ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	5.47270242
2	positive regulation of amino acid transport (GO:0051957)	5.03914987
3	histone H4-K12 acetylation (GO:0043983)	4.43236231
4	positive regulation of vesicle fusion (GO:0031340)	4.20799206
5	peptidyl-arginine N-methylation (GO:0035246)	4.01627930
6	peptidyl-arginine methylation (GO:0018216)	4.01627930
7	histone H2A acetylation (GO:0043968)	4.01331859
8	epithelial cilium movement (GO:0003351)	3.90834767
9	tongue development (GO:0043586)	3.85802439
10	regulation of feeding behavior (GO:0060259)	3.83699888
11	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.81659580
12	transmission of nerve impulse (GO:0019226)	3.79362493
13	auditory behavior (GO:0031223)	3.70697327
14	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.66265629
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53866773
16	motile cilium assembly (GO:0044458)	3.52290392
17	estrogen biosynthetic process (GO:0006703)	3.51216244
18	negative regulation of heart rate (GO:0010459)	3.40407081
19	regulation of cilium movement (GO:0003352)	3.36804793
20	short-term memory (GO:0007614)	3.35765182
21	tachykinin receptor signaling pathway (GO:0007217)	3.35505804
22	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.32953401
23	DNA methylation involved in gamete generation (GO:0043046)	3.31537754
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.29715541
25	protein polyglutamylation (GO:0018095)	3.28884130
26	regulation of glucokinase activity (GO:0033131)	3.24845266
27	regulation of hexokinase activity (GO:1903299)	3.24845266
28	head development (GO:0060322)	3.23398412
29	protein neddylation (GO:0045116)	3.22834953
30	dopaminergic neuron differentiation (GO:0071542)	3.16019018
31	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.11142986
32	substrate-independent telencephalic tangential migration (GO:0021826)	3.11142986
33	regulation of action potential (GO:0098900)	3.09097165
34	adult walking behavior (GO:0007628)	3.04873712
35	imidazole-containing compound metabolic process (GO:0052803)	3.03987542
36	cell migration in hindbrain (GO:0021535)	3.02406595
37	detection of light stimulus involved in visual perception (GO:0050908)	3.02211676
38	detection of light stimulus involved in sensory perception (GO:0050962)	3.02211676
39	positive regulation of protein targeting to membrane (GO:0090314)	2.96011404
40	mechanosensory behavior (GO:0007638)	2.94963540
41	sensory perception of taste (GO:0050909)	2.94752641
42	negative regulation of amino acid transport (GO:0051956)	2.93065760
43	acrosome reaction (GO:0007340)	2.93025604
44	positive regulation of protein homodimerization activity (GO:0090073)	2.90224003
45	regulation of synapse structural plasticity (GO:0051823)	2.89708951
46	white fat cell differentiation (GO:0050872)	2.89524305
47	axoneme assembly (GO:0035082)	2.89423276
48	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87603319
49	piRNA metabolic process (GO:0034587)	2.83267213
50	establishment of mitochondrion localization (GO:0051654)	2.83122704
51	neurofilament cytoskeleton organization (GO:0060052)	2.81815572
52	response to auditory stimulus (GO:0010996)	2.81494259
53	C4-dicarboxylate transport (GO:0015740)	2.81242268
54	behavioral response to nicotine (GO:0035095)	2.79705812
55	cerebellar granule cell differentiation (GO:0021707)	2.79497140
56	neuron recognition (GO:0008038)	2.75877997
57	neuronal action potential (GO:0019228)	2.75745532
58	parturition (GO:0007567)	2.74439062
59	peptidyl-arginine omega-N-methylation (GO:0035247)	2.73424282
60	peristalsis (GO:0030432)	2.73344146
61	negative regulation of telomere maintenance (GO:0032205)	2.73070438
62	axonemal dynein complex assembly (GO:0070286)	2.72457483
63	adaptation of signaling pathway (GO:0023058)	2.71499506
64	positive regulation of synapse assembly (GO:0051965)	2.71497779
65	cilium movement (GO:0003341)	2.69088654
66	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.67685335
67	regulation of translation, ncRNA-mediated (GO:0045974)	2.67573785
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.67573785
69	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.67573785
70	positive regulation of mitochondrial fission (GO:0090141)	2.67274003
71	positive regulation of amine transport (GO:0051954)	2.66368074
72	prepulse inhibition (GO:0060134)	2.66098490
73	resolution of meiotic recombination intermediates (GO:0000712)	2.65236971
74	response to misfolded protein (GO:0051788)	2.64935975
75	cell differentiation in hindbrain (GO:0021533)	2.63404750
76	cerebellar Purkinje cell differentiation (GO:0021702)	2.61952856
77	centriole assembly (GO:0098534)	2.59526288
78	histone arginine methylation (GO:0034969)	2.58554846
79	positive regulation of synapse maturation (GO:0090129)	2.58478478
80	gamma-aminobutyric acid transport (GO:0015812)	2.57358666
81	nucleobase catabolic process (GO:0046113)	2.57338974
82	negative regulation of appetite (GO:0032099)	2.56790363
83	negative regulation of response to food (GO:0032096)	2.56790363
84	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.55639373
85	positive regulation of gastrulation (GO:2000543)	2.55221362
86	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.51144283
87	glycerophospholipid catabolic process (GO:0046475)	2.50478490
88	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.50199187
89	neuronal action potential propagation (GO:0019227)	2.50098945
90	neuronal ion channel clustering (GO:0045161)	2.49438877
91	synaptic transmission, glutamatergic (GO:0035249)	2.46637334
92	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.46613369
93	detection of calcium ion (GO:0005513)	2.46007170
94	regulation of vesicle fusion (GO:0031338)	2.45767778
95	cerebral cortex radially oriented cell migration (GO:0021799)	2.45698800
96	startle response (GO:0001964)	2.44715740
97	regulation of microtubule-based movement (GO:0060632)	2.43904263
98	sperm motility (GO:0030317)	2.43382972
99	behavioral response to cocaine (GO:0048148)	2.42631692
100	protein K6-linked ubiquitination (GO:0085020)	2.41351585

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.60455243
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.27415830
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.98359685
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.66565949
5	VDR_22108803_ChIP-Seq_LS180_Human	2.40872472
6	REST_21632747_ChIP-Seq_MESCs_Mouse	2.34742980
7	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.26913984
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.26127722
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.25759465
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18453538
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.10859581
12	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.03619020
13	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.97097714
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.93933129
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.93378187
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.91913184
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.87613555
18	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.86524558
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.81309414
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.80968847
21	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.71096676
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.70697224
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67376101
24	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65537665
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.60924489
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.59141905
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.59141905
28	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56561347
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.55366591
30	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.54447742
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.52101338
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.50720175
33	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.50335824
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47036824
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46816239
36	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.41285778
37	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.40679625
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.40372890
39	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.40053516
40	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.38151249
41	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.33680541
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.32327224
43	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26356206
44	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.26214423
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.26173472
46	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23911333
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22717951
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22717951
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18107880
50	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.16949986
51	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.16379424
52	FUS_26573619_Chip-Seq_HEK293_Human	1.16110889
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.15163595
54	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14689070
55	P68_20966046_ChIP-Seq_HELA_Human	1.14375103
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11602347
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11435822
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.10409703
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08300351
60	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.07765167
61	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.07737313
62	ERA_21632823_ChIP-Seq_H3396_Human	1.07562957
63	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06958482
64	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04898549
65	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04300323
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.04289128
67	PHF8_20622854_ChIP-Seq_HELA_Human	1.03481293
68	AR_25329375_ChIP-Seq_VCAP_Human	1.02720813
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01805644
70	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.00540380
71	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.00318050
72	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.99675314
73	E2F1_20622854_ChIP-Seq_HELA_Human	0.97878542
74	JUN_21703547_ChIP-Seq_K562_Human	0.97826476
75	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97478958
76	MYC_19829295_ChIP-Seq_ESCs_Human	0.97124931
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96851002
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96785289
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96424336
80	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95666310
81	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.95433416
82	EWS_26573619_Chip-Seq_HEK293_Human	0.94982401
83	RAC3_21632823_ChIP-Seq_H3396_Human	0.92789781
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92583604
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91396958
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89768195
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89762422
88	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.89724692
89	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.89060380
90	TP53_22573176_ChIP-Seq_HFKS_Human	0.87996379
91	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.87507985
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.86764990
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.86016675
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.85408296
95	P300_19829295_ChIP-Seq_ESCs_Human	0.83722554
96	XRN2_22483619_ChIP-Seq_HELA_Human	0.83401009
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.82467874
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.82467874
99	RXR_22108803_ChIP-Seq_LS180_Human	0.82307517
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.82194952

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.72211698
2	MP0005423_abnormal_somatic_nervous	2.83940396
3	MP0002160_abnormal_reproductive_system	2.66283962
4	MP0001905_abnormal_dopamine_level	2.54907987
5	MP0003787_abnormal_imprinting	2.54019639
6	MP0001968_abnormal_touch/_nociception	2.39934550
7	MP0001485_abnormal_pinna_reflex	2.36789871
8	MP0008789_abnormal_olfactory_epithelium	2.27294316
9	MP0003878_abnormal_ear_physiology	2.25664369
10	MP0005377_hearing/vestibular/ear_phenot	2.25664369
11	MP0004147_increased_porphyrin_level	2.24913884
12	MP0004885_abnormal_endolymph	2.22874753
13	MP0001486_abnormal_startle_reflex	2.21275183
14	MP0001529_abnormal_vocalization	2.14061991
15	MP0002184_abnormal_innervation	2.12891330
16	MP0002272_abnormal_nervous_system	2.10084835
17	MP0006276_abnormal_autonomic_nervous	2.09259537
18	MP0002102_abnormal_ear_morphology	1.93400764
19	MP0006292_abnormal_olfactory_placode	1.91601380
20	MP0003635_abnormal_synaptic_transmissio	1.89793232
21	MP0009046_muscle_twitch	1.82626333
22	MP0000427_abnormal_hair_cycle	1.78394247
23	MP0002735_abnormal_chemical_nociception	1.77459809
24	MP0009745_abnormal_behavioral_response	1.76001138
25	MP0003136_yellow_coat_color	1.74871093
26	MP0002736_abnormal_nociception_after	1.71465431
27	MP0002572_abnormal_emotion/affect_behav	1.71051592
28	MP0005551_abnormal_eye_electrophysiolog	1.67777214
29	MP0000778_abnormal_nervous_system	1.67356380
30	MP0005379_endocrine/exocrine_gland_phen	1.66634794
31	MP0005499_abnormal_olfactory_system	1.62512024
32	MP0005394_taste/olfaction_phenotype	1.62512024
33	MP0002234_abnormal_pharynx_morphology	1.61935419
34	MP0002163_abnormal_gland_morphology	1.61896605
35	MP0000955_abnormal_spinal_cord	1.59424004
36	MP0001188_hyperpigmentation	1.59320571
37	MP0003879_abnormal_hair_cell	1.54300817
38	MP0000566_synostosis	1.54149157
39	MP0001986_abnormal_taste_sensitivity	1.53199642
40	MP0004859_abnormal_synaptic_plasticity	1.52270640
41	MP0002063_abnormal_learning/memory/cond	1.50488145
42	MP0002734_abnormal_mechanical_nocicepti	1.47265105
43	MP0005389_reproductive_system_phenotype	1.46388412
44	MP0002067_abnormal_sensory_capabilities	1.45777483
45	MP0002064_seizures	1.35387825
46	MP0004270_analgesia	1.30738736
47	MP0002210_abnormal_sex_determination	1.28898635
48	MP0000026_abnormal_inner_ear	1.27929474
49	MP0001970_abnormal_pain_threshold	1.27825510
50	MP0000049_abnormal_middle_ear	1.27179178
51	MP0004133_heterotaxia	1.25848360
52	MP0002653_abnormal_ependyma_morphology	1.25660143
53	MP0005409_darkened_coat_color	1.21584870
54	MP0002557_abnormal_social/conspecific_i	1.20291122
55	MP0001849_ear_inflammation	1.18416130
56	MP0003938_abnormal_ear_development	1.18191247
57	MP0002733_abnormal_thermal_nociception	1.17603902
58	MP0003693_abnormal_embryo_hatching	1.16786760
59	MP0002882_abnormal_neuron_morphology	1.14979573
60	MP0004019_abnormal_vitamin_homeostasis	1.14973066
61	MP0003698_abnormal_male_reproductive	1.12346075
62	MP0000678_abnormal_parathyroid_gland	1.10756736
63	MP0005410_abnormal_fertilization	1.09930987
64	MP0009379_abnormal_foot_pigmentation	1.09674572
65	MP0002752_abnormal_somatic_nervous	1.09516003
66	MP0003303_peritoneal_inflammation	1.08495448
67	MP0001963_abnormal_hearing_physiology	1.07016583
68	MP0002152_abnormal_brain_morphology	1.04736324
69	MP0002822_catalepsy	1.04599130
70	MP0002233_abnormal_nose_morphology	1.03330356
71	MP0008875_abnormal_xenobiotic_pharmacok	1.03146957
72	MP0003121_genomic_imprinting	1.03096568
73	MP0003861_abnormal_nervous_system	1.02886690
74	MP0003123_paternal_imprinting	0.94669077
75	MP0000631_abnormal_neuroendocrine_gland	0.94545891
76	MP0004742_abnormal_vestibular_system	0.94491226
77	MP0004142_abnormal_muscle_tone	0.93177409
78	MP0003122_maternal_imprinting	0.92062995
79	MP0008058_abnormal_DNA_repair	0.90187118
80	MP0003755_abnormal_palate_morphology	0.88680289
81	MP0002066_abnormal_motor_capabilities/c	0.87066002
82	MP0005386_behavior/neurological_phenoty	0.86330981
83	MP0004924_abnormal_behavior	0.86330981
84	MP0001929_abnormal_gametogenesis	0.85918330
85	MP0002229_neurodegeneration	0.84929580
86	MP0001984_abnormal_olfaction	0.84817156
87	MP0002909_abnormal_adrenal_gland	0.83748769
88	MP0001348_abnormal_lacrimal_gland	0.83495673
89	MP0001145_abnormal_male_reproductive	0.80634410
90	MP0005195_abnormal_posterior_eye	0.79528183
91	MP0005645_abnormal_hypothalamus_physiol	0.79521474
92	MP0000613_abnormal_salivary_gland	0.78699260
93	MP0000653_abnormal_sex_gland	0.78662179
94	MP0001502_abnormal_circadian_rhythm	0.78268328
95	MP0008877_abnormal_DNA_methylation	0.77058332
96	MP0004811_abnormal_neuron_physiology	0.76623164
97	MP0003942_abnormal_urinary_system	0.75906191
98	MP0002938_white_spotting	0.73548222
99	MP0002693_abnormal_pancreas_physiology	0.73220836
100	MP0005220_abnormal_exocrine_pancreas	0.73030901

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.24476442
2	Nephronophthisis (HP:0000090)	3.95291793
3	Annular pancreas (HP:0001734)	3.42207276
4	Amblyopia (HP:0000646)	3.22504414
5	Medial flaring of the eyebrow (HP:0010747)	3.19054812
6	Increased hepatocellular lipid droplets (HP:0006565)	3.18884812
7	Gait imbalance (HP:0002141)	3.11372497
8	Progressive cerebellar ataxia (HP:0002073)	3.08832021
9	Abnormality of the renal medulla (HP:0100957)	3.07947444
10	Congenital stationary night blindness (HP:0007642)	2.96445037
11	Tubular atrophy (HP:0000092)	2.96138458
12	Congenital primary aphakia (HP:0007707)	2.90367716
13	Pancreatic fibrosis (HP:0100732)	2.89770883
14	Lipid accumulation in hepatocytes (HP:0006561)	2.87839929
15	Increased intramyocellular lipid droplets (HP:0012240)	2.83398234
16	Pancreatic cysts (HP:0001737)	2.79270604
17	Rib fusion (HP:0000902)	2.77915399
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.76722029
19	Neonatal hypoglycemia (HP:0001998)	2.69640921
20	True hermaphroditism (HP:0010459)	2.68770691
21	Nephrogenic diabetes insipidus (HP:0009806)	2.60299087
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.52753980
23	Delayed epiphyseal ossification (HP:0002663)	2.51149756
24	Chorioretinal atrophy (HP:0000533)	2.50283002
25	Occipital encephalocele (HP:0002085)	2.48063240
26	Renal Fanconi syndrome (HP:0001994)	2.47939854
27	Acute necrotizing encephalopathy (HP:0006965)	2.40838131
28	Vaginal atresia (HP:0000148)	2.36884184
29	Severe visual impairment (HP:0001141)	2.34586199
30	Proximal tubulopathy (HP:0000114)	2.32989535
31	Increased muscle lipid content (HP:0009058)	2.26612222
32	Enlarged epiphyses (HP:0010580)	2.25248376
33	Fetal akinesia sequence (HP:0001989)	2.25090010
34	Type 2 muscle fiber atrophy (HP:0003554)	2.24917983
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21951760
36	Absent/shortened dynein arms (HP:0200106)	2.21951760
37	Left ventricular hypertrophy (HP:0001712)	2.21831226
38	Mitochondrial inheritance (HP:0001427)	2.20760711
39	Genital tract atresia (HP:0001827)	2.20463190
40	Agitation (HP:0000713)	2.20034012
41	Asymmetric septal hypertrophy (HP:0001670)	2.19977014
42	Tubulointerstitial abnormality (HP:0001969)	2.16410405
43	Tubulointerstitial fibrosis (HP:0005576)	2.16076587
44	Acute lymphatic leukemia (HP:0006721)	2.15323500
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14364964
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.10053902
47	Cystic liver disease (HP:0006706)	2.09865686
48	Glycosuria (HP:0003076)	2.08402831
49	Abnormality of urine glucose concentration (HP:0011016)	2.08402831
50	Pendular nystagmus (HP:0012043)	2.07997040
51	Drooling (HP:0002307)	2.07934911
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.06570028
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06570028
54	Abolished electroretinogram (ERG) (HP:0000550)	2.06283841
55	Limb dystonia (HP:0002451)	2.04457611
56	Muscle fiber atrophy (HP:0100295)	2.03624692
57	Molar tooth sign on MRI (HP:0002419)	2.03020245
58	Abnormality of midbrain morphology (HP:0002418)	2.03020245
59	Poor coordination (HP:0002370)	2.02981537
60	Abnormality of the renal cortex (HP:0011035)	2.02821369
61	Hyperventilation (HP:0002883)	2.02485848
62	Bony spicule pigmentary retinopathy (HP:0007737)	2.01471023
63	Abnormal urine phosphate concentration (HP:0012599)	2.00704237
64	Acute encephalopathy (HP:0006846)	1.99110933
65	Neoplasm of the adrenal cortex (HP:0100641)	1.98909121
66	Retinitis pigmentosa (HP:0000510)	1.97389344
67	Abnormal ciliary motility (HP:0012262)	1.96296923
68	Joint stiffness (HP:0001387)	1.95899857
69	Focal motor seizures (HP:0011153)	1.90724408
70	Popliteal pterygium (HP:0009756)	1.90714258
71	Hyperphosphaturia (HP:0003109)	1.88776706
72	Sclerocornea (HP:0000647)	1.88514766
73	Increased CSF lactate (HP:0002490)	1.87757801
74	Abnormality of macular pigmentation (HP:0008002)	1.87086114
75	Visual hallucinations (HP:0002367)	1.86610512
76	Tubulointerstitial nephritis (HP:0001970)	1.84278781
77	Abnormality of renal resorption (HP:0011038)	1.83097399
78	Adrenal hypoplasia (HP:0000835)	1.82231819
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.80830061
80	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.80830061
81	Absent thumb (HP:0009777)	1.80364505
82	Thin bony cortex (HP:0002753)	1.79436930
83	Excessive salivation (HP:0003781)	1.79298838
84	Hepatoblastoma (HP:0002884)	1.78496728
85	Generalized aminoaciduria (HP:0002909)	1.78448108
86	Abnormal eating behavior (HP:0100738)	1.77044620
87	Specific learning disability (HP:0001328)	1.76210360
88	Progressive macrocephaly (HP:0004481)	1.74227114
89	Failure to thrive in infancy (HP:0001531)	1.73930709
90	Abnormality of DNA repair (HP:0003254)	1.72912190
91	Attenuation of retinal blood vessels (HP:0007843)	1.72821912
92	Hyperalaninemia (HP:0003348)	1.70722075
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.70722075
94	Abnormality of alanine metabolism (HP:0010916)	1.70722075
95	Inability to walk (HP:0002540)	1.70510483
96	Lower limb asymmetry (HP:0100559)	1.70441905
97	Abnormal biliary tract physiology (HP:0012439)	1.70065225
98	Bile duct proliferation (HP:0001408)	1.70065225
99	Congenital hepatic fibrosis (HP:0002612)	1.69545500
100	Abnormal drinking behavior (HP:0030082)	1.68768689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.74981064
2	PNCK	4.08672634
3	WEE1	3.61803449
4	MARK1	2.87373609
5	TRIM28	2.62427006
6	BRSK2	2.55429612
7	LATS1	2.54755598
8	NUAK1	2.40576404
9	VRK2	2.29814071
10	PINK1	2.21038853
11	CDK19	2.18928547
12	NEK1	2.18739708
13	MINK1	2.11011644
14	MAP3K12	2.06947359
15	NTRK3	1.98425659
16	CASK	1.96049915
17	BCR	1.69966923
18	MUSK	1.68776708
19	MAP2K4	1.59027382
20	TAF1	1.53840579
21	SIK2	1.43456665
22	BRSK1	1.35925784
23	PIM2	1.34841061
24	DYRK3	1.33838610
25	MAP3K4	1.31881925
26	UHMK1	1.30865877
27	NTRK2	1.29428041
28	FRK	1.27321050
29	MAPK15	1.23024244
30	RPS6KA4	1.22527873
31	DYRK2	1.21016656
32	NME1	1.20514039
33	TLK1	1.20394186
34	CSNK1G3	1.16782813
35	ADRBK2	1.14687761
36	EIF2AK1	1.14672045
37	EPHA2	1.13127941
38	MAP2K6	1.11730368
39	CSNK1G2	1.04920210
40	CDK3	1.02004077
41	MAP2K3	0.97896612
42	AURKA	0.97851620
43	CSNK1A1L	0.97354076
44	TYRO3	0.96964543
45	MET	0.92866959
46	EPHA4	0.92164103
47	PRKCG	0.84351141
48	DYRK1A	0.84089822
49	TSSK6	0.83072430
50	WNK4	0.82069544
51	DYRK1B	0.81529034
52	CSNK1G1	0.76470068
53	PRKCI	0.74775390
54	TNIK	0.74362009
55	CCNB1	0.72591213
56	MAPK4	0.71334927
57	PRKD3	0.69432409
58	CAMK1G	0.68113300
59	MAP3K11	0.67328909
60	ARAF	0.66460790
61	MAP2K2	0.66029634
62	RPS6KA2	0.64272280
63	CAMK1D	0.63962647
64	TXK	0.63452636
65	INSRR	0.60973065
66	MAP3K9	0.60270880
67	PRKD2	0.60169667
68	BMPR1B	0.59538899
69	NTRK1	0.58582701
70	CSNK1E	0.57949872
71	GRK1	0.56770356
72	BCKDK	0.55436107
73	MAP3K6	0.53881472
74	MAPK8	0.52336645
75	PAK3	0.51943667
76	CHEK2	0.49867209
77	VRK1	0.47770538
78	CDK5	0.47398209
79	MAPK13	0.45954636
80	CSNK1A1	0.43954929
81	WNK3	0.43890027
82	CAMK1	0.43603841
83	EPHB2	0.43493135
84	BUB1	0.41421515
85	LIMK1	0.40209662
86	PTK2B	0.39596146
87	BMX	0.39433706
88	ERBB4	0.37967047
89	PRKG1	0.37576725
90	PRKCE	0.36535411
91	ABL2	0.36149039
92	STK11	0.34712105
93	PRKACA	0.33175416
94	STK39	0.33016522
95	PRKDC	0.31672207
96	TAOK1	0.30734756
97	PRKCH	0.30727122
98	CAMK2G	0.28751927
99	BTK	0.27687055
100	OXSR1	0.27420964

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.40339567
2	Nicotine addiction_Homo sapiens_hsa05033	3.13272202
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.60524952
4	Phototransduction_Homo sapiens_hsa04744	2.49189665
5	GABAergic synapse_Homo sapiens_hsa04727	2.30309819
6	Glutamatergic synapse_Homo sapiens_hsa04724	2.19971420
7	RNA polymerase_Homo sapiens_hsa03020	2.04039770
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.94650770
9	Parkinsons disease_Homo sapiens_hsa05012	1.86921141
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78343736
11	Insulin secretion_Homo sapiens_hsa04911	1.76530524
12	Morphine addiction_Homo sapiens_hsa05032	1.67469798
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66738166
14	Basal transcription factors_Homo sapiens_hsa03022	1.65067285
15	Axon guidance_Homo sapiens_hsa04360	1.64924831
16	Homologous recombination_Homo sapiens_hsa03440	1.64511795
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.61223943
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60195921
19	Sulfur relay system_Homo sapiens_hsa04122	1.58959942
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.54313154
21	Asthma_Homo sapiens_hsa05310	1.50816089
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.50426158
23	Circadian entrainment_Homo sapiens_hsa04713	1.49746928
24	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.47615346
25	Taste transduction_Homo sapiens_hsa04742	1.44946705
26	Ribosome_Homo sapiens_hsa03010	1.43529086
27	Cocaine addiction_Homo sapiens_hsa05030	1.41519684
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39219044
29	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.28900565
30	Amphetamine addiction_Homo sapiens_hsa05031	1.28817695
31	Alzheimers disease_Homo sapiens_hsa05010	1.25579899
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25530553
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25015570
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.24765580
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.24435438
36	Phenylalanine metabolism_Homo sapiens_hsa00360	1.21117724
37	Huntingtons disease_Homo sapiens_hsa05016	1.19843851
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18019863
39	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.15962438
40	Serotonergic synapse_Homo sapiens_hsa04726	1.15709041
41	Calcium signaling pathway_Homo sapiens_hsa04020	1.14953726
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12056088
43	Salivary secretion_Homo sapiens_hsa04970	1.08793146
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.06604736
45	Sulfur metabolism_Homo sapiens_hsa00920	1.02372259
46	RNA transport_Homo sapiens_hsa03013	1.01689708
47	Circadian rhythm_Homo sapiens_hsa04710	0.98741963
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98042561
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95702759
50	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95138949
51	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.91921131
52	Long-term potentiation_Homo sapiens_hsa04720	0.91519807
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91480419
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.89646295
55	Olfactory transduction_Homo sapiens_hsa04740	0.88379139
56	Oocyte meiosis_Homo sapiens_hsa04114	0.85795402
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.84185918
58	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82926647
59	Renin-angiotensin system_Homo sapiens_hsa04614	0.82758672
60	Peroxisome_Homo sapiens_hsa04146	0.81933555
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80505529
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80219455
63	Regulation of autophagy_Homo sapiens_hsa04140	0.78984151
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.74846607
65	Butanoate metabolism_Homo sapiens_hsa00650	0.74782944
66	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.74385174
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73994579
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.72581604
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.66790007
70	Long-term depression_Homo sapiens_hsa04730	0.65967287
71	Gastric acid secretion_Homo sapiens_hsa04971	0.65766527
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.63440408
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.63197749
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62921269
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61894071
76	VEGF signaling pathway_Homo sapiens_hsa04370	0.61824042
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61066046
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.59629242
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56943960
80	Lysine degradation_Homo sapiens_hsa00310	0.56599690
81	RNA degradation_Homo sapiens_hsa03018	0.55529147
82	Retinol metabolism_Homo sapiens_hsa00830	0.55509723
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54392787
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53939631
85	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53418446
86	Renin secretion_Homo sapiens_hsa04924	0.53105859
87	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51624618
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.51235242
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51025421
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50955455
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50798366
92	Metabolic pathways_Homo sapiens_hsa01100	0.50474601
93	Purine metabolism_Homo sapiens_hsa00230	0.50467002
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49056639
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47736019
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.44613711
97	Cholinergic synapse_Homo sapiens_hsa04725	0.42629118
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42073245
99	Gap junction_Homo sapiens_hsa04540	0.42070172
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41904780

TMEM249

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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