TMEM239

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)8.35239432
2cell wall macromolecule metabolic process (GO:0044036)8.35239432
3sperm motility (GO:0030317)8.26585669
4polyketide metabolic process (GO:0030638)8.15567551
5doxorubicin metabolic process (GO:0044598)8.15567551
6daunorubicin metabolic process (GO:0044597)8.15567551
7acrosome reaction (GO:0007340)7.81828435
8epithelial cilium movement (GO:0003351)6.39450552
9fusion of sperm to egg plasma membrane (GO:0007342)6.27641112
10motile cilium assembly (GO:0044458)6.22219915
11acrosome assembly (GO:0001675)6.02151292
12sperm-egg recognition (GO:0035036)5.86035390
13multicellular organism reproduction (GO:0032504)5.85416379
14axonemal dynein complex assembly (GO:0070286)5.62755165
15spermatid development (GO:0007286)5.32424095
16response to pheromone (GO:0019236)5.31717183
17cell-cell recognition (GO:0009988)5.23572932
18cilium movement (GO:0003341)5.14601851
19binding of sperm to zona pellucida (GO:0007339)5.08003904
20aminoglycoside antibiotic metabolic process (GO:0030647)5.06495360
21sperm capacitation (GO:0048240)5.05730290
22reproduction (GO:0000003)5.04108440
23cellular ketone body metabolic process (GO:0046950)4.99783629
24plasma membrane fusion (GO:0045026)4.96356269
25microtubule depolymerization (GO:0007019)4.93711698
26behavioral response to nicotine (GO:0035095)4.88588501
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.76738822
28detection of molecule of bacterial origin (GO:0032490)4.73629192
29cilium or flagellum-dependent cell motility (GO:0001539)4.57395756
30ketone body metabolic process (GO:1902224)4.51788429
31protein polyglutamylation (GO:0018095)4.50158981
32regulation of cilium movement (GO:0003352)4.48549963
33sulfate transmembrane transport (GO:1902358)4.36289104
34organic cation transport (GO:0015695)4.30559237
35auditory receptor cell stereocilium organization (GO:0060088)4.26997589
36sulfate transport (GO:0008272)3.98435701
37spermatogenesis (GO:0007283)3.97572602
38male gamete generation (GO:0048232)3.95620639
39energy homeostasis (GO:0097009)3.92463615
40detection of light stimulus involved in visual perception (GO:0050908)3.86691973
41detection of light stimulus involved in sensory perception (GO:0050962)3.86691973
42single fertilization (GO:0007338)3.86548253
43piRNA metabolic process (GO:0034587)3.82776021
44positive regulation of cellular amide metabolic process (GO:0034250)3.81543291
45L-fucose catabolic process (GO:0042355)3.78905562
46fucose catabolic process (GO:0019317)3.78905562
47L-fucose metabolic process (GO:0042354)3.78905562
48male meiosis (GO:0007140)3.74666103
49regulation of activation of Janus kinase activity (GO:0010533)3.69055168
50gamete generation (GO:0007276)3.63626075
51calcium ion-dependent exocytosis (GO:0017156)3.63254618
52DNA methylation involved in gamete generation (GO:0043046)3.57327279
53positive regulation of CREB transcription factor activity (GO:0032793)3.56610759
54detection of external biotic stimulus (GO:0098581)3.52751309
55water-soluble vitamin biosynthetic process (GO:0042364)3.43419439
56regulation of microtubule-based movement (GO:0060632)3.40974634
57polyol transport (GO:0015791)3.33621659
58rRNA methylation (GO:0031167)3.31674115
59negative regulation of inclusion body assembly (GO:0090084)3.30392493
60opioid receptor signaling pathway (GO:0038003)3.29112297
61indolalkylamine metabolic process (GO:0006586)3.28900320
62axoneme assembly (GO:0035082)3.25824207
63cellular anion homeostasis (GO:0030002)3.23603060
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22850696
65nonmotile primary cilium assembly (GO:0035058)3.21501693
66establishment of protein localization to Golgi (GO:0072600)3.21060184
67tryptophan catabolic process (GO:0006569)3.20718999
68indole-containing compound catabolic process (GO:0042436)3.20718999
69indolalkylamine catabolic process (GO:0046218)3.20718999
70behavioral response to ethanol (GO:0048149)3.20019596
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19894848
72nephron epithelium morphogenesis (GO:0072088)3.15919647
73nephron tubule morphogenesis (GO:0072078)3.15919647
74centriole replication (GO:0007099)3.15582552
75sequestering of actin monomers (GO:0042989)3.14711516
76regulation of action potential (GO:0098900)3.14185764
77fertilization (GO:0009566)3.11083730
78platelet dense granule organization (GO:0060155)3.10466205
79centriole assembly (GO:0098534)3.10368455
80positive regulation of action potential (GO:0045760)3.09716481
81neuronal action potential (GO:0019228)3.09512476
82superoxide anion generation (GO:0042554)3.09151268
83germ cell development (GO:0007281)3.07825173
84inner ear receptor stereocilium organization (GO:0060122)3.05973110
85rRNA modification (GO:0000154)3.05588239
86detection of biotic stimulus (GO:0009595)3.04078135
87protein targeting to Golgi (GO:0000042)3.03326205
88seminiferous tubule development (GO:0072520)3.01874693
89negative regulation of telomere maintenance (GO:0032205)2.97603222
90pyrimidine nucleobase catabolic process (GO:0006208)2.97092367
91regulation of hexokinase activity (GO:1903299)2.96231372
92regulation of glucokinase activity (GO:0033131)2.96231372
93mannosylation (GO:0097502)2.95151053
94regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.94399067
95negative regulation of skeletal muscle tissue development (GO:0048642)2.94255638
96alanine transport (GO:0032328)2.94084907
97synaptonemal complex organization (GO:0070193)2.93207113
98primary amino compound metabolic process (GO:1901160)2.91650988
99cAMP catabolic process (GO:0006198)2.90470631
100protein complex biogenesis (GO:0070271)2.90380384
101kynurenine metabolic process (GO:0070189)2.90141358
102synaptonemal complex assembly (GO:0007130)2.89543833
103extracellular negative regulation of signal transduction (GO:1900116)2.88555276
104extracellular regulation of signal transduction (GO:1900115)2.88555276
105cellular process involved in reproduction in multicellular organism (GO:0022412)2.88468208
106male meiosis I (GO:0007141)2.88069042
107cilium organization (GO:0044782)2.86029662
108female gonad development (GO:0008585)2.85393407
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.84915165
110NADH dehydrogenase complex assembly (GO:0010257)2.84915165
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84915165
112drinking behavior (GO:0042756)2.83776012
113single strand break repair (GO:0000012)2.81701390
114positive regulation of protein sumoylation (GO:0033235)2.79630092
115positive regulation of mitochondrial fission (GO:0090141)2.79316039
116multicellular organismal reproductive process (GO:0048609)2.79114368
117protein K11-linked deubiquitination (GO:0035871)2.79045826
118somite rostral/caudal axis specification (GO:0032525)2.78317893
119protein-cofactor linkage (GO:0018065)2.78189805
120photoreceptor cell maintenance (GO:0045494)2.77450014
121positive regulation of icosanoid secretion (GO:0032305)2.74925637
122retrograde transport, vesicle recycling within Golgi (GO:0000301)2.74829182
123ubiquinone biosynthetic process (GO:0006744)2.74453638
124amine catabolic process (GO:0009310)2.73726708
125cellular biogenic amine catabolic process (GO:0042402)2.73726708
126cilium morphogenesis (GO:0060271)2.72776330
127cell recognition (GO:0008037)2.72392257
128gamma-aminobutyric acid transport (GO:0015812)2.71906028
129left/right pattern formation (GO:0060972)2.71191110
130negative regulation of mast cell activation (GO:0033004)2.70781031
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70603772
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70447290
133negative regulation of Rho protein signal transduction (GO:0035024)2.69364198
134trivalent inorganic anion homeostasis (GO:0072506)2.67824885
135phosphate ion homeostasis (GO:0055062)2.67824885
136mitochondrial respiratory chain complex assembly (GO:0033108)2.67800619
137prostate gland growth (GO:0060736)2.67431473
138protein localization to Golgi apparatus (GO:0034067)2.67128157
139DNA deamination (GO:0045006)2.66226799
140cyclic nucleotide catabolic process (GO:0009214)2.66120019
141regulation of inclusion body assembly (GO:0090083)2.64493714
142ubiquinone metabolic process (GO:0006743)2.63496034
143ventricular system development (GO:0021591)2.63399554
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.63179273
145mesenchymal cell differentiation involved in kidney development (GO:0072161)2.63179273
146synapsis (GO:0007129)2.62738297
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60001524
148synaptic transmission, cholinergic (GO:0007271)2.59842817
149dopamine transport (GO:0015872)2.59155558
150positive regulation of uterine smooth muscle contraction (GO:0070474)2.58861462
151regulation of neurotransmitter uptake (GO:0051580)2.58053149
152chromosome organization involved in meiosis (GO:0070192)2.57531318
153nucleobase catabolic process (GO:0046113)2.57342240
154ganglion development (GO:0061548)2.56582093
155estrogen biosynthetic process (GO:0006703)2.56571823
156reflex (GO:0060004)2.56500522
157microtubule polymerization or depolymerization (GO:0031109)2.55471310
158presynaptic membrane organization (GO:0097090)2.54776426
159regulation of spindle checkpoint (GO:0090231)2.54439508
160tryptophan metabolic process (GO:0006568)2.54277630
161spinal cord motor neuron differentiation (GO:0021522)2.54238781
162G-protein coupled receptor internalization (GO:0002031)2.53701612
163DNA double-strand break processing (GO:0000729)2.53537791
164presynaptic membrane assembly (GO:0097105)2.52327720
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52073729
166multicellular organismal development (GO:0007275)2.49526186
167cilium assembly (GO:0042384)2.48954383
168detection of other organism (GO:0098543)2.48719737
169replicative senescence (GO:0090399)2.47686873
170lateral ventricle development (GO:0021670)2.47168966
171regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44844310
172regulation of mitotic spindle checkpoint (GO:1903504)2.44844310
173startle response (GO:0001964)2.44738978
174cerebral cortex radially oriented cell migration (GO:0021799)2.42950548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01525369
2ZNF274_21170338_ChIP-Seq_K562_Hela3.77176972
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.49133207
4GBX2_23144817_ChIP-Seq_PC3_Human3.26841564
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23643260
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.91240744
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57314681
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.53357367
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44410496
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43189719
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26745907
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22931999
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15652130
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.13740790
15IGF1R_20145208_ChIP-Seq_DFB_Human2.06741084
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.97353297
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96300990
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94049369
19TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87916577
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86569100
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84596331
22VDR_22108803_ChIP-Seq_LS180_Human1.82956532
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79096730
24EWS_26573619_Chip-Seq_HEK293_Human1.77752538
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.77685568
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74764343
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.73971455
28P53_22387025_ChIP-Seq_ESCs_Mouse1.69242521
29E2F1_18555785_Chip-Seq_ESCs_Mouse1.68027153
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66072074
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63756377
32CMYC_18555785_Chip-Seq_ESCs_Mouse1.60916601
33RNF2_27304074_Chip-Seq_NSC_Mouse1.58142368
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.56216516
35P300_19829295_ChIP-Seq_ESCs_Human1.55419307
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53207402
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52644308
38OCT4_18555785_Chip-Seq_ESCs_Mouse1.51778279
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.50911476
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48502844
41P300_18555785_Chip-Seq_ESCs_Mouse1.48436168
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47283892
43SOX2_18555785_Chip-Seq_ESCs_Mouse1.47097608
44EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.47061102
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45965299
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.45472140
47IRF1_19129219_ChIP-ChIP_H3396_Human1.44790882
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44384567
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.44056386
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43377168
51PU1_27457419_Chip-Seq_LIVER_Mouse1.43099944
52NANOG_19829295_ChIP-Seq_ESCs_Human1.42444758
53SOX2_19829295_ChIP-Seq_ESCs_Human1.42444758
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.42441636
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42214889
56TAF15_26573619_Chip-Seq_HEK293_Human1.40623145
57KDM2B_26808549_Chip-Seq_REH_Human1.40483322
58ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40271513
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39974707
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39974707
61TP53_22573176_ChIP-Seq_HFKS_Human1.39751393
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39065301
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38790467
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.38570814
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.38004465
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.37724935
67BCAT_22108803_ChIP-Seq_LS180_Human1.36216962
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.36148490
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35888722
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35475965
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.34542066
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34535831
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.34436435
74SMAD4_21799915_ChIP-Seq_A2780_Human1.34362157
75ZFX_18555785_Chip-Seq_ESCs_Mouse1.33927737
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33696690
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32433554
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31138776
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30928993
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30902930
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.30902930
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30479944
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30295489
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29905205
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29748873
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.29605035
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.28608570
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.27369411
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.27261318
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26715007
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.25808587
92RUNX2_22187159_ChIP-Seq_PCA_Human1.25805266
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.25689356
94FUS_26573619_Chip-Seq_HEK293_Human1.24709922
95STAT1_17558387_ChIP-Seq_HELA_Human1.23956473
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22710126
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21450477
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21301454
99SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19549454
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19017546
101AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18860905
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18785569
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18571319
104NCOR_22424771_ChIP-Seq_293T_Human1.17811903
105GF1_26923725_Chip-Seq_HPCs_Mouse1.17699508
106TCF4_22108803_ChIP-Seq_LS180_Human1.17645282
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.17288487
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17232209
109MYC_19829295_ChIP-Seq_ESCs_Human1.16406369
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.16332135
111ER_23166858_ChIP-Seq_MCF-7_Human1.15310839
112AR_25329375_ChIP-Seq_VCAP_Human1.15246734
113DROSHA_22980978_ChIP-Seq_HELA_Human1.15180614
114ERA_21632823_ChIP-Seq_H3396_Human1.15173761
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13976218
116HOXB7_26014856_ChIP-Seq_BT474_Human1.13796659
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13346104
118ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13173578
119KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13167136
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.13123716
121JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12693383
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11907707
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10392095
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09402256
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08735971
126NANOG_20526341_ChIP-Seq_ESCs_Human1.08421929
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08128029
128TCF4_23295773_ChIP-Seq_U87_Human1.07660733
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07125614
130REST_18959480_ChIP-ChIP_MESCs_Mouse1.07051311
131EST1_17652178_ChIP-ChIP_JURKAT_Human1.06747025
132MYC_18940864_ChIP-ChIP_HL60_Human1.06541586
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04665388
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04362713
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04268145
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04133425
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03817556
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03454588
139CBP_20019798_ChIP-Seq_JUKART_Human1.03351199
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03351199
141AR_20517297_ChIP-Seq_VCAP_Human1.03033296
142TAF2_19829295_ChIP-Seq_ESCs_Human1.01422289
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00987339
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00938193
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00917087
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00842792
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00521729
148STAT3_23295773_ChIP-Seq_U87_Human1.00326442
149AR_21572438_ChIP-Seq_LNCaP_Human0.99401552
150GF1B_26923725_Chip-Seq_HPCs_Mouse0.99133233
151TP53_18474530_ChIP-ChIP_U2OS_Human0.98575475
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98326930
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.97368217
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.96924842
155ETV1_20927104_ChIP-Seq_GIST48_Human0.96139713
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96104833
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.95743848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.89607414
2MP0006292_abnormal_olfactory_placode4.30362423
3MP0003698_abnormal_male_reproductive2.98167275
4MP0000566_synostosis2.93148924
5MP0000015_abnormal_ear_pigmentation2.91505291
6MP0000678_abnormal_parathyroid_gland2.90558537
7MP0001188_hyperpigmentation2.76837384
8MP0005377_hearing/vestibular/ear_phenot2.74028242
9MP0003878_abnormal_ear_physiology2.74028242
10MP0005670_abnormal_white_adipose2.69042493
11MP0003880_abnormal_central_pattern2.68898708
12MP0005645_abnormal_hypothalamus_physiol2.61419016
13MP0000569_abnormal_digit_pigmentation2.61231360
14MP0009697_abnormal_copulation2.60179551
15MP0001929_abnormal_gametogenesis2.41546490
16MP0005171_absent_coat_pigmentation2.21076864
17MP0003941_abnormal_skin_development2.13085339
18MP0002132_abnormal_respiratory_system2.04128368
19MP0001529_abnormal_vocalization2.00202574
20MP0006072_abnormal_retinal_apoptosis1.99561704
21MP0001986_abnormal_taste_sensitivity1.99459228
22MP0008004_abnormal_stomach_pH1.99351043
23MP0002837_dystrophic_cardiac_calcinosis1.88622937
24MP0002277_abnormal_respiratory_mucosa1.86904654
25MP0003011_delayed_dark_adaptation1.84561544
26MP0004742_abnormal_vestibular_system1.82703463
27MP0005646_abnormal_pituitary_gland1.81894214
28MP0004885_abnormal_endolymph1.77690364
29MP0005253_abnormal_eye_physiology1.74878465
30MP0002638_abnormal_pupillary_reflex1.74521543
31MP0005084_abnormal_gallbladder_morpholo1.74172208
32MP0002822_catalepsy1.73139464
33MP0002210_abnormal_sex_determination1.69538853
34MP0001984_abnormal_olfaction1.65337998
35MP0008872_abnormal_physiological_respon1.63705932
36MP0004142_abnormal_muscle_tone1.62930615
37MP0003195_calcinosis1.61735751
38MP0005174_abnormal_tail_pigmentation1.61400587
39MP0003879_abnormal_hair_cell1.53236552
40MP0003787_abnormal_imprinting1.49921422
41MP0001502_abnormal_circadian_rhythm1.47146931
42MP0003136_yellow_coat_color1.46859499
43MP0004147_increased_porphyrin_level1.45593404
44MP0010386_abnormal_urinary_bladder1.45285820
45MP0002254_reproductive_system_inflammat1.45129694
46MP0008995_early_reproductive_senescence1.41246184
47MP0001905_abnormal_dopamine_level1.41061042
48MP0003718_maternal_effect1.40071232
49MP0002161_abnormal_fertility/fecundity1.40020245
50MP0005409_darkened_coat_color1.38897485
51MP0004133_heterotaxia1.38541925
52MP0004782_abnormal_surfactant_physiolog1.37403678
53MP0002653_abnormal_ependyma_morphology1.35939928
54MP0002733_abnormal_thermal_nociception1.35832572
55MP0008875_abnormal_xenobiotic_pharmacok1.35008598
56MP0001486_abnormal_startle_reflex1.34036970
57MP0002938_white_spotting1.33908073
58MP0001346_abnormal_lacrimal_gland1.32504108
59MP0001501_abnormal_sleep_pattern1.32068694
60MP0002735_abnormal_chemical_nociception1.31576925
61MP0005257_abnormal_intraocular_pressure1.29903919
62MP0001970_abnormal_pain_threshold1.27006181
63MP0008877_abnormal_DNA_methylation1.22763915
64MP0001919_abnormal_reproductive_system1.19876983
65MP0005423_abnormal_somatic_nervous1.19856879
66MP0002102_abnormal_ear_morphology1.18249643
67MP0002095_abnormal_skin_pigmentation1.18186251
68MP0001324_abnormal_eye_pigmentation1.17622800
69MP0000427_abnormal_hair_cycle1.16620497
70MP0005389_reproductive_system_phenotype1.16508422
71MP0002064_seizures1.15490598
72MP0002160_abnormal_reproductive_system1.14152443
73MP0002736_abnormal_nociception_after1.11666516
74MP0002067_abnormal_sensory_capabilities1.10661415
75MP0001145_abnormal_male_reproductive1.10387960
76MP0005367_renal/urinary_system_phenotyp1.08363589
77MP0000516_abnormal_urinary_system1.08363589
78MP0002557_abnormal_social/conspecific_i1.07692040
79MP0002138_abnormal_hepatobiliary_system1.07362746
80MP0003635_abnormal_synaptic_transmissio1.06277667
81MP0004043_abnormal_pH_regulation1.05707099
82MP0001485_abnormal_pinna_reflex1.05333562
83MP0002249_abnormal_larynx_morphology1.05020854
84MP0000653_abnormal_sex_gland1.04656871
85MP0005075_abnormal_melanosome_morpholog1.03076336
86MP0000681_abnormal_thyroid_gland1.01579933
87MP0005386_behavior/neurological_phenoty1.00878544
88MP0004924_abnormal_behavior1.00878544
89MP0002148_abnormal_hypersensitivity_rea0.99537790
90MP0002734_abnormal_mechanical_nocicepti0.99199358
91MP0005671_abnormal_response_to0.99061310
92MP0005248_abnormal_Harderian_gland0.96969795
93MP0002234_abnormal_pharynx_morphology0.95789200
94MP0005647_abnormal_sex_gland0.95451632
95MP0002063_abnormal_learning/memory/cond0.95442809
96MP0001835_abnormal_antigen_presentation0.93147914
97MP0005167_abnormal_blood-brain_barrier0.93115131
98MP0001348_abnormal_lacrimal_gland0.92569511
99MP0000026_abnormal_inner_ear0.92321162
100MP0003122_maternal_imprinting0.91888520
101MP0005332_abnormal_amino_acid0.91596625
102MP0001293_anophthalmia0.91374736
103MP0005195_abnormal_posterior_eye0.91300322
104MP0002075_abnormal_coat/hair_pigmentati0.91179914
105MP0002163_abnormal_gland_morphology0.90576175
106MP0000230_abnormal_systemic_arterial0.90441768
107MP0000372_irregular_coat_pigmentation0.90258018
108MP0002928_abnormal_bile_duct0.89483932
109MP0001186_pigmentation_phenotype0.88208473
110MP0002229_neurodegeneration0.88168509
111MP0003868_abnormal_feces_composition0.87975456
112MP0008775_abnormal_heart_ventricle0.87071123
113MP0002752_abnormal_somatic_nervous0.87022800
114MP0008789_abnormal_olfactory_epithelium0.86559021
115MP0005085_abnormal_gallbladder_physiolo0.85758417
116MP0001440_abnormal_grooming_behavior0.85509867
117MP0000049_abnormal_middle_ear0.84116692
118MP0004085_abnormal_heartbeat0.84006908
119MP0005379_endocrine/exocrine_gland_phen0.83949720
120MP0006276_abnormal_autonomic_nervous0.82737830
121MP0001963_abnormal_hearing_physiology0.82730023
122MP0001968_abnormal_touch/_nociception0.81502918
123MP0002177_abnormal_outer_ear0.81098122
124MP0009764_decreased_sensitivity_to0.79807626
125MP0009745_abnormal_behavioral_response0.79188801
126MP0002572_abnormal_emotion/affect_behav0.79077193
127MP0005387_immune_system_phenotype0.78709642
128MP0001790_abnormal_immune_system0.78709642
129MP0004134_abnormal_chest_morphology0.78629404
130MP0005551_abnormal_eye_electrophysiolog0.78400523
131MP0005394_taste/olfaction_phenotype0.78023817
132MP0005499_abnormal_olfactory_system0.78023817
133MP0000631_abnormal_neuroendocrine_gland0.77934893
134MP0002876_abnormal_thyroid_physiology0.76158983
135MP0003646_muscle_fatigue0.76084619
136MP0009046_muscle_twitch0.75476107
137MP0005310_abnormal_salivary_gland0.74053688
138MP0001119_abnormal_female_reproductive0.72695222
139MP0000371_diluted_coat_color0.70337743
140MP0008058_abnormal_DNA_repair0.69973786
141MP0003385_abnormal_body_wall0.67520488
142MP0009785_altered_susceptibility_to0.65734840
143MP0001664_abnormal_digestion0.63819749
144MP0009250_abnormal_appendicular_skeleto0.63577447
145MP0000613_abnormal_salivary_gland0.63218414
146MP0002272_abnormal_nervous_system0.62750368

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.68769474
2Absent/shortened dynein arms (HP:0200106)8.68769474
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.55445997
4Abnormal respiratory motile cilium morphology (HP:0005938)5.92535607
5Abnormal respiratory epithelium morphology (HP:0012253)5.92535607
6Abnormal respiratory motile cilium physiology (HP:0012261)5.59267926
7Abnormal ciliary motility (HP:0012262)5.11498847
8Congenital stationary night blindness (HP:0007642)4.17114184
9Rhinitis (HP:0012384)3.95304886
10Tubulointerstitial nephritis (HP:0001970)3.75902951
11Unilateral renal agenesis (HP:0000122)3.66665658
12Abnormal rod and cone electroretinograms (HP:0008323)3.62424556
13Attenuation of retinal blood vessels (HP:0007843)3.59952863
14Type II lissencephaly (HP:0007260)3.39868054
15Absent eyebrow (HP:0002223)3.29371792
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21586137
17Cheilitis (HP:0100825)3.16083056
18Nephronophthisis (HP:0000090)3.02481647
19Parakeratosis (HP:0001036)2.96765211
20Bony spicule pigmentary retinopathy (HP:0007737)2.95150300
21Osteomalacia (HP:0002749)2.87520785
22Chronic bronchitis (HP:0004469)2.85247824
23Infertility (HP:0000789)2.84758081
24Abnormality of macular pigmentation (HP:0008002)2.79343588
25Abnormality of the renal medulla (HP:0100957)2.76314885
26Decreased central vision (HP:0007663)2.75903750
27Optic neuritis (HP:0100653)2.74648294
28Retrobulbar optic neuritis (HP:0100654)2.74648294
29Pendular nystagmus (HP:0012043)2.70205568
30Septo-optic dysplasia (HP:0100842)2.68397392
31Hyperventilation (HP:0002883)2.67763571
32Dyschromatopsia (HP:0007641)2.66731681
33Renal dysplasia (HP:0000110)2.66054010
34Abnormal biliary tract physiology (HP:0012439)2.66011861
35Bile duct proliferation (HP:0001408)2.66011861
36Chromsome breakage (HP:0040012)2.65934646
37Optic nerve hypoplasia (HP:0000609)2.65355432
38Sclerocornea (HP:0000647)2.63377475
39Follicular hyperkeratosis (HP:0007502)2.62069728
40Alopecia of scalp (HP:0002293)2.59570128
41Gait imbalance (HP:0002141)2.57377591
42Hyperphosphatemia (HP:0002905)2.55946254
43Abnormality of midbrain morphology (HP:0002418)2.55547174
44Molar tooth sign on MRI (HP:0002419)2.55547174
45Chronic hepatic failure (HP:0100626)2.52574175
46Febrile seizures (HP:0002373)2.51259141
47Tetany (HP:0001281)2.46529967
48Congenital, generalized hypertrichosis (HP:0004540)2.45182145
49Lissencephaly (HP:0001339)2.42551695
50Polyuria (HP:0000103)2.41479137
51Type 2 muscle fiber atrophy (HP:0003554)2.40827454
52Tubulointerstitial abnormality (HP:0001969)2.40751080
53Congenital primary aphakia (HP:0007707)2.39665040
54True hermaphroditism (HP:0010459)2.38322105
55Abnormality of the renal cortex (HP:0011035)2.38008792
56Acute necrotizing encephalopathy (HP:0006965)2.36233204
57Ectopic kidney (HP:0000086)2.34269216
58Medial flaring of the eyebrow (HP:0010747)2.33348120
59Anencephaly (HP:0002323)2.32490129
60Acute encephalopathy (HP:0006846)2.30352396
61Bronchiectasis (HP:0002110)2.27682517
62Progressive macrocephaly (HP:0004481)2.23897380
63Occipital encephalocele (HP:0002085)2.21257449
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20742440
65Cerebellar dysplasia (HP:0007033)2.19835727
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19232217
67Congenital sensorineural hearing impairment (HP:0008527)2.17541617
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.16347345
69Cystic liver disease (HP:0006706)2.15888119
70Genital tract atresia (HP:0001827)2.15167655
71Abnormality of dental color (HP:0011073)2.14353105
72Abnormal urine output (HP:0012590)2.13648147
73Mitochondrial inheritance (HP:0001427)2.12938822
74Azoospermia (HP:0000027)2.12831152
75Abnormal drinking behavior (HP:0030082)2.11676896
76Polydipsia (HP:0001959)2.11676896
77Polyphagia (HP:0002591)2.11601263
78Abnormality of the renal collecting system (HP:0004742)2.11333235
79Renal cortical cysts (HP:0000803)2.10796181
80Absent eyelashes (HP:0000561)2.10752214
81Pancreatic cysts (HP:0001737)2.08827353
82Albinism (HP:0001022)2.07450621
83Recurrent sinusitis (HP:0011108)2.06894233
84Orchitis (HP:0100796)2.06321333
85Increased CSF lactate (HP:0002490)2.05922696
86Keratoconus (HP:0000563)2.05120504
87Increased corneal curvature (HP:0100692)2.05120504
88Pancreatic fibrosis (HP:0100732)2.03495235
89Vaginal atresia (HP:0000148)2.01876694
90Duplicated collecting system (HP:0000081)2.00750341
91Male pseudohermaphroditism (HP:0000037)2.00614527
92Progressive cerebellar ataxia (HP:0002073)1.99976106
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.99649804
94Large for gestational age (HP:0001520)1.99331515
95Optic disc pallor (HP:0000543)1.99062938
96Congenital hepatic fibrosis (HP:0002612)1.98014714
97Methylmalonic acidemia (HP:0002912)1.97566190
98Gaze-evoked nystagmus (HP:0000640)1.97214939
99Furrowed tongue (HP:0000221)1.95693532
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.95579212
101Hypoplasia of the fovea (HP:0007750)1.95579212
102Retinal dysplasia (HP:0007973)1.94503598
103Hyperglycinemia (HP:0002154)1.94156611
104Abnormal spermatogenesis (HP:0008669)1.93875777
105Colon cancer (HP:0003003)1.93199105
106Hepatic necrosis (HP:0002605)1.92396338
107Prostate neoplasm (HP:0100787)1.91691274
108Abnormality of molar (HP:0011077)1.91454636
109Abnormality of molar morphology (HP:0011070)1.91454636
110Pachygyria (HP:0001302)1.90212329
111Myositis (HP:0100614)1.90121311
112Postaxial foot polydactyly (HP:0001830)1.90060052
113Alveolar cell carcinoma (HP:0006519)1.90017339
114Generalized aminoaciduria (HP:0002909)1.89506343
115Bilateral sensorineural hearing impairment (HP:0008619)1.88223360
116Inability to walk (HP:0002540)1.88087329
117Clubbing of toes (HP:0100760)1.88016359
118Hepatocellular necrosis (HP:0001404)1.87796022
119Abnormal mitochondria in muscle tissue (HP:0008316)1.87778792
120Patchy hypopigmentation of hair (HP:0011365)1.87592818
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86899019
122Decreased circulating renin level (HP:0003351)1.85073273
123Stomach cancer (HP:0012126)1.84155326
124Glycosuria (HP:0003076)1.83405757
125Abnormality of urine glucose concentration (HP:0011016)1.83405757
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.83373326
127Easy fatigability (HP:0003388)1.82740251
128Abnormality of the labia minora (HP:0012880)1.82593553
129Oligohydramnios (HP:0001562)1.82506732
130Aplasia/hypoplasia of the uterus (HP:0008684)1.82465440
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.80624717
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79718711
133Abnormality of alanine metabolism (HP:0010916)1.79718711
134Hyperalaninemia (HP:0003348)1.79718711
135Aplasia/Hypoplasia of the lens (HP:0008063)1.79225856
136Methylmalonic aciduria (HP:0012120)1.78545964
137Nephrogenic diabetes insipidus (HP:0009806)1.76099128
138Focal motor seizures (HP:0011153)1.75798929
139Anophthalmia (HP:0000528)1.75187970
140White forelock (HP:0002211)1.75056006
141Postaxial hand polydactyly (HP:0001162)1.74941854
142Chorioretinal atrophy (HP:0000533)1.74264690
143Hypothermia (HP:0002045)1.73689703
144Abnormality of the dental root (HP:0006486)1.73440919
145Taurodontia (HP:0000679)1.73440919
146Abnormality of permanent molar morphology (HP:0011071)1.73440919
147Muscle fiber atrophy (HP:0100295)1.73018359
148Tubular atrophy (HP:0000092)1.72836828
149Abnormality of the fovea (HP:0000493)1.69840765
150Tachypnea (HP:0002789)1.69103635
151Chronic sinusitis (HP:0011109)1.68535819
152Abnormality of the preputium (HP:0100587)1.67777926
153Abolished electroretinogram (ERG) (HP:0000550)1.65638106
154Aganglionic megacolon (HP:0002251)1.64411130
155Aplasia/Hypoplasia of the macula (HP:0008059)1.62763756
156Hypergonadotropic hypogonadism (HP:0000815)1.62405637
157Abnormality of renal excretion (HP:0011036)1.60832222
158Severe visual impairment (HP:0001141)1.60123688
159Abnormality of the dental pulp (HP:0006479)1.59938002
160Meckel diverticulum (HP:0002245)1.59254130
161Bell-shaped thorax (HP:0001591)1.59058554
162Astigmatism (HP:0000483)1.58218952
163Recurrent corneal erosions (HP:0000495)1.57558140
164Abnormality of DNA repair (HP:0003254)1.57549312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26180853
2SIK35.00485913
3ZAK3.14685059
4MAP4K23.00828452
5CASK2.90001052
6TESK12.75134189
7SIK22.60128844
8ADRBK22.52080370
9PRKD32.44687977
10STK38L2.34147785
11PDK42.33667567
12PDK32.33667567
13TXK2.31249880
14WNK32.28820854
15PRPF4B2.15357526
16MAP3K142.14888562
17BMPR1B2.09518139
18INSRR2.02002131
19YES12.01995541
20MAP2K72.00679589
21PNCK1.94392721
22ICK1.90573150
23SGK21.66891823
24PINK11.66861638
25PLK21.66799970
26MAPK131.64573622
27PDK21.62483279
28TAOK31.61541503
29IRAK21.61416441
30TNIK1.56746082
31STK381.56719599
32TIE11.55771148
33OXSR11.55652725
34EPHA21.55054278
35STK161.54569625
36SIK11.52850566
37IRAK31.52533080
38RIPK41.45433810
39DAPK21.44401396
40IRAK11.42402971
41MARK31.39602668
42BMPR21.39316581
43ACVR1B1.37341827
44DYRK21.36432785
45LATS11.32653114
46TLK11.32449343
47TRIM281.27432920
48IRAK41.26182990
49STK391.24262728
50PAK31.22228221
51CAMKK21.20473481
52EIF2AK21.15939223
53CSNK1G21.09530155
54NTRK31.08688528
55AKT31.08681060
56CDK31.05982423
57CSNK1G31.05191615
58SGK2231.04729295
59SGK4941.04729295
60CSNK1G11.02669553
61SGK31.01347008
62MAP3K120.99609687
63CDK80.98793118
64MUSK0.97521447
65FGFR20.96955747
66MKNK20.94881562
67GRK10.92246046
68MAP2K60.91441881
69NLK0.89492889
70BRD40.88728816
71TEC0.88042567
72BCKDK0.87112980
73VRK10.85668466
74ADRBK10.84383841
75TRPM70.82340863
76PTK2B0.80616819
77PHKG20.77584026
78PHKG10.77584026
79TAOK20.77196810
80TAF10.76225344
81BCR0.73380736
82PLK40.73176486
83NEK60.72285033
84TNK20.71380640
85NME10.71018843
86CAMK1G0.68687416
87TSSK60.68236896
88WNK10.67155539
89STK30.66709669
90CDK190.65433416
91MKNK10.64598190
92BRSK20.64578527
93NUAK10.64487607
94MAP3K40.64357331
95PLK30.63758788
96CHEK20.61225988
97MARK20.57785492
98TGFBR10.55723548
99ATR0.55211802
100CLK10.54625500
101PIK3CA0.54614314
102JAK30.54560134
103PRKCG0.53473947
104PRKACA0.52090425
105WEE10.51864289
106FER0.51462441
107STK110.51029763
108PRKCE0.49101420
109SGK10.48203430
110MAPKAPK50.47326660
111PKN10.47012503
112TTK0.45620605
113MAPKAPK30.45572056
114IKBKB0.45041526
115EPHA40.44950425
116VRK20.44921661
117CAMK1D0.44076332
118EPHA30.43192689
119PRKCZ0.43149533
120EIF2AK30.41217484
121WNK40.40784471
122MAPK150.40392101
123PRKCH0.38629033
124JAK10.37298905
125PRKAA20.36564280
126RPS6KA50.36164077
127PRKACB0.36101098
128RPS6KB10.35717058
129PRKCI0.35603089
130CSNK1D0.35116708
131PRKG10.34216690
132PIK3CG0.34097163
133PRKCD0.33956754
134NTRK20.33854354
135GRK70.33366346
136LYN0.33267327
137CAMK10.32658623
138PRKCA0.32428483
139ERBB30.31720691
140MARK10.31678505
141MAP2K40.31544968
142EPHB20.30321754
143CSNK1E0.29283392
144PRKCQ0.26857673
145PRKAA10.26526075
146BTK0.25792031
147SRPK10.24422814
148IKBKE0.24337946
149DYRK1A0.24305207
150CSNK1A10.24247152
151CSNK1A1L0.23747388
152SYK0.23441768
153CAMK2A0.23214402

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.94675061
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.00743576
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.84181645
4Nicotine addiction_Homo sapiens_hsa050332.67054780
5Butanoate metabolism_Homo sapiens_hsa006502.52477211
6Oxidative phosphorylation_Homo sapiens_hsa001902.34453721
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.21533855
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16578988
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.13810275
10Protein export_Homo sapiens_hsa030602.02511291
11Fanconi anemia pathway_Homo sapiens_hsa034602.01597982
12Nitrogen metabolism_Homo sapiens_hsa009101.97015532
13Taste transduction_Homo sapiens_hsa047421.91849013
14Linoleic acid metabolism_Homo sapiens_hsa005911.91229867
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88997024
16Selenocompound metabolism_Homo sapiens_hsa004501.88424275
17Mineral absorption_Homo sapiens_hsa049781.87168842
18Parkinsons disease_Homo sapiens_hsa050121.86116723
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.80517299
20Fatty acid biosynthesis_Homo sapiens_hsa000611.78972531
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74821284
22RNA polymerase_Homo sapiens_hsa030201.63711293
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59089551
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58840271
25Propanoate metabolism_Homo sapiens_hsa006401.58285729
26Tryptophan metabolism_Homo sapiens_hsa003801.57837919
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56235857
28Cardiac muscle contraction_Homo sapiens_hsa042601.54053089
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50488861
30Allograft rejection_Homo sapiens_hsa053301.46650632
31Graft-versus-host disease_Homo sapiens_hsa053321.46404734
32Vitamin B6 metabolism_Homo sapiens_hsa007501.46077332
33Morphine addiction_Homo sapiens_hsa050321.45012604
34Autoimmune thyroid disease_Homo sapiens_hsa053201.44877113
35Rheumatoid arthritis_Homo sapiens_hsa053231.44056289
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43216493
37Caffeine metabolism_Homo sapiens_hsa002321.42268947
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.41860596
39Measles_Homo sapiens_hsa051621.39667278
40African trypanosomiasis_Homo sapiens_hsa051431.37924102
41Sphingolipid metabolism_Homo sapiens_hsa006001.36591570
42Peroxisome_Homo sapiens_hsa041461.34966036
43Basal transcription factors_Homo sapiens_hsa030221.34729460
44Arachidonic acid metabolism_Homo sapiens_hsa005901.33745873
45Insulin secretion_Homo sapiens_hsa049111.32608093
46Huntingtons disease_Homo sapiens_hsa050161.32397795
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29521686
48Calcium signaling pathway_Homo sapiens_hsa040201.27817289
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.26634943
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26624376
51Ether lipid metabolism_Homo sapiens_hsa005651.21743745
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.20640199
53Hematopoietic cell lineage_Homo sapiens_hsa046401.13586994
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11162589
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10202616
56Primary immunodeficiency_Homo sapiens_hsa053401.10167108
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08356045
58Alzheimers disease_Homo sapiens_hsa050101.08214877
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07600812
60One carbon pool by folate_Homo sapiens_hsa006701.04700886
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04298270
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03839072
63RNA degradation_Homo sapiens_hsa030181.02563738
64Glutamatergic synapse_Homo sapiens_hsa047241.02508024
65Circadian entrainment_Homo sapiens_hsa047130.97304462
66Ovarian steroidogenesis_Homo sapiens_hsa049130.96030120
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93042034
68Olfactory transduction_Homo sapiens_hsa047400.91767216
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90917006
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90684871
71Synaptic vesicle cycle_Homo sapiens_hsa047210.90439765
72Collecting duct acid secretion_Homo sapiens_hsa049660.86360542
73Serotonergic synapse_Homo sapiens_hsa047260.86290785
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83987141
75Proteasome_Homo sapiens_hsa030500.82655630
76Asthma_Homo sapiens_hsa053100.82597685
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82550601
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82281720
79Fat digestion and absorption_Homo sapiens_hsa049750.81965646
80Influenza A_Homo sapiens_hsa051640.81961765
81Type I diabetes mellitus_Homo sapiens_hsa049400.81348075
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.80868944
83Other glycan degradation_Homo sapiens_hsa005110.80476487
84Amphetamine addiction_Homo sapiens_hsa050310.78327456
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77601387
86beta-Alanine metabolism_Homo sapiens_hsa004100.77399453
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77391311
88Chemical carcinogenesis_Homo sapiens_hsa052040.76648010
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74370853
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73643114
91Metabolic pathways_Homo sapiens_hsa011000.72640468
92Dorso-ventral axis formation_Homo sapiens_hsa043200.72488720
93Salivary secretion_Homo sapiens_hsa049700.72151031
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71787056
95Regulation of autophagy_Homo sapiens_hsa041400.71756772
96Circadian rhythm_Homo sapiens_hsa047100.67678453
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67499702
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67491251
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67299489
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.67108363
101Homologous recombination_Homo sapiens_hsa034400.67002309
102TNF signaling pathway_Homo sapiens_hsa046680.66059491
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65927125
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65664914
105Legionellosis_Homo sapiens_hsa051340.65162507
106Fatty acid degradation_Homo sapiens_hsa000710.64775237
107Leishmaniasis_Homo sapiens_hsa051400.64331001
108Malaria_Homo sapiens_hsa051440.63291340
109Cocaine addiction_Homo sapiens_hsa050300.63259562
110Purine metabolism_Homo sapiens_hsa002300.62792900
111Glycerolipid metabolism_Homo sapiens_hsa005610.61902835
112Axon guidance_Homo sapiens_hsa043600.61645552
113cAMP signaling pathway_Homo sapiens_hsa040240.61109795
114Tuberculosis_Homo sapiens_hsa051520.60689251
115Ribosome_Homo sapiens_hsa030100.60154351
116Phototransduction_Homo sapiens_hsa047440.59322140
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59078019
118Herpes simplex infection_Homo sapiens_hsa051680.58915961
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57211215
120Renin secretion_Homo sapiens_hsa049240.56753718
121Retinol metabolism_Homo sapiens_hsa008300.56200617
122Osteoclast differentiation_Homo sapiens_hsa043800.56161613
123Phagosome_Homo sapiens_hsa041450.55369528
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54832308
125Fatty acid metabolism_Homo sapiens_hsa012120.54487099
126Sulfur metabolism_Homo sapiens_hsa009200.53647349
127Arginine and proline metabolism_Homo sapiens_hsa003300.53355140
128Steroid biosynthesis_Homo sapiens_hsa001000.53017853
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52890604
130T cell receptor signaling pathway_Homo sapiens_hsa046600.51209163
131Pyrimidine metabolism_Homo sapiens_hsa002400.51141885
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51033002
133Non-homologous end-joining_Homo sapiens_hsa034500.50918964
134Sulfur relay system_Homo sapiens_hsa041220.50635532
135ABC transporters_Homo sapiens_hsa020100.48924651
136RNA transport_Homo sapiens_hsa030130.47473739
137Wnt signaling pathway_Homo sapiens_hsa043100.46399449
138Salmonella infection_Homo sapiens_hsa051320.46081861
139Glutathione metabolism_Homo sapiens_hsa004800.43290177
140Vitamin digestion and absorption_Homo sapiens_hsa049770.42583838
141GABAergic synapse_Homo sapiens_hsa047270.42441868
142Hedgehog signaling pathway_Homo sapiens_hsa043400.41499199
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41173703
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.39605225
145Glucagon signaling pathway_Homo sapiens_hsa049220.39304289
146Dopaminergic synapse_Homo sapiens_hsa047280.39280694
147Pancreatic secretion_Homo sapiens_hsa049720.38447905
148Melanoma_Homo sapiens_hsa052180.37593952
149Ras signaling pathway_Homo sapiens_hsa040140.37128202
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37050552

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