TMEM234

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.56762008
2ribosomal small subunit assembly (GO:0000028)6.60081502
3cilium or flagellum-dependent cell motility (GO:0001539)6.48775127
4viral transcription (GO:0019083)5.82567439
5translational termination (GO:0006415)5.50279828
6cilium movement (GO:0003341)5.49420141
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.43604151
8cotranslational protein targeting to membrane (GO:0006613)5.38714712
9protein targeting to ER (GO:0045047)5.34046169
10motile cilium assembly (GO:0044458)5.29988052
11ribosomal small subunit biogenesis (GO:0042274)5.13040201
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.06085633
13protein localization to endoplasmic reticulum (GO:0070972)5.04559320
14epithelial cilium movement (GO:0003351)5.04057114
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84394556
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66095939
17translational elongation (GO:0006414)4.64469561
18DNA deamination (GO:0045006)4.51514921
19positive regulation of tolerance induction (GO:0002645)4.47757430
20viral life cycle (GO:0019058)4.44141289
21cellular protein complex disassembly (GO:0043624)4.23955696
22left/right pattern formation (GO:0060972)4.09694196
23regulation of regulatory T cell differentiation (GO:0045589)4.05181166
24ribosomal large subunit biogenesis (GO:0042273)4.01626458
25regulation of tolerance induction (GO:0002643)3.97330912
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92594783
27signal peptide processing (GO:0006465)3.80760245
28macrophage activation involved in immune response (GO:0002281)3.77647520
29translational initiation (GO:0006413)3.77187541
30translation (GO:0006412)3.73847939
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.70507547
32neutrophil activation (GO:0042119)3.68554647
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67988513
34maturation of SSU-rRNA (GO:0030490)3.67408664
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57660635
36protein complex disassembly (GO:0043241)3.55483738
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50858631
38ATP synthesis coupled proton transport (GO:0015986)3.50858631
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50136493
40axoneme assembly (GO:0035082)3.49943680
41GTP biosynthetic process (GO:0006183)3.49311234
42GPI anchor biosynthetic process (GO:0006506)3.49251118
43detection of other organism (GO:0098543)3.48977030
44detection of bacterium (GO:0016045)3.45143148
45granulocyte activation (GO:0036230)3.44561288
46respiratory chain complex IV assembly (GO:0008535)3.44189008
47protein targeting to membrane (GO:0006612)3.43492279
48T-helper 1 type immune response (GO:0042088)3.40533141
49macromolecular complex disassembly (GO:0032984)3.40448073
50negative regulation of interleukin-12 production (GO:0032695)3.35776592
51proteasome assembly (GO:0043248)3.33344194
52cytochrome complex assembly (GO:0017004)3.31331840
53negative regulation of interleukin-8 production (GO:0032717)3.27688647
54positive regulation by symbiont of host defense response (GO:0052509)3.21028075
55modulation by symbiont of host defense response (GO:0052031)3.21028075
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21028075
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21028075
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.21028075
59modulation by symbiont of host immune response (GO:0052553)3.21028075
60regulation of protein glycosylation (GO:0060049)3.20295784
61regulation of T cell tolerance induction (GO:0002664)3.18663910
62respiratory electron transport chain (GO:0022904)3.18506001
63activated T cell proliferation (GO:0050798)3.16239829
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.15919115
65termination of RNA polymerase III transcription (GO:0006386)3.15919115
66purine nucleotide salvage (GO:0032261)3.14160729
67electron transport chain (GO:0022900)3.13529691
68pyrimidine-containing compound transmembrane transport (GO:0072531)3.11517074
69response to peptidoglycan (GO:0032494)3.09509228
70leukocyte migration involved in inflammatory response (GO:0002523)3.08656558
71protein complex biogenesis (GO:0070271)3.07311577
72CTP biosynthetic process (GO:0006241)3.06898375
73CTP metabolic process (GO:0046036)3.06898375
74positive regulation of mast cell activation (GO:0033005)3.04180867
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.01994682
76neutrophil chemotaxis (GO:0030593)2.99746388
77regulation of cilium movement (GO:0003352)2.98382735
78viral protein processing (GO:0019082)2.96165711
79preassembly of GPI anchor in ER membrane (GO:0016254)2.95342144
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94313009
81detection of external biotic stimulus (GO:0098581)2.94254294
82UTP biosynthetic process (GO:0006228)2.92717086
83detection of molecule of bacterial origin (GO:0032490)2.92266722
84GDP-mannose metabolic process (GO:0019673)2.92079817
85neutrophil migration (GO:1990266)2.91956681
86modulation by symbiont of host cellular process (GO:0044068)2.91531365
87macrophage activation (GO:0042116)2.89750150
88modulation by virus of host process (GO:0019054)2.89711720
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.88028925
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87564359
91mannosylation (GO:0097502)2.87369205
92negative regulation of tumor necrosis factor production (GO:0032720)2.87052263
93neutrophil activation involved in immune response (GO:0002283)2.86684228
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86009065
95guanosine-containing compound biosynthetic process (GO:1901070)2.85166204
96iron-sulfur cluster assembly (GO:0016226)2.83184524
97metallo-sulfur cluster assembly (GO:0031163)2.83184524
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.83152842
99mitochondrial respiratory chain complex assembly (GO:0033108)2.82024817
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81031124
101response to magnesium ion (GO:0032026)2.80874745
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80526815
103negative regulation of toll-like receptor signaling pathway (GO:0034122)2.80496075
104positive regulation of mast cell activation involved in immune response (GO:0033008)2.79287199
105positive regulation of mast cell degranulation (GO:0043306)2.79287199
106mRNA catabolic process (GO:0006402)2.78624801
107GPI anchor metabolic process (GO:0006505)2.78083781
108negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.78081949
109ncRNA 3-end processing (GO:0043628)2.77357391
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76305214
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.76305214
112NADH dehydrogenase complex assembly (GO:0010257)2.76305214
113pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76100385
114phosphatidylglycerol biosynthetic process (GO:0006655)2.72882268
115sequestering of actin monomers (GO:0042989)2.72647826
116cellular response to type I interferon (GO:0071357)2.71852349
117type I interferon signaling pathway (GO:0060337)2.71852349
118tolerance induction (GO:0002507)2.71438497
119branching involved in labyrinthine layer morphogenesis (GO:0060670)2.70757516
120response to type I interferon (GO:0034340)2.70002932
121granulocyte chemotaxis (GO:0071621)2.69974819
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69198300
123pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.68223524
124mannose metabolic process (GO:0006013)2.66264273
125peptidyl-histidine modification (GO:0018202)2.66182198
126ubiquinone biosynthetic process (GO:0006744)2.64383795
127superoxide anion generation (GO:0042554)2.61857591
128response to interferon-beta (GO:0035456)2.61585834
129regulation of interleukin-6 biosynthetic process (GO:0045408)2.60974654
130immunoglobulin mediated immune response (GO:0016064)2.60500826
131UTP metabolic process (GO:0046051)2.60416435
132regulation of cholesterol storage (GO:0010885)2.60104266
133detection of biotic stimulus (GO:0009595)2.59647108
134negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.58253036
135regulation of mitochondrial translation (GO:0070129)2.58054548
136granulocyte migration (GO:0097530)2.57805177
137response to xenobiotic stimulus (GO:0009410)2.56087360
138negative regulation of B cell mediated immunity (GO:0002713)2.55877351
139negative regulation of immunoglobulin mediated immune response (GO:0002890)2.55877351
140regulation of germinal center formation (GO:0002634)2.55730217
141nucleoside diphosphate catabolic process (GO:0009134)2.53148083
142cellular response to interferon-beta (GO:0035458)2.52248320
143RNA catabolic process (GO:0006401)2.52215914
144response to manganese ion (GO:0010042)2.51830950
145regulation of superoxide anion generation (GO:0032928)2.51320454
146regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.47905946
147establishment of protein localization to membrane (GO:0090150)2.47271982
148positive regulation of gamma-delta T cell activation (GO:0046645)2.47141729
149adaptation of signaling pathway (GO:0023058)2.46951843
150intraciliary transport (GO:0042073)2.46517974
151pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.45528883
152mitochondrion degradation (GO:0000422)2.45381955
153deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.45321079
154negative regulation of interleukin-6 production (GO:0032715)2.45264709
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44423262
156amyloid precursor protein catabolic process (GO:0042987)2.44394358
157regulation of metalloenzyme activity (GO:0048552)2.44247130
158hydrogen peroxide biosynthetic process (GO:0050665)2.44192414
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43363227
160regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.42734467
161C-terminal protein lipidation (GO:0006501)2.42284251
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42018336
163myeloid cell activation involved in immune response (GO:0002275)2.40661477
164antigen processing and presentation of endogenous antigen (GO:0019883)2.39892297
165ribonucleoprotein complex biogenesis (GO:0022613)2.38522012
166microglial cell activation (GO:0001774)2.38133788
167pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.38064093
168purine deoxyribonucleotide catabolic process (GO:0009155)2.36936587
169regulation of mast cell degranulation (GO:0043304)2.36877345
170G-protein coupled receptor internalization (GO:0002031)2.36748061
171positive regulation of T cell mediated cytotoxicity (GO:0001916)2.35797224
172telomere maintenance via semi-conservative replication (GO:0032201)2.35651839
173deoxyribonucleotide catabolic process (GO:0009264)2.35119257
174dendritic cell chemotaxis (GO:0002407)2.34959532
175platelet dense granule organization (GO:0060155)2.34903569
176positive regulation of antigen processing and presentation (GO:0002579)2.34010734
177polyamine metabolic process (GO:0006595)2.33939110
178diol metabolic process (GO:0034311)2.33058910
179DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32843404
180regulation of antigen processing and presentation (GO:0002577)2.32364743
181cellular component biogenesis (GO:0044085)2.31929763
182heme biosynthetic process (GO:0006783)2.31814654
183regulation of vitamin D biosynthetic process (GO:0060556)2.31634628
184NIK/NF-kappaB signaling (GO:0038061)2.31570164
185regulation of respiratory burst (GO:0060263)2.31176306
186diacylglycerol metabolic process (GO:0046339)2.31140512
187protein targeting (GO:0006605)2.31013950
188hypotonic response (GO:0006971)2.30968961
189negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.30648453
190signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.29876713
191signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.29876713
192signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.29876713
1937-methylguanosine mRNA capping (GO:0006370)2.29860630
194leukocyte aggregation (GO:0070486)2.29598885
195protein insertion into membrane (GO:0051205)2.29310260
196intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.28656756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.96156026
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.76847741
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.79624264
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.69878132
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66585607
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.55861794
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.30591833
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30364728
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29040795
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.19556229
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.97172507
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.93968724
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91560947
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.80476308
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.78780863
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73477764
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64947058
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58890352
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58163448
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.57710918
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56208906
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50530239
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.47884704
24VDR_23849224_ChIP-Seq_CD4+_Human2.39295625
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.31903816
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.29698309
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28569296
28LXR_22292898_ChIP-Seq_THP-1_Human2.25085458
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23024974
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23001695
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.21758222
32E2F7_22180533_ChIP-Seq_HELA_Human2.20829240
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.19834599
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09802373
35STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09010187
36ELF1_20517297_ChIP-Seq_JURKAT_Human2.06370962
37CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03284887
38DCP1A_22483619_ChIP-Seq_HELA_Human2.01521269
39BCL6_27268052_Chip-Seq_Bcells_Human1.98845806
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.98637741
41BCOR_27268052_Chip-Seq_Bcells_Human1.97461311
42FOXP3_21729870_ChIP-Seq_TREG_Human1.95151504
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.94146723
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93867867
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93104526
46* SPI1_23547873_ChIP-Seq_NB4_Human1.88020670
47ELK1_19687146_ChIP-ChIP_HELA_Human1.86421574
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84338218
49XRN2_22483619_ChIP-Seq_HELA_Human1.82699751
50P68_20966046_ChIP-Seq_HELA_Human1.79692219
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79395599
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75395703
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75280246
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74817162
55TP53_22127205_ChIP-Seq_IMR90_Human1.73923202
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71887069
57SPI1_23127762_ChIP-Seq_K562_Human1.67828161
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66943911
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66657814
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66561094
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65404580
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.62842773
63SMC4_20622854_ChIP-Seq_HELA_Human1.62521458
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.59617165
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59177224
66TTF2_22483619_ChIP-Seq_HELA_Human1.58265200
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57734658
68RACK7_27058665_Chip-Seq_MCF-7_Human1.57228025
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.55018190
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52540655
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.52213354
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51154700
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.48353437
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47390214
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47388475
76CTCF_20526341_ChIP-Seq_ESCs_Human1.43357249
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42802075
78P300_27268052_Chip-Seq_Bcells_Human1.41164665
79PHF8_20622854_ChIP-Seq_HELA_Human1.40866230
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40762816
81GABP_19822575_ChIP-Seq_HepG2_Human1.39601145
82CIITA_25753668_ChIP-Seq_RAJI_Human1.38828956
83SA1_27219007_Chip-Seq_Bcells_Human1.38203830
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37811738
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37066538
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.36028560
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.34835182
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.30440367
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30379337
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29728145
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29284961
92TP63_22573176_ChIP-Seq_HFKS_Human1.27583106
93SCL_19346495_ChIP-Seq_HPC-7_Human1.26082967
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.23358447
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23322177
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22687663
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.21688173
98MYB_26560356_Chip-Seq_TH2_Human1.21131550
99MAF_26560356_Chip-Seq_TH1_Human1.20596776
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20596632
101MYC_18940864_ChIP-ChIP_HL60_Human1.19288789
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18902895
103UTX_26944678_Chip-Seq_JUKART_Human1.18297683
104NCOR1_26117541_ChIP-Seq_K562_Human1.18291597
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18103073
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17628116
107P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17488431
108VDR_21846776_ChIP-Seq_THP-1_Human1.17482139
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17470369
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16921045
111VDR_24763502_ChIP-Seq_THP-1_Human1.15760785
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15752683
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15732319
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15696952
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.14655255
116IRF8_27001747_Chip-Seq_BMDM_Mouse1.14288515
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13657079
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13367852
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13279378
120RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13009512
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12179162
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10035740
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08529968
124KDM2B_26808549_Chip-Seq_DND41_Human1.08309532
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07850720
126MAF_26560356_Chip-Seq_TH2_Human1.07366132
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07137146
128SPI1_20517297_ChIP-Seq_HL60_Human1.06971900
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06867738
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.06401992
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06200846
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05953910
133GATA1_19941826_ChIP-Seq_K562_Human1.04708767
134SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04403013
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03867257
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01825972
137E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01748813
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00409547
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00304817
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99701764
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98793282
142CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97954869
143CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96886840
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96595786
145STAT1_20625510_ChIP-Seq_HELA_Human0.96315748
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95253615
147E2F1_20622854_ChIP-Seq_HELA_Human0.95203867
148CTCF_27219007_Chip-Seq_Bcells_Human0.94661270
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94657686
150EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94645361
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94366583
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94175333
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94149863
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93508625
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93211211
156SOX2_21211035_ChIP-Seq_LN229_Human0.93196302
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92763006
158STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92539117
159SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92489605
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91487094
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90973777
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90425803
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89916187
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89428644
165GATA1_22025678_ChIP-Seq_K562_Human0.88899074
166FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88686853
167CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88221214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy3.49126086
2MP0001835_abnormal_antigen_presentation3.42593623
3MP0009379_abnormal_foot_pigmentation3.38765733
4MP0005671_abnormal_response_to3.05695310
5MP0002148_abnormal_hypersensitivity_rea2.97562003
6MP0009785_altered_susceptibility_to2.89786175
7MP0003303_peritoneal_inflammation2.73218378
8MP0003724_increased_susceptibility_to2.61297716
9MP0003763_abnormal_thymus_physiology2.55861669
10MP0002653_abnormal_ependyma_morphology2.52202842
11MP0003183_abnormal_peptide_metabolism2.36663514
12MP0001873_stomach_inflammation2.35731276
13MP0005025_abnormal_response_to2.34904606
14MP0005000_abnormal_immune_tolerance2.33322730
15MP0009333_abnormal_splenocyte_physiolog2.27912103
16MP0000685_abnormal_immune_system2.26243380
17MP0001790_abnormal_immune_system2.23317525
18MP0005387_immune_system_phenotype2.23317525
19MP0005409_darkened_coat_color2.17323749
20MP0002723_abnormal_immune_serum2.07808689
21MP0001800_abnormal_humoral_immune2.07484274
22MP0002420_abnormal_adaptive_immunity2.05891414
23MP0002452_abnormal_antigen_presenting2.04201625
24MP0001819_abnormal_immune_cell2.03539832
25MP0002419_abnormal_innate_immunity2.00398712
26MP0003693_abnormal_embryo_hatching1.97713011
27MP0003191_abnormal_cellular_cholesterol1.92901442
28MP0003186_abnormal_redox_activity1.90827338
29MP0009278_abnormal_bone_marrow1.85793166
30MP0002132_abnormal_respiratory_system1.83367597
31MP0005075_abnormal_melanosome_morpholog1.82887282
32MP0002396_abnormal_hematopoietic_system1.82774551
33MP0005174_abnormal_tail_pigmentation1.80772517
34MP0002166_altered_tumor_susceptibility1.80550006
35MP0010155_abnormal_intestine_physiology1.76383819
36MP0000490_abnormal_crypts_of1.76159931
37MP0003075_altered_response_to1.75699272
38MP0001986_abnormal_taste_sensitivity1.74543305
39MP0003436_decreased_susceptibility_to1.73529021
40MP0004381_abnormal_hair_follicle1.72128141
41MP0004147_increased_porphyrin_level1.71440178
42MP0005670_abnormal_white_adipose1.71352648
43MP0002405_respiratory_system_inflammati1.69255047
44MP0008004_abnormal_stomach_pH1.68188601
45MP0003866_abnormal_defecation1.66244614
46MP0002398_abnormal_bone_marrow1.61123481
47MP0005310_abnormal_salivary_gland1.59956135
48MP0000716_abnormal_immune_system1.58973622
49MP0005083_abnormal_biliary_tract1.54081004
50MP0000566_synostosis1.52082347
51MP0002006_tumorigenesis1.47561880
52MP0005503_abnormal_tendon_morphology1.45954186
53MP0003172_abnormal_lysosome_physiology1.45079257
54MP0000015_abnormal_ear_pigmentation1.44508961
55MP0000372_irregular_coat_pigmentation1.44337284
56MP0001845_abnormal_inflammatory_respons1.43830603
57MP0001188_hyperpigmentation1.41604189
58MP0002429_abnormal_blood_cell1.38328269
59MP0002722_abnormal_immune_system1.38280980
60MP0002277_abnormal_respiratory_mucosa1.33850418
61MP0006082_CNS_inflammation1.32183921
62MP0000858_altered_metastatic_potential1.31985720
63MP0002095_abnormal_skin_pigmentation1.31287629
64MP0000689_abnormal_spleen_morphology1.30919303
65MP0000613_abnormal_salivary_gland1.30676949
66MP0001663_abnormal_digestive_system1.29186927
67MP0002822_catalepsy1.28954701
68MP0000013_abnormal_adipose_tissue1.28107407
69MP0002933_joint_inflammation1.26405114
70MP0001853_heart_inflammation1.26273158
71MP0005058_abnormal_lysosome_morphology1.25547630
72MP0008875_abnormal_xenobiotic_pharmacok1.24145167
73MP0002163_abnormal_gland_morphology1.23739270
74MP0000703_abnormal_thymus_morphology1.19599801
75MP0003806_abnormal_nucleotide_metabolis1.17083211
76MP0005464_abnormal_platelet_physiology1.16851680
77MP0008469_abnormal_protein_level1.16376693
78MP0000465_gastrointestinal_hemorrhage1.15155603
79MP0004133_heterotaxia1.14719397
80MP0000678_abnormal_parathyroid_gland1.13746691
81MP0003279_aneurysm1.11274035
82MP0002638_abnormal_pupillary_reflex1.11175411
83MP0003656_abnormal_erythrocyte_physiolo1.09870420
84MP0000920_abnormal_myelination1.07961322
85MP0009765_abnormal_xenobiotic_induced1.07271928
86MP0005023_abnormal_wound_healing1.06603752
87MP0003136_yellow_coat_color1.05376620
88MP0006035_abnormal_mitochondrial_morpho1.05344303
89MP0005220_abnormal_exocrine_pancreas1.03878451
90MP0005397_hematopoietic_system_phenotyp1.03711690
91MP0001545_abnormal_hematopoietic_system1.03711690
92MP0008058_abnormal_DNA_repair1.03659634
93MP0005595_abnormal_vascular_smooth1.03273378
94MP0002735_abnormal_chemical_nociception1.02710832
95MP0005636_abnormal_mineral_homeostasis1.01922114
96MP0008789_abnormal_olfactory_epithelium1.01310780
97MP0005379_endocrine/exocrine_gland_phen1.01059833
98MP0009764_decreased_sensitivity_to1.00700485
99MP0001533_abnormal_skeleton_physiology1.00174777
100MP0004947_skin_inflammation0.99606060
101MP0005408_hypopigmentation0.98308284
102MP0000358_abnormal_cell_content/0.98097794
103MP0005381_digestive/alimentary_phenotyp0.97564752
104MP0000750_abnormal_muscle_regeneration0.96780828
105MP0002928_abnormal_bile_duct0.96573242
106MP0009763_increased_sensitivity_to0.91331406
107MP0005197_abnormal_uvea_morphology0.91216706
108MP0002938_white_spotting0.91207268
109MP0005084_abnormal_gallbladder_morpholo0.90772576
110MP0005390_skeleton_phenotype0.87848423
111MP0004510_myositis0.87666627
112MP0004019_abnormal_vitamin_homeostasis0.87550794
113MP0001764_abnormal_homeostasis0.87539257
114MP0000343_altered_response_to0.87252188
115MP0002282_abnormal_trachea_morphology0.86740304
116MP0005451_abnormal_body_composition0.86129800
117MP0005164_abnormal_response_to0.85684050
118MP0001905_abnormal_dopamine_level0.85456257
119MP0001346_abnormal_lacrimal_gland0.85309760
120MP0001851_eye_inflammation0.84403337
121MP0003941_abnormal_skin_development0.83767997
122MP0005166_decreased_susceptibility_to0.83323909
123MP0005165_increased_susceptibility_to0.82744591
124MP0002098_abnormal_vibrissa_morphology0.82116523
125MP0003705_abnormal_hypodermis_morpholog0.81970157
126MP0004043_abnormal_pH_regulation0.81857394
127MP0001529_abnormal_vocalization0.81836775
128MP0001849_ear_inflammation0.81828021
129MP0001542_abnormal_bone_strength0.81250839
130MP0000371_diluted_coat_color0.80164994
131MP0010386_abnormal_urinary_bladder0.79684279
132MP0002138_abnormal_hepatobiliary_system0.79582826
133MP0000470_abnormal_stomach_morphology0.79392474
134MP0008932_abnormal_embryonic_tissue0.78529388
135MP0003878_abnormal_ear_physiology0.78263719
136MP0005377_hearing/vestibular/ear_phenot0.78263719
137MP0006036_abnormal_mitochondrial_physio0.77621804
138MP0002136_abnormal_kidney_physiology0.75818005
139MP0003453_abnormal_keratinocyte_physiol0.75046134
140MP0005501_abnormal_skin_physiology0.74841289
141MP0009384_cardiac_valve_regurgitation0.74107972
142MP0002693_abnormal_pancreas_physiology0.73121389
143MP0003448_altered_tumor_morphology0.72849888
144MP0003300_gastrointestinal_ulcer0.72693081
145MP0000604_amyloidosis0.71802771
146MP0009643_abnormal_urine_homeostasis0.71236700
147MP0000681_abnormal_thyroid_gland0.71219431
148MP0001664_abnormal_digestion0.70182236
149MP0000049_abnormal_middle_ear0.70158148
150MP0005645_abnormal_hypothalamus_physiol0.70055618
151MP0003795_abnormal_bone_structure0.69610345
152MP0008007_abnormal_cellular_replicative0.68198476
153MP0005367_renal/urinary_system_phenotyp0.67231467
154MP0000516_abnormal_urinary_system0.67231467
155MP0002115_abnormal_skeleton_extremities0.65480199
156MP0002249_abnormal_larynx_morphology0.65460831
157MP0003633_abnormal_nervous_system0.65237790

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.01977542
2Abnormal respiratory motile cilium physiology (HP:0012261)6.74330364
3Abnormal respiratory motile cilium morphology (HP:0005938)6.57705237
4Abnormal respiratory epithelium morphology (HP:0012253)6.57705237
5Absent/shortened dynein arms (HP:0200106)6.42355706
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.42355706
7Rhinitis (HP:0012384)6.24595304
8Recurrent gram-negative bacterial infections (HP:0005420)6.10020788
9Abnormal ciliary motility (HP:0012262)6.03785813
10Abnormality of cells of the erythroid lineage (HP:0012130)4.73665878
11Abnormal number of erythroid precursors (HP:0012131)4.52493410
12Reticulocytopenia (HP:0001896)4.48006222
13Chronic bronchitis (HP:0004469)4.42763148
14Nasal polyposis (HP:0100582)4.01941821
15Bronchiectasis (HP:0002110)3.98828024
16Acute necrotizing encephalopathy (HP:0006965)3.89692829
17Mitochondrial inheritance (HP:0001427)3.87249247
18Abnormality of glycolipid metabolism (HP:0010969)3.74980996
19Abnormality of liposaccharide metabolism (HP:0010968)3.74980996
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.74980996
21Hepatocellular necrosis (HP:0001404)3.64847696
22Vacuolated lymphocytes (HP:0001922)3.62927183
23Abnormality of the nasal mucosa (HP:0000433)3.56737685
24Abnormal mitochondria in muscle tissue (HP:0008316)3.41760250
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.38039017
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34058566
27Macrocytic anemia (HP:0001972)3.31111842
28Hepatic necrosis (HP:0002605)3.25367876
29Recurrent abscess formation (HP:0002722)3.23896817
30Renal Fanconi syndrome (HP:0001994)3.20048057
31Chronic sinusitis (HP:0011109)3.19824502
32Pallor (HP:0000980)3.19015588
33Type I transferrin isoform profile (HP:0003642)3.18606289
34Increased hepatocellular lipid droplets (HP:0006565)3.18393030
35Recurrent sinusitis (HP:0011108)3.13648533
36Petechiae (HP:0000967)3.11544973
37Increased CSF lactate (HP:0002490)3.10222440
38Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06929737
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06929737
403-Methylglutaconic aciduria (HP:0003535)3.05572983
41Gingivitis (HP:0000230)3.04773345
42Acute encephalopathy (HP:0006846)3.04204002
43Progressive macrocephaly (HP:0004481)3.02428103
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98268482
45Elevated erythrocyte sedimentation rate (HP:0003565)2.97648474
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93862566
47Recurrent bacterial skin infections (HP:0005406)2.75935586
48Recurrent otitis media (HP:0000403)2.75692768
49Parakeratosis (HP:0001036)2.75082110
50Lipid accumulation in hepatocytes (HP:0006561)2.74976703
51Exertional dyspnea (HP:0002875)2.70914758
52Aplastic anemia (HP:0001915)2.68871379
53IgM deficiency (HP:0002850)2.61092035
54Increased intramyocellular lipid droplets (HP:0012240)2.56583403
55Abnormal glycosylation (HP:0012345)2.54504965
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54504965
57Abnormal protein N-linked glycosylation (HP:0012347)2.54504965
58Abnormal protein glycosylation (HP:0012346)2.54504965
59Congenital ichthyosiform erythroderma (HP:0007431)2.53394163
60Increased serum lactate (HP:0002151)2.50594287
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49353174
62Bronchitis (HP:0012387)2.48843631
63Atelectasis (HP:0100750)2.40887530
64Eczematoid dermatitis (HP:0000976)2.39108174
65Periodontitis (HP:0000704)2.36758508
66Reduced antithrombin III activity (HP:0001976)2.35626655
67Aplasia/hypoplasia of the uterus (HP:0008684)2.34934633
68Thrombocytosis (HP:0001894)2.33843865
69Abnormality of renal resorption (HP:0011038)2.32397588
70Dysostosis multiplex (HP:0000943)2.30230180
71Chronic otitis media (HP:0000389)2.29944595
72Exercise intolerance (HP:0003546)2.29454896
73Microvesicular hepatic steatosis (HP:0001414)2.28942263
74Obstructive lung disease (HP:0006536)2.26310523
75Chronic obstructive pulmonary disease (HP:0006510)2.26310523
76Respiratory failure (HP:0002878)2.21334917
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.20950711
78Increased muscle lipid content (HP:0009058)2.20475510
79Increased cerebral lipofuscin (HP:0011813)2.20283838
80Abnormality of macrophages (HP:0004311)2.20111780
81Purpura (HP:0000979)2.18974745
82Duplicated collecting system (HP:0000081)2.18234697
83Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.17065000
84Severe visual impairment (HP:0001141)2.14650275
85Stridor (HP:0010307)2.13141512
86Hypoplasia of the uterus (HP:0000013)2.13082352
87Infertility (HP:0000789)2.09315531
88Recurrent skin infections (HP:0001581)2.08428785
89Pancytopenia (HP:0001876)2.08145122
90Abnormality of lateral ventricle (HP:0030047)2.06438052
91Cupped ribs (HP:0000887)2.05557176
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.04865978
93True hermaphroditism (HP:0010459)2.04263074
94Optic disc pallor (HP:0000543)2.02514008
95Short femoral neck (HP:0100864)2.01717924
96Systemic lupus erythematosus (HP:0002725)2.01307486
97Leukocytosis (HP:0001974)2.00994530
98Loss of speech (HP:0002371)2.00796536
99Lactic acidosis (HP:0003128)2.00677877
100Amyloidosis (HP:0011034)1.98689164
101Abnormality of the intervertebral disk (HP:0005108)1.98204735
102Pustule (HP:0200039)1.97968079
103Prolonged bleeding time (HP:0003010)1.97781329
104T lymphocytopenia (HP:0005403)1.97642038
105Congenital sensorineural hearing impairment (HP:0008527)1.96294055
106Abnormality of T cell number (HP:0011839)1.95841845
107Interstitial pulmonary disease (HP:0006530)1.95744775
108Occipital encephalocele (HP:0002085)1.95732493
109Autoimmune thrombocytopenia (HP:0001973)1.94706412
110Meningitis (HP:0001287)1.94664109
111Agammaglobulinemia (HP:0004432)1.94375877
112Panhypogammaglobulinemia (HP:0003139)1.94245335
113Patchy hypopigmentation of hair (HP:0011365)1.93543448
114Respiratory difficulties (HP:0002880)1.92211521
115Hypothermia (HP:0002045)1.92073223
116Anencephaly (HP:0002323)1.91696278
117Abnormality of the renal collecting system (HP:0004742)1.90092729
118Male infertility (HP:0003251)1.90081393
119Short nail (HP:0001799)1.90051945
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.87513118
121Asplenia (HP:0001746)1.87471267
122Recurrent viral infections (HP:0004429)1.86641824
123Abnormality of T cells (HP:0002843)1.85865789
124Abnormal hemoglobin (HP:0011902)1.85635005
125Dry hair (HP:0011359)1.85551400
126Recurrent pneumonia (HP:0006532)1.85454234
127Absent hand (HP:0004050)1.85332271
128Single umbilical artery (HP:0001195)1.84431518
129Abnormality of the fetal cardiovascular system (HP:0010948)1.84431518
130Abnormal umbilical cord blood vessels (HP:0011403)1.84431518
131Chronic hepatic failure (HP:0100626)1.84256963
132Poor head control (HP:0002421)1.84149556
133Severe combined immunodeficiency (HP:0004430)1.83460325
134Leukodystrophy (HP:0002415)1.82884268
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.82839569
136Hepatosplenomegaly (HP:0001433)1.82568537
137Myositis (HP:0100614)1.82507760
138IgG deficiency (HP:0004315)1.80406384
139Hypergammaglobulinemia (HP:0010702)1.80036761
140White forelock (HP:0002211)1.79789384
141Hypoproteinemia (HP:0003075)1.79607778
142Abnormality of T cell physiology (HP:0011840)1.79302541
143Neutropenia (HP:0001875)1.78742160
144Recurrent fungal infections (HP:0002841)1.78266360
145Constricted visual fields (HP:0001133)1.77947373
146Abnormal vertebral ossification (HP:0100569)1.77433717
147Abnormality of B cell number (HP:0010975)1.77004815
148B lymphocytopenia (HP:0010976)1.77004815
149Granulocytopenia (HP:0001913)1.76879876
150Oral leukoplakia (HP:0002745)1.76016858
151Urticaria (HP:0001025)1.74566209
152Autoimmune hemolytic anemia (HP:0001890)1.74150248
153Axonal loss (HP:0003447)1.74080337
154Abnormality of magnesium homeostasis (HP:0004921)1.73671412
155Orchitis (HP:0100796)1.72881793
156Increased serum ferritin (HP:0003281)1.72580308
157Nuclear cataract (HP:0100018)1.71380626
158Increased IgE level (HP:0003212)1.71211272
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70509770
160Molar tooth sign on MRI (HP:0002419)1.68654336
161Abnormality of midbrain morphology (HP:0002418)1.68654336
162Tubulointerstitial nephritis (HP:0001970)1.68003335
163Cone-rod dystrophy (HP:0000548)1.66058095
164Spontaneous hematomas (HP:0007420)1.66017091
165Aortic regurgitation (HP:0001659)1.64573627
166Dicarboxylic aciduria (HP:0003215)1.63231199
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63231199
168Metaphyseal cupping (HP:0003021)1.63029535
169Optic neuritis (HP:0100653)1.62744480
170Retrobulbar optic neuritis (HP:0100654)1.62744480
171Aplasia/hypoplasia of the femur (HP:0005613)1.60546733
172Cervical subluxation (HP:0003308)1.60166245
173Microcytic anemia (HP:0001935)1.60074941
174Myocardial infarction (HP:0001658)1.58418692
175Cortical visual impairment (HP:0100704)1.58248830
176Abnormal rod and cone electroretinograms (HP:0008323)1.57288726
177Diaphragmatic weakness (HP:0009113)1.57060157
178Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.56353386
179Gingival bleeding (HP:0000225)1.55429615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.69190622
2STK163.63402360
3MST42.89354706
4TLK12.75720839
5IRAK42.59525371
6ICK2.57232287
7PRKCH2.45613444
8RIPK42.42541320
9IRAK32.39395215
10PIM22.38005620
11TXK2.34399519
12MAP4K12.23892887
13PBK2.22693487
14BLK2.06690692
15TYRO32.05583630
16TEC2.04386105
17CSK2.00207975
18PIK3CG1.96868573
19VRK11.85022704
20DDR21.81946876
21TESK21.81373753
22EIF2AK11.80739024
23EPHB21.73667667
24EPHB11.73556167
25MAP3K141.67188409
26IKBKE1.63246433
27ERN11.61468534
28NME11.60523374
29MAP3K11.59235234
30PRKD21.57524423
31EPHA21.46390195
32CDC42BPA1.44977810
33STK391.44875461
34BTK1.43859337
35MAP3K21.42883647
36TBK11.39561334
37CDK191.39428994
38IKBKB1.37867032
39ZAP701.35181016
40ADRBK21.34942233
41MAP2K21.33905459
42TIE11.33153933
43IRAK11.30098940
44TAOK31.29322363
45MYLK1.27509121
46FGR1.26896362
47MAPKAPK51.26791587
48BMPR1B1.23954461
49EIF2AK31.23425006
50KDR1.22048173
51TYK21.20982189
52BRSK11.17038650
53PTK2B1.16237826
54TAOK11.15637970
55GRK71.14834905
56GRK61.14722868
57SRPK11.10731248
58KIT1.07086288
59CLK11.03517732
60SYK1.02766744
61ADRBK10.99204796
62EIF2AK20.98935266
63EPHA30.98838827
64YES10.98113449
65BCKDK0.97799676
66LYN0.97173219
67MAP3K120.94202279
68ZAK0.93948920
69MATK0.93677752
70BUB10.93281131
71LCK0.92362044
72NLK0.90957350
73TAOK20.89111783
74BCR0.89021006
75JAK30.88872177
76OXSR10.88671235
77RPS6KA50.87004514
78MAPK150.86067283
79MARK20.85460858
80RPS6KA20.85262192
81FES0.85248355
82STK380.84964167
83CDK80.81799447
84ITK0.81171742
85LIMK10.78014344
86PRKCD0.77330777
87MAP2K40.76620699
88TESK10.76255745
89RPS6KA40.74015433
90RPS6KC10.72199253
91RPS6KL10.72199253
92MAP3K60.71519297
93GRK10.71050531
94PIK3CA0.71016135
95DYRK20.69959236
96IRAK20.68361018
97RPS6KA60.66504758
98DYRK1B0.65739975
99MAP2K70.64851693
100MKNK10.62802379
101MAP3K80.62340121
102NEK60.61991686
103KSR10.61557465
104ARAF0.61371428
105PASK0.60550700
106MAP3K50.60308487
107TNK20.59468211
108BMPR20.58540090
109TNIK0.57667401
110ILK0.56677865
111ACVR1B0.55307929
112JAK20.54875468
113STK40.54334251
114TRPM70.53637964
115MAP3K70.53429880
116RPS6KB20.53324248
117BRAF0.53172945
118PIM10.52881206
119CASK0.52515997
120WNK40.52504852
121GSK3A0.52487879
122STK100.52057298
123MAP2K30.50486354
124PRKD10.50224236
125LRRK20.49848511
126KSR20.49644975
127MAPKAPK20.49586461
128NTRK30.49266993
129PRKCQ0.47100867
130INSRR0.47045367
131NEK90.45983284
132AURKB0.45902362
133CDK30.45781205
134WNK10.45048619
135MAP4K20.44925990
136MAP3K110.44836704
137CSNK2A10.44633634
138CSNK1G30.44139029
139SIK10.44081711
140MAPK40.43386443
141DAPK30.42569047
142PKN10.41499238
143ABL10.41318317
144RPS6KA10.41210992
145MAPK70.40746656
146TRIB30.40567218
147HCK0.40440844
148SRC0.39886765
149TGFBR20.38459724
150HIPK20.38281164
151MAP3K30.38032700
152CSF1R0.38006299
153CDK90.37867908
154CAMKK20.37757789
155MKNK20.37505980
156DYRK30.37468358
157FLT30.36982248
158ABL20.35283799
159AURKA0.35053298

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.20031703
2Protein export_Homo sapiens_hsa030603.58551781
3Oxidative phosphorylation_Homo sapiens_hsa001903.19561181
4Proteasome_Homo sapiens_hsa030502.97196549
5Staphylococcus aureus infection_Homo sapiens_hsa051502.78004978
6Parkinsons disease_Homo sapiens_hsa050122.77120348
7RNA polymerase_Homo sapiens_hsa030202.64182397
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35800630
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33747320
10DNA replication_Homo sapiens_hsa030302.21103056
11Viral myocarditis_Homo sapiens_hsa054162.02728373
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02004926
13Alzheimers disease_Homo sapiens_hsa050101.98849444
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95328286
15Primary immunodeficiency_Homo sapiens_hsa053401.95054749
16Huntingtons disease_Homo sapiens_hsa050161.84655997
17Mismatch repair_Homo sapiens_hsa034301.84411788
18Pyrimidine metabolism_Homo sapiens_hsa002401.83390422
19Homologous recombination_Homo sapiens_hsa034401.79736409
20Other glycan degradation_Homo sapiens_hsa005111.73714067
21Collecting duct acid secretion_Homo sapiens_hsa049661.69756026
22Allograft rejection_Homo sapiens_hsa053301.58989400
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56971059
24Base excision repair_Homo sapiens_hsa034101.54128874
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.50695920
26Spliceosome_Homo sapiens_hsa030401.47386507
27Graft-versus-host disease_Homo sapiens_hsa053321.43478660
28Hematopoietic cell lineage_Homo sapiens_hsa046401.39700943
29Nucleotide excision repair_Homo sapiens_hsa034201.38894625
30Sulfur relay system_Homo sapiens_hsa041221.37962198
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33601835
32Non-homologous end-joining_Homo sapiens_hsa034501.32652258
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29248696
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26349691
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25482489
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24231148
37Folate biosynthesis_Homo sapiens_hsa007901.23990597
38TNF signaling pathway_Homo sapiens_hsa046681.22005292
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.20009831
40Autoimmune thyroid disease_Homo sapiens_hsa053201.19944421
41Arachidonic acid metabolism_Homo sapiens_hsa005901.17688531
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17321156
43Sphingolipid metabolism_Homo sapiens_hsa006001.15918904
44Notch signaling pathway_Homo sapiens_hsa043301.13420299
45African trypanosomiasis_Homo sapiens_hsa051431.13346214
46Steroid biosynthesis_Homo sapiens_hsa001001.11910788
47Leishmaniasis_Homo sapiens_hsa051401.11756172
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07051263
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.06962392
50Amoebiasis_Homo sapiens_hsa051461.04512673
51Acute myeloid leukemia_Homo sapiens_hsa052211.00276031
52Fanconi anemia pathway_Homo sapiens_hsa034601.00219878
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00167374
54Measles_Homo sapiens_hsa051620.99768632
55Purine metabolism_Homo sapiens_hsa002300.99115256
56Asthma_Homo sapiens_hsa053100.98281202
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97628672
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96124995
59Rheumatoid arthritis_Homo sapiens_hsa053230.92382434
60Antigen processing and presentation_Homo sapiens_hsa046120.90862758
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90260423
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88889498
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87997605
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.87992372
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87395897
66Sulfur metabolism_Homo sapiens_hsa009200.85884979
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85588480
68Bladder cancer_Homo sapiens_hsa052190.85447112
69Herpes simplex infection_Homo sapiens_hsa051680.85126725
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84697853
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84660353
72Pertussis_Homo sapiens_hsa051330.84486726
73Basal transcription factors_Homo sapiens_hsa030220.84424156
74Chemokine signaling pathway_Homo sapiens_hsa040620.84098008
75Galactose metabolism_Homo sapiens_hsa000520.83350079
76Fatty acid elongation_Homo sapiens_hsa000620.82540386
77RNA degradation_Homo sapiens_hsa030180.80421579
78Malaria_Homo sapiens_hsa051440.80284508
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79419320
80Choline metabolism in cancer_Homo sapiens_hsa052310.75873365
81Complement and coagulation cascades_Homo sapiens_hsa046100.75110813
82Glutathione metabolism_Homo sapiens_hsa004800.74820685
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74044588
84Pancreatic cancer_Homo sapiens_hsa052120.71906216
85Toxoplasmosis_Homo sapiens_hsa051450.71411322
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70153477
87T cell receptor signaling pathway_Homo sapiens_hsa046600.66922281
88Non-small cell lung cancer_Homo sapiens_hsa052230.66324913
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65022107
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64997387
91Legionellosis_Homo sapiens_hsa051340.63485769
92Endocytosis_Homo sapiens_hsa041440.61845536
93Chemical carcinogenesis_Homo sapiens_hsa052040.60722036
94Apoptosis_Homo sapiens_hsa042100.60690851
95Epstein-Barr virus infection_Homo sapiens_hsa051690.60684375
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59257438
97N-Glycan biosynthesis_Homo sapiens_hsa005100.59000858
98Ether lipid metabolism_Homo sapiens_hsa005650.57151524
99Synaptic vesicle cycle_Homo sapiens_hsa047210.56613595
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56324256
101Lysosome_Homo sapiens_hsa041420.54601861
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.54342751
103Linoleic acid metabolism_Homo sapiens_hsa005910.54241970
104Metabolic pathways_Homo sapiens_hsa011000.53284627
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.51721287
106Systemic lupus erythematosus_Homo sapiens_hsa053220.51674628
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51573682
108B cell receptor signaling pathway_Homo sapiens_hsa046620.51383093
109Influenza A_Homo sapiens_hsa051640.50814997
110Hedgehog signaling pathway_Homo sapiens_hsa043400.50519071
111Osteoclast differentiation_Homo sapiens_hsa043800.48324069
112Shigellosis_Homo sapiens_hsa051310.48277025
113Vibrio cholerae infection_Homo sapiens_hsa051100.47590321
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.47534288
115Glycerolipid metabolism_Homo sapiens_hsa005610.47152045
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46026908
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.44973594
118Hepatitis C_Homo sapiens_hsa051600.41141733
119Pancreatic secretion_Homo sapiens_hsa049720.40262565
120Tuberculosis_Homo sapiens_hsa051520.39078655
121Phagosome_Homo sapiens_hsa041450.38908295
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.38718620
123p53 signaling pathway_Homo sapiens_hsa041150.38718114
124Hepatitis B_Homo sapiens_hsa051610.38647039
125Salmonella infection_Homo sapiens_hsa051320.38359251
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37633998
127Renal cell carcinoma_Homo sapiens_hsa052110.35684648
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34473897
129One carbon pool by folate_Homo sapiens_hsa006700.34363753
130Cardiac muscle contraction_Homo sapiens_hsa042600.33637597
131Type I diabetes mellitus_Homo sapiens_hsa049400.33609049
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31783845
133Peroxisome_Homo sapiens_hsa041460.31696520
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31614637
135Regulation of autophagy_Homo sapiens_hsa041400.30949402
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30441663
137RNA transport_Homo sapiens_hsa030130.29357318
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28914187
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28772430
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.28203006
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27931670
142MAPK signaling pathway_Homo sapiens_hsa040100.27011850

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