TMEM245

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)3.70438926
2axon ensheathment in central nervous system (GO:0032291)3.70438926
3paraxial mesoderm development (GO:0048339)3.64826845
4histone H3-K4 trimethylation (GO:0080182)3.57103859
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34778114
6negative regulation of translation, ncRNA-mediated (GO:0040033)3.23477373
7regulation of translation, ncRNA-mediated (GO:0045974)3.23477373
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23477373
9cellular response to epinephrine stimulus (GO:0071872)3.20266579
10embryonic foregut morphogenesis (GO:0048617)3.16555481
11retina vasculature morphogenesis in camera-type eye (GO:0061299)3.10523149
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08991109
13glycerophospholipid catabolic process (GO:0046475)3.05709270
14mitotic sister chromatid cohesion (GO:0007064)3.04381506
15regulation of transforming growth factor beta2 production (GO:0032909)3.04368291
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.99695885
17cell communication by electrical coupling (GO:0010644)2.96513374
18response to epinephrine (GO:0071871)2.96219709
19nuclear pore complex assembly (GO:0051292)2.91550421
20desmosome organization (GO:0002934)2.90544311
21cytoplasmic mRNA processing body assembly (GO:0033962)2.89647260
22mitotic chromosome condensation (GO:0007076)2.87558091
23regulation of cardioblast differentiation (GO:0051890)2.86977031
24negative regulation of protein localization to cell surface (GO:2000009)2.84088879
25negative regulation of hormone biosynthetic process (GO:0032353)2.83724308
26regulation of steroid hormone biosynthetic process (GO:0090030)2.81410841
27sarcomere organization (GO:0045214)2.78623098
28positive regulation of cardiac muscle cell differentiation (GO:2000727)2.76855086
29cellular sodium ion homeostasis (GO:0006883)2.76271911
30myelination (GO:0042552)2.76243209
31axon ensheathment (GO:0008366)2.76155148
32ensheathment of neurons (GO:0007272)2.76155148
33peripheral nervous system axon ensheathment (GO:0032292)2.73149309
34myelination in peripheral nervous system (GO:0022011)2.73149309
35cell communication involved in cardiac conduction (GO:0086065)2.72599780
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.72314427
37cardiac muscle hypertrophy (GO:0003300)2.70752122
38embryonic retina morphogenesis in camera-type eye (GO:0060059)2.70481414
39histone H3-K4 methylation (GO:0051568)2.69315662
40hippo signaling (GO:0035329)2.68035049
41negative regulation of Rho protein signal transduction (GO:0035024)2.67858953
42L-amino acid import (GO:0043092)2.66527633
43presynaptic membrane assembly (GO:0097105)2.65529234
44import into cell (GO:0098657)2.65317421
45regulation of somitogenesis (GO:0014807)2.63274988
46striated muscle hypertrophy (GO:0014897)2.63140422
47limb bud formation (GO:0060174)2.62689962
48lung alveolus development (GO:0048286)2.58291629
49negative regulation of hormone metabolic process (GO:0032351)2.58127360
50lateral sprouting from an epithelium (GO:0060601)2.54285569
51nuclear pore organization (GO:0006999)2.53868669
52regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53546710
53positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53546710
54long-chain fatty acid biosynthetic process (GO:0042759)2.52471453
55lymphangiogenesis (GO:0001946)2.52169922
56regulation of actin filament-based movement (GO:1903115)2.50937311
57glomerulus development (GO:0032835)2.50520993
58ventricular cardiac muscle cell action potential (GO:0086005)2.50271601
59cardiac muscle cell development (GO:0055013)2.49526272
60regulation of pigment cell differentiation (GO:0050932)2.49050956
61regulation of phospholipid biosynthetic process (GO:0071071)2.48764398
62regulation of axon extension involved in axon guidance (GO:0048841)2.48672304
63cytoskeletal anchoring at plasma membrane (GO:0007016)2.48326148
64regulation of the force of heart contraction (GO:0002026)2.46757727
65glucocorticoid biosynthetic process (GO:0006704)2.45460349
66cardiac muscle contraction (GO:0060048)2.44707029
67anterior/posterior axis specification, embryo (GO:0008595)2.44657203
68presynaptic membrane organization (GO:0097090)2.43316263
69positive regulation of catenin import into nucleus (GO:0035413)2.42675998
70mitochondrion distribution (GO:0048311)2.42242812
71cell adhesion mediated by integrin (GO:0033627)2.42172251
72negative regulation of potassium ion transmembrane transport (GO:1901380)2.41684110
73fatty acid homeostasis (GO:0055089)2.41087079
74head development (GO:0060322)2.39235609
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39144065
76actomyosin structure organization (GO:0031032)2.38985154
77positive regulation of hormone biosynthetic process (GO:0046886)2.38817612
78smooth muscle tissue development (GO:0048745)2.37904249
79sodium ion export (GO:0071436)2.37278101
80response to redox state (GO:0051775)2.36718466
81relaxation of cardiac muscle (GO:0055119)2.36233820
82regulation of cardiac muscle cell differentiation (GO:2000725)2.35927858
83positive regulation of neurological system process (GO:0031646)2.34164357
84photoreceptor cell differentiation (GO:0046530)2.32661339
85eye photoreceptor cell differentiation (GO:0001754)2.32661339
86cardiac muscle cell action potential (GO:0086001)2.32063553
87regulation of glucocorticoid metabolic process (GO:0031943)2.31282039
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.31241460
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.31184576
90COPII vesicle coating (GO:0048208)2.30846344
91cardiac cell development (GO:0055006)2.29893616
92regulation of cardiac muscle cell contraction (GO:0086004)2.29358745
93regulation of axon guidance (GO:1902667)2.29037894
94cellular response to monoamine stimulus (GO:0071868)2.26948384
95cellular response to catecholamine stimulus (GO:0071870)2.26948384
96gap junction assembly (GO:0016264)2.26478503
97negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.26067917
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.25989703
99regulation of cell communication by electrical coupling (GO:0010649)2.25398462
100glucocorticoid metabolic process (GO:0008211)2.24078141
101response to lipoprotein particle (GO:0055094)2.23689696
102apical protein localization (GO:0045176)2.23416237
103carnitine shuttle (GO:0006853)2.23345332
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23178313
105organ growth (GO:0035265)2.22813070
106response to catecholamine (GO:0071869)2.22697140
107response to monoamine (GO:0071867)2.22697140
108negative regulation of axon extension (GO:0030517)2.22635863
109peptidyl-tyrosine autophosphorylation (GO:0038083)2.22393571
110notochord development (GO:0030903)2.22178586
111negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.21835311
112positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.21793814
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.20119861
114peptidyl-lysine trimethylation (GO:0018023)2.20119291
115cardiac septum development (GO:0003279)2.18708833
116cardiac myofibril assembly (GO:0055003)2.18586974
117neurotransmitter catabolic process (GO:0042135)2.17596837
118protein targeting to Golgi (GO:0000042)2.16557342
119astrocyte development (GO:0014002)2.15974576
120cerebellar Purkinje cell differentiation (GO:0021702)2.15969450
121detection of calcium ion (GO:0005513)2.15702633
122negative regulation of osteoblast proliferation (GO:0033689)2.15701061
123retina layer formation (GO:0010842)2.15229778
124negative regulation of axon extension involved in axon guidance (GO:0048843)2.15119453
125positive regulation of cardiac muscle tissue growth (GO:0055023)2.15002158
126glomerular filtration (GO:0003094)2.14989085
127cardiac muscle adaptation (GO:0014887)2.14909085
128cardiac muscle hypertrophy in response to stress (GO:0014898)2.14909085
129muscle hypertrophy in response to stress (GO:0003299)2.14909085
130coronary vasculature morphogenesis (GO:0060977)2.14630256
131positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.14410450
132cardiac muscle cell action potential involved in contraction (GO:0086002)2.13755275
133myofibril assembly (GO:0030239)2.13554341
134positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.13313386
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.13313386
136NLS-bearing protein import into nucleus (GO:0006607)2.13302938
137negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.13015787
138regulation of keratinocyte proliferation (GO:0010837)2.12687835
139axonal fasciculation (GO:0007413)2.12576457
140positive regulation of hormone metabolic process (GO:0032352)2.12469704
141lung-associated mesenchyme development (GO:0060484)2.12387752
142ventricular cardiac muscle cell development (GO:0055015)2.12172998
143regulation of sarcomere organization (GO:0060297)2.12167088
144positive regulation of cardiac muscle tissue development (GO:0055025)2.11753371
145embryonic heart tube development (GO:0035050)2.10666657
146cellular potassium ion homeostasis (GO:0030007)2.10040732
147adult heart development (GO:0007512)2.09942925
148morphogenesis of an epithelial sheet (GO:0002011)2.08945472
149biotin metabolic process (GO:0006768)2.08859042
150positive regulation of glucose transport (GO:0010828)2.08800835
151negative regulation of neurotransmitter transport (GO:0051589)2.08751603
152righting reflex (GO:0060013)2.08317490
153asymmetric protein localization (GO:0008105)2.08210611
154negative regulation of neurotransmitter secretion (GO:0046929)2.07916449
155fatty acid elongation (GO:0030497)2.06754854
156appendage development (GO:0048736)2.06610784
157limb development (GO:0060173)2.06610784
158regulation of relaxation of muscle (GO:1901077)2.06472865
159actin-myosin filament sliding (GO:0033275)2.06020261
160muscle filament sliding (GO:0030049)2.06020261
161actin-mediated cell contraction (GO:0070252)2.05767272
162dendritic spine morphogenesis (GO:0060997)2.05741950
163positive regulation of muscle hypertrophy (GO:0014742)2.05250618
164positive regulation of cardiac muscle hypertrophy (GO:0010613)2.05250618
165epithelial cell-cell adhesion (GO:0090136)2.05094423
166negative regulation of myoblast differentiation (GO:0045662)2.05082898
167mesenchymal cell differentiation (GO:0048762)2.04938315
168histone H3-K36 demethylation (GO:0070544)2.04791047
169ear development (GO:0043583)2.04750252
170sphingosine metabolic process (GO:0006670)2.04658159
171cardiac muscle tissue morphogenesis (GO:0055008)2.03955032
172muscle hypertrophy (GO:0014896)2.03204230
173branching involved in salivary gland morphogenesis (GO:0060445)2.02564091
174regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.01789790
175artery development (GO:0060840)2.00521161
176regulation of meiosis I (GO:0060631)2.00418213
177myotube differentiation (GO:0014902)2.00162678
178regulation of hormone biosynthetic process (GO:0046885)1.97486302
179positive regulation of male gonad development (GO:2000020)1.96481478
180response to follicle-stimulating hormone (GO:0032354)1.95347563
181atrial septum morphogenesis (GO:0060413)1.94837350
182positive regulation of glucose import (GO:0046326)1.93790360
183protein localization to cell surface (GO:0034394)1.93038364
184androgen biosynthetic process (GO:0006702)1.90847100
185endocardial cushion development (GO:0003197)1.90691820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.12831893
2AR_21909140_ChIP-Seq_LNCAP_Human2.60392033
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50117411
4EZH2_22144423_ChIP-Seq_EOC_Human2.45801458
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45021840
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.40792944
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.37244773
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23060954
9E2F7_22180533_ChIP-Seq_HELA_Human2.18739319
10FUS_26573619_Chip-Seq_HEK293_Human2.10470416
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08926890
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.08542341
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06315640
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06028644
15TAF15_26573619_Chip-Seq_HEK293_Human2.05238309
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05032253
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04527449
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.98976379
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.96560176
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96559636
21TP53_16413492_ChIP-PET_HCT116_Human1.92449186
22AR_21572438_ChIP-Seq_LNCaP_Human1.91009463
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90615521
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90549076
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.87633310
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86301802
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.83713697
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77735198
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.76887491
30SMAD4_21799915_ChIP-Seq_A2780_Human1.72869485
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69832221
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68758537
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68332171
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67707087
35STAT3_23295773_ChIP-Seq_U87_Human1.66295796
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.64722551
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63655036
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63061206
39P300_19829295_ChIP-Seq_ESCs_Human1.62230426
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62117324
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61284475
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61012601
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60677429
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.59005706
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58617171
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58108742
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58085299
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56426711
49CLOCK_20551151_ChIP-Seq_293T_Human1.56188713
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54883661
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54092007
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53792762
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52291398
54ZNF263_19887448_ChIP-Seq_K562_Human1.52271006
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52195901
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52195901
57IGF1R_20145208_ChIP-Seq_DFB_Human1.51589217
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.51126916
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.49804653
60AHR_22903824_ChIP-Seq_MCF-7_Human1.47352302
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.47011448
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46963739
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46653355
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.46017539
65TP53_18474530_ChIP-ChIP_U2OS_Human1.45715337
66TCF4_23295773_ChIP-Seq_U87_Human1.45207978
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.43844913
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43720725
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.43713450
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43525546
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43511979
72DROSHA_22980978_ChIP-Seq_HELA_Human1.41497380
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41121985
74ER_23166858_ChIP-Seq_MCF-7_Human1.39650925
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.39182402
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38540028
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38459130
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37313111
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37206928
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.36944596
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.36023001
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35179883
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.33504500
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33175126
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32669558
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32669558
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32557843
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32456936
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32290709
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31883867
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31883867
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31497324
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31308764
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30411475
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30188281
96BCAT_22108803_ChIP-Seq_LS180_Human1.30141412
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.29022897
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.28233583
99P53_22387025_ChIP-Seq_ESCs_Mouse1.28114393
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.27857017
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26608085
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25484645
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25291498
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24846121
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24548026
106P300_18555785_Chip-Seq_ESCs_Mouse1.24429777
107RUNX2_22187159_ChIP-Seq_PCA_Human1.24308659
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23964890
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23524774
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23153491
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22849383
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22336624
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.21926987
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.21926987
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21764940
116EWS_26573619_Chip-Seq_HEK293_Human1.21404651
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20613823
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.20522239
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.19452532
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19358246
121TBL1_22424771_ChIP-Seq_293T_Human1.18063274
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17335604
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16959550
124OCT4_18555785_Chip-Seq_ESCs_Mouse1.16591091
125LXR_22158963_ChIP-Seq_LIVER_Mouse1.16492281
126SOX9_26525672_Chip-Seq_HEART_Mouse1.15928939
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14587901
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.14256245
129GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13963155
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.13923116
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13282136
132TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13151828
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13015712
134AR_25329375_ChIP-Seq_VCAP_Human1.12962223
135SMAD3_21741376_ChIP-Seq_HESCs_Human1.12330348
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12191144
137RNF2_27304074_Chip-Seq_ESCs_Mouse1.11740126
138BRD4_25478319_ChIP-Seq_HGPS_Human1.10900773
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10061827
140WT1_19549856_ChIP-ChIP_CCG9911_Human1.09747768
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09491237
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09382927
143VDR_22108803_ChIP-Seq_LS180_Human1.08527600
144RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07869333
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06856283
146ESR1_21235772_ChIP-Seq_MCF-7_Human1.06097150
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01704390
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01532061
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01087761
150CJUN_26792858_Chip-Seq_BT549_Human1.00456436
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99252984
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98727000
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96731092
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95208566
155CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94142519
156EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93582129
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92510820
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92000747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation3.44672296
2MP0005409_darkened_coat_color3.34009277
3MP0010368_abnormal_lymphatic_system2.90794030
4MP0004084_abnormal_cardiac_muscle2.73122045
5MP0000569_abnormal_digit_pigmentation2.68713595
6MP0000566_synostosis2.59249119
7MP0003950_abnormal_plasma_membrane2.44234354
8MP0004272_abnormal_basement_membrane2.15955398
9MP0004381_abnormal_hair_follicle2.09266123
10MP0001486_abnormal_startle_reflex2.03903853
11MP0005666_abnormal_adipose_tissue2.03638269
12MP0004185_abnormal_adipocyte_glucose2.03333826
13MP0003136_yellow_coat_color1.96286392
14MP0001661_extended_life_span1.92820583
15MP0005670_abnormal_white_adipose1.87361516
16MP0000383_abnormal_hair_follicle1.85651880
17MP0002837_dystrophic_cardiac_calcinosis1.81368754
18MP0010234_abnormal_vibrissa_follicle1.76818765
19MP0000462_abnormal_digestive_system1.76592190
20MP0002009_preneoplasia1.75515958
21MP0010352_gastrointestinal_tract_polyps1.72014647
22MP0004215_abnormal_myocardial_fiber1.69801997
23MP0001188_hyperpigmentation1.69034431
24MP0008775_abnormal_heart_ventricle1.68423833
25MP0003787_abnormal_imprinting1.67585465
26MP0003045_fibrosis1.63491143
27MP0003137_abnormal_impulse_conducting1.61142907
28MP0004270_analgesia1.56337434
29MP0010678_abnormal_skin_adnexa1.52812181
30MP0000920_abnormal_myelination1.49881824
31MP0003566_abnormal_cell_adhesion1.49869028
32MP0005375_adipose_tissue_phenotype1.46854073
33MP0003937_abnormal_limbs/digits/tail_de1.45602811
34MP0003880_abnormal_central_pattern1.44417438
35MP0008438_abnormal_cutaneous_collagen1.43974596
36MP0002877_abnormal_melanocyte_morpholog1.43113949
37MP0004742_abnormal_vestibular_system1.41884525
38MP0000372_irregular_coat_pigmentation1.41158678
39MP0002108_abnormal_muscle_morphology1.40004756
40MP0005623_abnormal_meninges_morphology1.39466446
41MP0000537_abnormal_urethra_morphology1.39403796
42MP0004484_altered_response_of1.39253013
43MP0010030_abnormal_orbit_morphology1.38880730
44MP0001177_atelectasis1.35350273
45MP0008057_abnormal_DNA_replication1.35002671
46MP0005408_hypopigmentation1.34386882
47MP0009780_abnormal_chondrocyte_physiolo1.33530987
48MP0000778_abnormal_nervous_system1.33082485
49MP0004233_abnormal_muscle_weight1.31412962
50MP0002168_other_aberrant_phenotype1.31369187
51MP0005423_abnormal_somatic_nervous1.31274465
52MP0002269_muscular_atrophy1.29275475
53MP0005330_cardiomyopathy1.29072511
54MP0000003_abnormal_adipose_tissue1.28294728
55MP0000013_abnormal_adipose_tissue1.27944006
56MP0003567_abnormal_fetal_cardiomyocyte1.26182186
57MP0005620_abnormal_muscle_contractility1.24505392
58MP0005551_abnormal_eye_electrophysiolog1.22765013
59MP0002972_abnormal_cardiac_muscle1.21710993
60MP0003690_abnormal_glial_cell1.19662087
61MP0001958_emphysema1.17669363
62MP0000751_myopathy1.17613241
63MP0003123_paternal_imprinting1.16045499
64MP0003828_pulmonary_edema1.16042916
65MP0000534_abnormal_ureter_morphology1.14734137
66MP0000579_abnormal_nail_morphology1.13109619
67MP0004130_abnormal_muscle_cell1.12784379
68MP0004145_abnormal_muscle_electrophysio1.12471444
69MP0009046_muscle_twitch1.11887188
70MP0003283_abnormal_digestive_organ1.09035737
71MP0003632_abnormal_nervous_system1.08565429
72MP0001299_abnormal_eye_distance/1.08328000
73MP0010630_abnormal_cardiac_muscle1.07452762
74MP0005275_abnormal_skin_tensile1.07082773
75MP0002697_abnormal_eye_size1.04644189
76MP0002084_abnormal_developmental_patter1.04563123
77MP0004147_increased_porphyrin_level1.03921616
78MP0004885_abnormal_endolymph1.01928917
79MP0005646_abnormal_pituitary_gland1.01740875
80MP0006138_congestive_heart_failure1.00788542
81MP0009384_cardiac_valve_regurgitation0.97803441
82MP0002909_abnormal_adrenal_gland0.96002015
83MP0005257_abnormal_intraocular_pressure0.95407150
84MP0001544_abnormal_cardiovascular_syste0.95397356
85MP0005385_cardiovascular_system_phenoty0.95397356
86MP0003705_abnormal_hypodermis_morpholog0.94694481
87MP0004085_abnormal_heartbeat0.94642110
88MP0009697_abnormal_copulation0.94416147
89MP0000427_abnormal_hair_cycle0.94124214
90MP0003890_abnormal_embryonic-extraembry0.93842059
91MP0003942_abnormal_urinary_system0.93541693
92MP0003935_abnormal_craniofacial_develop0.93174752
93MP0000747_muscle_weakness0.92670148
94MP0000015_abnormal_ear_pigmentation0.92482163
95MP0002272_abnormal_nervous_system0.92203974
96MP0005451_abnormal_body_composition0.92187200
97MP0002088_abnormal_embryonic_growth/wei0.92151158
98MP0003984_embryonic_growth_retardation0.92099468
99MP0001730_embryonic_growth_arrest0.91543758
100MP0005388_respiratory_system_phenotype0.90927293
101MP0002133_abnormal_respiratory_system0.90927293
102MP0003385_abnormal_body_wall0.90359308
103MP0001440_abnormal_grooming_behavior0.90264778
104MP0005503_abnormal_tendon_morphology0.90264087
105MP0003941_abnormal_skin_development0.90171376
106MP0000432_abnormal_head_morphology0.89906248
107MP0002295_abnormal_pulmonary_circulatio0.89572672
108MP0002106_abnormal_muscle_physiology0.89506677
109MP0009703_decreased_birth_body0.88757352
110MP0005369_muscle_phenotype0.88018171
111MP0009672_abnormal_birth_weight0.87338634
112MP0003122_maternal_imprinting0.87215278
113MP0001697_abnormal_embryo_size0.86962267
114MP0005380_embryogenesis_phenotype0.86626754
115MP0001672_abnormal_embryogenesis/_devel0.86626754
116MP0000428_abnormal_craniofacial_morphol0.86625569
117MP0000266_abnormal_heart_morphology0.86387757
118MP0004087_abnormal_muscle_fiber0.85829437
119MP0009745_abnormal_behavioral_response0.85809098
120MP0000639_abnormal_adrenal_gland0.85260392
121MP0001879_abnormal_lymphatic_vessel0.83927281
122MP0002734_abnormal_mechanical_nocicepti0.83765364
123MP0005645_abnormal_hypothalamus_physiol0.83672735
124MP0002086_abnormal_extraembryonic_tissu0.83354240
125MP0004036_abnormal_muscle_relaxation0.82619782
126MP0002971_abnormal_brown_adipose0.82600635
127MP0000749_muscle_degeneration0.82584887
128MP0000733_abnormal_muscle_development0.81739813
129MP0003868_abnormal_feces_composition0.81098152
130MP0001346_abnormal_lacrimal_gland0.80813940
131MP0005076_abnormal_cell_differentiation0.80784010
132MP0001963_abnormal_hearing_physiology0.79806547
133MP0000647_abnormal_sebaceous_gland0.79792537
134MP0001485_abnormal_pinna_reflex0.79695342
135MP0002067_abnormal_sensory_capabilities0.79688661
136MP0003938_abnormal_ear_development0.79099339
137MP0002896_abnormal_bone_mineralization0.78372731
138MP0004197_abnormal_fetal_growth/weight/0.78316995
139MP0002064_seizures0.76943176
140MP0000762_abnormal_tongue_morphology0.76837890
141MP0002233_abnormal_nose_morphology0.76152492
142MP0001984_abnormal_olfaction0.75942880
143MP0001986_abnormal_taste_sensitivity0.75076350
144MP0004142_abnormal_muscle_tone0.74970001
145MP0004264_abnormal_extraembryonic_tissu0.74946272
146MP0002876_abnormal_thyroid_physiology0.74812899
147MP0008004_abnormal_stomach_pH0.74674768
148MP0008877_abnormal_DNA_methylation0.74169032
149MP0002085_abnormal_embryonic_tissue0.71799226
150MP0003119_abnormal_digestive_system0.71596619
151MP0001915_intracranial_hemorrhage0.69962505
152MP0002127_abnormal_cardiovascular_syste0.69456910
153MP0002128_abnormal_blood_circulation0.69073172

Predicted human phenotypes

RankGene SetZ-score
1Bundle branch block (HP:0011710)3.66676630
2Tubulointerstitial nephritis (HP:0001970)2.96654864
3Aplasia cutis congenita (HP:0001057)2.90409524
4Abnormality of the nasal septum (HP:0000419)2.89380147
5Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89361511
6Sensory axonal neuropathy (HP:0003390)2.84459053
7Chromsome breakage (HP:0040012)2.83410463
8Abnormality of incisor morphology (HP:0011063)2.71545899
9Ulnar claw (HP:0001178)2.61758272
10Ventricular tachycardia (HP:0004756)2.58903320
11Degeneration of the lateral corticospinal tracts (HP:0002314)2.49633509
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49633509
13Prostate neoplasm (HP:0100787)2.46033597
14Sudden death (HP:0001699)2.43868235
15Duplicated collecting system (HP:0000081)2.41277811
16Prolonged QT interval (HP:0001657)2.37450764
17Hypoplasia of the iris (HP:0007676)2.35811848
18Osteomalacia (HP:0002749)2.33853801
19Midline defect of the nose (HP:0004122)2.32529849
20Muscle hypertrophy of the lower extremities (HP:0008968)2.32402742
21Chronic hepatic failure (HP:0100626)2.31029218
22Hyporeflexia of lower limbs (HP:0002600)2.29771341
23Calf muscle hypertrophy (HP:0008981)2.29605091
24Hypoplastic ischia (HP:0003175)2.29405417
25Arterial tortuosity (HP:0005116)2.25938191
26Febrile seizures (HP:0002373)2.25677170
27Stomach cancer (HP:0012126)2.24844366
28Vascular tortuosity (HP:0004948)2.23893315
29Onion bulb formation (HP:0003383)2.23705172
30Hypoglycemic seizures (HP:0002173)2.22322838
31Abnormality of the renal collecting system (HP:0004742)2.19850496
32Steppage gait (HP:0003376)2.19238515
33Abnormality of the left ventricular outflow tract (HP:0011103)2.18633192
34Hyperkalemia (HP:0002153)2.16511780
35Drooling (HP:0002307)2.16291950
36Excessive salivation (HP:0003781)2.16291950
37Abnormality of the right ventricle (HP:0001707)2.14251758
38Absent speech (HP:0001344)2.13727655
39Hyperinsulinemic hypoglycemia (HP:0000825)2.12866016
40Syncope (HP:0001279)2.11832006
41Hyperglycemia (HP:0003074)2.11176165
42Abnormality of the parietal bone (HP:0002696)2.09337557
43Cupped ear (HP:0000378)2.09266197
44Vascular calcification (HP:0004934)2.07679922
45Abnormal hair whorl (HP:0010721)2.07654657
46Cardiovascular calcification (HP:0011915)2.07208586
47Limited hip movement (HP:0008800)2.07166823
48Aqueductal stenosis (HP:0002410)2.04767334
49Broad-based gait (HP:0002136)2.04750653
50Atrial fibrillation (HP:0005110)2.04423210
51Ectopic kidney (HP:0000086)2.03506099
52Anal stenosis (HP:0002025)2.03064278
53Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.02444074
54Blue irides (HP:0000635)2.02050746
55Abnormality of the fingertips (HP:0001211)2.02010017
56Hypoalphalipoproteinemia (HP:0003233)1.99758002
57Increased circulating renin level (HP:0000848)1.99456568
58Termporal pattern (HP:0011008)1.98852407
59Insidious onset (HP:0003587)1.98852407
60Lip pit (HP:0100267)1.98260985
61Widely spaced teeth (HP:0000687)1.98169323
62Alacrima (HP:0000522)1.97551097
63Abnormality of the ischium (HP:0003174)1.97473436
64Lipoatrophy (HP:0100578)1.96469963
65Enlarged penis (HP:0000040)1.95965850
66Supernumerary ribs (HP:0005815)1.95529311
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94911242
68Supraventricular tachycardia (HP:0004755)1.94558954
69Focal motor seizures (HP:0011153)1.93064440
70Supraventricular arrhythmia (HP:0005115)1.92911144
71Decreased lacrimation (HP:0000633)1.92903533
72Papillary thyroid carcinoma (HP:0002895)1.92503537
73Hypoplastic nipples (HP:0002557)1.90219484
74Oligodactyly (hands) (HP:0001180)1.89857189
75Volvulus (HP:0002580)1.89270741
76Hypolipoproteinemia (HP:0010981)1.89114125
77Heart block (HP:0012722)1.87681356
78Peripheral hypomyelination (HP:0007182)1.86195735
79Abnormal atrioventricular conduction (HP:0005150)1.85907783
80Action tremor (HP:0002345)1.85883503
81Aortic aneurysm (HP:0004942)1.85280072
82Abnormality of salivation (HP:0100755)1.85199127
83Hypoglycemic coma (HP:0001325)1.84858548
84Supernumerary bones of the axial skeleton (HP:0009144)1.83789340
85Nasolacrimal duct obstruction (HP:0000579)1.83780039
86Upper limb muscle weakness (HP:0003484)1.83571088
87Long eyelashes (HP:0000527)1.82470585
88Insulin-resistant diabetes mellitus (HP:0000831)1.82315265
89Abnormality of the nasolacrimal system (HP:0000614)1.81938463
90Decreased motor nerve conduction velocity (HP:0003431)1.81777642
91Abnormality of the calf musculature (HP:0001430)1.80194744
92Congenital sensorineural hearing impairment (HP:0008527)1.80024439
93Pulmonary artery stenosis (HP:0004415)1.79990896
94Coronal craniosynostosis (HP:0004440)1.78627953
95Dilated cardiomyopathy (HP:0001644)1.78082533
96Adrenal hypoplasia (HP:0000835)1.77982685
97Macroorchidism (HP:0000053)1.77266725
98Fair hair (HP:0002286)1.75943810
99Aplasia involving bones of the upper limbs (HP:0009823)1.75170628
100Aplasia of the phalanges of the hand (HP:0009802)1.75170628
101Aplasia involving bones of the extremities (HP:0009825)1.75170628
102Protrusio acetabuli (HP:0003179)1.74352603
103Narrow palate (HP:0000189)1.74044349
104Bell-shaped thorax (HP:0001591)1.73291349
105Heterotopia (HP:0002282)1.72578254
106Primary atrial arrhythmia (HP:0001692)1.72218426
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72014571
108Acanthocytosis (HP:0001927)1.70238097
109Depressed nasal tip (HP:0000437)1.69794706
110Ventricular arrhythmia (HP:0004308)1.68532162
111Dysmetric saccades (HP:0000641)1.68374927
112Abnormality of the lacrimal duct (HP:0011481)1.68339358
113Abnormality of the incisor (HP:0000676)1.68207641
114Nemaline bodies (HP:0003798)1.67468104
115Gaze-evoked nystagmus (HP:0000640)1.67064058
116Ankyloglossia (HP:0010296)1.66751492
117Exercise-induced myalgia (HP:0003738)1.66159976
118Relative macrocephaly (HP:0004482)1.66140599
119Urethral obstruction (HP:0000796)1.65991773
120Long nose (HP:0003189)1.65915087
121Muscle fiber inclusion bodies (HP:0100299)1.65802117
122Renal cortical cysts (HP:0000803)1.65518145
123Abnormality of the corticospinal tract (HP:0002492)1.64362920
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62814435
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.62560540
126Osteolytic defects of the hand bones (HP:0009699)1.62560540
127Partial agenesis of the corpus callosum (HP:0001338)1.62433276
128Cutaneous finger syndactyly (HP:0010554)1.61674056
129Progressive external ophthalmoplegia (HP:0000590)1.60886276
130Parakeratosis (HP:0001036)1.60802363
131Abnormality of molar morphology (HP:0011070)1.60782774
132Abnormality of molar (HP:0011077)1.60782774
133Vertebral arch anomaly (HP:0008438)1.60359021
134Astrocytoma (HP:0009592)1.60289766
135Abnormality of the astrocytes (HP:0100707)1.60289766
136Right ventricular cardiomyopathy (HP:0011663)1.60246119
137Proximal tubulopathy (HP:0000114)1.59763608
138Impaired pain sensation (HP:0007328)1.59430061
139Abnormality of pain sensation (HP:0010832)1.59430061
140Difficulty running (HP:0009046)1.59190378
141Generalized hypopigmentation of hair (HP:0011358)1.58404919
142Hip contracture (HP:0003273)1.57625660
143Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.57443760
144Abnormality of the renal cortex (HP:0011035)1.57223531
145Anteriorly placed anus (HP:0001545)1.56962911
146Hypobetalipoproteinemia (HP:0003563)1.55651376
147Focal seizures (HP:0007359)1.55186076
148Subaortic stenosis (HP:0001682)1.54854937
149Short humerus (HP:0005792)1.54238191
150Hyperaldosteronism (HP:0000859)1.53224267
151Shallow orbits (HP:0000586)1.51481174
152Choanal stenosis (HP:0000452)1.49107842
153Asymmetry of the thorax (HP:0001555)1.48994113
154Mitral stenosis (HP:0001718)1.48719932
155Hyperphosphatemia (HP:0002905)1.48200842
156Asymmetric septal hypertrophy (HP:0001670)1.47113916
157Knee flexion contracture (HP:0006380)1.46989142
158Pancreatic islet-cell hyperplasia (HP:0004510)1.46883229
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.46769052
160Cubitus valgus (HP:0002967)1.46759787
161Advanced eruption of teeth (HP:0006288)1.46479021
162Premature rupture of membranes (HP:0001788)1.46014430
163Late onset (HP:0003584)1.45418683
164Increased nuchal translucency (HP:0010880)1.44784829
165Myoglobinuria (HP:0002913)1.44652704
166Absent eyebrow (HP:0002223)1.44232388
167Ependymoma (HP:0002888)1.43497145
168Hypokalemic alkalosis (HP:0001949)1.43361782
169Atrioventricular block (HP:0001678)1.42386419
170Abnormality of oral frenula (HP:0000190)1.40905555
171Exercise-induced muscle cramps (HP:0003710)1.39506615
172Bronchomalacia (HP:0002780)1.39421165
173Biliary tract neoplasm (HP:0100574)1.39315961
174Vertebral clefting (HP:0008428)1.38472907
175Aortic dissection (HP:0002647)1.38166308
176Skin nodule (HP:0200036)1.37758244
177Flat acetabular roof (HP:0003180)1.36147198
178Hypercalciuria (HP:0002150)1.35522344
179Cutaneous syndactyly (HP:0012725)1.35301116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.37467736
2CAMK1D2.82014305
3CAMK1G2.78999737
4STK392.78236095
5ZAK2.41636199
6STK38L2.38250577
7MST1R2.15230636
8INSRR2.14633435
9WNK12.07549780
10CDK122.00024290
11BRD41.94223154
12IRAK31.92226032
13NUAK11.82985210
14LATS21.81611682
15PDGFRA1.81531362
16FGFR21.67334538
17CASK1.67220222
18STK31.60102797
19PNCK1.55612607
20OXSR11.44731225
21TNIK1.44464784
22IRAK21.44332941
23PKN11.41254141
24DMPK1.41153943
25MYLK1.40609579
26FRK1.39723864
27LMTK21.38381785
28NTRK31.37390621
29SCYL21.37343494
30NTRK11.37000903
31NEK91.32651502
32ICK1.30520465
33MELK1.29535280
34TTK1.27787499
35BRSK21.26873804
36MAP3K21.24654936
37OBSCN1.23472063
38WNK41.22455726
39RIPK11.22340752
40PTK21.20934458
41ACVR1B1.18784222
42MAP3K91.17430162
43PKN21.17386582
44CDC42BPA1.16947383
45STK381.16825701
46PIK3CA1.16473499
47PDGFRB1.13952537
48NEK61.10180400
49PRKAA21.02406788
50EIF2AK11.01495804
51PRKD21.01245546
52MAPK130.98781929
53AKT30.95778036
54WNK30.95580900
55GRK70.95132805
56ERBB40.93872898
57FGFR30.92466072
58IRAK10.91458701
59PRKCE0.90897625
60PLK20.89115132
61CDK30.87795353
62MAP3K120.87545676
63BMPR1B0.87503529
64MUSK0.87267133
65KSR10.87132682
66BRSK10.84552988
67EPHA40.83542102
68CLK10.83535962
69MARK20.83374595
70SGK4940.82112841
71SGK2230.82112841
72KSR20.80764143
73FGFR10.80574658
74MAP3K40.80525318
75SGK20.78868871
76WEE10.78025325
77MET0.76813739
78EPHB10.76093216
79PRKAA10.76035498
80MAP3K60.75540761
81CAMK2D0.75325652
82NEK10.75076218
83BRAF0.74858075
84PRKCQ0.74827805
85FER0.74780606
86PLK30.74238937
87STK240.74074855
88GRK10.73645515
89MARK10.73244913
90SGK10.72762949
91CDK90.72740152
92MAP3K70.72638967
93RET0.72405535
94TRPM70.71735988
95MTOR0.71282667
96MST40.71049307
97CSNK1A1L0.68460977
98MAP2K10.67831412
99BCR0.67546947
100PAK20.67377566
101EEF2K0.67225543
102PAK60.66605834
103MAP3K100.66360420
104FGR0.64043998
105EPHA20.63074095
106EIF2AK20.61903680
107PHKG10.60490916
108PHKG20.60490916
109CAMK2A0.60351344
110STK110.60113850
111TAF10.59361394
112YES10.58450627
113PLK10.58423282
114PRKD10.57444292
115TTN0.56843316
116SGK30.56788132
117MAPK70.56136689
118ROCK10.55949595
119NEK20.55890196
120PDK20.55539528
121PBK0.54544789
122FLT30.53500190
123PRKCH0.52421286
124MKNK20.52337999
125PAK30.52208088
126MAPK100.51844697
127FGFR40.51736977
128NLK0.51733050
129PRKG10.51666520
130TIE10.51091034
131MAP2K70.50854911
132CSNK1G10.50537430
133ATM0.50000991
134IRAK40.47774455
135AKT20.47145665
136CSNK1D0.46879011
137MAPKAPK50.46806933
138CAMK10.46538657
139PLK40.46450375
140MAP3K130.46249649
141ABL10.46111217
142ROCK20.45844532
143CHEK20.45609972
144CAMK2B0.45061226
145SIK10.44726027
146INSR0.44346534
147RPS6KB10.42325879
148RAF10.41244897
149PRKD30.40720971

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.11578847
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92770817
3Fatty acid biosynthesis_Homo sapiens_hsa000611.80069502
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.79339125
5ECM-receptor interaction_Homo sapiens_hsa045121.76536566
6Dilated cardiomyopathy_Homo sapiens_hsa054141.76351623
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75921873
8Dorso-ventral axis formation_Homo sapiens_hsa043201.72859238
9Lysine degradation_Homo sapiens_hsa003101.72522257
10Fatty acid elongation_Homo sapiens_hsa000621.70349086
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69157168
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65591423
13Taste transduction_Homo sapiens_hsa047421.63981606
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63750796
15Axon guidance_Homo sapiens_hsa043601.60879282
16Nicotine addiction_Homo sapiens_hsa050331.60843048
17Sphingolipid metabolism_Homo sapiens_hsa006001.50103530
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49434593
19Glutamatergic synapse_Homo sapiens_hsa047241.47329573
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44551185
21Serotonergic synapse_Homo sapiens_hsa047261.44505944
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44076243
23Ether lipid metabolism_Homo sapiens_hsa005651.42714724
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39042413
25Renin secretion_Homo sapiens_hsa049241.36424050
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33917212
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33318239
28Salivary secretion_Homo sapiens_hsa049701.31540354
29Phototransduction_Homo sapiens_hsa047441.31333327
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30673251
31Ovarian steroidogenesis_Homo sapiens_hsa049131.30328798
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28689679
33Cardiac muscle contraction_Homo sapiens_hsa042601.27221211
34Morphine addiction_Homo sapiens_hsa050321.22509554
35Adherens junction_Homo sapiens_hsa045201.21072452
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20805013
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19503684
38Arginine biosynthesis_Homo sapiens_hsa002201.19259076
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17476696
40Cholinergic synapse_Homo sapiens_hsa047251.16703164
41Thyroid hormone synthesis_Homo sapiens_hsa049181.16553928
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16076831
43Gastric acid secretion_Homo sapiens_hsa049711.16051295
44Fatty acid degradation_Homo sapiens_hsa000711.15496057
45Pyruvate metabolism_Homo sapiens_hsa006201.15003149
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14955639
47Basal cell carcinoma_Homo sapiens_hsa052171.14825282
48Calcium signaling pathway_Homo sapiens_hsa040201.14570658
49Circadian entrainment_Homo sapiens_hsa047131.13338367
50Bile secretion_Homo sapiens_hsa049761.12696785
51Steroid biosynthesis_Homo sapiens_hsa001001.10446751
52Type II diabetes mellitus_Homo sapiens_hsa049301.08778640
53Choline metabolism in cancer_Homo sapiens_hsa052311.08087097
54cAMP signaling pathway_Homo sapiens_hsa040241.07597128
55Thyroid cancer_Homo sapiens_hsa052161.05588569
56Prostate cancer_Homo sapiens_hsa052151.05072564
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04210885
58Fanconi anemia pathway_Homo sapiens_hsa034601.03184876
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.03082423
60Focal adhesion_Homo sapiens_hsa045101.03065107
61Fatty acid metabolism_Homo sapiens_hsa012121.01953652
62ErbB signaling pathway_Homo sapiens_hsa040121.01255355
63GnRH signaling pathway_Homo sapiens_hsa049121.00721241
64Amphetamine addiction_Homo sapiens_hsa050311.00587453
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00496104
66Melanogenesis_Homo sapiens_hsa049160.98895743
67Long-term depression_Homo sapiens_hsa047300.98833645
68Insulin secretion_Homo sapiens_hsa049110.98509788
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96083946
70Hedgehog signaling pathway_Homo sapiens_hsa043400.95866653
71Propanoate metabolism_Homo sapiens_hsa006400.94882828
72Tight junction_Homo sapiens_hsa045300.94357509
73Oxytocin signaling pathway_Homo sapiens_hsa049210.94249512
74Inositol phosphate metabolism_Homo sapiens_hsa005620.92976436
75Ras signaling pathway_Homo sapiens_hsa040140.91547504
76Oocyte meiosis_Homo sapiens_hsa041140.91173559
77Wnt signaling pathway_Homo sapiens_hsa043100.90631809
78Oxidative phosphorylation_Homo sapiens_hsa001900.88733131
79GABAergic synapse_Homo sapiens_hsa047270.87936252
80Long-term potentiation_Homo sapiens_hsa047200.87117251
81Alzheimers disease_Homo sapiens_hsa050100.86944422
82MicroRNAs in cancer_Homo sapiens_hsa052060.86692405
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86492153
84Insulin signaling pathway_Homo sapiens_hsa049100.85941189
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.85764653
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82974567
87Renal cell carcinoma_Homo sapiens_hsa052110.82520174
88Endometrial cancer_Homo sapiens_hsa052130.82154809
89mTOR signaling pathway_Homo sapiens_hsa041500.81490079
90Carbon metabolism_Homo sapiens_hsa012000.80155992
91Melanoma_Homo sapiens_hsa052180.79468957
92Cell cycle_Homo sapiens_hsa041100.75641466
93Glioma_Homo sapiens_hsa052140.75577391
94Dopaminergic synapse_Homo sapiens_hsa047280.75090704
95Non-homologous end-joining_Homo sapiens_hsa034500.74382598
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74122636
97Mineral absorption_Homo sapiens_hsa049780.73124070
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.73057532
99Small cell lung cancer_Homo sapiens_hsa052220.72938318
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.72930827
101Phenylalanine metabolism_Homo sapiens_hsa003600.72590616
102Cocaine addiction_Homo sapiens_hsa050300.71752929
103Hippo signaling pathway_Homo sapiens_hsa043900.71720395
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71056443
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70566523
106Selenocompound metabolism_Homo sapiens_hsa004500.68715746
107Glycerolipid metabolism_Homo sapiens_hsa005610.68555688
108Protein digestion and absorption_Homo sapiens_hsa049740.67199291
109Gap junction_Homo sapiens_hsa045400.66832642
110Rap1 signaling pathway_Homo sapiens_hsa040150.64983053
111Complement and coagulation cascades_Homo sapiens_hsa046100.64874395
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64112146
113beta-Alanine metabolism_Homo sapiens_hsa004100.63983838
114Pancreatic secretion_Homo sapiens_hsa049720.63851830
115ABC transporters_Homo sapiens_hsa020100.63784614
116TGF-beta signaling pathway_Homo sapiens_hsa043500.63658833
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62777579
118Pathways in cancer_Homo sapiens_hsa052000.62663099
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62246675
120AMPK signaling pathway_Homo sapiens_hsa041520.61951629
121FoxO signaling pathway_Homo sapiens_hsa040680.61874252
122PPAR signaling pathway_Homo sapiens_hsa033200.61839959
123Tyrosine metabolism_Homo sapiens_hsa003500.61381981
124Circadian rhythm_Homo sapiens_hsa047100.61177860
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60832840
126Glucagon signaling pathway_Homo sapiens_hsa049220.60813245
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59902609
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.59426600
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59329524
130Arginine and proline metabolism_Homo sapiens_hsa003300.58658381
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58613779
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.57787597
133MAPK signaling pathway_Homo sapiens_hsa040100.57595729
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.57029248
135Histidine metabolism_Homo sapiens_hsa003400.56873756
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56869485
137Insulin resistance_Homo sapiens_hsa049310.56816816
138Starch and sucrose metabolism_Homo sapiens_hsa005000.56398499
139N-Glycan biosynthesis_Homo sapiens_hsa005100.55420996
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55363624
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52510442
142Butanoate metabolism_Homo sapiens_hsa006500.52126937
143Proteoglycans in cancer_Homo sapiens_hsa052050.51818123
144Estrogen signaling pathway_Homo sapiens_hsa049150.49949429

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