TMEM243

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.09432482
2cullin deneddylation (GO:0010388)4.87982659
3indole-containing compound catabolic process (GO:0042436)4.44574610
4indolalkylamine catabolic process (GO:0046218)4.44574610
5tryptophan catabolic process (GO:0006569)4.44574610
6regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.42387658
7protein deneddylation (GO:0000338)4.40527456
8aromatic amino acid family catabolic process (GO:0009074)4.22054238
9maturation of SSU-rRNA (GO:0030490)4.16989610
10L-phenylalanine catabolic process (GO:0006559)3.96766142
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.96766142
12tryptophan metabolic process (GO:0006568)3.96108827
13antigen processing and presentation of endogenous antigen (GO:0019883)3.90092711
14negative T cell selection (GO:0043383)3.85472626
15amine catabolic process (GO:0009310)3.81807964
16cellular biogenic amine catabolic process (GO:0042402)3.81807964
17NAD biosynthetic process (GO:0009435)3.75895942
18L-phenylalanine metabolic process (GO:0006558)3.69737626
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69737626
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69432362
21negative thymic T cell selection (GO:0045060)3.61381797
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58389108
23positive regulation of gamma-delta T cell activation (GO:0046645)3.47928556
24presynaptic membrane organization (GO:0097090)3.47464287
25T cell migration (GO:0072678)3.44157639
26presynaptic membrane assembly (GO:0097105)3.40931497
27cellular response to interleukin-15 (GO:0071350)3.34693495
28negative regulation of cell killing (GO:0031342)3.28540546
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28540546
30regulation of isotype switching to IgG isotypes (GO:0048302)3.27979487
31positive regulation of alpha-beta T cell proliferation (GO:0046641)3.27924790
32regulation of T cell receptor signaling pathway (GO:0050856)3.27515487
33urea metabolic process (GO:0019627)3.26012197
34urea cycle (GO:0000050)3.26012197
35cellular response to exogenous dsRNA (GO:0071360)3.25209889
36regulation of regulatory T cell differentiation (GO:0045589)3.24351166
37regulation of alpha-beta T cell proliferation (GO:0046640)3.22475555
38surfactant homeostasis (GO:0043129)3.19645588
39bile acid biosynthetic process (GO:0006699)3.18962101
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16812934
41B cell receptor signaling pathway (GO:0050853)3.16362141
42kynurenine metabolic process (GO:0070189)3.15160857
43positive T cell selection (GO:0043368)3.14328521
44regulation of chronic inflammatory response (GO:0002676)3.12431087
45nitrogen cycle metabolic process (GO:0071941)3.11470332
46viral transcription (GO:0019083)3.07303898
47tolerance induction (GO:0002507)3.07018564
48indolalkylamine metabolic process (GO:0006586)3.04688062
49regulation of activation of Janus kinase activity (GO:0010533)3.03437071
50immunoglobulin mediated immune response (GO:0016064)3.03093206
51positive regulation of cellular amine metabolic process (GO:0033240)3.00754008
52B cell mediated immunity (GO:0019724)2.98772077
53nicotinamide nucleotide biosynthetic process (GO:0019359)2.97327040
54pyridine nucleotide biosynthetic process (GO:0019363)2.97327040
55translational termination (GO:0006415)2.97322810
56response to peptidoglycan (GO:0032494)2.97218880
57positive regulation of natural killer cell mediated immunity (GO:0002717)2.96488203
58aromatic amino acid family metabolic process (GO:0009072)2.96447521
59mast cell activation (GO:0045576)2.94659721
60regulation of natural killer cell mediated immunity (GO:0002715)2.94575409
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94575409
62mature B cell differentiation (GO:0002335)2.92269022
63positive regulation of interleukin-17 production (GO:0032740)2.91926201
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90731171
65lymphocyte costimulation (GO:0031294)2.88842426
66positive regulation of isotype switching (GO:0045830)2.88601440
67neutrophil activation involved in immune response (GO:0002283)2.88096029
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87856428
69T cell costimulation (GO:0031295)2.87077846
70positive regulation of DNA recombination (GO:0045911)2.86441896
71positive regulation of interleukin-2 production (GO:0032743)2.86386443
72positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.86350942
73cytidine deamination (GO:0009972)2.86051714
74cytidine metabolic process (GO:0046087)2.86051714
75cytidine catabolic process (GO:0006216)2.86051714
76antigen receptor-mediated signaling pathway (GO:0050851)2.85569004
77cotranslational protein targeting to membrane (GO:0006613)2.85006189
78protein targeting to ER (GO:0045047)2.83906787
79triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79536531
80positive regulation of cellular amide metabolic process (GO:0034250)2.78820808
81aldehyde catabolic process (GO:0046185)2.78215470
82response to interleukin-15 (GO:0070672)2.77406951
83CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77099783
84morphogenesis of an endothelium (GO:0003159)2.76734388
85endothelial tube morphogenesis (GO:0061154)2.76734388
86negative regulation of B cell proliferation (GO:0030889)2.76200149
87positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.75827076
88T cell selection (GO:0045058)2.75671464
89complement activation, alternative pathway (GO:0006957)2.75002578
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74241855
91negative regulation of lipase activity (GO:0060192)2.73688930
92positive regulation of B cell mediated immunity (GO:0002714)2.73611251
93positive regulation of immunoglobulin mediated immune response (GO:0002891)2.73611251
94superoxide anion generation (GO:0042554)2.73587701
95pyrimidine ribonucleoside catabolic process (GO:0046133)2.73290978
96high-density lipoprotein particle remodeling (GO:0034375)2.72672870
97regulation of cholesterol esterification (GO:0010872)2.72357418
98positive regulation of activated T cell proliferation (GO:0042104)2.71798249
99positive thymic T cell selection (GO:0045059)2.70250600
100establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70226854
101translational elongation (GO:0006414)2.69598038
102NIK/NF-kappaB signaling (GO:0038061)2.68526568
103protein localization to endoplasmic reticulum (GO:0070972)2.67729602
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67594898
105negative regulation of phagocytosis (GO:0050765)2.67054488
106phospholipid efflux (GO:0033700)2.66920680
107positive regulation of cell killing (GO:0031343)2.65452225
108blood coagulation, intrinsic pathway (GO:0007597)2.64748385
109multicellular organism reproduction (GO:0032504)2.64352582
110regulation of mitochondrial translation (GO:0070129)2.63455439
111mature B cell differentiation involved in immune response (GO:0002313)2.63005130
112regulation of B cell proliferation (GO:0030888)2.62927710
113bile acid metabolic process (GO:0008206)2.62547150
114fatty acid elongation (GO:0030497)2.62092591
115peptidyl-glutamic acid carboxylation (GO:0017187)2.61983064
116protein carboxylation (GO:0018214)2.61983064
117T cell receptor signaling pathway (GO:0050852)2.61579373
118regulation of B cell differentiation (GO:0045577)2.60578372
119regulation of T cell mediated cytotoxicity (GO:0001914)2.59732895
120production of molecular mediator of immune response (GO:0002440)2.59602833
121ribosomal large subunit biogenesis (GO:0042273)2.59451691
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58749469
123omega-hydroxylase P450 pathway (GO:0097267)2.56449695
124oligosaccharide catabolic process (GO:0009313)2.56366265
125B cell proliferation (GO:0042100)2.55827940
126positive regulation of T cell differentiation in thymus (GO:0033089)2.55473389
127natural killer cell activation involved in immune response (GO:0002323)2.55220982
128tRNA modification (GO:0006400)2.55134290
129cellular glucuronidation (GO:0052695)2.54356071
130imidazole-containing compound metabolic process (GO:0052803)2.54264489
131regulation of cell killing (GO:0031341)2.53318693
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.53313429
133cholesterol efflux (GO:0033344)2.53071572
134ribosomal small subunit assembly (GO:0000028)2.52909070
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51882793
136positive regulation of lymphocyte mediated immunity (GO:0002708)2.51853944
137negative regulation of mast cell activation (GO:0033004)2.51313218
138very-low-density lipoprotein particle assembly (GO:0034379)2.51243955
139positive regulation of immunoglobulin production (GO:0002639)2.51170311
140positive regulation of interferon-gamma production (GO:0032729)2.51149318
141positive regulation of T cell proliferation (GO:0042102)2.50851029
142positive regulation of B cell differentiation (GO:0045579)2.50828427
143G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50532216
144proteasome assembly (GO:0043248)2.50182454
145thymic T cell selection (GO:0045061)2.50038140
146neutrophil activation (GO:0042119)2.49903230
147centriole assembly (GO:0098534)2.46309308
148detection of bacterium (GO:0016045)2.46060465
149interferon-gamma-mediated signaling pathway (GO:0060333)2.45915885
150interferon-gamma production (GO:0032609)2.45890767
151B cell homeostasis (GO:0001782)2.45209655
152fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45196725
153positive regulation of humoral immune response (GO:0002922)2.44720286
154drug transmembrane transport (GO:0006855)2.44448669
155detection of other organism (GO:0098543)2.44380482
156positive regulation of T cell apoptotic process (GO:0070234)2.44062563
157dendritic cell chemotaxis (GO:0002407)2.44047905
158regulation of triglyceride catabolic process (GO:0010896)2.43776438
159regulation of protein activation cascade (GO:2000257)2.43675146
160response to type I interferon (GO:0034340)2.42567883
161regulation of fibrinolysis (GO:0051917)2.42448681
162chemical homeostasis within a tissue (GO:0048875)2.42196366
163uronic acid metabolic process (GO:0006063)2.42040985
164glucuronate metabolic process (GO:0019585)2.42040985
165protein activation cascade (GO:0072376)2.39204625
166complement activation, classical pathway (GO:0006958)2.38856745
167low-density lipoprotein particle remodeling (GO:0034374)2.38553378
168positive regulation of toll-like receptor signaling pathway (GO:0034123)2.38254009
169germinal center formation (GO:0002467)2.37868269
170androgen biosynthetic process (GO:0006702)2.36795260
171cysteine metabolic process (GO:0006534)2.36053800
172DNA deamination (GO:0045006)2.34807653
173response to nitrosative stress (GO:0051409)2.34652438
174regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34185874
175tyrosine metabolic process (GO:0006570)2.34155067
176positive regulation of defense response to virus by host (GO:0002230)2.33692687
177amyloid precursor protein catabolic process (GO:0042987)2.32485885
178homocysteine metabolic process (GO:0050667)2.32242019
179protein-lipid complex remodeling (GO:0034368)2.32164956
180macromolecular complex remodeling (GO:0034367)2.32164956
181plasma lipoprotein particle remodeling (GO:0034369)2.32164956
182regulation of B cell receptor signaling pathway (GO:0050855)2.31258297
183coenzyme catabolic process (GO:0009109)2.29693461
184cofactor catabolic process (GO:0051187)2.29131013
185serine family amino acid catabolic process (GO:0009071)2.28523991
186bile acid and bile salt transport (GO:0015721)2.27646774
187reverse cholesterol transport (GO:0043691)2.26998379
188granulocyte activation (GO:0036230)2.26884158
189triglyceride homeostasis (GO:0070328)2.26331482
190acylglycerol homeostasis (GO:0055090)2.26331482
191glyoxylate metabolic process (GO:0046487)2.25992167
192mannosylation (GO:0097502)2.25911324
193centriole replication (GO:0007099)2.25652945
194response to hyperoxia (GO:0055093)2.25570603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.86332432
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.38988286
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82703609
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.51648332
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.27265369
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.27232015
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90558967
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.89116045
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84974049
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82816546
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.81244528
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.76895618
13MYB_26560356_Chip-Seq_TH2_Human2.74721098
14VDR_23849224_ChIP-Seq_CD4+_Human2.74108258
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.73463918
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67399689
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.67388316
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65611575
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62777929
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52606092
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.37187883
22SUZ12_27294783_Chip-Seq_NPCs_Mouse2.33129068
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30156142
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.20640935
25FOXP3_21729870_ChIP-Seq_TREG_Human2.19731909
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19248357
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18599797
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18527309
29ELK1_19687146_ChIP-ChIP_HELA_Human2.16850624
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11778483
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.11070944
32PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10270365
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08556219
34EZH2_27294783_Chip-Seq_NPCs_Mouse2.07950628
35LXR_22158963_ChIP-Seq_LIVER_Mouse2.07784013
36IRF8_27001747_Chip-Seq_BMDM_Mouse2.06139304
37MYB_26560356_Chip-Seq_TH1_Human2.06021374
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05977985
39ETS1_20019798_ChIP-Seq_JURKAT_Human2.02859674
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02256722
41PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01642267
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.97740139
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95670036
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87472885
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.81427814
46RUNX1_27457419_Chip-Seq_LIVER_Mouse1.81138881
47E2F7_22180533_ChIP-Seq_HELA_Human1.80991560
48GATA1_22025678_ChIP-Seq_K562_Human1.80547794
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79740201
50TAF15_26573619_Chip-Seq_HEK293_Human1.79434012
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79357960
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.76895453
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75500199
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75176943
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74571510
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74078975
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74009563
58GATA3_27048872_Chip-Seq_THYMUS_Human1.73385598
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.71004352
60P53_22387025_ChIP-Seq_ESCs_Mouse1.70205735
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68429851
62P300_18555785_Chip-Seq_ESCs_Mouse1.65784971
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.65696554
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.64971551
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64189685
66CIITA_25753668_ChIP-Seq_RAJI_Human1.61998153
67GATA3_26560356_Chip-Seq_TH2_Human1.61125584
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60518361
69SMAD1_18555785_Chip-Seq_ESCs_Mouse1.58877010
70PU1_27457419_Chip-Seq_LIVER_Mouse1.58575416
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58310244
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.55205782
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.54682877
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.54532728
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53715312
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52828208
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.52544251
78ZFX_18555785_Chip-Seq_ESCs_Mouse1.51989834
79ESRRB_18555785_Chip-Seq_ESCs_Mouse1.51442226
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50920991
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.48436199
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.48190504
83KLF4_18555785_Chip-Seq_ESCs_Mouse1.46020075
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44989167
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44335651
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43947436
87IRF1_19129219_ChIP-ChIP_H3396_Human1.42654331
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41532270
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41408850
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.40421950
91CTCF_18555785_Chip-Seq_ESCs_Mouse1.40272384
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39651409
93DCP1A_22483619_ChIP-Seq_HELA_Human1.39007689
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.38009080
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.36968744
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34032160
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33154918
98GBX2_23144817_ChIP-Seq_PC3_Human1.32305937
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29772686
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28676128
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.27378281
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.27063591
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26472898
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.25006899
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23837084
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23440832
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22121816
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20747958
109MYC_18940864_ChIP-ChIP_HL60_Human1.20401040
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20113699
111GABP_19822575_ChIP-Seq_HepG2_Human1.18878863
112MAF_26560356_Chip-Seq_TH1_Human1.18715654
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18454541
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17549810
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12988628
116NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12766430
117ZNF274_21170338_ChIP-Seq_K562_Hela1.10754783
118STAT1_17558387_ChIP-Seq_HELA_Human1.10337821
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10309410
120RUNX_20019798_ChIP-Seq_JUKART_Human1.10142463
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10125509
122HTT_18923047_ChIP-ChIP_STHdh_Human1.09701145
123MYC_22102868_ChIP-Seq_BL_Human1.08736145
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07999474
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07645235
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07112120
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06346706
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05187636
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04856652
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04336645
131P300_19829295_ChIP-Seq_ESCs_Human1.02535498
132IGF1R_20145208_ChIP-Seq_DFB_Human1.02480821
133UTX_26944678_Chip-Seq_JUKART_Human1.02060474
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00527093
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00052095
136MAF_26560356_Chip-Seq_TH2_Human0.99794209
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98539727
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98361707
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98186244
140SPI1_23547873_ChIP-Seq_NB4_Human0.98007858
141VDR_22108803_ChIP-Seq_LS180_Human0.96079139
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94915234
143E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94508784
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92895801
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92292929
146SCL_19346495_ChIP-Seq_HPC-7_Human0.92052108
147KDM2B_26808549_Chip-Seq_REH_Human0.91958230
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91094808
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90783528
150SMRT_27268052_Chip-Seq_Bcells_Human0.89224607
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88923960
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88821722
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88580322
154TTF2_22483619_ChIP-Seq_HELA_Human0.88177259
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.86512750
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.86444259
157TFEB_21752829_ChIP-Seq_HELA_Human0.86294569
158PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85903384
159EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85222882
160FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85002349
161GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84548920
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.83586159
163ER_23166858_ChIP-Seq_MCF-7_Human0.83281373
164NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82031162
165PU_27001747_Chip-Seq_BMDM_Mouse0.81447931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.33418233
2MP0005360_urolithiasis3.18508748
3MP0005085_abnormal_gallbladder_physiolo3.15089440
4MP0009333_abnormal_splenocyte_physiolog3.11217315
5MP0005365_abnormal_bile_salt2.88428249
6MP0001835_abnormal_antigen_presentation2.79472078
7MP0004381_abnormal_hair_follicle2.74975789
8MP0008875_abnormal_xenobiotic_pharmacok2.73397312
9MP0003724_increased_susceptibility_to2.59803188
10MP0004782_abnormal_surfactant_physiolog2.59121621
11MP0002138_abnormal_hepatobiliary_system2.48400961
12MP0009785_altered_susceptibility_to2.32986393
13MP0002166_altered_tumor_susceptibility2.24520624
14MP0001873_stomach_inflammation2.22442995
15MP0005671_abnormal_response_to2.17020938
16MP0006292_abnormal_olfactory_placode2.14842819
17MP0001790_abnormal_immune_system2.09497269
18MP0005387_immune_system_phenotype2.09497269
19MP0003136_yellow_coat_color2.08042945
20MP0003436_decreased_susceptibility_to2.03922294
21MP0002148_abnormal_hypersensitivity_rea1.99501234
22MP0001800_abnormal_humoral_immune1.92258941
23MP0003806_abnormal_nucleotide_metabolis1.92161087
24MP0002876_abnormal_thyroid_physiology1.85712076
25MP0005000_abnormal_immune_tolerance1.85373208
26MP0000566_synostosis1.84609184
27MP0002277_abnormal_respiratory_mucosa1.84045612
28MP0005025_abnormal_response_to1.82851693
29MP0003252_abnormal_bile_duct1.81602112
30MP0009764_decreased_sensitivity_to1.80676800
31MP0002132_abnormal_respiratory_system1.79786942
32MP0000685_abnormal_immune_system1.77066074
33MP0000516_abnormal_urinary_system1.76898954
34MP0005367_renal/urinary_system_phenotyp1.76898954
35MP0005075_abnormal_melanosome_morpholog1.76019189
36MP0010307_abnormal_tumor_latency1.69790821
37MP0002419_abnormal_innate_immunity1.69493530
38MP0000703_abnormal_thymus_morphology1.68501293
39MP0009379_abnormal_foot_pigmentation1.68107340
40MP0002723_abnormal_immune_serum1.67846854
41MP0008995_early_reproductive_senescence1.64659928
42MP0002452_abnormal_antigen_presenting1.63821351
43MP0003011_delayed_dark_adaptation1.63699042
44MP0010094_abnormal_chromosome_stability1.54604299
45MP0005310_abnormal_salivary_gland1.53941437
46MP0005409_darkened_coat_color1.50864310
47MP0001188_hyperpigmentation1.49639423
48MP0003195_calcinosis1.49616703
49MP0003693_abnormal_embryo_hatching1.49102617
50MP0003868_abnormal_feces_composition1.46791778
51MP0003718_maternal_effect1.44064210
52MP0001764_abnormal_homeostasis1.43223274
53MP0009697_abnormal_copulation1.41917482
54MP0000465_gastrointestinal_hemorrhage1.41301049
55MP0002420_abnormal_adaptive_immunity1.39524661
56MP0001819_abnormal_immune_cell1.39319781
57MP0000015_abnormal_ear_pigmentation1.37489659
58MP0008260_abnormal_autophagy1.35713923
59MP0003300_gastrointestinal_ulcer1.35378866
60MP0002163_abnormal_gland_morphology1.33916946
61MP0005332_abnormal_amino_acid1.33843611
62MP0005408_hypopigmentation1.33552494
63MP0008469_abnormal_protein_level1.32261865
64MP0004019_abnormal_vitamin_homeostasis1.31803932
65MP0001853_heart_inflammation1.30961326
66MP0003763_abnormal_thymus_physiology1.28732326
67MP0005174_abnormal_tail_pigmentation1.27315829
68MP0002019_abnormal_tumor_incidence1.26120091
69MP0010329_abnormal_lipoprotein_level1.25628450
70MP0003191_abnormal_cellular_cholesterol1.22158836
71MP0000858_altered_metastatic_potential1.21042197
72MP0003866_abnormal_defecation1.19754086
73MP0005451_abnormal_body_composition1.19425842
74MP0001986_abnormal_taste_sensitivity1.16512803
75MP0006082_CNS_inflammation1.16295523
76MP0001845_abnormal_inflammatory_respons1.15169973
77MP0003186_abnormal_redox_activity1.13931587
78MP0005647_abnormal_sex_gland1.11016656
79MP0008058_abnormal_DNA_repair1.10526360
80MP0000716_abnormal_immune_system1.07810394
81MP0001666_abnormal_nutrient_absorption1.06099770
82MP0002009_preneoplasia1.05592470
83MP0005464_abnormal_platelet_physiology1.03827026
84MP0000490_abnormal_crypts_of1.03363484
85MP0009765_abnormal_xenobiotic_induced1.01825244
86MP0009840_abnormal_foam_cell1.01792634
87MP0009763_increased_sensitivity_to1.00575452
88MP0002095_abnormal_skin_pigmentation1.00525788
89MP0003077_abnormal_cell_cycle0.98258184
90MP0002405_respiratory_system_inflammati0.98052870
91MP0000609_abnormal_liver_physiology0.97882671
92MP0000689_abnormal_spleen_morphology0.97184332
93MP0005389_reproductive_system_phenotype0.97135030
94MP0005083_abnormal_biliary_tract0.96312280
95MP0001348_abnormal_lacrimal_gland0.95679320
96MP0002118_abnormal_lipid_homeostasis0.91508534
97MP0000681_abnormal_thyroid_gland0.90503047
98MP0008057_abnormal_DNA_replication0.89132724
99MP0003303_peritoneal_inflammation0.86895307
100MP0002398_abnormal_bone_marrow0.86437848
101MP0010155_abnormal_intestine_physiology0.86321655
102MP0004947_skin_inflammation0.83936650
103MP0003448_altered_tumor_morphology0.83042812
104MP0001533_abnormal_skeleton_physiology0.81441491
105MP0002160_abnormal_reproductive_system0.80543166
106MP0005084_abnormal_gallbladder_morpholo0.80494078
107MP0006072_abnormal_retinal_apoptosis0.78268708
108MP0005379_endocrine/exocrine_gland_phen0.78063533
109MP0003786_premature_aging0.77744890
110MP0002429_abnormal_blood_cell0.76987541
111MP0001727_abnormal_embryo_implantation0.76094115
112MP0002722_abnormal_immune_system0.74930591
113MP0000372_irregular_coat_pigmentation0.73543192
114MP0005319_abnormal_enzyme/_coenzyme0.72053280
115MP0005171_absent_coat_pigmentation0.72011680
116MP0003567_abnormal_fetal_cardiomyocyte0.71146036
117MP0005395_other_phenotype0.70806947
118MP0008873_increased_physiological_sensi0.70375417
119MP0005551_abnormal_eye_electrophysiolog0.70366270
120MP0000613_abnormal_salivary_gland0.70144287
121MP0008872_abnormal_physiological_respon0.69556358
122MP0000538_abnormal_urinary_bladder0.69492970
123MP0002136_abnormal_kidney_physiology0.68028520
124MP0002254_reproductive_system_inflammat0.67319382
125MP0002098_abnormal_vibrissa_morphology0.66919934
126MP0005670_abnormal_white_adipose0.66735279
127MP0005584_abnormal_enzyme/coenzyme_acti0.65840928
128MP0009643_abnormal_urine_homeostasis0.65640381
129MP0001919_abnormal_reproductive_system0.64814206
130MP0000371_diluted_coat_color0.64067199
131MP0005164_abnormal_response_to0.62363768
132MP0002006_tumorigenesis0.61339111
133MP0002933_joint_inflammation0.60350699
134MP0000604_amyloidosis0.58729441
135MP0001119_abnormal_female_reproductive0.58344417
136MP0000343_altered_response_to0.57991475
137MP0000569_abnormal_digit_pigmentation0.57925290
138MP0006054_spinal_hemorrhage0.57612465
139MP0003111_abnormal_nucleus_morphology0.57512683
140MP0002693_abnormal_pancreas_physiology0.57421767
141MP0000313_abnormal_cell_death0.57110167
142MP0001663_abnormal_digestive_system0.56131129
143MP0004957_abnormal_blastocyst_morpholog0.55742701

Predicted human phenotypes

RankGene SetZ-score
1Inflammation of the large intestine (HP:0002037)4.47984407
2Prolonged partial thromboplastin time (HP:0003645)4.27205268
3Panhypogammaglobulinemia (HP:0003139)4.15649397
4Gastrointestinal inflammation (HP:0004386)4.12872140
5IgG deficiency (HP:0004315)4.12024565
6Joint hemorrhage (HP:0005261)4.02909596
7B lymphocytopenia (HP:0010976)3.91536160
8Recurrent bronchitis (HP:0002837)3.79264038
9Abnormality of B cell number (HP:0010975)3.77921312
10T lymphocytopenia (HP:0005403)3.63613853
11Abnormality of T cell number (HP:0011839)3.58166017
12Intrahepatic cholestasis (HP:0001406)3.56205612
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51059034
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.46657326
15Recurrent viral infections (HP:0004429)3.46634450
16Abnormality of cells of the lymphoid lineage (HP:0012140)3.37315256
17Abnormality of T cells (HP:0002843)3.35570865
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.29507192
19Combined immunodeficiency (HP:0005387)3.15036893
20Reduced antithrombin III activity (HP:0001976)3.10934196
21Recurrent gram-negative bacterial infections (HP:0005420)3.10529800
22Pulmonary infiltrates (HP:0002113)2.99326321
23Abnormality of T cell physiology (HP:0011840)2.97272450
24Thyroid-stimulating hormone excess (HP:0002925)2.94135117
25Thyroiditis (HP:0100646)2.89209588
26Lymphoma (HP:0002665)2.84687868
27Abnormality of pyrimidine metabolism (HP:0004353)2.83880446
28Abnormality of methionine metabolism (HP:0010901)2.83679066
29Recurrent bacterial skin infections (HP:0005406)2.78513073
30Epidermoid cyst (HP:0200040)2.74277728
31Recurrent abscess formation (HP:0002722)2.72960355
32Chronic otitis media (HP:0000389)2.72096479
33Renal cortical cysts (HP:0000803)2.71344451
34Autoimmune hemolytic anemia (HP:0001890)2.70337553
35Chronic sinusitis (HP:0011109)2.68413595
36IgA deficiency (HP:0002720)2.66440125
37Recurrent sinusitis (HP:0011108)2.61768910
38Type I transferrin isoform profile (HP:0003642)2.56001504
39Hypoproteinemia (HP:0003075)2.51412767
40Hyperlipoproteinemia (HP:0010980)2.48945733
41Eczematoid dermatitis (HP:0000976)2.47627141
42Aplastic anemia (HP:0001915)2.46960990
43Bronchitis (HP:0012387)2.44769081
44Parakeratosis (HP:0001036)2.43282488
45Abnormality of eosinophils (HP:0001879)2.42862921
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42654555
47Colon cancer (HP:0003003)2.42078929
48Complement deficiency (HP:0004431)2.41432626
49Prostate neoplasm (HP:0100787)2.39610882
50Eosinophilia (HP:0001880)2.38956223
51Papilloma (HP:0012740)2.38795217
52Verrucae (HP:0200043)2.38795217
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38405770
54Stomatitis (HP:0010280)2.38196391
55Retrobulbar optic neuritis (HP:0100654)2.38163596
56Optic neuritis (HP:0100653)2.38163596
57Meningitis (HP:0001287)2.34419843
58Vasculitis (HP:0002633)2.33742002
59Tubulointerstitial nephritis (HP:0001970)2.30568659
60Abnormality of macrophages (HP:0004311)2.30229589
61Hypoplasia of the thymus (HP:0000778)2.30153992
62Recurrent pneumonia (HP:0006532)2.29386759
63Abnormality of the common coagulation pathway (HP:0010990)2.29218752
64Interstitial pulmonary disease (HP:0006530)2.28789722
65Conjugated hyperbilirubinemia (HP:0002908)2.27236285
66Acute necrotizing encephalopathy (HP:0006965)2.26381935
67Mediastinal lymphadenopathy (HP:0100721)2.25994268
68Hypobetalipoproteinemia (HP:0003563)2.24248376
69Emphysema (HP:0002097)2.23242718
70Fat malabsorption (HP:0002630)2.22065749
71Agammaglobulinemia (HP:0004432)2.21314067
72Mitochondrial inheritance (HP:0001427)2.18567951
73Neutropenia (HP:0001875)2.18476017
74Recurrent skin infections (HP:0001581)2.18211150
75Restrictive lung disease (HP:0002091)2.15466988
76Stomach cancer (HP:0012126)2.14703526
77Leukocytosis (HP:0001974)2.13250999
78Gingival bleeding (HP:0000225)2.12521852
79Chromsome breakage (HP:0040012)2.11984994
80Xanthomatosis (HP:0000991)2.11892985
81Leukopenia (HP:0001882)2.11033053
82Exertional dyspnea (HP:0002875)2.09799553
83Glomerulonephritis (HP:0000099)2.07792311
84Microcytic anemia (HP:0001935)2.06587197
85Orchitis (HP:0100796)2.06200999
86Prolonged neonatal jaundice (HP:0006579)2.06137625
87Alveolar cell carcinoma (HP:0006519)2.05716163
88Abnormality of the axillary hair (HP:0100134)2.05620128
89Abnormality of secondary sexual hair (HP:0009888)2.05620128
90Deep venous thrombosis (HP:0002625)2.04834039
91Congenital, generalized hypertrichosis (HP:0004540)2.04675157
92Increased CSF lactate (HP:0002490)2.04456139
93Encephalitis (HP:0002383)2.04230340
94Hepatocellular necrosis (HP:0001404)2.03420054
95Abnormal mitochondria in muscle tissue (HP:0008316)2.01807692
96Azoospermia (HP:0000027)2.01170505
97Steatorrhea (HP:0002570)2.00876277
98Pulmonary fibrosis (HP:0002206)1.99457257
99Decreased central vision (HP:0007663)1.99412404
100Progressive macrocephaly (HP:0004481)1.98780247
101Hemoptysis (HP:0002105)1.97268944
102Abnormality of cells of the erythroid lineage (HP:0012130)1.97243584
103Myositis (HP:0100614)1.95892414
104Abnormality of the pleura (HP:0002103)1.95820887
105Chest pain (HP:0100749)1.95540124
106Methylmalonic aciduria (HP:0012120)1.95483114
107IgM deficiency (HP:0002850)1.94951364
108Pancreatic cysts (HP:0001737)1.93217773
109Colitis (HP:0002583)1.93133512
110Elevated erythrocyte sedimentation rate (HP:0003565)1.92959058
111Obstructive lung disease (HP:0006536)1.92631694
112Chronic obstructive pulmonary disease (HP:0006510)1.92631694
113Abnormal glycosylation (HP:0012345)1.92535878
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92535878
115Abnormal protein N-linked glycosylation (HP:0012347)1.92535878
116Abnormal protein glycosylation (HP:0012346)1.92535878
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.91528436
118Systemic lupus erythematosus (HP:0002725)1.90502214
119Vascular calcification (HP:0004934)1.90448709
120Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90252949
121Granulocytopenia (HP:0001913)1.88726630
122Dry hair (HP:0011359)1.88567775
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88029054
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87751024
125Hypoalbuminemia (HP:0003073)1.87575810
126Abnormal albumin level (HP:0012116)1.87575810
127Methylmalonic acidemia (HP:0002912)1.87050407
128Cleft eyelid (HP:0000625)1.86104453
129Abnormality of complement system (HP:0005339)1.86001930
130Increased IgM level (HP:0003496)1.85145076
131Renal Fanconi syndrome (HP:0001994)1.84857657
132Abnormality of the prostate (HP:0008775)1.83995753
133Recurrent cutaneous fungal infections (HP:0011370)1.83961107
134Chronic mucocutaneous candidiasis (HP:0002728)1.83961107
135Global brain atrophy (HP:0002283)1.82482899
136Gastrointestinal stroma tumor (HP:0100723)1.81725324
1373-Methylglutaconic aciduria (HP:0003535)1.80794168
138Abnormality of male internal genitalia (HP:0000022)1.80776309
139Fair hair (HP:0002286)1.79614599
140Absent/shortened dynein arms (HP:0200106)1.79331616
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.79331616
142Chronic diarrhea (HP:0002028)1.79216890
143Hypochromic anemia (HP:0001931)1.78451161
144Thrombocytosis (HP:0001894)1.77593279
145Neoplasm of the tracheobronchial system (HP:0100552)1.77474623
146Pancytopenia (HP:0001876)1.76631886
147Type 2 muscle fiber atrophy (HP:0003554)1.76621274
148Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75798368
149Recurrent lower respiratory tract infections (HP:0002783)1.74914115
150Abnormality of the renal cortex (HP:0011035)1.73764323
151Osteomalacia (HP:0002749)1.72137035
152Recurrent fungal infections (HP:0002841)1.72016527
153Clubbing of toes (HP:0100760)1.72001479
154Menorrhagia (HP:0000132)1.71331598
155Epistaxis (HP:0000421)1.70904251
156Respiratory distress (HP:0002098)1.69838566
157Lymphopenia (HP:0001888)1.69733550
158Abnormality of nucleobase metabolism (HP:0010932)1.69628187
159Severe combined immunodeficiency (HP:0004430)1.68760194
160Cheilitis (HP:0100825)1.67928172
161Abnormal spermatogenesis (HP:0008669)1.66783501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.53547971
2IRAK43.42831008
3VRK23.30631894
4CASK3.05079648
5STK162.83929773
6MAP3K142.59822766
7IRAK12.57601569
8IRAK22.37835312
9TXK2.19018068
10NLK2.01263479
11MUSK1.96801126
12TNIK1.94056371
13MAP4K21.90424346
14MAP4K11.78506359
15PLK41.76515382
16ZAK1.67820767
17BMPR1B1.63609144
18IKBKE1.63080154
19TEC1.55233691
20IKBKB1.53006239
21MST41.52776440
22PBK1.51331706
23CLK11.49825037
24BLK1.49362697
25PASK1.49010917
26MKNK21.48292169
27EIF2AK31.46221334
28ERN11.41029511
29INSRR1.40469601
30YES11.38806781
31EIF2AK21.36705032
32SRPK11.27262729
33GRK11.24469535
34TAOK31.23028357
35TLK11.19971175
36TESK21.15776714
37CDC71.15384439
38TBK11.15371792
39CDK31.13332800
40BMPR21.12599731
41BCKDK1.10609494
42TYK21.10604114
43BTK1.09470585
44NUAK11.07663185
45GRK71.05972426
46CSF1R1.04668432
47VRK11.04547856
48MAP3K121.03508257
49STK241.00312673
50AKT30.97164260
51SIK30.96654356
52EIF2AK10.96433977
53NEK60.94561285
54KIT0.94423554
55FES0.93412808
56LYN0.92508178
57CAMKK20.91546659
58PRPF4B0.91349920
59GRK60.91082183
60EPHA30.90397462
61BRAF0.87941436
62ZAP700.87845772
63FGFR40.87542084
64TRIM280.86600865
65MKNK10.86331105
66FRK0.85067184
67MAPK150.84686031
68BRSK20.83504015
69PKN10.83150134
70TGFBR20.82274628
71JAK30.82222075
72ERBB40.81190117
73ADRBK20.80442735
74SYK0.79606285
75MAP2K70.77924847
76TAF10.74070239
77ATR0.73982079
78MARK30.73912298
79JAK10.70426236
80WEE10.68919740
81PRKCH0.68824769
82PIM10.68324672
83ACVR1B0.67568947
84CHUK0.65644412
85BUB10.65237546
86PRKCQ0.65101615
87CDK190.64931574
88PIM20.64656790
89CSK0.64429339
90TNK20.61303292
91LCK0.60978481
92CDK80.59210324
93BRD40.59082494
94PRKD20.58204320
95STK40.57510566
96RIPK40.56188182
97ITK0.55731288
98MAP3K130.55360555
99STK38L0.54578334
100KDR0.54515438
101TTK0.54350492
102PIK3CG0.53542089
103CSNK1G10.53232557
104PIK3CA0.52365746
105PRKCI0.52015760
106PINK10.50633688
107AURKB0.50108603
108MAPK70.50078846
109SGK20.50027043
110CAMK2G0.49472940
111NEK90.49343714
112ABL10.48971753
113RPS6KA50.48777386
114TIE10.48227031
115MAP2K20.47841547
116HCK0.47377796
117NME20.46625763
118CDK90.46340042
119ABL20.46202064
120CSNK1A1L0.45650664
121TGFBR10.44983549
122RPS6KA40.44865404
123STK100.43919200
124MST1R0.43337725
125MAPK40.42561321
126OXSR10.42422989
127CHEK10.39242193
128PDK20.38637517
129NEK10.37804617
130PRKCD0.36573851
131CSNK1G30.35822760
132MAPK110.35751417
133GRK50.35251676
134FGR0.34891659
135PLK10.32415965
136CCNB10.32297784
137CDK40.32291578
138CSNK2A20.32208518
139MELK0.31077114

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.19859001
2Ribosome_Homo sapiens_hsa030103.00502797
3Type I diabetes mellitus_Homo sapiens_hsa049402.94693297
4Proteasome_Homo sapiens_hsa030502.47715412
5Antigen processing and presentation_Homo sapiens_hsa046122.31632422
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.26813250
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23743486
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18710221
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18682133
10Histidine metabolism_Homo sapiens_hsa003402.16162853
11Systemic lupus erythematosus_Homo sapiens_hsa053222.11502726
12Retinol metabolism_Homo sapiens_hsa008302.11110737
13Complement and coagulation cascades_Homo sapiens_hsa046102.10206344
14Staphylococcus aureus infection_Homo sapiens_hsa051502.09714135
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07124645
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03283071
17Peroxisome_Homo sapiens_hsa041461.93315942
18Tryptophan metabolism_Homo sapiens_hsa003801.92570631
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.84390960
20Chemical carcinogenesis_Homo sapiens_hsa052041.83928167
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82391024
22beta-Alanine metabolism_Homo sapiens_hsa004101.72578850
23Fatty acid elongation_Homo sapiens_hsa000621.72223569
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.71290190
25Primary immunodeficiency_Homo sapiens_hsa053401.69687885
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67871582
27Viral myocarditis_Homo sapiens_hsa054161.64868218
28Graft-versus-host disease_Homo sapiens_hsa053321.62445745
29Folate biosynthesis_Homo sapiens_hsa007901.59977012
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57571063
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57390696
32Sulfur metabolism_Homo sapiens_hsa009201.55288807
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54551708
34RNA degradation_Homo sapiens_hsa030181.54303668
35Mismatch repair_Homo sapiens_hsa034301.54286233
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.53057426
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.49701236
38Steroid biosynthesis_Homo sapiens_hsa001001.44308493
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43949900
40Vitamin digestion and absorption_Homo sapiens_hsa049771.38984127
41Spliceosome_Homo sapiens_hsa030401.36529510
42ABC transporters_Homo sapiens_hsa020101.32725020
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32617419
44Caffeine metabolism_Homo sapiens_hsa002321.32497286
45Phenylalanine metabolism_Homo sapiens_hsa003601.31638630
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31458293
47Selenocompound metabolism_Homo sapiens_hsa004501.26933793
48Tyrosine metabolism_Homo sapiens_hsa003501.25841266
49Oxidative phosphorylation_Homo sapiens_hsa001901.24668946
50T cell receptor signaling pathway_Homo sapiens_hsa046601.23936982
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22538807
52Homologous recombination_Homo sapiens_hsa034401.21018364
53Allograft rejection_Homo sapiens_hsa053301.19552130
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14850393
55Fanconi anemia pathway_Homo sapiens_hsa034601.14301765
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.13257155
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11246983
58Ether lipid metabolism_Homo sapiens_hsa005651.10320705
59Arginine biosynthesis_Homo sapiens_hsa002201.09244208
60Autoimmune thyroid disease_Homo sapiens_hsa053201.08760983
61Nucleotide excision repair_Homo sapiens_hsa034201.06677011
62Parkinsons disease_Homo sapiens_hsa050121.03403142
63Fatty acid degradation_Homo sapiens_hsa000711.00198155
64Non-homologous end-joining_Homo sapiens_hsa034500.99830828
65Glutathione metabolism_Homo sapiens_hsa004800.99302567
66Protein export_Homo sapiens_hsa030600.99252847
67Epstein-Barr virus infection_Homo sapiens_hsa051690.97318024
68Measles_Homo sapiens_hsa051620.92909648
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92189811
70Hematopoietic cell lineage_Homo sapiens_hsa046400.92051936
71Pyrimidine metabolism_Homo sapiens_hsa002400.91751629
72Arachidonic acid metabolism_Homo sapiens_hsa005900.90275494
73Tuberculosis_Homo sapiens_hsa051520.89798974
74Linoleic acid metabolism_Homo sapiens_hsa005910.87431348
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84937940
76One carbon pool by folate_Homo sapiens_hsa006700.84508048
77Other glycan degradation_Homo sapiens_hsa005110.83344011
78Sphingolipid metabolism_Homo sapiens_hsa006000.82233525
79Osteoclast differentiation_Homo sapiens_hsa043800.81312433
80Phototransduction_Homo sapiens_hsa047440.80349853
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78692091
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77273520
83Propanoate metabolism_Homo sapiens_hsa006400.76252192
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.75402978
85Malaria_Homo sapiens_hsa051440.74887758
86HTLV-I infection_Homo sapiens_hsa051660.74800818
87PPAR signaling pathway_Homo sapiens_hsa033200.74755385
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74689960
89Sulfur relay system_Homo sapiens_hsa041220.74469905
90Vitamin B6 metabolism_Homo sapiens_hsa007500.74383590
91Leishmaniasis_Homo sapiens_hsa051400.73802277
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73195350
93Arginine and proline metabolism_Homo sapiens_hsa003300.72759555
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72719821
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.72287689
96RNA transport_Homo sapiens_hsa030130.72052626
97Toxoplasmosis_Homo sapiens_hsa051450.71630907
98Viral carcinogenesis_Homo sapiens_hsa052030.71034058
99Cell cycle_Homo sapiens_hsa041100.70034444
100Starch and sucrose metabolism_Homo sapiens_hsa005000.68705491
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67652711
102p53 signaling pathway_Homo sapiens_hsa041150.66885272
103Apoptosis_Homo sapiens_hsa042100.66824655
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66634645
105Herpes simplex infection_Homo sapiens_hsa051680.66625141
106Alcoholism_Homo sapiens_hsa050340.65876604
107Pertussis_Homo sapiens_hsa051330.65057511
108Asthma_Homo sapiens_hsa053100.64818246
109Metabolic pathways_Homo sapiens_hsa011000.64734367
110DNA replication_Homo sapiens_hsa030300.63767873
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63405175
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62500621
113Rheumatoid arthritis_Homo sapiens_hsa053230.62455050
114Huntingtons disease_Homo sapiens_hsa050160.60632696
115TNF signaling pathway_Homo sapiens_hsa046680.60111848
116Base excision repair_Homo sapiens_hsa034100.59478668
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58277536
118Basal transcription factors_Homo sapiens_hsa030220.58087304
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55981059
120Regulation of autophagy_Homo sapiens_hsa041400.55799796
121Legionellosis_Homo sapiens_hsa051340.54678841
122Butanoate metabolism_Homo sapiens_hsa006500.53861695
123Shigellosis_Homo sapiens_hsa051310.50709932
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.48449269
125Purine metabolism_Homo sapiens_hsa002300.48073567
126Alzheimers disease_Homo sapiens_hsa050100.47785197
127B cell receptor signaling pathway_Homo sapiens_hsa046620.47704282
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45998929
129Chemokine signaling pathway_Homo sapiens_hsa040620.45872812
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45620773
131RNA polymerase_Homo sapiens_hsa030200.45270773
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44347937
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43631646
134Fatty acid metabolism_Homo sapiens_hsa012120.43302782
135African trypanosomiasis_Homo sapiens_hsa051430.40431919
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39925302
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39895672
138Influenza A_Homo sapiens_hsa051640.37860771
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.35625082
140Hepatitis B_Homo sapiens_hsa051610.31895677
141N-Glycan biosynthesis_Homo sapiens_hsa005100.25012011
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22253751
143Hepatitis C_Homo sapiens_hsa051600.21291318
144Phagosome_Homo sapiens_hsa041450.16717271
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16675167
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16091173
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15942527
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13936576

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