TMEM238

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.58506497
2proline biosynthetic process (GO:0006561)6.50576911
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)6.30650412
4viral transcription (GO:0019083)5.94411391
5translational termination (GO:0006415)5.72806810
6ribosomal small subunit assembly (GO:0000028)5.56507247
7proline metabolic process (GO:0006560)5.25895906
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.13033276
9translational elongation (GO:0006414)5.06627637
10protein targeting to ER (GO:0045047)5.00271658
11cotranslational protein targeting to membrane (GO:0006613)4.97900185
12desmosome organization (GO:0002934)4.76307868
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.72914381
14protein localization to endoplasmic reticulum (GO:0070972)4.72590051
15ribosomal small subunit biogenesis (GO:0042274)4.68936440
16pteridine-containing compound biosynthetic process (GO:0042559)4.50703031
17viral life cycle (GO:0019058)4.48726571
18prostaglandin biosynthetic process (GO:0001516)4.47541257
19prostanoid biosynthetic process (GO:0046457)4.47541257
20translational initiation (GO:0006413)4.42721740
21folic acid-containing compound biosynthetic process (GO:0009396)4.38868247
22ncRNA 3-end processing (GO:0043628)4.38306342
23telomere maintenance via semi-conservative replication (GO:0032201)4.36278311
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.29998388
25ribosomal large subunit biogenesis (GO:0042273)4.29678570
26regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26428006
27cellular protein complex disassembly (GO:0043624)4.25524014
28transcription from mitochondrial promoter (GO:0006390)4.11634786
29positive regulation of Cdc42 GTPase activity (GO:0043089)4.03619480
30DNA strand elongation involved in DNA replication (GO:0006271)3.99341427
31maturation of SSU-rRNA (GO:0030490)3.96980036
32glucose catabolic process (GO:0006007)3.86790069
33modulation by virus of host process (GO:0019054)3.85862401
34DNA strand elongation (GO:0022616)3.82428367
35positive regulation of keratinocyte differentiation (GO:0045618)3.74587017
36formation of translation preinitiation complex (GO:0001731)3.71139027
37protein complex disassembly (GO:0043241)3.67066161
38intestinal cholesterol absorption (GO:0030299)3.63380827
39negative regulation of cell size (GO:0045792)3.63200328
40sulfur amino acid catabolic process (GO:0000098)3.61023186
41activation of Rac GTPase activity (GO:0032863)3.58304429
42heme biosynthetic process (GO:0006783)3.53169892
43pseudouridine synthesis (GO:0001522)3.47210079
44UV protection (GO:0009650)3.42602084
45glucose 6-phosphate metabolic process (GO:0051156)3.41927792
46translation (GO:0006412)3.41406750
47telomere maintenance via recombination (GO:0000722)3.41211433
48macromolecular complex disassembly (GO:0032984)3.41027978
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37359368
50modulation by symbiont of host cellular process (GO:0044068)3.36181392
51apoptotic process involved in morphogenesis (GO:0060561)3.35613351
52endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.35364028
53mitochondrial fusion (GO:0008053)3.33402537
54ribonucleoprotein complex biogenesis (GO:0022613)3.33342062
55glutamine family amino acid biosynthetic process (GO:0009084)3.33264424
56GDP-mannose metabolic process (GO:0019673)3.32058129
57cellular response to virus (GO:0098586)3.31464456
58lipoxygenase pathway (GO:0019372)3.31366660
59folic acid metabolic process (GO:0046655)3.30406000
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.28786004
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.28509410
62oxidative phosphorylation (GO:0006119)3.25847349
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23461464
64L-phenylalanine metabolic process (GO:0006558)3.23461464
65focal adhesion assembly (GO:0048041)3.21581816
66cell-substrate adherens junction assembly (GO:0007045)3.21581816
67positive regulation of epidermal cell differentiation (GO:0045606)3.21456014
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.20885571
69protein targeting to membrane (GO:0006612)3.20542526
70negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.20009896
71pentose-phosphate shunt (GO:0006098)3.16522043
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15785153
73glycine metabolic process (GO:0006544)3.15604849
74negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.14376491
75regulation of translational elongation (GO:0006448)3.11950720
76mRNA catabolic process (GO:0006402)3.11561655
77prostanoid metabolic process (GO:0006692)3.10515975
78prostaglandin metabolic process (GO:0006693)3.10515975
79regulation of water loss via skin (GO:0033561)3.10303597
80tetrahydrofolate metabolic process (GO:0046653)3.06418844
81urea cycle (GO:0000050)3.06251138
82telomere maintenance via telomere lengthening (GO:0010833)3.03548173
83mitochondrial RNA metabolic process (GO:0000959)3.02062261
84pentose metabolic process (GO:0019321)3.01745527
85amyloid precursor protein catabolic process (GO:0042987)3.00963005
86replication fork processing (GO:0031297)3.00882975
87serine family amino acid biosynthetic process (GO:0009070)3.00060643
88nucleobase-containing small molecule interconversion (GO:0015949)2.99441367
89mitotic recombination (GO:0006312)2.99088473
90base-excision repair, AP site formation (GO:0006285)2.98358576
91RNA catabolic process (GO:0006401)2.98353873
92cysteine metabolic process (GO:0006534)2.96790234
93deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96535159
94positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.96155735
95pteridine-containing compound metabolic process (GO:0042558)2.95501290
96regulation of fatty acid beta-oxidation (GO:0031998)2.94172251
97heme metabolic process (GO:0042168)2.94107366
98mitochondrial DNA metabolic process (GO:0032042)2.94004331
99hydrogen peroxide catabolic process (GO:0042744)2.93923207
100T cell apoptotic process (GO:0070231)2.93652202
101negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.93193977
102rRNA processing (GO:0006364)2.92474598
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90491862
104regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.88854004
105nucleotide salvage (GO:0043173)2.87088713
106glutathione biosynthetic process (GO:0006750)2.86963357
107response to food (GO:0032094)2.86007710
108protein insertion into membrane (GO:0051205)2.84005425
109purine deoxyribonucleotide catabolic process (GO:0009155)2.83991982
110rRNA metabolic process (GO:0016072)2.82099857
111nucleoside diphosphate biosynthetic process (GO:0009133)2.80028095
112mitotic G1 DNA damage checkpoint (GO:0031571)2.79751184
113adherens junction assembly (GO:0034333)2.77134402
114nucleoside salvage (GO:0043174)2.76169566
115regulation of respiratory burst (GO:0060263)2.76005374
116urea metabolic process (GO:0019627)2.75910672
117proteasome assembly (GO:0043248)2.75503196
118positive regulation of histone deacetylation (GO:0031065)2.75181907
119protein retention in ER lumen (GO:0006621)2.74296018
120post-embryonic morphogenesis (GO:0009886)2.74235151
121mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.73546933
122pyrimidine nucleotide catabolic process (GO:0006244)2.73162687
123release of cytochrome c from mitochondria (GO:0001836)2.72807893
124serine family amino acid metabolic process (GO:0009069)2.69643985
125negative regulation of RNA splicing (GO:0033119)2.69442926
126cellular component biogenesis (GO:0044085)2.69392633
127cyclooxygenase pathway (GO:0019371)2.69130751
128maternal placenta development (GO:0001893)2.69002662
129one-carbon metabolic process (GO:0006730)2.68400798
130NADH metabolic process (GO:0006734)2.67788055
131NADPH regeneration (GO:0006740)2.67741650
132guanosine-containing compound biosynthetic process (GO:1901070)2.67371278
133pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.66705684
134regulation of viral release from host cell (GO:1902186)2.65945618
135nitric oxide biosynthetic process (GO:0006809)2.64518067
136calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.64444856
137positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64426426
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64280856
139viral mRNA export from host cell nucleus (GO:0046784)2.63990525
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63601709
141protein autoprocessing (GO:0016540)2.63480024
142DNA replication initiation (GO:0006270)2.63167551
143embryonic process involved in female pregnancy (GO:0060136)2.62335071
144folic acid-containing compound metabolic process (GO:0006760)2.61502897
145purine ribonucleoside diphosphate metabolic process (GO:0009179)2.61346447
146purine nucleoside diphosphate metabolic process (GO:0009135)2.61346447
147negative regulation of viral release from host cell (GO:1902187)2.60818960
148negative regulation of cell cycle arrest (GO:0071157)2.60437141
149lymphocyte apoptotic process (GO:0070227)2.60211022
150regulation of cholesterol biosynthetic process (GO:0045540)2.60012097
151NADP metabolic process (GO:0006739)2.59821205
152modulation by virus of host morphology or physiology (GO:0019048)2.59711047
153establishment of skin barrier (GO:0061436)2.59635906
154receptor catabolic process (GO:0032801)2.58170484
155positive regulation of protein targeting to membrane (GO:0090314)2.57907188
156L-phenylalanine catabolic process (GO:0006559)2.57717918
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57717918
158DNA unwinding involved in DNA replication (GO:0006268)2.57494859
159NIK/NF-kappaB signaling (GO:0038061)2.57164795
160pantothenate metabolic process (GO:0015939)2.55821244
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55237968
162mitotic G1/S transition checkpoint (GO:0044819)2.55068007
163oxidative demethylation (GO:0070989)2.53111150
164porphyrin-containing compound biosynthetic process (GO:0006779)2.52951622
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52903149
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.52903149
167pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.52065755
168dosage compensation (GO:0007549)2.52025093
169regulation of translational fidelity (GO:0006450)2.51838585
170nucleobase biosynthetic process (GO:0046112)2.49937476
171ribosome biogenesis (GO:0042254)2.48857892
172base-excision repair (GO:0006284)2.48066181
173negative regulation of fatty acid biosynthetic process (GO:0045717)2.46084158
174negative regulation of mRNA processing (GO:0050686)2.41826088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.62804709
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02940557
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96145701
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87231909
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71793069
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54008527
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39133582
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.21579915
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19240708
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.18862691
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.17162745
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.17093709
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15982545
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14842829
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13204979
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12816882
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.10181658
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.09294201
19VDR_21846776_ChIP-Seq_THP-1_Human2.01142630
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00940234
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99051670
22XRN2_22483619_ChIP-Seq_HELA_Human1.97835697
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.95450742
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93038493
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92262615
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91959536
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91427811
28DCP1A_22483619_ChIP-Seq_HELA_Human1.91081299
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88677982
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.86834817
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85166094
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77454522
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73883397
34P68_20966046_ChIP-Seq_HELA_Human1.72869607
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72464807
36MYC_22102868_ChIP-Seq_BL_Human1.70607114
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61127489
38GABP_19822575_ChIP-Seq_HepG2_Human1.60955780
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60099355
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57390669
41KDM2B_26808549_Chip-Seq_DND41_Human1.57345560
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56820715
43TCF7_22412390_ChIP-Seq_EML_Mouse1.56567449
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56046308
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.55103181
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54946131
47VDR_23849224_ChIP-Seq_CD4+_Human1.54491049
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52182632
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51390382
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50599751
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.49234000
52SMC4_20622854_ChIP-Seq_HELA_Human1.48310815
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48266955
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48237635
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47523671
56TTF2_22483619_ChIP-Seq_HELA_Human1.47362537
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47099483
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.45758963
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45745574
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44339443
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43344483
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42170220
63CREB1_26743006_Chip-Seq_LNCaP_Human1.39841295
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38553629
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37545967
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.36543565
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36230920
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35573791
69BCOR_27268052_Chip-Seq_Bcells_Human1.34602519
70LXR_22292898_ChIP-Seq_THP-1_Human1.34354512
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.33338377
72FOXP3_21729870_ChIP-Seq_TREG_Human1.32629859
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32119581
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31438811
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31070329
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29306779
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.29213343
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27785059
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27698962
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27137895
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.26583784
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26290206
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24964777
84BCL6_27268052_Chip-Seq_Bcells_Human1.24451117
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24343108
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24261146
87MAF_26560356_Chip-Seq_TH1_Human1.24260543
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23869994
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23803943
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.23245216
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23243473
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22112984
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.20502248
94ZNF263_19887448_ChIP-Seq_K562_Human1.19691118
95CTCF_21964334_Chip-Seq_Bcells_Human1.19496195
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.19425230
97KDM5A_27292631_Chip-Seq_BREAST_Human1.19394243
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18944664
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18530326
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18159258
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17056674
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.16832401
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15959188
104UTX_26944678_Chip-Seq_JUKART_Human1.15481889
105AR_21909140_ChIP-Seq_LNCAP_Human1.14128748
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13905385
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13611448
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.10894103
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09614008
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09264706
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09156352
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09155130
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08432301
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08072324
115GATA6_25053715_ChIP-Seq_YYC3_Human1.07663343
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07109481
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05974903
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05732165
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.05526530
120PHF8_20622854_ChIP-Seq_HELA_Human1.05431142
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04533327
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04111513
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03573716
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03040978
125KDM2B_26808549_Chip-Seq_K562_Human1.02528259
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02489703
127TP63_22573176_ChIP-Seq_HFKS_Human1.02372911
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02336457
129RACK7_27058665_Chip-Seq_MCF-7_Human1.02275639
130RARB_24833708_ChIP-Seq_LIVER_Mouse1.02158283
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.01657611
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00799524
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00576173
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99757523
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99569642
136MAF_26560356_Chip-Seq_TH2_Human0.98432279
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98404037
138MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98376645
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97062586
140ATF3_27146783_Chip-Seq_COLON_Human0.96666280
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94171669
142VDR_24763502_ChIP-Seq_THP-1_Human0.93800187
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92455459
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92116654
145HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91624352
146CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91405080
147FOXP1_21924763_ChIP-Seq_HESCs_Human0.90649834
148TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90467823
149CTCF_26484167_Chip-Seq_Bcells_Mouse0.90287064
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90047161
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89685104
152TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89532629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.87040041
2MP0002139_abnormal_hepatobiliary_system3.78750975
3MP0005360_urolithiasis3.73607722
4MP0005085_abnormal_gallbladder_physiolo3.50438642
5MP0003806_abnormal_nucleotide_metabolis3.36890552
6MP0005365_abnormal_bile_salt3.34790465
7MP0003693_abnormal_embryo_hatching2.77416273
8MP0005083_abnormal_biliary_tract2.73403374
9MP0000490_abnormal_crypts_of2.64774169
10MP0008057_abnormal_DNA_replication2.59949750
11MP0001666_abnormal_nutrient_absorption2.51138649
12MP0003656_abnormal_erythrocyte_physiolo2.48881120
13MP0009379_abnormal_foot_pigmentation2.47296423
14MP0003705_abnormal_hypodermis_morpholog2.37215313
15MP0004957_abnormal_blastocyst_morpholog2.31416578
16MP0005076_abnormal_cell_differentiation2.23641171
17MP0004185_abnormal_adipocyte_glucose2.18787382
18MP0005397_hematopoietic_system_phenotyp2.05254566
19MP0001545_abnormal_hematopoietic_system2.05254566
20MP0005220_abnormal_exocrine_pancreas1.98953109
21MP0003123_paternal_imprinting1.95379022
22MP0004858_abnormal_nervous_system1.94183510
23MP0010234_abnormal_vibrissa_follicle1.88677426
24MP0008875_abnormal_xenobiotic_pharmacok1.82809342
25MP0010094_abnormal_chromosome_stability1.79404557
26MP0002132_abnormal_respiratory_system1.76931542
27MP0004947_skin_inflammation1.69631395
28MP0003186_abnormal_redox_activity1.66413007
29MP0010155_abnormal_intestine_physiology1.59779586
30MP0005666_abnormal_adipose_tissue1.59773117
31MP0001873_stomach_inflammation1.52528729
32MP0002089_abnormal_postnatal_growth/wei1.51164489
33MP0004264_abnormal_extraembryonic_tissu1.49805453
34MP0003111_abnormal_nucleus_morphology1.48516640
35MP0002396_abnormal_hematopoietic_system1.45926801
36MP0003868_abnormal_feces_composition1.45358666
37MP0001216_abnormal_epidermal_layer1.45121787
38MP0004381_abnormal_hair_follicle1.44113010
39MP0002796_impaired_skin_barrier1.43476314
40MP0001849_ear_inflammation1.43220186
41MP0001663_abnormal_digestive_system1.40323561
42MP0009278_abnormal_bone_marrow1.38578097
43MP0006036_abnormal_mitochondrial_physio1.36434642
44MP0004019_abnormal_vitamin_homeostasis1.36153920
45MP0001661_extended_life_span1.35284117
46MP0010352_gastrointestinal_tract_polyps1.35216953
47MP0005174_abnormal_tail_pigmentation1.35174734
48MP0009840_abnormal_foam_cell1.33184407
49MP0005319_abnormal_enzyme/_coenzyme1.32522502
50MP0003252_abnormal_bile_duct1.32278472
51MP0003763_abnormal_thymus_physiology1.31946541
52MP0002249_abnormal_larynx_morphology1.31740954
53MP0005332_abnormal_amino_acid1.31687089
54MP0005375_adipose_tissue_phenotype1.31389896
55MP0003866_abnormal_defecation1.29604731
56MP0010678_abnormal_skin_adnexa1.29105155
57MP0008004_abnormal_stomach_pH1.27184940
58MP0010030_abnormal_orbit_morphology1.25830948
59MP0005501_abnormal_skin_physiology1.24857456
60MP0009643_abnormal_urine_homeostasis1.23540314
61MP0003077_abnormal_cell_cycle1.22995796
62MP0008260_abnormal_autophagy1.22803407
63MP0002138_abnormal_hepatobiliary_system1.22182783
64MP0003191_abnormal_cellular_cholesterol1.21805751
65MP0000537_abnormal_urethra_morphology1.21199567
66MP0005670_abnormal_white_adipose1.19481323
67MP0000685_abnormal_immune_system1.19221157
68MP0010329_abnormal_lipoprotein_level1.19114269
69MP0003453_abnormal_keratinocyte_physiol1.18369513
70MP0000858_altered_metastatic_potential1.17666864
71MP0005381_digestive/alimentary_phenotyp1.17651599
72MP0000538_abnormal_urinary_bladder1.16239125
73MP0000609_abnormal_liver_physiology1.16114798
74MP0001764_abnormal_homeostasis1.15458821
75MP0000477_abnormal_intestine_morphology1.13099809
76MP0000470_abnormal_stomach_morphology1.12285118
77MP0009333_abnormal_splenocyte_physiolog1.11137988
78MP0004808_abnormal_hematopoietic_stem1.10125879
79MP0005636_abnormal_mineral_homeostasis1.10017278
80MP0000003_abnormal_adipose_tissue1.08072525
81MP0000383_abnormal_hair_follicle1.07058863
82MP0005075_abnormal_melanosome_morpholog1.05539597
83MP0002166_altered_tumor_susceptibility1.05490487
84MP0002019_abnormal_tumor_incidence1.05259230
85MP0000467_abnormal_esophagus_morphology1.03625771
86MP0005310_abnormal_salivary_gland1.03594111
87MP0008932_abnormal_embryonic_tissue1.03117728
88MP0003436_decreased_susceptibility_to1.02096535
89MP0001881_abnormal_mammary_gland1.01973228
90MP0001664_abnormal_digestion1.01969336
91MP0000377_abnormal_hair_follicle1.01849412
92MP0000566_synostosis0.99742868
93MP0003786_premature_aging0.98438247
94MP0006054_spinal_hemorrhage0.98427036
95MP0010771_integument_phenotype0.97518019
96MP0000598_abnormal_liver_morphology0.94482227
97MP0003724_increased_susceptibility_to0.94417180
98MP0000579_abnormal_nail_morphology0.91808342
99MP0000462_abnormal_digestive_system0.90742773
100MP0001944_abnormal_pancreas_morphology0.89934071
101MP0000689_abnormal_spleen_morphology0.89931552
102MP0003300_gastrointestinal_ulcer0.89409713
103MP0001765_abnormal_ion_homeostasis0.88496458
104MP0003718_maternal_effect0.88188539
105MP0000627_abnormal_mammary_gland0.87847037
106MP0004233_abnormal_muscle_weight0.87561031
107MP0004782_abnormal_surfactant_physiolog0.87113563
108MP0009053_abnormal_anal_canal0.86711013
109MP0003283_abnormal_digestive_organ0.86696531
110MP0005084_abnormal_gallbladder_morpholo0.86143824
111MP0002970_abnormal_white_adipose0.85234995
112MP0008995_early_reproductive_senescence0.84743381
113MP0000313_abnormal_cell_death0.83667222
114MP0005584_abnormal_enzyme/coenzyme_acti0.83625011
115MP0008872_abnormal_physiological_respon0.83362271
116MP0008058_abnormal_DNA_repair0.83003911
117MP0000750_abnormal_muscle_regeneration0.82976710
118MP0002722_abnormal_immune_system0.82226296
119MP0002060_abnormal_skin_morphology0.82035812
120MP0000350_abnormal_cell_proliferation0.80690254
121MP0004510_myositis0.80595214
122MP0003075_altered_response_to0.80386159
123MP0001853_heart_inflammation0.79733212
124MP0002009_preneoplasia0.79041963
125MP0002405_respiratory_system_inflammati0.78967661
126MP0000678_abnormal_parathyroid_gland0.78878591
127MP0005464_abnormal_platelet_physiology0.78544033
128MP0002118_abnormal_lipid_homeostasis0.78019262
129MP0008469_abnormal_protein_level0.77956890
130MP0000613_abnormal_salivary_gland0.77687682
131MP0001348_abnormal_lacrimal_gland0.77125034
132MP0000015_abnormal_ear_pigmentation0.77124385
133MP0002693_abnormal_pancreas_physiology0.76268796
134MP0005266_abnormal_metabolism0.76098747
135MP0002098_abnormal_vibrissa_morphology0.75604103
136MP0004147_increased_porphyrin_level0.75505259
137MP0002086_abnormal_extraembryonic_tissu0.74141816
138MP0005058_abnormal_lysosome_morphology0.73596601
139MP0000367_abnormal_coat/_hair0.72734298
140MP0001730_embryonic_growth_arrest0.72648425
141MP0003638_abnormal_response/metabolism_0.72363630
142MP0002398_abnormal_bone_marrow0.72126416
143MP0009931_abnormal_skin_appearance0.71119523
144MP0003119_abnormal_digestive_system0.69512240
145MP0001845_abnormal_inflammatory_respons0.69079503
146MP0000703_abnormal_thymus_morphology0.68546314
147MP0005025_abnormal_response_to0.68229655
148MP0003183_abnormal_peptide_metabolism0.66989600

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.47507242
2Abnormality of cells of the erythroid lineage (HP:0012130)5.43561002
3Abnormal hemoglobin (HP:0011902)4.46792867
4Reticulocytopenia (HP:0001896)4.35016763
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98453983
6Pallor (HP:0000980)3.72352017
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.71888762
8Macrocytic anemia (HP:0001972)3.70076168
9Distal lower limb muscle weakness (HP:0009053)3.69354949
10Pili torti (HP:0003777)3.60307300
11Pustule (HP:0200039)3.45346583
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.42708504
13Poikiloderma (HP:0001029)3.37254474
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21768300
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21768300
16Hypobetalipoproteinemia (HP:0003563)3.11485821
17Aplastic anemia (HP:0001915)3.11041625
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.09622232
19Septate vagina (HP:0001153)3.04915813
20Flat acetabular roof (HP:0003180)3.02690476
21Intrahepatic cholestasis (HP:0001406)2.97649197
22Abnormal hair laboratory examination (HP:0003328)2.94968183
23Testicular atrophy (HP:0000029)2.91532229
24Ragged-red muscle fibers (HP:0003200)2.90769947
25Oral leukoplakia (HP:0002745)2.89815759
26Hepatic necrosis (HP:0002605)2.88261184
27Exertional dyspnea (HP:0002875)2.79596182
28Spinal cord compression (HP:0002176)2.79501409
29Hypoglycemic coma (HP:0001325)2.77146999
30Increased intramyocellular lipid droplets (HP:0012240)2.73413519
31Growth hormone excess (HP:0000845)2.71108227
32Increased muscle lipid content (HP:0009058)2.70339232
33Abnormality of reticulocytes (HP:0004312)2.67929337
34Prolonged neonatal jaundice (HP:0006579)2.67537491
35Stridor (HP:0010307)2.65294410
36Micronodular cirrhosis (HP:0001413)2.62092859
37Thin bony cortex (HP:0002753)2.61097792
38Hyperparathyroidism (HP:0000843)2.61066146
39Bulbar palsy (HP:0001283)2.60482767
40Acanthocytosis (HP:0001927)2.58133039
41Hepatocellular necrosis (HP:0001404)2.58110605
42Achilles tendon contracture (HP:0001771)2.57234510
43Diaphragmatic weakness (HP:0009113)2.55362234
44Abdominal distention (HP:0003270)2.54087193
45Obstructive sleep apnea (HP:0002870)2.51931576
46Absent thumb (HP:0009777)2.51486240
47Acanthosis nigricans (HP:0000956)2.50691009
48Hyperammonemia (HP:0001987)2.47396353
49Ketoacidosis (HP:0001993)2.47138152
50Hyperacusis (HP:0010780)2.42281767
51Ketosis (HP:0001946)2.41330953
52Amelogenesis imperfecta (HP:0000705)2.40756488
53Thrombocytosis (HP:0001894)2.39198138
54Myopathic facies (HP:0002058)2.37755921
55Abnormality of the Achilles tendon (HP:0005109)2.37263748
56Nasal polyposis (HP:0100582)2.35224597
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.34051844
58Hypokinesia (HP:0002375)2.32718640
59J-shaped sella turcica (HP:0002680)2.30194824
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30190587
61Increased serum lactate (HP:0002151)2.29446856
62Abnormality of small intestinal villus morphology (HP:0011472)2.29235956
63Villous atrophy (HP:0011473)2.29235956
64Hemorrhage of the eye (HP:0011885)2.28070506
65Urinary glycosaminoglycan excretion (HP:0003541)2.27182834
66Mucopolysacchariduria (HP:0008155)2.27182834
67Abnormality of pyrimidine metabolism (HP:0004353)2.25806491
68Hyperbilirubinemia (HP:0002904)2.24896577
69Generalized aminoaciduria (HP:0002909)2.22071978
70Colon cancer (HP:0003003)2.21935373
71Mitochondrial inheritance (HP:0001427)2.21424133
72Lipid accumulation in hepatocytes (HP:0006561)2.20306784
73Distal upper limb amyotrophy (HP:0007149)2.19802988
74Upper limb amyotrophy (HP:0009129)2.19802988
75Easy fatigability (HP:0003388)2.19795311
76Abnormality of the distal phalanges of the toes (HP:0010182)2.16270940
77Dicarboxylic aciduria (HP:0003215)2.16077272
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16077272
79Poikilocytosis (HP:0004447)2.15461241
80Ileus (HP:0002595)2.15416472
81Increased serum ferritin (HP:0003281)2.14800300
82Broad face (HP:0000283)2.12942878
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12918155
84Colitis (HP:0002583)2.12006943
85Hypotrichosis (HP:0001006)2.11809730
86Abnormal urine phosphate concentration (HP:0012599)2.10721437
87Prolonged bleeding time (HP:0003010)2.10578802
88Late onset (HP:0003584)2.10386107
89Erythema (HP:0010783)2.09397176
90Reduced antithrombin III activity (HP:0001976)2.07855992
91Fat malabsorption (HP:0002630)2.07492291
92Progressive muscle weakness (HP:0003323)2.07066337
93Respiratory difficulties (HP:0002880)2.05441870
94Increased hepatocellular lipid droplets (HP:0006565)2.05287651
95Rough bone trabeculation (HP:0100670)2.04395500
96Lethargy (HP:0001254)2.04146672
97Renal Fanconi syndrome (HP:0001994)2.03566913
98Acute encephalopathy (HP:0006846)2.03527032
99Abnormality of T cell physiology (HP:0011840)2.03135793
100Glycosuria (HP:0003076)2.02754116
101Abnormality of urine glucose concentration (HP:0011016)2.02754116
102Petechiae (HP:0000967)2.02753467
103Microcytic anemia (HP:0001935)2.02729451
104Polycythemia (HP:0001901)2.02374372
105Premature graying of hair (HP:0002216)2.01885808
106Multiple enchondromatosis (HP:0005701)2.00457735
107Microretrognathia (HP:0000308)2.00372545
108Opisthotonus (HP:0002179)1.99299733
109Concave nail (HP:0001598)1.99240545
110Seborrheic dermatitis (HP:0001051)1.98947871
111Increased cerebral lipofuscin (HP:0011813)1.98689870
11211 pairs of ribs (HP:0000878)1.98480744
113Abnormality of polysaccharide metabolism (HP:0011012)1.98081887
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98081887
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98081887
116Ventricular fibrillation (HP:0001663)1.97760469
117Sparse lateral eyebrow (HP:0005338)1.97653228
118Dry hair (HP:0011359)1.97344219
119Trismus (HP:0000211)1.97035468
120Type I transferrin isoform profile (HP:0003642)1.96920633
121Increased CSF lactate (HP:0002490)1.95886932
122Hyperphosphaturia (HP:0003109)1.95823371
123Basal cell carcinoma (HP:0002671)1.95365189
124Lactic acidosis (HP:0003128)1.94903382
125Xanthomatosis (HP:0000991)1.94006237
126Polygenic inheritance (HP:0010982)1.92236566
127Pancytopenia (HP:0001876)1.91619498
128Gastrointestinal inflammation (HP:0004386)1.91169416
129Redundant skin (HP:0001582)1.90831834
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90598694
131Dysostosis multiplex (HP:0000943)1.89589089
132Germ cell neoplasia (HP:0100728)1.89530607
133Ridged nail (HP:0001807)1.89101056
134Abnormal trabecular bone morphology (HP:0100671)1.88607536
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88324992
136Delayed CNS myelination (HP:0002188)1.87686933
137Long palpebral fissure (HP:0000637)1.87625139
138Hypochromic anemia (HP:0001931)1.87460754
139Abnormality of transition element cation homeostasis (HP:0011030)1.87313764
140Vertebral compression fractures (HP:0002953)1.87270624
141Abnormality of iron homeostasis (HP:0011031)1.87006711
142Hyperglycinemia (HP:0002154)1.86052643
143Abnormality of the nasal mucosa (HP:0000433)1.85024244
144Axonal loss (HP:0003447)1.84461137
145IgM deficiency (HP:0002850)1.83873884
146Nail dystrophy (HP:0008404)1.80429680
147Eczematoid dermatitis (HP:0000976)1.79778859
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79671189
149Abnormal mitochondria in muscle tissue (HP:0008316)1.79651679
150Hypolipoproteinemia (HP:0010981)1.79467638
151Hyperglycinuria (HP:0003108)1.77586321
152Cerebral edema (HP:0002181)1.77161951
153Sparse eyelashes (HP:0000653)1.76696777
154Hyperactive renin-angiotensin system (HP:0000841)1.76616053
155Malnutrition (HP:0004395)1.76309170
156Prolonged partial thromboplastin time (HP:0003645)1.75859038
157Joint stiffness (HP:0001387)1.75534573
158Menorrhagia (HP:0000132)1.73998857
159Reticulocytosis (HP:0001923)1.73942660
160Progressive hearing impairment (HP:0001730)1.69193333
161Alkalosis (HP:0001948)1.69062872
162Abnormality of carpal bone ossification (HP:0006257)1.67782529
163Hypophosphatemia (HP:0002148)1.67574250
164Hyponatremia (HP:0002902)1.67265573
165Cardiomegaly (HP:0001640)1.66667642
166Unilateral renal agenesis (HP:0000122)1.65074159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.26408868
2SIK13.92260323
3MAPK153.64275767
4ARAF3.51614666
5MAP3K113.14222694
6MUSK3.08932976
7PIM23.04597357
8BCKDK2.99405526
9SMG12.84642128
10MST1R2.47776518
11EIF2AK12.46221995
12STK162.31929470
13TLK12.29685324
14VRK22.25266221
15ERN12.23549106
16DDR22.11727344
17MATK2.07075207
18ACVR1B1.90174335
19ICK1.87150871
20WEE11.86932737
21FLT31.83158359
22BRAF1.76852043
23ILK1.75911400
24RPS6KB21.75706947
25PRPF4B1.74551610
26MAP3K61.73683499
27CDK71.65447797
28MAP2K21.63631699
29MAP4K11.63331665
30CDC71.61718639
31SCYL21.56609671
32DYRK31.49094329
33TESK11.40967798
34DYRK1B1.36714500
35RPS6KA41.36318847
36VRK11.32603988
37CDK191.30203168
38IRAK21.29492162
39DAPK11.29147698
40NME11.28253722
41MAP3K101.26492366
42MAPK111.25544598
43PTK61.24515649
44TAOK31.22778220
45BUB11.19897562
46IRAK41.18375598
47KDR1.17718513
48CSK1.16488843
49TESK21.14841540
50PRKD31.08222776
51PIM11.06413952
52PDPK11.05585653
53PINK11.04896750
54PRKG20.99182798
55LMTK20.95849307
56EPHA20.93090069
57PLK10.93028659
58NEK20.92206407
59AURKB0.90787647
60MAPKAPK30.88988949
61PKN20.88082551
62MAP2K30.88059844
63CDK80.87452292
64LRRK20.87322636
65TYK20.87007002
66RIPK10.85686724
67TRIB30.83387771
68MAP3K80.82315930
69CDK60.81629724
70PRKD20.81065740
71BLK0.80929140
72MAP3K30.80460706
73HIPK20.76274966
74STK100.75864905
75MAP2K60.74849768
76TBK10.74740554
77AURKA0.73147128
78MAP3K10.72947858
79BMX0.71403691
80PASK0.70816812
81IRAK30.70585734
82TAOK20.69989890
83RPS6KA20.69709818
84CHEK20.69202300
85ATR0.68420830
86RPS6KL10.67823304
87RPS6KC10.67823304
88ABL20.66887591
89CSNK2A10.66844075
90CDK120.66657958
91EIF2AK30.66287182
92PAK40.65919835
93BTK0.65483373
94EEF2K0.64172499
95RPS6KA60.63931778
96YES10.63294515
97FRK0.63185220
98BRSK20.63013437
99TAOK10.62515698
100SIK30.59652020
101CSNK2A20.59443672
102FGR0.58639752
103MELK0.58551961
104GRK60.58406891
105MTOR0.57750563
106ZAP700.57603459
107IKBKB0.56817154
108CDK40.56769956
109RAF10.55355281
110LYN0.55174359
111TEC0.53574731
112KIT0.52922755
113UHMK10.52650437
114CAMK2G0.52321583
115RPS6KA10.51559171
116FGFR40.51382555
117CHUK0.49914389
118IRAK10.47713568
119MET0.47039334
120PRKCI0.46224070
121TRPM70.45329838
122MAPK40.44760830
123GSK3A0.44301400
124PDGFRA0.43918240
125PIK3CG0.43507591
126PDK10.42778751
127PIK3CA0.41206820
128MAP2K10.40603816
129TNK20.38605286
130EPHB10.38508789
131PTK20.36085762
132RPS6KA50.33055704
133CDC42BPA0.32443332
134MAP3K20.31160035
135MAPKAPK20.31101947
136PRKD10.28038910
137BRSK10.27301887
138IKBKE0.26394755
139CDK90.25747666
140MARK20.25672215
141AKT20.24264485
142PRKCD0.23917928
143STK380.22295338
144RIPK40.21499473
145STK40.20715723
146GRK50.19374242

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38941640
2DNA replication_Homo sapiens_hsa030303.69778200
3Mismatch repair_Homo sapiens_hsa034303.46682988
4Folate biosynthesis_Homo sapiens_hsa007902.98933031
5Base excision repair_Homo sapiens_hsa034102.50919670
6One carbon pool by folate_Homo sapiens_hsa006702.40134436
7Sulfur relay system_Homo sapiens_hsa041222.33637674
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.12878767
9Vitamin B6 metabolism_Homo sapiens_hsa007502.07575422
10Homologous recombination_Homo sapiens_hsa034402.03016142
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99542022
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.93524144
13Acute myeloid leukemia_Homo sapiens_hsa052211.91204835
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88174390
15Pyrimidine metabolism_Homo sapiens_hsa002401.78112922
16Nucleotide excision repair_Homo sapiens_hsa034201.67798167
17Spliceosome_Homo sapiens_hsa030401.64359275
18Selenocompound metabolism_Homo sapiens_hsa004501.61871200
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.57197405
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55886184
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.51864348
22Chronic myeloid leukemia_Homo sapiens_hsa052201.50417856
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47943615
24RNA polymerase_Homo sapiens_hsa030201.44621855
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.43498949
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43490882
27Fat digestion and absorption_Homo sapiens_hsa049751.41102430
28Protein export_Homo sapiens_hsa030601.40111519
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39026961
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37931378
31Hepatitis C_Homo sapiens_hsa051601.35415983
32Non-small cell lung cancer_Homo sapiens_hsa052231.34930888
33Biosynthesis of amino acids_Homo sapiens_hsa012301.32163429
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30744359
35Proteasome_Homo sapiens_hsa030501.28844036
36VEGF signaling pathway_Homo sapiens_hsa043701.28556782
37Sulfur metabolism_Homo sapiens_hsa009201.27718121
38Arginine and proline metabolism_Homo sapiens_hsa003301.26913475
39Glutathione metabolism_Homo sapiens_hsa004801.25671142
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22926919
41Arachidonic acid metabolism_Homo sapiens_hsa005901.22330877
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21380531
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.21246889
44Fatty acid degradation_Homo sapiens_hsa000711.19045858
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17362921
46Parkinsons disease_Homo sapiens_hsa050121.16293221
47Pentose phosphate pathway_Homo sapiens_hsa000301.14540290
48Arginine biosynthesis_Homo sapiens_hsa002201.13417109
49Notch signaling pathway_Homo sapiens_hsa043301.12333365
50Tryptophan metabolism_Homo sapiens_hsa003801.10018777
51RNA transport_Homo sapiens_hsa030131.09087491
52Endometrial cancer_Homo sapiens_hsa052131.06596347
53Oxidative phosphorylation_Homo sapiens_hsa001901.06304072
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04783924
55Insulin signaling pathway_Homo sapiens_hsa049101.03884718
56Chemical carcinogenesis_Homo sapiens_hsa052041.01871597
57Fanconi anemia pathway_Homo sapiens_hsa034601.01665458
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00269386
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99888642
60Peroxisome_Homo sapiens_hsa041460.98542742
61p53 signaling pathway_Homo sapiens_hsa041150.97076106
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96262683
63Insulin resistance_Homo sapiens_hsa049310.95649159
64Apoptosis_Homo sapiens_hsa042100.95030076
65mTOR signaling pathway_Homo sapiens_hsa041500.94843759
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94823207
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94310990
68Caffeine metabolism_Homo sapiens_hsa002320.91725210
69Tyrosine metabolism_Homo sapiens_hsa003500.91347509
70Carbon metabolism_Homo sapiens_hsa012000.89570082
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89538615
72Fatty acid biosynthesis_Homo sapiens_hsa000610.83838374
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83649948
74beta-Alanine metabolism_Homo sapiens_hsa004100.82741852
75Fructose and mannose metabolism_Homo sapiens_hsa000510.82247649
76B cell receptor signaling pathway_Homo sapiens_hsa046620.82155311
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81608044
78Galactose metabolism_Homo sapiens_hsa000520.81603191
79Histidine metabolism_Homo sapiens_hsa003400.80675520
80Pancreatic cancer_Homo sapiens_hsa052120.77269927
81N-Glycan biosynthesis_Homo sapiens_hsa005100.76490165
82Fatty acid metabolism_Homo sapiens_hsa012120.76069690
83Bladder cancer_Homo sapiens_hsa052190.74346719
84AMPK signaling pathway_Homo sapiens_hsa041520.73630982
85Pyruvate metabolism_Homo sapiens_hsa006200.73430325
86ErbB signaling pathway_Homo sapiens_hsa040120.72096334
87Huntingtons disease_Homo sapiens_hsa050160.71576279
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71047149
89Propanoate metabolism_Homo sapiens_hsa006400.70587413
90Nitrogen metabolism_Homo sapiens_hsa009100.70055311
91Vibrio cholerae infection_Homo sapiens_hsa051100.69713408
92Starch and sucrose metabolism_Homo sapiens_hsa005000.68299804
93Metabolic pathways_Homo sapiens_hsa011000.67736830
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67217977
95Cell cycle_Homo sapiens_hsa041100.66009667
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62756032
97Retinol metabolism_Homo sapiens_hsa008300.62579257
98Butanoate metabolism_Homo sapiens_hsa006500.61872243
99Prion diseases_Homo sapiens_hsa050200.61244136
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59777725
101Bile secretion_Homo sapiens_hsa049760.59746873
102Alzheimers disease_Homo sapiens_hsa050100.56409301
103RNA degradation_Homo sapiens_hsa030180.56003134
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55586648
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55479670
106Renal cell carcinoma_Homo sapiens_hsa052110.54758793
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53847614
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53732944
109Purine metabolism_Homo sapiens_hsa002300.53693837
110Lysine degradation_Homo sapiens_hsa003100.53208461
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52812042
112ABC transporters_Homo sapiens_hsa020100.52449531
113TNF signaling pathway_Homo sapiens_hsa046680.52376449
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.52349850
115Lysosome_Homo sapiens_hsa041420.51613951
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50607086
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50269888
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49153637
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48530133
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47363268
121Other glycan degradation_Homo sapiens_hsa005110.47298927
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46747536
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.46307103
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46153616
125Linoleic acid metabolism_Homo sapiens_hsa005910.46009292
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.45968077
127Sphingolipid metabolism_Homo sapiens_hsa006000.45866042
128Fatty acid elongation_Homo sapiens_hsa000620.44698708
129Phenylalanine metabolism_Homo sapiens_hsa003600.43145104
130Legionellosis_Homo sapiens_hsa051340.42927532
131Thyroid cancer_Homo sapiens_hsa052160.42062347
132Protein digestion and absorption_Homo sapiens_hsa049740.41055032
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40973637
134Complement and coagulation cascades_Homo sapiens_hsa046100.39831806
135Vitamin digestion and absorption_Homo sapiens_hsa049770.39478563
136Prostate cancer_Homo sapiens_hsa052150.39068186
137Primary immunodeficiency_Homo sapiens_hsa053400.39038217
138Hepatitis B_Homo sapiens_hsa051610.38738323
139Influenza A_Homo sapiens_hsa051640.38701301
140Systemic lupus erythematosus_Homo sapiens_hsa053220.38455968
141T cell receptor signaling pathway_Homo sapiens_hsa046600.38243364
142Endocytosis_Homo sapiens_hsa041440.37016732
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36179422
144Viral carcinogenesis_Homo sapiens_hsa052030.35548275
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.35484965
146HTLV-I infection_Homo sapiens_hsa051660.35053791
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32011731
148Small cell lung cancer_Homo sapiens_hsa052220.31896832
149Renin-angiotensin system_Homo sapiens_hsa046140.31443301
150Epstein-Barr virus infection_Homo sapiens_hsa051690.31224030

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