TMEM248

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.19665868
2COPI coating of Golgi vesicle (GO:0048205)9.19665868
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.52137505
4COPII vesicle coating (GO:0048208)6.05127401
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.89809142
6positive regulation of nuclease activity (GO:0032075)5.73149120
7protein retention in ER lumen (GO:0006621)5.67333643
8regulation of nuclease activity (GO:0032069)5.28733783
9protein maturation by protein folding (GO:0022417)5.13160388
10endoplasmic reticulum unfolded protein response (GO:0030968)5.11460385
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.01365265
12cellular response to unfolded protein (GO:0034620)4.97234005
13folic acid-containing compound biosynthetic process (GO:0009396)4.87417021
14ER-nucleus signaling pathway (GO:0006984)4.78466019
15cellular response to topologically incorrect protein (GO:0035967)4.76491422
16sequestering of metal ion (GO:0051238)4.64088024
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.56594452
18signal peptide processing (GO:0006465)4.37270723
194-hydroxyproline metabolic process (GO:0019471)4.35779517
20exocrine pancreas development (GO:0031017)4.30046527
21response to endoplasmic reticulum stress (GO:0034976)4.12663044
22vesicle coating (GO:0006901)4.03528836
23protein localization to endosome (GO:0036010)3.99625917
24response to unfolded protein (GO:0006986)3.93655999
25response to topologically incorrect protein (GO:0035966)3.82470179
26peptidyl-asparagine modification (GO:0018196)3.76183683
27protein N-linked glycosylation via asparagine (GO:0018279)3.76065260
28UDP-N-acetylglucosamine metabolic process (GO:0006047)3.72764287
29tetrahydrofolate metabolic process (GO:0046653)3.71045164
30endocrine pancreas development (GO:0031018)3.65005276
31L-alpha-amino acid transmembrane transport (GO:1902475)3.63353404
32intestinal cholesterol absorption (GO:0030299)3.54830596
33ER overload response (GO:0006983)3.54238421
34skin morphogenesis (GO:0043589)3.51847435
35valine metabolic process (GO:0006573)3.45947817
36protein N-linked glycosylation (GO:0006487)3.38617617
37regulation of early endosome to late endosome transport (GO:2000641)3.32248918
38peptide hormone processing (GO:0016486)3.29651330
39sulfur amino acid catabolic process (GO:0000098)3.28523083
40regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.28050867
41regulation of extracellular matrix disassembly (GO:0010715)3.26988434
42hypotonic response (GO:0006971)3.22560611
43regulation of hexokinase activity (GO:1903299)3.19590636
44regulation of glucokinase activity (GO:0033131)3.19590636
45barbed-end actin filament capping (GO:0051016)3.18249494
46pteridine-containing compound biosynthetic process (GO:0042559)3.16484960
47cysteine metabolic process (GO:0006534)3.12731902
48positive regulation of extracellular matrix organization (GO:1903055)3.11975396
49desmosome organization (GO:0002934)3.10567769
50cell adhesion mediated by integrin (GO:0033627)3.10007017
51stress fiber assembly (GO:0043149)3.08863943
52intestinal epithelial cell development (GO:0060576)3.07510046
53one-carbon metabolic process (GO:0006730)3.06212156
54negative regulation of erythrocyte differentiation (GO:0045647)3.05580118
55negative regulation of anoikis (GO:2000811)3.03484364
56type B pancreatic cell development (GO:0003323)3.02514926
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02210802
58L-phenylalanine catabolic process (GO:0006559)3.02210802
59surfactant homeostasis (GO:0043129)2.95980147
60peptide catabolic process (GO:0043171)2.95963900
61ER to Golgi vesicle-mediated transport (GO:0006888)2.95952582
62Golgi organization (GO:0007030)2.95610798
63peptidyl-glutamic acid carboxylation (GO:0017187)2.94653256
64protein carboxylation (GO:0018214)2.94653256
65negative regulation of protein localization to plasma membrane (GO:1903077)2.93781520
66embryonic process involved in female pregnancy (GO:0060136)2.91380482
67L-phenylalanine metabolic process (GO:0006558)2.88526007
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88526007
69cell-substrate junction assembly (GO:0007044)2.84915503
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83794409
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83794409
72proline biosynthetic process (GO:0006561)2.82636196
73negative regulation of fatty acid transport (GO:2000192)2.81555971
74folic acid-containing compound metabolic process (GO:0006760)2.80999992
75regulation of cholesterol homeostasis (GO:2000188)2.80077646
76cell redox homeostasis (GO:0045454)2.78468339
77positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78044820
78basement membrane organization (GO:0071711)2.77620875
79protein autoprocessing (GO:0016540)2.75217763
80response to laminar fluid shear stress (GO:0034616)2.73814169
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.73566358
82disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.73566358
83homocysteine metabolic process (GO:0050667)2.72893151
84transcytosis (GO:0045056)2.72470170
85regulation of anoikis (GO:2000209)2.71382800
86hormone catabolic process (GO:0042447)2.71270295
87positive regulation of receptor recycling (GO:0001921)2.71035719
88intestinal absorption (GO:0050892)2.71020655
89endodermal cell differentiation (GO:0035987)2.68750979
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.66355391
91glandular epithelial cell development (GO:0002068)2.66074012
92IMP biosynthetic process (GO:0006188)2.65446253
93negative regulation of glycoprotein biosynthetic process (GO:0010561)2.64867786
94lysine metabolic process (GO:0006553)2.64091093
95lysine catabolic process (GO:0006554)2.64091093
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.63533779
97regulation of translational fidelity (GO:0006450)2.63415775
98glandular epithelial cell differentiation (GO:0002067)2.62714413
99columnar/cuboidal epithelial cell development (GO:0002066)2.61997980
100cellular zinc ion homeostasis (GO:0006882)2.61555128
101epithelial cell-cell adhesion (GO:0090136)2.61430411
102chaperone mediated protein folding requiring cofactor (GO:0051085)2.60936931
103glycine metabolic process (GO:0006544)2.59839043
104regulation of plasminogen activation (GO:0010755)2.59817914
105pinocytosis (GO:0006907)2.58824508
106cell migration involved in heart development (GO:0060973)2.58496151
107protein hydroxylation (GO:0018126)2.57838548
108nuclear pore complex assembly (GO:0051292)2.57080877
109focal adhesion assembly (GO:0048041)2.56986225
110cell-substrate adherens junction assembly (GO:0007045)2.56986225
111negative regulation of fibrinolysis (GO:0051918)2.56059223
112regulation of extracellular matrix organization (GO:1903053)2.56039511
113maternal placenta development (GO:0001893)2.55747668
114tricarboxylic acid metabolic process (GO:0072350)2.55528810
115mannose metabolic process (GO:0006013)2.55212994
116adherens junction assembly (GO:0034333)2.54472857
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.53883557
118hemidesmosome assembly (GO:0031581)2.52361128
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51102056
120response to thyroid hormone (GO:0097066)2.50779884
121regulation of type B pancreatic cell apoptotic process (GO:2000674)2.49415648
122cellular modified amino acid catabolic process (GO:0042219)2.48647716
123adhesion of symbiont to host (GO:0044406)2.48200514
124cortical actin cytoskeleton organization (GO:0030866)2.47635715
125positive regulation of histone deacetylation (GO:0031065)2.45755689
126nuclear pore organization (GO:0006999)2.44149454
127maintenance of protein localization in organelle (GO:0072595)2.43545745
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43484758
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43460125
130macroautophagy (GO:0016236)2.42940631
131positive regulation of osteoblast proliferation (GO:0033690)2.41886968
132adhesion of symbiont to host cell (GO:0044650)2.40325153
133virion attachment to host cell (GO:0019062)2.40325153
134collagen fibril organization (GO:0030199)2.40222964
135pteridine-containing compound metabolic process (GO:0042558)2.38236813
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37345397
137hyaluronan catabolic process (GO:0030214)2.36948280
138ethanol oxidation (GO:0006069)2.36534943
139vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36122094
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.35814315
141regulation of fibrinolysis (GO:0051917)2.35399460
142regulation of glucocorticoid metabolic process (GO:0031943)2.34817337
143antigen processing and presentation of endogenous antigen (GO:0019883)2.34620400
144folic acid metabolic process (GO:0046655)2.34477125
145negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.34409759
146apoptotic cell clearance (GO:0043277)2.34345192
147chondrocyte development (GO:0002063)2.32954120
148cellular response to thyroid hormone stimulus (GO:0097067)2.32864964
149activation of Rac GTPase activity (GO:0032863)2.32630375
150cellular response to glucose starvation (GO:0042149)2.31404647
151alpha-linolenic acid metabolic process (GO:0036109)2.31387537
152regulation of nucleobase-containing compound transport (GO:0032239)2.30435665
153chondrocyte proliferation (GO:0035988)2.29126335
154aromatic amino acid family catabolic process (GO:0009074)2.29117638
155negative regulation of cell size (GO:0045792)2.28658548
156branching involved in mammary gland duct morphogenesis (GO:0060444)2.27989088
157complement activation, alternative pathway (GO:0006957)2.27920160
158high-density lipoprotein particle remodeling (GO:0034375)2.27848572
159oxaloacetate metabolic process (GO:0006107)2.27745488
160peptidyl-proline hydroxylation (GO:0019511)2.26504248
161membrane protein ectodomain proteolysis (GO:0006509)2.26068342
162membrane raft organization (GO:0031579)2.25557314
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24349571
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.23453042
165vascular endothelial growth factor signaling pathway (GO:0038084)2.22213571
166collagen metabolic process (GO:0032963)2.19120089
167cortical cytoskeleton organization (GO:0030865)2.17752968
168multicellular organismal macromolecule metabolic process (GO:0044259)2.16858632
169iron ion import (GO:0097286)2.16665100
170cellular response to epidermal growth factor stimulus (GO:0071364)2.15952413
171regulation of transforming growth factor beta1 production (GO:0032908)2.14371049
172positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.13380965
173fibril organization (GO:0097435)2.12190165
174regulation of protein localization to plasma membrane (GO:1903076)2.10474655
175viral entry into host cell (GO:0046718)2.10039207
176regulation of apoptotic cell clearance (GO:2000425)2.09651598
177cell volume homeostasis (GO:0006884)2.09206846
178extracellular matrix disassembly (GO:0022617)2.08974534
179modulation by symbiont of host cellular process (GO:0044068)2.08541739
180endocytic recycling (GO:0032456)2.07716377
181negative regulation of chondrocyte differentiation (GO:0032331)2.07656920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.44380573
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31021633
3E2F7_22180533_ChIP-Seq_HELA_Human4.00039060
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.88328879
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.19652965
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.09079041
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05202128
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.73094521
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65501151
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.52510013
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40283266
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32282060
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.31852483
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30629600
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.28594661
16GATA1_22025678_ChIP-Seq_K562_Human2.28258894
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21158255
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20518479
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.15009588
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.08495738
21MYC_22102868_ChIP-Seq_BL_Human2.08094978
22ZNF263_19887448_ChIP-Seq_K562_Human2.02698553
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01536529
24CLOCK_20551151_ChIP-Seq_293T_Human1.99377320
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93839819
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89634506
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.89345127
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89224303
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81893174
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80126768
31RACK7_27058665_Chip-Seq_MCF-7_Human1.79592630
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75337051
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74863509
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72509075
35LXR_22292898_ChIP-Seq_THP-1_Human1.71917249
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71646998
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71253573
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70355018
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69307472
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68164651
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67607980
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64890149
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.62225247
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.61294182
45TFEB_21752829_ChIP-Seq_HELA_Human1.57918866
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56630435
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55476309
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51868388
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50361762
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50361762
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49592399
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.48552372
53KDM5A_27292631_Chip-Seq_BREAST_Human1.46555195
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45672655
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45604602
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45109624
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42960034
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42954920
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42503490
60KDM2B_26808549_Chip-Seq_K562_Human1.42286170
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41809357
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41444420
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.40930344
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39676212
65KDM2B_26808549_Chip-Seq_DND41_Human1.38203774
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35871424
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35127326
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34247747
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33869651
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33576382
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33140488
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.33055340
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33048616
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.32709057
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.32709057
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31926210
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31796427
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31246097
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30740686
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28843655
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28381243
82CHD1_26751641_Chip-Seq_LNCaP_Human1.27835028
83AR_21909140_ChIP-Seq_LNCAP_Human1.27666535
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26579184
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25727891
86ATF3_27146783_Chip-Seq_COLON_Human1.23797812
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23457363
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23210267
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21715014
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.21419785
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.20355929
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.19948843
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19602423
94GABP_19822575_ChIP-Seq_HepG2_Human1.19328997
95GATA6_25053715_ChIP-Seq_YYC3_Human1.19219563
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18142731
97VDR_24763502_ChIP-Seq_THP-1_Human1.17199417
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17122848
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17103176
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16929609
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.16531488
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15821097
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.15533709
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.15421010
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15295285
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.14932650
107DCP1A_22483619_ChIP-Seq_HELA_Human1.14508611
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14434544
109GATA1_19941826_ChIP-Seq_K562_Human1.14371966
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14310483
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13311912
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13193740
113SOX2_20726797_ChIP-Seq_SW620_Human1.11815720
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11765018
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11171912
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11026322
117MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11004242
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10423548
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10411888
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10041340
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09117671
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08541450
123SPI1_23127762_ChIP-Seq_K562_Human1.08413716
124VDR_21846776_ChIP-Seq_THP-1_Human1.08261095
125EST1_17652178_ChIP-ChIP_JURKAT_Human1.08190977
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07617661
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06604344
128TCF7_22412390_ChIP-Seq_EML_Mouse1.06584936
129XRN2_22483619_ChIP-Seq_HELA_Human1.06094255
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06039858
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05927284
132E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05704571
133ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05304668
134ETS1_20019798_ChIP-Seq_JURKAT_Human1.04914449
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04759992
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04353737
137RUNX1_27514584_Chip-Seq_MCF-7_Human1.03322099
138MYB_26560356_Chip-Seq_TH1_Human1.00883711
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99098094
140SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98210838
141MYB_26560356_Chip-Seq_TH2_Human0.97287665
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.97286406
143BRD4_25478319_ChIP-Seq_HGPS_Human0.96954502
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96600896
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95876123
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95624572
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95595958
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95093077
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94985918
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94948052
151VDR_23849224_ChIP-Seq_CD4+_Human0.94524578
152HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94521361
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94500222
154FOXP3_21729870_ChIP-Seq_TREG_Human0.94209974
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93851313
156GATA4_25053715_ChIP-Seq_YYC3_Human0.92347196
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91961237
158NCOR1_26117541_ChIP-Seq_K562_Human0.91128185
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90551548
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89457982
161UTX_26944678_Chip-Seq_JUKART_Human0.89249569
162FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88558844
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.87828020
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87431407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.48348725
2MP0002139_abnormal_hepatobiliary_system3.43519941
3MP0005365_abnormal_bile_salt3.21758903
4MP0004264_abnormal_extraembryonic_tissu2.59754007
5MP0005220_abnormal_exocrine_pancreas2.53951429
6MP0005083_abnormal_biliary_tract2.52132026
7MP0002693_abnormal_pancreas_physiology2.46463451
8MP0005085_abnormal_gallbladder_physiolo2.45611515
9MP0005275_abnormal_skin_tensile2.38815537
10MP0003705_abnormal_hypodermis_morpholog2.33023385
11MP0001944_abnormal_pancreas_morphology2.25771187
12MP0001958_emphysema2.25483125
13MP0003091_abnormal_cell_migration2.22227633
14MP0003300_gastrointestinal_ulcer2.19101693
15MP0003279_aneurysm2.09156705
16MP0001666_abnormal_nutrient_absorption2.08673360
17MP0005360_urolithiasis2.07159230
18MP0006054_spinal_hemorrhage2.02023190
19MP0005409_darkened_coat_color1.98370873
20MP0005076_abnormal_cell_differentiation1.97936667
21MP0003806_abnormal_nucleotide_metabolis1.93561924
22MP0004043_abnormal_pH_regulation1.93507479
23MP0003283_abnormal_digestive_organ1.92153540
24MP0005503_abnormal_tendon_morphology1.89726457
25MP0010352_gastrointestinal_tract_polyps1.87693952
26MP0003183_abnormal_peptide_metabolism1.82695810
27MP0003252_abnormal_bile_duct1.80450504
28MP0008875_abnormal_xenobiotic_pharmacok1.77310726
29MP0010368_abnormal_lymphatic_system1.70391481
30MP0003195_calcinosis1.70305619
31MP0003693_abnormal_embryo_hatching1.65186837
32MP0010234_abnormal_vibrissa_follicle1.62284168
33MP0009840_abnormal_foam_cell1.61377054
34MP0002138_abnormal_hepatobiliary_system1.56266089
35MP0003566_abnormal_cell_adhesion1.55752474
36MP0001849_ear_inflammation1.55643773
37MP0003453_abnormal_keratinocyte_physiol1.49304583
38MP0009643_abnormal_urine_homeostasis1.48976419
39MP0002078_abnormal_glucose_homeostasis1.46862997
40MP0000609_abnormal_liver_physiology1.46813092
41MP0003868_abnormal_feces_composition1.46419909
42MP0005058_abnormal_lysosome_morphology1.45541381
43MP0005408_hypopigmentation1.43120915
44MP0003303_peritoneal_inflammation1.42769498
45MP0010329_abnormal_lipoprotein_level1.37200402
46MP0005623_abnormal_meninges_morphology1.36105080
47MP0000767_abnormal_smooth_muscle1.34770980
48MP0002396_abnormal_hematopoietic_system1.34518048
49MP0004957_abnormal_blastocyst_morpholog1.30502127
50MP0005379_endocrine/exocrine_gland_phen1.23577092
51MP0003186_abnormal_redox_activity1.22383350
52MP0008438_abnormal_cutaneous_collagen1.21795684
53MP0001915_intracranial_hemorrhage1.20836718
54MP0008961_abnormal_basal_metabolism1.19232161
55MP0003436_decreased_susceptibility_to1.18118205
56MP0001348_abnormal_lacrimal_gland1.17228022
57MP0005451_abnormal_body_composition1.16507306
58MP0002909_abnormal_adrenal_gland1.15615434
59MP0008260_abnormal_autophagy1.14500916
60MP0010386_abnormal_urinary_bladder1.14435376
61MP0003950_abnormal_plasma_membrane1.13643643
62MP0008004_abnormal_stomach_pH1.13448449
63MP0004858_abnormal_nervous_system1.09971363
64MP0005332_abnormal_amino_acid1.09383866
65MP0000598_abnormal_liver_morphology1.08300396
66MP0002998_abnormal_bone_remodeling1.08002775
67MP0002118_abnormal_lipid_homeostasis1.07635859
68MP0009780_abnormal_chondrocyte_physiolo1.05839038
69MP0005319_abnormal_enzyme/_coenzyme1.05528833
70MP0009384_cardiac_valve_regurgitation1.05383415
71MP0000678_abnormal_parathyroid_gland1.05379985
72MP0004808_abnormal_hematopoietic_stem1.04629322
73MP0001851_eye_inflammation1.04627453
74MP0001756_abnormal_urination1.03640527
75MP0000613_abnormal_salivary_gland1.02507704
76MP0005464_abnormal_platelet_physiology1.02193238
77MP0003329_amyloid_beta_deposits1.00454399
78MP0010307_abnormal_tumor_latency1.00039161
79MP0003172_abnormal_lysosome_physiology0.99255152
80MP0009672_abnormal_birth_weight0.99216976
81MP0005164_abnormal_response_to0.96937880
82MP0002796_impaired_skin_barrier0.96784872
83MP0000858_altered_metastatic_potential0.95413536
84MP0003448_altered_tumor_morphology0.95035315
85MP0004185_abnormal_adipocyte_glucose0.93650438
86MP0005165_increased_susceptibility_to0.92447898
87MP0004782_abnormal_surfactant_physiolog0.92435505
88MP0003191_abnormal_cellular_cholesterol0.91805035
89MP0004233_abnormal_muscle_weight0.91558791
90MP0001879_abnormal_lymphatic_vessel0.89938048
91MP0005636_abnormal_mineral_homeostasis0.88410783
92MP0002166_altered_tumor_susceptibility0.88350519
93MP0002896_abnormal_bone_mineralization0.87439003
94MP0003763_abnormal_thymus_physiology0.86939656
95MP0005023_abnormal_wound_healing0.86228607
96MP0002837_dystrophic_cardiac_calcinosis0.85969620
97MP0001730_embryonic_growth_arrest0.84651001
98MP0005508_abnormal_skeleton_morphology0.83997090
99MP0000604_amyloidosis0.83914025
100MP0001661_extended_life_span0.82724635
101MP0003959_abnormal_lean_body0.81442125
102MP0002009_preneoplasia0.81351014
103MP0010155_abnormal_intestine_physiology0.81295312
104MP0003984_embryonic_growth_retardation0.80578395
105MP0004947_skin_inflammation0.80471583
106MP0002086_abnormal_extraembryonic_tissu0.80264868
107MP0001765_abnormal_ion_homeostasis0.80102828
108MP0002088_abnormal_embryonic_growth/wei0.80036922
109MP0001216_abnormal_epidermal_layer0.79891836
110MP0000733_abnormal_muscle_development0.79692309
111MP0005375_adipose_tissue_phenotype0.79389782
112MP0000534_abnormal_ureter_morphology0.79350912
113MP0002089_abnormal_postnatal_growth/wei0.79053093
114MP0003828_pulmonary_edema0.79025378
115MP0004197_abnormal_fetal_growth/weight/0.78788418
116MP0006138_congestive_heart_failure0.77346630
117MP0005257_abnormal_intraocular_pressure0.77127257
118MP0000462_abnormal_digestive_system0.76876015
119MP0005310_abnormal_salivary_gland0.76839472
120MP0003795_abnormal_bone_structure0.76145330
121MP0001764_abnormal_homeostasis0.76132745
122MP0001542_abnormal_bone_strength0.76034270
123MP0000013_abnormal_adipose_tissue0.75531101
124MP0001614_abnormal_blood_vessel0.74984675
125MP0001845_abnormal_inflammatory_respons0.74966214
126MP0000762_abnormal_tongue_morphology0.73653499
127MP0002295_abnormal_pulmonary_circulatio0.73338062
128MP0008057_abnormal_DNA_replication0.72874070
129MP0005666_abnormal_adipose_tissue0.72733558
130MP0005390_skeleton_phenotype0.71346088
131MP0005380_embryogenesis_phenotype0.70763504
132MP0001672_abnormal_embryogenesis/_devel0.70763504
133MP0000681_abnormal_thyroid_gland0.70028503
134MP0003890_abnormal_embryonic-extraembry0.69998582
135MP0003075_altered_response_to0.69677970
136MP0003045_fibrosis0.69362603
137MP0002060_abnormal_skin_morphology0.68553215
138MP0002928_abnormal_bile_duct0.68522824
139MP0009278_abnormal_bone_marrow0.68085802
140MP0009642_abnormal_blood_homeostasis0.67885924
141MP0002080_prenatal_lethality0.67552335
142MP0008469_abnormal_protein_level0.67349078
143MP0000350_abnormal_cell_proliferation0.66637912
144MP0003953_abnormal_hormone_level0.66589843
145MP0000627_abnormal_mammary_gland0.65622398
146MP0005388_respiratory_system_phenotype0.65519152
147MP0002133_abnormal_respiratory_system0.65519152
148MP0000249_abnormal_blood_vessel0.64820902
149MP0000465_gastrointestinal_hemorrhage0.64774788
150MP0002128_abnormal_blood_circulation0.64706566
151MP0001697_abnormal_embryo_size0.64347703
152MP0005621_abnormal_cell_physiology0.64180140
153MP0001533_abnormal_skeleton_physiology0.63450206
154MP0003656_abnormal_erythrocyte_physiolo0.63413107
155MP0009703_decreased_birth_body0.63348821
156MP0002269_muscular_atrophy0.62896432
157MP0000003_abnormal_adipose_tissue0.62894918
158MP0001243_abnormal_dermal_layer0.62830134
159MP0001881_abnormal_mammary_gland0.61327114
160MP0000358_abnormal_cell_content/0.61318913
161MP0003077_abnormal_cell_cycle0.60401378
162MP0004272_abnormal_basement_membrane0.59875004
163MP0003119_abnormal_digestive_system0.58532601

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.49860613
2Hypoglycemic seizures (HP:0002173)5.32863289
3Hypoglycemic coma (HP:0001325)5.30588662
4Protrusio acetabuli (HP:0003179)4.69605574
5Premature rupture of membranes (HP:0001788)4.43569604
6Abnormality of the intrinsic pathway (HP:0010989)4.42036298
7Symptomatic seizures (HP:0011145)4.16211083
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90724713
9Abnormality of the pancreatic islet cells (HP:0006476)3.78564348
10Abnormality of endocrine pancreas physiology (HP:0012093)3.78564348
11Abnormality of the common coagulation pathway (HP:0010990)3.68947962
12Hyperglycemia (HP:0003074)3.64989616
13Vascular tortuosity (HP:0004948)3.58943011
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58856784
15Intrahepatic cholestasis (HP:0001406)3.51486792
16Late onset (HP:0003584)3.49227996
17Arterial tortuosity (HP:0005116)3.44736524
18Mucopolysacchariduria (HP:0008155)3.43886426
19Urinary glycosaminoglycan excretion (HP:0003541)3.43886426
20Vertebral compression fractures (HP:0002953)3.39754041
21Ketoacidosis (HP:0001993)3.34157742
22Aortic dissection (HP:0002647)3.15334341
23Pancreatic islet-cell hyperplasia (HP:0004510)3.15230904
24Aortic aneurysm (HP:0004942)3.05363747
25Dysostosis multiplex (HP:0000943)3.01470625
26Osteolytic defects of the hand bones (HP:0009699)2.99701029
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.99701029
28Insulin-resistant diabetes mellitus (HP:0000831)2.98905064
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96867725
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96867725
31Abnormality of polysaccharide metabolism (HP:0011012)2.96867725
32Deep venous thrombosis (HP:0002625)2.95646357
33Flat acetabular roof (HP:0003180)2.84567526
34Ketosis (HP:0001946)2.82339759
35Generalized aminoaciduria (HP:0002909)2.79814441
36Conjugated hyperbilirubinemia (HP:0002908)2.76599847
37Xanthomatosis (HP:0000991)2.75775813
38Wormian bones (HP:0002645)2.74662373
39Dilatation of the ascending aorta (HP:0005111)2.69753026
40Fat malabsorption (HP:0002630)2.60528688
41Bladder diverticulum (HP:0000015)2.57016385
42Insulin resistance (HP:0000855)2.54334836
43Atrophic scars (HP:0001075)2.53736214
44Gastrointestinal infarctions (HP:0005244)2.48460125
45Prolonged partial thromboplastin time (HP:0003645)2.46050775
46Gout (HP:0001997)2.45059818
47Fragile skin (HP:0001030)2.43789200
48Abnormality of the anterior horn cell (HP:0006802)2.43535114
49Degeneration of anterior horn cells (HP:0002398)2.43535114
50Skin nodule (HP:0200036)2.43225980
51Ankle contracture (HP:0006466)2.42082491
52Mitral valve prolapse (HP:0001634)2.38985720
53Blue sclerae (HP:0000592)2.36531142
54Hyperacusis (HP:0010780)2.36201846
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35087695
56Peritonitis (HP:0002586)2.34824353
57Biconcave vertebral bodies (HP:0004586)2.34505575
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.31658743
59Hypobetalipoproteinemia (HP:0003563)2.31597193
60Back pain (HP:0003418)2.31586114
61Acute hepatic failure (HP:0006554)2.29814933
62Spondylolisthesis (HP:0003302)2.29730171
63Short nail (HP:0001799)2.20289030
64Thrombocytosis (HP:0001894)2.19021098
65Cervical subluxation (HP:0003308)2.18685057
66Abnormality of purine metabolism (HP:0004352)2.18502776
67Broad face (HP:0000283)2.17774104
68Ankyloglossia (HP:0010296)2.17182630
69Hand muscle atrophy (HP:0009130)2.16509894
70Mitral stenosis (HP:0001718)2.16336332
71Pancreatitis (HP:0001733)2.15850692
72Thin bony cortex (HP:0002753)2.14186141
73Abnormality of the acetabulum (HP:0003170)2.14086703
74Abnormal biliary tract morphology (HP:0012440)2.12892255
75Vacuolated lymphocytes (HP:0001922)2.11393740
76Neonatal short-limb short stature (HP:0008921)2.10902812
77Myocardial infarction (HP:0001658)2.09244010
78Systemic lupus erythematosus (HP:0002725)2.08489062
79Shallow orbits (HP:0000586)2.07680117
80Limb hypertonia (HP:0002509)2.07181976
81Abnormality of carpal bone ossification (HP:0006257)2.06888822
82Asymmetry of the thorax (HP:0001555)2.06592852
83Abnormality of nucleobase metabolism (HP:0010932)2.05974783
84Mitral regurgitation (HP:0001653)2.04051096
85Prominent metopic ridge (HP:0005487)2.03852151
86Spontaneous hematomas (HP:0007420)2.03057672
87Broad metatarsal (HP:0001783)2.02791461
88Thoracolumbar scoliosis (HP:0002944)2.02476564
89Hyperextensible skin (HP:0000974)2.01848560
90Joint laxity (HP:0001388)2.00349342
91Abnormality of oral frenula (HP:0000190)1.99689671
92Soft skin (HP:0000977)1.99222585
93Abnormal pancreas size (HP:0012094)1.98863993
94Elevated alkaline phosphatase (HP:0003155)1.98081249
95Spinal rigidity (HP:0003306)1.97631464
96Complement deficiency (HP:0004431)1.96904761
97Disproportionate tall stature (HP:0001519)1.96567974
98Interstitial pulmonary disease (HP:0006530)1.96440838
99Spinal cord lesions (HP:0100561)1.96288470
100Syringomyelia (HP:0003396)1.96288470
101Abnormal ossification of hand bones (HP:0005921)1.96240161
102Abnormal enzyme/coenzyme activity (HP:0012379)1.94262246
103Large for gestational age (HP:0001520)1.92987830
104Abnormality of alkaline phosphatase activity (HP:0004379)1.91991054
105Arterial thrombosis (HP:0004420)1.90702140
106Genu recurvatum (HP:0002816)1.89961148
107Abdominal distention (HP:0003270)1.89925581
108Insomnia (HP:0100785)1.89523633
109Hyperbilirubinemia (HP:0002904)1.88994649
110Severe short stature (HP:0003510)1.87981702
111Steatorrhea (HP:0002570)1.87250206
112Polycythemia (HP:0001901)1.85916446
113Abnormality of transition element cation homeostasis (HP:0011030)1.85609408
114Abnormality of dentin (HP:0010299)1.85336355
115Exocrine pancreatic insufficiency (HP:0001738)1.84644501
116Eczematoid dermatitis (HP:0000976)1.83118366
117Vertebral arch anomaly (HP:0008438)1.81612887
118Aneurysm (HP:0002617)1.81125756
119Abnormality of pyrimidine metabolism (HP:0004353)1.80918799
120Ulnar bowing (HP:0003031)1.80069299
121Increased connective tissue (HP:0009025)1.79927690
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78121588
123Hypolipoproteinemia (HP:0010981)1.77610178
124Esophageal varix (HP:0002040)1.76476156
125Abnormal cartilage morphology (HP:0002763)1.76366696
126Hyperglycinemia (HP:0002154)1.75138928
127Increased variability in muscle fiber diameter (HP:0003557)1.74927277
128Cerebral inclusion bodies (HP:0100314)1.74869145
129Abnormality of the distal phalanges of the toes (HP:0010182)1.74739788
130Cerebral aneurysm (HP:0004944)1.72829500
131Neurofibrillary tangles (HP:0002185)1.72484443
132Aortic regurgitation (HP:0001659)1.72476347
133Osteomalacia (HP:0002749)1.71608071
134Beaking of vertebral bodies (HP:0004568)1.71325915
135Thrombophlebitis (HP:0004418)1.71118438
136Progressive neurologic deterioration (HP:0002344)1.70452491
137Persistence of primary teeth (HP:0006335)1.69773487
138Abnormality of T cell physiology (HP:0011840)1.69660774
139Multiple enchondromatosis (HP:0005701)1.69381489
140Elevated erythrocyte sedimentation rate (HP:0003565)1.68691217
141Mildly elevated creatine phosphokinase (HP:0008180)1.68392047
142Hyperparathyroidism (HP:0000843)1.68131492
143Upper limb amyotrophy (HP:0009129)1.67817535
144Distal upper limb amyotrophy (HP:0007149)1.67817535
145Abnormality of the metopic suture (HP:0005556)1.67810664
146Cellulitis (HP:0100658)1.66942203
147Abnormality of complement system (HP:0005339)1.66744157
148Hyperlipoproteinemia (HP:0010980)1.66424277
149Abnormal foot bone ossification (HP:0010675)1.66398544
150Biliary tract neoplasm (HP:0100574)1.66254868
151Coxa vara (HP:0002812)1.66188275
152Overgrowth (HP:0001548)1.66108250
153Bowel diverticulosis (HP:0005222)1.65908033
154Type I diabetes mellitus (HP:0100651)1.65404649
155Joint hemorrhage (HP:0005261)1.64762164
156Abnormality of subcutaneous fat tissue (HP:0001001)1.64226898
157Asymmetric septal hypertrophy (HP:0001670)1.64098176
158Elbow flexion contracture (HP:0002987)1.63185791
159Bone pain (HP:0002653)1.63037536
160Malnutrition (HP:0004395)1.62463498
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.62313185
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.61968366
163Abnormality of fatty-acid metabolism (HP:0004359)1.61893003
164Abnormal platelet function (HP:0011869)1.61799187
165Impaired platelet aggregation (HP:0003540)1.61799187
166Menorrhagia (HP:0000132)1.61735192
167Glomerulonephritis (HP:0000099)1.60619948
168Chronic bronchitis (HP:0004469)1.60175809
169J-shaped sella turcica (HP:0002680)1.59955814
170Recurrent gram-negative bacterial infections (HP:0005420)1.59909282
171Abnormal hand bone ossification (HP:0010660)1.59835267
172Absent frontal sinuses (HP:0002688)1.59644914
173Abnormality of skull ossification (HP:0002703)1.59297137
174Venous abnormality (HP:0002624)1.59254692
175Abnormal delivery (HP:0001787)1.59015750
176Abnormality of the thoracic spine (HP:0100711)1.58869201
177Advanced eruption of teeth (HP:0006288)1.58724758
178Natal tooth (HP:0000695)1.57647974
179Protuberant abdomen (HP:0001538)1.57530471
180Hyperglycinuria (HP:0003108)1.57401430
181Abnormality of glutamine family amino acid metabolism (HP:0010902)1.56891671
182Cupped ribs (HP:0000887)1.56674025
183Hemorrhage of the eye (HP:0011885)1.55880695
184Spinal cord compression (HP:0002176)1.55789795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.01537964
2TAOK34.76520109
3PASK3.19395926
4INSRR2.90192720
5PRPF4B2.84684327
6FLT32.58954476
7TRIB32.53845487
8IRAK32.50261547
9FRK2.47962529
10BCKDK2.09851594
11SMG12.06176740
12PKN22.02753001
13EEF2K1.96362548
14ICK1.96199325
15SCYL21.92305910
16LATS21.84072113
17MST1R1.83321031
18SIK11.77961658
19CDK121.77143497
20STK101.76125111
21MAP3K101.74557057
22BRSK21.73931173
23EIF2AK31.64708225
24PTK61.59041381
25LATS11.57110825
26KSR21.52694447
27ZAP701.50670911
28MAP3K131.48357852
29MAP2K31.40906229
30MAP3K21.40317915
31JAK31.38182541
32HIPK21.37662745
33LMTK21.35771745
34PRKD31.32159698
35MAP3K31.28697546
36EPHA21.28073343
37PDGFRA1.26851708
38AKT31.26697538
39IRAK41.23412358
40MAP3K11.20951701
41DDR21.17630863
42RPS6KA41.14856391
43LRRK21.13868816
44ARAF1.10682927
45PTK21.10643191
46TESK11.08608522
47NEK91.05786885
48MYLK0.98668968
49STK240.97725738
50RPS6KB20.96164742
51CDC42BPA0.95968898
52MET0.94924944
53PRKD20.94459737
54FGFR40.93076499
55MOS0.93049507
56STK380.90266323
57JAK20.90242061
58MTOR0.89141774
59MAP3K80.88730679
60RET0.88185379
61MAPKAPK30.86460966
62ACVR1B0.86341951
63PDK40.85953815
64PDK30.85953815
65PRKG20.84395005
66TRPM70.81066619
67IRAK10.80097859
68PDPK10.78540723
69TBK10.77344509
70DMPK0.75574841
71STK30.72461808
72BTK0.71777831
73MAP2K20.70757041
74MAPK110.70602320
75BMX0.70205708
76NTRK10.70132248
77MARK20.70120098
78CHUK0.69936411
79MAP3K90.69661525
80RPS6KA20.69064991
81YES10.69016847
82MAPK150.68839620
83RIPK10.68728477
84EPHB20.67667304
85NEK60.67577107
86PIM20.66979056
87CDK60.66759790
88CDK90.65374308
89EPHA30.63327070
90BMPR20.62733163
91KSR10.62382484
92PAK40.60051119
93CDC70.59631909
94TYRO30.59253876
95EIF2AK10.58969590
96TAOK20.58509325
97ITK0.57408373
98TTN0.56809695
99TGFBR20.56446114
100MAP3K50.55808121
101SGK30.55370291
102RIPK40.54414472
103ROCK20.54040650
104MAP3K110.53416624
105WEE10.53334864
106CSK0.53215350
107RAF10.52511040
108MST40.52292728
109PIM10.52035466
110TEC0.51607127
111FGFR30.50500050
112MAP3K70.48813015
113NEK20.48570458
114WNK40.47819358
115MARK30.47776332
116CDK40.46840644
117MAP2K10.46224184
118JAK10.45924366
119PRKCI0.45660546
120RPS6KB10.44707835
121ILK0.44492842
122GSK3A0.42897768
123ERBB40.42808108
124ALK0.41601598
125MAP3K140.41259906
126MAP3K60.41158025
127PIK3CG0.40452956
128STK38L0.40302803
129BRAF0.40284018
130MAPKAPK20.40135026
131PDK10.39997469
132SIK30.39953176
133EPHB10.39762169
134CLK10.38870958
135NME20.38048689
136TYK20.37383426
137RPS6KC10.37170486
138RPS6KL10.37170486
139MELK0.36986768
140FGR0.36943630
141PAK20.35604526
142PDGFRB0.35442759
143CDK70.35380701
144PDK20.34504501
145TGFBR10.33441838
146RPS6KA60.32882477
147MAP4K10.32316457

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.59163098
2Protein export_Homo sapiens_hsa030604.58686974
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.93651931
4Selenocompound metabolism_Homo sapiens_hsa004502.87342439
5Sulfur metabolism_Homo sapiens_hsa009202.66552863
6One carbon pool by folate_Homo sapiens_hsa006702.60424275
7N-Glycan biosynthesis_Homo sapiens_hsa005101.89070746
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.76438004
9ECM-receptor interaction_Homo sapiens_hsa045121.72356211
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.71120797
11Tryptophan metabolism_Homo sapiens_hsa003801.69634692
12Focal adhesion_Homo sapiens_hsa045101.69523121
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61932721
14Pancreatic cancer_Homo sapiens_hsa052121.59446366
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57734530
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55243790
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.51779896
18Fatty acid degradation_Homo sapiens_hsa000711.51179956
19Non-small cell lung cancer_Homo sapiens_hsa052231.51007351
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50344318
21Renal cell carcinoma_Homo sapiens_hsa052111.44200218
22Proteoglycans in cancer_Homo sapiens_hsa052051.40328894
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38052547
24Fat digestion and absorption_Homo sapiens_hsa049751.36802228
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30805028
26Small cell lung cancer_Homo sapiens_hsa052221.30411100
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30332740
28Endometrial cancer_Homo sapiens_hsa052131.29729597
29Folate biosynthesis_Homo sapiens_hsa007901.29525528
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26852877
31Complement and coagulation cascades_Homo sapiens_hsa046101.25163336
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23866694
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23674062
34Other glycan degradation_Homo sapiens_hsa005111.23637561
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.23279242
36Sulfur relay system_Homo sapiens_hsa041221.21395454
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18824610
38B cell receptor signaling pathway_Homo sapiens_hsa046621.17780594
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.16988300
40Antigen processing and presentation_Homo sapiens_hsa046121.13894836
41Legionellosis_Homo sapiens_hsa051341.13530666
42Type I diabetes mellitus_Homo sapiens_hsa049401.12782590
43Insulin resistance_Homo sapiens_hsa049311.12348956
44VEGF signaling pathway_Homo sapiens_hsa043701.07134887
45Arginine biosynthesis_Homo sapiens_hsa002201.06515742
46Glioma_Homo sapiens_hsa052141.06497677
47Osteoclast differentiation_Homo sapiens_hsa043801.05888747
48Starch and sucrose metabolism_Homo sapiens_hsa005001.05773432
49Galactose metabolism_Homo sapiens_hsa000521.04781555
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04542273
51Lysosome_Homo sapiens_hsa041421.03613331
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02579433
53Thyroid cancer_Homo sapiens_hsa052161.00094959
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.99537443
55Nitrogen metabolism_Homo sapiens_hsa009100.99298973
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98675569
57Bladder cancer_Homo sapiens_hsa052190.97877270
58Phenylalanine metabolism_Homo sapiens_hsa003600.96358629
59Lysine degradation_Homo sapiens_hsa003100.96073804
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94888905
61MicroRNAs in cancer_Homo sapiens_hsa052060.94793905
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93795822
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93610180
64Inositol phosphate metabolism_Homo sapiens_hsa005620.91883834
65Notch signaling pathway_Homo sapiens_hsa043300.90703066
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.89162292
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89131127
68Histidine metabolism_Homo sapiens_hsa003400.88754963
69Hepatitis C_Homo sapiens_hsa051600.88395093
70ErbB signaling pathway_Homo sapiens_hsa040120.87246409
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86484486
72Hepatitis B_Homo sapiens_hsa051610.86245673
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85445890
74Malaria_Homo sapiens_hsa051440.83511686
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83272963
76Platelet activation_Homo sapiens_hsa046110.83071168
77Biosynthesis of amino acids_Homo sapiens_hsa012300.82360906
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.82119083
79Endocytosis_Homo sapiens_hsa041440.81597666
80Caffeine metabolism_Homo sapiens_hsa002320.81595455
81Pertussis_Homo sapiens_hsa051330.80662416
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.77879189
83TNF signaling pathway_Homo sapiens_hsa046680.77595825
84Colorectal cancer_Homo sapiens_hsa052100.77549158
85Tyrosine metabolism_Homo sapiens_hsa003500.77153509
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76338373
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74787528
88Carbon metabolism_Homo sapiens_hsa012000.74061818
89Type II diabetes mellitus_Homo sapiens_hsa049300.73154321
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72154623
91Choline metabolism in cancer_Homo sapiens_hsa052310.71808125
92Shigellosis_Homo sapiens_hsa051310.71086657
93Glucagon signaling pathway_Homo sapiens_hsa049220.70846312
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70482467
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70199395
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70137120
97RNA transport_Homo sapiens_hsa030130.69752691
98Pentose phosphate pathway_Homo sapiens_hsa000300.69704052
99Influenza A_Homo sapiens_hsa051640.69224880
100HIF-1 signaling pathway_Homo sapiens_hsa040660.67603939
101GnRH signaling pathway_Homo sapiens_hsa049120.66956202
102Sphingolipid metabolism_Homo sapiens_hsa006000.66110813
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66092447
104Peroxisome_Homo sapiens_hsa041460.65792478
105ABC transporters_Homo sapiens_hsa020100.64583283
106Propanoate metabolism_Homo sapiens_hsa006400.64570996
107Estrogen signaling pathway_Homo sapiens_hsa049150.64493681
108Prolactin signaling pathway_Homo sapiens_hsa049170.64225804
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63959226
110Pathways in cancer_Homo sapiens_hsa052000.63332695
111Renin-angiotensin system_Homo sapiens_hsa046140.62824097
112Phagosome_Homo sapiens_hsa041450.62096835
113Apoptosis_Homo sapiens_hsa042100.61389987
114Staphylococcus aureus infection_Homo sapiens_hsa051500.61388342
115Measles_Homo sapiens_hsa051620.60500600
116HTLV-I infection_Homo sapiens_hsa051660.59576743
117Chronic myeloid leukemia_Homo sapiens_hsa052200.59125392
118Salmonella infection_Homo sapiens_hsa051320.58998160
119Fructose and mannose metabolism_Homo sapiens_hsa000510.57462771
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.57459799
121Prostate cancer_Homo sapiens_hsa052150.57339038
122Rap1 signaling pathway_Homo sapiens_hsa040150.56877729
123Bile secretion_Homo sapiens_hsa049760.56838619
124Chemokine signaling pathway_Homo sapiens_hsa040620.56654146
125beta-Alanine metabolism_Homo sapiens_hsa004100.56543383
126Chemical carcinogenesis_Homo sapiens_hsa052040.56462795
127Fatty acid metabolism_Homo sapiens_hsa012120.55136392
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54435826
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54098437
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53766447
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53011749
132Tuberculosis_Homo sapiens_hsa051520.52841097
133FoxO signaling pathway_Homo sapiens_hsa040680.52362590
134Prion diseases_Homo sapiens_hsa050200.51024734
135Thyroid hormone synthesis_Homo sapiens_hsa049180.50069662
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48615789
137Pyruvate metabolism_Homo sapiens_hsa006200.47906881
138PPAR signaling pathway_Homo sapiens_hsa033200.47043262
139Vibrio cholerae infection_Homo sapiens_hsa051100.46336134
140mTOR signaling pathway_Homo sapiens_hsa041500.46299381
141Pancreatic secretion_Homo sapiens_hsa049720.46156718
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45527945
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.44751487
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44251997
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43995866
146Protein digestion and absorption_Homo sapiens_hsa049740.43426967
147Leishmaniasis_Homo sapiens_hsa051400.43069401
148Insulin secretion_Homo sapiens_hsa049110.40233539
149Insulin signaling pathway_Homo sapiens_hsa049100.40068876
150Viral carcinogenesis_Homo sapiens_hsa052030.39839961
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.39654626
152Acute myeloid leukemia_Homo sapiens_hsa052210.35791484
153AMPK signaling pathway_Homo sapiens_hsa041520.35397987
154Toxoplasmosis_Homo sapiens_hsa051450.35274558
155Glycerolipid metabolism_Homo sapiens_hsa005610.33885791
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32491943
157Glutathione metabolism_Homo sapiens_hsa004800.31926197
158Arginine and proline metabolism_Homo sapiens_hsa003300.31057535
159p53 signaling pathway_Homo sapiens_hsa041150.30604220
160Adherens junction_Homo sapiens_hsa045200.28961434
161Amoebiasis_Homo sapiens_hsa051460.24243440
162NF-kappa B signaling pathway_Homo sapiens_hsa040640.24084931
163Butanoate metabolism_Homo sapiens_hsa006500.24065766

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