TMEM252

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.79097686
2angiotensin maturation (GO:0002003)6.48029713
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.21183309
4transcytosis (GO:0045056)5.56068999
5endothelium development (GO:0003158)5.38367937
6regulation of acrosome reaction (GO:0060046)5.20811405
7aminoglycoside antibiotic metabolic process (GO:0030647)5.16978491
8urate metabolic process (GO:0046415)5.04115794
9positive regulation by symbiont of host defense response (GO:0052509)4.96167118
10modulation by symbiont of host defense response (GO:0052031)4.96167118
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.96167118
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.96167118
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.96167118
14modulation by symbiont of host immune response (GO:0052553)4.96167118
15renal absorption (GO:0070293)4.85243632
16lipoprotein transport (GO:0042953)4.81333317
17glomerular filtration (GO:0003094)4.77242008
18drug transmembrane transport (GO:0006855)4.77109879
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71087966
20regulation of interferon-beta biosynthetic process (GO:0045357)4.57428618
21citrulline biosynthetic process (GO:0019240)4.54310690
22positive regulation of vasculogenesis (GO:2001214)4.46376107
23renal filtration (GO:0097205)4.42065780
24regulation of endothelial cell differentiation (GO:0045601)4.37876516
25surfactant homeostasis (GO:0043129)4.34312935
26regulation of DNA methylation (GO:0044030)4.29698307
27regulation of female gonad development (GO:2000194)4.24743103
28vascular endothelial growth factor signaling pathway (GO:0038084)4.20829432
29macrophage activation involved in immune response (GO:0002281)4.12118587
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.07874827
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06761137
32histamine transport (GO:0051608)4.06346716
33negative regulation of cell killing (GO:0031342)4.05539653
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05539653
35endothelial cell morphogenesis (GO:0001886)4.01376277
36retina vasculature morphogenesis in camera-type eye (GO:0061299)4.00669841
37detection of molecule of bacterial origin (GO:0032490)3.91820456
38positive regulation of humoral immune response (GO:0002922)3.87921103
39antigen processing and presentation of endogenous antigen (GO:0019883)3.81426271
40detection of other organism (GO:0098543)3.80630364
41drug transport (GO:0015893)3.79167992
42regulation of vasculogenesis (GO:2001212)3.76627323
43Notch signaling involved in heart development (GO:0061314)3.73024824
44regulation of bile acid biosynthetic process (GO:0070857)3.72891390
45lymphangiogenesis (GO:0001946)3.71768486
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70987777
47metanephric nephron epithelium development (GO:0072243)3.70672812
48histamine secretion (GO:0001821)3.68734125
49regulation of triglyceride catabolic process (GO:0010896)3.68432050
50adhesion of symbiont to host (GO:0044406)3.63263635
51epoxygenase P450 pathway (GO:0019373)3.60409389
52metanephric tubule development (GO:0072170)3.56834562
53metanephric nephron tubule development (GO:0072234)3.56834562
54polyol transport (GO:0015791)3.52024200
55L-amino acid import (GO:0043092)3.50262011
56detection of external biotic stimulus (GO:0098581)3.49768255
57hormone catabolic process (GO:0042447)3.49494381
58nephron epithelium development (GO:0072009)3.47415194
59immunoglobulin mediated immune response (GO:0016064)3.47096629
60metanephric epithelium development (GO:0072207)3.46322211
61neutrophil activation involved in immune response (GO:0002283)3.45691947
62chemical homeostasis within a tissue (GO:0048875)3.45028460
63cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.43639990
64fat-soluble vitamin biosynthetic process (GO:0042362)3.39957007
65DNA damage induced protein phosphorylation (GO:0006975)3.38872462
66oocyte development (GO:0048599)3.36133597
67phagocytosis, recognition (GO:0006910)3.35548113
68response to mercury ion (GO:0046689)3.35510875
69detection of bacterium (GO:0016045)3.35282649
70phosphate ion transport (GO:0006817)3.34435760
71heart trabecula formation (GO:0060347)3.32646987
72quaternary ammonium group transport (GO:0015697)3.32071547
73regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.30994385
74endocrine process (GO:0050886)3.30994385
75regulation of systemic arterial blood pressure by hormone (GO:0001990)3.30994385
76endothelial cell differentiation (GO:0045446)3.30411022
77microglial cell activation (GO:0001774)3.29631138
78endocrine hormone secretion (GO:0060986)3.29231335
79peptidyl-tyrosine autophosphorylation (GO:0038083)3.24056843
80response to host immune response (GO:0052572)3.22989064
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22989064
82nephron tubule development (GO:0072080)3.22782477
83glycine transport (GO:0015816)3.21539510
84blood vessel endothelial cell migration (GO:0043534)3.21056072
85blood vessel maturation (GO:0001955)3.19361416
86tonic smooth muscle contraction (GO:0014820)3.18783754
87cGMP-mediated signaling (GO:0019934)3.17906285
88patterning of blood vessels (GO:0001569)3.17790220
89respiratory burst (GO:0045730)3.17213158
90regulation of guanylate cyclase activity (GO:0031282)3.16340181
91multicellular organism reproduction (GO:0032504)3.15955281
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.15464132
93positive regulation of gamma-delta T cell activation (GO:0046645)3.12946439
94embryonic heart tube development (GO:0035050)3.12268129
95neutrophil activation (GO:0042119)3.11859479
96intestinal absorption (GO:0050892)3.11489749
97lysine metabolic process (GO:0006553)3.08239258
98lysine catabolic process (GO:0006554)3.08239258
99positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.07476496
100regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.07476496
101regulation of cellular extravasation (GO:0002691)3.05969415
102ovulation from ovarian follicle (GO:0001542)3.05960177
103cellular extravasation (GO:0045123)3.04931970
104endothelial tube morphogenesis (GO:0061154)3.03884424
105morphogenesis of an endothelium (GO:0003159)3.03884424
106organic cation transport (GO:0015695)3.01660126
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01354407
108response to host (GO:0075136)3.01354407
109response to host defenses (GO:0052200)3.01354407
110macrophage activation (GO:0042116)3.00385705
111cytidine deamination (GO:0009972)3.00018261
112cytidine metabolic process (GO:0046087)3.00018261
113cytidine catabolic process (GO:0006216)3.00018261
114negative regulation of cell fate specification (GO:0009996)2.99685914
115sprouting angiogenesis (GO:0002040)2.96864143
116leukocyte migration involved in inflammatory response (GO:0002523)2.95739059
117excretion (GO:0007588)2.92429218
118vasculogenesis (GO:0001570)2.92015197
119detection of biotic stimulus (GO:0009595)2.90208386
120negative regulation of endothelial cell migration (GO:0010596)2.88930950
121negative regulation of keratinocyte proliferation (GO:0010839)2.88224559
122exogenous drug catabolic process (GO:0042738)2.87224307
123negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86662517
124positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84558871
125regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.84343384
126renal tubule development (GO:0061326)2.84132509
127regulation of cardiac muscle cell contraction (GO:0086004)2.82639764
128phosphate ion transmembrane transport (GO:0035435)2.82245091
129drug catabolic process (GO:0042737)2.82116731
130regulation of systemic arterial blood pressure (GO:0003073)2.81758635
131cellular response to reactive nitrogen species (GO:1902170)2.80142961
132lung vasculature development (GO:0060426)2.79874640
133maintenance of gastrointestinal epithelium (GO:0030277)2.79837613
134protein kinase C signaling (GO:0070528)2.79179016
135negative regulation of blood vessel endothelial cell migration (GO:0043537)2.79130988
136vitamin D metabolic process (GO:0042359)2.78829960
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78520024
138sodium-independent organic anion transport (GO:0043252)2.78246993
139protein localization to cell surface (GO:0034394)2.76429993
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.75338411
141positive regulation of odontogenesis (GO:0042482)2.74953969
142response to peptidoglycan (GO:0032494)2.74837184
143leukotriene metabolic process (GO:0006691)2.74835170
144adhesion of symbiont to host cell (GO:0044650)2.74473313
145virion attachment to host cell (GO:0019062)2.74473313
146positive regulation of digestive system process (GO:0060456)2.74131428
147basement membrane organization (GO:0071711)2.73820842
148granulocyte activation (GO:0036230)2.72835055
149regulation of actin filament-based movement (GO:1903115)2.71149406
150pyrimidine ribonucleoside catabolic process (GO:0046133)2.71082519
151azole transport (GO:0045117)2.70847705
152negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69629805
153regulation of gamma-delta T cell activation (GO:0046643)2.68790495
154regulation of cellular amide metabolic process (GO:0034248)2.68555782
155citrulline metabolic process (GO:0000052)2.68514727
156drinking behavior (GO:0042756)2.68062507
157positive regulation of triglyceride lipase activity (GO:0061365)2.67978061
158positive regulation of lipoprotein lipase activity (GO:0051006)2.67978061
159venous blood vessel morphogenesis (GO:0048845)2.67933043
160production of molecular mediator involved in inflammatory response (GO:0002532)2.67867123
161negative regulation of interleukin-12 production (GO:0032695)2.67324009
162cAMP biosynthetic process (GO:0006171)2.66901678
163establishment of endothelial barrier (GO:0061028)2.66116388
164neutrophil mediated immunity (GO:0002446)2.64432981
165regulation of toll-like receptor signaling pathway (GO:0034121)2.63095696
166endothelial cell proliferation (GO:0001935)2.62718358
167regulation of B cell receptor signaling pathway (GO:0050855)2.62595193
168peptide catabolic process (GO:0043171)2.61752159
169interkinetic nuclear migration (GO:0022027)2.60866164
170mammary gland development (GO:0030879)2.59221086
171regulation of retinoic acid receptor signaling pathway (GO:0048385)2.59186251
172positive regulation of interferon-alpha production (GO:0032727)2.58891348
173I-kappaB phosphorylation (GO:0007252)2.58497217
174vitamin A metabolic process (GO:0006776)2.58377589
175regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.58349782
176phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.57976291
177vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57962158
178regulation of mast cell degranulation (GO:0043304)2.57600007
179interleukin-6-mediated signaling pathway (GO:0070102)2.55260021
180dendritic cell migration (GO:0036336)2.54586554
181dendritic cell chemotaxis (GO:0002407)2.53909490
182cell surface receptor signaling pathway involved in heart development (GO:0061311)2.53732418
183regulation of sarcomere organization (GO:0060297)2.53081033
184cellular glucuronidation (GO:0052695)2.51997493
185phosphate ion homeostasis (GO:0055062)2.51558968
186trivalent inorganic anion homeostasis (GO:0072506)2.51558968
187B cell mediated immunity (GO:0019724)2.51387647
188regulation of interferon-alpha production (GO:0032647)2.50682459
189negative regulation of epithelial cell migration (GO:0010633)2.50084944
190regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49883870
191cell migration involved in sprouting angiogenesis (GO:0002042)2.47304171
192ventricular trabecula myocardium morphogenesis (GO:0003222)2.46193444
193trabecula formation (GO:0060343)2.45427497
194renal system process (GO:0003014)2.44178555
195positive regulation of endothelial cell differentiation (GO:0045603)2.43474353
196chondrocyte proliferation (GO:0035988)2.42528151
197artery development (GO:0060840)2.41641464
198positive regulation of keratinocyte differentiation (GO:0045618)2.41621150
199cell migration involved in heart development (GO:0060973)2.40758401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62053909
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.82245430
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.64950221
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.35955600
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.23129677
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18166734
7GATA2_21666600_ChIP-Seq_HMVEC_Human2.66495088
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.49312491
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42128298
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.40478218
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.38675696
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.35391221
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30681958
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25911884
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21306553
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.15744208
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14682108
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.13471067
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05753095
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01024839
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92991805
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90182887
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87521536
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87339814
25RUNX_20019798_ChIP-Seq_JUKART_Human1.85670016
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84327257
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83018200
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.82614830
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.82378027
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76946799
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71287045
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71181662
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67847181
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.67016175
35SOX2_20726797_ChIP-Seq_SW620_Human1.63718347
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63496740
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62053660
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60808447
39CJUN_26792858_Chip-Seq_BT549_Human1.60436283
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.60288116
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59872103
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.57224508
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57016566
44CLOCK_20551151_ChIP-Seq_293T_Human1.56712778
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56215934
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53081151
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52481787
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52481787
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52393455
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50261066
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49259663
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48114234
53SPI1_23127762_ChIP-Seq_K562_Human1.47504318
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46158923
55VDR_22108803_ChIP-Seq_LS180_Human1.45019475
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44479238
57AHR_22903824_ChIP-Seq_MCF-7_Human1.44166641
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44013370
59VDR_24763502_ChIP-Seq_THP-1_Human1.42008065
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.41763538
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.41712968
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.40299179
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39938121
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37883511
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.35746006
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.35643479
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35306602
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34749701
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34650981
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.33978982
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.33978982
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31809116
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31809116
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30249894
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29711316
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29500865
77RXR_22108803_ChIP-Seq_LS180_Human1.28559579
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28351602
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.27793396
80TP53_18474530_ChIP-ChIP_U2OS_Human1.27014377
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26017109
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24506941
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24219126
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23998199
85GATA1_22025678_ChIP-Seq_K562_Human1.21623505
86GATA1_19941827_ChIP-Seq_MEL86_Mouse1.20530473
87GBX2_23144817_ChIP-Seq_PC3_Human1.19633318
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17934067
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17506121
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16682431
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16646235
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15722377
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.14974036
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14214894
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13320653
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11825122
97SCL_19346495_ChIP-Seq_HPC-7_Human1.11601589
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11457797
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.11232301
100VDR_24787735_ChIP-Seq_THP-1_Human1.11209087
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.10669617
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09790696
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09466745
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.08631603
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07979969
106TP53_16413492_ChIP-PET_HCT116_Human1.07527126
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05829865
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02637179
109BCAT_22108803_ChIP-Seq_LS180_Human1.01489738
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01205664
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00708536
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.99759907
113MYB_26560356_Chip-Seq_TH1_Human0.99494721
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.98950438
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98443025
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97609793
117MYB_26560356_Chip-Seq_TH2_Human0.96670237
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96119614
119DROSHA_22980978_ChIP-Seq_HELA_Human0.96056077
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95913351
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.95417897
122SPI1_23547873_ChIP-Seq_NB4_Human0.93366737
123SMRT_27268052_Chip-Seq_Bcells_Human0.92042250
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91774715
125GATA2_19941826_ChIP-Seq_K562_Human0.91528723
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91268205
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91268205
128RNF2_27304074_Chip-Seq_ESCs_Mouse0.91249532
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90832218
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90570429
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.90296770
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90264592
133CDX2_22108803_ChIP-Seq_LS180_Human0.89767747
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89761393
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89713759
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89413639
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88634315
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.88619933
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88053979
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88053979
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88053979
142P300_19829295_ChIP-Seq_ESCs_Human0.87917919
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87533534
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87222910
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86904661
146GATA3_27048872_Chip-Seq_THYMUS_Human0.86900418
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86307061
148KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86048645
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85964683
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.85848923
151GATA4_25053715_ChIP-Seq_YYC3_Human0.85313972
152GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85068649
153TP63_23658742_ChIP-Seq_EP156T_Human0.84953424
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84285335
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84259117
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83944930
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82382082
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81792452
159GATA3_26560356_Chip-Seq_TH2_Human0.80323499
160GATA1_19941826_ChIP-Seq_K562_Human0.79830280
161GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79626978
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79039198
163NANOG_20526341_ChIP-Seq_ESCs_Human0.78787079
164VDR_21846776_ChIP-Seq_THP-1_Human0.78407734
165GF1_26923725_Chip-Seq_HPCs_Mouse0.78125471
166GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76789121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001879_abnormal_lymphatic_vessel5.03662946
2MP0003183_abnormal_peptide_metabolism4.91587549
3MP0010368_abnormal_lymphatic_system3.84647650
4MP0005360_urolithiasis3.70750923
5MP0003724_increased_susceptibility_to3.59744511
6MP0005167_abnormal_blood-brain_barrier3.44659302
7MP0003718_maternal_effect3.39127916
8MP0006054_spinal_hemorrhage3.37634239
9MP0004272_abnormal_basement_membrane3.16558572
10MP0001666_abnormal_nutrient_absorption2.96413763
11MP0004147_increased_porphyrin_level2.83870258
12MP0003828_pulmonary_edema2.78116771
13MP0002139_abnormal_hepatobiliary_system2.76578899
14MP0009840_abnormal_foam_cell2.73245826
15MP0005377_hearing/vestibular/ear_phenot2.62338098
16MP0003878_abnormal_ear_physiology2.62338098
17MP0003303_peritoneal_inflammation2.60249524
18MP0003436_decreased_susceptibility_to2.56255959
19MP0004019_abnormal_vitamin_homeostasis2.49094566
20MP0004043_abnormal_pH_regulation2.46472804
21MP0010155_abnormal_intestine_physiology2.30045302
22MP0002138_abnormal_hepatobiliary_system2.28268988
23MP0005365_abnormal_bile_salt2.27930262
24MP0004484_altered_response_of2.27002643
25MP0001835_abnormal_antigen_presentation2.01273308
26MP0001958_emphysema2.01050052
27MP0003879_abnormal_hair_cell1.99317607
28MP0009785_altered_susceptibility_to1.94660852
29MP0000465_gastrointestinal_hemorrhage1.93539290
30MP0004084_abnormal_cardiac_muscle1.92256849
31MP0001756_abnormal_urination1.91786802
32MP0002419_abnormal_innate_immunity1.89162717
33MP0003941_abnormal_skin_development1.84645614
34MP0006138_congestive_heart_failure1.83812802
35MP0000767_abnormal_smooth_muscle1.81804808
36MP0009643_abnormal_urine_homeostasis1.80909355
37MP0005025_abnormal_response_to1.77775649
38MP0002396_abnormal_hematopoietic_system1.74046029
39MP0005171_absent_coat_pigmentation1.70133043
40MP0001664_abnormal_digestion1.68383676
41MP0004215_abnormal_myocardial_fiber1.65993736
42MP0003252_abnormal_bile_duct1.65927016
43MP0008260_abnormal_autophagy1.62293943
44MP0005503_abnormal_tendon_morphology1.62218901
45MP0002127_abnormal_cardiovascular_syste1.60008620
46MP0005395_other_phenotype1.59034823
47MP0008775_abnormal_heart_ventricle1.58541125
48MP0001765_abnormal_ion_homeostasis1.57883342
49MP0005670_abnormal_white_adipose1.56458298
50MP0005330_cardiomyopathy1.55227939
51MP0003866_abnormal_defecation1.52916687
52MP0005332_abnormal_amino_acid1.51422501
53MP0001800_abnormal_humoral_immune1.50894773
54MP0002972_abnormal_cardiac_muscle1.49628750
55MP0006082_CNS_inflammation1.49447532
56MP0009697_abnormal_copulation1.49363076
57MP0002136_abnormal_kidney_physiology1.47823078
58MP0005084_abnormal_gallbladder_morpholo1.46840849
59MP0003950_abnormal_plasma_membrane1.43557349
60MP0000230_abnormal_systemic_arterial1.42016939
61MP0004270_analgesia1.41500686
62MP0004036_abnormal_muscle_relaxation1.41290475
63MP0005451_abnormal_body_composition1.40016823
64MP0002723_abnormal_immune_serum1.39520282
65MP0005000_abnormal_immune_tolerance1.38285671
66MP0003279_aneurysm1.38086177
67MP0003567_abnormal_fetal_cardiomyocyte1.36317033
68MP0002420_abnormal_adaptive_immunity1.36221449
69MP0001790_abnormal_immune_system1.36152204
70MP0005387_immune_system_phenotype1.36152204
71MP0001544_abnormal_cardiovascular_syste1.35769801
72MP0005385_cardiovascular_system_phenoty1.35769801
73MP0005620_abnormal_muscle_contractility1.35181740
74MP0001819_abnormal_immune_cell1.35013710
75MP0001533_abnormal_skeleton_physiology1.33083932
76MP0005623_abnormal_meninges_morphology1.32907867
77MP0010329_abnormal_lipoprotein_level1.30119290
78MP0005166_decreased_susceptibility_to1.27951760
79MP0003868_abnormal_feces_composition1.27671292
80MP0002277_abnormal_respiratory_mucosa1.25932000
81MP0002452_abnormal_antigen_presenting1.25876519
82MP0005165_increased_susceptibility_to1.25490168
83MP0009379_abnormal_foot_pigmentation1.25250190
84MP0005595_abnormal_vascular_smooth1.24180644
85MP0003300_gastrointestinal_ulcer1.23882212
86MP0000343_altered_response_to1.23165265
87MP0001845_abnormal_inflammatory_respons1.21144437
88MP0000685_abnormal_immune_system1.20507255
89MP0008469_abnormal_protein_level1.18518678
90MP0000516_abnormal_urinary_system1.17891714
91MP0005367_renal/urinary_system_phenotyp1.17891714
92MP0005319_abnormal_enzyme/_coenzyme1.16280448
93MP0000249_abnormal_blood_vessel1.15816774
94MP0004883_abnormal_blood_vessel1.15477851
95MP0002148_abnormal_hypersensitivity_rea1.15156684
96MP0003763_abnormal_thymus_physiology1.14975519
97MP0010630_abnormal_cardiac_muscle1.14634702
98MP0003191_abnormal_cellular_cholesterol1.12126275
99MP0005636_abnormal_mineral_homeostasis1.07250706
100MP0000762_abnormal_tongue_morphology1.05339722
101MP0003122_maternal_imprinting1.04559948
102MP0000751_myopathy1.02888288
103MP0003045_fibrosis1.02109929
104MP0001270_distended_abdomen1.02095037
105MP0002925_abnormal_cardiovascular_devel1.02011103
106MP0002295_abnormal_pulmonary_circulatio1.00322717
107MP0005671_abnormal_response_to0.98505391
108MP0002108_abnormal_muscle_morphology0.97773420
109MP0000537_abnormal_urethra_morphology0.97324211
110MP0010234_abnormal_vibrissa_follicle0.96801262
111MP0003385_abnormal_body_wall0.95685151
112MP0005409_darkened_coat_color0.95329861
113MP0000566_synostosis0.94863219
114MP0004947_skin_inflammation0.94519038
115MP0003943_abnormal_hepatobiliary_system0.93877698
116MP0004085_abnormal_heartbeat0.93671738
117MP0002132_abnormal_respiratory_system0.93651862
118MP0000538_abnormal_urinary_bladder0.92503735
119MP0008004_abnormal_stomach_pH0.92458305
120MP0001614_abnormal_blood_vessel0.92119232
121MP0000716_abnormal_immune_system0.92074094
122MP0005164_abnormal_response_to0.91921474
123MP0002118_abnormal_lipid_homeostasis0.90673440
124MP0008877_abnormal_DNA_methylation0.90657685
125MP0003448_altered_tumor_morphology0.90092778
126MP0002128_abnormal_blood_circulation0.89779577
127MP0002896_abnormal_bone_mineralization0.89268162
128MP0000749_muscle_degeneration0.88693353
129MP0003699_abnormal_female_reproductive0.88480012
130MP0002332_abnormal_exercise_endurance0.88461601
131MP0000013_abnormal_adipose_tissue0.85000738
132MP0000015_abnormal_ear_pigmentation0.84969699
133MP0005085_abnormal_gallbladder_physiolo0.79978349
134MP0004264_abnormal_extraembryonic_tissu0.79337030
135MP0003566_abnormal_cell_adhesion0.78253830
136MP0002998_abnormal_bone_remodeling0.78188556
137MP0003806_abnormal_nucleotide_metabolis0.77366232
138MP0001784_abnormal_fluid_regulation0.77215960
139MP0000266_abnormal_heart_morphology0.76861347
140MP0000534_abnormal_ureter_morphology0.76786000
141MP0009764_decreased_sensitivity_to0.76770282
142MP0001873_stomach_inflammation0.76302941
143MP0009115_abnormal_fat_cell0.75962486
144MP0009780_abnormal_chondrocyte_physiolo0.75686526
145MP0005535_abnormal_body_temperature0.75454470
146MP0002098_abnormal_vibrissa_morphology0.74954513
147MP0001501_abnormal_sleep_pattern0.74429603
148MP0002133_abnormal_respiratory_system0.74177874
149MP0005388_respiratory_system_phenotype0.74177874
150MP0005376_homeostasis/metabolism_phenot0.74127486
151MP0001663_abnormal_digestive_system0.73219456
152MP0009278_abnormal_bone_marrow0.73090974
153MP0002398_abnormal_bone_marrow0.72469324
154MP0000490_abnormal_crypts_of0.71918841
155MP0004145_abnormal_muscle_electrophysio0.71665638
156MP0010386_abnormal_urinary_bladder0.71443001
157MP0002405_respiratory_system_inflammati0.69030592
158MP0004087_abnormal_muscle_fiber0.68504128
159MP0005248_abnormal_Harderian_gland0.68145007
160MP0005448_abnormal_energy_balance0.67776348
161MP0008961_abnormal_basal_metabolism0.67575075
162MP0004381_abnormal_hair_follicle0.67440528
163MP0002928_abnormal_bile_duct0.67239538
164MP0005187_abnormal_penis_morphology0.64614718
165MP0002722_abnormal_immune_system0.63461748
166MP0008874_decreased_physiological_sensi0.61799835
167MP0003075_altered_response_to0.61693547
168MP0005334_abnormal_fat_pad0.60163545
169MP0000609_abnormal_liver_physiology0.60125410
170MP0000678_abnormal_parathyroid_gland0.58727509

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.24945694
2Hyperactive renin-angiotensin system (HP:0000841)5.88519555
3Increased circulating renin level (HP:0000848)5.71500194
4Hypokalemic alkalosis (HP:0001949)5.34450064
5Eczematoid dermatitis (HP:0000976)5.27455029
6Abnormality of chloride homeostasis (HP:0011422)5.12819713
7Orchitis (HP:0100796)4.77616801
8Polyuria (HP:0000103)4.77102406
9Hypomagnesemia (HP:0002917)4.75322500
10Abnormal urine output (HP:0012590)4.62068642
11Myositis (HP:0100614)4.57066397
12Abnormality of renal excretion (HP:0011036)4.43183435
13Retrobulbar optic neuritis (HP:0100654)4.37637017
14Optic neuritis (HP:0100653)4.37637017
15Abnormality of renin-angiotensin system (HP:0000847)4.13154954
16Polydipsia (HP:0001959)4.10177070
17Abnormal drinking behavior (HP:0030082)4.10177070
18Abnormality of magnesium homeostasis (HP:0004921)4.04154216
19Proximal tubulopathy (HP:0000114)4.03890748
20Recurrent abscess formation (HP:0002722)3.96869296
21Hyperaldosteronism (HP:0000859)3.92998604
22Tetany (HP:0001281)3.91885911
23Abnormality of macrophages (HP:0004311)3.83121825
24Recurrent bacterial skin infections (HP:0005406)3.82285069
25Chronic diarrhea (HP:0002028)3.75612203
26Gingivitis (HP:0000230)3.66082319
27Gout (HP:0001997)3.63286114
28Aortic aneurysm (HP:0004942)3.46552032
29Osteomalacia (HP:0002749)3.45447240
30Recurrent gram-negative bacterial infections (HP:0005420)3.42097262
31Alkalosis (HP:0001948)3.39387150
32Lymphangioma (HP:0100764)3.35717836
33Gastrointestinal infarctions (HP:0005244)3.33346565
34Fat malabsorption (HP:0002630)3.32929827
35Congenital sensorineural hearing impairment (HP:0008527)3.24117383
36Hyperuricemia (HP:0002149)3.20992964
37Increased purine levels (HP:0004368)3.20992964
38Keratoconjunctivitis sicca (HP:0001097)3.19966017
39Hypokalemia (HP:0002900)3.15851650
40Distal lower limb muscle weakness (HP:0009053)3.14756919
41Stomatitis (HP:0010280)3.13556864
42Hypobetalipoproteinemia (HP:0003563)3.08934060
43Facial diplegia (HP:0001349)3.08051475
44Encephalitis (HP:0002383)3.06378470
45Renal salt wasting (HP:0000127)3.05883709
46Abnormality of the vitamin B12 metabolism (HP:0004341)2.97080419
47Acanthocytosis (HP:0001927)2.94811029
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93900242
49Abnormality of purine metabolism (HP:0004352)2.87407135
50Keratoconjunctivitis (HP:0001096)2.86562749
51Muscle fiber splitting (HP:0003555)2.84455433
52Hypophosphatemic rickets (HP:0004912)2.80676086
53Hypercalciuria (HP:0002150)2.78717282
54Hyperglycinuria (HP:0003108)2.76530200
55Abnormality of potassium homeostasis (HP:0011042)2.75526601
56Enlarged epiphyses (HP:0010580)2.73574680
57Papillary thyroid carcinoma (HP:0002895)2.72562709
58Pigmentary retinal degeneration (HP:0001146)2.70803812
59Abnormality of vitamin B metabolism (HP:0004340)2.70034772
60Esophageal varix (HP:0002040)2.68904019
61Generalized aminoaciduria (HP:0002909)2.68045757
62Absent eyebrow (HP:0002223)2.67784578
63Elevated erythrocyte sedimentation rate (HP:0003565)2.65386285
64Recurrent fungal infections (HP:0002841)2.54223462
65Thin bony cortex (HP:0002753)2.51038313
66Impulsivity (HP:0100710)2.50377640
67Vasculitis (HP:0002633)2.49872297
68Hemoptysis (HP:0002105)2.48677536
69Widely patent fontanelles and sutures (HP:0004492)2.48323479
70Peritonitis (HP:0002586)2.46395474
71Aortic dissection (HP:0002647)2.44816299
72Abnormality of urine glucose concentration (HP:0011016)2.41643448
73Glycosuria (HP:0003076)2.41643448
74Renal tubular acidosis (HP:0001947)2.40953265
75Hematochezia (HP:0002573)2.40509200
76Polycythemia (HP:0001901)2.39412644
77Meningitis (HP:0001287)2.38536459
78Ketoacidosis (HP:0001993)2.37699161
79Steatorrhea (HP:0002570)2.37486276
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36580653
81Abnormality of proline metabolism (HP:0010907)2.36421946
82Hydroxyprolinuria (HP:0003080)2.36421946
83Ventricular fibrillation (HP:0001663)2.36246276
84Hypoplasia of the iris (HP:0007676)2.34698204
85Hypophosphatemia (HP:0002148)2.32959008
86Increased connective tissue (HP:0009025)2.30187028
87Atrial fibrillation (HP:0005110)2.29786450
88Potter facies (HP:0002009)2.29497865
89Facial shape deformation (HP:0011334)2.29497865
90Amyloidosis (HP:0011034)2.28950764
91Osteomyelitis (HP:0002754)2.28822988
92Generalized muscle weakness (HP:0003324)2.25824915
93Confusion (HP:0001289)2.24886534
94Aplasia of the musculature (HP:0100854)2.23751408
95Vascular calcification (HP:0004934)2.23158125
96Abnormality of alkaline phosphatase activity (HP:0004379)2.22539798
97Autoimmune thrombocytopenia (HP:0001973)2.21432506
98Abnormal enzyme/coenzyme activity (HP:0012379)2.20835392
99Chest pain (HP:0100749)2.20376308
100Absent hand (HP:0004050)2.20229740
101Recurrent skin infections (HP:0001581)2.20092521
102Ileus (HP:0002595)2.20009534
103Sudden death (HP:0001699)2.18940816
104Decreased circulating renin level (HP:0003351)2.18542268
105Abnormality of the costochondral junction (HP:0000919)2.17960535
106Aplasia cutis congenita (HP:0001057)2.17643551
107Colitis (HP:0002583)2.17172541
108Abnormality of monocarboxylic acid metabolism (HP:0010996)2.16897990
109Urticaria (HP:0001025)2.16873715
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14778073
111Nausea (HP:0002018)2.14631760
112Mediastinal lymphadenopathy (HP:0100721)2.13372736
113Vascular tortuosity (HP:0004948)2.12965784
114Loss of speech (HP:0002371)2.11812459
115Ventricular tachycardia (HP:0004756)2.11024710
116Cardiovascular calcification (HP:0011915)2.10715674
117Abnormality of the calf musculature (HP:0001430)2.08246733
118Abnormal delayed hypersensitivity skin test (HP:0002963)2.06710592
119Elevated alkaline phosphatase (HP:0003155)2.04906281
120Pulmonary infiltrates (HP:0002113)2.02798754
121Subacute progressive viral hepatitis (HP:0006572)2.02672702
122Posterior subcapsular cataract (HP:0007787)2.02217698
123Segmental peripheral demyelination/remyelination (HP:0003481)2.02104734
124Chondrocalcinosis (HP:0000934)2.01033541
125Primary atrial arrhythmia (HP:0001692)2.00971744
126Abnormality of vitamin metabolism (HP:0100508)2.00460584
127Obstructive lung disease (HP:0006536)1.99073299
128Chronic obstructive pulmonary disease (HP:0006510)1.99073299
129Portal hypertension (HP:0001409)1.98246208
130Nonimmune hydrops fetalis (HP:0001790)1.97852521
131Hip contracture (HP:0003273)1.97277967
132Absent eyelashes (HP:0000561)1.97147643
133Dehydration (HP:0001944)1.96648313
134Adactyly (HP:0009776)1.96467288
135Supraventricular arrhythmia (HP:0005115)1.96037210
136Anorexia (HP:0002039)1.95903120
137Abnormality of Sharpey fibers (HP:0100685)1.95494738
138Abnormality of fatty-acid metabolism (HP:0004359)1.95442776
139Right ventricular cardiomyopathy (HP:0011663)1.95309942
140Cheilitis (HP:0100825)1.94896536
141Difficulty running (HP:0009046)1.94874639
142Pulmonary artery stenosis (HP:0004415)1.94712535
143Diaphragmatic weakness (HP:0009113)1.93388278
144Cellulitis (HP:0100658)1.93017728
145Increased IgE level (HP:0003212)1.91588600
146Wide cranial sutures (HP:0010537)1.90899187
147Episodic fever (HP:0001954)1.90783652
148Enlarged kidneys (HP:0000105)1.90025182
149Neonatal death (HP:0003811)1.89460040
150Arterial thrombosis (HP:0004420)1.89397293
151Mesangial abnormality (HP:0001966)1.89144070
152Abnormality of glycine metabolism (HP:0010895)1.89035606
153Abnormality of serine family amino acid metabolism (HP:0010894)1.89035606
154Shawl scrotum (HP:0000049)1.88765314
155Pulmonary embolism (HP:0002204)1.88401734
156Prolonged QT interval (HP:0001657)1.88221758
157Skin rash (HP:0000988)1.87908690
158Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86331344
159Systemic lupus erythematosus (HP:0002725)1.85720042
160Subcapsular cataract (HP:0000523)1.84455010
161Supraventricular tachycardia (HP:0004755)1.83301623
162Rickets (HP:0002748)1.83182572
163Inflammation of the large intestine (HP:0002037)1.81865536
164Exercise-induced muscle cramps (HP:0003710)1.81478820
165Abnormality of the endocardium (HP:0004306)1.81192353
166Abnormal urine phosphate concentration (HP:0012599)1.80978762
167Hypoglycemic coma (HP:0001325)1.79128142
168Spontaneous hematomas (HP:0007420)1.78896708
169Aplasia/Hypoplasia of the fovea (HP:0008060)1.78661885
170Hypoplasia of the fovea (HP:0007750)1.78661885
171Malnutrition (HP:0004395)1.78180022
172Toxemia of pregnancy (HP:0100603)1.77405819
173Nephrolithiasis (HP:0000787)1.75639739
174Pancreatitis (HP:0001733)1.75324165
175Abnormality of the hepatic vasculature (HP:0006707)1.74710333
176Lipoatrophy (HP:0100578)1.74097502
177Acne (HP:0001061)1.73508795
178Alopecia of scalp (HP:0002293)1.71995438
179Metaphyseal irregularity (HP:0003025)1.71518384
180Visceral angiomatosis (HP:0100761)1.70446024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.35736939
2KDR4.19210301
3PDK23.98883918
4WNK43.72837376
5MYLK3.58946278
6ACVR1B3.54093972
7MAP2K63.42234188
8RIPK43.26838858
9OXSR12.86995487
10AKT32.86568261
11TGFBR22.77726415
12WNK32.73375074
13MAP3K52.71573917
14TAOK32.43624213
15EPHB22.23946679
16INSRR2.08768554
17STK392.08340187
18RIPK12.07157288
19TYK22.02285214
20MAP3K131.98610494
21SIK21.90850458
22TGFBR11.84360049
23KSR21.83003524
24FER1.79570449
25TLK11.77333580
26NUAK11.60613922
27STK38L1.54246066
28BLK1.52122883
29PTK2B1.51560939
30MAP3K31.46106642
31SIK31.42965501
32MAP3K141.36849439
33FRK1.36001213
34DMPK1.30036485
35MAP4K11.28213586
36NEK61.28202294
37TTN1.23622602
38GRK11.22903668
39MELK1.20910211
40TNK21.19642089
41MAPK121.18107689
42GRK61.16703388
43ZAK1.16303179
44STK241.15791537
45MAP3K21.15443548
46PTK61.13551314
47LATS11.13276314
48ZAP701.10922934
49IRAK11.09373264
50MAP3K81.08831265
51JAK21.08543546
52BCKDK1.05992227
53MAP3K11.05941126
54TAOK11.01862234
55JAK11.01861887
56LMTK20.97825431
57DDR20.95463402
58WNK10.95369620
59MAPK150.94588159
60PIM10.94103064
61JAK30.93822893
62HCK0.93535625
63PDK10.92711198
64OBSCN0.92478545
65RAF10.91827847
66MAP3K90.90528557
67MAPK70.88733731
68YES10.85075381
69FES0.84744054
70MATK0.84581331
71IRAK30.83726672
72ARAF0.83535365
73BMPR1B0.81918085
74SGK2230.81727982
75SGK4940.81727982
76MARK20.81033802
77RET0.78739611
78PIK3CA0.76607406
79MAP3K70.76032574
80MARK30.75131329
81PRKCZ0.74440411
82GSK3A0.74359965
83NLK0.72929170
84SGK20.72125323
85EPHB10.72096265
86BTK0.70754107
87MST40.70258030
88KSR10.70190334
89SIK10.70125694
90PAK40.69945621
91BCR0.68975875
92FGR0.67816724
93MAP3K60.67354810
94EPHA30.66661139
95IRAK20.66261221
96PRKG20.66101163
97PRKAA20.64503646
98TXK0.64433955
99ERN10.63621054
100CDK80.63367943
101EPHA20.63074841
102SYK0.62859719
103LYN0.61888959
104PDK40.61104518
105PDK30.61104518
106MAP3K110.58999243
107TESK20.55943152
108MST1R0.55765180
109CDK190.55191138
110BMPR20.52307013
111PAK20.51752768
112MAP2K20.51326320
113PRPF4B0.51170439
114LCK0.49027726
115MOS0.47450649
116SGK30.46065743
117CDK120.45590632
118TRPM70.45041003
119TNIK0.44823861
120PRKCH0.43855697
121MAPKAPK30.43520315
122PTK20.43354472
123TBK10.43274350
124STK110.43136225
125NEK90.41130550
126MET0.39631405
127TSSK60.39283626
128CAMK40.39208634
129IGF1R0.39195499
130FGFR40.38572408
131CSF1R0.38449402
132PRKCE0.38118632
133PRKD10.38022577
134IRAK40.37735312
135LRRK20.37668932
136FYN0.36966519
137ROCK10.35977167
138MAP2K40.34883475
139KIT0.34838302
140MAP2K10.33261479
141IKBKE0.32772699
142PRKAA10.32410660
143TAOK20.32349375
144MAP2K30.31706239
145CAMK10.31000527
146TEC0.30796830
147PDGFRA0.30399392
148PHKG20.30136832
149PHKG10.30136832
150STK30.29257328
151MAP3K120.29239210
152LATS20.29086332
153PAK30.29030154
154PIK3CG0.27977459
155INSR0.27324741
156ERBB20.27243172
157SGK10.26401783
158CSK0.25641020
159AKT20.24213869
160CDC42BPA0.23951244
161PDPK10.23918525
162FGFR30.22550857
163CDK90.21903098

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.45709913
2Caffeine metabolism_Homo sapiens_hsa002322.60355333
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50033479
4Propanoate metabolism_Homo sapiens_hsa006402.39522457
5Protein digestion and absorption_Homo sapiens_hsa049742.12048976
6Carbohydrate digestion and absorption_Homo sapiens_hsa049732.08455755
7Mineral absorption_Homo sapiens_hsa049782.04041401
8Bile secretion_Homo sapiens_hsa049762.02281273
9Fatty acid degradation_Homo sapiens_hsa000712.02020251
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00752562
11Adherens junction_Homo sapiens_hsa045201.95716350
12Osteoclast differentiation_Homo sapiens_hsa043801.93044838
13Histidine metabolism_Homo sapiens_hsa003401.86189078
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81191622
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.80690505
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80501158
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.77015552
18Dilated cardiomyopathy_Homo sapiens_hsa054141.69271684
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.65159197
20Leishmaniasis_Homo sapiens_hsa051401.62289015
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.62053909
22Focal adhesion_Homo sapiens_hsa045101.61441772
23ECM-receptor interaction_Homo sapiens_hsa045121.61419447
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59815487
25Staphylococcus aureus infection_Homo sapiens_hsa051501.59654723
26Butanoate metabolism_Homo sapiens_hsa006501.53494514
27Renin-angiotensin system_Homo sapiens_hsa046141.47041528
28PPAR signaling pathway_Homo sapiens_hsa033201.46435065
29Tight junction_Homo sapiens_hsa045301.45975269
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44313499
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42737113
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41975190
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39611219
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38204559
35Peroxisome_Homo sapiens_hsa041461.36640436
36Tryptophan metabolism_Homo sapiens_hsa003801.35477496
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33395417
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.32714547
39Sulfur metabolism_Homo sapiens_hsa009201.30306503
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.27905227
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27213750
42Linoleic acid metabolism_Homo sapiens_hsa005911.25161976
43Dorso-ventral axis formation_Homo sapiens_hsa043201.23866223
44Galactose metabolism_Homo sapiens_hsa000521.22346461
45Cardiac muscle contraction_Homo sapiens_hsa042601.19926984
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18381145
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17634646
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17345847
49Arginine and proline metabolism_Homo sapiens_hsa003301.16546414
50Retinol metabolism_Homo sapiens_hsa008301.13294890
51beta-Alanine metabolism_Homo sapiens_hsa004101.13120215
52Tuberculosis_Homo sapiens_hsa051521.11799371
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10034224
54Influenza A_Homo sapiens_hsa051641.08805746
55Fatty acid metabolism_Homo sapiens_hsa012121.07827798
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05186617
57Chemical carcinogenesis_Homo sapiens_hsa052041.05184967
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04083307
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03480908
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03249658
61Lysine degradation_Homo sapiens_hsa003101.02681324
62Chemokine signaling pathway_Homo sapiens_hsa040621.01351282
63Malaria_Homo sapiens_hsa051441.01309035
64B cell receptor signaling pathway_Homo sapiens_hsa046621.01276300
65Notch signaling pathway_Homo sapiens_hsa043301.00925387
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99463262
67Rap1 signaling pathway_Homo sapiens_hsa040150.99158605
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96181220
69Pyruvate metabolism_Homo sapiens_hsa006200.94593842
70Ovarian steroidogenesis_Homo sapiens_hsa049130.92768345
71Acute myeloid leukemia_Homo sapiens_hsa052210.90185972
72Basal cell carcinoma_Homo sapiens_hsa052170.87289104
73Gastric acid secretion_Homo sapiens_hsa049710.86485112
74Other glycan degradation_Homo sapiens_hsa005110.85967539
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85858582
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85638374
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85404933
78GnRH signaling pathway_Homo sapiens_hsa049120.84857255
79Starch and sucrose metabolism_Homo sapiens_hsa005000.84120819
80Allograft rejection_Homo sapiens_hsa053300.83995718
81Fatty acid biosynthesis_Homo sapiens_hsa000610.83742658
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83510123
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.83130169
84Collecting duct acid secretion_Homo sapiens_hsa049660.83002459
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82831250
86Hippo signaling pathway_Homo sapiens_hsa043900.81762575
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80526122
88Insulin resistance_Homo sapiens_hsa049310.79306133
89Thyroid hormone synthesis_Homo sapiens_hsa049180.78079755
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77982738
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76990956
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.75982675
93Graft-versus-host disease_Homo sapiens_hsa053320.75876145
94Proteoglycans in cancer_Homo sapiens_hsa052050.75843000
95Autoimmune thyroid disease_Homo sapiens_hsa053200.73990836
96HIF-1 signaling pathway_Homo sapiens_hsa040660.73420135
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71719925
98Measles_Homo sapiens_hsa051620.71257214
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70975940
100TGF-beta signaling pathway_Homo sapiens_hsa043500.70682576
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70495282
102Sphingolipid metabolism_Homo sapiens_hsa006000.68613829
103Phagosome_Homo sapiens_hsa041450.66057219
104African trypanosomiasis_Homo sapiens_hsa051430.65194564
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65081609
106Hepatitis C_Homo sapiens_hsa051600.64840854
107Small cell lung cancer_Homo sapiens_hsa052220.61420665
108Oxidative phosphorylation_Homo sapiens_hsa001900.61410516
109Inositol phosphate metabolism_Homo sapiens_hsa005620.61259774
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61235055
111Non-small cell lung cancer_Homo sapiens_hsa052230.61087557
112Arginine biosynthesis_Homo sapiens_hsa002200.60427403
113T cell receptor signaling pathway_Homo sapiens_hsa046600.60378748
114Fat digestion and absorption_Homo sapiens_hsa049750.60075376
115Phenylalanine metabolism_Homo sapiens_hsa003600.59891685
116Glutathione metabolism_Homo sapiens_hsa004800.59731047
117Renin secretion_Homo sapiens_hsa049240.59222364
118Prostate cancer_Homo sapiens_hsa052150.58777865
119Prolactin signaling pathway_Homo sapiens_hsa049170.58097013
120Axon guidance_Homo sapiens_hsa043600.57869747
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57859728
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57624801
123Hepatitis B_Homo sapiens_hsa051610.57097866
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.56875911
125TNF signaling pathway_Homo sapiens_hsa046680.56072717
126Melanogenesis_Homo sapiens_hsa049160.55958230
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.55837875
128Arachidonic acid metabolism_Homo sapiens_hsa005900.54554076
129Herpes simplex infection_Homo sapiens_hsa051680.54348244
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.53795053
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53460035
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52115515
133Hematopoietic cell lineage_Homo sapiens_hsa046400.51737163
134ABC transporters_Homo sapiens_hsa020100.51535148
135Carbon metabolism_Homo sapiens_hsa012000.51381470
136Gap junction_Homo sapiens_hsa045400.50488867
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.50289947
138FoxO signaling pathway_Homo sapiens_hsa040680.50028159
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.49807248
140Pancreatic secretion_Homo sapiens_hsa049720.49643803
141Pathways in cancer_Homo sapiens_hsa052000.48931563
142Endometrial cancer_Homo sapiens_hsa052130.48503391
143Renal cell carcinoma_Homo sapiens_hsa052110.48418432
144Ether lipid metabolism_Homo sapiens_hsa005650.48076037
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47702886
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46343485
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.45991421
148Platelet activation_Homo sapiens_hsa046110.45689804
149Parkinsons disease_Homo sapiens_hsa050120.45496324
150Ras signaling pathway_Homo sapiens_hsa040140.45083941
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.44972416
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44549300
153Viral myocarditis_Homo sapiens_hsa054160.44275964
154Rheumatoid arthritis_Homo sapiens_hsa053230.43788352
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43409465
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42830496
157Toxoplasmosis_Homo sapiens_hsa051450.41220496
158Glycerolipid metabolism_Homo sapiens_hsa005610.40888296
159Fructose and mannose metabolism_Homo sapiens_hsa000510.40066457
160Cocaine addiction_Homo sapiens_hsa050300.39490274
161Amoebiasis_Homo sapiens_hsa051460.39475581
162Pertussis_Homo sapiens_hsa051330.39199538
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39111575
164Choline metabolism in cancer_Homo sapiens_hsa052310.38610364
165mTOR signaling pathway_Homo sapiens_hsa041500.35974732

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