TMEM236

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)7.06641654
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.67849426
33-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.02090915
4purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.02090915
5flavonoid metabolic process (GO:0009812)6.01990215
6sulfate transmembrane transport (GO:1902358)5.94527692
7adhesion of symbiont to host cell (GO:0044650)5.79057882
8virion attachment to host cell (GO:0019062)5.79057882
9actin filament depolymerization (GO:0030042)5.74712765
10digestive system process (GO:0022600)5.64231831
11UDP-N-acetylglucosamine metabolic process (GO:0006047)5.48950298
12maintenance of gastrointestinal epithelium (GO:0030277)5.32072986
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.17540764
14sulfate transport (GO:0008272)5.06347658
15drug catabolic process (GO:0042737)5.02223054
16L-fucose catabolic process (GO:0042355)4.82720350
17fucose catabolic process (GO:0019317)4.82720350
18L-fucose metabolic process (GO:0042354)4.82720350
19regulation of bile acid biosynthetic process (GO:0070857)4.82407948
20adhesion of symbiont to host (GO:0044406)4.62726072
21sulfation (GO:0051923)4.58651311
22phospholipid efflux (GO:0033700)4.35247731
23digestion (GO:0007586)4.23926721
24intestinal epithelial cell development (GO:0060576)4.22742504
25bile acid and bile salt transport (GO:0015721)4.21380816
26sulfur compound transport (GO:0072348)4.21358660
27plasma lipoprotein particle assembly (GO:0034377)4.20393534
28modified amino acid transport (GO:0072337)4.14446019
29drinking behavior (GO:0042756)4.13745130
30O-glycan processing (GO:0016266)4.13537523
31positive regulation of triglyceride lipase activity (GO:0061365)4.10192266
32positive regulation of lipoprotein lipase activity (GO:0051006)4.10192266
33cellular ketone body metabolic process (GO:0046950)4.10112562
34cellular response to hepatocyte growth factor stimulus (GO:0035729)4.09571188
35response to hepatocyte growth factor (GO:0035728)4.09571188
36very-low-density lipoprotein particle assembly (GO:0034379)4.08329828
37regulation of guanylate cyclase activity (GO:0031282)4.05399203
38protein-lipid complex assembly (GO:0065005)4.00851205
39peptide hormone processing (GO:0016486)4.00739989
40glucose 6-phosphate metabolic process (GO:0051156)3.97997420
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97418617
42bicarbonate transport (GO:0015701)3.87428068
43sperm capacitation (GO:0048240)3.87349205
44regulation of cholesterol esterification (GO:0010872)3.85209851
45lipoprotein metabolic process (GO:0042157)3.84173065
46regulation of triglyceride catabolic process (GO:0010896)3.79610154
47thyroid hormone metabolic process (GO:0042403)3.76761028
48oligosaccharide catabolic process (GO:0009313)3.74200890
49cholesterol efflux (GO:0033344)3.74064704
50regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.72813950
51epithelial structure maintenance (GO:0010669)3.71688808
52behavioral response to nicotine (GO:0035095)3.71478728
53positive regulation of T cell differentiation in thymus (GO:0033089)3.68580876
54hormone catabolic process (GO:0042447)3.64667906
55ketone body metabolic process (GO:1902224)3.63600732
56lipoprotein transport (GO:0042953)3.63279794
57negative regulation of cholesterol transport (GO:0032375)3.61443874
58negative regulation of sterol transport (GO:0032372)3.61443874
59sphingomyelin metabolic process (GO:0006684)3.60424704
60positive regulation of guanylate cyclase activity (GO:0031284)3.58458872
61transepithelial transport (GO:0070633)3.52927142
62indolalkylamine metabolic process (GO:0006586)3.50934031
63regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.49232985
64endocrine process (GO:0050886)3.49232985
65regulation of systemic arterial blood pressure by hormone (GO:0001990)3.49232985
66respiratory chain complex IV assembly (GO:0008535)3.44713429
67peptide catabolic process (GO:0043171)3.41786686
68proline transport (GO:0015824)3.41070836
69sterol transport (GO:0015918)3.34275339
70cholesterol transport (GO:0030301)3.34275339
71water-soluble vitamin biosynthetic process (GO:0042364)3.32862982
72indole-containing compound catabolic process (GO:0042436)3.32524445
73indolalkylamine catabolic process (GO:0046218)3.32524445
74tryptophan catabolic process (GO:0006569)3.32524445
75cholesterol homeostasis (GO:0042632)3.31287094
76sterol homeostasis (GO:0055092)3.28531520
77diacylglycerol metabolic process (GO:0046339)3.23241471
78cellular glucuronidation (GO:0052695)3.22096113
79response to pheromone (GO:0019236)3.20875868
80nucleotide-sugar biosynthetic process (GO:0009226)3.17357924
81phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15063518
82purine nucleotide salvage (GO:0032261)3.14698169
83regulation of actin nucleation (GO:0051125)3.12616383
84hepatocyte apoptotic process (GO:0097284)3.11115230
85tryptophan metabolic process (GO:0006568)3.10729026
86epoxygenase P450 pathway (GO:0019373)3.09584545
87cytochrome complex assembly (GO:0017004)3.09470853
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08076104
89kidney morphogenesis (GO:0060993)3.07459487
90auditory receptor cell differentiation (GO:0042491)3.06573867
91nucleotide-sugar metabolic process (GO:0009225)2.99998452
92transcytosis (GO:0045056)2.97605965
93plasma lipoprotein particle organization (GO:0071827)2.97487273
94regulation of systemic arterial blood pressure (GO:0003073)2.96200843
95adenosine metabolic process (GO:0046085)2.95440796
96polyol transport (GO:0015791)2.94916101
97platelet dense granule organization (GO:0060155)2.94903230
98phosphatidylinositol acyl-chain remodeling (GO:0036149)2.94190554
99protein-lipid complex subunit organization (GO:0071825)2.94069550
100protein-lipid complex remodeling (GO:0034368)2.93293571
101macromolecular complex remodeling (GO:0034367)2.93293571
102plasma lipoprotein particle remodeling (GO:0034369)2.93293571
103uronic acid metabolic process (GO:0006063)2.92586331
104glucuronate metabolic process (GO:0019585)2.92586331
105striated muscle atrophy (GO:0014891)2.92497630
106arginine metabolic process (GO:0006525)2.91465832
107histamine secretion (GO:0001821)2.90918820
108signal peptide processing (GO:0006465)2.90746373
109photoreceptor cell maintenance (GO:0045494)2.86577184
110positive regulation of fatty acid transport (GO:2000193)2.86141804
111negative regulation of keratinocyte proliferation (GO:0010839)2.85796782
112detection of light stimulus involved in visual perception (GO:0050908)2.84524374
113detection of light stimulus involved in sensory perception (GO:0050962)2.84524374
114cellular anion homeostasis (GO:0030002)2.84155575
115positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.83676108
116negative regulation of execution phase of apoptosis (GO:1900118)2.81428551
117nucleobase catabolic process (GO:0046113)2.81013012
118kynurenine metabolic process (GO:0070189)2.80225696
119reverse cholesterol transport (GO:0043691)2.79252117
120regulation of viral release from host cell (GO:1902186)2.78866001
121exogenous drug catabolic process (GO:0042738)2.78704858
122protein K11-linked deubiquitination (GO:0035871)2.77759686
123fucosylation (GO:0036065)2.76625106
124quinone biosynthetic process (GO:1901663)2.76541702
125receptor guanylyl cyclase signaling pathway (GO:0007168)2.74055521
126thrombin receptor signaling pathway (GO:0070493)2.73055665
127drug metabolic process (GO:0017144)2.72383382
128vitamin biosynthetic process (GO:0009110)2.72191127
129phospholipid scrambling (GO:0017121)2.71744960
130alkaloid metabolic process (GO:0009820)2.69016021
131cornea development in camera-type eye (GO:0061303)2.68585291
132activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.67378610
133positive regulation of fatty acid biosynthetic process (GO:0045723)2.65867587
134lung secretory cell differentiation (GO:0061140)2.65825669
135regulation of cholesterol homeostasis (GO:2000188)2.65320649
136regulation of digestive system process (GO:0044058)2.64645008
137mucosal immune response (GO:0002385)2.63390395
138negative regulation of digestive system process (GO:0060457)2.63305871
139piRNA metabolic process (GO:0034587)2.61509833
140phosphatidylserine acyl-chain remodeling (GO:0036150)2.61416774
141heme transport (GO:0015886)2.61275722
142cytidine metabolic process (GO:0046087)2.60970571
143cytidine catabolic process (GO:0006216)2.60970571
144cytidine deamination (GO:0009972)2.60970571
145regulation of cGMP biosynthetic process (GO:0030826)2.60419196
146indole-containing compound metabolic process (GO:0042430)2.60138343
147endocrine pancreas development (GO:0031018)2.58837541
148DNA deamination (GO:0045006)2.58072915
149axoneme assembly (GO:0035082)2.57903745
150primary amino compound metabolic process (GO:1901160)2.56060253
151positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53959494
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53601490
153basic amino acid transport (GO:0015802)2.52980743
154nitric oxide biosynthetic process (GO:0006809)2.51938248
155positive regulation of icosanoid secretion (GO:0032305)2.51912892
156regulation of protein glycosylation (GO:0060049)2.51821290
157auditory receptor cell stereocilium organization (GO:0060088)2.50246988
158eosinophil chemotaxis (GO:0048245)2.48210852
159glycerophospholipid catabolic process (GO:0046475)2.46702223
160nephron epithelium morphogenesis (GO:0072088)2.45780190
161nephron tubule morphogenesis (GO:0072078)2.45780190
162polyol catabolic process (GO:0046174)2.45527767
163regulation of hexokinase activity (GO:1903299)2.45450652
164regulation of glucokinase activity (GO:0033131)2.45450652
165insulin secretion (GO:0030073)2.44684419
166oxidative demethylation (GO:0070989)2.42883440
167alanine transport (GO:0032328)2.42439615
168glycerol metabolic process (GO:0006071)2.42374692
169S-adenosylmethionine metabolic process (GO:0046500)2.41422560
170positive regulation of prostaglandin secretion (GO:0032308)2.39991611
171reflex (GO:0060004)2.39846867
172amine catabolic process (GO:0009310)2.38474840
173cellular biogenic amine catabolic process (GO:0042402)2.38474840
174protein complex biogenesis (GO:0070271)2.37796691
175phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.36763674
176serotonin metabolic process (GO:0042428)2.35819527
177phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.35124510
178intestinal absorption (GO:0050892)11.8601415
179intestinal cholesterol absorption (GO:0030299)10.8732109
180angiotensin maturation (GO:0002003)10.1302402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.41881861
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.49547729
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.33098991
4ZNF274_21170338_ChIP-Seq_K562_Hela3.32951202
5CDX2_19796622_ChIP-Seq_MESCs_Mouse3.05058913
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02026336
7GATA4_25053715_ChIP-Seq_YYC3_Human2.87027001
8SOX2_20726797_ChIP-Seq_SW620_Human2.64232774
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58816547
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.54331428
11GBX2_23144817_ChIP-Seq_PC3_Human2.52072451
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51528503
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47599676
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44772619
15GATA6_25053715_ChIP-Seq_YYC3_Human2.43704384
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.20941164
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12019386
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09587239
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.04816416
20IGF1R_20145208_ChIP-Seq_DFB_Human2.03287147
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92805132
22P300_19829295_ChIP-Seq_ESCs_Human1.90942438
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88862693
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88657099
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87599473
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84412434
27FUS_26573619_Chip-Seq_HEK293_Human1.82621601
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81678776
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80843931
30ER_23166858_ChIP-Seq_MCF-7_Human1.78635448
31KLF5_25053715_ChIP-Seq_YYC3_Human1.76467409
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73763349
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71318744
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.69756240
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.66028368
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.61778293
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61288471
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.58874583
39EWS_26573619_Chip-Seq_HEK293_Human1.53958572
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53200103
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52713872
42STAT3_23295773_ChIP-Seq_U87_Human1.52093997
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51665595
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49130574
45TAF15_26573619_Chip-Seq_HEK293_Human1.48916472
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48413754
47TCF4_22108803_ChIP-Seq_LS180_Human1.48136022
48SMAD4_21799915_ChIP-Seq_A2780_Human1.47401710
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45422096
50TCF4_23295773_ChIP-Seq_U87_Human1.44924729
51VDR_22108803_ChIP-Seq_LS180_Human1.43715644
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43491227
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43314556
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.43187604
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43187604
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42931672
57CBP_20019798_ChIP-Seq_JUKART_Human1.42931672
58AR_25329375_ChIP-Seq_VCAP_Human1.42881969
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42578818
60NANOG_19829295_ChIP-Seq_ESCs_Human1.39429418
61SOX2_19829295_ChIP-Seq_ESCs_Human1.39429418
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39210910
63TP53_22573176_ChIP-Seq_HFKS_Human1.39026600
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38454900
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37760126
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.35816373
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33998201
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.33960151
69AR_20517297_ChIP-Seq_VCAP_Human1.31987580
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.31892900
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31819132
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.31693670
73GATA2_19941826_ChIP-Seq_K562_Human1.29868374
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28766551
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26640765
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26163597
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26078239
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.25691378
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.24928537
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24341566
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22700079
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22677471
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.22095269
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20923869
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.20847015
86NCOR_22424771_ChIP-Seq_293T_Human1.20693650
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20075247
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19432975
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19397546
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19239282
91DROSHA_22980978_ChIP-Seq_HELA_Human1.18840885
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.18235494
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16075005
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.15200508
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.15200308
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14416854
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14234319
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14234319
99REST_21632747_ChIP-Seq_MESCs_Mouse1.14111886
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.13924689
101P53_22387025_ChIP-Seq_ESCs_Mouse1.13194630
102RUNX2_22187159_ChIP-Seq_PCA_Human1.12276975
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11434450
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.11382925
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.11150544
106GATA1_22025678_ChIP-Seq_K562_Human1.10760844
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09760275
108CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09717444
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.09687368
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09601857
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09310071
112HOXB7_26014856_ChIP-Seq_BT474_Human1.08824073
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08409258
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07939610
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05353090
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05263953
117IRF1_19129219_ChIP-ChIP_H3396_Human1.04917358
118EZH2_22144423_ChIP-Seq_EOC_Human1.04099954
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03434137
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.03364586
121HNF4A_19822575_ChIP-Seq_HepG2_Human1.03195842
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.02475539
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01302908
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00233858
125AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00078011
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.99811274
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98729972
128CDX2_22108803_ChIP-Seq_LS180_Human0.96951685
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96599955
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.95521972
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.94692758
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93418529
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93225728
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.92557039
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.92242513
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90763275
137RXR_22108803_ChIP-Seq_LS180_Human0.90352280
138CJUN_26792858_Chip-Seq_BT549_Human0.89994876
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89359933
140BCAT_22108803_ChIP-Seq_LS180_Human0.88951028
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88886350
142TP53_16413492_ChIP-PET_HCT116_Human0.87580272
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87161303
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.86532481
145EGR1_19032775_ChIP-ChIP_M12_Human0.85986461
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.85293435
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85206434
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83606172
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82598333
150SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82481440
151SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82481440
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82233375
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.81968077
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81289903
155NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80926228
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80484202
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78920450
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78481013
159MYC_19829295_ChIP-Seq_ESCs_Human0.78259004
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78135287
161NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77882033
162P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77277219
163SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76852231
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.75926654
165TAL1_26923725_Chip-Seq_HPCs_Mouse0.75375540
166RACK7_27058665_Chip-Seq_MCF-7_Human0.75349983
167JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75102049
168TP63_23658742_ChIP-Seq_EP156T_Human0.75049725
169TP53_18474530_ChIP-ChIP_U2OS_Human0.74930206
170FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74911820
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.74346500
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73637006
173THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73458458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.18623360
2MP0001666_abnormal_nutrient_absorption5.97112420
3MP0003183_abnormal_peptide_metabolism3.93916821
4MP0003195_calcinosis3.64115244
5MP0004264_abnormal_extraembryonic_tissu3.58893368
6MP0002822_catalepsy3.53010159
7MP0005377_hearing/vestibular/ear_phenot3.50262841
8MP0003878_abnormal_ear_physiology3.50262841
9MP0000462_abnormal_digestive_system3.42078618
10MP0003866_abnormal_defecation3.29248938
11MP0008875_abnormal_xenobiotic_pharmacok3.15714497
12MP0010234_abnormal_vibrissa_follicle3.11192700
13MP0002139_abnormal_hepatobiliary_system2.97961347
14MP0005085_abnormal_gallbladder_physiolo2.92265627
15MP0002837_dystrophic_cardiac_calcinosis2.77091945
16MP0003252_abnormal_bile_duct2.64112394
17MP0009840_abnormal_foam_cell2.57780819
18MP0001663_abnormal_digestive_system2.34912719
19MP0005381_digestive/alimentary_phenotyp2.29434279
20MP0010155_abnormal_intestine_physiology2.27142988
21MP0004147_increased_porphyrin_level2.18775932
22MP0005645_abnormal_hypothalamus_physiol2.17108849
23MP0001501_abnormal_sleep_pattern2.16514933
24MP0001873_stomach_inflammation2.12091587
25MP0001664_abnormal_digestion2.09302105
26MP0000569_abnormal_digit_pigmentation2.07302797
27MP0010329_abnormal_lipoprotein_level2.06867391
28MP0004019_abnormal_vitamin_homeostasis2.06530856
29MP0005551_abnormal_eye_electrophysiolog2.05560031
30MP0005174_abnormal_tail_pigmentation1.96072944
31MP0008877_abnormal_DNA_methylation1.95308458
32MP0009697_abnormal_copulation1.93468851
33MP0000490_abnormal_crypts_of1.92736328
34MP0003283_abnormal_digestive_organ1.91055272
35MP0004043_abnormal_pH_regulation1.87003397
36MP0005084_abnormal_gallbladder_morpholo1.81706749
37MP0000538_abnormal_urinary_bladder1.80678662
38MP0000477_abnormal_intestine_morphology1.79144616
39MP0005646_abnormal_pituitary_gland1.72876272
40MP0005379_endocrine/exocrine_gland_phen1.70233658
41MP0006072_abnormal_retinal_apoptosis1.65495571
42MP0000537_abnormal_urethra_morphology1.64778089
43MP0005167_abnormal_blood-brain_barrier1.64383913
44MP0010352_gastrointestinal_tract_polyps1.59633025
45MP0002909_abnormal_adrenal_gland1.57283712
46MP0002163_abnormal_gland_morphology1.56425010
47MP0005365_abnormal_bile_salt1.53785485
48MP0002138_abnormal_hepatobiliary_system1.53713240
49MP0001986_abnormal_taste_sensitivity1.49045744
50MP0009379_abnormal_foot_pigmentation1.41228788
51MP0002876_abnormal_thyroid_physiology1.39368002
52MP0005253_abnormal_eye_physiology1.35969484
53MP0005448_abnormal_energy_balance1.33590010
54MP0003646_muscle_fatigue1.33405477
55MP0002693_abnormal_pancreas_physiology1.31829294
56MP0009745_abnormal_behavioral_response1.31615737
57MP0001756_abnormal_urination1.30586208
58MP0000372_irregular_coat_pigmentation1.29886183
59MP0002938_white_spotting1.29726670
60MP0003300_gastrointestinal_ulcer1.28107527
61MP0003868_abnormal_feces_composition1.27775920
62MP0000015_abnormal_ear_pigmentation1.27682706
63MP0001485_abnormal_pinna_reflex1.26652142
64MP0003011_delayed_dark_adaptation1.26305315
65MP0009046_muscle_twitch1.24180031
66MP0004885_abnormal_endolymph1.22816287
67MP0002638_abnormal_pupillary_reflex1.20806464
68MP0001968_abnormal_touch/_nociception1.19567138
69MP0002102_abnormal_ear_morphology1.15269833
70MP0003787_abnormal_imprinting1.14230763
71MP0000013_abnormal_adipose_tissue1.14220326
72MP0009384_cardiac_valve_regurgitation1.11361302
73MP0002089_abnormal_postnatal_growth/wei1.11010395
74MP0004215_abnormal_myocardial_fiber1.10680878
75MP0005451_abnormal_body_composition1.08940910
76MP0006054_spinal_hemorrhage1.06969358
77MP0004924_abnormal_behavior1.06856194
78MP0005386_behavior/neurological_phenoty1.06856194
79MP0002272_abnormal_nervous_system1.04863046
80MP0000566_synostosis1.02887618
81MP0010386_abnormal_urinary_bladder1.02152473
82MP0002277_abnormal_respiratory_mucosa1.02101210
83MP0005075_abnormal_melanosome_morpholog1.01707408
84MP0004947_skin_inflammation1.00703680
85MP0002796_impaired_skin_barrier0.99988935
86MP0003705_abnormal_hypodermis_morpholog0.98090787
87MP0009643_abnormal_urine_homeostasis0.98026050
88MP0002098_abnormal_vibrissa_morphology0.97143071
89MP0002078_abnormal_glucose_homeostasis0.96777396
90MP0001944_abnormal_pancreas_morphology0.96032748
91MP0002733_abnormal_thermal_nociception0.95632266
92MP0001984_abnormal_olfaction0.94939577
93MP0005310_abnormal_salivary_gland0.94912576
94MP0000467_abnormal_esophagus_morphology0.94651655
95MP0003191_abnormal_cellular_cholesterol0.94030313
96MP0003953_abnormal_hormone_level0.93376423
97MP0005367_renal/urinary_system_phenotyp0.93178442
98MP0000516_abnormal_urinary_system0.93178442
99MP0001765_abnormal_ion_homeostasis0.92520346
100MP0002064_seizures0.91990514
101MP0000631_abnormal_neuroendocrine_gland0.91391287
102MP0002557_abnormal_social/conspecific_i0.90847052
103MP0001970_abnormal_pain_threshold0.90528911
104MP0005166_decreased_susceptibility_to0.90073796
105MP0004142_abnormal_muscle_tone0.88525664
106MP0008775_abnormal_heart_ventricle0.87011571
107MP0009780_abnormal_chondrocyte_physiolo0.86853584
108MP0005410_abnormal_fertilization0.86813949
109MP0001529_abnormal_vocalization0.86031976
110MP0003880_abnormal_central_pattern0.85794941
111MP0010678_abnormal_skin_adnexa0.85757638
112MP0002254_reproductive_system_inflammat0.83563695
113MP0002118_abnormal_lipid_homeostasis0.81964684
114MP0002572_abnormal_emotion/affect_behav0.81917381
115MP0000383_abnormal_hair_follicle0.81530748
116MP0005535_abnormal_body_temperature0.80943865
117MP0002148_abnormal_hypersensitivity_rea0.79350238
118MP0002095_abnormal_skin_pigmentation0.77577108
119MP0003879_abnormal_hair_cell0.77263113
120MP0002229_neurodegeneration0.75095009
121MP0003950_abnormal_plasma_membrane0.74465064
122MP0000678_abnormal_parathyroid_gland0.73179353
123MP0002736_abnormal_nociception_after0.72511830
124MP0000470_abnormal_stomach_morphology0.71006204
125MP0005636_abnormal_mineral_homeostasis0.69744038
126MP0002132_abnormal_respiratory_system0.67298325
127MP0000609_abnormal_liver_physiology0.66140060
128MP0004270_analgesia0.65734287
129MP0008872_abnormal_physiological_respon0.64903495
130MP0008004_abnormal_stomach_pH0.64137584
131MP0001188_hyperpigmentation0.63486437
132MP0002136_abnormal_kidney_physiology0.63350196
133MP0003941_abnormal_skin_development0.62218174
134MP0004484_altered_response_of0.61831962
135MP0001849_ear_inflammation0.60943238
136MP0005501_abnormal_skin_physiology0.58216434
137MP0005332_abnormal_amino_acid0.55635676
138MP0005409_darkened_coat_color0.54318836
139MP0001216_abnormal_epidermal_layer0.53383912
140MP0001845_abnormal_inflammatory_respons0.52458153
141MP0003806_abnormal_nucleotide_metabolis0.51916000
142MP0009115_abnormal_fat_cell0.50998915
143MP0005319_abnormal_enzyme/_coenzyme0.50163342
144MP0009785_altered_susceptibility_to0.48691950
145MP0003718_maternal_effect0.47843852
146MP0009642_abnormal_blood_homeostasis0.47413591
147MP0002009_preneoplasia0.47294131
148MP0000230_abnormal_systemic_arterial0.47240289
149MP0003453_abnormal_keratinocyte_physiol0.46427930
150MP0005266_abnormal_metabolism0.45685570
151MP0009053_abnormal_anal_canal0.45507064
152MP0001764_abnormal_homeostasis0.45395852
153MP0000427_abnormal_hair_cycle0.44851322
154MP0009765_abnormal_xenobiotic_induced0.44723780
155MP0000613_abnormal_salivary_gland0.43228379
156MP0001191_abnormal_skin_condition0.41635207
157MP0009764_decreased_sensitivity_to0.40612513
158MP0003315_abnormal_perineum_morphology0.39220969

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.10391793
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.09925049
3Cupped ribs (HP:0000887)5.85390530
4Conjugated hyperbilirubinemia (HP:0002908)5.66972949
5Acanthocytosis (HP:0001927)5.50460527
6Right ventricular cardiomyopathy (HP:0011663)5.32213885
7Hydroxyprolinuria (HP:0003080)5.13414016
8Abnormality of proline metabolism (HP:0010907)5.13414016
9Autoimmune thrombocytopenia (HP:0001973)4.95974904
10Chronic diarrhea (HP:0002028)4.87016033
11Hypobetalipoproteinemia (HP:0003563)4.86326638
12Malnutrition (HP:0004395)4.73154140
13Abdominal distention (HP:0003270)4.31574986
14Flat acetabular roof (HP:0003180)4.15809063
15Autoimmune hemolytic anemia (HP:0001890)3.94356061
16Widely patent fontanelles and sutures (HP:0004492)3.64957305
17Congenital stationary night blindness (HP:0007642)3.61533167
18Fat malabsorption (HP:0002630)3.58302270
19Pancreatic cysts (HP:0001737)3.56085048
20Hyperactive renin-angiotensin system (HP:0000841)3.48543209
21Hyperventilation (HP:0002883)3.43113587
22Pigmentary retinal degeneration (HP:0001146)3.42741592
23Abnormality of the renal cortex (HP:0011035)3.40734837
24Metabolic alkalosis (HP:0200114)3.28084938
25Pancreatic fibrosis (HP:0100732)3.26745900
26Molar tooth sign on MRI (HP:0002419)3.25070575
27Abnormality of midbrain morphology (HP:0002418)3.25070575
28Abnormal tarsal ossification (HP:0008369)3.22874580
29True hermaphroditism (HP:0010459)3.19682998
30Poikilocytosis (HP:0004447)3.00480202
31Gastrointestinal dysmotility (HP:0002579)2.97168239
32Abnormality of the 1st metacarpal (HP:0010009)2.96681107
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.95520048
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.95218973
35Nephronophthisis (HP:0000090)2.90989675
36Hypolipoproteinemia (HP:0010981)2.86516526
37Congenital sensorineural hearing impairment (HP:0008527)2.85716233
38Dehydration (HP:0001944)2.85317672
39Abnormality of B cell number (HP:0010975)2.85209192
40B lymphocytopenia (HP:0010976)2.85209192
41Renal cortical cysts (HP:0000803)2.83507926
42Flattened epiphyses (HP:0003071)2.82958136
43Hypothermia (HP:0002045)2.81886304
44Attenuation of retinal blood vessels (HP:0007843)2.80862043
45Neonatal short-limb short stature (HP:0008921)2.77835412
46Mildly elevated creatine phosphokinase (HP:0008180)2.77716800
47Glycosuria (HP:0003076)2.77382459
48Abnormality of urine glucose concentration (HP:0011016)2.77382459
49Tubular atrophy (HP:0000092)2.77245499
50Abnormality of carpal bone ossification (HP:0006257)2.77101873
51Type II lissencephaly (HP:0007260)2.74480616
52Abnormality of the renal medulla (HP:0100957)2.68627415
53Abnormality of vitamin B metabolism (HP:0004340)2.68308359
54Hypoalbuminemia (HP:0003073)2.68290016
55Abnormal albumin level (HP:0012116)2.68290016
56Abnormality of chloride homeostasis (HP:0011422)2.66363954
57Large for gestational age (HP:0001520)2.65488586
58Increased IgE level (HP:0003212)2.62749929
59Severe combined immunodeficiency (HP:0004430)2.62251041
60Abnormal glucose tolerance (HP:0001952)2.58348114
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.56245797
62Progressive sensorineural hearing impairment (HP:0000408)2.55439389
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.54789766
64Gaze-evoked nystagmus (HP:0000640)2.52519082
65Medial flaring of the eyebrow (HP:0010747)2.50848934
66Abolished electroretinogram (ERG) (HP:0000550)2.49603019
67Methylmalonic aciduria (HP:0012120)2.49214488
68Abnormal foot bone ossification (HP:0010675)2.47111542
69Cheilitis (HP:0100825)2.45986535
70Flat capital femoral epiphysis (HP:0003370)2.44399569
71Thyroiditis (HP:0100646)2.42495977
72Pustule (HP:0200039)2.40849500
73Villous atrophy (HP:0011473)2.37926108
74Abnormality of small intestinal villus morphology (HP:0011472)2.37926108
75Abnormal rod and cone electroretinograms (HP:0008323)2.36691640
76Abnormality of the 2nd finger (HP:0004100)2.35033700
77Mesangial abnormality (HP:0001966)2.33201702
78Ketoacidosis (HP:0001993)2.33177348
79Intestinal atresia (HP:0011100)2.32094352
80Polydipsia (HP:0001959)2.31368964
81Abnormal drinking behavior (HP:0030082)2.31368964
82Curly hair (HP:0002212)2.30159754
83Syncope (HP:0001279)2.29613892
84Hyperglycinuria (HP:0003108)2.29040102
85Woolly hair (HP:0002224)2.28020561
86Ketosis (HP:0001946)2.27911350
87Combined immunodeficiency (HP:0005387)2.27893774
88Hypoproteinemia (HP:0003075)2.26971678
89Methylmalonic acidemia (HP:0002912)2.26426483
90Furrowed tongue (HP:0000221)2.26383018
91Palpitations (HP:0001962)2.25794205
92Abnormality of the phalanges of the hallux (HP:0010057)2.24930074
93Pendular nystagmus (HP:0012043)2.24348622
94Proximal tubulopathy (HP:0000114)2.24006707
95Potter facies (HP:0002009)2.22558561
96Facial shape deformation (HP:0011334)2.22558561
97Inability to walk (HP:0002540)2.22013762
98Irregular epiphyses (HP:0010582)2.21765211
99Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21200897
100Micronodular cirrhosis (HP:0001413)2.21197163
101Fair hair (HP:0002286)2.20740642
102Cystic liver disease (HP:0006706)2.19951393
103Abnormality of the gastric mucosa (HP:0004295)2.19772419
104Alopecia of scalp (HP:0002293)2.18974453
105Albinism (HP:0001022)2.16995944
106Abnormality of the middle phalanges of the toes (HP:0010183)2.15129309
107Abnormality of the proximal phalanges of the hand (HP:0009834)2.14821600
108Confusion (HP:0001289)2.14179374
109Abnormality of vitamin metabolism (HP:0100508)2.13976492
110Myopathic facies (HP:0002058)2.11084089
111Abnormal biliary tract morphology (HP:0012440)2.08847413
112Alkalosis (HP:0001948)2.08843816
113Abnormality of glycine metabolism (HP:0010895)2.08377501
114Abnormality of serine family amino acid metabolism (HP:0010894)2.08377501
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07882016
116Wide cranial sutures (HP:0010537)2.07421161
117Abnormal hand bone ossification (HP:0010660)2.07332400
118Congenital, generalized hypertrichosis (HP:0004540)2.05630716
119Increased mean platelet volume (HP:0011877)2.04014551
120Abnormality of renin-angiotensin system (HP:0000847)2.02945743
121Hyperparathyroidism (HP:0000843)2.01909157
122Nephrolithiasis (HP:0000787)2.00892099
123Short middle phalanx of finger (HP:0005819)1.99252677
124Stomach cancer (HP:0012126)1.99155030
125Progressive hearing impairment (HP:0001730)1.98842256
126Hypercholesterolemia (HP:0003124)1.98274450
127Vacuolated lymphocytes (HP:0001922)1.96907543
128Chorioretinal atrophy (HP:0000533)1.96356664
129Milia (HP:0001056)1.95830541
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.95690735
131Progressive inability to walk (HP:0002505)1.95647558
132Cone-rod dystrophy (HP:0000548)1.94887178
133Genu varum (HP:0002970)1.94681897
134Chronic hepatic failure (HP:0100626)1.94306217
135Hemiparesis (HP:0001269)1.92402512
136Decreased circulating renin level (HP:0003351)1.92087979
137Progressive macrocephaly (HP:0004481)1.90554321
138Decreased central vision (HP:0007663)1.90430544
139Progressive cerebellar ataxia (HP:0002073)1.90247896
140Aplasia/hypoplasia of the femur (HP:0005613)1.89778979
141Broad-based gait (HP:0002136)1.88864500
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.87290321
143Hypoplasia of the fovea (HP:0007750)1.87290321
144Hematochezia (HP:0002573)1.86966185
145Lethargy (HP:0001254)1.86917519
146Ureteral obstruction (HP:0006000)1.86074992
147Congenital hepatic fibrosis (HP:0002612)1.85659603
148Abnormal platelet volume (HP:0011876)1.85224107
149Acute necrotizing encephalopathy (HP:0006965)1.84853984
150Enlarged epiphyses (HP:0010580)1.84845921
151Ureteral stenosis (HP:0000071)1.83474991
152Rectal prolapse (HP:0002035)1.83458888
153Bony spicule pigmentary retinopathy (HP:0007737)1.83437372
154Abnormality of alanine metabolism (HP:0010916)1.83061387
155Hyperalaninemia (HP:0003348)1.83061387
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83061387
157Hypokalemia (HP:0002900)1.83038027
158Delayed epiphyseal ossification (HP:0002663)1.82727142
159Hyperaldosteronism (HP:0000859)1.81957867
160Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81844155
161Dicarboxylic aciduria (HP:0003215)1.81844155
162Symptomatic seizures (HP:0011145)1.81820554
163Epidermoid cyst (HP:0200040)1.81660536
164Goiter (HP:0000853)1.81649817
165Xanthomatosis (HP:0000991)1.81450861
166Relative macrocephaly (HP:0004482)1.80811726
167Abnormality of purine metabolism (HP:0004352)1.80769524
168Generalized hypopigmentation of hair (HP:0011358)1.80319074
169Mitochondrial inheritance (HP:0001427)1.80316041
170Spinal cord compression (HP:0002176)1.80225678
171Polyuria (HP:0000103)1.80166212
172Hepatic necrosis (HP:0002605)1.79770034
1733-Methylglutaconic aciduria (HP:0003535)1.79116768
174Abnormality of renal excretion (HP:0011036)1.77654345
175Acute encephalopathy (HP:0006846)1.77319377
176Metabolic acidosis (HP:0001942)1.76627302
177Abnormality of potassium homeostasis (HP:0011042)1.76235782
178Increased corneal curvature (HP:0100692)1.75918684
179Keratoconus (HP:0000563)1.75918684
180Generalized aminoaciduria (HP:0002909)1.74044452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.01927679
2MST1R5.73727150
3MST45.58405056
4ACVR1B5.01630965
5LMTK24.07296992
6NME13.72399465
7PRKG23.34878068
8ADRBK23.20756908
9AKT32.84993701
10WNK32.66860760
11PIK3CA2.49387607
12MAP4K22.41364291
13NUAK12.33191299
14WNK42.26269738
15MAP2K22.25041293
16DAPK22.18860698
17GRK62.02767937
18RIPK11.97455586
19EPHB21.96134206
20EPHA21.89940272
21STK391.88576865
22OXSR11.87272641
23ZAK1.83191378
24PINK11.75855761
25MET1.67752781
26MAP3K21.60866443
27PTK61.50684338
28MAPK131.45614413
29MAP3K121.44616981
30CAMKK21.43795619
31TESK11.36064976
32MAP3K101.32765871
33MAP3K41.30890797
34TLK11.30009357
35MYLK1.28133918
36LATS11.23315545
37PHKG21.18527907
38PHKG11.18527907
39TRIM281.17479080
40FGFR21.17418958
41TNIK1.17295717
42EPHA31.08757000
43DDR21.07674678
44TGFBR11.07217267
45IRAK31.06830787
46RIPK41.05092831
47MAP2K61.04439411
48NTRK31.04280659
49PBK1.03617242
50ADRBK11.02128037
51MAPKAPK31.00046781
52STK100.99493352
53PRKCI0.98086796
54NLK0.97302089
55TXK0.96474491
56MAP3K70.96389643
57EPHA40.95200215
58ERN10.90179506
59MAP3K140.84327617
60ERBB20.83241619
61PTK2B0.81774956
62MAP3K110.80854884
63MAP2K10.80287084
64MATK0.80175778
65PLK20.77765336
66FER0.77614597
67STK240.75765441
68PRKAA20.75747550
69INSRR0.73159695
70MKNK20.72775368
71PRKCG0.71656708
72GRK10.70357481
73MAP3K30.70275197
74PAK40.69451833
75IRAK10.68336797
76TAOK10.65795245
77CAMK2D0.64250031
78TAOK30.61850965
79CSNK1G10.61205252
80IRAK40.60349838
81IKBKB0.60321528
82ERBB30.59958549
83EPHB10.59278494
84BRD40.57418953
85CSK0.57393430
86MAP3K10.57387458
87TBK10.57292236
88KIT0.56238484
89PDK20.54897393
90BCKDK0.54433902
91CSNK1G20.53718403
92TEC0.52663451
93KSR20.52570874
94MAP3K80.52201487
95CAMK2A0.51599542
96CSNK1G30.51584970
97TYK20.50889634
98STK30.50350843
99PTK20.50175750
100ITK0.49350898
101YES10.49276688
102PRKCZ0.47662157
103BRSK20.47610607
104PNCK0.47605298
105PIM20.47053910
106TNK20.46970730
107GRK70.45154030
108PRKACA0.44740993
109MAPK110.44579393
110STK110.44558354
111CHUK0.44045099
112TESK20.43953585
113TTK0.43719985
114SIK30.42542153
115MUSK0.42381010
116CDK90.41444233
117LIMK10.41071703
118BLK0.39728776
119CAMK1D0.39246591
120MAP3K130.39103860
121FGFR30.38949947
122CSNK1A10.38339601
123EIF2AK30.37947554
124PRKAA10.37139126
125PRKCA0.36793715
126PAK30.36763060
127DYRK20.36591073
128BMX0.32881927
129CSNK1A1L0.32581076
130BMPR1B0.31969739
131DMPK0.31619396
132STK38L0.31513147
133PRKCD0.30591335
134CAMK2B0.30063387
135SYK0.30042894
136CAMK1G0.29755870
137MAP2K70.29692828
138GRK50.29475141
139MAPKAPK50.29160552
140CAMK10.29011829
141IKBKE0.28933016
142CASK0.28845719
143PRKCE0.28115263
144ROCK10.27784628
145PDPK10.27591680
146PRKCQ0.27455870
147TIE10.27270739
148CAMK2G0.27149134
149IGF1R0.26734590
150RPS6KA50.26359244
151SRC0.25238255
152ICK0.20656349
153BCR0.18592149
154CDC42BPA0.18357261
155ERBB40.17879018
156PRKACG0.17385846
157RPS6KB10.16908727
158FYN0.15931673
159MAPKAPK20.15605084
160TRPM70.14706587
161SGK30.14399322
162PRKG10.13706014
163PDK10.13649354
164BRAF0.13227853

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.63256859
2Mineral absorption_Homo sapiens_hsa049784.77176953
3Sulfur metabolism_Homo sapiens_hsa009204.30054621
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.27576268
5Renin-angiotensin system_Homo sapiens_hsa046144.25806881
6Vitamin digestion and absorption_Homo sapiens_hsa049773.46955329
7Galactose metabolism_Homo sapiens_hsa000522.78393797
8Caffeine metabolism_Homo sapiens_hsa002322.73780132
9Starch and sucrose metabolism_Homo sapiens_hsa005002.58690051
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40678079
11Protein digestion and absorption_Homo sapiens_hsa049742.33182499
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22844243
13Nitrogen metabolism_Homo sapiens_hsa009102.09243663
14Bile secretion_Homo sapiens_hsa049762.04060180
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.03357221
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99900651
17Folate biosynthesis_Homo sapiens_hsa007901.94860200
18Fructose and mannose metabolism_Homo sapiens_hsa000511.82847943
19Phototransduction_Homo sapiens_hsa047441.69509002
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63381182
21Histidine metabolism_Homo sapiens_hsa003401.59198757
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58004393
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51803496
24Sphingolipid metabolism_Homo sapiens_hsa006001.50171328
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49541414
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33094815
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31577015
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28236994
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27030245
30Glutathione metabolism_Homo sapiens_hsa004801.24654365
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.24354723
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23439367
33Propanoate metabolism_Homo sapiens_hsa006401.21559284
34PPAR signaling pathway_Homo sapiens_hsa033201.20289352
35Oxidative phosphorylation_Homo sapiens_hsa001901.19833948
36Asthma_Homo sapiens_hsa053101.16688232
37Type I diabetes mellitus_Homo sapiens_hsa049401.15645996
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12837402
39Linoleic acid metabolism_Homo sapiens_hsa005911.11831258
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11631739
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10697738
42Glycerolipid metabolism_Homo sapiens_hsa005611.01722600
43Protein export_Homo sapiens_hsa030600.97227560
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96655279
45Arachidonic acid metabolism_Homo sapiens_hsa005900.93462887
46Collecting duct acid secretion_Homo sapiens_hsa049660.86594396
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85263817
48Tryptophan metabolism_Homo sapiens_hsa003800.83659848
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.82923958
50ABC transporters_Homo sapiens_hsa020100.79420471
51Serotonergic synapse_Homo sapiens_hsa047260.78012244
52Pancreatic secretion_Homo sapiens_hsa049720.77534275
53Arginine and proline metabolism_Homo sapiens_hsa003300.74940805
54Nicotine addiction_Homo sapiens_hsa050330.74194094
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.73175191
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73127131
57Fatty acid biosynthesis_Homo sapiens_hsa000610.73061217
58Chemical carcinogenesis_Homo sapiens_hsa052040.66641304
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.66383516
60Ether lipid metabolism_Homo sapiens_hsa005650.65912471
61Ovarian steroidogenesis_Homo sapiens_hsa049130.62910079
62Retinol metabolism_Homo sapiens_hsa008300.60439684
63Taste transduction_Homo sapiens_hsa047420.60419770
64Fatty acid degradation_Homo sapiens_hsa000710.59442311
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59067604
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.58849046
67Tight junction_Homo sapiens_hsa045300.58525810
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58090195
69Parkinsons disease_Homo sapiens_hsa050120.57157263
70Morphine addiction_Homo sapiens_hsa050320.57127208
71Fatty acid metabolism_Homo sapiens_hsa012120.56566660
72Allograft rejection_Homo sapiens_hsa053300.55315424
73Thyroid hormone synthesis_Homo sapiens_hsa049180.54090086
74Graft-versus-host disease_Homo sapiens_hsa053320.53814764
75African trypanosomiasis_Homo sapiens_hsa051430.52546321
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.52346892
77Autoimmune thyroid disease_Homo sapiens_hsa053200.52078335
78Salmonella infection_Homo sapiens_hsa051320.50089265
79Regulation of autophagy_Homo sapiens_hsa041400.49591961
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48624609
81Glutamatergic synapse_Homo sapiens_hsa047240.47137621
82Circadian entrainment_Homo sapiens_hsa047130.46802526
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46277937
84GABAergic synapse_Homo sapiens_hsa047270.45857380
85Pentose phosphate pathway_Homo sapiens_hsa000300.45294906
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44477615
87Olfactory transduction_Homo sapiens_hsa047400.44390160
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44300813
89Sulfur relay system_Homo sapiens_hsa041220.43548954
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41987896
91Arginine biosynthesis_Homo sapiens_hsa002200.39411223
92Amphetamine addiction_Homo sapiens_hsa050310.37280196
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36770664
94Dopaminergic synapse_Homo sapiens_hsa047280.36582242
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.36316520
96Hepatitis C_Homo sapiens_hsa051600.34958775
97Rheumatoid arthritis_Homo sapiens_hsa053230.34741606
98Type II diabetes mellitus_Homo sapiens_hsa049300.33483139
99Butanoate metabolism_Homo sapiens_hsa006500.32458120
100Salivary secretion_Homo sapiens_hsa049700.32219766
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32144314
102Dorso-ventral axis formation_Homo sapiens_hsa043200.31668988
103Fatty acid elongation_Homo sapiens_hsa000620.30619742
104Calcium signaling pathway_Homo sapiens_hsa040200.30138793
105Basal transcription factors_Homo sapiens_hsa030220.29717243
106Metabolic pathways_Homo sapiens_hsa011000.29487365
107Steroid biosynthesis_Homo sapiens_hsa001000.28014385
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27942743
109Gastric acid secretion_Homo sapiens_hsa049710.27175800
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26880599
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26880092
112Hematopoietic cell lineage_Homo sapiens_hsa046400.25992675
113beta-Alanine metabolism_Homo sapiens_hsa004100.25850179
114Adherens junction_Homo sapiens_hsa045200.24126238
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22831195
116Pyruvate metabolism_Homo sapiens_hsa006200.22101877
117Influenza A_Homo sapiens_hsa051640.21432772
118Carbon metabolism_Homo sapiens_hsa012000.19823946
119Vibrio cholerae infection_Homo sapiens_hsa051100.19669324
120Selenocompound metabolism_Homo sapiens_hsa004500.19456823
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18713536
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17835823
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17042020
124Pertussis_Homo sapiens_hsa051330.16012113
125Legionellosis_Homo sapiens_hsa051340.15529134
126Insulin secretion_Homo sapiens_hsa049110.14254745
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13806078
128N-Glycan biosynthesis_Homo sapiens_hsa005100.13327122
129TNF signaling pathway_Homo sapiens_hsa046680.11922492
130Thyroid cancer_Homo sapiens_hsa052160.10981802
131Other glycan degradation_Homo sapiens_hsa005110.10355436
132Alzheimers disease_Homo sapiens_hsa050100.09946353
133Bladder cancer_Homo sapiens_hsa052190.09486115
134Inositol phosphate metabolism_Homo sapiens_hsa005620.08924551
135Renin secretion_Homo sapiens_hsa049240.07304504
136GnRH signaling pathway_Homo sapiens_hsa049120.06928239
137Peroxisome_Homo sapiens_hsa041460.06236587
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05946012
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.05817348
140Tuberculosis_Homo sapiens_hsa051520.05350289

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