TMEM233

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)6.74260195
2response to muscle activity (GO:0014850)6.55561868
3neurofilament cytoskeleton organization (GO:0060052)6.53521694
4regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)6.53073513
5actin-myosin filament sliding (GO:0033275)6.31204326
6muscle filament sliding (GO:0030049)6.31204326
7neuronal action potential (GO:0019228)6.29801820
8regulation of skeletal muscle contraction (GO:0014819)6.24958779
9detection of temperature stimulus (GO:0016048)6.01024370
10plasma membrane repair (GO:0001778)5.99086484
11skeletal muscle contraction (GO:0003009)5.98171260
12myofibril assembly (GO:0030239)5.88007372
13detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.85072752
14detection of temperature stimulus involved in sensory perception (GO:0050961)5.85072752
15neuronal action potential propagation (GO:0019227)5.77713454
16membrane depolarization during action potential (GO:0086010)5.52309883
17skeletal muscle adaptation (GO:0043501)5.40475462
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.35147517
19response to inactivity (GO:0014854)5.23908022
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.14879327
21actin-mediated cell contraction (GO:0070252)5.13365198
22regulation of cell communication by electrical coupling (GO:0010649)5.11479771
23muscle cell cellular homeostasis (GO:0046716)4.92555907
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.87053439
25glycogen catabolic process (GO:0005980)4.82174872
26muscle cell fate commitment (GO:0042693)4.76452982
27skeletal muscle tissue regeneration (GO:0043403)4.74677469
28purine nucleotide salvage (GO:0032261)4.55378683
29skeletal muscle tissue development (GO:0007519)4.52614635
30neuromuscular synaptic transmission (GO:0007274)4.50274119
31glucan catabolic process (GO:0009251)4.50155398
32negative regulation of protein localization to cell surface (GO:2000009)4.49305609
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.48887243
34cardiac myofibril assembly (GO:0055003)4.47440873
35behavioral response to pain (GO:0048266)4.40140078
36negative regulation of dendrite morphogenesis (GO:0050774)4.37338854
37carnitine shuttle (GO:0006853)4.35237379
38skeletal muscle fiber development (GO:0048741)4.32366733
39oxygen transport (GO:0015671)4.31627905
40cardiac muscle contraction (GO:0060048)4.30897432
41actomyosin structure organization (GO:0031032)4.16167761
42heart contraction (GO:0060047)4.12372043
43heart process (GO:0003015)4.12372043
44cellular polysaccharide catabolic process (GO:0044247)4.11652222
45regulation of actin filament-based movement (GO:1903115)4.10964702
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.97475647
47proline transport (GO:0015824)3.95818731
48striated muscle contraction (GO:0006941)3.95069533
49muscle organ morphogenesis (GO:0048644)3.94734552
50actin filament-based movement (GO:0030048)3.91966070
51positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.90363972
52response to activity (GO:0014823)3.89666204
53polysaccharide catabolic process (GO:0000272)3.88863707
54negative regulation of complement activation (GO:0045916)3.88721091
55response to pain (GO:0048265)3.84678170
56adenosine metabolic process (GO:0046085)3.78176734
57response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.75227933
58negative regulation of calcium ion transmembrane transport (GO:1903170)3.69281106
59negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.69281106
60myotube cell development (GO:0014904)3.69192831
61muscle organ development (GO:0007517)3.66964873
62muscle structure development (GO:0061061)3.66109943
63gas transport (GO:0015669)3.62728152
64muscle tissue morphogenesis (GO:0060415)3.62505612
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.59332575
66cell communication involved in cardiac conduction (GO:0086065)3.59075916
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.57899460
68fatty acid transmembrane transport (GO:1902001)3.53444462
69peripheral nervous system neuron development (GO:0048935)3.52733730
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.51881246
71urinary tract smooth muscle contraction (GO:0014848)3.51077468
72action potential (GO:0001508)3.50028863
73creatine metabolic process (GO:0006600)3.47991657
74axon cargo transport (GO:0008088)3.47925902
75myotube differentiation (GO:0014902)3.46480543
76muscle contraction (GO:0006936)3.45820389
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45130954
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.43797321
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41880844
80striated muscle adaptation (GO:0014888)3.39595292
81glycogen metabolic process (GO:0005977)3.39472122
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39373010
83positive regulation of cardiac muscle hypertrophy (GO:0010613)3.38160965
84positive regulation of muscle hypertrophy (GO:0014742)3.38160965
85muscle atrophy (GO:0014889)3.37933010
86sarcomere organization (GO:0045214)3.35468205
87cell migration in hindbrain (GO:0021535)3.33496910
88glucan metabolic process (GO:0044042)3.32300188
89cellular glucan metabolic process (GO:0006073)3.32300188
90positive regulation of sodium ion transmembrane transport (GO:1902307)3.32188382
91cellular potassium ion homeostasis (GO:0030007)3.30928537
92regulation of calcium ion transmembrane transport (GO:1903169)3.22072124
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22072124
94ubiquinone biosynthetic process (GO:0006744)3.20393468
95endoplasmic reticulum organization (GO:0007029)3.20113173
96negative regulation of protein activation cascade (GO:2000258)3.17237685
97cardiac muscle tissue morphogenesis (GO:0055008)3.16214056
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15936168
99regulation of relaxation of muscle (GO:1901077)3.15623685
100neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.15219814
101relaxation of muscle (GO:0090075)3.14636986
102synaptic transmission, cholinergic (GO:0007271)3.13717743
103regulation of striated muscle contraction (GO:0006942)3.13243769
104carnitine transmembrane transport (GO:1902603)3.11855029
105striated muscle tissue development (GO:0014706)3.09017804
106membrane repolarization (GO:0086009)3.07554065
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07135067
108negative regulation of calcium ion transport into cytosol (GO:0010523)3.07084210
109negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.07078385
110glycogen biosynthetic process (GO:0005978)3.06964920
111glucan biosynthetic process (GO:0009250)3.06964920
112response to ATP (GO:0033198)3.05663950
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05526176
114muscle system process (GO:0003012)3.03580230
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.03502936
116sodium ion export (GO:0071436)3.01898979
117enteric nervous system development (GO:0048484)3.01591888
118myoblast fusion (GO:0007520)3.01231924
119regulation of membrane repolarization (GO:0060306)3.00138413
120regulation of sodium ion transmembrane transporter activity (GO:2000649)2.98515749
121positive regulation of vesicle fusion (GO:0031340)2.98173606
122intermediate filament-based process (GO:0045103)2.98124485
123sodium ion transmembrane transport (GO:0035725)2.97145305
124myoblast migration (GO:0051451)2.97090298
125striated muscle atrophy (GO:0014891)2.96876576
126negative regulation of muscle contraction (GO:0045932)2.96419602
127striated muscle cell development (GO:0055002)2.96418723
128intermediate filament organization (GO:0045109)2.95242205
129regulation of histone phosphorylation (GO:0033127)2.95045613
130regulation of sequestering of triglyceride (GO:0010889)2.94379673
131negative regulation of cation channel activity (GO:2001258)2.94043218
132cardiac muscle hypertrophy (GO:0003300)2.93156352
133muscle fiber development (GO:0048747)2.92179489
134regulation of membrane depolarization (GO:0003254)2.91922586
135intermediate filament cytoskeleton organization (GO:0045104)2.91187568
136regulation of muscle system process (GO:0090257)2.91034497
137ubiquinone metabolic process (GO:0006743)2.90316906
138positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89488718
139regulation of muscle contraction (GO:0006937)2.88620834
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88109013
141detection of mechanical stimulus involved in sensory perception (GO:0050974)2.86752216
142regulation of sarcomere organization (GO:0060297)2.86268013
143regulation of sodium ion transmembrane transport (GO:1902305)2.85852534
144negative regulation of microtubule polymerization (GO:0031115)2.85174796
145DNA damage induced protein phosphorylation (GO:0006975)2.84341508
146potassium ion import (GO:0010107)2.83166174
147regulation of muscle hypertrophy (GO:0014743)2.83161538
148prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.81697239
149respiratory electron transport chain (GO:0022904)2.81163129
150regulation of the force of heart contraction (GO:0002026)2.80936760
151striated muscle hypertrophy (GO:0014897)2.80113654
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76613772
153electron transport chain (GO:0022900)2.76144470
154muscle tissue development (GO:0060537)2.76124210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.51009755
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.42470084
3ZNF263_19887448_ChIP-Seq_K562_Human3.00854129
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83808632
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.67490434
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63639906
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.61820911
8EZH2_22144423_ChIP-Seq_EOC_Human2.51962178
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.48077347
10GBX2_23144817_ChIP-Seq_PC3_Human2.42905056
11IGF1R_20145208_ChIP-Seq_DFB_Human2.40213364
12VDR_22108803_ChIP-Seq_LS180_Human2.37446906
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37406350
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19451061
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13944116
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06831428
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03025506
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95260681
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94987277
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94987277
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89199969
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87803025
23* CTCF_27219007_Chip-Seq_Bcells_Human1.87151145
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78229976
25AR_21572438_ChIP-Seq_LNCaP_Human1.76694946
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75754543
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74729011
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.69168884
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68094819
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.65624838
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.64763580
32* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.61775780
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.57807390
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.56964028
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56385217
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54445281
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.53694157
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.53121632
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.52329041
40ZNF274_21170338_ChIP-Seq_K562_Hela1.51947224
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50257346
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49253150
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48937025
44FUS_26573619_Chip-Seq_HEK293_Human1.48914409
45KDM2B_26808549_Chip-Seq_K562_Human1.47683071
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.46325042
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46093321
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44698495
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44016866
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43822060
51* REST_21632747_ChIP-Seq_MESCs_Mouse1.43135267
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.40607771
53DROSHA_22980978_ChIP-Seq_HELA_Human1.40217704
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.39079424
55EGR1_19032775_ChIP-ChIP_M12_Human1.38657316
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36770359
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36759357
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.36138360
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35936916
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32370577
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.31946616
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29595709
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27537102
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26938457
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26112921
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.24504655
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24079481
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23803430
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22342558
70SMAD4_21799915_ChIP-Seq_A2780_Human1.21779882
71CBP_20019798_ChIP-Seq_JUKART_Human1.21779702
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21779702
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21102037
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.21048073
75ER_23166858_ChIP-Seq_MCF-7_Human1.20994712
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20197318
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.19704057
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.19691735
79SA1_27219007_Chip-Seq_Bcells_Human1.19220449
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.18668297
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18472458
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.16944377
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14418383
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11982767
85KLF4_19829295_ChIP-Seq_ESCs_Human1.11737452
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.10661722
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09655636
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09543055
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.09391513
90HTT_18923047_ChIP-ChIP_STHdh_Human1.08981531
91P300_19829295_ChIP-Seq_ESCs_Human1.08132939
92GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.07827444
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06710976
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05872314
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05242881
96LXR_22292898_ChIP-Seq_THP-1_Human1.05175374
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05024626
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04897179
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04592931
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03566705
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.03363542
102KDM2B_26808549_Chip-Seq_DND41_Human1.03332904
103AHR_22903824_ChIP-Seq_MCF-7_Human1.02602099
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02207150
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01411901
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01373628
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00719777
108CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00411300
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.00267411
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99240365
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98865520
112KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98818039
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98623701
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.98588565
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.98588565
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97875908
117STAT1_20625510_ChIP-Seq_HELA_Human0.97432341
118* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96859612
119* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96775389
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.95946338
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95787294
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93375633
123OCT4_20526341_ChIP-Seq_ESCs_Human0.93297740
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.93005498
125* SMAD4_21741376_ChIP-Seq_EPCs_Human0.92428273
126P53_21459846_ChIP-Seq_SAOS-2_Human0.92345102
127SPI1_20517297_ChIP-Seq_HL60_Human0.91938903
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91646272
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91646272
130RNF2_27304074_Chip-Seq_NSC_Mouse0.91512425
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.91399094
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.91180631
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90801486
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90687207
135* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90312213
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89282799
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.89103930
138AR_19668381_ChIP-Seq_PC3_Human0.88665659
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88589966
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88514221
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87523891
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86857232
143MYC_27129775_Chip-Seq_CORNEA_Mouse0.86677768
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85392657
145* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85391460
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85359069
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84761974
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.83939152
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83260599
150BCAT_22108803_ChIP-Seq_LS180_Human0.83041655
151NANOG_19829295_ChIP-Seq_ESCs_Human0.82848718
152SOX2_19829295_ChIP-Seq_ESCs_Human0.82848718
153CJUN_26792858_Chip-Seq_BT549_Human0.82535211
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81979326
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81284414
156AR_25329375_ChIP-Seq_VCAP_Human0.80969678
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78377362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception5.97217470
2MP0002736_abnormal_nociception_after5.85560619
3MP0002735_abnormal_chemical_nociception5.79246321
4MP0004145_abnormal_muscle_electrophysio5.32584181
5MP0000749_muscle_degeneration4.36735716
6MP0004270_analgesia3.82203406
7MP0000751_myopathy3.69022938
8MP0001986_abnormal_taste_sensitivity3.67441689
9MP0003646_muscle_fatigue3.60381552
10MP0002733_abnormal_thermal_nociception3.32996862
11MP0000747_muscle_weakness3.32825332
12MP0004858_abnormal_nervous_system3.24626078
13MP0002734_abnormal_mechanical_nocicepti3.20731977
14MP0006276_abnormal_autonomic_nervous2.87894625
15MP0004036_abnormal_muscle_relaxation2.80712587
16MP0001970_abnormal_pain_threshold2.65722841
17MP0000759_abnormal_skeletal_muscle2.45607142
18MP0002106_abnormal_muscle_physiology2.45082026
19MP0002269_muscular_atrophy2.41902172
20MP0002837_dystrophic_cardiac_calcinosis2.39603009
21MP0004130_abnormal_muscle_cell2.37498231
22MP0003950_abnormal_plasma_membrane2.23639612
23MP0005451_abnormal_body_composition2.14210719
24MP0005369_muscle_phenotype2.03858229
25MP0005187_abnormal_penis_morphology1.99611546
26MP0004087_abnormal_muscle_fiber1.98096066
27MP0005620_abnormal_muscle_contractility1.93444274
28MP0003656_abnormal_erythrocyte_physiolo1.77024171
29MP0000750_abnormal_muscle_regeneration1.63907726
30MP0002272_abnormal_nervous_system1.61056417
31MP0005083_abnormal_biliary_tract1.59958414
32MP0004859_abnormal_synaptic_plasticity1.59007916
33MP0002067_abnormal_sensory_capabilities1.56732836
34MP0004885_abnormal_endolymph1.47378174
35MP0000372_irregular_coat_pigmentation1.45631061
36MP0004233_abnormal_muscle_weight1.43409323
37MP0004147_increased_porphyrin_level1.34599983
38MP0005266_abnormal_metabolism1.30363726
39MP0003329_amyloid_beta_deposits1.25073342
40MP0004043_abnormal_pH_regulation1.21594758
41MP0002184_abnormal_innervation1.15421525
42MP0006036_abnormal_mitochondrial_physio1.11605090
43MP0004811_abnormal_neuron_physiology1.10912927
44MP0002876_abnormal_thyroid_physiology1.10041104
45MP0002822_catalepsy1.09854264
46MP0001299_abnormal_eye_distance/1.09810145
47MP0002108_abnormal_muscle_morphology1.09764167
48MP0004185_abnormal_adipocyte_glucose1.07547587
49MP0002332_abnormal_exercise_endurance1.06645978
50MP0001270_distended_abdomen1.05135816
51MP0002127_abnormal_cardiovascular_syste1.03782011
52MP0006138_congestive_heart_failure1.00502752
53MP0002751_abnormal_autonomic_nervous0.99592589
54MP0003011_delayed_dark_adaptation0.99074914
55MP0002972_abnormal_cardiac_muscle0.98816556
56MP0000955_abnormal_spinal_cord0.98257393
57MP0004084_abnormal_cardiac_muscle0.95919127
58MP0003879_abnormal_hair_cell0.95800321
59MP0003806_abnormal_nucleotide_metabolis0.95722989
60MP0003635_abnormal_synaptic_transmissio0.95516378
61MP0000681_abnormal_thyroid_gland0.95249180
62MP0003045_fibrosis0.93960151
63MP0000733_abnormal_muscle_development0.93320805
64MP0009053_abnormal_anal_canal0.91271682
65MP0008260_abnormal_autophagy0.91051095
66MP0003880_abnormal_central_pattern0.85540445
67MP0004484_altered_response_of0.85029014
68MP0002234_abnormal_pharynx_morphology0.83746155
69MP0001348_abnormal_lacrimal_gland0.83497696
70MP0005330_cardiomyopathy0.82691403
71MP0003633_abnormal_nervous_system0.82596920
72MP0004215_abnormal_myocardial_fiber0.80324747
73MP0003283_abnormal_digestive_organ0.79190179
74MP0009046_muscle_twitch0.79119315
75MP0008569_lethality_at_weaning0.75422377
76MP0010368_abnormal_lymphatic_system0.73224843
77MP0010771_integument_phenotype0.69110218
78MP0002066_abnormal_motor_capabilities/c0.68956884
79MP0002909_abnormal_adrenal_gland0.67228010
80MP0005670_abnormal_white_adipose0.66808396
81MP0000003_abnormal_adipose_tissue0.66755421
82MP0005084_abnormal_gallbladder_morpholo0.65751401
83MP0002229_neurodegeneration0.64926536
84MP0000604_amyloidosis0.63541524
85MP0005595_abnormal_vascular_smooth0.63495664
86MP0002063_abnormal_learning/memory/cond0.63018181
87MP0008874_decreased_physiological_sensi0.62873489
88MP0000920_abnormal_myelination0.62857300
89MP0001879_abnormal_lymphatic_vessel0.62325632
90MP0002882_abnormal_neuron_morphology0.62224374
91MP0002064_seizures0.62121254
92MP0001661_extended_life_span0.60895306
93MP0010030_abnormal_orbit_morphology0.60588521
94MP0009745_abnormal_behavioral_response0.60531012
95MP0008961_abnormal_basal_metabolism0.60444070
96MP0004142_abnormal_muscle_tone0.60310844
97MP0001485_abnormal_pinna_reflex0.60152295
98MP0003631_nervous_system_phenotype0.59192442
99MP0005666_abnormal_adipose_tissue0.59007026
100MP0006035_abnormal_mitochondrial_morpho0.58282140
101MP0003828_pulmonary_edema0.57948592
102MP0003221_abnormal_cardiomyocyte_apopto0.57829741
103MP0008775_abnormal_heart_ventricle0.55297119
104MP0001486_abnormal_startle_reflex0.54784141
105MP0005423_abnormal_somatic_nervous0.54718562
106MP0003634_abnormal_glial_cell0.54247740
107MP0000767_abnormal_smooth_muscle0.51822368
108MP0002160_abnormal_reproductive_system0.51724475
109MP0000534_abnormal_ureter_morphology0.51466222
110MP0000427_abnormal_hair_cycle0.51214207
111MP0001984_abnormal_olfaction0.48629211
112MP0009250_abnormal_appendicular_skeleto0.48507306
113MP0005365_abnormal_bile_salt0.48353178
114MP0000013_abnormal_adipose_tissue0.48280906
115MP0005375_adipose_tissue_phenotype0.47994375
116MP0002971_abnormal_brown_adipose0.47672681
117MP0009780_abnormal_chondrocyte_physiolo0.46891677
118MP0002638_abnormal_pupillary_reflex0.46630402
119MP0000266_abnormal_heart_morphology0.45081798
120MP0001440_abnormal_grooming_behavior0.43440346
121MP0003137_abnormal_impulse_conducting0.43222978
122MP0005584_abnormal_enzyme/coenzyme_acti0.43167280
123MP0008872_abnormal_physiological_respon0.42115444
124MP0004085_abnormal_heartbeat0.41549448
125MP0005535_abnormal_body_temperature0.40180730
126MP0004134_abnormal_chest_morphology0.40150993
127MP0010630_abnormal_cardiac_muscle0.40081296
128MP0003195_calcinosis0.40001532
129MP0001188_hyperpigmentation0.39557724
130MP0005452_abnormal_adipose_tissue0.39136193
131MP0002752_abnormal_somatic_nervous0.38476489
132MP0001544_abnormal_cardiovascular_syste0.38405107
133MP0005385_cardiovascular_system_phenoty0.38405107
134MP0000230_abnormal_systemic_arterial0.38212213
135MP0000538_abnormal_urinary_bladder0.38178221
136MP0002572_abnormal_emotion/affect_behav0.36591656
137MP0004510_myositis0.35223765
138MP0010234_abnormal_vibrissa_follicle0.34795789
139MP0005645_abnormal_hypothalamus_physiol0.34681133
140MP0002128_abnormal_blood_circulation0.34590767
141MP0002078_abnormal_glucose_homeostasis0.34446282

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)7.20128714
2Exercise-induced myalgia (HP:0003738)6.92816057
3Muscle fiber inclusion bodies (HP:0100299)6.83307002
4Exercise-induced muscle cramps (HP:0003710)6.63631686
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.58406788
6Nemaline bodies (HP:0003798)6.14395706
7Ulnar claw (HP:0001178)5.99289896
8Muscle hypertrophy of the lower extremities (HP:0008968)5.41111017
9Hyporeflexia of lower limbs (HP:0002600)5.22324425
10Difficulty running (HP:0009046)5.07311601
11Myotonia (HP:0002486)4.95313918
12Myopathic facies (HP:0002058)4.94287516
13Absent phalangeal crease (HP:0006109)4.77925536
14Type 1 muscle fiber predominance (HP:0003803)4.76788185
15Muscle stiffness (HP:0003552)4.74949708
16Calf muscle hypertrophy (HP:0008981)4.63271104
17Round ear (HP:0100830)4.52581234
18Ulnar deviation of the wrist (HP:0003049)4.45840768
19Myoglobinuria (HP:0002913)4.37210290
20Segmental peripheral demyelination/remyelination (HP:0003481)4.23849673
21Muscle fiber splitting (HP:0003555)4.20164025
22Termporal pattern (HP:0011008)4.11338687
23Insidious onset (HP:0003587)4.11338687
24Abnormal finger flexion creases (HP:0006143)3.96869365
25EMG: myopathic abnormalities (HP:0003458)3.78573295
26Calcaneovalgus deformity (HP:0001848)3.73682188
27Increased connective tissue (HP:0009025)3.73150424
28Areflexia of lower limbs (HP:0002522)3.58751423
29Type 2 muscle fiber atrophy (HP:0003554)3.55225003
30Foot dorsiflexor weakness (HP:0009027)3.50409571
31Rhabdomyolysis (HP:0003201)3.43561357
32Weak cry (HP:0001612)3.40837362
33Centrally nucleated skeletal muscle fibers (HP:0003687)3.35785861
34Deformed tarsal bones (HP:0008119)3.35527904
35Dysautonomia (HP:0002459)3.33371376
36Fetal akinesia sequence (HP:0001989)3.29290895
37Steppage gait (HP:0003376)3.24614126
38Muscle fiber atrophy (HP:0100295)3.22763662
39Abnormality of the foot musculature (HP:0001436)3.17751513
40Action tremor (HP:0002345)3.13867965
41Abnormality of skeletal muscle fiber size (HP:0012084)3.12994452
42Difficulty climbing stairs (HP:0003551)3.11894586
43Popliteal pterygium (HP:0009756)3.10086650
44Pheochromocytoma (HP:0002666)3.09886999
45Impaired pain sensation (HP:0007328)3.08459317
46Abnormality of pain sensation (HP:0010832)3.08459317
47Increased variability in muscle fiber diameter (HP:0003557)3.01743227
48Abnormality of the calf musculature (HP:0001430)2.98165918
49Hammertoe (HP:0001765)2.85693512
50Gowers sign (HP:0003391)2.81697033
51Neuroendocrine neoplasm (HP:0100634)2.78171544
52Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.73203096
53EMG: neuropathic changes (HP:0003445)2.70717449
54Distal lower limb muscle weakness (HP:0009053)2.67396869
55Generalized muscle weakness (HP:0003324)2.66486340
56Ankle clonus (HP:0011448)2.65422288
57Frequent falls (HP:0002359)2.59371225
58Bulbar palsy (HP:0001283)2.55681142
59Onion bulb formation (HP:0003383)2.55220719
60Abnormality of the hip-girdle musculature (HP:0001445)2.53060286
61Abnormality of the musculature of the pelvis (HP:0001469)2.53060286
62Shoulder girdle muscle weakness (HP:0003547)2.52178751
63Impaired proprioception (HP:0010831)2.50562909
64Asymmetric septal hypertrophy (HP:0001670)2.50456560
65Hip contracture (HP:0003273)2.48231556
66Pelvic girdle muscle weakness (HP:0003749)2.47497357
67Abnormality of placental membranes (HP:0011409)2.45801820
68Amniotic constriction ring (HP:0009775)2.45801820
69Urinary urgency (HP:0000012)2.45471763
70Malignant hyperthermia (HP:0002047)2.43679156
71Abnormality of the left ventricular outflow tract (HP:0011103)2.43612902
72Subaortic stenosis (HP:0001682)2.43612902
73Rimmed vacuoles (HP:0003805)2.40591565
74Mildly elevated creatine phosphokinase (HP:0008180)2.37907432
75Abnormality of the vocal cords (HP:0008777)2.32440186
76Nonprogressive disorder (HP:0003680)2.32400595
77Distal lower limb amyotrophy (HP:0008944)2.30640213
78Myokymia (HP:0002411)2.30308528
79Sudden death (HP:0001699)2.23782705
80Hyperkalemia (HP:0002153)2.22133796
81Hyperinsulinemic hypoglycemia (HP:0000825)2.21237883
82Adducted thumb (HP:0001181)2.19430977
83Neck muscle weakness (HP:0000467)2.18966482
84Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18767449
85Easy fatigability (HP:0003388)2.10236005
86Lipoatrophy (HP:0100578)2.09571276
87Pancreatic islet-cell hyperplasia (HP:0004510)2.02953925
88Abnormality of the calcaneus (HP:0008364)2.02933974
89Respiratory insufficiency due to muscle weakness (HP:0002747)2.01933421
90Muscular dystrophy (HP:0003560)2.01665846
91Dilated cardiomyopathy (HP:0001644)2.00723271
92Hypoglycemic coma (HP:0001325)1.98221941
93Heart block (HP:0012722)1.97245609
94Scapular winging (HP:0003691)1.96535485
95Atonic seizures (HP:0010819)1.93952635
96Reduced subcutaneous adipose tissue (HP:0003758)1.93618974
97Slender build (HP:0001533)1.92898578
98Lower limb amyotrophy (HP:0007210)1.92867475
99Supranuclear gaze palsy (HP:0000605)1.91704760
100Proximal amyotrophy (HP:0007126)1.90842556
101Distal sensory impairment (HP:0002936)1.90454987
102Insulin-resistant diabetes mellitus (HP:0000831)1.90216149
103Paralysis (HP:0003470)1.89620896
104Decreased motor nerve conduction velocity (HP:0003431)1.88198828
105Waddling gait (HP:0002515)1.85084762
106Postural tremor (HP:0002174)1.85025028
107Achilles tendon contracture (HP:0001771)1.80909346
108Ventricular fibrillation (HP:0001663)1.80843489
109Abnormal atrioventricular conduction (HP:0005150)1.80610556
110Neoplasm of the peripheral nervous system (HP:0100007)1.79137232
111Abnormal autonomic nervous system physiology (HP:0012332)1.78415857
112Spinal rigidity (HP:0003306)1.77961350
113Acute necrotizing encephalopathy (HP:0006965)1.75503988
114Exercise intolerance (HP:0003546)1.74376217
115Urinary bladder sphincter dysfunction (HP:0002839)1.74105540
116Oligomenorrhea (HP:0000876)1.73969872
117Abnormality of the neuromuscular junction (HP:0003398)1.73113645
118Fatigable weakness (HP:0003473)1.73113645
119Rapidly progressive (HP:0003678)1.71451895
120Bundle branch block (HP:0011710)1.71447096
121Lower limb muscle weakness (HP:0007340)1.69120416
122Focal seizures (HP:0007359)1.68711530
123Ulnar deviation of finger (HP:0009465)1.68225086
124Hypercortisolism (HP:0001578)1.66012760
125Cholelithiasis (HP:0001081)1.65201171
126Visual hallucinations (HP:0002367)1.65114752
127Enlarged penis (HP:0000040)1.64899247
128Increased CSF protein (HP:0002922)1.64885753
129Failure to thrive in infancy (HP:0001531)1.64556100
130Focal motor seizures (HP:0011153)1.64391833
131Abnormality of the Achilles tendon (HP:0005109)1.64329807
132Palpitations (HP:0001962)1.63336939
133Stridor (HP:0010307)1.63062372
134Ketoacidosis (HP:0001993)1.62960511
135Limb-girdle muscle weakness (HP:0003325)1.62761074
136Symphalangism affecting the phalanges of the hand (HP:0009773)1.62723375
137Limited hip movement (HP:0008800)1.61849650
138Short middle phalanx of the 5th finger (HP:0004220)1.61706387
139Limb-girdle muscle atrophy (HP:0003797)1.61328598
140Abnormal mitochondria in muscle tissue (HP:0008316)1.59616904
141Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.56482860
142Abnormality of the shoulder girdle musculature (HP:0001435)1.55853493
143Acute encephalopathy (HP:0006846)1.54734421
144Progressive macrocephaly (HP:0004481)1.52482852
145Long clavicles (HP:0000890)1.51976626
146Aplasia of the musculature (HP:0100854)1.51785699
147Wrist flexion contracture (HP:0001239)1.51683737
148Hypoglycemic seizures (HP:0002173)1.50527311
149Increased intramyocellular lipid droplets (HP:0012240)1.49235804
150Metatarsus adductus (HP:0001840)1.48248700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.93619205
2PHKG15.20191078
3PHKG25.20191078
4OBSCN4.13753468
5KSR23.91414118
6TTN3.45924638
7NTRK13.18606183
8LMTK23.10035274
9MAP3K22.86957267
10MAP3K92.80004948
11LIMK12.66187608
12NME12.57479011
13AKT32.34689109
14RIPK42.19912119
15MAP2K42.05686638
16PINK12.01658598
17NEK12.01187039
18RET1.98686350
19MINK11.89237291
20NTRK31.84061109
21MATK1.79821767
22MAP2K31.72799756
23LATS21.72426344
24PIK3CG1.49887813
25MAP3K11.44293351
26GRK51.35998126
27MAP2K61.30555011
28PDK41.29125214
29PDK31.29125214
30ARAF1.26543993
31MOS1.24439892
32MARK11.21910184
33MAP3K71.21676656
34PAK61.21658961
35TIE11.21585537
36TRIB31.19355498
37MAP3K121.16577874
38MARK31.15601052
39MAP2K11.13982520
40MAP4K21.12746925
41MAP2K21.11922772
42MAPKAPK31.06755693
43PIK3CA1.06111444
44NEK91.01322813
45EPHA30.98777077
46BMPR1B0.96123431
47RPS6KA20.92419294
48MAPK120.89800707
49WNK10.89228889
50AKT20.85844681
51MAP3K40.84002270
52EPHB10.79763723
53ERBB30.77497069
54BRAF0.75829260
55IRAK30.74244792
56ADRBK20.69488752
57CCNB10.68364866
58FER0.66984588
59PKN10.66983452
60CAMK2D0.63655780
61TLK10.63151671
62SCYL20.62605978
63PRKAA10.62424774
64PRKD30.62100726
65DYRK1B0.61315867
66SGK2230.60284563
67SGK4940.60284563
68MAP3K110.59947411
69PDK20.59903108
70PDK10.59681520
71STK390.56848679
72PLK20.56837456
73PRKG20.56696682
74TRPM70.54957059
75FGFR30.51997739
76CAMK10.51912054
77PDPK10.51467412
78STK110.50431640
79PRKG10.50081399
80CAMK2B0.48295061
81PKN20.47810358
82CDK50.47078936
83BCKDK0.46790334
84DAPK20.43754538
85ABL20.43707991
86STK240.42872596
87CAMK2G0.42276149
88MAPK70.42214155
89OXSR10.41535963
90DMPK0.41465197
91WNK30.40951096
92EPHB20.38974320
93PTK2B0.38949677
94MAPK130.38650046
95ROCK10.38519644
96SGK30.37908746
97WNK40.37311590
98CAMK40.35800504
99JAK20.35142046
100MAP2K70.35076153
101LRRK20.34581713
102ADRBK10.34272042
103PRKAA20.33793336
104PRKACB0.33171242
105CDK140.33065651
106RIPK10.31947927
107GRK10.31534892
108PRKACA0.30470355
109SGK20.29629072
110PTK20.28365436
111FRK0.28285904
112MAPK100.27781967
113CAMKK10.26420165
114PRKCG0.25945118
115RPS6KA50.25415176
116TGFBR10.25109663
117CDC42BPA0.24802549
118MAPK40.24464812
119FLT30.24272925
120DYRK1A0.23863799
121RAF10.23698707
122STK160.22238213
123STK380.21606291
124RPS6KA30.20884762
125TAOK10.20662894
126ACVR1B0.20347052
127SGK10.20297998
128MUSK0.19849474
129PRKCZ0.19433152
130ROCK20.18980797
131ILK0.18312368
132KSR10.17838423
133FGFR40.17764533
134PRKACG0.17600233
135CDK190.17582656
136MAPK110.17019366
137DYRK30.16892736
138CSNK1D0.16287287
139PAK30.15431298
140CAMK2A0.15280794
141EIF2AK30.15015844
142UHMK10.14956415
143CAMKK20.14771119
144CSNK1G20.12280629
145CSNK1A10.12170439
146PRKCA0.11897721
147LATS10.08403551
148PRKCQ0.07867201
149NUAK10.07844849
150DYRK20.07392703
151RPS6KB10.06477638
152RPS6KA60.06423342

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.70129213
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41928381
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.37422387
4Cardiac muscle contraction_Homo sapiens_hsa042602.34713365
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.25721681
6Arginine and proline metabolism_Homo sapiens_hsa003302.21330502
7Insulin signaling pathway_Homo sapiens_hsa049102.07284234
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.05393015
9Thyroid cancer_Homo sapiens_hsa052162.01581363
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00089188
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97301711
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.84063913
13Nitrogen metabolism_Homo sapiens_hsa009101.82279214
14Synaptic vesicle cycle_Homo sapiens_hsa047211.81952905
15Dorso-ventral axis formation_Homo sapiens_hsa043201.81533631
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79003027
17Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.75755114
18Oxytocin signaling pathway_Homo sapiens_hsa049211.73172827
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69132076
20Huntingtons disease_Homo sapiens_hsa050161.66525685
21Butanoate metabolism_Homo sapiens_hsa006501.61607009
22Starch and sucrose metabolism_Homo sapiens_hsa005001.58789486
23Glucagon signaling pathway_Homo sapiens_hsa049221.58100157
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.56523080
25Insulin secretion_Homo sapiens_hsa049111.56058600
26GnRH signaling pathway_Homo sapiens_hsa049121.56037263
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55608567
28Dilated cardiomyopathy_Homo sapiens_hsa054141.49880084
29Calcium signaling pathway_Homo sapiens_hsa040201.42042973
30Arginine biosynthesis_Homo sapiens_hsa002201.40515656
31VEGF signaling pathway_Homo sapiens_hsa043701.38557159
32Gastric acid secretion_Homo sapiens_hsa049711.34365923
33Insulin resistance_Homo sapiens_hsa049311.33789380
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32870994
35Long-term potentiation_Homo sapiens_hsa047201.30769802
36Olfactory transduction_Homo sapiens_hsa047401.28311063
37mTOR signaling pathway_Homo sapiens_hsa041501.27356196
38Fatty acid degradation_Homo sapiens_hsa000711.26905984
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25470707
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23126784
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.20680093
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20235017
43Cholinergic synapse_Homo sapiens_hsa047251.18861268
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17661865
45Glioma_Homo sapiens_hsa052141.16028656
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.14653839
47Circadian rhythm_Homo sapiens_hsa047101.11717436
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09091126
49Dopaminergic synapse_Homo sapiens_hsa047281.08859355
50Phototransduction_Homo sapiens_hsa047441.07806835
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06907359
52Long-term depression_Homo sapiens_hsa047301.04298029
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02686770
54Type II diabetes mellitus_Homo sapiens_hsa049301.02028352
55Circadian entrainment_Homo sapiens_hsa047130.98842808
56Alzheimers disease_Homo sapiens_hsa050100.97446816
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95873130
58AMPK signaling pathway_Homo sapiens_hsa041520.95803715
59Salmonella infection_Homo sapiens_hsa051320.93988119
60Parkinsons disease_Homo sapiens_hsa050120.92651266
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.92064736
62Salivary secretion_Homo sapiens_hsa049700.92034135
63beta-Alanine metabolism_Homo sapiens_hsa004100.90990149
64Tryptophan metabolism_Homo sapiens_hsa003800.89879758
65Sulfur relay system_Homo sapiens_hsa041220.87367097
66Prolactin signaling pathway_Homo sapiens_hsa049170.87349927
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87143686
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84559081
69Phenylalanine metabolism_Homo sapiens_hsa003600.83974337
70Gap junction_Homo sapiens_hsa045400.83621372
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83553073
72Tight junction_Homo sapiens_hsa045300.82864599
73Renin secretion_Homo sapiens_hsa049240.80813925
74Pyruvate metabolism_Homo sapiens_hsa006200.79976038
75Endometrial cancer_Homo sapiens_hsa052130.79687129
76Taste transduction_Homo sapiens_hsa047420.78597255
77Estrogen signaling pathway_Homo sapiens_hsa049150.77882807
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.77153091
79Peroxisome_Homo sapiens_hsa041460.75279105
80Renin-angiotensin system_Homo sapiens_hsa046140.74552024
81Melanogenesis_Homo sapiens_hsa049160.74001329
82Melanoma_Homo sapiens_hsa052180.72397146
83Fatty acid metabolism_Homo sapiens_hsa012120.72057167
84Regulation of autophagy_Homo sapiens_hsa041400.71007812
85ErbB signaling pathway_Homo sapiens_hsa040120.70964031
86Fatty acid elongation_Homo sapiens_hsa000620.70776991
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70592576
88Carbon metabolism_Homo sapiens_hsa012000.70366081
89MAPK signaling pathway_Homo sapiens_hsa040100.69867251
90Choline metabolism in cancer_Homo sapiens_hsa052310.69479002
91Oxidative phosphorylation_Homo sapiens_hsa001900.69312170
92Glutamatergic synapse_Homo sapiens_hsa047240.69303156
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69080698
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.68067780
95Serotonergic synapse_Homo sapiens_hsa047260.67101076
96Fructose and mannose metabolism_Homo sapiens_hsa000510.66951308
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.66932345
98Viral myocarditis_Homo sapiens_hsa054160.66859578
99Oocyte meiosis_Homo sapiens_hsa041140.65813073
100Propanoate metabolism_Homo sapiens_hsa006400.65691178
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64801413
102Pancreatic secretion_Homo sapiens_hsa049720.64143419
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63447704
104Ribosome_Homo sapiens_hsa030100.60603730
105FoxO signaling pathway_Homo sapiens_hsa040680.59787815
106Tyrosine metabolism_Homo sapiens_hsa003500.58976957
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58620733
108Bile secretion_Homo sapiens_hsa049760.58330631
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57804540
110Galactose metabolism_Homo sapiens_hsa000520.57024232
111Non-small cell lung cancer_Homo sapiens_hsa052230.56521707
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56347110
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56346728
114Mineral absorption_Homo sapiens_hsa049780.55658638
115Ovarian steroidogenesis_Homo sapiens_hsa049130.55479787
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54643804
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53109318
118Platelet activation_Homo sapiens_hsa046110.52718958
119Linoleic acid metabolism_Homo sapiens_hsa005910.52638628
120GABAergic synapse_Homo sapiens_hsa047270.51614328
121Thyroid hormone synthesis_Homo sapiens_hsa049180.51331449
122Glycerolipid metabolism_Homo sapiens_hsa005610.51235850
123Endocytosis_Homo sapiens_hsa041440.50994018
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50423464
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49562399
126One carbon pool by folate_Homo sapiens_hsa006700.49223026
127Amoebiasis_Homo sapiens_hsa051460.47959637
128HIF-1 signaling pathway_Homo sapiens_hsa040660.47363557
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46140831
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45335457
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44770784
132Focal adhesion_Homo sapiens_hsa045100.43774207
133Pentose phosphate pathway_Homo sapiens_hsa000300.43432955
134Rap1 signaling pathway_Homo sapiens_hsa040150.42809973
135Histidine metabolism_Homo sapiens_hsa003400.42656118
136Proteasome_Homo sapiens_hsa030500.39420836
137Metabolic pathways_Homo sapiens_hsa011000.39086697
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33076037
139Amphetamine addiction_Homo sapiens_hsa050310.29001202
140PPAR signaling pathway_Homo sapiens_hsa033200.27591953
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26764271
142RNA polymerase_Homo sapiens_hsa030200.25622278
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24865346
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24596801
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24113898
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.23303458

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