TMEM247

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.89810518
2plasma membrane fusion (GO:0045026)9.87180793
3epithelial cilium movement (GO:0003351)9.52238223
4reproduction (GO:0000003)9.47167756
5axonemal dynein complex assembly (GO:0070286)9.33474331
6motile cilium assembly (GO:0044458)9.21697884
7regulation of cilium movement (GO:0003352)8.40167660
8cilium or flagellum-dependent cell motility (GO:0001539)7.84885099
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.69770462
10cilium movement (GO:0003341)7.68996500
11positive regulation of catecholamine secretion (GO:0033605)7.65348422
12regulation of phosphoprotein phosphatase activity (GO:0043666)7.57626141
13negative regulation of inclusion body assembly (GO:0090084)7.48233714
14sperm capacitation (GO:0048240)7.40029505
15single fertilization (GO:0007338)7.24506572
16synaptonemal complex organization (GO:0070193)7.10295552
17synaptonemal complex assembly (GO:0007130)7.08646958
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.01396418
19spermatogenesis (GO:0007283)6.89326887
20organic cation transport (GO:0015695)6.86960935
21male gamete generation (GO:0048232)6.86791246
22male meiosis (GO:0007140)6.85871038
23microtubule depolymerization (GO:0007019)6.52504651
24regulation of oxidative phosphorylation (GO:0002082)6.39793017
25regulation of oxidative stress-induced neuron death (GO:1903203)6.33106858
26gamete generation (GO:0007276)6.31021386
27piRNA metabolic process (GO:0034587)6.30540829
28regulation of inclusion body assembly (GO:0090083)6.24082403
29fertilization (GO:0009566)6.14941848
30spermatid nucleus differentiation (GO:0007289)5.94399473
31chromosome condensation (GO:0030261)5.86878185
32calcium ion-dependent exocytosis (GO:0017156)5.79015225
33DNA packaging (GO:0006323)5.52840429
34germ cell development (GO:0007281)5.44494464
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.41213462
36potassium ion export (GO:0071435)5.34538485
37TOR signaling (GO:0031929)5.21493654
38cell recognition (GO:0008037)5.18676927
39glycerol ether metabolic process (GO:0006662)5.17839983
40microtubule severing (GO:0051013)5.01991149
41multicellular organismal reproductive process (GO:0048609)4.95337052
42ventricular system development (GO:0021591)4.94896290
43regulation of microtubule-based movement (GO:0060632)4.94256543
44sexual reproduction (GO:0019953)4.92488729
45ether metabolic process (GO:0018904)4.78693687
46chromosome organization involved in meiosis (GO:0070192)4.76620917
47histone exchange (GO:0043486)4.65997266
48activation of protein kinase B activity (GO:0032148)4.61297938
49single strand break repair (GO:0000012)4.59180650
50negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.55408374
51seminiferous tubule development (GO:0072520)4.54573887
52histone H3-K9 demethylation (GO:0033169)4.52092954
53male meiosis I (GO:0007141)4.44211285
54regulation of hydrogen peroxide-induced cell death (GO:1903205)4.43059755
55diterpenoid biosynthetic process (GO:0016102)4.40940616
56relaxation of smooth muscle (GO:0044557)4.30472620
57coenzyme catabolic process (GO:0009109)4.28589907
58androgen biosynthetic process (GO:0006702)4.27483644
59chaperone-mediated protein complex assembly (GO:0051131)4.24105329
60male sex determination (GO:0030238)4.15163555
61DNA methylation involved in gamete generation (GO:0043046)4.12098211
62negative regulation of response to reactive oxygen species (GO:1901032)4.11616991
63DNA double-strand break processing (GO:0000729)4.07920680
64meiotic nuclear division (GO:0007126)4.05641705
65left/right pattern formation (GO:0060972)4.04003512
66sequestering of actin monomers (GO:0042989)4.00467299
67terpenoid biosynthetic process (GO:0016114)4.00320093
68multicellular organismal development (GO:0007275)4.00051582
69centriole assembly (GO:0098534)3.90783221
70detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.87690397
71regulation of cellular respiration (GO:0043457)3.73222118
72regulation of dopamine secretion (GO:0014059)3.67690040
73protein polyglutamylation (GO:0018095)3.66044262
74protein K11-linked deubiquitination (GO:0035871)3.65088461
75regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.57333999
76negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.53530689
77meiosis I (GO:0007127)3.52555394
78N-terminal protein amino acid acetylation (GO:0006474)3.46435567
79glutamine family amino acid catabolic process (GO:0009065)3.43196932
80positive regulation of glycolytic process (GO:0045821)3.42163886
81genitalia morphogenesis (GO:0035112)3.41203972
82positive regulation of macrophage activation (GO:0043032)3.40396847
83regulation of spindle checkpoint (GO:0090231)3.38528540
84membrane repolarization during action potential (GO:0086011)3.36704313
85microtubule polymerization or depolymerization (GO:0031109)3.34818456
86ADP metabolic process (GO:0046031)3.26807281
87protein refolding (GO:0042026)3.24272495
88regulation of acyl-CoA biosynthetic process (GO:0050812)3.22892078
89Leydig cell differentiation (GO:0033327)3.22630017
90granulocyte differentiation (GO:0030851)3.21330451
91regulation of autophagic vacuole assembly (GO:2000785)3.18309558
92protein polymerization (GO:0051258)3.16657120
93positive regulation of amine transport (GO:0051954)3.16197037
94aspartate family amino acid catabolic process (GO:0009068)3.15571874
95nucleus organization (GO:0006997)3.14768586
96interferon-gamma secretion (GO:0072643)3.14254249
97glycolytic process (GO:0006096)3.13676913
98monoubiquitinated protein deubiquitination (GO:0035520)3.12706573
99mRNA cleavage (GO:0006379)3.12422479
100cGMP-mediated signaling (GO:0019934)3.12191331
101carnitine transport (GO:0015879)3.12114587
102amino-acid betaine transport (GO:0015838)3.12114587
103centriole replication (GO:0007099)3.08346969
104resolution of meiotic recombination intermediates (GO:0000712)3.06334381
105regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05961728
106meiotic cell cycle (GO:0051321)3.03518118
107DNA replication initiation (GO:0006270)3.03169786
108glycogen metabolic process (GO:0005977)3.02861551
109rRNA modification (GO:0000154)3.01627411
110cellular response to toxic substance (GO:0097237)3.01408144
111oogenesis (GO:0048477)3.01074740
112DNA synthesis involved in DNA repair (GO:0000731)3.00730328
113amine biosynthetic process (GO:0009309)2.99824830
114glucan metabolic process (GO:0044042)2.99337004
115cellular glucan metabolic process (GO:0006073)2.99337004
116regulation of synaptic transmission, dopaminergic (GO:0032225)2.97979643
117polyamine biosynthetic process (GO:0006596)2.96093694
118mitotic sister chromatid cohesion (GO:0007064)2.96088666
119chromatin silencing (GO:0006342)2.95940468
120nucleoside diphosphate phosphorylation (GO:0006165)2.94246272
121carnitine transmembrane transport (GO:1902603)2.94121733
122AMP metabolic process (GO:0046033)2.93703025
123protein localization to cilium (GO:0061512)2.91110946
124negative regulation of translational initiation (GO:0045947)2.90152596
125cellular biogenic amine biosynthetic process (GO:0042401)2.90030914
126rRNA methylation (GO:0031167)2.88246826
127intra-S DNA damage checkpoint (GO:0031573)2.87213431
128polyol catabolic process (GO:0046174)2.85289572
129response to acidic pH (GO:0010447)2.83864911
130peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82742117
131RNA localization (GO:0006403)2.80968591
132alditol metabolic process (GO:0019400)2.78001354
133RNA destabilization (GO:0050779)2.76163425
134erythrocyte development (GO:0048821)2.75953012
135regulation of phosphatase activity (GO:0010921)2.75813635
136regulation of cofactor metabolic process (GO:0051193)2.74570865
137synapsis (GO:0007129)2.73388566
138GTP biosynthetic process (GO:0006183)2.72863018
139meiotic cell cycle process (GO:1903046)2.67965384
140cilium organization (GO:0044782)2.66614952
141regulation of cilium assembly (GO:1902017)2.64002918
142cellular component assembly involved in morphogenesis (GO:0010927)2.61378289
143microtubule-based movement (GO:0007018)2.56970340
144cilium assembly (GO:0042384)2.55273921
145mitochondrion degradation (GO:0000422)2.55122862
146cilium morphogenesis (GO:0060271)2.53785300
147peptidyl-glutamic acid modification (GO:0018200)2.45937992
148intraciliary transport (GO:0042073)2.44574992
149axoneme assembly (GO:0035082)2.43910333
150UTP biosynthetic process (GO:0006228)2.42808039
151nucleosome disassembly (GO:0006337)2.42093580
152protein-DNA complex disassembly (GO:0032986)2.42093580
153negative regulation of organelle assembly (GO:1902116)2.40309922
154cell wall macromolecule catabolic process (GO:0016998)14.4297042
155cell wall macromolecule metabolic process (GO:0044036)14.4297042
156sperm motility (GO:0030317)14.2182074
157fusion of sperm to egg plasma membrane (GO:0007342)12.9583552
158acrosome reaction (GO:0007340)12.5543818
159acrosome assembly (GO:0001675)12.3432634
160sperm-egg recognition (GO:0035036)11.8978350
161binding of sperm to zona pellucida (GO:0007339)10.7909666
162multicellular organism reproduction (GO:0032504)10.7707604
163cell-cell recognition (GO:0009988)10.6606330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.97646822
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.08313316
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.07291088
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.10096172
5IGF1R_20145208_ChIP-Seq_DFB_Human4.08073699
6EZH2_22144423_ChIP-Seq_EOC_Human3.91792188
7E2F7_22180533_ChIP-Seq_HELA_Human3.67050384
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13905918
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.12834479
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08143569
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92589146
12GATA1_22025678_ChIP-Seq_K562_Human2.90525412
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.85244340
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83095579
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83025215
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73925442
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.54834235
18VDR_22108803_ChIP-Seq_LS180_Human2.52319162
19AR_21909140_ChIP-Seq_LNCAP_Human2.40333922
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.27060528
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23595009
22ZNF274_21170338_ChIP-Seq_K562_Hela2.09446075
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06999567
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06468803
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05067660
26ER_23166858_ChIP-Seq_MCF-7_Human1.97726059
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.96132336
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92009956
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91592239
30FUS_26573619_Chip-Seq_HEK293_Human1.82835685
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78818805
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74494789
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73060122
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.72433261
35STAT1_17558387_ChIP-Seq_HELA_Human1.70641055
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.70319297
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67422532
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67372397
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.66767580
40RAC3_21632823_ChIP-Seq_H3396_Human1.65854349
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65792530
42GBX2_23144817_ChIP-Seq_PC3_Human1.65388897
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65162792
44ERA_21632823_ChIP-Seq_H3396_Human1.64818681
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.64060792
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60605397
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58162630
48TBL1_22424771_ChIP-Seq_293T_Human1.55180144
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55117280
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50711326
51NANOG_20526341_ChIP-Seq_ESCs_Human1.48591719
52KDM2B_26808549_Chip-Seq_REH_Human1.48203768
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46011252
54FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45921336
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43867321
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.43438626
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.42575677
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.41806161
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40754077
60OCT1_27270436_Chip-Seq_PROSTATE_Human1.39732754
61LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39138367
62CBP_20019798_ChIP-Seq_JUKART_Human1.38719581
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38719581
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38551729
65P53_21459846_ChIP-Seq_SAOS-2_Human1.37877037
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36754953
67AR_21572438_ChIP-Seq_LNCaP_Human1.36652675
68PHF8_20622853_ChIP-Seq_HELA_Human1.36529389
69OCT4_20526341_ChIP-Seq_ESCs_Human1.35289576
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34132606
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32698316
72REST_21632747_ChIP-Seq_MESCs_Mouse1.32190323
73GATA3_21867929_ChIP-Seq_TH1_Mouse1.31144382
74NFYB_21822215_ChIP-Seq_K562_Human1.30966832
75GATA1_19941826_ChIP-Seq_K562_Human1.28533913
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28372428
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.26943369
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.26834341
79GF1_26923725_Chip-Seq_HPCs_Mouse1.25860637
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25103856
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25017379
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23977587
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23385579
84MYC_18940864_ChIP-ChIP_HL60_Human1.23189251
85RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22804949
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22633328
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22505332
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21692288
89CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21192166
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21041010
91SPI1_23127762_ChIP-Seq_K562_Human1.21000373
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.20430948
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.20163453
94SPI1_26923725_Chip-Seq_HPCs_Mouse1.19293140
95NCOR1_26117541_ChIP-Seq_K562_Human1.19168668
96P300_19829295_ChIP-Seq_ESCs_Human1.18760312
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18656747
98IRF1_19129219_ChIP-ChIP_H3396_Human1.18557690
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18250638
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17118882
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16923001
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16177977
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15858415
104CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14683043
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.14391318
106BCAT_22108803_ChIP-Seq_LS180_Human1.13909170
107ELF5_23300383_ChIP-Seq_T47D_Human1.13514512
108ETV1_20927104_ChIP-Seq_GIST48_Human1.13098426
109GATA2_19941826_ChIP-Seq_K562_Human1.11955390
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11890626
111SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11426447
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11222312
113RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11152354
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.10956194
115RBPJ_21746931_ChIP-Seq_IB4_Human1.10874650
116GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10868148
117KDM5A_27292631_Chip-Seq_BREAST_Human1.10613289
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10573808
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10573808
120AHR_22903824_ChIP-Seq_MCF-7_Human1.09799068
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09419041
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.09247104
123RUNX2_22187159_ChIP-Seq_PCA_Human1.09137070
124GATA6_21074721_ChIP-Seq_CACO-2_Human1.09051464
125ELK1_19687146_ChIP-ChIP_HELA_Human1.09047976
126ESET_19884257_ChIP-Seq_ESCs_Mouse1.08620695
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08500317
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08454111
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.07983678
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.07737690
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07712854
132HOXB7_26014856_ChIP-Seq_BT474_Human1.07526274
133SOX2_19829295_ChIP-Seq_ESCs_Human1.07074217
134NANOG_19829295_ChIP-Seq_ESCs_Human1.07074217
135ERG_20517297_ChIP-Seq_VCAP_Human1.07000889
136FOXH1_21741376_ChIP-Seq_EPCs_Human1.06779153
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06713669
138NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06120194
139CRX_20693478_ChIP-Seq_RETINA_Mouse1.06030460
140GABP_19822575_ChIP-Seq_HepG2_Human1.05821521
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05812336
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.04892518
143MYC_19829295_ChIP-Seq_ESCs_Human1.04006802
144YY1_22570637_ChIP-Seq_MALME-3M_Human1.03884271
145JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03684933
146EWS_26573619_Chip-Seq_HEK293_Human1.03354375
147E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03231158
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.03106049
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02732762
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02224397
151NFYA_21822215_ChIP-Seq_K562_Human1.02060793
152LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01187421
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00591075
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00532188
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00166258
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99671847
157SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99374715
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.99039140
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97878911
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97867238
161DCP1A_22483619_ChIP-Seq_HELA_Human0.96136667
162SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95325389
163P53_22387025_ChIP-Seq_ESCs_Mouse0.95239694
164KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94764784
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.94440013
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.93631140
167PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93612850
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.93195226
169CTCF_20526341_ChIP-Seq_ESCs_Human0.92951550
170KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92742044
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92664749
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92578191
173ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92572051
174GATA3_21878914_ChIP-Seq_MCF-7_Human0.91895855
175TAF15_26573619_Chip-Seq_HEK293_Human0.91874883
176BCOR_27268052_Chip-Seq_Bcells_Human0.91813902
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90015592
178SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89249216
179KLF4_18555785_Chip-Seq_ESCs_Mouse0.88942293
180P300_18555785_Chip-Seq_ESCs_Mouse0.88248839
181OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88215127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08059275
2MP0001929_abnormal_gametogenesis5.57883921
3MP0003315_abnormal_perineum_morphology5.16096294
4MP0008004_abnormal_stomach_pH4.82771635
5MP0008877_abnormal_DNA_methylation3.81421433
6MP0009697_abnormal_copulation3.71742083
7MP0002161_abnormal_fertility/fecundity3.30718621
8MP0002210_abnormal_sex_determination3.29604747
9MP0005670_abnormal_white_adipose2.99330265
10MP0005360_urolithiasis2.95315601
11MP0001145_abnormal_male_reproductive2.82109959
12MP0003693_abnormal_embryo_hatching2.48893936
13MP0000653_abnormal_sex_gland2.43738071
14MP0003806_abnormal_nucleotide_metabolis2.27398840
15MP0002653_abnormal_ependyma_morphology2.10306654
16MP0005410_abnormal_fertilization16.7861405
17MP0003136_yellow_coat_color1.94208672
18MP0005187_abnormal_penis_morphology1.94005021
19MP0003718_maternal_effect1.78963867
20MP0001661_extended_life_span1.64765904
21MP0000749_muscle_degeneration1.63815642
22MP0000678_abnormal_parathyroid_gland1.60930978
23MP0004233_abnormal_muscle_weight1.58242275
24MP0003646_muscle_fatigue1.54632153
25MP0004957_abnormal_blastocyst_morpholog1.48370357
26MP0002160_abnormal_reproductive_system1.47062710
27MP0003045_fibrosis1.45646938
28MP0005058_abnormal_lysosome_morphology1.44555019
29MP0005499_abnormal_olfactory_system1.43198032
30MP0005394_taste/olfaction_phenotype1.43198032
31MP0006072_abnormal_retinal_apoptosis1.38684673
32MP0005623_abnormal_meninges_morphology1.32522987
33MP0008057_abnormal_DNA_replication1.30417547
34MP0000537_abnormal_urethra_morphology1.27408522
35MP0005646_abnormal_pituitary_gland1.26998897
36MP0001529_abnormal_vocalization1.23415640
37MP0004272_abnormal_basement_membrane1.16425106
38MP0004147_increased_porphyrin_level1.15568951
39MP0002127_abnormal_cardiovascular_syste1.13700070
40MP0003077_abnormal_cell_cycle1.13388438
41MP0003936_abnormal_reproductive_system1.12337094
42MP0001765_abnormal_ion_homeostasis1.09579730
43MP0001984_abnormal_olfaction1.09149700
44MP0003385_abnormal_body_wall1.08174662
45MP0002234_abnormal_pharynx_morphology1.07905407
46MP0002282_abnormal_trachea_morphology1.04936288
47MP0001664_abnormal_digestion1.04555034
48MP0005171_absent_coat_pigmentation0.98498410
49MP0010386_abnormal_urinary_bladder0.96994631
50MP0010368_abnormal_lymphatic_system0.96195123
51MP0008932_abnormal_embryonic_tissue0.95799689
52MP0004085_abnormal_heartbeat0.93055645
53MP0008058_abnormal_DNA_repair0.89241830
54MP0009046_muscle_twitch0.88542035
55MP0005395_other_phenotype0.88201527
56MP0000372_irregular_coat_pigmentation0.87807635
57MP0008007_abnormal_cellular_replicative0.82343517
58MP0002837_dystrophic_cardiac_calcinosis0.80533060
59MP0005647_abnormal_sex_gland0.79959445
60MP0008872_abnormal_physiological_respon0.79758738
61MP0008775_abnormal_heart_ventricle0.78792842
62MP0005083_abnormal_biliary_tract0.75732423
63MP0000631_abnormal_neuroendocrine_gland0.75159503
64MP0002249_abnormal_larynx_morphology0.75057764
65MP0000747_muscle_weakness0.74286838
66MP0005389_reproductive_system_phenotype0.72214783
67MP0003890_abnormal_embryonic-extraembry0.72082746
68MP0001697_abnormal_embryo_size0.71972792
69MP0008789_abnormal_olfactory_epithelium0.70578899
70MP0002233_abnormal_nose_morphology0.68052489
71MP0001919_abnormal_reproductive_system0.67969607
72MP0003786_premature_aging0.67934113
73MP0004264_abnormal_extraembryonic_tissu0.66894289
74MP0001188_hyperpigmentation0.66005014
75MP0003011_delayed_dark_adaptation0.65488906
76MP0003115_abnormal_respiratory_system0.64859639
77MP0003938_abnormal_ear_development0.64635508
78MP0001905_abnormal_dopamine_level0.64629359
79MP0000538_abnormal_urinary_bladder0.62865709
80MP0005636_abnormal_mineral_homeostasis0.62521466
81MP0002086_abnormal_extraembryonic_tissu0.61977413
82MP0003119_abnormal_digestive_system0.61311192
83MP0005620_abnormal_muscle_contractility0.58862037
84MP0004036_abnormal_muscle_relaxation0.58269140
85MP0004782_abnormal_surfactant_physiolog0.57477006
86MP0003329_amyloid_beta_deposits0.57466792
87MP0005666_abnormal_adipose_tissue0.54166406
88MP0000681_abnormal_thyroid_gland0.54060250
89MP0001502_abnormal_circadian_rhythm0.53976055
90MP0004215_abnormal_myocardial_fiber0.53822227
91MP0002736_abnormal_nociception_after0.53736680
92MP0002080_prenatal_lethality0.52814873
93MP0008995_early_reproductive_senescence0.51952838
94MP0001324_abnormal_eye_pigmentation0.49481677
95MP0002269_muscular_atrophy0.49472536
96MP0001764_abnormal_homeostasis0.49003119
97MP0006036_abnormal_mitochondrial_physio0.48526706
98MP0003878_abnormal_ear_physiology0.46617119
99MP0005377_hearing/vestibular/ear_phenot0.46617119
100MP0003699_abnormal_female_reproductive0.45842898
101MP0001293_anophthalmia0.43983230
102MP0000358_abnormal_cell_content/0.43316487
103MP0002928_abnormal_bile_duct0.39466709
104MP0004133_heterotaxia0.39440009
105MP0000534_abnormal_ureter_morphology0.39385270
106MP0001545_abnormal_hematopoietic_system0.38588682
107MP0005397_hematopoietic_system_phenotyp0.38588682
108MP0005253_abnormal_eye_physiology0.37842416
109MP0010094_abnormal_chromosome_stability0.36149553
110MP0005551_abnormal_eye_electrophysiolog0.35959284
111MP0009115_abnormal_fat_cell0.33647706
112MP0003633_abnormal_nervous_system0.32847296
113MP0009278_abnormal_bone_marrow0.32524820
114MP0002139_abnormal_hepatobiliary_system0.32429389
115MP0003950_abnormal_plasma_membrane0.32408417
116MP0000569_abnormal_digit_pigmentation0.31939472
117MP0001968_abnormal_touch/_nociception0.30795646
118MP0004811_abnormal_neuron_physiology0.30612545
119MP0000604_amyloidosis0.29925282
120MP0005391_vision/eye_phenotype0.27868165
121MP0001730_embryonic_growth_arrest0.26342021
122MP0003942_abnormal_urinary_system0.25893364
123MP0004019_abnormal_vitamin_homeostasis0.25856027
124MP0002971_abnormal_brown_adipose0.25325364
125MP0003631_nervous_system_phenotype0.25163380
126MP0002169_no_abnormal_phenotype0.24499871
127MP0002873_normal_phenotype0.24276792
128MP0002102_abnormal_ear_morphology0.23945227
129MP0001119_abnormal_female_reproductive0.23637449
130MP0003861_abnormal_nervous_system0.23451992
131MP0006035_abnormal_mitochondrial_morpho0.23062068
132MP0003111_abnormal_nucleus_morphology0.22322692
133MP0004145_abnormal_muscle_electrophysio0.21890276
134MP0002152_abnormal_brain_morphology0.21659386
135MP0003948_abnormal_gas_homeostasis0.21295843
136MP0008875_abnormal_xenobiotic_pharmacok0.20813158
137MP0003787_abnormal_imprinting0.20180749
138MP0003879_abnormal_hair_cell0.19816009
139MP0002295_abnormal_pulmonary_circulatio0.16790519
140MP0004742_abnormal_vestibular_system0.16449677
141MP0001849_ear_inflammation0.16229899
142MP0004043_abnormal_pH_regulation0.15957407
143MP0002909_abnormal_adrenal_gland0.15955282
144MP0005319_abnormal_enzyme/_coenzyme0.15793867
145MP0004084_abnormal_cardiac_muscle0.15768905
146MP0008569_lethality_at_weaning0.14736745
147MP0010307_abnormal_tumor_latency0.14597924
148MP0000001_mammalian_phenotype0.14587196
149MP0000462_abnormal_digestive_system0.14438925
150MP0002229_neurodegeneration0.14397626
151MP0004270_analgesia0.14284591
152MP0005365_abnormal_bile_salt0.13987349
153MP0002092_abnormal_eye_morphology0.13436544
154MP0002132_abnormal_respiratory_system0.13325846
155MP0005375_adipose_tissue_phenotype0.13184992
156MP0000313_abnormal_cell_death0.13093212
157MP0002693_abnormal_pancreas_physiology0.12857499
158MP0002118_abnormal_lipid_homeostasis0.11702010
159MP0002084_abnormal_developmental_patter0.11692288
160MP0005195_abnormal_posterior_eye0.11511709
161MP0000751_myopathy0.11499768
162MP0003959_abnormal_lean_body0.11388484
163MP0001348_abnormal_lacrimal_gland0.10110703

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.45572196
2Abnormal respiratory motile cilium morphology (HP:0005938)9.18520333
3Abnormal respiratory epithelium morphology (HP:0012253)9.18520333
4Chronic bronchitis (HP:0004469)7.51390933
5Rhinitis (HP:0012384)7.51012126
6Abnormal ciliary motility (HP:0012262)7.44325923
7Infertility (HP:0000789)7.03546981
8Nasal polyposis (HP:0100582)6.49045418
9Abnormality of the nasal mucosa (HP:0000433)5.34066199
10Resting tremor (HP:0002322)5.08663394
11Short middle phalanx of the 5th finger (HP:0004220)5.03363096
12Male infertility (HP:0003251)4.89457456
13Bronchitis (HP:0012387)4.62165965
14Facial hemangioma (HP:0000329)4.53955007
15Hypoplasia of the uterus (HP:0000013)4.42526194
16Bronchiectasis (HP:0002110)4.42000232
17Reduced antithrombin III activity (HP:0001976)4.38110059
18Abnormality of the columella (HP:0009929)4.35429674
19Sex reversal (HP:0012245)4.24735796
20Abnormal sex determination (HP:0012244)4.24735796
21Nephronophthisis (HP:0000090)4.00769141
22Abnormal spermatogenesis (HP:0008669)3.79307892
23Abnormality of the intrinsic pathway (HP:0010989)3.78926661
24Protruding tongue (HP:0010808)3.71980392
25Ventricular fibrillation (HP:0001663)3.64900281
26Acanthocytosis (HP:0001927)3.60159851
27Gonadal dysgenesis (HP:0000133)3.55880546
28Postural instability (HP:0002172)3.42244624
29Reticulocytosis (HP:0001923)3.37121304
30Recurrent otitis media (HP:0000403)3.29212634
31Recurrent sinusitis (HP:0011108)3.28799307
32Capillary hemangiomas (HP:0005306)3.26767696
33Aplasia/hypoplasia of the uterus (HP:0008684)3.17856293
34Poikilocytosis (HP:0004447)3.09147243
35Male pseudohermaphroditism (HP:0000037)3.08325885
36Abnormality of the renal medulla (HP:0100957)2.97635807
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.97324471
38Abnormal protein N-linked glycosylation (HP:0012347)2.97324471
39Abnormal protein glycosylation (HP:0012346)2.97324471
40Abnormal glycosylation (HP:0012345)2.97324471
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.94678134
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87934526
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.87595225
44Chromsome breakage (HP:0040012)2.87087774
45Polycythemia (HP:0001901)2.86864653
46Truncus arteriosus (HP:0001660)2.73879067
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.71575267
48Recurrent bronchitis (HP:0002837)2.69349319
49Small intestinal stenosis (HP:0012848)2.66876987
50Duodenal stenosis (HP:0100867)2.66876987
51Molar tooth sign on MRI (HP:0002419)2.64559409
52Abnormality of midbrain morphology (HP:0002418)2.64559409
53Tubulointerstitial nephritis (HP:0001970)2.60017828
54Tubular atrophy (HP:0000092)2.59907788
55Ileus (HP:0002595)2.57480909
56Colitis (HP:0002583)2.55428419
57Medial flaring of the eyebrow (HP:0010747)2.53594755
58Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.52513645
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51468491
60Abnormality of the ileum (HP:0001549)2.51173063
61Impulsivity (HP:0100710)2.49280532
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.48685472
63Unsteady gait (HP:0002317)2.46483478
64Abnormality of reticulocytes (HP:0004312)2.44287634
65Azoospermia (HP:0000027)2.42934087
66Abnormal gallbladder physiology (HP:0012438)2.42186771
67Cholecystitis (HP:0001082)2.42186771
68Tubulointerstitial abnormality (HP:0001969)2.38185015
69Abnormality of cochlea (HP:0000375)2.37109103
70Hypothermia (HP:0002045)2.35948411
71Hypoplastic iliac wings (HP:0002866)2.32092912
72Urinary urgency (HP:0000012)2.32069797
73Meckel diverticulum (HP:0002245)2.31900285
74Type I transferrin isoform profile (HP:0003642)2.27337608
75Duplicated collecting system (HP:0000081)2.25828517
76Upper limb muscle weakness (HP:0003484)2.25646450
77Abnormality of chromosome stability (HP:0003220)2.24035571
78Abnormality of the phalanges of the 5th finger (HP:0004213)2.21394815
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20804124
80Abnormality of the preputium (HP:0100587)2.20703404
81Abnormality of dental color (HP:0011073)2.20340138
82Self-mutilation (HP:0000742)2.19248833
83Dyschromatopsia (HP:0007641)2.17021409
84Absent thumb (HP:0009777)2.16756701
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14285306
86Atonic seizures (HP:0010819)2.13171316
87Nonimmune hydrops fetalis (HP:0001790)2.09506480
88Abnormality of the renal collecting system (HP:0004742)2.08410348
89Tubulointerstitial fibrosis (HP:0005576)2.04814220
90Abnormality of the duodenum (HP:0002246)2.03882984
91Gonadotropin excess (HP:0000837)2.03493899
92Abnormality of DNA repair (HP:0003254)2.02607360
93Short 5th finger (HP:0009237)2.01644619
94Decreased central vision (HP:0007663)2.00592765
95Dynein arm defect of respiratory motile cilia (HP:0012255)13.2941213
96Absent/shortened dynein arms (HP:0200106)13.2941213
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2200831
98Congenital malformation of the right heart (HP:0011723)1.97983807
99Double outlet right ventricle (HP:0001719)1.97983807
100Abnormality of the frontal sinuses (HP:0002687)1.96215557
101Germ cell neoplasia (HP:0100728)1.95256625
102Ureteral duplication (HP:0000073)1.93379724
103Sloping forehead (HP:0000340)1.93361023
104Choroideremia (HP:0001139)1.93052514
105Hyperthyroidism (HP:0000836)1.91345796
106Type II lissencephaly (HP:0007260)1.91265379
107Ectopic kidney (HP:0000086)1.89363064
108Thoracic kyphosis (HP:0002942)1.88171084
109Optic nerve hypoplasia (HP:0000609)1.85806849
110Cerebral hypomyelination (HP:0006808)1.85193997
111Pancreatic islet-cell hyperplasia (HP:0004510)1.84169823
112Polydipsia (HP:0001959)1.83033249
113Abnormal drinking behavior (HP:0030082)1.83033249
114Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81444483
115Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80220000
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.77485463
117Spastic tetraparesis (HP:0001285)1.76858687
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76355498
119Clubbing of toes (HP:0100760)1.75666658
120Enlarged kidneys (HP:0000105)1.75647279
121Abnormal rod and cone electroretinograms (HP:0008323)1.75092062
122High anterior hairline (HP:0009890)1.74451301
123Diaphragmatic weakness (HP:0009113)1.73755652
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73464062
125Abnormality of the carotid arteries (HP:0005344)1.73391210
126Postaxial foot polydactyly (HP:0001830)1.72969815
127Morphological abnormality of the inner ear (HP:0011390)1.72260679
128Abnormal lung lobation (HP:0002101)1.72195296
129Squamous cell carcinoma (HP:0002860)1.70280007
130Hemorrhage of the eye (HP:0011885)1.69213531
131Stage 5 chronic kidney disease (HP:0003774)1.68781398
132Congenital hepatic fibrosis (HP:0002612)1.67837814
133Abnormality of renal excretion (HP:0011036)1.67668187
134Bile duct proliferation (HP:0001408)1.63998842
135Abnormal biliary tract physiology (HP:0012439)1.63998842
136Neurofibrillary tangles (HP:0002185)1.62938409
137Aplasia/Hypoplasia of the lens (HP:0008063)1.57750551
138Abnormality of the renal cortex (HP:0011035)1.57519261
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.56109737
140Heterotopia (HP:0002282)1.53657961
141Asymmetric septal hypertrophy (HP:0001670)1.52702235
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52454226
143Exercise-induced myalgia (HP:0003738)1.51422498
144Oculomotor apraxia (HP:0000657)1.48178073
145Short ribs (HP:0000773)1.48002724
146Easy fatigability (HP:0003388)1.44828215
147Bundle branch block (HP:0011710)1.44037966
148Postaxial hand polydactyly (HP:0001162)1.41924743
149Abnormal urine output (HP:0012590)1.41782000
150Renal dysplasia (HP:0000110)1.41170261
151Facial cleft (HP:0002006)1.39157951
152Chronic sinusitis (HP:0011109)1.38144428
153Bell-shaped thorax (HP:0001591)1.38051291
154Myoglobinuria (HP:0002913)1.37926824
155Abnormality of the dental root (HP:0006486)1.37702859
156Taurodontia (HP:0000679)1.37702859
157Abnormality of permanent molar morphology (HP:0011071)1.37702859
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.36565115
159Constricted visual fields (HP:0001133)1.35806091
160Abnormality of saccadic eye movements (HP:0000570)1.35512837
161Gait imbalance (HP:0002141)1.35497552
162Congenital primary aphakia (HP:0007707)1.35460013
163Fibular hypoplasia (HP:0003038)1.34696054
164Abnormality of the neuromuscular junction (HP:0003398)1.34170832
165Fatigable weakness (HP:0003473)1.34170832
166Cystic liver disease (HP:0006706)1.33485349
167Sensory axonal neuropathy (HP:0003390)1.32042192
168Cerebral inclusion bodies (HP:0100314)1.30978960
169Pancreatic fibrosis (HP:0100732)1.30800167
170Cerebellar dysplasia (HP:0007033)1.30082288
171Abnormality of dentin (HP:0010299)1.29809790
172Abnormality of the dental pulp (HP:0006479)1.29340606
173Deformed sella turcica (HP:0002681)1.29140549
174Abnormality of molar (HP:0011077)1.26895521
175Abnormality of molar morphology (HP:0011070)1.26895521
176Rhabdomyolysis (HP:0003201)1.24395778
177Exercise-induced muscle cramps (HP:0003710)1.23857691
178Loss of speech (HP:0002371)1.21503144
179Hypercholesterolemia (HP:0003124)1.20088031
180Abnormality of ocular smooth pursuit (HP:0000617)1.19543057
181Absent epiphyses (HP:0010577)1.19206110
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.19206110
183Polyuria (HP:0000103)1.18016935
184Abnormality of the lower motor neuron (HP:0002366)1.14609390
185Nephropathy (HP:0000112)1.14439847
186Microglossia (HP:0000171)1.14283028
187Retinal dysplasia (HP:0007973)1.14056820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.13158171
2PDK38.13158171
3TESK16.58780759
4PDK25.26117263
5PRKD34.86345491
6ICK4.56849835
7ZAK2.84021533
8MYLK2.31238505
9PTK2B2.30780734
10WNK42.18375790
11TLK12.15385957
12STK392.13070076
13RPS6KA52.01487756
14STK381.99396565
15LATS11.61956030
16DYRK1B1.59036500
17NEK21.54988462
18EIF2AK31.54454921
19PNCK1.45066610
20OBSCN1.43236461
21PDK11.33982227
22CDK121.33557740
23TNIK1.32043279
24BUB11.26328808
25FRK1.22058987
26TRIM281.17320774
27PKN21.13999476
28CDK81.13045325
29BMPR1B1.09616307
30KSR21.04712761
31RET1.03023340
32CDK31.02743460
33MST40.99947376
34AKT30.99829657
35DYRK30.92915829
36PBK0.90716920
37PDPK10.89664755
38IRAK10.86252718
39LATS20.85281654
40TRPM70.84452252
41TYRO30.84183924
42EIF2AK10.83519181
43RIPK40.82142497
44RAF10.78557997
45MAPK150.78488193
46WNK10.74720351
47EEF2K0.72142754
48MAP3K20.71947773
49CCNB10.71791561
50MAP4K20.68452568
51PASK0.67049671
52ROCK10.63730289
53TESK20.62388312
54SRPK10.60913874
55PINK10.60676303
56CHEK20.59552500
57SGK2230.59335901
58SGK4940.59335901
59TTK0.59327418
60STK40.58650531
61MAP3K80.57349944
62STK30.56477114
63LMTK20.56127285
64STK38L0.55984035
65NTRK30.55697593
66MAP2K60.53168238
67BRD40.52408504
68CSNK1A1L0.51809743
69NME20.50356947
70AURKB0.50338232
71VRK10.49626305
72MUSK0.49058366
73KSR10.48457707
74IRAK20.48380198
75ARAF0.46104816
76NTRK20.44874985
77BMPR20.42689403
78PRKCG0.41511736
79NLK0.41021385
80CSNK1G10.38858434
81PAK10.38844620
82MAP3K100.38499829
83DYRK20.37877616
84MELK0.37645395
85FGR0.36643318
86ACVR1B0.34770025
87CHEK10.34526705
88NEK10.34222590
89BRSK20.33815827
90CSNK1G30.33226757
91PLK30.32384977
92CAMK1G0.30966755
93CAMK10.30741407
94MAPK130.30549809
95MAPKAPK50.30419585
96TGFBR10.30161015
97NME10.30080248
98JAK20.29366458
99MST1R0.28317119
100RPS6KA40.28155781
101PLK20.27254599
102CDK50.25747781
103PAK20.24357447
104MARK20.24242892
105CAMKK10.24103928
106WEE10.23505035
107PAK40.22845051
108ATM0.22773118
109PRKCZ0.22506513
110PLK40.20090334
111CDK150.19733177
112ATR0.19532359
113PRKCQ0.18756795
114BRSK10.18712063
115MTOR0.18528621
116PRKG20.17619558
117CDK180.16945954
118PRKAA10.16142915
119CDK11A0.15529933
120NEK60.14443018
121RPS6KB10.13673537
122BRAF0.13521769
123CDK140.11464123
124STK100.10917779
125PLK10.10586101
126CSF1R0.10155424
127MARK30.09903835
128RPS6KA10.09217929
129CSNK2A10.08318554
130PRKCD0.06700594
131GSK3B0.05816007
132ZAP700.05550164
133STK110.04738516
134PKN10.04411136
135CAMK2A0.04250716
136PRKACG0.03941474
137CDC70.03922233
138PRKG10.03818659
139PIM10.03412037
140MAPK80.02740217
141CSNK2A20.02421280
142MAP3K40.02148372
143PRKCA0.02106098
144AURKA0.01603676
145CLK10.01551911
146PRKCB0.01538268
147PDGFRB0.01384973
148CDK10.01287394
149CDK60.01286357
150CDK20.01185724
151PAK6-0.0499192
152PRKACB-0.0433810
153RPS6KA3-0.0367013
154MAP3K1-0.0333387
155PRKACA-0.0318491
156YES1-0.0287931
157CSNK1D-0.0272230
158MAP3K5-0.0238432
159EGFR-0.0113965
160MAP2K7-0.0075199

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.86039874
2Fatty acid biosynthesis_Homo sapiens_hsa000614.76432284
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46479661
4Nitrogen metabolism_Homo sapiens_hsa009104.17450433
5Gap junction_Homo sapiens_hsa045403.67520854
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56191984
7Vitamin B6 metabolism_Homo sapiens_hsa007503.41423807
8Pyruvate metabolism_Homo sapiens_hsa006203.33696844
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26559879
10Linoleic acid metabolism_Homo sapiens_hsa005913.19146953
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84880136
12Olfactory transduction_Homo sapiens_hsa047402.70206303
13Propanoate metabolism_Homo sapiens_hsa006402.56633667
14Glucagon signaling pathway_Homo sapiens_hsa049222.55829262
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.35087081
16Basal transcription factors_Homo sapiens_hsa030222.29205022
17Butanoate metabolism_Homo sapiens_hsa006502.22933255
18Apoptosis_Homo sapiens_hsa042102.16420395
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08661878
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98644124
21Arginine biosynthesis_Homo sapiens_hsa002201.97207183
22Glycerolipid metabolism_Homo sapiens_hsa005611.92161339
23Selenocompound metabolism_Homo sapiens_hsa004501.88320355
24One carbon pool by folate_Homo sapiens_hsa006701.87275054
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84532615
26PPAR signaling pathway_Homo sapiens_hsa033201.84344591
27Pentose phosphate pathway_Homo sapiens_hsa000301.84100252
28Mismatch repair_Homo sapiens_hsa034301.80995909
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.77541639
30Fat digestion and absorption_Homo sapiens_hsa049751.67078486
31Fructose and mannose metabolism_Homo sapiens_hsa000511.59866143
32RNA degradation_Homo sapiens_hsa030181.58889589
33Mineral absorption_Homo sapiens_hsa049781.58253388
34Homologous recombination_Homo sapiens_hsa034401.58221428
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58102973
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57861199
37Oocyte meiosis_Homo sapiens_hsa041141.54034740
38DNA replication_Homo sapiens_hsa030301.52827700
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52735479
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.52186811
41Amphetamine addiction_Homo sapiens_hsa050311.52081702
42Ether lipid metabolism_Homo sapiens_hsa005651.50983860
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48238215
44Fatty acid degradation_Homo sapiens_hsa000711.45409676
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.44554720
46Carbon metabolism_Homo sapiens_hsa012001.43884381
47Fatty acid metabolism_Homo sapiens_hsa012121.42727261
48Phagosome_Homo sapiens_hsa041451.37780844
49Cardiac muscle contraction_Homo sapiens_hsa042601.36574308
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34038187
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25800546
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19419243
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18951382
54Nucleotide excision repair_Homo sapiens_hsa034201.16762951
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10129713
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.08935301
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08595183
58Glutathione metabolism_Homo sapiens_hsa004801.08451987
59Cell cycle_Homo sapiens_hsa041101.06722648
60Renin secretion_Homo sapiens_hsa049241.04388890
61Dorso-ventral axis formation_Homo sapiens_hsa043201.04218111
62Fanconi anemia pathway_Homo sapiens_hsa034601.03604630
63Collecting duct acid secretion_Homo sapiens_hsa049661.02317919
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02145320
65Antigen processing and presentation_Homo sapiens_hsa046120.99861740
66Purine metabolism_Homo sapiens_hsa002300.99013366
67Parkinsons disease_Homo sapiens_hsa050120.94378984
68Biosynthesis of amino acids_Homo sapiens_hsa012300.93514272
69Hedgehog signaling pathway_Homo sapiens_hsa043400.92135459
70Huntingtons disease_Homo sapiens_hsa050160.88238638
71Chemical carcinogenesis_Homo sapiens_hsa052040.87155289
72Insulin secretion_Homo sapiens_hsa049110.86814896
73Arachidonic acid metabolism_Homo sapiens_hsa005900.86666210
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84023651
75Renin-angiotensin system_Homo sapiens_hsa046140.82968363
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.82382817
77mRNA surveillance pathway_Homo sapiens_hsa030150.79068743
78Bile secretion_Homo sapiens_hsa049760.76765779
79Thyroid hormone synthesis_Homo sapiens_hsa049180.75969043
80Long-term potentiation_Homo sapiens_hsa047200.73822891
81Estrogen signaling pathway_Homo sapiens_hsa049150.70104248
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68670508
83Systemic lupus erythematosus_Homo sapiens_hsa053220.67641717
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65782117
85Steroid biosynthesis_Homo sapiens_hsa001000.65697025
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65053517
87RNA polymerase_Homo sapiens_hsa030200.62036877
88Pancreatic secretion_Homo sapiens_hsa049720.60463055
89Non-homologous end-joining_Homo sapiens_hsa034500.59022280
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57338063
91RNA transport_Homo sapiens_hsa030130.57047262
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.56009559
93Legionellosis_Homo sapiens_hsa051340.55223491
94Salivary secretion_Homo sapiens_hsa049700.52996264
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52934020
96Synaptic vesicle cycle_Homo sapiens_hsa047210.52605197
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52265745
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51273844
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51220075
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.51105432
101Retinol metabolism_Homo sapiens_hsa008300.49036270
102Spliceosome_Homo sapiens_hsa030400.48842188
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48639480
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.48233232
105Calcium signaling pathway_Homo sapiens_hsa040200.47491436
106Circadian rhythm_Homo sapiens_hsa047100.46977138
107Protein digestion and absorption_Homo sapiens_hsa049740.46669907
108Sulfur metabolism_Homo sapiens_hsa009200.46310389
109Endocytosis_Homo sapiens_hsa041440.44293705
110ABC transporters_Homo sapiens_hsa020100.43428964
111AMPK signaling pathway_Homo sapiens_hsa041520.42830464
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42740756
113Gastric acid secretion_Homo sapiens_hsa049710.42316646
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41990372
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41569180
116TGF-beta signaling pathway_Homo sapiens_hsa043500.40633365
117Metabolic pathways_Homo sapiens_hsa011000.38852711
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38751531
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37024621
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36705210
121Regulation of autophagy_Homo sapiens_hsa041400.35566464
122Inositol phosphate metabolism_Homo sapiens_hsa005620.35102219
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34963553
124Alcoholism_Homo sapiens_hsa050340.33767906
125VEGF signaling pathway_Homo sapiens_hsa043700.31543891
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29861527
127cAMP signaling pathway_Homo sapiens_hsa040240.28608532
128Arginine and proline metabolism_Homo sapiens_hsa003300.27812417
129Tyrosine metabolism_Homo sapiens_hsa003500.27732156
130Choline metabolism in cancer_Homo sapiens_hsa052310.27722261
131Proteasome_Homo sapiens_hsa030500.27563806
132Pyrimidine metabolism_Homo sapiens_hsa002400.26814833
133Type II diabetes mellitus_Homo sapiens_hsa049300.26479665
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26056273
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24111377
136Taste transduction_Homo sapiens_hsa047420.24002099
137Phenylalanine metabolism_Homo sapiens_hsa003600.23538066
138Cocaine addiction_Homo sapiens_hsa050300.22888811
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21871311
140Lysine degradation_Homo sapiens_hsa003100.21168506
141Circadian entrainment_Homo sapiens_hsa047130.21091094
142mTOR signaling pathway_Homo sapiens_hsa041500.20077936
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19102231
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17828516
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16671854
146Salmonella infection_Homo sapiens_hsa051320.15240478
147B cell receptor signaling pathway_Homo sapiens_hsa046620.10313916
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09230562
149HIF-1 signaling pathway_Homo sapiens_hsa040660.08819715
150Wnt signaling pathway_Homo sapiens_hsa043100.08769636
151N-Glycan biosynthesis_Homo sapiens_hsa005100.04213756
152Viral carcinogenesis_Homo sapiens_hsa052030.03740952
153Glutamatergic synapse_Homo sapiens_hsa047240.03123864

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