TMEM235

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.74032278
2acrosome reaction (GO:0007340)8.79981479
3piRNA metabolic process (GO:0034587)7.78991625
4synaptic vesicle docking involved in exocytosis (GO:0016081)7.78489367
5synaptic vesicle maturation (GO:0016188)7.70569312
6positive regulation of action potential (GO:0045760)7.29641440
7glutamate secretion (GO:0014047)7.23566413
8regulation of somitogenesis (GO:0014807)7.06355225
9synaptic vesicle exocytosis (GO:0016079)6.51281862
10regulation of synaptic vesicle exocytosis (GO:2000300)6.07175265
11L-amino acid import (GO:0043092)5.73873546
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.66268126
13intestinal epithelial cell development (GO:0060576)5.51684561
14acrosome assembly (GO:0001675)5.38676391
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38163478
16central nervous system myelination (GO:0022010)5.32010902
17axon ensheathment in central nervous system (GO:0032291)5.32010902
18regulation of synaptic vesicle transport (GO:1902803)5.22909818
19neurotransmitter secretion (GO:0007269)5.18690211
20axonemal dynein complex assembly (GO:0070286)5.09087823
21regulation of neuronal synaptic plasticity (GO:0048168)5.07361621
22male meiosis (GO:0007140)5.03949257
23amino acid import (GO:0043090)5.01107294
24response to methylmercury (GO:0051597)5.01045460
25sperm capacitation (GO:0048240)4.94599150
26regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93514079
27neuronal ion channel clustering (GO:0045161)4.91995744
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.91520217
29sodium ion export (GO:0071436)4.84979608
30locomotory exploration behavior (GO:0035641)4.78100758
31binding of sperm to zona pellucida (GO:0007339)4.69975846
32sperm-egg recognition (GO:0035036)4.64946285
33fusion of sperm to egg plasma membrane (GO:0007342)4.62910507
34sperm motility (GO:0030317)4.59853319
35tachykinin receptor signaling pathway (GO:0007217)4.53957348
36positive regulation of synaptic transmission, GABAergic (GO:0032230)4.52117674
37regulation of meiosis I (GO:0060631)4.50404309
38righting reflex (GO:0060013)4.49325327
39epithelial cilium movement (GO:0003351)4.49306644
40synaptonemal complex organization (GO:0070193)4.46477082
41ionotropic glutamate receptor signaling pathway (GO:0035235)4.45658634
42DNA methylation involved in gamete generation (GO:0043046)4.43481460
43regulation of long-term neuronal synaptic plasticity (GO:0048169)4.42732922
44potassium ion homeostasis (GO:0055075)4.40827610
45neuromuscular process controlling posture (GO:0050884)4.40744305
46heparin metabolic process (GO:0030202)4.37576246
47heparin biosynthetic process (GO:0030210)4.37576246
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35706536
49positive regulation of synapse maturation (GO:0090129)4.34813141
50synaptonemal complex assembly (GO:0007130)4.29215130
51regulation of action potential (GO:0098900)4.28919004
52regulation of acrosome reaction (GO:0060046)4.25884960
53vocalization behavior (GO:0071625)4.24737136
54potassium ion import (GO:0010107)4.23979531
55cell fate commitment involved in formation of primary germ layer (GO:0060795)4.23375325
56neurotransmitter transport (GO:0006836)4.22935482
57neuronal action potential propagation (GO:0019227)4.20459251
58cerebellar granule cell differentiation (GO:0021707)4.16705670
59regulation of cilium movement (GO:0003352)4.16217807
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15719129
61spermatid development (GO:0007286)4.15292785
62cell migration in hindbrain (GO:0021535)4.13750853
63cell-cell recognition (GO:0009988)4.10201335
64exploration behavior (GO:0035640)4.07374737
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.06945454
66multicellular organism reproduction (GO:0032504)4.04516682
67neuron remodeling (GO:0016322)4.01963279
68postsynaptic membrane organization (GO:0001941)4.00019251
69presynaptic membrane organization (GO:0097090)3.99475552
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99029015
71myelin maintenance (GO:0043217)3.98742796
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96810508
73synaptic transmission, glutamatergic (GO:0035249)3.96216805
74positive regulation of dendritic spine development (GO:0060999)3.95600296
75cilium movement (GO:0003341)3.95540510
76positive regulation of protein dephosphorylation (GO:0035307)3.94034163
77regulation of synaptic plasticity (GO:0048167)3.91729100
78motile cilium assembly (GO:0044458)3.91321303
79regulation of glutamate receptor signaling pathway (GO:1900449)3.90076243
80regulation of neurotransmitter levels (GO:0001505)3.86753718
81neurotransmitter uptake (GO:0001504)3.85757843
82positive regulation of digestive system process (GO:0060456)3.81635309
83startle response (GO:0001964)3.81528385
84regulation of neurotransmitter secretion (GO:0046928)3.77313135
85regulation of voltage-gated calcium channel activity (GO:1901385)3.75583430
86neuromuscular process controlling balance (GO:0050885)3.75487363
87negative regulation of dendrite morphogenesis (GO:0050774)3.73628607
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68785871
89acidic amino acid transport (GO:0015800)3.68605926
90ventricular system development (GO:0021591)3.68378894
91heme transport (GO:0015886)3.68218033
92neuron cell-cell adhesion (GO:0007158)3.67485818
93positive regulation of membrane potential (GO:0045838)3.67170552
94regulation of synapse structural plasticity (GO:0051823)3.65956705
95protein localization to synapse (GO:0035418)3.65499604
96calcium ion-dependent exocytosis (GO:0017156)3.63045592
97negative regulation of organelle assembly (GO:1902116)3.62382485
98regulation of glucocorticoid secretion (GO:2000849)3.61996767
99neuron-neuron synaptic transmission (GO:0007270)3.56588582
100glutamate receptor signaling pathway (GO:0007215)3.56341616
101neurotransmitter-gated ion channel clustering (GO:0072578)3.56240300
102cerebellar Purkinje cell differentiation (GO:0021702)3.56119570
103regulation of ARF protein signal transduction (GO:0032012)3.55910542
104male meiosis I (GO:0007141)3.54454387
105regulation of neurotransmitter transport (GO:0051588)3.50897216
106regulation of corticosteroid hormone secretion (GO:2000846)3.50743249
107microtubule severing (GO:0051013)3.50017400
108chromosome organization involved in meiosis (GO:0070192)3.47963098
109substantia nigra development (GO:0021762)3.46307651
110gamma-aminobutyric acid signaling pathway (GO:0007214)3.45677168
111regulation of dendritic spine morphogenesis (GO:0061001)3.45546344
112gamma-aminobutyric acid transport (GO:0015812)3.44133968
113myelination (GO:0042552)3.43992917
114regulation of synapse maturation (GO:0090128)3.43268496
115plasma membrane fusion (GO:0045026)3.42373385
116axon ensheathment (GO:0008366)3.42208727
117ensheathment of neurons (GO:0007272)3.42208727
118negative regulation of heart rate (GO:0010459)3.42156005
119cell communication by electrical coupling (GO:0010644)3.40805853
120synaptic vesicle endocytosis (GO:0048488)3.40624689
121regulation of dendritic spine development (GO:0060998)3.40267705
122SMAD protein complex assembly (GO:0007183)3.39660600
123cellular sodium ion homeostasis (GO:0006883)3.38583745
124regulation of postsynaptic membrane potential (GO:0060078)3.37466921
125astrocyte development (GO:0014002)3.36495685
126long-term synaptic potentiation (GO:0060291)3.35993506
127positive regulation of neurotransmitter secretion (GO:0001956)3.35278549
128cellular potassium ion homeostasis (GO:0030007)3.34607636
129regulation of response to osmotic stress (GO:0047484)3.33236028
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32664767
131L-glutamate transport (GO:0015813)3.31044342
132positive regulation of neurotransmitter transport (GO:0051590)3.30108639
133regulation of phospholipid biosynthetic process (GO:0071071)3.29962423
134transmission of nerve impulse (GO:0019226)3.27292993
135establishment of protein localization to mitochondrial membrane (GO:0090151)3.26080349
136long-term memory (GO:0007616)3.25389551
137dendritic spine morphogenesis (GO:0060997)3.23682261
138presynaptic membrane assembly (GO:0097105)3.21225447
139meiotic nuclear division (GO:0007126)3.18672949
140regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17280244
141regulation of synaptic transmission (GO:0050804)3.16675679
142regulation of vesicle fusion (GO:0031338)3.14347210
143reproduction (GO:0000003)3.14257624
144long-chain fatty acid biosynthetic process (GO:0042759)3.11587986
145positive regulation of dendritic spine morphogenesis (GO:0061003)3.11514235
146mRNA polyadenylation (GO:0006378)3.10725692
147negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09965461
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07241854
149spermatogenesis (GO:0007283)3.06977784
150negative regulation of meiosis (GO:0045835)3.06664591
151regulation of protein dephosphorylation (GO:0035304)3.06015410
152male gamete generation (GO:0048232)3.05787428
153meiosis I (GO:0007127)3.05626503
154neuropeptide signaling pathway (GO:0007218)3.05292387
155peptidyl-tyrosine autophosphorylation (GO:0038083)3.03562068
156membrane depolarization (GO:0051899)3.02302106
157cytoskeletal anchoring at plasma membrane (GO:0007016)3.01386599
158membrane depolarization during action potential (GO:0086010)2.97796660
159synaptic transmission (GO:0007268)2.97710278
160detection of calcium ion (GO:0005513)2.96837678
161labyrinthine layer development (GO:0060711)2.96427765
162microtubule depolymerization (GO:0007019)2.95496025
163positive regulation of dendrite development (GO:1900006)2.94559772
164proline transport (GO:0015824)2.92938414
165phosphorelay signal transduction system (GO:0000160)2.92756711
166positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92555050
167layer formation in cerebral cortex (GO:0021819)2.92298534
168regulation of chromatin binding (GO:0035561)2.89297792
169regulation of microtubule-based movement (GO:0060632)2.88596830
170autophagic vacuole assembly (GO:0000045)2.87544372
171regulation of mRNA 3-end processing (GO:0031440)2.85778530
172lens morphogenesis in camera-type eye (GO:0002089)2.84884794
173positive regulation of mRNA 3-end processing (GO:0031442)2.84506538
174negative regulation of skeletal muscle tissue development (GO:0048642)2.84275690
175gamete generation (GO:0007276)2.81626799
176regulation of transmission of nerve impulse (GO:0051969)2.81404729
177meiotic cell cycle (GO:0051321)2.81036201
178negative regulation of muscle hypertrophy (GO:0014741)2.74951715
179negative regulation of inclusion body assembly (GO:0090084)2.69000288
180negative regulation of meiotic cell cycle (GO:0051447)2.66726052
181iron coordination entity transport (GO:1901678)2.66303178
182bone trabecula formation (GO:0060346)2.66203274
183RNA polyadenylation (GO:0043631)2.63665634
184behavioral defense response (GO:0002209)2.63565803
185behavioral fear response (GO:0001662)2.63565803
186carnitine transmembrane transport (GO:1902603)2.63467503
187negative regulation of BMP signaling pathway (GO:0030514)2.62581467
188fertilization (GO:0009566)2.58006851
189regulation of spindle checkpoint (GO:0090231)2.55536288
190cerebellum development (GO:0021549)2.54578910
191regulation of histone H3-K9 methylation (GO:0051570)2.53345446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.12443028
2STAT6_21828071_ChIP-Seq_BEAS2B_Human6.76439413
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.41476799
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.62132028
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49617318
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.92404069
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77617396
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72341633
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52437043
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51083250
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34352713
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.34299455
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18730919
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09537302
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06865599
16REST_21632747_ChIP-Seq_MESCs_Mouse2.03902961
17AR_21572438_ChIP-Seq_LNCaP_Human1.99434042
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.89513661
19RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.81094308
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.78094496
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75301724
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72348405
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63375024
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59940856
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.57068584
26RING1B_27294783_Chip-Seq_ESCs_Mouse1.54309826
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54029370
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51749353
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50640166
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50640166
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49535824
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.46000209
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.42500846
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42102040
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.41519746
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38415734
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36854153
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.36600912
39STAT1_20625510_ChIP-Seq_HELA_Human1.35031891
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.34824745
41ZNF274_21170338_ChIP-Seq_K562_Hela1.34363391
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34310033
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34027119
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.34017507
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33594341
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30492589
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28825913
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.26851436
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26430992
50KDM2B_26808549_Chip-Seq_K562_Human1.26199443
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26147502
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24923187
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24670520
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21449696
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20135616
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19674291
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19674291
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19674291
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.19465878
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.19346656
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19101404
62GBX2_23144817_ChIP-Seq_PC3_Human1.18672258
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14768897
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13947317
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12196311
66AR_19668381_ChIP-Seq_PC3_Human1.09839175
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09083961
68LXR_22292898_ChIP-Seq_THP-1_Human1.07560085
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07438373
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06439302
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06390657
72OCT4_19829295_ChIP-Seq_ESCs_Human1.04738731
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04445296
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04034164
75DROSHA_22980978_ChIP-Seq_HELA_Human1.03397754
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.01555428
77SOX2_21211035_ChIP-Seq_LN229_Human1.01462903
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99855193
79POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99142531
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98960280
81CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98747219
82SOX2_21211035_ChIP-Seq_LN229_Gbm0.97684536
83KLF4_19829295_ChIP-Seq_ESCs_Human0.97617367
84CTCF_27219007_Chip-Seq_Bcells_Human0.97154140
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96948859
86RNF2_27304074_Chip-Seq_NSC_Mouse0.96755038
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96130080
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95844417
89SALL1_21062744_ChIP-ChIP_HESCs_Human0.95361658
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94979934
91REST_18959480_ChIP-ChIP_MESCs_Mouse0.93973291
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93361775
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93125386
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91165856
95DPY_21335234_ChIP-Seq_ESCs_Mouse0.89993421
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89790442
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89184194
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88422708
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88006198
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86250541
101EGR1_19032775_ChIP-ChIP_M12_Human0.85988055
102SMC4_20622854_ChIP-Seq_HELA_Human0.85019285
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84917867
104TP53_16413492_ChIP-PET_HCT116_Human0.84298674
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83810259
106SMAD4_21799915_ChIP-Seq_A2780_Human0.83750045
107NFYB_21822215_ChIP-Seq_K562_Human0.82773073
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.82722381
109TBL1_22424771_ChIP-Seq_293T_Human0.81886170
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81267013
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80639352
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80637497
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80257942
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80089106
115MYC_19915707_ChIP-ChIP_AK7_Human0.79257111
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78486603
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78268463
118GATA6_21074721_ChIP-Seq_CACO-2_Human0.78066769
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77909348
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.77432050
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77092314
122TP53_22127205_ChIP-Seq_IMR90_Human0.77050531
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.75567741
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75399961
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75152306
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75152306
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74340261
128KDM2B_26808549_Chip-Seq_DND41_Human0.74167810
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74130427
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.73783243
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.73635000
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.73482526
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72571850
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.72524934
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.72512370
136TCF4_23295773_ChIP-Seq_U87_Human0.72424650
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71928023
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.71307468
139KDM2B_26808549_Chip-Seq_REH_Human0.71069806
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71064322
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.70965673
142ER_23166858_ChIP-Seq_MCF-7_Human0.69924310
143NFYA_21822215_ChIP-Seq_K562_Human0.69650846
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69626683
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.69292654
146STAT1_17558387_ChIP-Seq_HELA_Human0.68943990
147PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68923173
148CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68393640
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68242057
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.66949330
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.66364064
152ZFP57_27257070_Chip-Seq_ESCs_Mouse0.66226494
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.65945685
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.65379106
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65199653
156CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64895455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.77323109
2MP0005410_abnormal_fertilization6.04784596
3MP0004270_analgesia4.61313693
4MP0004142_abnormal_muscle_tone4.03899392
5MP0005423_abnormal_somatic_nervous4.02071096
6MP0009046_muscle_twitch3.61701472
7MP0006072_abnormal_retinal_apoptosis3.47840272
8MP0008961_abnormal_basal_metabolism3.14942355
9MP0005360_urolithiasis2.87814230
10MP0002734_abnormal_mechanical_nocicepti2.81379181
11MP0003705_abnormal_hypodermis_morpholog2.73407104
12MP0001968_abnormal_touch/_nociception2.71719785
13MP0003698_abnormal_male_reproductive2.71290198
14MP0001440_abnormal_grooming_behavior2.66246571
15MP0005623_abnormal_meninges_morphology2.55027003
16MP0003329_amyloid_beta_deposits2.54116622
17MP0008877_abnormal_DNA_methylation2.52952649
18MP0004885_abnormal_endolymph2.32164708
19MP0003880_abnormal_central_pattern2.31616170
20MP0004233_abnormal_muscle_weight2.24842449
21MP0001929_abnormal_gametogenesis2.22763315
22MP0002735_abnormal_chemical_nociception2.15897754
23MP0003172_abnormal_lysosome_physiology2.05444912
24MP0009780_abnormal_chondrocyte_physiolo2.05032907
25MP0010352_gastrointestinal_tract_polyps2.04583479
26MP0004859_abnormal_synaptic_plasticity2.03781281
27MP0003879_abnormal_hair_cell2.02748677
28MP0003633_abnormal_nervous_system1.97813450
29MP0000372_irregular_coat_pigmentation1.97341129
30MP0001346_abnormal_lacrimal_gland1.96874328
31MP0002736_abnormal_nociception_after1.95496357
32MP0002733_abnormal_thermal_nociception1.79660709
33MP0000462_abnormal_digestive_system1.78245126
34MP0002210_abnormal_sex_determination1.75964915
35MP0003631_nervous_system_phenotype1.73736582
36MP0008569_lethality_at_weaning1.73416769
37MP0003045_fibrosis1.72166913
38MP0003959_abnormal_lean_body1.66173338
39MP0001486_abnormal_startle_reflex1.65613714
40MP0010386_abnormal_urinary_bladder1.64380956
41MP0003787_abnormal_imprinting1.62807769
42MP0005646_abnormal_pituitary_gland1.61912282
43MP0002064_seizures1.61059370
44MP0001145_abnormal_male_reproductive1.52860326
45MP0005551_abnormal_eye_electrophysiolog1.52441196
46MP0001905_abnormal_dopamine_level1.51166326
47MP0002557_abnormal_social/conspecific_i1.50495469
48MP0003635_abnormal_synaptic_transmissio1.50404173
49MP0001984_abnormal_olfaction1.50393245
50MP0006035_abnormal_mitochondrial_morpho1.46717176
51MP0001177_atelectasis1.44560629
52MP0003646_muscle_fatigue1.44497861
53MP0002161_abnormal_fertility/fecundity1.44458895
54MP0002272_abnormal_nervous_system1.43100674
55MP0002229_neurodegeneration1.41592185
56MP0004742_abnormal_vestibular_system1.36351520
57MP0009384_cardiac_valve_regurgitation1.36328363
58MP0004145_abnormal_muscle_electrophysio1.34479174
59MP0000653_abnormal_sex_gland1.30832310
60MP0005167_abnormal_blood-brain_barrier1.26650970
61MP0002572_abnormal_emotion/affect_behav1.24873142
62MP0000604_amyloidosis1.24396674
63MP0000358_abnormal_cell_content/1.21875547
64MP0003075_altered_response_to1.20270688
65MP0002067_abnormal_sensory_capabilities1.15620139
66MP0000920_abnormal_myelination1.13553959
67MP0001963_abnormal_hearing_physiology1.11755425
68MP0001529_abnormal_vocalization1.10687575
69MP0005253_abnormal_eye_physiology1.10456512
70MP0001485_abnormal_pinna_reflex1.08380524
71MP0003690_abnormal_glial_cell1.07813234
72MP0008770_decreased_survivor_rate1.06001947
73MP0001666_abnormal_nutrient_absorption1.05198093
74MP0003123_paternal_imprinting1.04592532
75MP0006276_abnormal_autonomic_nervous1.04567444
76MP0002653_abnormal_ependyma_morphology1.03222163
77MP0000470_abnormal_stomach_morphology1.02535937
78MP0009745_abnormal_behavioral_response1.02025157
79MP0002822_catalepsy0.99935538
80MP0001299_abnormal_eye_distance/0.98102437
81MP0008874_decreased_physiological_sensi0.98069395
82MP0000778_abnormal_nervous_system0.97218000
83MP0002063_abnormal_learning/memory/cond0.94082139
84MP0010678_abnormal_skin_adnexa0.92913789
85MP0003890_abnormal_embryonic-extraembry0.92018361
86MP0002971_abnormal_brown_adipose0.91825422
87MP0002332_abnormal_exercise_endurance0.90696314
88MP0000955_abnormal_spinal_cord0.90479459
89MP0004147_increased_porphyrin_level0.87988698
90MP0002066_abnormal_motor_capabilities/c0.86540214
91MP0008260_abnormal_autophagy0.86455295
92MP0001502_abnormal_circadian_rhythm0.84999236
93MP0003122_maternal_imprinting0.84726687
94MP0003638_abnormal_response/metabolism_0.83888107
95MP0000762_abnormal_tongue_morphology0.83284129
96MP0001188_hyperpigmentation0.83212258
97MP0005083_abnormal_biliary_tract0.81031889
98MP0001986_abnormal_taste_sensitivity0.80137399
99MP0000003_abnormal_adipose_tissue0.78329966
100MP0005195_abnormal_posterior_eye0.76362611
101MP0005535_abnormal_body_temperature0.75913465
102MP0002796_impaired_skin_barrier0.75820916
103MP0000566_synostosis0.75262367
104MP0000750_abnormal_muscle_regeneration0.73983455
105MP0008057_abnormal_DNA_replication0.72642696
106MP0002882_abnormal_neuron_morphology0.72327002
107MP0002896_abnormal_bone_mineralization0.72175149
108MP0004484_altered_response_of0.70358814
109MP0002114_abnormal_axial_skeleton0.70238017
110MP0002752_abnormal_somatic_nervous0.69934101
111MP0005085_abnormal_gallbladder_physiolo0.69072453
112MP0001970_abnormal_pain_threshold0.68791245
113MP0005391_vision/eye_phenotype0.68415161
114MP0003632_abnormal_nervous_system0.67426915
115MP0001501_abnormal_sleep_pattern0.66603185
116MP0002090_abnormal_vision0.66296159
117MP0002069_abnormal_eating/drinking_beha0.65990311
118MP0005365_abnormal_bile_salt0.65354908
119MP0004811_abnormal_neuron_physiology0.64454988
120MP0003091_abnormal_cell_migration0.64283311
121MP0005266_abnormal_metabolism0.63931896
122MP0000427_abnormal_hair_cycle0.63720323
123MP0000747_muscle_weakness0.63628358
124MP0002269_muscular_atrophy0.63109742
125MP0008872_abnormal_physiological_respon0.62959967
126MP0002751_abnormal_autonomic_nervous0.61958503
127MP0002638_abnormal_pupillary_reflex0.61864295
128MP0002184_abnormal_innervation0.61246971
129MP0002111_abnormal_tail_morphology0.60747319
130MP0000579_abnormal_nail_morphology0.60582060
131MP0002152_abnormal_brain_morphology0.60315299
132MP0004130_abnormal_muscle_cell0.60149489
133MP0004924_abnormal_behavior0.59759756
134MP0005386_behavior/neurological_phenoty0.59759756
135MP0003634_abnormal_glial_cell0.59564608
136MP0005166_decreased_susceptibility_to0.59163185
137MP0005197_abnormal_uvea_morphology0.58626366
138MP0010769_abnormal_survival0.57962847
139MP0005452_abnormal_adipose_tissue0.57869370
140MP0003183_abnormal_peptide_metabolism0.57555942
141MP0010329_abnormal_lipoprotein_level0.57350133
142MP0002970_abnormal_white_adipose0.56808454
143MP0006036_abnormal_mitochondrial_physio0.56738242
144MP0000026_abnormal_inner_ear0.51527204
145MP0002089_abnormal_postnatal_growth/wei0.50323984
146MP0002082_postnatal_lethality0.49774213
147MP0010770_preweaning_lethality0.49774213
148MP0010768_mortality/aging0.49599149
149MP0002909_abnormal_adrenal_gland0.48076147
150MP0004510_myositis0.46626415
151MP0003938_abnormal_ear_development0.46555314
152MP0001943_abnormal_respiration0.46432448
153MP0001348_abnormal_lacrimal_gland0.45869184
154MP0003956_abnormal_body_size0.45721243
155MP0002133_abnormal_respiratory_system0.45301320
156MP0005388_respiratory_system_phenotype0.45301320
157MP0002873_normal_phenotype0.44531045
158MP0003861_abnormal_nervous_system0.42389586
159MP0003137_abnormal_impulse_conducting0.42113679

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.41559246
2Focal motor seizures (HP:0011153)6.74535873
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.27372074
4Focal seizures (HP:0007359)5.76669751
5Action tremor (HP:0002345)5.54154823
6Abnormality of the lower motor neuron (HP:0002366)5.43438309
7Absent/shortened dynein arms (HP:0200106)5.38228594
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.38228594
9Ankle clonus (HP:0011448)5.32893887
10Anomalous pulmonary venous return (HP:0010772)5.32141462
11Diplopia (HP:0000651)5.17435853
12Abnormality of binocular vision (HP:0011514)5.17435853
13Abnormality of the odontoid process (HP:0003310)5.10062505
14Abnormality of the pulmonary veins (HP:0011718)5.03894582
15Neurofibrillary tangles (HP:0002185)4.87475494
16Febrile seizures (HP:0002373)4.82832026
17Buphthalmos (HP:0000557)4.80286765
18Epileptic encephalopathy (HP:0200134)4.80219500
19Atonic seizures (HP:0010819)4.52971080
20Disproportionate short-trunk short stature (HP:0003521)4.51861482
21Cerebral hypomyelination (HP:0006808)4.50971368
22Spastic gait (HP:0002064)4.44179455
23Abnormal respiratory motile cilium physiology (HP:0012261)4.07375131
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.06970293
25Degeneration of the lateral corticospinal tracts (HP:0002314)4.06970293
26Scanning speech (HP:0002168)4.00060580
27Visual hallucinations (HP:0002367)3.97160448
28Abnormality of the corticospinal tract (HP:0002492)3.90920851
29Upper limb muscle weakness (HP:0003484)3.88553340
30Abnormal respiratory motile cilium morphology (HP:0005938)3.86669913
31Abnormal respiratory epithelium morphology (HP:0012253)3.86669913
32Overlapping toe (HP:0001845)3.85572360
33Hemorrhage of the eye (HP:0011885)3.82353214
34Pseudobulbar signs (HP:0002200)3.82031825
35Generalized tonic-clonic seizures (HP:0002069)3.78801923
36Cerebral inclusion bodies (HP:0100314)3.77270338
37Rhinitis (HP:0012384)3.75039217
38Intention tremor (HP:0002080)3.69065402
39Peripheral hypomyelination (HP:0007182)3.60368580
40Pendular nystagmus (HP:0012043)3.57660001
41Abnormal eating behavior (HP:0100738)3.57481115
42Overriding aorta (HP:0002623)3.37451018
43Urinary urgency (HP:0000012)3.34460557
44Absence seizures (HP:0002121)3.28788433
45Urinary bladder sphincter dysfunction (HP:0002839)3.24533200
46Hypoplasia of the odontoid process (HP:0003311)3.24504469
47Progressive external ophthalmoplegia (HP:0000590)3.23933382
48Conjunctival telangiectasia (HP:0000524)3.19044040
49Limb dystonia (HP:0002451)3.18478394
50Dialeptic seizures (HP:0011146)3.14243919
51Papilledema (HP:0001085)3.14108693
52Broad ribs (HP:0000885)3.12195938
53Obstructive sleep apnea (HP:0002870)3.11510737
54Hemiplegia (HP:0002301)3.09037690
55Torticollis (HP:0000473)3.08975988
56Lower limb muscle weakness (HP:0007340)3.08212838
57Hypochromic microcytic anemia (HP:0004840)3.07068121
58Tetraplegia (HP:0002445)3.06998318
59Thoracic kyphosis (HP:0002942)2.99443256
60Truncal ataxia (HP:0002078)2.97048638
61Delusions (HP:0000746)2.95763952
62Congenital glaucoma (HP:0001087)2.95586027
63Chronic bronchitis (HP:0004469)2.92369958
64Annular pancreas (HP:0001734)2.91262507
65Choreoathetosis (HP:0001266)2.88903331
66Increased circulating renin level (HP:0000848)2.87733018
67Insomnia (HP:0100785)2.84456158
68Slow saccadic eye movements (HP:0000514)2.82494562
69Abnormal ciliary motility (HP:0012262)2.81152196
70Impaired vibration sensation in the lower limbs (HP:0002166)2.80752588
71Status epilepticus (HP:0002133)2.76135867
72Sensory axonal neuropathy (HP:0003390)2.70800153
73Depression (HP:0000716)2.70207339
74Nasal polyposis (HP:0100582)2.68936980
75Infertility (HP:0000789)2.67904375
76Neuronal loss in central nervous system (HP:0002529)2.67167596
77Akinesia (HP:0002304)2.66260040
78Abnormality of the labia minora (HP:0012880)2.65642463
79Hemiparesis (HP:0001269)2.64247487
80Vertebral arch anomaly (HP:0008438)2.63889732
81Focal dystonia (HP:0004373)2.60943822
82Anxiety (HP:0000739)2.60082749
83J-shaped sella turcica (HP:0002680)2.60077457
84Apathy (HP:0000741)2.59062020
85Rigidity (HP:0002063)2.58718305
86CNS hypomyelination (HP:0003429)2.56011874
87Bradykinesia (HP:0002067)2.55841998
88Epileptiform EEG discharges (HP:0011182)2.52908716
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.52441817
90Poor eye contact (HP:0000817)2.51323804
91Abnormal vertebral ossification (HP:0100569)2.50048067
92Amyotrophic lateral sclerosis (HP:0007354)2.46460209
93Tubular atrophy (HP:0000092)2.45285458
94Fibular aplasia (HP:0002990)2.45105620
95Abnormality of the periventricular white matter (HP:0002518)2.43544948
96Sleep apnea (HP:0010535)2.39144077
97Elfin facies (HP:0004428)2.38629280
98Hypoplastic ischia (HP:0003175)2.38609915
99Craniofacial dystonia (HP:0012179)2.37821588
100Deformed sella turcica (HP:0002681)2.36893917
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35017576
102Upper motor neuron abnormality (HP:0002127)2.33559957
103Diminished motivation (HP:0000745)2.30857978
104Megalencephaly (HP:0001355)2.30568741
105Myelomeningocele (HP:0002475)2.29313364
106Broad distal phalanx of finger (HP:0009836)2.28637157
107Morphological abnormality of the pyramidal tract (HP:0002062)2.28207992
108Alacrima (HP:0000522)2.26964952
109Rapidly progressive (HP:0003678)2.25995074
110Mutism (HP:0002300)2.23805354
111Turricephaly (HP:0000262)2.22184787
112Frequent falls (HP:0002359)2.22168836
113Oligodactyly (hands) (HP:0001180)2.19949683
114Bundle branch block (HP:0011710)2.19132095
115Impulsivity (HP:0100710)2.16930888
116EEG with generalized epileptiform discharges (HP:0011198)2.15226248
117Renovascular hypertension (HP:0100817)2.12751764
118Abnormal social behavior (HP:0012433)2.11830766
119Impaired social interactions (HP:0000735)2.11830766
120Hyperacusis (HP:0010780)2.11472621
121Carpal bone hypoplasia (HP:0001498)2.08486452
122Spastic tetraparesis (HP:0001285)2.08059428
123Impaired smooth pursuit (HP:0007772)2.05367165
124Abnormal large intestine physiology (HP:0012700)2.03631586
125Leukodystrophy (HP:0002415)2.03150148
126Metaphyseal irregularity (HP:0003025)2.02329225
127Amblyopia (HP:0000646)2.01138107
128Incomplete penetrance (HP:0003829)2.00245180
129Progressive cerebellar ataxia (HP:0002073)1.99635681
130Peripheral demyelination (HP:0011096)1.99606483
131Memory impairment (HP:0002354)1.99516248
132Impaired vibratory sensation (HP:0002495)1.98698892
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97903438
134Morphological abnormality of the inner ear (HP:0011390)1.97898369
135Abnormality of the nasal mucosa (HP:0000433)1.97849298
136Hypsarrhythmia (HP:0002521)1.97716988
137Stereotypic behavior (HP:0000733)1.97609039
138Abnormality of the ischium (HP:0003174)1.97176940
139Vertebral fusion (HP:0002948)1.96481488
140Colon cancer (HP:0003003)1.94991136
141Nephronophthisis (HP:0000090)1.92552569
142Bowel incontinence (HP:0002607)1.92546575
143Dysdiadochokinesis (HP:0002075)1.91656046
144Ventricular fibrillation (HP:0001663)1.87458044
145Distal sensory impairment (HP:0002936)1.87421133
146Neonatal respiratory distress (HP:0002643)1.86696128
147Abnormality of ocular smooth pursuit (HP:0000617)1.86348144
148Dysmetria (HP:0001310)1.86327675
149Renal duplication (HP:0000075)1.86325911
150Short thorax (HP:0010306)1.86225574
151Decreased motor nerve conduction velocity (HP:0003431)1.85684433
152Hematochezia (HP:0002573)1.85640680
153Split foot (HP:0001839)1.84108242
154Postural instability (HP:0002172)1.83603312
155Bronchomalacia (HP:0002780)1.83426454
156Stridor (HP:0010307)1.83060323
157Supranuclear gaze palsy (HP:0000605)1.81307741
158Thickened helices (HP:0000391)1.80878749
159Abnormality of saccadic eye movements (HP:0000570)1.80315373
160Polyphagia (HP:0002591)1.79943452
161Facial hemangioma (HP:0000329)1.79799696
162Hepatocellular necrosis (HP:0001404)1.78103641
163Axonal loss (HP:0003447)1.77578037
164Fatigue (HP:0012378)1.76755610
165Flat cornea (HP:0007720)1.76373761
166Abnormality of the pubic bones (HP:0003172)1.75681410
167Clonus (HP:0002169)1.75069214
168Aplasia involving bones of the upper limbs (HP:0009823)1.72586488
169Aplasia of the phalanges of the hand (HP:0009802)1.72586488
170Aplasia involving bones of the extremities (HP:0009825)1.72586488
171Cholecystitis (HP:0001082)1.72022822
172Abnormal gallbladder physiology (HP:0012438)1.72022822
173Hypercalcemia (HP:0003072)1.70027185
174Abnormality of the sella turcica (HP:0002679)1.69477842
175Flat acetabular roof (HP:0003180)1.68838294
176Hypoplastic iliac wings (HP:0002866)1.66794477
177Hyporeflexia of lower limbs (HP:0002600)1.65323859
178Onion bulb formation (HP:0003383)1.65014961
179Spastic diplegia (HP:0001264)1.64805352
180Global brain atrophy (HP:0002283)1.64767470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.00360837
2CDK125.30564481
3TESK24.33095873
4PDK34.20718959
5PDK44.20718959
6BRD43.68740129
7DAPK23.54565113
8PDK22.75854743
9MAP2K22.72104348
10CAMK1G2.70043797
11MAP3K92.55362742
12MINK12.35169435
13RIPK41.95592566
14PLK21.85779603
15TESK11.76086576
16CAMK2B1.74931762
17CDK191.74929745
18STK381.66319430
19MAPK151.61096339
20CDK51.55963039
21ARAF1.50779295
22GRK11.43157993
23CAMK11.43043809
24PRPF4B1.40336961
25TLK11.33193681
26CAMK2G1.33109894
27LATS21.32132625
28STK391.31559496
29STK31.31315852
30WNK11.31286108
31KSR21.27312311
32DAPK11.25135935
33ICK1.23973924
34PRKCH1.22108425
35RIPK11.21121873
36MAPK131.18139481
37CASK1.17610844
38PTK2B1.16371478
39PAK31.15188831
40LATS11.12322593
41PHKG11.10407768
42PHKG21.10407768
43CAMK2A1.08203537
44CAMKK21.04461298
45CDK181.03747669
46SIK21.03172748
47OXSR11.02446081
48NEK21.01933708
49NTRK11.01635641
50STK110.99668821
51CDK11A0.98328295
52MELK0.98053948
53SGK20.98008768
54BMPR20.94810928
55CDK140.94440901
56PAK60.93917967
57DYRK1A0.92526875
58NEK60.92005817
59CAMK2D0.91515521
60MAPK120.91245825
61DAPK30.90755264
62ROCK20.90619518
63SGK30.86537271
64GRK50.84432901
65NTRK20.82317813
66SGK10.82288673
67AKT30.82107998
68MAP3K130.81753740
69EPHA20.79692346
70CDK70.79678913
71DDR20.76839180
72TYRO30.76195039
73PDK10.76096779
74BRSK10.72908530
75PKN20.70818083
76MAP3K110.69196598
77UHMK10.69159748
78TNK20.69159350
79ALK0.67377956
80CAMK1D0.66713461
81PINK10.66521038
82MAP3K40.66224992
83EPHA40.65262890
84RPS6KA30.64669414
85MTOR0.64338595
86LIMK10.64245304
87CAMK40.62419719
88PDPK10.62170478
89PKN10.61693637
90MARK20.60119061
91PRKCZ0.59531974
92TRIB30.58403568
93PAK20.58094482
94PRKD10.57107095
95WNK40.57036402
96VRK10.56380006
97CCNB10.55333366
98CHEK20.54580345
99MAPKAPK50.54339692
100CAMKK10.53732855
101FYN0.53305500
102GRK60.53254555
103MARK10.52901260
104PRKCG0.51508552
105NTRK30.48203417
106ZAK0.48006572
107PBK0.47868884
108FGR0.47848182
109MAP2K70.46120909
110FES0.45702791
111BCKDK0.45500756
112FGFR20.45141050
113NLK0.43558846
114BLK0.42787467
115CDK80.41319889
116WEE10.40528472
117PRKD30.39715010
118CDK90.39461732
119PRKG10.39345488
120PRKCA0.39301682
121BMPR1B0.39239458
122MAPK100.39145369
123MAP3K10.38988021
124ROCK10.38435846
125PDGFRB0.37715879
126PAK40.37649568
127KSR10.37210982
128NME10.36445077
129MAP3K20.35584310
130PAK10.35370029
131PRKG20.34607155
132RET0.34267829
133CHEK10.33810077
134PRKACB0.33712044
135IRAK20.33699079
136DMPK0.33014562
137RAF10.31754569
138SGK2230.30756664
139SGK4940.30756664
140TTN0.29502944
141STK160.28986789
142MAP2K40.28951471
143AKT20.28538328
144ERBB20.28183327
145PRKCE0.27830340
146LMTK20.27635753
147SRC0.27287416
148STK100.26395049
149CDC70.26384941
150PTK60.26140103
151GSK3B0.26023110
152BRAF0.23660197
153MAP2K10.21486288
154INSRR0.20892527
155PRKCI0.20826328
156PRKCQ0.20680334
157PIK3CA0.19689212
158PRKCB0.18874608
159MAPK10.18697322
160STK40.16645750
161CDK150.16433622

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009107.15334566
2Folate biosynthesis_Homo sapiens_hsa007902.72499064
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.23557974
4Pancreatic secretion_Homo sapiens_hsa049722.22988823
5Glycerolipid metabolism_Homo sapiens_hsa005611.92703636
6Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86889195
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86620548
8Histidine metabolism_Homo sapiens_hsa003401.75852958
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75065991
10Cholinergic synapse_Homo sapiens_hsa047251.73056341
11Cardiac muscle contraction_Homo sapiens_hsa042601.69639829
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56835038
13Vitamin B6 metabolism_Homo sapiens_hsa007501.52944287
14Pentose phosphate pathway_Homo sapiens_hsa000301.51306059
15Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.49998467
16Systemic lupus erythematosus_Homo sapiens_hsa053221.48920516
17Bile secretion_Homo sapiens_hsa049761.48545174
18Fatty acid biosynthesis_Homo sapiens_hsa000611.41826879
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41346154
20Selenocompound metabolism_Homo sapiens_hsa004501.40154115
21Gastric acid secretion_Homo sapiens_hsa049711.38211165
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.33900028
23Amphetamine addiction_Homo sapiens_hsa050311.33618423
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.33211507
25Alcoholism_Homo sapiens_hsa050341.32348003
26Salivary secretion_Homo sapiens_hsa049701.30224157
27Glutamatergic synapse_Homo sapiens_hsa047241.29226106
28Long-term depression_Homo sapiens_hsa047301.26372339
29GnRH signaling pathway_Homo sapiens_hsa049121.25896574
30Nicotine addiction_Homo sapiens_hsa050331.25575727
31Biosynthesis of amino acids_Homo sapiens_hsa012301.25275072
32Huntingtons disease_Homo sapiens_hsa050161.23584848
33Protein digestion and absorption_Homo sapiens_hsa049741.22423054
34Taste transduction_Homo sapiens_hsa047421.19957761
35Fat digestion and absorption_Homo sapiens_hsa049751.19158264
36Dorso-ventral axis formation_Homo sapiens_hsa043201.15571323
37Pyruvate metabolism_Homo sapiens_hsa006201.15191277
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12981895
39Arginine biosynthesis_Homo sapiens_hsa002201.12945771
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12050357
41Olfactory transduction_Homo sapiens_hsa047401.11269501
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10440471
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07704832
44Glioma_Homo sapiens_hsa052141.07296039
45beta-Alanine metabolism_Homo sapiens_hsa004101.07062953
46Synaptic vesicle cycle_Homo sapiens_hsa047211.06584635
47Insulin secretion_Homo sapiens_hsa049111.05262943
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99675684
49Melanogenesis_Homo sapiens_hsa049160.99405620
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95716297
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91338000
52Prion diseases_Homo sapiens_hsa050200.89455181
53ABC transporters_Homo sapiens_hsa020100.89050221
54GABAergic synapse_Homo sapiens_hsa047270.87764285
55Long-term potentiation_Homo sapiens_hsa047200.87598917
56Serotonergic synapse_Homo sapiens_hsa047260.87420799
57Gap junction_Homo sapiens_hsa045400.87052966
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.86344479
59Thyroid hormone synthesis_Homo sapiens_hsa049180.84656132
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82981651
61AMPK signaling pathway_Homo sapiens_hsa041520.82172023
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.81886674
63Basal transcription factors_Homo sapiens_hsa030220.81124214
64Rap1 signaling pathway_Homo sapiens_hsa040150.80732661
65Linoleic acid metabolism_Homo sapiens_hsa005910.80562525
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79392767
67ErbB signaling pathway_Homo sapiens_hsa040120.78963558
68Propanoate metabolism_Homo sapiens_hsa006400.78289502
69Renin secretion_Homo sapiens_hsa049240.77121881
70Oocyte meiosis_Homo sapiens_hsa041140.77015466
71Cocaine addiction_Homo sapiens_hsa050300.76601282
72Glucagon signaling pathway_Homo sapiens_hsa049220.75459624
73Sphingolipid metabolism_Homo sapiens_hsa006000.74813872
74Vibrio cholerae infection_Homo sapiens_hsa051100.74350766
75Renin-angiotensin system_Homo sapiens_hsa046140.74305304
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73550800
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72844026
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72634339
79Phototransduction_Homo sapiens_hsa047440.72562362
80Ras signaling pathway_Homo sapiens_hsa040140.72531043
81Mineral absorption_Homo sapiens_hsa049780.72081859
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71331299
83MAPK signaling pathway_Homo sapiens_hsa040100.70994309
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.70332504
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69831415
86Endocytosis_Homo sapiens_hsa041440.69160800
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.68793904
88Oxidative phosphorylation_Homo sapiens_hsa001900.67962767
89cAMP signaling pathway_Homo sapiens_hsa040240.67644228
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.65831159
91VEGF signaling pathway_Homo sapiens_hsa043700.64789354
92Carbon metabolism_Homo sapiens_hsa012000.63951117
93Axon guidance_Homo sapiens_hsa043600.63746130
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63046238
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62850498
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62419967
97Colorectal cancer_Homo sapiens_hsa052100.60987016
98Calcium signaling pathway_Homo sapiens_hsa040200.60141708
99Collecting duct acid secretion_Homo sapiens_hsa049660.59744167
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59038271
101Fructose and mannose metabolism_Homo sapiens_hsa000510.58906800
102Morphine addiction_Homo sapiens_hsa050320.58787027
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58132750
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57446851
105Glutathione metabolism_Homo sapiens_hsa004800.55132887
106Type II diabetes mellitus_Homo sapiens_hsa049300.54166759
107mTOR signaling pathway_Homo sapiens_hsa041500.52633656
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52609469
109Estrogen signaling pathway_Homo sapiens_hsa049150.52056894
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51613423
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49960736
112Arginine and proline metabolism_Homo sapiens_hsa003300.48250052
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47478675
114Choline metabolism in cancer_Homo sapiens_hsa052310.47173679
115Alzheimers disease_Homo sapiens_hsa050100.45818776
116Butanoate metabolism_Homo sapiens_hsa006500.44670010
117Dilated cardiomyopathy_Homo sapiens_hsa054140.41665857
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40894371
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39554282
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.39551885
121mRNA surveillance pathway_Homo sapiens_hsa030150.39422589
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39154441
123p53 signaling pathway_Homo sapiens_hsa041150.38517928
124Oxytocin signaling pathway_Homo sapiens_hsa049210.38441378
125Circadian rhythm_Homo sapiens_hsa047100.38236483
126Hedgehog signaling pathway_Homo sapiens_hsa043400.37903023
127Ether lipid metabolism_Homo sapiens_hsa005650.37257150
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.37036549
129Hippo signaling pathway_Homo sapiens_hsa043900.36086558
130Tight junction_Homo sapiens_hsa045300.35091771
131Inositol phosphate metabolism_Homo sapiens_hsa005620.33175133
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32288637
133Ovarian steroidogenesis_Homo sapiens_hsa049130.31798089
134Circadian entrainment_Homo sapiens_hsa047130.31066252
135Dopaminergic synapse_Homo sapiens_hsa047280.30916325
136Wnt signaling pathway_Homo sapiens_hsa043100.29874233
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24817230
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20717638

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