TMEM251

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.95813264
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76628564
3cullin deneddylation (GO:0010388)4.63482513
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62304147
5chaperone-mediated protein transport (GO:0072321)4.35185482
6protein neddylation (GO:0045116)4.22973176
7protein deneddylation (GO:0000338)4.20854022
8respiratory chain complex IV assembly (GO:0008535)4.16782393
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16667239
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14801250
11ATP synthesis coupled proton transport (GO:0015986)4.14801250
12signal peptide processing (GO:0006465)4.05699217
13neutrophil activation involved in immune response (GO:0002283)4.03847620
14cytochrome complex assembly (GO:0017004)3.98192827
15respiratory electron transport chain (GO:0022904)3.83515324
16DNA double-strand break processing (GO:0000729)3.81216377
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79332750
18electron transport chain (GO:0022900)3.76500792
19ribosomal small subunit assembly (GO:0000028)3.76287174
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76259811
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76036365
22negative regulation of ligase activity (GO:0051352)3.76036365
23platelet dense granule organization (GO:0060155)3.74012809
24ATP hydrolysis coupled proton transport (GO:0015991)3.67198999
25energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.67198999
26rRNA modification (GO:0000154)3.66743991
27regulation of mitochondrial translation (GO:0070129)3.63849599
28protein targeting to mitochondrion (GO:0006626)3.52984771
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.47846723
30NADH dehydrogenase complex assembly (GO:0010257)3.47846723
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47846723
32pseudouridine synthesis (GO:0001522)3.36580542
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35606975
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.35606975
35establishment of protein localization to mitochondrion (GO:0072655)3.34989422
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.34232726
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33482780
38water-soluble vitamin biosynthetic process (GO:0042364)3.32510817
39protein localization to mitochondrion (GO:0070585)3.30551955
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25969949
41proteasome assembly (GO:0043248)3.20848241
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19281354
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19177630
44positive regulation of ligase activity (GO:0051351)3.17963848
45lactate metabolic process (GO:0006089)3.17083563
46spliceosomal snRNP assembly (GO:0000387)3.15338648
47rRNA methylation (GO:0031167)3.12640163
48telomere maintenance via semi-conservative replication (GO:0032201)3.10562989
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10220697
50protein targeting to ER (GO:0045047)3.09704415
51cotranslational protein targeting to membrane (GO:0006613)3.08795407
52oxidative phosphorylation (GO:0006119)3.08578132
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03863846
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03863846
55ribosomal large subunit biogenesis (GO:0042273)3.01619157
56protein localization to endoplasmic reticulum (GO:0070972)3.00472669
57Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99851981
58C-terminal protein lipidation (GO:0006501)2.99481467
59folic acid-containing compound biosynthetic process (GO:0009396)2.99103407
60maturation of 5.8S rRNA (GO:0000460)2.98294065
61hydrogen ion transmembrane transport (GO:1902600)2.97752533
62positive regulation of gamma-delta T cell activation (GO:0046645)2.96209920
63regulation of ubiquitin-protein transferase activity (GO:0051438)2.94727834
64maturation of SSU-rRNA (GO:0030490)2.93794935
65DNA catabolic process, exonucleolytic (GO:0000738)2.92690309
66regulation of B cell receptor signaling pathway (GO:0050855)2.92478134
67telomere maintenance via recombination (GO:0000722)2.91137690
68oligosaccharide catabolic process (GO:0009313)2.90542751
69establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90489440
70viral transcription (GO:0019083)2.89759494
71translational termination (GO:0006415)2.89455994
72regulation of ligase activity (GO:0051340)2.89378820
73respiratory burst (GO:0045730)2.88104285
74purine deoxyribonucleotide catabolic process (GO:0009155)2.86247975
75immunoglobulin mediated immune response (GO:0016064)2.85056562
76antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.84447098
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83778546
78CENP-A containing nucleosome assembly (GO:0034080)2.82556696
79chromatin remodeling at centromere (GO:0031055)2.82275156
80GTP biosynthetic process (GO:0006183)2.81972887
81termination of RNA polymerase III transcription (GO:0006386)2.81937365
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.81937365
83mannosylation (GO:0097502)2.81831960
84regulation of cellular amine metabolic process (GO:0033238)2.81521643
85negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.81107850
86inositol phosphate dephosphorylation (GO:0046855)2.79822922
87phosphorylated carbohydrate dephosphorylation (GO:0046838)2.79822922
88DNA strand elongation involved in DNA replication (GO:0006271)2.79566318
89proton transport (GO:0015992)2.79159974
90inositol phosphate catabolic process (GO:0071545)2.78817781
91purine nucleotide salvage (GO:0032261)2.77433993
92C-terminal protein amino acid modification (GO:0018410)2.75802804
93negative regulation of protein ubiquitination (GO:0031397)2.74686029
94endosome to melanosome transport (GO:0035646)2.73934801
95endosome to pigment granule transport (GO:0043485)2.73934801
96hydrogen transport (GO:0006818)2.72947769
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72233434
98phagosome maturation (GO:0090382)2.72001568
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71790649
100DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68360531
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68297957
102deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66639280
103purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66485552
104dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.64440955
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63255482
106mitochondrial transport (GO:0006839)2.63227988
107inner mitochondrial membrane organization (GO:0007007)2.62524708
108positive regulation of cell cycle arrest (GO:0071158)2.62323824
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62314074
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62314074
111DNA replication checkpoint (GO:0000076)2.62221429
112DNA strand elongation (GO:0022616)2.62128203
113purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61784863
114interferon-gamma production (GO:0032609)2.61704239
115ATP biosynthetic process (GO:0006754)2.61594814
116translation (GO:0006412)2.61067245
117membrane lipid catabolic process (GO:0046466)2.60729325
118negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.60434201
119ribonucleoprotein complex biogenesis (GO:0022613)2.60261751
120sphingolipid catabolic process (GO:0030149)2.59578661
121nucleobase-containing small molecule interconversion (GO:0015949)2.59128614
122pteridine-containing compound biosynthetic process (GO:0042559)2.57591006
123translational elongation (GO:0006414)2.57013219
124purine nucleobase biosynthetic process (GO:0009113)2.55768764
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.55740579
126response to peptidoglycan (GO:0032494)2.54612191
127B cell mediated immunity (GO:0019724)2.54181278
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53939244
129translational initiation (GO:0006413)2.53130643
130peptidyl-histidine modification (GO:0018202)2.52563494
131protein complex biogenesis (GO:0070271)2.51274969
132ribosome biogenesis (GO:0042254)2.51232968
133regulation of RIG-I signaling pathway (GO:0039535)2.50619051
134rRNA processing (GO:0006364)2.50367482
135ribosomal small subunit biogenesis (GO:0042274)2.47590868
136negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46481892
137mitotic recombination (GO:0006312)2.46419661
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43065593
139ribosome assembly (GO:0042255)2.42726789
140cellular response to interferon-beta (GO:0035458)2.42591690
141positive regulation of interferon-alpha production (GO:0032727)2.42397089
142regulation of B cell differentiation (GO:0045577)2.42369290
143rRNA metabolic process (GO:0016072)2.41216163
144deoxyribonucleotide catabolic process (GO:0009264)2.40252697
145leukocyte aggregation (GO:0070486)2.39670850
146neutrophil activation (GO:0042119)2.39334797
147positive regulation of B cell differentiation (GO:0045579)2.38646100
148actin nucleation (GO:0045010)2.38556618
149viral life cycle (GO:0019058)2.37771740
150nucleobase biosynthetic process (GO:0046112)2.37395725
151defense response to protozoan (GO:0042832)2.37348068
152regulation of cellular amino acid metabolic process (GO:0006521)2.37209811
153reactive oxygen species biosynthetic process (GO:1903409)2.36691001
154positive regulation of macrophage differentiation (GO:0045651)2.36383580
155hydrogen peroxide biosynthetic process (GO:0050665)2.35854783
156granulocyte activation (GO:0036230)2.35646033
157DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.35498807
158deoxyribose phosphate biosynthetic process (GO:0046385)2.34340029
1592-deoxyribonucleotide biosynthetic process (GO:0009265)2.34340029
160mitochondrial respiratory chain complex assembly (GO:0033108)2.34271650
161response to protozoan (GO:0001562)2.34133609
162formation of translation preinitiation complex (GO:0001731)2.34091370
163chaperone mediated protein folding requiring cofactor (GO:0051085)2.33352313
164negative regulation of myeloid cell apoptotic process (GO:0033033)2.32998420
165glycosphingolipid catabolic process (GO:0046479)2.31985493
166signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.31581570
167intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.31581570
168cellular component biogenesis (GO:0044085)2.31121434
169signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.31087453
170signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.31087453
171signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.31087453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16192570
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31888327
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.29156236
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.27419144
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24561775
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22994057
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.21575880
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.93923873
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87375766
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79891732
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75429960
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.63385409
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.56994975
14VDR_23849224_ChIP-Seq_CD4+_Human2.52902188
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51280832
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.44448868
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43445795
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42501611
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.38228824
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27246245
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26562482
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24485891
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20818040
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20694552
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16876160
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.15329785
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14260484
28HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12720889
29* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09806755
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08404449
31DCP1A_22483619_ChIP-Seq_HELA_Human2.08348198
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.03229821
33ELK1_19687146_ChIP-ChIP_HELA_Human2.01990206
34SPI1_23547873_ChIP-Seq_NB4_Human2.01367043
35FOXP3_21729870_ChIP-Seq_TREG_Human1.96073398
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94733755
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94448219
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.93208566
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90803434
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90705237
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90177721
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83752120
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82331953
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81291520
45GABP_19822575_ChIP-Seq_HepG2_Human1.80599544
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79716842
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78675986
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76361885
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72705231
50TTF2_22483619_ChIP-Seq_HELA_Human1.68452193
51XRN2_22483619_ChIP-Seq_HELA_Human1.68238975
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63847957
53ZNF274_21170338_ChIP-Seq_K562_Hela1.62122938
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61719464
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61223852
56TFEB_21752829_ChIP-Seq_HELA_Human1.57822370
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57283127
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55078763
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50217822
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.49515830
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47554354
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.47512459
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46980938
64MYC_18940864_ChIP-ChIP_HL60_Human1.44718090
65MYB_26560356_Chip-Seq_TH2_Human1.40573209
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.39490279
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35798625
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34551255
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.33335691
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32984337
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.32420214
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32347444
73MYC_22102868_ChIP-Seq_BL_Human1.31919840
74SCL_19346495_ChIP-Seq_HPC-7_Human1.30091311
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29855415
76MYB_26560356_Chip-Seq_TH1_Human1.28263287
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28001812
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27933980
79VDR_22108803_ChIP-Seq_LS180_Human1.27443443
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.26174363
81IGF1R_20145208_ChIP-Seq_DFB_Human1.23255394
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22511200
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22247933
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20862292
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20006970
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18559905
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16720266
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16258921
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15788768
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.15772051
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15215941
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14374360
93VDR_21846776_ChIP-Seq_THP-1_Human1.14065590
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11540793
95GATA1_22025678_ChIP-Seq_K562_Human1.11195594
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10506297
97MAF_26560356_Chip-Seq_TH1_Human1.09693581
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06489163
99KDM5A_27292631_Chip-Seq_BREAST_Human1.06066995
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04461171
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04449587
102UTX_26944678_Chip-Seq_JUKART_Human1.03967582
103VDR_24763502_ChIP-Seq_THP-1_Human1.03778152
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03298631
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02907526
106CIITA_25753668_ChIP-Seq_RAJI_Human1.01155294
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98533052
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98504768
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98431840
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98059397
111ELF5_23300383_ChIP-Seq_T47D_Human0.96146908
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94457073
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93956965
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93045583
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92493556
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91637893
117EWS_26573619_Chip-Seq_HEK293_Human0.91183159
118HTT_18923047_ChIP-ChIP_STHdh_Human0.87295775
119TP53_22573176_ChIP-Seq_HFKS_Human0.84308737
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82467912
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82289246
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.78807378
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77506122
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76353952
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.74912546
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74815087
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73905062
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.73314558
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73292090
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72822237
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.72297414
132FUS_26573619_Chip-Seq_HEK293_Human0.71814774
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.71515799
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71384014
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70973748
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70107553
137AR_20517297_ChIP-Seq_VCAP_Human0.69702783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.52997465
2MP0001835_abnormal_antigen_presentation3.49135558
3MP0003693_abnormal_embryo_hatching2.99590340
4MP0005671_abnormal_response_to2.90605231
5MP0003724_increased_susceptibility_to2.89614658
6MP0009785_altered_susceptibility_to2.77899226
7MP0003436_decreased_susceptibility_to2.70714000
8MP0002139_abnormal_hepatobiliary_system2.69604695
9MP0005000_abnormal_immune_tolerance2.58697395
10MP0002102_abnormal_ear_morphology2.56437657
11MP0003763_abnormal_thymus_physiology2.42417904
12MP0005379_endocrine/exocrine_gland_phen2.37350255
13MP0002396_abnormal_hematopoietic_system2.36009632
14MP0002090_abnormal_vision2.35882411
15MP0009333_abnormal_splenocyte_physiolog2.35509068
16MP0002419_abnormal_innate_immunity2.33696125
17MP0005075_abnormal_melanosome_morpholog2.33302693
18MP0002148_abnormal_hypersensitivity_rea2.29711413
19MP0002452_abnormal_antigen_presenting2.28174859
20MP0005025_abnormal_response_to2.22867375
21MP0002723_abnormal_immune_serum2.19586277
22MP0005387_immune_system_phenotype2.14315408
23MP0001790_abnormal_immune_system2.14315408
24MP0002420_abnormal_adaptive_immunity2.13313791
25MP0001800_abnormal_humoral_immune2.12923061
26MP0005408_hypopigmentation2.12100472
27MP0001819_abnormal_immune_cell2.11125318
28MP0010234_abnormal_vibrissa_follicle2.03316405
29MP0005058_abnormal_lysosome_morphology2.01399244
30MP0001853_heart_inflammation2.00115269
31MP0002254_reproductive_system_inflammat1.99396660
32MP0002398_abnormal_bone_marrow1.95633410
33MP0006072_abnormal_retinal_apoptosis1.95079042
34MP0003303_peritoneal_inflammation1.93370849
35MP0002877_abnormal_melanocyte_morpholog1.92525345
36MP0004957_abnormal_blastocyst_morpholog1.91393965
37MP0008057_abnormal_DNA_replication1.89433379
38MP0000490_abnormal_crypts_of1.87984258
39MP0001764_abnormal_homeostasis1.84536945
40MP0002277_abnormal_respiratory_mucosa1.82839112
41MP0003186_abnormal_redox_activity1.82314784
42MP0009840_abnormal_foam_cell1.81560228
43MP0000685_abnormal_immune_system1.80525925
44MP0008007_abnormal_cellular_replicative1.79526086
45MP0002933_joint_inflammation1.79302919
46MP0000716_abnormal_immune_system1.78341647
47MP0000689_abnormal_spleen_morphology1.76963464
48MP0006082_CNS_inflammation1.74821578
49MP0010094_abnormal_chromosome_stability1.71964842
50MP0002722_abnormal_immune_system1.70832936
51MP0005253_abnormal_eye_physiology1.68846505
52MP0001545_abnormal_hematopoietic_system1.68565220
53MP0005397_hematopoietic_system_phenotyp1.68565220
54MP0008058_abnormal_DNA_repair1.68541754
55MP0006035_abnormal_mitochondrial_morpho1.67414015
56MP0002405_respiratory_system_inflammati1.67287886
57MP0005464_abnormal_platelet_physiology1.65784507
58MP0002166_altered_tumor_susceptibility1.64219533
59MP0002006_tumorigenesis1.61198381
60MP0003077_abnormal_cell_cycle1.60820799
61MP0000858_altered_metastatic_potential1.60183096
62MP0001845_abnormal_inflammatory_respons1.59404402
63MP0004510_myositis1.58501592
64MP0002429_abnormal_blood_cell1.58492666
65MP0002638_abnormal_pupillary_reflex1.57789888
66MP0002876_abnormal_thyroid_physiology1.56698640
67MP0001533_abnormal_skeleton_physiology1.55612064
68MP0000371_diluted_coat_color1.55458189
69MP0001851_eye_inflammation1.53509616
70MP0005174_abnormal_tail_pigmentation1.53042080
71MP0004808_abnormal_hematopoietic_stem1.51893613
72MP0009379_abnormal_foot_pigmentation1.51381278
73MP0003718_maternal_effect1.49782858
74MP0005084_abnormal_gallbladder_morpholo1.48450287
75MP0002163_abnormal_gland_morphology1.48086703
76MP0003011_delayed_dark_adaptation1.47485227
77MP0003111_abnormal_nucleus_morphology1.43463267
78MP0010155_abnormal_intestine_physiology1.42546803
79MP0003656_abnormal_erythrocyte_physiolo1.42529939
80MP0005365_abnormal_bile_salt1.42069342
81MP0008469_abnormal_protein_level1.36933927
82MP0001324_abnormal_eye_pigmentation1.36520185
83MP0000703_abnormal_thymus_morphology1.35343596
84MP0000015_abnormal_ear_pigmentation1.34683416
85MP0002938_white_spotting1.34595400
86MP0001529_abnormal_vocalization1.31908079
87MP0004019_abnormal_vitamin_homeostasis1.31278478
88MP0002132_abnormal_respiratory_system1.29499682
89MP0005332_abnormal_amino_acid1.25834182
90MP0005647_abnormal_sex_gland1.25328312
91MP0000516_abnormal_urinary_system1.23776101
92MP0005367_renal/urinary_system_phenotyp1.23776101
93MP0003868_abnormal_feces_composition1.20448344
94MP0010386_abnormal_urinary_bladder1.20207588
95MP0006054_spinal_hemorrhage1.19617015
96MP0001727_abnormal_embryo_implantation1.16281719
97MP0004147_increased_porphyrin_level1.15734947
98MP0003646_muscle_fatigue1.14996805
99MP0004947_skin_inflammation1.14853178
100MP0001984_abnormal_olfaction1.14828330
101MP0006036_abnormal_mitochondrial_physio1.13280773
102MP0002909_abnormal_adrenal_gland1.10783398
103MP0002998_abnormal_bone_remodeling1.10275622
104MP0002095_abnormal_skin_pigmentation1.09477258
105MP0009697_abnormal_copulation1.08615622
106MP0005310_abnormal_salivary_gland1.05566434
107MP0003448_altered_tumor_morphology1.05231610
108MP0002019_abnormal_tumor_incidence1.04298691
109MP0000343_altered_response_to1.03727714
110MP0003172_abnormal_lysosome_physiology1.03459211
111MP0000372_irregular_coat_pigmentation1.03349683
112MP0008877_abnormal_DNA_methylation1.01163916
113MP0003075_altered_response_to1.01006199
114MP0002693_abnormal_pancreas_physiology1.00927001
115MP0000313_abnormal_cell_death0.99843130
116MP0000604_amyloidosis0.98801891
117MP0003136_yellow_coat_color0.98658579
118MP0003183_abnormal_peptide_metabolism0.98587943
119MP0003866_abnormal_defecation0.97016516
120MP0003795_abnormal_bone_structure0.96968495
121MP0005319_abnormal_enzyme/_coenzyme0.95953650
122MP0001542_abnormal_bone_strength0.95428580
123MP0000647_abnormal_sebaceous_gland0.92150560
124MP0009764_decreased_sensitivity_to0.89976840
125MP0003137_abnormal_impulse_conducting0.89819803
126MP0008789_abnormal_olfactory_epithelium0.88946305
127MP0001873_stomach_inflammation0.86714004
128MP0005171_absent_coat_pigmentation0.85686025
129MP0003890_abnormal_embryonic-extraembry0.84974430
130MP0000465_gastrointestinal_hemorrhage0.83988254
131MP0001756_abnormal_urination0.83853770
132MP0009046_muscle_twitch0.83175347
133MP0003786_premature_aging0.82263856
134MP0002751_abnormal_autonomic_nervous0.81770965
135MP0005390_skeleton_phenotype0.80462335
136MP0000358_abnormal_cell_content/0.80153159
137MP0005248_abnormal_Harderian_gland0.80058126
138MP0001348_abnormal_lacrimal_gland0.79437560
139MP0003828_pulmonary_edema0.78877788
140MP0005636_abnormal_mineral_homeostasis0.78874890
141MP0008932_abnormal_embryonic_tissue0.78138796
142MP0002229_neurodegeneration0.75612299
143MP0003787_abnormal_imprinting0.75130170
144MP0005220_abnormal_exocrine_pancreas0.74482384
145MP0003806_abnormal_nucleotide_metabolis0.73167425
146MP0002736_abnormal_nociception_after0.72876244
147MP0009763_increased_sensitivity_to0.72773891
148MP0003121_genomic_imprinting0.72060323
149MP0005076_abnormal_cell_differentiation0.71588420
150MP0003941_abnormal_skin_development0.71303643
151MP0003195_calcinosis0.70988043
152MP0000350_abnormal_cell_proliferation0.69655131
153MP0005167_abnormal_blood-brain_barrier0.69426598
154MP0010329_abnormal_lipoprotein_level0.68355099
155MP0010307_abnormal_tumor_latency0.68352096
156MP0004133_heterotaxia0.67902184
157MP0004215_abnormal_myocardial_fiber0.66873668
158MP0005551_abnormal_eye_electrophysiolog0.66378728
159MP0005451_abnormal_body_composition0.63828959
160MP0003191_abnormal_cellular_cholesterol0.63222852
161MP0001186_pigmentation_phenotype0.63127202
162MP0003123_paternal_imprinting0.62106331
163MP0001919_abnormal_reproductive_system0.61231600

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.42773540
2Recurrent abscess formation (HP:0002722)4.47675655
3Vacuolated lymphocytes (HP:0001922)4.24383601
4Acute encephalopathy (HP:0006846)4.14306226
5Progressive macrocephaly (HP:0004481)4.13436752
6Recurrent bacterial skin infections (HP:0005406)3.84347748
7Abnormality of macrophages (HP:0004311)3.70089317
8Eczematoid dermatitis (HP:0000976)3.65570957
9Increased hepatocellular lipid droplets (HP:0006565)3.58790397
10Abnormality of cells of the erythroid lineage (HP:0012130)3.54413179
11Petechiae (HP:0000967)3.52802681
12Oral leukoplakia (HP:0002745)3.51374454
13Renal Fanconi syndrome (HP:0001994)3.45245811
14Abnormal number of erythroid precursors (HP:0012131)3.44783138
15Reduced antithrombin III activity (HP:0001976)3.38507286
16Type I transferrin isoform profile (HP:0003642)3.36750681
17Lipid accumulation in hepatocytes (HP:0006561)3.36630395
18Stomatitis (HP:0010280)3.11897943
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.11382989
20Abnormal protein N-linked glycosylation (HP:0012347)3.11382989
21Abnormal protein glycosylation (HP:0012346)3.11382989
22Abnormal glycosylation (HP:0012345)3.11382989
23Elevated erythrocyte sedimentation rate (HP:0003565)3.11114072
24Cerebral edema (HP:0002181)3.05120077
25IgM deficiency (HP:0002850)3.04300168
26Loss of speech (HP:0002371)3.01947095
27Hepatocellular necrosis (HP:0001404)2.96555836
28Respiratory failure (HP:0002878)2.96119076
29Disinhibition (HP:0000734)2.94499120
30Mediastinal lymphadenopathy (HP:0100721)2.93789548
31Recurrent gram-negative bacterial infections (HP:0005420)2.85300646
32Lactic acidosis (HP:0003128)2.82119598
33Hepatic necrosis (HP:0002605)2.77774008
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66386523
35Increased intramyocellular lipid droplets (HP:0012240)2.64582126
36Chronic obstructive pulmonary disease (HP:0006510)2.62760773
37Obstructive lung disease (HP:0006536)2.62760773
38Myositis (HP:0100614)2.62590377
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.61381005
40Recurrent fungal infections (HP:0002841)2.59821721
41Poor head control (HP:0002421)2.57044304
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.55575729
43Rough bone trabeculation (HP:0100670)2.52141987
44Pancytopenia (HP:0001876)2.49018703
45Birth length less than 3rd percentile (HP:0003561)2.48547529
46Recurrent skin infections (HP:0001581)2.47891875
47Dysostosis multiplex (HP:0000943)2.47155204
48Recurrent bronchitis (HP:0002837)2.46541405
49Methylmalonic aciduria (HP:0012120)2.46295584
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43928191
51Methylmalonic acidemia (HP:0002912)2.43806701
52Recurrent viral infections (HP:0004429)2.41420205
53Hypoplasia of the fovea (HP:0007750)2.40527965
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.40527965
55Premature graying of hair (HP:0002216)2.37501761
56Abnormality of renal resorption (HP:0011038)2.36975043
57T lymphocytopenia (HP:0005403)2.36468258
58Mutism (HP:0002300)2.35671586
59Mitochondrial inheritance (HP:0001427)2.35617075
60IgG deficiency (HP:0004315)2.34834681
61Pulmonary fibrosis (HP:0002206)2.33765492
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32961915
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32961915
64Exercise intolerance (HP:0003546)2.32269284
65Neoplasm of the adrenal gland (HP:0100631)2.29365065
66Thrombocytosis (HP:0001894)2.26333653
67Testicular atrophy (HP:0000029)2.25593906
68Abnormality of T cells (HP:0002843)2.25266852
69Lethargy (HP:0001254)2.24503317
70Pallor (HP:0000980)2.24288082
71Increased cerebral lipofuscin (HP:0011813)2.24202146
72Chronic mucocutaneous candidiasis (HP:0002728)2.23760657
73Recurrent cutaneous fungal infections (HP:0011370)2.23760657
74Abnormality of T cell number (HP:0011839)2.23730723
75Microvesicular hepatic steatosis (HP:0001414)2.23174420
76Exertional dyspnea (HP:0002875)2.22419296
77Increased serum ferritin (HP:0003281)2.20488214
78Abnormality of methionine metabolism (HP:0010901)2.19765371
79Lymphoma (HP:0002665)2.18578610
80Lymphopenia (HP:0001888)2.17776853
81Agnosia (HP:0010524)2.17009463
82Increased muscle lipid content (HP:0009058)2.15808290
83CNS demyelination (HP:0007305)2.13958757
84Hypoglycemic coma (HP:0001325)2.13906806
85Abnormality of the fovea (HP:0000493)2.13867609
86Multiple enchondromatosis (HP:0005701)2.13811633
87Abnormality of T cell physiology (HP:0011840)2.10870338
88Optic disc pallor (HP:0000543)2.10026113
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09941264
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.06991281
91Abnormal spermatogenesis (HP:0008669)2.06936039
92Congenital malformation of the right heart (HP:0011723)2.06838053
93Double outlet right ventricle (HP:0001719)2.06838053
94Abnormality of B cell number (HP:0010975)2.06837813
95B lymphocytopenia (HP:0010976)2.06837813
96Severe combined immunodeficiency (HP:0004430)2.06539664
97Increased CSF lactate (HP:0002490)2.03401694
98Reticulocytopenia (HP:0001896)2.03275406
99Gingivitis (HP:0000230)2.02790183
100Chronic otitis media (HP:0000389)2.02039439
101Prolonged neonatal jaundice (HP:0006579)2.01557555
102Bone marrow hypocellularity (HP:0005528)2.01384379
103Symptomatic seizures (HP:0011145)2.00573290
104Albinism (HP:0001022)1.99662353
105Aplasia/Hypoplasia of the macula (HP:0008059)1.98617568
106Urinary glycosaminoglycan excretion (HP:0003541)1.98331628
107Mucopolysacchariduria (HP:0008155)1.98331628
108Increased serum lactate (HP:0002151)1.97269280
109Tongue fasciculations (HP:0001308)1.97147193
110Leukodystrophy (HP:0002415)1.96696553
111Abnormality of liposaccharide metabolism (HP:0010968)1.96195148
112Abnormality of glycosphingolipid metabolism (HP:0004343)1.96195148
113Abnormality of glycolipid metabolism (HP:0010969)1.96195148
114Generalized aminoaciduria (HP:0002909)1.95838230
115Pustule (HP:0200039)1.95766654
1163-Methylglutaconic aciduria (HP:0003535)1.94876825
117Hypokinesia (HP:0002375)1.94793884
118Meningitis (HP:0001287)1.94712465
119Abnormal trabecular bone morphology (HP:0100671)1.94525711
120Respiratory difficulties (HP:0002880)1.93918146
121Basal ganglia calcification (HP:0002135)1.90288940
122Abnormality of polysaccharide metabolism (HP:0011012)1.90134401
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90134401
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90134401
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90133646
126Macrocytic anemia (HP:0001972)1.89964305
127Progressive neurologic deterioration (HP:0002344)1.89885512
128Orchitis (HP:0100796)1.88765550
129Abnormality of the anterior horn cell (HP:0006802)1.86932930
130Degeneration of anterior horn cells (HP:0002398)1.86932930
131Irregular epiphyses (HP:0010582)1.85614271
132Nausea (HP:0002018)1.83841203
133Medial flaring of the eyebrow (HP:0010747)1.83612052
134Combined immunodeficiency (HP:0005387)1.83323529
135Blindness (HP:0000618)1.83314088
136Acute necrotizing encephalopathy (HP:0006965)1.83276041
137Colon cancer (HP:0003003)1.83020574
138Hypoglycemic seizures (HP:0002173)1.82855153
139Microretrognathia (HP:0000308)1.82641221
140Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82185624
141Abnormal mitochondria in muscle tissue (HP:0008316)1.81695782
142Hypoplasia of the thymus (HP:0000778)1.80690624
143Abnormality of urine glucose concentration (HP:0011016)1.80337850
144Glycosuria (HP:0003076)1.80337850
145Increased serum pyruvate (HP:0003542)1.80192895
146Leukocytosis (HP:0001974)1.79154980
147Autoimmune thrombocytopenia (HP:0001973)1.78835637
148Prolonged bleeding time (HP:0003010)1.78712005
149Abnormality of midbrain morphology (HP:0002418)1.78475300
150Molar tooth sign on MRI (HP:0002419)1.78475300
151Epistaxis (HP:0000421)1.78462565
152Retrobulbar optic neuritis (HP:0100654)1.76870950
153Optic neuritis (HP:0100653)1.76870950
154Atrophy/Degeneration involving motor neurons (HP:0007373)1.76343801
155Cellulitis (HP:0100658)1.76099582
156X-linked dominant inheritance (HP:0001423)1.74065775
157Prostate neoplasm (HP:0100787)1.73189406
158Abnormality of vitamin B metabolism (HP:0004340)1.71553518
159Hyperglycinemia (HP:0002154)1.70113318
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68919376
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68016975
162Nuclear cataract (HP:0100018)1.67427860
163Hyperinsulinemic hypoglycemia (HP:0000825)1.66819734
164Dicarboxylic aciduria (HP:0003215)1.66296083
165Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66296083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.42989648
2VRK23.45651392
3CDC72.91816589
4EIF2AK12.87201340
5EIF2AK32.74917351
6MAP4K22.72219250
7WNK32.66285562
8TRIM282.49493555
9IRAK42.44056903
10IRAK32.42892106
11FRK2.41025597
12PIM22.35472888
13MAP3K122.23699677
14TXK2.23086431
15STK162.19936307
16NUAK12.13874273
17BLK2.05754426
18MAP3K102.05073073
19MAP4K12.00787893
20WEE11.93884869
21MAP3K141.86537269
22TBK11.84247450
23CSNK1G31.80158252
24SCYL21.78271266
25PDK21.78237256
26SRPK11.77622630
27NEK91.73942704
28PLK31.72185971
29CSNK1G11.68935577
30VRK11.68687525
31KIT1.67119225
32JAK31.66602335
33ZAP701.65526941
34BUB11.64360801
35PBK1.62249046
36TEC1.60454362
37BRSK21.58322816
38ACVR1B1.57686757
39CSNK1G21.53264900
40PLK41.52857049
41KDR1.42182241
42ADRBK21.40375757
43BRAF1.39178952
44TLK11.36071747
45RPS6KA41.34584409
46CSNK1A1L1.34131836
47IKBKB1.33447861
48MAP3K111.33408526
49TYK21.32257758
50MAP2K21.30290207
51IKBKE1.26405558
52MAP3K41.25599593
53ERBB31.24085419
54MARK31.23116857
55MKNK21.19105984
56TNIK1.16466482
57MST41.16342347
58DYRK31.14470748
59LIMK11.13695525
60MAP3K31.12851886
61SYK1.10933806
62NEK11.09753373
63CAMKK21.09293987
64BTK1.08893151
65TAF11.07318544
66NLK1.05898848
67TAOK31.05038155
68RIPK41.00911175
69MAP2K70.97597001
70ERN10.96946797
71TGFBR10.96650517
72NME10.94572365
73PIM10.91390535
74BCR0.91294870
75ABL20.88648770
76DAPK10.88194866
77PLK20.88023550
78LYN0.87723409
79LCK0.86773196
80CDK80.86506850
81EIF2AK20.85835173
82CASK0.82780391
83DYRK20.81200567
84TTK0.80146861
85PAK40.78767749
86FLT30.78593313
87NEK20.78511571
88MKNK10.76840310
89TSSK60.76505776
90BMPR20.76046089
91ZAK0.74932989
92SIK30.68443763
93GRK10.66725800
94PLK10.64315000
95MAP2K30.63076711
96AURKB0.61714917
97FER0.61667346
98TGFBR20.59840623
99ATR0.58665334
100FGR0.58627124
101JAK10.57596905
102STK240.56447337
103PASK0.56285109
104ITK0.56009386
105PINK10.55589939
106MATK0.54877128
107BCKDK0.53848603
108CCNB10.52410686
109CAMK2D0.52099266
110PRKCG0.51825971
111TESK20.50762260
112TAOK10.50704980
113CDK30.50277786
114FES0.49907086
115HIPK20.49045164
116STK100.48960218
117CHEK20.48672928
118PRKCI0.47473206
119LRRK20.46471208
120TESK10.46212883
121CHUK0.46170801
122CSNK1A10.44637717
123IRAK10.44471047
124CSNK2A10.44257896
125ERBB40.43769132
126CDK70.43711463
127GRK60.43375877
128GRK70.43227501
129CSK0.43117581
130CSF1R0.42937177
131RPS6KA50.41763847
132CDK190.41176742
133STK38L0.41097540
134STK30.40984142
135PHKG20.39006471
136PHKG10.39006471
137CDK60.38726377
138PRKCE0.37228687
139MAP3K80.37042377
140PRKCD0.36945685
141STK40.36635253
142BMPR1B0.36059221
143IRAK20.34681296
144BRSK10.34285644
145AURKA0.32928937
146CSNK2A20.32223371
147GSK3A0.32129204
148ATM0.31996114
149MAP3K50.31898350
150JAK20.31770211
151CAMK2G0.30470118
152DAPK30.28980118
153OXSR10.27841975

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.12012573
2DNA replication_Homo sapiens_hsa030303.11140555
3Proteasome_Homo sapiens_hsa030503.09142797
4Protein export_Homo sapiens_hsa030603.03851541
5RNA polymerase_Homo sapiens_hsa030202.60913649
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48971006
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47164842
8Fatty acid elongation_Homo sapiens_hsa000622.43570219
9Mismatch repair_Homo sapiens_hsa034302.22480393
10Homologous recombination_Homo sapiens_hsa034402.16732106
11Other glycan degradation_Homo sapiens_hsa005112.10352023
12Vitamin B6 metabolism_Homo sapiens_hsa007502.00938929
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00539054
14Pyrimidine metabolism_Homo sapiens_hsa002402.00177384
15Base excision repair_Homo sapiens_hsa034101.90289375
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87113678
17Spliceosome_Homo sapiens_hsa030401.85160671
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78049061
19Steroid biosynthesis_Homo sapiens_hsa001001.74694674
20Oxidative phosphorylation_Homo sapiens_hsa001901.71905218
21Leishmaniasis_Homo sapiens_hsa051401.70632380
22Primary immunodeficiency_Homo sapiens_hsa053401.66481493
23Nucleotide excision repair_Homo sapiens_hsa034201.64562265
24Antigen processing and presentation_Homo sapiens_hsa046121.59766341
25Propanoate metabolism_Homo sapiens_hsa006401.58236881
26RNA degradation_Homo sapiens_hsa030181.56650949
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.55851399
28Legionellosis_Homo sapiens_hsa051341.53679812
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52600450
30Lysosome_Homo sapiens_hsa041421.48772587
31Glutathione metabolism_Homo sapiens_hsa004801.47511823
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43333367
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40612657
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37003727
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.35216408
36Rheumatoid arthritis_Homo sapiens_hsa053231.34924006
37RNA transport_Homo sapiens_hsa030131.34255818
38Basal transcription factors_Homo sapiens_hsa030221.33586118
39Parkinsons disease_Homo sapiens_hsa050121.31581369
40Measles_Homo sapiens_hsa051621.31086830
41Hematopoietic cell lineage_Homo sapiens_hsa046401.30782816
42Folate biosynthesis_Homo sapiens_hsa007901.29725904
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28797170
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27232689
45Herpes simplex infection_Homo sapiens_hsa051681.23139908
46Tuberculosis_Homo sapiens_hsa051521.23031743
47Non-homologous end-joining_Homo sapiens_hsa034501.20177460
48Purine metabolism_Homo sapiens_hsa002301.19459190
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16754319
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.14497121
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14020762
52Collecting duct acid secretion_Homo sapiens_hsa049661.13599818
53Pyruvate metabolism_Homo sapiens_hsa006201.11494361
54One carbon pool by folate_Homo sapiens_hsa006701.10856251
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.09093846
56Fanconi anemia pathway_Homo sapiens_hsa034601.08738112
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07914310
58Apoptosis_Homo sapiens_hsa042101.07224554
59Graft-versus-host disease_Homo sapiens_hsa053321.06349051
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05618350
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05443855
62Cell cycle_Homo sapiens_hsa041101.04827183
63Epstein-Barr virus infection_Homo sapiens_hsa051691.04787514
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04030268
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03802909
66Vibrio cholerae infection_Homo sapiens_hsa051101.03293573
67Sphingolipid metabolism_Homo sapiens_hsa006001.03149170
68Osteoclast differentiation_Homo sapiens_hsa043801.03012114
69Galactose metabolism_Homo sapiens_hsa000521.02093388
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99997738
71Huntingtons disease_Homo sapiens_hsa050160.98497888
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97377621
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.97109318
74p53 signaling pathway_Homo sapiens_hsa041150.96186829
75Peroxisome_Homo sapiens_hsa041460.95224316
76N-Glycan biosynthesis_Homo sapiens_hsa005100.94819328
77Asthma_Homo sapiens_hsa053100.94608078
78Phagosome_Homo sapiens_hsa041450.93613006
79Fatty acid metabolism_Homo sapiens_hsa012120.92974882
80Pertussis_Homo sapiens_hsa051330.91345701
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91274987
82Allograft rejection_Homo sapiens_hsa053300.87670043
83Metabolic pathways_Homo sapiens_hsa011000.86022230
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84158376
85B cell receptor signaling pathway_Homo sapiens_hsa046620.83808781
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83574637
87Shigellosis_Homo sapiens_hsa051310.82578565
88Influenza A_Homo sapiens_hsa051640.81894367
89Selenocompound metabolism_Homo sapiens_hsa004500.81751642
90Hepatitis B_Homo sapiens_hsa051610.81641554
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.81485719
92Malaria_Homo sapiens_hsa051440.80075471
93Butanoate metabolism_Homo sapiens_hsa006500.78501756
94Carbon metabolism_Homo sapiens_hsa012000.77292098
95Type I diabetes mellitus_Homo sapiens_hsa049400.76769588
96TNF signaling pathway_Homo sapiens_hsa046680.69206479
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69062839
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68934467
99Alzheimers disease_Homo sapiens_hsa050100.68406845
100Tryptophan metabolism_Homo sapiens_hsa003800.66304577
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65995317
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.65489517
103Pentose phosphate pathway_Homo sapiens_hsa000300.63707468
104Sulfur relay system_Homo sapiens_hsa041220.63521995
105T cell receptor signaling pathway_Homo sapiens_hsa046600.63157754
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62579688
107Sulfur metabolism_Homo sapiens_hsa009200.62409395
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60837737
109Viral carcinogenesis_Homo sapiens_hsa052030.60547014
110Fatty acid degradation_Homo sapiens_hsa000710.60093640
111Cardiac muscle contraction_Homo sapiens_hsa042600.58157401
112Thyroid cancer_Homo sapiens_hsa052160.57950130
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57329656
114beta-Alanine metabolism_Homo sapiens_hsa004100.56153654
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54503466
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50275746
117Synaptic vesicle cycle_Homo sapiens_hsa047210.49881876
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.48703350
119Acute myeloid leukemia_Homo sapiens_hsa052210.47933558
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47299380
121HTLV-I infection_Homo sapiens_hsa051660.44819037
122Toxoplasmosis_Homo sapiens_hsa051450.43400772
123Mineral absorption_Homo sapiens_hsa049780.41720130
124Ether lipid metabolism_Homo sapiens_hsa005650.39742315
125Salmonella infection_Homo sapiens_hsa051320.39350815
126Regulation of autophagy_Homo sapiens_hsa041400.38901525
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35696861
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33942624
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33752426
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33197807
131Staphylococcus aureus infection_Homo sapiens_hsa051500.32928150
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32722083
133Systemic lupus erythematosus_Homo sapiens_hsa053220.32707689
134Phototransduction_Homo sapiens_hsa047440.31099071
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31050299
136Fructose and mannose metabolism_Homo sapiens_hsa000510.30992402
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28648371
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26853516
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26424431
140Arginine and proline metabolism_Homo sapiens_hsa003300.25313717
141Oocyte meiosis_Homo sapiens_hsa041140.24620194

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