal_effect1.38523921
57MP0004019_abnormal_vitamin_homeostasis1.37767400
58MP0005636_abnormal_mineral_homeostasis1.36939764
59MP0001800_abnormal_humoral_immune1.35326792
60MP0002163_abnormal_gland_morphology1.33591321
61MP0002938_white_spotting1.32380164
62MP0003252_abnormal_bile_duct1.32052733
63MP0002420_abnormal_adaptive_immunity1.31608628
64MP0000689_abnormal_spleen_morphology1.31542260
65MP0001819_abnormal_immune_cell1.30761105
66MP0009333_abnormal_splenocyte_physiolog1.29038448
67MP0001756_abnormal_urination1.28799892
68MP0003724_increased_susceptibility_to1.28420684
69MP0008469_abnormal_protein_level1.25702226
70MP0000490_abnormal_crypts_of1.25486043
71MP0001984_abnormal_olfaction1.24451428
72MP0002118_abnormal_lipid_homeostasis1.24150775
73MP0001764_abnormal_homeostasis1.22011297
74MP0000358_abnormal_cell_content/1.19050902
75MP0005464_abnormal_platelet_physiology1.18226070
76MP0000639_abnormal_adrenal_gland1.18095000
77MP0009764_decreased_sensitivity_to1.18034757
78MP0005551_abnormal_eye_electrophysiolog1.16630455
79MP0003943_abnormal_hepatobiliary_system1.16507244
80MP0002132_abnormal_respiratory_system1.15642857
81MP0002398_abnormal_bone_marrow1.15147848
82MP0008260_abnormal_autophagy1.15080701
83MP0001545_abnormal_hematopoietic_system1.15031065
84MP0005397_hematopoietic_system_phenotyp1.15031065
85MP0001845_abnormal_inflammatory_respons1.14611467
86MP0000716_abnormal_immune_system1.14572385
87MP0008877_abnormal_DNA_methylation1.14183279
88MP0004134_abnormal_chest_morphology1.13743228
89MP0008932_abnormal_embryonic_tissue1.13717948
90MP0000685_abnormal_immune_system1.13151742
91MP0002722_abnormal_immune_system1.12964971
92MP0001533_abnormal_skeleton_physiology1.12599559
93MP0002210_abnormal_sex_determination1.12571577
94MP0009643_abnormal_urine_homeostasis1.12351482
95MP0001929_abnormal_gametogenesis1.11276168
96MP0001119_abnormal_female_reproductive1.10847088
97MP0001529_abnormal_vocalization1.09877063
98MP0005165_increased_susceptibility_to1.08729884
99MP0003763_abnormal_thymus_physiology1.07895309
100MP0003646_muscle_fatigue1.05982419
101MP0002429_abnormal_blood_cell1.05700206
102MP0002090_abnormal_vision1.05367032
103MP0005410_abnormal_fertilization1.05275682
104MP0008057_abnormal_DNA_replication1.05262156
105MP0002006_tumorigenesis1.04249989
106MP0001542_abnormal_bone_strength1.02234565
107MP0000003_abnormal_adipose_tissue1.02208097
108MP0005319_abnormal_enzyme/_coenzyme1.00586578
109MP0005257_abnormal_intraocular_pressure0.99790101
110MP0002009_preneoplasia0.96609017
111MP0006035_abnormal_mitochondrial_morpho0.96553774
112MP0005503_abnormal_tendon_morphology0.95982213
113MP0003075_altered_response_to0.95926137
114MP0000609_abnormal_liver_physiology0.94949955
115MP0001145_abnormal_male_reproductive0.94105914
116MP0001790_abnormal_immune_system0.94061672
117MP0005387_immune_system_phenotype0.94061672
118MP0005390_skeleton_phenotype0.93621385
119MP0005253_abnormal_eye_physiology0.92427147
120MP0003111_abnormal_nucleus_morphology0.91933670
121MP0005330_cardiomyopathy0.91605576
122MP0000653_abnormal_sex_gland0.91012060
123MP0006072_abnormal_retinal_apoptosis0.90892973
124MP0000598_abnormal_liver_morphology0.90504993
125MP0000681_abnormal_thyroid_gland0.90427802
126MP0010155_abnormal_intestine_physiology0.89034653
127MP0002638_abnormal_pupillary_reflex0.88843821
128MP0002019_abnormal_tumor_incidence0.88728163
129MP0001853_heart_inflammation0.88171802
130MP0001905_abnormal_dopamine_level0.87230494
131MP0008775_abnormal_heart_ventricle0.86851003
132MP0004215_abnormal_myocardial_fiber0.86245594
133MP0002837_dystrophic_cardiac_calcinosis0.85895020
134MP0005584_abnormal_enzyme/coenzyme_acti0.85399882
135MP0008872_abnormal_physiological_respon0.84229266
136MP0002277_abnormal_respiratory_mucosa0.84003173
137MP0006292_abnormal_olfactory_placode0.83202711
138MP0005379_endocrine/exocrine_gland_phen0.80528168
139MP0010386_abnormal_urinary_bladder0.79863057
140MP0005367_renal/urinary_system_phenotyp0.77963947
141MP0000516_abnormal_urinary_system0.77963947
142MP0008004_abnormal_stomach_pH0.77643183
143MP0002166_altered_tumor_susceptibility0.77394923
144MP0002933_joint_inflammation0.76907278
145MP0002160_abnormal_reproductive_system0.76282646
146MP0004808_abnormal_hematopoietic_stem0.75692741
147MP0003191_abnormal_cellular_cholesterol0.75645744
148MP0005220_abnormal_exocrine_pancreas0.74118202
149MP0005075_abnormal_melanosome_morpholog0.71892658
150MP0005395_other_phenotype0.71755961
151MP0009763_increased_sensitivity_to0.71738751
152MP0003122_maternal_imprinting0.70954402
153MP0009642_abnormal_blood_homeostasis0.70928116
154MP0002909_abnormal_adrenal_gland0.69443949
155MP0005376_homeostasis/metabolism_phenot0.69355952
156MP0005408_hypopigmentation0.69092599
157MP0005166_decreased_susceptibility_to0.67787962
158MP0000858_altered_metastatic_potential0.67333058
159MP0005266_abnormal_metabolism0.66055494
160MP0003698_abnormal_male_reproductive0.64824022

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)3.82736217
2Degeneration of anterior horn cells (HP:0002398)3.82736217
3Acute necrotizing encephalopathy (HP:0006965)3.74107519
4Poor head control (HP:0002421)3.69827053
5Abnormal mitochondria in muscle tissue (HP:0008316)3.60017821
6Recurrent abscess formation (HP:0002722)3.53730731
7Acute encephalopathy (HP:0006846)3.51112571
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39142550
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39142550
10Progressive macrocephaly (HP:0004481)3.25093482
11Increased serum pyruvate (HP:0003542)3.23201671
12Generalized aminoaciduria (HP:0002909)3.22238554
13Hypothermia (HP:0002045)3.13587372
14Prolonged partial thromboplastin time (HP:0003645)3.11330232
15Recurrent bacterial skin infections (HP:0005406)3.09553381
16Type I transferrin isoform profile (HP:0003642)3.09238625
17Renal Fanconi syndrome (HP:0001994)2.98999898
18Abnormality of methionine metabolism (HP:0010901)2.94117375
19Abnormality of macular pigmentation (HP:0008002)2.93909777
20Abnormality of macrophages (HP:0004311)2.90259232
21Beaking of vertebral bodies (HP:0004568)2.89197718
22Cerebral edema (HP:0002181)2.87863122
23Abnormality of glycolysis (HP:0004366)2.85280268
24Methylmalonic acidemia (HP:0002912)2.84968933
25Abnormal spermatogenesis (HP:0008669)2.79731094
26Irregular epiphyses (HP:0010582)2.77415387
27Dicarboxylic aciduria (HP:0003215)2.76930838
28Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76930838
29Azoospermia (HP:0000027)2.76407458
30Respiratory failure (HP:0002878)2.76154434
31Hypoglycemic coma (HP:0001325)2.74256657
32Abnormal rod and cone electroretinograms (HP:0008323)2.72573222
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71982896
34Severe visual impairment (HP:0001141)2.69157848
35Congenital stationary night blindness (HP:0007642)2.67973962
36Abolished electroretinogram (ERG) (HP:0000550)2.67724249
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65515208
38Abnormal protein N-linked glycosylation (HP:0012347)2.65515208
39Abnormal protein glycosylation (HP:0012346)2.65515208
40Abnormal glycosylation (HP:0012345)2.65515208
41Vacuolated lymphocytes (HP:0001922)2.63765877
42Methylmalonic aciduria (HP:0012120)2.63070734
43Hypobetalipoproteinemia (HP:0003563)2.62921080
44Aplastic anemia (HP:0001915)2.59855468
45Exercise intolerance (HP:0003546)2.59457975
46Hepatic necrosis (HP:0002605)2.56085971
47Lethargy (HP:0001254)2.56033973
48Agnosia (HP:0010524)2.55125995
49True hermaphroditism (HP:0010459)2.53111436
50Acute myeloid leukemia (HP:0004808)2.51917583
51Tubulointerstitial nephritis (HP:0001970)2.50743458
52Exertional dyspnea (HP:0002875)2.50076064
53Glycosuria (HP:0003076)2.49871454
54Abnormality of urine glucose concentration (HP:0011016)2.49871454
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48057290
56Hepatocellular necrosis (HP:0001404)2.46694773
57Medial flaring of the eyebrow (HP:0010747)2.44487535
58Chronic otitis media (HP:0000389)2.42984954
59Abnormality of fatty-acid metabolism (HP:0004359)2.42866907
60Palpitations (HP:0001962)2.41248969
61Hyperglycinemia (HP:0002154)2.35708820
62Pancreatic fibrosis (HP:0100732)2.35112012
63Prolonged neonatal jaundice (HP:0006579)2.33648500
64CNS demyelination (HP:0007305)2.32872937
65Type 2 muscle fiber atrophy (HP:0003554)2.30457667
66Central scotoma (HP:0000603)2.25672754
67Spastic paraparesis (HP:0002313)2.25478179
68Rhabdomyolysis (HP:0003201)2.24372155
69Pancreatic cysts (HP:0001737)2.23564552
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21531705
71Hyperammonemia (HP:0001987)2.18466379
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15740237
73Poor coordination (HP:0002370)2.15694185
74Interstitial pulmonary disease (HP:0006530)2.14328896
75Opisthotonus (HP:0002179)2.13924810
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.12136070
77Bony spicule pigmentary retinopathy (HP:0007737)2.11860118
78Glucose intolerance (HP:0000833)2.11635868
79Nonprogressive disorder (HP:0003680)2.11017381
80Abnormality of the fovea (HP:0000493)2.09370660
81Respiratory difficulties (HP:0002880)2.08559067
82Abnormality of B cell number (HP:0010975)2.08057661
83B lymphocytopenia (HP:0010976)2.08057661
84Deep venous thrombosis (HP:0002625)2.06914817
85Hypoproteinemia (HP:0003075)2.05707818
86Carpal bone hypoplasia (HP:0001498)2.05090450
87Abnormality of serum amino acid levels (HP:0003112)2.04321249
88Reduced antithrombin III activity (HP:0001976)2.03932041
89Proximal tubulopathy (HP:0000114)2.03853130
90Congenital primary aphakia (HP:0007707)2.03222119
91Abnormality of vitamin B metabolism (HP:0004340)2.01642184
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01616027
93Patchy hypopigmentation of hair (HP:0011365)2.01331802
94Abnormality of glycine metabolism (HP:0010895)2.00735300
95Abnormality of serine family amino acid metabolism (HP:0010894)2.00735300
96Hypokinesia (HP:0002375)1.98365502
97Retinal dysplasia (HP:0007973)1.98288059
98Metaphyseal dysplasia (HP:0100255)1.98108183
99Nausea (HP:0002018)1.97673620
100Flat capital femoral epiphysis (HP:0003370)1.97404856
101Renal cortical cysts (HP:0000803)1.97222427
102Pancreatic islet-cell hyperplasia (HP:0004510)1.96475050
103IgM deficiency (HP:0002850)1.96236036
104Increased serum lactate (HP:0002151)1.96104775
105Abnormal pupillary function (HP:0007686)1.95510799
106Petechiae (HP:0000967)1.95299559
107Mitochondrial inheritance (HP:0001427)1.94497970
108Abnormality of the common coagulation pathway (HP:0010990)1.94234731
109Joint hemorrhage (HP:0005261)1.93478607
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.92796371
111Hypoplasia of the fovea (HP:0007750)1.92796371
112Cerebral palsy (HP:0100021)1.91542966
113Hyperglycinuria (HP:0003108)1.91328215
114Microretrognathia (HP:0000308)1.91215633
115Muscle fiber atrophy (HP:0100295)1.90123462
116Nephrogenic diabetes insipidus (HP:0009806)1.89740437
117Increased CSF lactate (HP:0002490)1.87298027
118Rough bone trabeculation (HP:0100670)1.86567476
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85717570
120Abnormality of alanine metabolism (HP:0010916)1.85717570
121Hyperalaninemia (HP:0003348)1.85717570
122Lipid accumulation in hepatocytes (HP:0006561)1.85610112
123Hyperglycemia (HP:0003074)1.85017868
124Vertebral compression fractures (HP:0002953)1.83565070
125Pancytopenia (HP:0001876)1.83518761
126Exercise-induced muscle cramps (HP:0003710)1.83212944
127Microvesicular hepatic steatosis (HP:0001414)1.83177648
128Progressive neurologic deterioration (HP:0002344)1.81962249
129Myoglobinuria (HP:0002913)1.81689360
130Emotional lability (HP:0000712)1.80999774
131Increased hepatocellular lipid droplets (HP:0006565)1.80955686
132Increased intramyocellular lipid droplets (HP:0012240)1.80177945
133Hyperphosphaturia (HP:0003109)1.80109065
134Sensorimotor neuropathy (HP:0007141)1.80073856
135Myositis (HP:0100614)1.79600361
136Stenosis of the external auditory canal (HP:0000402)1.79114356
137Increased IgM level (HP:0003496)1.78781230
1383-Methylglutaconic aciduria (HP:0003535)1.76885883
139Eczematoid dermatitis (HP:0000976)1.76677510
140Epiphyseal stippling (HP:0010655)1.76388564
141Abnormal gallbladder physiology (HP:0012438)1.75909186
142Cholecystitis (HP:0001082)1.75909186
143Gait imbalance (HP:0002141)1.75069676
144Pigmentary retinal degeneration (HP:0001146)1.74873069
145Genu varum (HP:0002970)1.74579017
146Postaxial foot polydactyly (HP:0001830)1.73884485
147Metabolic acidosis (HP:0001942)1.73631119
148Increased muscle lipid content (HP:0009058)1.70504969
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69870968
150Lactic acidosis (HP:0003128)1.69716671
151Elevated erythrocyte sedimentation rate (HP:0003565)1.69551269
152Vitreoretinal degeneration (HP:0000655)1.69439206
153Abnormality of the pons (HP:0007361)1.67627260
154Neoplasm of the adrenal gland (HP:0100631)1.67497894
155Birth length less than 3rd percentile (HP:0003561)1.67069225
156Granulocytopenia (HP:0001913)1.66402298
157Abnormal trabecular bone morphology (HP:0100671)1.66343271
158Dysostosis multiplex (HP:0000943)1.65789305
159Recurrent pneumonia (HP:0006532)1.65234269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.76334290
2STK163.78705464
3PBK3.48888774
4MAPKAPK33.23076867
5EIF2AK12.71820412
6ACVR1B2.57488763
7MYLK2.42717872
8VRK22.40593354
9WEE12.34540769
10BUB12.30765028
11TLK12.20346560
12MAP4K22.14807491
13FLT32.12826997
14TRIM282.01711063
15SCYL21.98973796
16NME21.89055384
17BRSK21.82431397
18PDK21.81436343
19NEK21.80859621
20PIM21.80599730
21EIF2AK31.77937500
22TXK1.70453462
23CDK191.68007865
24PLK41.66212358
25TEC1.65379387
26RPS6KB21.63362492
27MAP4K11.62140146
28TRPM71.61133629
29PRKG21.57846533
30MST41.52503504
31VRK11.51475846
32KIT1.51461641
33ARAF1.50309596
34MAPKAPK51.48476774
35BCR1.48285246
36ZAP701.42946275
37BCKDK1.32567600
38FRK1.30775380
39TESK11.25923721
40EEF2K1.25569985
41PAK41.25044921
42PIK3CA1.22410564
43CAMKK21.20278438
44IKBKE1.18470045
45ILK1.15315685
46MUSK1.14599697
47BRAF1.13622117
48RPS6KA41.13134206
49TYK21.12888865
50MAP3K141.12653289
51CDK81.12345957
52PLK21.12101345
53DAPK11.11526985
54TBK11.11249829
55PINK11.06641578
56TTK1.05925183
57CSNK1G31.02059548
58GRK11.00765008
59BMPR1B1.00391588
60MKNK10.97092866
61BMPR20.95349467
62ADRBK20.94813071
63LMTK20.91211005
64MOS0.90027192
65ZAK0.89883127
66CSNK1G10.89644623
67IRAK40.89282734
68PIK3CG0.89189049
69PASK0.88910587
70TNK20.88603588
71STK390.88141107
72JAK30.86510285
73NME10.84535729
74SIK30.83011528
75NEK90.82735536
76EIF2AK20.81195381
77CHEK20.80741226
78DAPK30.79776069
79NLK0.78246540
80DYRK30.77962919
81IKBKB0.75105073
82PLK10.74982378
83ERBB30.74678963
84CSNK1G20.74091235
85CSF1R0.73177400
86OXSR10.69509070
87TIE10.68699959
88STK40.68260931
89TGFBR20.67986972
90TESK20.67525005
91TAOK30.67097243
92SYK0.66954285
93LIMK10.66479453
94BTK0.64642558
95BRSK10.63897215
96CSNK1A1L0.63828118
97ATR0.62338457
98WNK40.61507800
99CDC70.60974907
100PHKG10.59219018
101PHKG20.59219018
102PIM10.58373911
103PLK30.58088289
104STK38L0.57562133
105MAP3K110.55940545
106MAPK150.55522637
107LYN0.55461559
108BLK0.55408407
109MAPK110.55018248
110TNIK0.54671002
111ERBB40.53561161
112PDK30.52928183
113PDK40.52928183
114CDK70.52913679
115WNK30.52678780
116STK30.52075703
117NUAK10.50835749
118CSNK2A10.50577569
119EPHA30.50562690
120MAP2K60.50429458
121MET0.50176794
122ABL20.50080235
123CHUK0.49986711
124FER0.49062441
125RAF10.48972860
126PRKCE0.48748175
127AURKA0.47933327
128PAK10.47928084
129MAP3K120.47401290
130AURKB0.46380588
131MKNK20.45428796
132RPS6KA50.45019170
133DYRK20.44784161
134STK240.44055470
135CCNB10.44008323
136CSNK2A20.43350209
137GRK70.43150063
138MAP3K50.42522172
139MST1R0.42079630
140PTK20.41982043
141KDR0.40669494
142EPHA20.39961699
143STK100.39053873
144SRPK10.37524452
145MINK10.37496335
146CAMK2D0.35491709
147IGF1R0.34549334
148GRK50.33366581

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.54196888
2Protein export_Homo sapiens_hsa030603.41425911
3DNA replication_Homo sapiens_hsa030303.10173962
4Mismatch repair_Homo sapiens_hsa034302.98523171
5RNA polymerase_Homo sapiens_hsa030202.53161699
6Homologous recombination_Homo sapiens_hsa034402.53142176
7Folate biosynthesis_Homo sapiens_hsa007902.48091367
8Non-homologous end-joining_Homo sapiens_hsa034502.41622741
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40534571
10Propanoate metabolism_Homo sapiens_hsa006402.35155001
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31297874
12Ribosome_Homo sapiens_hsa030102.28073706
13Pyrimidine metabolism_Homo sapiens_hsa002402.22863438
14Base excision repair_Homo sapiens_hsa034102.20704327
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03935930
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03878017
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.96266635
18Basal transcription factors_Homo sapiens_hsa030221.94401861
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92788119
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85018989
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.83224547
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81318106
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80158639
24Pyruvate metabolism_Homo sapiens_hsa006201.76154720
25Nucleotide excision repair_Homo sapiens_hsa034201.74971599
26RNA degradation_Homo sapiens_hsa030181.72816703
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.61486248
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.60209333
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58659291
30Fatty acid degradation_Homo sapiens_hsa000711.56378851
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49059764
32Purine metabolism_Homo sapiens_hsa002301.48845415
33Phototransduction_Homo sapiens_hsa047441.47966647
34Steroid biosynthesis_Homo sapiens_hsa001001.44876536
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44389752
36Vitamin B6 metabolism_Homo sapiens_hsa007501.39840257
37Cell cycle_Homo sapiens_hsa041101.38198419
38Fatty acid metabolism_Homo sapiens_hsa012121.37763442
39Butanoate metabolism_Homo sapiens_hsa006501.34382598
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34167651
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31963901
42RNA transport_Homo sapiens_hsa030131.29489794
43One carbon pool by folate_Homo sapiens_hsa006701.27884503
44Fanconi anemia pathway_Homo sapiens_hsa034601.27356773
45Complement and coagulation cascades_Homo sapiens_hsa046101.27052104
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25432663
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22288867
48Legionellosis_Homo sapiens_hsa051341.22016401
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20756171
50Oxidative phosphorylation_Homo sapiens_hsa001901.17955198
51Spliceosome_Homo sapiens_hsa030401.15135061
52Selenocompound metabolism_Homo sapiens_hsa004501.14580207
53Regulation of autophagy_Homo sapiens_hsa041401.12360318
54Lysosome_Homo sapiens_hsa041421.11482191
55Tyrosine metabolism_Homo sapiens_hsa003501.10722216
56Tryptophan metabolism_Homo sapiens_hsa003801.09925363
57Rheumatoid arthritis_Homo sapiens_hsa053231.08824752
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08760072
59beta-Alanine metabolism_Homo sapiens_hsa004101.07843338
60Parkinsons disease_Homo sapiens_hsa050121.06934885
61Other glycan degradation_Homo sapiens_hsa005111.04254285
62Sulfur relay system_Homo sapiens_hsa041221.03929656
63Phenylalanine metabolism_Homo sapiens_hsa003601.03770088
64Peroxisome_Homo sapiens_hsa041461.00467322
65p53 signaling pathway_Homo sapiens_hsa041150.96824111
66Arginine and proline metabolism_Homo sapiens_hsa003300.94886380
67Malaria_Homo sapiens_hsa051440.92611516
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.90398128
69Fatty acid elongation_Homo sapiens_hsa000620.89028950
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.88271223
71Fructose and mannose metabolism_Homo sapiens_hsa000510.88128126
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.87470880
73Herpes simplex infection_Homo sapiens_hsa051680.85849976
74Huntingtons disease_Homo sapiens_hsa050160.84468665
75Arginine biosynthesis_Homo sapiens_hsa002200.84018345
76Glutathione metabolism_Homo sapiens_hsa004800.81419551
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.81261668
78Pentose phosphate pathway_Homo sapiens_hsa000300.80912517
79Arachidonic acid metabolism_Homo sapiens_hsa005900.79537233
80N-Glycan biosynthesis_Homo sapiens_hsa005100.78988061
81Starch and sucrose metabolism_Homo sapiens_hsa005000.77279145
82PPAR signaling pathway_Homo sapiens_hsa033200.75861956
83Phagosome_Homo sapiens_hsa041450.74650586
84Fat digestion and absorption_Homo sapiens_hsa049750.72706894
85Galactose metabolism_Homo sapiens_hsa000520.72130570
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71915755
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69976093
88Chemical carcinogenesis_Homo sapiens_hsa052040.68684842
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66570241
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66381290
91Epstein-Barr virus infection_Homo sapiens_hsa051690.65406065
92Linoleic acid metabolism_Homo sapiens_hsa005910.65227638
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65137872
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64930691
95Vibrio cholerae infection_Homo sapiens_hsa051100.64141978
96Metabolic pathways_Homo sapiens_hsa011000.63864250
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63459650
98Leishmaniasis_Homo sapiens_hsa051400.62723911
99Shigellosis_Homo sapiens_hsa051310.60578105
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60320163
101Retinol metabolism_Homo sapiens_hsa008300.59516211
102Antigen processing and presentation_Homo sapiens_hsa046120.56374300
103Thyroid cancer_Homo sapiens_hsa052160.55673701
104Allograft rejection_Homo sapiens_hsa053300.53311824
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.51843206
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51842282
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51415783
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51345525
109Histidine metabolism_Homo sapiens_hsa003400.50793572
110Type I diabetes mellitus_Homo sapiens_hsa049400.50154124
111Hematopoietic cell lineage_Homo sapiens_hsa046400.49208094
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49136668
113Caffeine metabolism_Homo sapiens_hsa002320.48195149
114Renin-angiotensin system_Homo sapiens_hsa046140.47902835
115Measles_Homo sapiens_hsa051620.47794371
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46849545
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46456009
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45940376
119Primary immunodeficiency_Homo sapiens_hsa053400.44141458
120Influenza A_Homo sapiens_hsa051640.44056087
121Collecting duct acid secretion_Homo sapiens_hsa049660.43910581
122Sulfur metabolism_Homo sapiens_hsa009200.43572998
123Nitrogen metabolism_Homo sapiens_hsa009100.43355358
124Sphingolipid metabolism_Homo sapiens_hsa006000.42903436
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41933296
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41791725
127Asthma_Homo sapiens_hsa053100.41460299
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40778721
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39526962
130Alzheimers disease_Homo sapiens_hsa050100.38850064
131Biosynthesis of amino acids_Homo sapiens_hsa012300.38772078
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38265759
133Cardiac muscle contraction_Homo sapiens_hsa042600.37312337
134Carbon metabolism_Homo sapiens_hsa012000.37031604
135Staphylococcus aureus infection_Homo sapiens_hsa051500.36689658

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