TMEM241

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.44125688
2positive regulation of cellular amide metabolic process (GO:0034250)4.52742184
3positive regulation of gamma-delta T cell activation (GO:0046645)4.34468351
4pericardium development (GO:0060039)4.16473974
5regulation of dendritic cell antigen processing and presentation (GO:0002604)4.14367578
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01579244
7indolalkylamine metabolic process (GO:0006586)3.96775299
8startle response (GO:0001964)3.85655888
9tryptophan catabolic process (GO:0006569)3.83988289
10indole-containing compound catabolic process (GO:0042436)3.83988289
11indolalkylamine catabolic process (GO:0046218)3.83988289
12superoxide anion generation (GO:0042554)3.83963013
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.79576100
14response to pheromone (GO:0019236)3.73618961
15kynurenine metabolic process (GO:0070189)3.68443753
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65635106
17positive regulation of antigen processing and presentation (GO:0002579)3.59353625
18detection of light stimulus involved in sensory perception (GO:0050962)3.49848855
19detection of light stimulus involved in visual perception (GO:0050908)3.49848855
20regulation of activation of Janus kinase activity (GO:0010533)3.49833825
21polyketide metabolic process (GO:0030638)3.48820271
22doxorubicin metabolic process (GO:0044598)3.48820271
23daunorubicin metabolic process (GO:0044597)3.48820271
24neural tube formation (GO:0001841)3.45114813
25negative regulation of mast cell activation (GO:0033004)3.41417526
26regulation of fever generation (GO:0031620)3.36786509
27tryptophan metabolic process (GO:0006568)3.32417204
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31742831
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.31742831
30modulation by symbiont of host immune response (GO:0052553)3.31742831
31positive regulation by symbiont of host defense response (GO:0052509)3.31742831
32modulation by symbiont of host defense response (GO:0052031)3.31742831
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31742831
34dendritic cell chemotaxis (GO:0002407)3.31189470
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28622287
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28317506
37regulation of antigen processing and presentation (GO:0002577)3.26684587
38regulation of heat generation (GO:0031650)3.23797153
39auditory behavior (GO:0031223)3.21683562
40mesenchymal cell differentiation involved in renal system development (GO:2001012)3.19853888
41mesenchymal cell differentiation involved in kidney development (GO:0072161)3.19853888
42epithelial cilium movement (GO:0003351)3.17285664
43NADH dehydrogenase complex assembly (GO:0010257)3.15837536
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15837536
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.15837536
46serotonin metabolic process (GO:0042428)3.15264559
47indole-containing compound metabolic process (GO:0042430)3.12880714
48gamma-aminobutyric acid transport (GO:0015812)3.12838409
49cell differentiation involved in metanephros development (GO:0072202)3.12459692
50L-fucose catabolic process (GO:0042355)3.12267344
51fucose catabolic process (GO:0019317)3.12267344
52L-fucose metabolic process (GO:0042354)3.12267344
53regulation of action potential (GO:0098900)3.12090155
54pharyngeal system development (GO:0060037)3.06702622
55neuronal action potential (GO:0019228)3.05134055
56interferon-gamma production (GO:0032609)3.03166305
57detection of other organism (GO:0098543)3.02173700
58mannosylation (GO:0097502)3.01467481
59mechanosensory behavior (GO:0007638)3.01404792
60mitochondrial respiratory chain complex assembly (GO:0033108)3.00009835
61protein-cofactor linkage (GO:0018065)2.99151782
62platelet dense granule organization (GO:0060155)2.98575685
63dendritic cell migration (GO:0036336)2.97391162
64detection of molecule of bacterial origin (GO:0032490)2.96991156
65regulation of B cell receptor signaling pathway (GO:0050855)2.96094003
66regulation of penile erection (GO:0060405)2.94540636
67atrial cardiac muscle cell action potential (GO:0086014)2.94300271
68primary amino compound metabolic process (GO:1901160)2.90909123
69nonmotile primary cilium assembly (GO:0035058)2.88797913
70ganglion development (GO:0061548)2.87592412
71cellular ketone body metabolic process (GO:0046950)2.86390877
72nucleotide transmembrane transport (GO:1901679)2.86249487
73regulation of cilium movement (GO:0003352)2.86093203
74cellular anion homeostasis (GO:0030002)2.84548508
75activated T cell proliferation (GO:0050798)2.84416406
76microglial cell activation (GO:0001774)2.84235212
77cornea development in camera-type eye (GO:0061303)2.79525104
78presynaptic membrane assembly (GO:0097105)2.77122800
79tachykinin receptor signaling pathway (GO:0007217)2.76402048
80dentate gyrus development (GO:0021542)2.73845765
81synaptic transmission, cholinergic (GO:0007271)2.71852621
82cilium movement (GO:0003341)2.71136346
83respiratory chain complex IV assembly (GO:0008535)2.70048734
84membrane depolarization during action potential (GO:0086010)2.68488088
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68461404
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67569257
87regulation of hippo signaling (GO:0035330)2.67325924
88piRNA metabolic process (GO:0034587)2.66341155
89cilium or flagellum-dependent cell motility (GO:0001539)2.65187296
90transmission of nerve impulse (GO:0019226)2.64442330
91ketone body metabolic process (GO:1902224)2.63870091
92kidney morphogenesis (GO:0060993)2.63284541
93DNA double-strand break processing (GO:0000729)2.62977295
94magnesium ion transport (GO:0015693)2.62877671
95axoneme assembly (GO:0035082)2.62634477
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62253617
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.62253617
98ubiquinone biosynthetic process (GO:0006744)2.61902994
99cilium organization (GO:0044782)2.61702033
100behavioral response to ethanol (GO:0048149)2.61651731
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.61184489
102poly(A)+ mRNA export from nucleus (GO:0016973)2.60615980
103ubiquinone metabolic process (GO:0006743)2.59381116
104oligosaccharide catabolic process (GO:0009313)2.58596128
105recombinational repair (GO:0000725)2.58414364
106regulation of cell maturation (GO:1903429)2.58295052
107double-strand break repair via homologous recombination (GO:0000724)2.57516815
108cytochrome complex assembly (GO:0017004)2.56840158
109DNA methylation involved in gamete generation (GO:0043046)2.55949304
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.55789851
111spinal cord motor neuron differentiation (GO:0021522)2.55780287
112response to auditory stimulus (GO:0010996)2.55001182
113positive regulation of heat generation (GO:0031652)2.54509046
114cilium morphogenesis (GO:0060271)2.54483567
115water-soluble vitamin biosynthetic process (GO:0042364)2.54328914
116detection of bacterium (GO:0016045)2.54113784
117positive regulation of interleukin-1 beta secretion (GO:0050718)2.53986429
118centriole replication (GO:0007099)2.53403098
119phasic smooth muscle contraction (GO:0014821)2.53402291
120cilium assembly (GO:0042384)2.53053407
121protein localization to cilium (GO:0061512)2.51614262
122regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51340095
123intraciliary transport (GO:0042073)2.51185925
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50620356
125response to host immune response (GO:0052572)2.50620356
126regulation of gamma-delta T cell activation (GO:0046643)2.50362498
127aggressive behavior (GO:0002118)2.50160255
128presynaptic membrane organization (GO:0097090)2.50145434
129regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.50072320
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49757707
131detection of biotic stimulus (GO:0009595)2.49180164
132peristalsis (GO:0030432)2.49073840
133reciprocal meiotic recombination (GO:0007131)2.48601680
134reciprocal DNA recombination (GO:0035825)2.48601680
135dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.47826776
136photoreceptor cell maintenance (GO:0045494)2.47628474
137photoreceptor cell development (GO:0042461)2.47503015
138axonemal dynein complex assembly (GO:0070286)2.46892777
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.46828465
140rRNA catabolic process (GO:0016075)2.46733809
141negative regulation of glycogen biosynthetic process (GO:0045719)2.46309344
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45327814
143valine metabolic process (GO:0006573)2.44884398
144detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44824895
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44786142
146protein K11-linked deubiquitination (GO:0035871)2.44547840
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44499220
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.44499220
149regulation of translation, ncRNA-mediated (GO:0045974)2.44499220
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44052235
151rhodopsin mediated signaling pathway (GO:0016056)2.43619595
152purine ribonucleotide transport (GO:0015868)2.43394049
153pyrimidine nucleobase catabolic process (GO:0006208)2.43128996
154signal peptide processing (GO:0006465)2.42877230
155DNA deamination (GO:0045006)2.42809748
156positive regulation of uterine smooth muscle contraction (GO:0070474)2.42286408
157positive regulation of growth hormone secretion (GO:0060124)2.41759354
158negative regulation of glycoprotein metabolic process (GO:1903019)2.40902244
159extracellular negative regulation of signal transduction (GO:1900116)2.39394218
160extracellular regulation of signal transduction (GO:1900115)2.39394218
161sulfation (GO:0051923)2.39365587
162protein complex biogenesis (GO:0070271)2.39045744
163mitochondrion distribution (GO:0048311)2.37633293
164adenine nucleotide transport (GO:0051503)2.36608518
165positive regulation of protein homodimerization activity (GO:0090073)2.35801734
166embryonic epithelial tube formation (GO:0001838)2.35465721
167preassembly of GPI anchor in ER membrane (GO:0016254)2.35413382
168phospholipid scrambling (GO:0017121)2.34657608
169metallo-sulfur cluster assembly (GO:0031163)2.34243951
170iron-sulfur cluster assembly (GO:0016226)2.34243951
171opioid receptor signaling pathway (GO:0038003)2.33510448
172detection of external biotic stimulus (GO:0098581)2.32764982
173response to host (GO:0075136)2.32311884
174response to host defenses (GO:0052200)2.32311884
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32311884
176GPI anchor biosynthetic process (GO:0006506)2.30963684
177negative regulation of stem cell proliferation (GO:2000647)2.30816072
178negative regulation of glycogen metabolic process (GO:0070874)2.30679613
179positive regulation of NF-kappaB import into nucleus (GO:0042346)2.30274926
180mesenchymal cell differentiation (GO:0048762)2.29816844
181reflex (GO:0060004)2.28182183
182regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27941425
183positive regulation of interleukin-1 secretion (GO:0050716)2.27788246
184regulation of T cell chemotaxis (GO:0010819)2.27342138
185positive regulation of T cell chemotaxis (GO:0010820)2.27342138
186GPI anchor metabolic process (GO:0006505)2.26453937
187cellular biogenic amine catabolic process (GO:0042402)2.26249588
188amine catabolic process (GO:0009310)2.26249588
189serotonin receptor signaling pathway (GO:0007210)2.24921422
190meiotic chromosome segregation (GO:0045132)2.24561240
191cell differentiation involved in kidney development (GO:0061005)2.24329036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.71589979
2ZNF274_21170338_ChIP-Seq_K562_Hela3.81459050
3VDR_22108803_ChIP-Seq_LS180_Human3.26630335
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16992314
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.97522086
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.60573326
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55680016
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51829662
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42386444
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.42313372
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32599236
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.22657717
13P300_19829295_ChIP-Seq_ESCs_Human2.13759032
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.12438088
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08782298
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.00355595
17NFE2_27457419_Chip-Seq_LIVER_Mouse1.99851877
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92887126
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91619992
20TAF15_26573619_Chip-Seq_HEK293_Human1.90714629
21IGF1R_20145208_ChIP-Seq_DFB_Human1.89697654
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89571836
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84658084
24FUS_26573619_Chip-Seq_HEK293_Human1.82947199
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.82809928
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81745280
27EWS_26573619_Chip-Seq_HEK293_Human1.80696770
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.79411348
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79345332
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.78979601
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.76493759
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.76025438
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.75487887
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75373204
35SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74218246
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.72749165
37P53_22387025_ChIP-Seq_ESCs_Mouse1.69715739
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68015814
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64754769
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.63640660
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.63197099
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62798900
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61861288
44EZH2_22144423_ChIP-Seq_EOC_Human1.60008311
45BCAT_22108803_ChIP-Seq_LS180_Human1.59137334
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.58802460
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.58121183
48CBP_20019798_ChIP-Seq_JUKART_Human1.57702009
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57702009
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56921221
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.56784053
52SMAD4_21799915_ChIP-Seq_A2780_Human1.55183674
53ER_23166858_ChIP-Seq_MCF-7_Human1.54671412
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52897688
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.52752287
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52565615
57P300_18555785_Chip-Seq_ESCs_Mouse1.52551773
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52025838
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51112869
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48310053
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.46579680
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.45220942
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.44878639
64REST_21632747_ChIP-Seq_MESCs_Mouse1.43438864
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42575496
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41853725
67TP53_22573176_ChIP-Seq_HFKS_Human1.40313645
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.39284722
69AR_21572438_ChIP-Seq_LNCaP_Human1.38493726
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38363563
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.38080227
72PU1_27457419_Chip-Seq_LIVER_Mouse1.37801058
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36189698
74STAT3_23295773_ChIP-Seq_U87_Human1.36031565
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35460268
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34242634
77RNF2_27304074_Chip-Seq_NSC_Mouse1.34188894
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33543148
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33442186
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32801521
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.32801521
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.32567297
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32537862
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32029266
85MYC_18940864_ChIP-ChIP_HL60_Human1.31793866
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31574814
87AR_25329375_ChIP-Seq_VCAP_Human1.31246709
88* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30536369
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27863148
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27608994
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26800612
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26800612
93TCF4_22108803_ChIP-Seq_LS180_Human1.26263163
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24412359
95KLF4_18555785_Chip-Seq_ESCs_Mouse1.24379682
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24317157
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24216985
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24004537
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.23613174
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22353089
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22098564
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.22013730
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20446738
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20241609
105IRF1_19129219_ChIP-ChIP_H3396_Human1.19924507
106ELK1_19687146_ChIP-ChIP_HELA_Human1.19273136
107SOX2_19829295_ChIP-Seq_ESCs_Human1.18604043
108NANOG_19829295_ChIP-Seq_ESCs_Human1.18604043
109TCF4_23295773_ChIP-Seq_U87_Human1.18394367
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17583707
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.17089446
112RUNX2_22187159_ChIP-Seq_PCA_Human1.17065674
113JUN_21703547_ChIP-Seq_K562_Human1.14256578
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.13343834
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12467489
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.11294123
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10964660
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10876483
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10533018
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10369252
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09740631
122RUNX_20019798_ChIP-Seq_JUKART_Human1.09710811
123KDM2B_26808549_Chip-Seq_REH_Human1.08946255
124NCOR_22424771_ChIP-Seq_293T_Human1.08751806
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08030653
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07405214
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07365147
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07301592
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07205128
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.06467035
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06090446
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.05646229
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05618772
134NOTCH1_21737748_ChIP-Seq_TLL_Human1.05585587
135SOX9_26525672_Chip-Seq_HEART_Mouse1.04834263
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03447953
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02083846
138CDX2_22108803_ChIP-Seq_LS180_Human1.01681293
139GATA3_21878914_ChIP-Seq_MCF-7_Human1.01226147
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00627400
141AR_20517297_ChIP-Seq_VCAP_Human0.98931918
142HOXB7_26014856_ChIP-Seq_BT474_Human0.98144544
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97148805
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96650067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.52117627
2MP0005171_absent_coat_pigmentation3.79349344
3MP0005645_abnormal_hypothalamus_physiol3.51941237
4MP0002876_abnormal_thyroid_physiology3.32610469
5MP0001986_abnormal_taste_sensitivity2.96119893
6MP0009697_abnormal_copulation2.86976869
7MP0001835_abnormal_antigen_presentation2.86592043
8MP0001188_hyperpigmentation2.74273925
9MP0002102_abnormal_ear_morphology2.53276357
10MP0005551_abnormal_eye_electrophysiolog2.36797699
11MP0005646_abnormal_pituitary_gland2.35087669
12MP0002735_abnormal_chemical_nociception2.32460072
13MP0002736_abnormal_nociception_after2.31495495
14MP0000372_irregular_coat_pigmentation2.28757716
15MP0000566_synostosis2.27929393
16MP0008877_abnormal_DNA_methylation2.27544167
17MP0002254_reproductive_system_inflammat2.21476798
18MP0003195_calcinosis2.20305390
19MP0005409_darkened_coat_color2.17623444
20MP0003880_abnormal_central_pattern2.17129647
21MP0000569_abnormal_digit_pigmentation2.15415536
22MP0006082_CNS_inflammation1.99486137
23MP0006292_abnormal_olfactory_placode1.98190810
24MP0005671_abnormal_response_to1.90838554
25MP0005083_abnormal_biliary_tract1.88721218
26MP0002837_dystrophic_cardiac_calcinosis1.86156130
27MP0005670_abnormal_white_adipose1.85887486
28MP0000015_abnormal_ear_pigmentation1.81993509
29MP0008058_abnormal_DNA_repair1.76237587
30MP0003646_muscle_fatigue1.75563150
31MP0002638_abnormal_pupillary_reflex1.73234443
32MP0002272_abnormal_nervous_system1.69394107
33MP0005253_abnormal_eye_physiology1.69225771
34MP0003183_abnormal_peptide_metabolism1.68141629
35MP0004142_abnormal_muscle_tone1.66148799
36MP0003718_maternal_effect1.65170051
37MP0003724_increased_susceptibility_to1.63023148
38MP0005084_abnormal_gallbladder_morpholo1.62663798
39MP0006072_abnormal_retinal_apoptosis1.61641823
40MP0008872_abnormal_physiological_respon1.60898425
41MP0002163_abnormal_gland_morphology1.60512152
42MP0004133_heterotaxia1.59991460
43MP0002148_abnormal_hypersensitivity_rea1.57713589
44MP0003787_abnormal_imprinting1.52128538
45MP0008995_early_reproductive_senescence1.51232161
46MP0001968_abnormal_touch/_nociception1.49012380
47MP0004043_abnormal_pH_regulation1.48958154
48MP0000427_abnormal_hair_cycle1.48906104
49MP0002419_abnormal_innate_immunity1.46176931
50MP0008260_abnormal_autophagy1.42509459
51MP0004145_abnormal_muscle_electrophysio1.41589806
52MP0001502_abnormal_circadian_rhythm1.40980576
53MP0005310_abnormal_salivary_gland1.38142650
54MP0010386_abnormal_urinary_bladder1.37262492
55MP0004885_abnormal_endolymph1.36317578
56MP0001485_abnormal_pinna_reflex1.35847812
57MP0002160_abnormal_reproductive_system1.35187957
58MP0009785_altered_susceptibility_to1.32803226
59MP0005387_immune_system_phenotype1.32486761
60MP0001790_abnormal_immune_system1.32486761
61MP0000383_abnormal_hair_follicle1.32287938
62MP0001529_abnormal_vocalization1.29410351
63MP0002064_seizures1.28551970
64MP0002733_abnormal_thermal_nociception1.28024647
65MP0003763_abnormal_thymus_physiology1.27023597
66MP0001970_abnormal_pain_threshold1.26651163
67MP0001501_abnormal_sleep_pattern1.26623798
68MP0005379_endocrine/exocrine_gland_phen1.24203622
69MP0005386_behavior/neurological_phenoty1.23493018
70MP0004924_abnormal_behavior1.23493018
71MP0002653_abnormal_ependyma_morphology1.23415226
72MP0002132_abnormal_respiratory_system1.21065613
73MP0002234_abnormal_pharynx_morphology1.20412017
74MP0005647_abnormal_sex_gland1.20400079
75MP0003011_delayed_dark_adaptation1.19859491
76MP0002184_abnormal_innervation1.18623493
77MP0002452_abnormal_antigen_presenting1.18399989
78MP0009764_decreased_sensitivity_to1.17401212
79MP0004782_abnormal_surfactant_physiolog1.15848679
80MP0001819_abnormal_immune_cell1.15075549
81MP0005423_abnormal_somatic_nervous1.14019824
82MP0002822_catalepsy1.13884415
83MP0002420_abnormal_adaptive_immunity1.13857884
84MP0003121_genomic_imprinting1.13651309
85MP0002734_abnormal_mechanical_nocicepti1.12689326
86MP0001800_abnormal_humoral_immune1.11774940
87MP0003950_abnormal_plasma_membrane1.11384889
88MP0003937_abnormal_limbs/digits/tail_de1.10905300
89MP0005451_abnormal_body_composition1.10349872
90MP0003635_abnormal_synaptic_transmissio1.09446725
91MP0005025_abnormal_response_to1.07341427
92MP0005000_abnormal_immune_tolerance1.07290759
93MP0002938_white_spotting1.06633750
94MP0003122_maternal_imprinting1.05826869
95MP0002723_abnormal_immune_serum1.05362232
96MP0004215_abnormal_myocardial_fiber1.05043350
97MP0000647_abnormal_sebaceous_gland1.04994608
98MP0001186_pigmentation_phenotype1.02703807
99MP0009745_abnormal_behavioral_response1.02546569
100MP0002752_abnormal_somatic_nervous1.02012618
101MP0005389_reproductive_system_phenotype1.01956851
102MP0002095_abnormal_skin_pigmentation1.01871420
103MP0003890_abnormal_embryonic-extraembry1.01431939
104MP0003786_premature_aging1.00807883
105MP0001764_abnormal_homeostasis0.99432051
106MP0003172_abnormal_lysosome_physiology0.99022971
107MP0008875_abnormal_xenobiotic_pharmacok0.98578033
108MP0002282_abnormal_trachea_morphology0.96194454
109MP0009384_cardiac_valve_regurgitation0.95990731
110MP0001905_abnormal_dopamine_level0.95485815
111MP0002933_joint_inflammation0.95187769
112MP0005195_abnormal_posterior_eye0.95140428
113MP0005187_abnormal_penis_morphology0.95018184
114MP0002277_abnormal_respiratory_mucosa0.94577146
115MP0001963_abnormal_hearing_physiology0.94293130
116MP0009765_abnormal_xenobiotic_induced0.93761932
117MP0002063_abnormal_learning/memory/cond0.93617656
118MP0001984_abnormal_olfaction0.92284346
119MP0000685_abnormal_immune_system0.90928339
120MP0003698_abnormal_male_reproductive0.89229499
121MP0000955_abnormal_spinal_cord0.89026466
122MP0002572_abnormal_emotion/affect_behav0.88731958
123MP0002229_neurodegeneration0.87849759
124MP0005075_abnormal_melanosome_morpholog0.87455273
125MP0002928_abnormal_bile_duct0.86765948
126MP0009046_muscle_twitch0.86066342
127MP0000026_abnormal_inner_ear0.85899198
128MP0001324_abnormal_eye_pigmentation0.84811426
129MP0005410_abnormal_fertilization0.84227578
130MP0002210_abnormal_sex_determination0.83480067
131MP0010368_abnormal_lymphatic_system0.83057405
132MP0008057_abnormal_DNA_replication0.82901120
133MP0002557_abnormal_social/conspecific_i0.82838494
134MP0002882_abnormal_neuron_morphology0.82468789
135MP0001929_abnormal_gametogenesis0.80660809
136MP0006276_abnormal_autonomic_nervous0.80494784
137MP0002067_abnormal_sensory_capabilities0.78894059
138MP0001879_abnormal_lymphatic_vessel0.78865659
139MP0001853_heart_inflammation0.78023557
140MP0000716_abnormal_immune_system0.77517952
141MP0004742_abnormal_vestibular_system0.77278564
142MP0001919_abnormal_reproductive_system0.77225382
143MP0001346_abnormal_lacrimal_gland0.76511611
144MP0001486_abnormal_startle_reflex0.76454527
145MP0001119_abnormal_female_reproductive0.76419395
146MP0000465_gastrointestinal_hemorrhage0.74222253
147MP0002075_abnormal_coat/hair_pigmentati0.73156185
148MP0001177_atelectasis0.73120245
149MP0002751_abnormal_autonomic_nervous0.72529818
150MP0002398_abnormal_bone_marrow0.72355852
151MP0006054_spinal_hemorrhage0.70639014
152MP0000631_abnormal_neuroendocrine_gland0.69313112
153MP0000778_abnormal_nervous_system0.69037602
154MP0004147_increased_porphyrin_level0.67778397
155MP0001542_abnormal_bone_strength0.67183863
156MP0005257_abnormal_intraocular_pressure0.66980015
157MP0001845_abnormal_inflammatory_respons0.66124530
158MP0001270_distended_abdomen0.65633740
159MP0005174_abnormal_tail_pigmentation0.65115337

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26504523
2White forelock (HP:0002211)4.03583881
3Patchy hypopigmentation of hair (HP:0011365)3.91023825
4Molar tooth sign on MRI (HP:0002419)3.76666978
5Abnormality of midbrain morphology (HP:0002418)3.76666978
6Congenital stationary night blindness (HP:0007642)3.64951873
7Chromsome breakage (HP:0040012)3.62745123
8Type I transferrin isoform profile (HP:0003642)3.56356734
9Nephronophthisis (HP:0000090)3.44038877
10Type II lissencephaly (HP:0007260)3.43594501
11Chronic hepatic failure (HP:0100626)3.40986613
12Abnormal hair whorl (HP:0010721)3.40417127
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.17351707
14Hypoplasia of the fovea (HP:0007750)3.17351707
15Duplicated collecting system (HP:0000081)3.09858829
16Reduced antithrombin III activity (HP:0001976)2.97656486
17Abnormality of the renal medulla (HP:0100957)2.96496416
18Gaze-evoked nystagmus (HP:0000640)2.94993974
19Blue irides (HP:0000635)2.94195716
20True hermaphroditism (HP:0010459)2.91623566
21Progressive cerebellar ataxia (HP:0002073)2.82703510
22Febrile seizures (HP:0002373)2.81996249
23Abnormality of the renal collecting system (HP:0004742)2.79367325
24Cerebellar dysplasia (HP:0007033)2.76355277
25Congenital malformation of the right heart (HP:0011723)2.73568271
26Double outlet right ventricle (HP:0001719)2.73568271
27Hypergonadotropic hypogonadism (HP:0000815)2.66459741
28Cystic liver disease (HP:0006706)2.62503501
29Renal cortical cysts (HP:0000803)2.61321300
30Genetic anticipation (HP:0003743)2.59137938
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.58783490
32Absent/shortened dynein arms (HP:0200106)2.58783490
33Sclerocornea (HP:0000647)2.58670908
34Retrobulbar optic neuritis (HP:0100654)2.57753349
35Optic neuritis (HP:0100653)2.57753349
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57534386
37Abnormal protein N-linked glycosylation (HP:0012347)2.57534386
38Abnormal protein glycosylation (HP:0012346)2.57534386
39Abnormal glycosylation (HP:0012345)2.57534386
40Lissencephaly (HP:0001339)2.56323425
41Increased corneal curvature (HP:0100692)2.55676150
42Keratoconus (HP:0000563)2.55676150
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.55577382
44Attenuation of retinal blood vessels (HP:0007843)2.54923239
45Tubular atrophy (HP:0000092)2.53897441
46Abnormality of the fovea (HP:0000493)2.51325960
47Pendular nystagmus (HP:0012043)2.44028408
48Abnormal respiratory motile cilium morphology (HP:0005938)2.43720198
49Abnormal respiratory epithelium morphology (HP:0012253)2.43720198
50Hypothermia (HP:0002045)2.42632311
51Medial flaring of the eyebrow (HP:0010747)2.40946575
52Clubbing of toes (HP:0100760)2.40746644
53Small hand (HP:0200055)2.40223423
54Submucous cleft hard palate (HP:0000176)2.39668965
55Pancreatic fibrosis (HP:0100732)2.29467212
56Occipital encephalocele (HP:0002085)2.29297022
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.29267196
58Recurrent pneumonia (HP:0006532)2.29261441
59Hyperventilation (HP:0002883)2.28912686
60Furrowed tongue (HP:0000221)2.26081037
61Anencephaly (HP:0002323)2.25863722
62Recurrent cutaneous fungal infections (HP:0011370)2.25094581
63Chronic mucocutaneous candidiasis (HP:0002728)2.25094581
64Epileptic encephalopathy (HP:0200134)2.24772929
65Recurrent abscess formation (HP:0002722)2.24664923
66Abnormality of the pons (HP:0007361)2.24384948
67Hypoplasia of the pons (HP:0012110)2.24012010
68Eczematoid dermatitis (HP:0000976)2.23864637
69Abnormal ciliary motility (HP:0012262)2.21883123
70Decreased central vision (HP:0007663)2.20832091
71Abnormal rod and cone electroretinograms (HP:0008323)2.20488087
72Inability to walk (HP:0002540)2.19858522
73Genital tract atresia (HP:0001827)2.18632133
74Panhypogammaglobulinemia (HP:0003139)2.18350306
75Abolished electroretinogram (ERG) (HP:0000550)2.17202758
76Nephrogenic diabetes insipidus (HP:0009806)2.16820828
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.16761678
78Fair hair (HP:0002286)2.16646255
79Acute encephalopathy (HP:0006846)2.16366612
80Acute necrotizing encephalopathy (HP:0006965)2.16344270
81Preaxial hand polydactyly (HP:0001177)2.15757261
82Xerostomia (HP:0000217)2.14177863
83Pancreatic cysts (HP:0001737)2.12747185
84Chronic diarrhea (HP:0002028)2.11964749
85Vaginal atresia (HP:0000148)2.11675288
86Focal seizures (HP:0007359)2.10660483
87Abnormality of incisor morphology (HP:0011063)2.10156911
88Increased CSF lactate (HP:0002490)2.09773989
89Abnormality of the labia minora (HP:0012880)2.09528980
90Hypoplastic left heart (HP:0004383)2.09359905
91Agammaglobulinemia (HP:0004432)2.07854824
92Concave nail (HP:0001598)2.07502603
93Hypoplastic heart (HP:0001961)2.07313996
94Patellar aplasia (HP:0006443)2.06661351
95Retinal dysplasia (HP:0007973)2.04541939
96Adrenal hypoplasia (HP:0000835)2.04249877
97Abnormality of macular pigmentation (HP:0008002)2.04160321
98Abnormal respiratory motile cilium physiology (HP:0012261)2.03375861
99Meckel diverticulum (HP:0002245)2.03082105
100Large for gestational age (HP:0001520)2.03072207
101Progressive inability to walk (HP:0002505)2.02946142
102Abnormal drinking behavior (HP:0030082)2.02545190
103Polydipsia (HP:0001959)2.02545190
104Mitochondrial inheritance (HP:0001427)2.02479657
105Severe combined immunodeficiency (HP:0004430)2.02276733
106Abnormality of the preputium (HP:0100587)2.02194203
107Intestinal atresia (HP:0011100)2.01541364
108Ectopic kidney (HP:0000086)2.01540582
109Aplasia/Hypoplasia of the patella (HP:0006498)2.01299853
110Broad-based gait (HP:0002136)2.01203483
111Aplasia/Hypoplasia of the macula (HP:0008059)2.01171940
112Focal motor seizures (HP:0011153)2.00601344
113Male pseudohermaphroditism (HP:0000037)2.00475642
114Thyroiditis (HP:0100646)2.00459414
115Congenital hepatic fibrosis (HP:0002612)2.00298712
116Congenital primary aphakia (HP:0007707)1.99930352
117Protruding tongue (HP:0010808)1.97662918
118Alveolar cell carcinoma (HP:0006519)1.97624763
119Abnormality of the ileum (HP:0001549)1.96930776
120Bony spicule pigmentary retinopathy (HP:0007737)1.96925998
121Myositis (HP:0100614)1.96334247
122Dialeptic seizures (HP:0011146)1.96242660
123Bile duct proliferation (HP:0001408)1.95664637
124Abnormal biliary tract physiology (HP:0012439)1.95664637
125Short tibia (HP:0005736)1.95222613
126Chorioretinal atrophy (HP:0000533)1.93588800
127Abnormality of alanine metabolism (HP:0010916)1.92464464
128Hyperalaninemia (HP:0003348)1.92464464
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92464464
130Gait imbalance (HP:0002141)1.92295593
131Meningitis (HP:0001287)1.91999173
132Progressive macrocephaly (HP:0004481)1.90605096
133Growth hormone deficiency (HP:0000824)1.89871784
134Congenital, generalized hypertrichosis (HP:0004540)1.87627029
135Limb dystonia (HP:0002451)1.85319672
136Methylmalonic acidemia (HP:0002912)1.84630204
137Recurrent fungal infections (HP:0002841)1.83787877
138Keratoconjunctivitis (HP:0001096)1.82903429
139Neonatal hypoglycemia (HP:0001998)1.81651410
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81525849
141Prostate neoplasm (HP:0100787)1.81406228
142Poor coordination (HP:0002370)1.81367604
143Optic disc pallor (HP:0000543)1.80797515
144Hyperglycinuria (HP:0003108)1.80612480
145Generalized hypopigmentation of hair (HP:0011358)1.80141390
146Pachygyria (HP:0001302)1.80095704
147Follicular hyperkeratosis (HP:0007502)1.79427479
148Postaxial foot polydactyly (HP:0001830)1.78813820
149Orchitis (HP:0100796)1.78308213
150Absent speech (HP:0001344)1.78074558
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77403213
152Prolonged neonatal jaundice (HP:0006579)1.77371309
153Hyperglycinemia (HP:0002154)1.77230549
154Birth length less than 3rd percentile (HP:0003561)1.77081841
155Dandy-Walker malformation (HP:0001305)1.76469645
156Recurrent bacterial skin infections (HP:0005406)1.76459452
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76346553
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75503201
159Absent eyebrow (HP:0002223)1.74990268
160Homocystinuria (HP:0002156)1.74932771
161Abnormality of homocysteine metabolism (HP:0010919)1.74932771
162Abnormal lung lobation (HP:0002101)1.74895439
163Postaxial hand polydactyly (HP:0001162)1.72706413
164Recurrent skin infections (HP:0001581)1.72684856
165Abnormal mitochondria in muscle tissue (HP:0008316)1.72660196
166Stomatitis (HP:0010280)1.71553304
167Duplication of thumb phalanx (HP:0009942)1.70876967
168Recurrent gram-negative bacterial infections (HP:0005420)1.70225427
169Abnormality of the renal cortex (HP:0011035)1.68342063
170Abnormality of the columella (HP:0009929)1.68108434
171Keratitis (HP:0000491)1.66303489
172Conical tooth (HP:0000698)1.66254019
173Optic nerve hypoplasia (HP:0000609)1.66057611
174Bone marrow hypocellularity (HP:0005528)1.65944823
175Dry hair (HP:0011359)1.64718875
176Hypoplasia of the thymus (HP:0000778)1.63992200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07958881
2CASK4.33377971
3TNIK3.40332388
4MKNK23.17431199
5TXK3.14972225
6PASK2.98582561
7MAP3K142.75567312
8CCNB12.75320906
9MAP2K72.70516951
10SIK32.61665969
11AKT32.33468764
12NUAK12.28493471
13PNCK2.18657015
14MKNK12.16693546
15WNK42.15788042
16ACVR1B2.14557669
17PRPF4B2.10612296
18SGK22.02473064
19MUSK1.97832661
20MAP4K21.94504487
21INSRR1.82568615
22JAK31.72616106
23EIF2AK21.72486410
24ZAK1.71372292
25CAMKK21.68202528
26STK391.67416597
27ERBB31.65519751
28TLK11.65090563
29GRK71.62467865
30NEK61.57198470
31PLK21.54814568
32MAP3K121.54388054
33ADRBK21.52965368
34SRPK11.51995968
35TRIM281.50459295
36BRSK21.46451172
37VRK21.38984030
38TEC1.38386012
39EPHA31.35793461
40OXSR11.34023296
41CDK81.31645369
42WEE11.30844654
43SGK31.26214035
44MARK11.26092649
45FLT31.24645376
46BTK1.24086340
47PAK31.23048502
48ADRBK11.22270363
49IRAK31.22015771
50MAPK131.21966155
51BMPR21.20281383
52NLK1.15314558
53TAF11.14553403
54MAPK71.13441853
55IRAK41.12705922
56SGK4941.10948033
57SGK2231.10948033
58YES11.10215313
59EIF2AK31.10184971
60TGFBR21.05544389
61BMPR1B1.00371419
62TIE10.97216756
63STK160.94928509
64DYRK20.92669728
65BCR0.92489127
66LYN0.92005534
67RPS6KB10.88236716
68MAPKAPK50.87951589
69CSF1R0.87238918
70STK38L0.86744150
71IKBKE0.86303400
72SYK0.85719506
73KIT0.85684271
74MAPK150.85279489
75TGFBR10.83492433
76CDK30.81463116
77GRK10.81198597
78VRK10.80351145
79TSSK60.80060443
80FES0.79691226
81STK30.79409825
82MAPK120.77103023
83CAMK1D0.75774371
84EIF2AK10.75534586
85JAK10.73007142
86CAMK1G0.72199950
87CSNK1G20.71763510
88MAPKAPK30.70829575
89NEK20.70121776
90PRKCE0.69988487
91PINK10.69822233
92NTRK20.68136401
93BCKDK0.67993615
94CHUK0.66425629
95NME10.64958457
96IKBKB0.62071765
97DAPK20.62029924
98MINK10.61206612
99SIK20.61166364
100CSNK1G30.60635896
101CSNK1G10.59383700
102MST40.59134953
103MAP4K10.57484133
104PLK10.56586500
105IGF1R0.54813580
106LCK0.54283486
107STK240.53531042
108EPHA40.53505095
109ITK0.52543717
110NTRK30.52400944
111CAMK2A0.51873266
112RPS6KA50.50961226
113PRKCI0.50600658
114MAP2K40.50047046
115SGK10.49079270
116MAP3K40.48415389
117PTK2B0.46887048
118CHEK20.46735564
119HCK0.45791622
120PIK3CA0.45577118
121PRKACA0.45172747
122NEK90.44213410
123CSNK1A1L0.44198039
124FER0.43474108
125CAMKK10.42962703
126ZAP700.42687576
127PBK0.42620318
128TAOK30.42520856
129PHKG20.42519121
130PHKG10.42519121
131PRKCG0.42477163
132TAOK20.42012601
133BRSK10.41430093
134PRKCQ0.41191754
135TNK20.40900563
136PLK40.39401373
137CSNK1A10.39075040
138MARK30.37668716
139BRAF0.36664964
140KDR0.36508480
141MELK0.36372044
142PRKAA10.35511441
143PKN10.34764635
144MAPK40.34735113
145PLK30.34665098
146ATR0.33997769
147MAP3K130.33178786
148MAPK30.32414065
149ATM0.32357396
150WNK30.32056941
151PRKCD0.30980147
152CSNK1D0.30398807
153CDC70.29806883
154PIM20.29702979
155ERBB40.28948968
156FGFR30.28902842
157JAK20.28531064
158CAMK10.28361556
159RPS6KA60.28342429
160PDK20.28261315

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82509376
2Primary immunodeficiency_Homo sapiens_hsa053402.81870221
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39360284
4Fanconi anemia pathway_Homo sapiens_hsa034602.39038747
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.37414663
6Steroid biosynthesis_Homo sapiens_hsa001002.36251848
7Butanoate metabolism_Homo sapiens_hsa006502.23604327
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23117507
9Oxidative phosphorylation_Homo sapiens_hsa001902.20355045
10Selenocompound metabolism_Homo sapiens_hsa004502.19839611
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.19033262
12Other glycan degradation_Homo sapiens_hsa005112.19011864
13Linoleic acid metabolism_Homo sapiens_hsa005912.18832661
14Asthma_Homo sapiens_hsa053102.13145073
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02764215
16Autoimmune thyroid disease_Homo sapiens_hsa053202.02604903
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.96896863
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96119008
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94906701
20Nicotine addiction_Homo sapiens_hsa050331.93240960
21Tryptophan metabolism_Homo sapiens_hsa003801.86846630
22Homologous recombination_Homo sapiens_hsa034401.85078227
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.84236399
24RNA polymerase_Homo sapiens_hsa030201.83913493
25Rheumatoid arthritis_Homo sapiens_hsa053231.78663836
26Nitrogen metabolism_Homo sapiens_hsa009101.73833528
27Parkinsons disease_Homo sapiens_hsa050121.73123076
28Propanoate metabolism_Homo sapiens_hsa006401.72750127
29Allograft rejection_Homo sapiens_hsa053301.63961163
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.61640306
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.58111805
32Regulation of autophagy_Homo sapiens_hsa041401.53837319
33N-Glycan biosynthesis_Homo sapiens_hsa005101.53577600
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.53282278
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52466083
36Graft-versus-host disease_Homo sapiens_hsa053321.52241136
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46821125
38Collecting duct acid secretion_Homo sapiens_hsa049661.44083262
39Measles_Homo sapiens_hsa051621.43018376
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41495646
41Caffeine metabolism_Homo sapiens_hsa002321.41290941
42Phagosome_Homo sapiens_hsa041451.38787274
43Base excision repair_Homo sapiens_hsa034101.37821401
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36001339
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34007974
46Hematopoietic cell lineage_Homo sapiens_hsa046401.28868301
47Malaria_Homo sapiens_hsa051441.28236099
48Huntingtons disease_Homo sapiens_hsa050161.27514950
49Non-homologous end-joining_Homo sapiens_hsa034501.21618475
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20700185
51Sphingolipid metabolism_Homo sapiens_hsa006001.17876436
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.17203267
53Fatty acid elongation_Homo sapiens_hsa000621.15244443
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13957456
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09185633
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08908157
57Protein export_Homo sapiens_hsa030601.08291898
58Vibrio cholerae infection_Homo sapiens_hsa051101.07496017
59Alzheimers disease_Homo sapiens_hsa050101.07012669
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06614714
61One carbon pool by folate_Homo sapiens_hsa006701.05692935
62Cardiac muscle contraction_Homo sapiens_hsa042601.04988182
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04699006
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04194732
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03965562
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03594248
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02545840
68Chemical carcinogenesis_Homo sapiens_hsa052041.01403375
69GABAergic synapse_Homo sapiens_hsa047271.01343837
70Type I diabetes mellitus_Homo sapiens_hsa049400.99502798
71Legionellosis_Homo sapiens_hsa051340.98540551
72Basal transcription factors_Homo sapiens_hsa030220.98102924
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96970229
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96290866
75African trypanosomiasis_Homo sapiens_hsa051430.96176267
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95559783
77Ether lipid metabolism_Homo sapiens_hsa005650.93198454
78Staphylococcus aureus infection_Homo sapiens_hsa051500.92105378
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.91910483
80Arachidonic acid metabolism_Homo sapiens_hsa005900.91608458
81Antigen processing and presentation_Homo sapiens_hsa046120.91415911
82Serotonergic synapse_Homo sapiens_hsa047260.87744452
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87666219
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86765595
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.85284208
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83619668
87Nucleotide excision repair_Homo sapiens_hsa034200.82615914
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.82352895
89Circadian rhythm_Homo sapiens_hsa047100.82261573
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80618991
91Taste transduction_Homo sapiens_hsa047420.80519964
92Lysosome_Homo sapiens_hsa041420.79848520
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79776307
94Leishmaniasis_Homo sapiens_hsa051400.79532806
95Synaptic vesicle cycle_Homo sapiens_hsa047210.78822773
96Vitamin digestion and absorption_Homo sapiens_hsa049770.78792171
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78647299
98Morphine addiction_Homo sapiens_hsa050320.78072132
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77633014
100ABC transporters_Homo sapiens_hsa020100.77473240
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75633652
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75080433
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73935403
104Peroxisome_Homo sapiens_hsa041460.71855184
105Dopaminergic synapse_Homo sapiens_hsa047280.69693727
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.69003335
107Herpes simplex infection_Homo sapiens_hsa051680.68116229
108beta-Alanine metabolism_Homo sapiens_hsa004100.66120454
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66104952
110Proteasome_Homo sapiens_hsa030500.64116386
111Tuberculosis_Homo sapiens_hsa051520.63770590
112Insulin secretion_Homo sapiens_hsa049110.62582545
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62101710
114Purine metabolism_Homo sapiens_hsa002300.59511418
115Sulfur metabolism_Homo sapiens_hsa009200.58821622
116Mismatch repair_Homo sapiens_hsa034300.58510896
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57129348
118Cholinergic synapse_Homo sapiens_hsa047250.56414525
119Osteoclast differentiation_Homo sapiens_hsa043800.56205693
120Hepatitis B_Homo sapiens_hsa051610.54524726
121Histidine metabolism_Homo sapiens_hsa003400.54298190
122Influenza A_Homo sapiens_hsa051640.53738965
123Long-term depression_Homo sapiens_hsa047300.53477233
124Cocaine addiction_Homo sapiens_hsa050300.52972620
125RNA transport_Homo sapiens_hsa030130.52541997
126Circadian entrainment_Homo sapiens_hsa047130.50562255
127Retinol metabolism_Homo sapiens_hsa008300.50294361
128Renin-angiotensin system_Homo sapiens_hsa046140.49522978
129Sulfur relay system_Homo sapiens_hsa041220.48831166
130Glutamatergic synapse_Homo sapiens_hsa047240.48314138
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.47909131
132Arginine and proline metabolism_Homo sapiens_hsa003300.46795522
133Salivary secretion_Homo sapiens_hsa049700.46595849
134Olfactory transduction_Homo sapiens_hsa047400.46084533
135Pyrimidine metabolism_Homo sapiens_hsa002400.45790309
136RNA degradation_Homo sapiens_hsa030180.45781902
137Ovarian steroidogenesis_Homo sapiens_hsa049130.45599306
138Pyruvate metabolism_Homo sapiens_hsa006200.44056026
139Calcium signaling pathway_Homo sapiens_hsa040200.43815119
140Metabolic pathways_Homo sapiens_hsa011000.43567631
141DNA replication_Homo sapiens_hsa030300.41967366
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41774589
143Chemokine signaling pathway_Homo sapiens_hsa040620.41367158
144Melanoma_Homo sapiens_hsa052180.40677973
145Hepatitis C_Homo sapiens_hsa051600.40153927
146Glycerolipid metabolism_Homo sapiens_hsa005610.40049402
147Fatty acid metabolism_Homo sapiens_hsa012120.39600165
148TNF signaling pathway_Homo sapiens_hsa046680.39147338
149T cell receptor signaling pathway_Homo sapiens_hsa046600.38016190
150B cell receptor signaling pathway_Homo sapiens_hsa046620.35076448
151Lysine degradation_Homo sapiens_hsa003100.33751734
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32443502
153Fatty acid biosynthesis_Homo sapiens_hsa000610.32278070
154Oxytocin signaling pathway_Homo sapiens_hsa049210.31073435
155Amphetamine addiction_Homo sapiens_hsa050310.30859692

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