ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intestinal absorption (GO:0050892)	9.45180429
2	intestinal cholesterol absorption (GO:0030299)	9.34526991
3	regulation of guanylate cyclase activity (GO:0031282)	7.67754600
4	angiotensin maturation (GO:0002003)	7.19338879
5	fat-soluble vitamin biosynthetic process (GO:0042362)	6.43284491
6	epoxygenase P450 pathway (GO:0019373)	6.37872917
7	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.74793688
8	positive regulation of guanylate cyclase activity (GO:0031284)	5.70947745
9	intestinal epithelial cell development (GO:0060576)	5.58525182
10	vitamin A metabolic process (GO:0006776)	5.52873729
11	flavonoid metabolic process (GO:0009812)	5.52369468
12	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	5.23716379
13	endocrine process (GO:0050886)	5.23716379
14	regulation of systemic arterial blood pressure by hormone (GO:0001990)	5.23716379
15	regulation of bile acid biosynthetic process (GO:0070857)	5.12408932
16	plasma lipoprotein particle assembly (GO:0034377)	5.09746467
17	regulation of triglyceride catabolic process (GO:0010896)	5.01304935
18	positive regulation of lipoprotein lipase activity (GO:0051006)	5.00880585
19	positive regulation of triglyceride lipase activity (GO:0061365)	5.00880585
20	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.99457922
21	phospholipid efflux (GO:0033700)	4.93466127
22	lipoprotein metabolic process (GO:0042157)	4.88616968
23	regulation of cholesterol esterification (GO:0010872)	4.84719330
24	regulation of systemic arterial blood pressure (GO:0003073)	4.83079018
25	protein-lipid complex assembly (GO:0065005)	4.72568197
26	regulation of cellular extravasation (GO:0002691)	4.71126057
27	actin filament depolymerization (GO:0030042)	4.69858055
28	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.67889347
29	regulation of cGMP biosynthetic process (GO:0030826)	4.66450078
30	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.63870415
31	regulation of cholesterol homeostasis (GO:2000188)	4.63239335
32	modified amino acid transport (GO:0072337)	4.61828611
33	very-low-density lipoprotein particle assembly (GO:0034379)	4.55482609
34	drug catabolic process (GO:0042737)	4.44509156
35	protein-lipid complex remodeling (GO:0034368)	4.39230873
36	macromolecular complex remodeling (GO:0034367)	4.39230873
37	plasma lipoprotein particle remodeling (GO:0034369)	4.39230873
38	antibacterial humoral response (GO:0019731)	4.36702566
39	bile acid and bile salt transport (GO:0015721)	4.33049660
40	cholesterol efflux (GO:0033344)	4.32826233
41	renal system process involved in regulation of blood volume (GO:0001977)	4.28200020
42	alkaloid metabolic process (GO:0009820)	4.26558011
43	antimicrobial humoral response (GO:0019730)	4.24245184
44	lipoprotein transport (GO:0042953)	4.17363512
45	negative regulation of sterol transport (GO:0032372)	4.17362151
46	negative regulation of cholesterol transport (GO:0032375)	4.17362151
47	reverse cholesterol transport (GO:0043691)	4.14955474
48	digestive system process (GO:0022600)	4.14059820
49	glucose 6-phosphate metabolic process (GO:0051156)	4.06470055
50	cholesterol homeostasis (GO:0042632)	4.01962517
51	sterol homeostasis (GO:0055092)	3.99507097
52	plasma lipoprotein particle organization (GO:0071827)	3.96948879
53	glutamine family amino acid biosynthetic process (GO:0009084)	3.96025673
54	vitamin transmembrane transport (GO:0035461)	3.94870302
55	positive regulation of pseudopodium assembly (GO:0031274)	3.92277016
56	L-ascorbic acid metabolic process (GO:0019852)	3.91252176
57	cellular response to nitric oxide (GO:0071732)	3.88770005
58	regulation of cGMP metabolic process (GO:0030823)	3.88564981
59	urea metabolic process (GO:0019627)	3.87014165
60	urea cycle (GO:0000050)	3.87014165
61	protein-lipid complex subunit organization (GO:0071825)	3.82638761
62	maintenance of gastrointestinal epithelium (GO:0030277)	3.81984104
63	cytidine deamination (GO:0009972)	3.81786078
64	cytidine metabolic process (GO:0046087)	3.81786078
65	cytidine catabolic process (GO:0006216)	3.81786078
66	hormone catabolic process (GO:0042447)	3.80308529
67	positive regulation of triglyceride metabolic process (GO:0090208)	3.77483167
68	midgut development (GO:0007494)	3.77032776
69	glycolipid catabolic process (GO:0019377)	3.76210866
70	regulation of vitamin metabolic process (GO:0030656)	3.74872339
71	nucleoside diphosphate biosynthetic process (GO:0009133)	3.74661375
72	low-density lipoprotein particle remodeling (GO:0034374)	3.74609632
73	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.74172822
74	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.74172822
75	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.73541911
76	glycosphingolipid catabolic process (GO:0046479)	3.71108344
77	high-density lipoprotein particle remodeling (GO:0034375)	3.67300919
78	vitamin transport (GO:0051180)	3.66455171
79	diacylglycerol metabolic process (GO:0046339)	3.65739852
80	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.63243054
81	sterol transport (GO:0015918)	3.62662622
82	cholesterol transport (GO:0030301)	3.62662622
83	fat-soluble vitamin metabolic process (GO:0006775)	3.60355641
84	arginine metabolic process (GO:0006525)	3.52110861
85	virion attachment to host cell (GO:0019062)	3.51627220
86	adhesion of symbiont to host cell (GO:0044650)	3.51627220
87	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.51052868
88	fructose metabolic process (GO:0006000)	3.49007308
89	cGMP-mediated signaling (GO:0019934)	3.48350443
90	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.48093570
91	regulation of pseudopodium assembly (GO:0031272)	3.47593590
92	peptide catabolic process (GO:0043171)	3.47294446
93	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.47244084
94	vitamin biosynthetic process (GO:0009110)	3.44413799
95	cellular carbohydrate catabolic process (GO:0044275)	3.41728172
96	NADH metabolic process (GO:0006734)	3.38922687
97	nitrogen cycle metabolic process (GO:0071941)	3.38472312
98	triglyceride homeostasis (GO:0070328)	3.37355314
99	acylglycerol homeostasis (GO:0055090)	3.37355314
100	response to nitric oxide (GO:0071731)	3.37299929
101	bile acid metabolic process (GO:0008206)	3.32047813
102	cellular glucuronidation (GO:0052695)	3.31808898
103	positive regulation of cGMP biosynthetic process (GO:0030828)	3.29440082
104	positive regulation of glycoprotein metabolic process (GO:1903020)	3.29422530
105	phospholipid homeostasis (GO:0055091)	3.25533072
106	homocysteine metabolic process (GO:0050667)	3.24322290
107	cellular response to reactive nitrogen species (GO:1902170)	3.23889022
108	cysteine metabolic process (GO:0006534)	3.23045779
109	drinking behavior (GO:0042756)	3.22842298
110	phenylpropanoid metabolic process (GO:0009698)	3.19873843
111	sulfation (GO:0051923)	3.18734016
112	peptide hormone processing (GO:0016486)	3.13534340
113	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.11735701
114	lipid homeostasis (GO:0055088)	3.11576937
115	sphingomyelin metabolic process (GO:0006684)	3.11141864
116	glycosylceramide metabolic process (GO:0006677)	3.10878232
117	serine family amino acid biosynthetic process (GO:0009070)	3.09835779
118	leukotriene metabolic process (GO:0006691)	3.09611364
119	quinone biosynthetic process (GO:1901663)	3.03410603
120	pyrimidine nucleoside catabolic process (GO:0046135)	3.02332679
121	drug transport (GO:0015893)	3.02033494
122	epithelial structure maintenance (GO:0010669)	3.01791859
123	cobalamin metabolic process (GO:0009235)	3.00660104
124	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.00550825
125	response to hepatocyte growth factor (GO:0035728)	3.00255470
126	cellular response to hepatocyte growth factor stimulus (GO:0035729)	3.00255470
127	cGMP biosynthetic process (GO:0006182)	2.99632068
128	positive regulation of lipid catabolic process (GO:0050996)	2.98987732
129	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.96985050
130	regulation of triglyceride metabolic process (GO:0090207)	2.96984502
131	digestion (GO:0007586)	2.95245685
132	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.94595597
133	L-alpha-amino acid transmembrane transport (GO:1902475)	2.93678145
134	drug metabolic process (GO:0017144)	2.93055894
135	respiratory tube development (GO:0030323)	2.92852067
136	mucosal immune response (GO:0002385)	2.92634056
137	folic acid metabolic process (GO:0046655)	2.90128818
138	folic acid-containing compound biosynthetic process (GO:0009396)	2.89910952
139	adhesion of symbiont to host (GO:0044406)	2.89471313
140	thyroid hormone metabolic process (GO:0042403)	2.89457886
141	sulfur compound transport (GO:0072348)	2.84622678
142	trophectodermal cell differentiation (GO:0001829)	2.84235936
143	plasma lipoprotein particle clearance (GO:0034381)	2.83034112
144	sulfur amino acid catabolic process (GO:0000098)	2.81238594
145	transepithelial transport (GO:0070633)	2.79804508
146	uronic acid metabolic process (GO:0006063)	2.78863836
147	glucuronate metabolic process (GO:0019585)	2.78863836
148	oligosaccharide catabolic process (GO:0009313)	2.78513385
149	regulation of sterol transport (GO:0032371)	2.73175751
150	regulation of cholesterol transport (GO:0032374)	2.73175751

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.60320113
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.25801023
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.73303144
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.93881485
5	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.87945897
6	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.54421785
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.24181555
8	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.17217376
9	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.03133412
10	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.82724764
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.66845226
12	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.65382750
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.56610634
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.48211600
15	GATA6_25053715_ChIP-Seq_YYC3_Human	2.40290145
16	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	2.38353015
17	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.30567055
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.29246567
19	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.26903683
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.25440228
21	GATA4_25053715_ChIP-Seq_YYC3_Human	2.22371383
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.21441015
23	AR_21909140_ChIP-Seq_LNCAP_Human	2.02244127
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.02036460
25	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.01592777
26	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.91744022
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.89264747
28	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.88805296
29	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.80320372
30	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.79413552
31	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.75688388
32	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.74232581
33	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.67621344
34	SA1_27219007_Chip-Seq_Bcells_Human	1.64321200
35	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.62386688
36	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.61971638
37	CTCF_27219007_Chip-Seq_Bcells_Human	1.60660073
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.59528749
39	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.58036558
40	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.53842904
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.51384693
42	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.49752835
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.48813391
44	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.48140828
45	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.48129160
46	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.47552183
47	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.46945161
48	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.45969089
49	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45595967
50	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.45477565
51	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.44012777
52	ATF3_27146783_Chip-Seq_COLON_Human	1.43553108
53	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.42713406
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.42604019
55	SOX2_20726797_ChIP-Seq_SW620_Human	1.42067890
56	GATA1_22025678_ChIP-Seq_K562_Human	1.39833873
57	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.39042677
58	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38222819
59	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.36474690
60	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35352671
61	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.34550365
62	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.34514919
63	RACK7_27058665_Chip-Seq_MCF-7_Human	1.34446972
64	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.33514154
65	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.30116346
66	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.29030167
67	CLOCK_20551151_ChIP-Seq_293T_Human	1.25936108
68	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.25742111
69	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.25607103
70	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.23922350
71	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.23410796
72	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.22683593
73	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.20436125
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19428811
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17409803
76	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.14495387
77	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13484043
78	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.13387280
79	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12915775
80	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.12734965
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.12649084
82	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.12418509
83	CTCF_20526341_ChIP-Seq_ESCs_Human	1.11478426
84	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.10862008
85	ZNF263_19887448_ChIP-Seq_K562_Human	1.10131259
86	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.09643250
87	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.09539081
88	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06905164
89	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.05612514
90	P68_20966046_ChIP-Seq_HELA_Human	1.05422862
91	E2F1_20622854_ChIP-Seq_HELA_Human	1.05270188
92	EGR1_19032775_ChIP-ChIP_M12_Human	1.04799754
93	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.04645500
94	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.04390898
95	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04208208
96	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02755669
97	LXR_22292898_ChIP-Seq_THP-1_Human	1.02273507
98	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.02067745
99	KLF5_25053715_ChIP-Seq_YYC3_Human	1.01170989
100	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.01067934
101	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.01052273
102	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.00423813
103	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.00286426
104	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.99991259
105	KAP1_27257070_Chip-Seq_ESCs_Mouse	0.99396222
106	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.98831394
107	TP63_22573176_ChIP-Seq_HFKS_Human	0.98288945
108	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98141403
109	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.98058393
110	STAT1_20625510_ChIP-Seq_HELA_Human	0.97939130
111	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.97846392
112	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.97800172
113	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.96708410
114	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.96626113
115	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.96483521
116	VDR_21846776_ChIP-Seq_THP-1_Human	0.96457741
117	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96085338
118	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95776163
119	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95163586
120	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.94647466
121	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93727939
122	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.92489052
123	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.91917265
124	PHF8_20622854_ChIP-Seq_HELA_Human	0.91898120
125	CREB1_26743006_Chip-Seq_LNCaP_Human	0.91792578
126	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.91470886
127	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.91200729
128	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.91013111
129	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.89324274
130	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.89215575
131	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.89209093
132	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88836222
133	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.88420880
134	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87933944
135	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87441082
136	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87380152
137	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.87355111
138	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.86388289
139	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.86040550
140	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85731810
141	GATA2_19941826_ChIP-Seq_K562_Human	0.84146868
142	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.82546877
143	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.82261850
144	BCOR_27268052_Chip-Seq_Bcells_Human	0.81344958
145	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.81154473
146	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.80205677
147	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.80001565
148	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.79751325
149	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.78937180
150	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.78782240
151	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.77524222
152	NCOR1_26117541_ChIP-Seq_K562_Human	0.77479820
153	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.76902593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.60486306
2	MP0001666_abnormal_nutrient_absorption	4.77593174
3	MP0002139_abnormal_hepatobiliary_system	4.55502130
4	MP0009840_abnormal_foam_cell	4.35220676
5	MP0005085_abnormal_gallbladder_physiolo	4.27274866
6	MP0009379_abnormal_foot_pigmentation	3.78602067
7	MP0003252_abnormal_bile_duct	3.57286944
8	MP0004264_abnormal_extraembryonic_tissu	3.31440546
9	MP0008875_abnormal_xenobiotic_pharmacok	3.24795163
10	MP0005365_abnormal_bile_salt	3.08340761
11	MP0010329_abnormal_lipoprotein_level	3.00237436
12	MP0010234_abnormal_vibrissa_follicle	2.87358047
13	MP0003705_abnormal_hypodermis_morpholog	2.57489731
14	MP0003806_abnormal_nucleotide_metabolis	2.40059544
15	MP0003183_abnormal_peptide_metabolism	2.26454660
16	MP0000462_abnormal_digestive_system	2.18822321
17	MP0004019_abnormal_vitamin_homeostasis	2.09621784
18	MP0010352_gastrointestinal_tract_polyps	2.09585886
19	MP0000678_abnormal_parathyroid_gland	2.08152954
20	MP0003866_abnormal_defecation	2.00234783
21	MP0001873_stomach_inflammation	1.95921981
22	MP0009780_abnormal_chondrocyte_physiolo	1.91428013
23	MP0005409_darkened_coat_color	1.87971868
24	MP0000490_abnormal_crypts_of	1.57996112
25	MP0010155_abnormal_intestine_physiology	1.57946176
26	MP0003693_abnormal_embryo_hatching	1.57464551
27	MP0002877_abnormal_melanocyte_morpholog	1.56822055
28	MP0001188_hyperpigmentation	1.55387242
29	MP0002822_catalepsy	1.54154095
30	MP0000477_abnormal_intestine_morphology	1.53819899
31	MP0003868_abnormal_feces_composition	1.53655360
32	MP0005166_decreased_susceptibility_to	1.52892833
33	MP0002876_abnormal_thyroid_physiology	1.52199768
34	MP0001663_abnormal_digestive_system	1.47125778
35	MP0000609_abnormal_liver_physiology	1.42239515
36	MP0004270_analgesia	1.41707926
37	MP0005381_digestive/alimentary_phenotyp	1.40722249
38	MP0005332_abnormal_amino_acid	1.39584591
39	MP0004858_abnormal_nervous_system	1.38167131
40	MP0002118_abnormal_lipid_homeostasis	1.33679438
41	MP0001765_abnormal_ion_homeostasis	1.31675719
42	MP0005636_abnormal_mineral_homeostasis	1.30126002
43	MP0003191_abnormal_cellular_cholesterol	1.23195634
44	MP0005084_abnormal_gallbladder_morpholo	1.19232411
45	MP0003718_maternal_effect	1.18792721
46	MP0003300_gastrointestinal_ulcer	1.15022732
47	MP0009643_abnormal_urine_homeostasis	1.14418258
48	MP0005666_abnormal_adipose_tissue	1.13468127
49	MP0000537_abnormal_urethra_morphology	1.09519084
50	MP0005377_hearing/vestibular/ear_phenot	1.08082446
51	MP0003878_abnormal_ear_physiology	1.08082446
52	MP0004043_abnormal_pH_regulation	1.07342162
53	MP0009384_cardiac_valve_regurgitation	1.06716919
54	MP0002138_abnormal_hepatobiliary_system	1.04509304
55	MP0002254_reproductive_system_inflammat	1.03345139
56	MP0004782_abnormal_surfactant_physiolog	1.02685205
57	MP0003136_yellow_coat_color	1.00514833
58	MP0005319_abnormal_enzyme/_coenzyme	0.99503928
59	MP0005451_abnormal_body_composition	0.99481836
60	MP0002796_impaired_skin_barrier	0.98984270
61	MP0001664_abnormal_digestion	0.97695963
62	MP0005448_abnormal_energy_balance	0.94430160
63	MP0003950_abnormal_plasma_membrane	0.93877434
64	MP0005535_abnormal_body_temperature	0.91616878
65	MP0002971_abnormal_brown_adipose	0.88913207
66	MP0001849_ear_inflammation	0.84636248
67	MP0002249_abnormal_larynx_morphology	0.84475582
68	MP0005083_abnormal_biliary_tract	0.84324415
69	MP0009697_abnormal_copulation	0.84178332
70	MP0005367_renal/urinary_system_phenotyp	0.83516609
71	MP0000516_abnormal_urinary_system	0.83516609
72	MP0005408_hypopigmentation	0.83258215
73	MP0010678_abnormal_skin_adnexa	0.83122723
74	MP0009115_abnormal_fat_cell	0.83062812
75	MP0001501_abnormal_sleep_pattern	0.82791719
76	MP0000538_abnormal_urinary_bladder	0.80489735
77	MP0005023_abnormal_wound_healing	0.79319968
78	MP0010307_abnormal_tumor_latency	0.78966309
79	MP0005670_abnormal_white_adipose	0.78936521
80	MP0003119_abnormal_digestive_system	0.77200145
81	MP0004147_increased_porphyrin_level	0.76816978
82	MP0000230_abnormal_systemic_arterial	0.75741152
83	MP0001845_abnormal_inflammatory_respons	0.75596111
84	MP0004957_abnormal_blastocyst_morpholog	0.75352809
85	MP0009053_abnormal_anal_canal	0.74880261
86	MP0005266_abnormal_metabolism	0.74687266
87	MP0005501_abnormal_skin_physiology	0.73085659
88	MP0005076_abnormal_cell_differentiation	0.72614029
89	MP0001485_abnormal_pinna_reflex	0.72225375
90	MP0000579_abnormal_nail_morphology	0.72186655
91	MP0005334_abnormal_fat_pad	0.71749655
92	MP0009333_abnormal_splenocyte_physiolog	0.71483156
93	MP0001764_abnormal_homeostasis	0.68950547
94	MP0000566_synostosis	0.68792382
95	MP0006054_spinal_hemorrhage	0.67798828
96	MP0005058_abnormal_lysosome_morphology	0.66860618
97	MP0001730_embryonic_growth_arrest	0.66322502
98	MP0000598_abnormal_liver_morphology	0.66140636
99	MP0003283_abnormal_digestive_organ	0.66048625
100	MP0000249_abnormal_blood_vessel	0.65942451
101	MP0003453_abnormal_keratinocyte_physiol	0.64941130
102	MP0008004_abnormal_stomach_pH	0.64670912
103	MP0004947_skin_inflammation	0.63449947
104	MP0008469_abnormal_protein_level	0.61526085
105	MP0005375_adipose_tissue_phenotype	0.60962749
106	MP0000604_amyloidosis	0.58574879
107	MP0002136_abnormal_kidney_physiology	0.58484200
108	MP0000681_abnormal_thyroid_gland	0.58357649
109	MP0002086_abnormal_extraembryonic_tissu	0.57660130
110	MP0009642_abnormal_blood_homeostasis	0.56990200
111	MP0005584_abnormal_enzyme/coenzyme_acti	0.56875269
112	MP0003111_abnormal_nucleus_morphology	0.56635743
113	MP0003566_abnormal_cell_adhesion	0.55806523
114	MP0004133_heterotaxia	0.55495043
115	MP0003879_abnormal_hair_cell	0.54667425
116	MP0003638_abnormal_response/metabolism_	0.53513036
117	MP0002098_abnormal_vibrissa_morphology	0.52406960
118	MP0009785_altered_susceptibility_to	0.51931659
119	MP0001756_abnormal_urination	0.50692526
120	MP0005376_homeostasis/metabolism_phenot	0.50424680
121	MP0001216_abnormal_epidermal_layer	0.48345853
122	MP0003953_abnormal_hormone_level	0.47008425
123	MP0008260_abnormal_autophagy	0.46897059
124	MP0000465_gastrointestinal_hemorrhage	0.46838362
125	MP0003329_amyloid_beta_deposits	0.46540649
126	MP0001881_abnormal_mammary_gland	0.46438004
127	MP0002078_abnormal_glucose_homeostasis	0.46355709
128	MP0001672_abnormal_embryogenesis/_devel	0.46214726
129	MP0005380_embryogenesis_phenotype	0.46214726
130	MP0005025_abnormal_response_to	0.45993383
131	MP0005174_abnormal_tail_pigmentation	0.44899982
132	MP0003436_decreased_susceptibility_to	0.44820653
133	MP0000427_abnormal_hair_cycle	0.44785345
134	MP0008872_abnormal_physiological_respon	0.44500960
135	MP0006138_congestive_heart_failure	0.44157272
136	MP0009764_decreased_sensitivity_to	0.42632305
137	MP0005165_increased_susceptibility_to	0.41739132
138	MP0000350_abnormal_cell_proliferation	0.41666633
139	MP0002653_abnormal_ependyma_morphology	0.41571715
140	MP0000467_abnormal_esophagus_morphology	0.40549118
141	MP0003303_peritoneal_inflammation	0.39191138
142	MP0000015_abnormal_ear_pigmentation	0.38471221

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ileus (HP:0002595)	6.41746862
2	Hypobetalipoproteinemia (HP:0003563)	6.35131267
3	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.18093867
4	Acanthocytosis (HP:0001927)	5.26875456
5	Malnutrition (HP:0004395)	4.94222097
6	Hyperglycinuria (HP:0003108)	4.72145453
7	Intrahepatic cholestasis (HP:0001406)	4.59634316
8	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.54585451
9	Systemic lupus erythematosus (HP:0002725)	4.40969185
10	Conjugated hyperbilirubinemia (HP:0002908)	4.36851855
11	Hydroxyprolinuria (HP:0003080)	4.32951127
12	Abnormality of proline metabolism (HP:0010907)	4.32951127
13	Hypolipoproteinemia (HP:0010981)	4.27434039
14	Right ventricular cardiomyopathy (HP:0011663)	4.22529326
15	Xanthomatosis (HP:0000991)	4.14231363
16	Fat malabsorption (HP:0002630)	3.97913772
17	Congenital sensorineural hearing impairment (HP:0008527)	3.74167969
18	Male infertility (HP:0003251)	3.59537173
19	Poikilocytosis (HP:0004447)	3.59307298
20	Abnormality of glycine metabolism (HP:0010895)	3.58861960
21	Abnormality of serine family amino acid metabolism (HP:0010894)	3.58861960
22	Abdominal distention (HP:0003270)	3.57076913
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.47741830
24	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.33037681
25	Autoimmune thrombocytopenia (HP:0001973)	3.30333273
26	Hyperuricemia (HP:0002149)	3.28936385
27	Increased purine levels (HP:0004368)	3.28936385
28	Wide cranial sutures (HP:0010537)	3.20062907
29	Pigmentary retinal degeneration (HP:0001146)	3.19333012
30	Alkalosis (HP:0001948)	3.18454685
31	Decreased circulating renin level (HP:0003351)	3.14744803
32	Hypercholesterolemia (HP:0003124)	3.06617870
33	Spastic paraparesis (HP:0002313)	3.05614518
34	Hypophosphatemia (HP:0002148)	3.02838058
35	Metabolic alkalosis (HP:0200114)	3.01690387
36	Epidermoid cyst (HP:0200040)	2.98480322
37	Thin bony cortex (HP:0002753)	2.95561634
38	Abnormality of pyrimidine metabolism (HP:0004353)	2.85121963
39	Hyperammonemia (HP:0001987)	2.79974744
40	Hyperactive renin-angiotensin system (HP:0000841)	2.74612827
41	Biliary tract neoplasm (HP:0100574)	2.73908361
42	Reticulocytosis (HP:0001923)	2.71347190
43	Abnormal urine phosphate concentration (HP:0012599)	2.71014880
44	Hyperphosphaturia (HP:0003109)	2.70605824
45	Abnormal biliary tract morphology (HP:0012440)	2.65662876
46	Hypoglycemic coma (HP:0001325)	2.65598236
47	Steatorrhea (HP:0002570)	2.63353686
48	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.62008391
49	Abnormality of nucleobase metabolism (HP:0010932)	2.60476514
50	Nausea (HP:0002018)	2.60005082
51	Hyperparathyroidism (HP:0000843)	2.56429992
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.55778036
53	Megaloblastic anemia (HP:0001889)	2.50553400
54	Abnormality of purine metabolism (HP:0004352)	2.48153789
55	Posterior subcapsular cataract (HP:0007787)	2.47749385
56	Chronic diarrhea (HP:0002028)	2.46926177
57	Hypoalphalipoproteinemia (HP:0003233)	2.46392638
58	Abnormality of magnesium homeostasis (HP:0004921)	2.41387676
59	Abnormality of renin-angiotensin system (HP:0000847)	2.40580476
60	Abnormality of vitamin metabolism (HP:0100508)	2.39860899
61	Confusion (HP:0001289)	2.38511989
62	Hypotension (HP:0002615)	2.37439592
63	Abnormality of vitamin B metabolism (HP:0004340)	2.36998434
64	Gout (HP:0001997)	2.33284936
65	Hemorrhage of the eye (HP:0011885)	2.32817699
66	Cupped ribs (HP:0000887)	2.32143708
67	Mesangial abnormality (HP:0001966)	2.31587801
68	Increased mean platelet volume (HP:0011877)	2.31235733
69	Widely patent fontanelles and sutures (HP:0004492)	2.30685166
70	Autoimmune hemolytic anemia (HP:0001890)	2.26942485
71	Dehydration (HP:0001944)	2.25740116
72	Metabolic acidosis (HP:0001942)	2.23955095
73	Renal tubular acidosis (HP:0001947)	2.23900877
74	Ketoacidosis (HP:0001993)	2.23144088
75	Gastrointestinal dysmotility (HP:0002579)	2.21453870
76	Delayed epiphyseal ossification (HP:0002663)	2.19183008
77	Esophageal varix (HP:0002040)	2.18855312
78	Skin nodule (HP:0200036)	2.17737139
79	Cerebral palsy (HP:0100021)	2.16381652
80	Glomerulonephritis (HP:0000099)	2.16174499
81	Abnormality of urine glucose concentration (HP:0011016)	2.15617296
82	Glycosuria (HP:0003076)	2.15617296
83	Protuberant abdomen (HP:0001538)	2.14065128
84	Eczematoid dermatitis (HP:0000976)	2.13472766
85	Congenital malformation of the right heart (HP:0011723)	2.13354663
86	Double outlet right ventricle (HP:0001719)	2.13354663
87	Rectal prolapse (HP:0002035)	2.11097577
88	Focal segmental glomerulosclerosis (HP:0000097)	2.10959349
89	Hyperglycinemia (HP:0002154)	2.10001743
90	Ketosis (HP:0001946)	2.07407371
91	Polycythemia (HP:0001901)	2.05107852
92	Abnormality of complement system (HP:0005339)	2.04727406
93	Hyperbilirubinemia (HP:0002904)	2.03813027
94	Complement deficiency (HP:0004431)	2.03694411
95	Syncope (HP:0001279)	2.02517493
96	Petechiae (HP:0000967)	2.01423906
97	Abnormal platelet volume (HP:0011876)	2.00874848
98	Irritability (HP:0000737)	1.99449606
99	Abnormality of the costochondral junction (HP:0000919)	1.99215558
100	Hyperphosphatemia (HP:0002905)	1.98011461
101	Enlarged epiphyses (HP:0010580)	1.97962606
102	Back pain (HP:0003418)	1.97227243
103	Impulsivity (HP:0100710)	1.93369950
104	Micronodular cirrhosis (HP:0001413)	1.92922039
105	Cholecystitis (HP:0001082)	1.92230580
106	Abnormal gallbladder physiology (HP:0012438)	1.92230580
107	Hyperlipoproteinemia (HP:0010980)	1.90619285
108	Generalized aminoaciduria (HP:0002909)	1.90270642
109	Paraparesis (HP:0002385)	1.90041648
110	Dicarboxylic aciduria (HP:0003215)	1.89917790
111	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89917790
112	Flat acetabular roof (HP:0003180)	1.89545316
113	Ependymoma (HP:0002888)	1.89461976
114	Renal tubular dysfunction (HP:0000124)	1.89274716
115	Palpitations (HP:0001962)	1.88125048
116	Subcapsular cataract (HP:0000523)	1.88062843
117	Nephrolithiasis (HP:0000787)	1.84398426
118	Deep venous thrombosis (HP:0002625)	1.84014665
119	Abnormality of alkaline phosphatase activity (HP:0004379)	1.82964826
120	Abnormal enzyme/coenzyme activity (HP:0012379)	1.80523227
121	Urethral obstruction (HP:0000796)	1.80335372
122	Pili torti (HP:0003777)	1.79153326
123	Nephritis (HP:0000123)	1.77844708
124	Prolonged partial thromboplastin time (HP:0003645)	1.77233148
125	Hypocalcemia (HP:0002901)	1.76239819
126	Abnormality of the gastric mucosa (HP:0004295)	1.74777294
127	Pancreatitis (HP:0001733)	1.74565337
128	Tetany (HP:0001281)	1.74051584
129	Uterine neoplasm (HP:0010784)	1.73146778
130	Short humerus (HP:0005792)	1.72102411
131	Facial shape deformation (HP:0011334)	1.72068886
132	Potter facies (HP:0002009)	1.72068886
133	Multiple lipomas (HP:0001012)	1.71017783
134	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.70518692
135	Late onset (HP:0003584)	1.70293360
136	White forelock (HP:0002211)	1.69800958
137	Vomiting (HP:0002013)	1.69354616
138	Proximal tubulopathy (HP:0000114)	1.68790833
139	Abnormal glucose tolerance (HP:0001952)	1.67781589
140	Abnormality of reticulocytes (HP:0004312)	1.66997920
141	Growth hormone excess (HP:0000845)	1.66243074
142	Reduced antithrombin III activity (HP:0001976)	1.64922055
143	Pseudobulbar signs (HP:0002200)	1.63855470
144	Lethargy (HP:0001254)	1.63548455
145	Abnormality of small intestinal villus morphology (HP:0011472)	1.60756887
146	Villous atrophy (HP:0011473)	1.60756887
147	Neoplasm of the small intestine (HP:0100833)	1.60570617
148	Combined immunodeficiency (HP:0005387)	1.60418784
149	Ovarian neoplasm (HP:0100615)	1.60296816
150	Aplasia/hypoplasia of the humerus (HP:0006507)	1.60179280

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	7.59412964
2	NME1	5.02610902
3	FRK	4.46430253
4	EPHA2	3.92277574
5	LMTK2	3.56846591
6	SMG1	3.56834670
7	ERN1	3.42289021
8	MST4	3.23555083
9	MST1R	2.95264331
10	CDK12	2.83731661
11	AKT3	2.76961813
12	PTK6	2.45963203
13	VRK2	2.34857868
14	TAF1	2.23739125
15	GRK6	2.19031313
16	EEF2K	2.12913640
17	RPS6KB2	2.04120030
18	TESK1	1.98890486
19	MAP3K10	1.95981168
20	PRKG2	1.92421869
21	PKN2	1.90802357
22	BMX	1.70028863
23	TTK	1.66808682
24	MET	1.66157421
25	TNIK	1.63625425
26	TYK2	1.62591554
27	SRPK1	1.62274597
28	PDK2	1.60543329
29	MUSK	1.56319356
30	RIPK1	1.46448638
31	STK10	1.36430563
32	MAP3K12	1.34694351
33	MAP2K2	1.28548540
34	PAK4	1.28036037
35	LATS1	1.26621538
36	PIK3CA	1.24988757
37	NEK1	1.23920394
38	MAP3K8	1.16565705
39	TAOK3	1.16156636
40	STK24	1.14386154
41	PIK3CG	1.13022897
42	PRKCI	1.12325774
43	ICK	1.11596330
44	MATK	1.11263813
45	MYLK	1.09664814
46	BRD4	1.08978270
47	GRK5	1.04497170
48	STK39	1.03559811
49	MAP3K7	1.03371573
50	ERBB4	1.03094494
51	MAPK11	1.01959470
52	TRIB3	0.98448690
53	SCYL2	0.96820129
54	EPHA4	0.96686728
55	RIPK4	0.95486421
56	NEK2	0.94945566
57	PTK2	0.94073228
58	OXSR1	0.93915841
59	ABL2	0.90890627
60	CDK6	0.89828741
61	EPHA3	0.89809981
62	AURKB	0.84288176
63	DAPK1	0.79872965
64	ZAK	0.79698877
65	PIM2	0.79404258
66	PRPF4B	0.79284564
67	PDPK1	0.78216217
68	CDK4	0.77564603
69	MAP3K11	0.76811515
70	EPHB2	0.74209015
71	ALK	0.72341365
72	PRKAA2	0.71943724
73	GRK1	0.70185809
74	IRAK4	0.69745893
75	MAP3K2	0.69344571
76	TESK2	0.69257702
77	PRKD3	0.67253984
78	CDC42BPA	0.65467052
79	IRAK2	0.64090982
80	IRAK1	0.62928608
81	ERBB2	0.62243106
82	MTOR	0.61714231
83	CDC7	0.60350465
84	SIK1	0.59567682
85	CDK19	0.59423952
86	DAPK3	0.59293728
87	MAPKAPK5	0.58437500
88	LIMK1	0.57152112
89	TBK1	0.56593207
90	WEE1	0.56087120
91	DYRK1B	0.55257319
92	CSK	0.54899353
93	BCKDK	0.54109870
94	INSRR	0.53752900
95	AKT2	0.53201849
96	PRKCA	0.52428683
97	CDK7	0.50415095
98	PRKCZ	0.50083435
99	DDR2	0.49174368
100	LRRK2	0.48964880
101	NUAK1	0.48513828
102	PAK1	0.47381437
103	KDR	0.46540209
104	FGFR3	0.44993592
105	IRAK3	0.44628092
106	TTN	0.43748149
107	PRKAA1	0.43185133
108	PDK1	0.42998117
109	PDK4	0.42775020
110	PDK3	0.42775020
111	CASK	0.42101297
112	STK16	0.42070279
113	CAMK1D	0.41959356
114	NLK	0.41850499
115	CHEK2	0.41243091
116	TAOK1	0.38699909
117	FGR	0.37897697
118	PLK1	0.36855730
119	PDGFRA	0.36450101
120	RPS6KB1	0.36434892
121	SRC	0.36116508
122	EIF2AK1	0.35056517
123	PIM1	0.34990097
124	STK3	0.34543375
125	CAMK2G	0.34121893
126	CAMK2B	0.33923791
127	CSNK1E	0.33765103
128	STK4	0.33019180
129	MAP4K1	0.32786432
130	PRKCD	0.31960296
131	CHUK	0.31386523
132	FER	0.30376637
133	BRAF	0.30246217
134	MELK	0.29940320
135	MAPK4	0.28535106
136	EPHB1	0.27963264
137	PRKACG	0.26944556
138	CDK9	0.26731473
139	MAP3K1	0.26395137
140	CDK2	0.26323075
141	CAMK2D	0.25938064
142	BUB1	0.24897321
143	MAPKAPK2	0.24106222
144	FGFR4	0.23440981
145	FYN	0.22441034
146	ZAP70	0.22387113
147	GSK3A	0.21959052
148	RET	0.21349232
149	CSF1R	0.18618835
150	MAP2K6	0.18189171
151	KSR2	0.17445379

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fat digestion and absorption_Homo sapiens_hsa04975	5.25614877
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.17294909
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.24891702
4	Renin-angiotensin system_Homo sapiens_hsa04614	3.00975309
5	Folate biosynthesis_Homo sapiens_hsa00790	2.67365447
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.50020899
7	Mineral absorption_Homo sapiens_hsa04978	2.48439573
8	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.40154250
9	Sulfur metabolism_Homo sapiens_hsa00920	2.39492915
10	Galactose metabolism_Homo sapiens_hsa00052	2.35275808
11	Caffeine metabolism_Homo sapiens_hsa00232	2.20053345
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.09763311
13	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.09160792
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.02527054
15	Bile secretion_Homo sapiens_hsa04976	1.99757062
16	Arginine biosynthesis_Homo sapiens_hsa00220	1.94448328
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.94330005
18	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.85258433
19	Fatty acid degradation_Homo sapiens_hsa00071	1.81647394
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.77380287
21	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.76687341
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.75604259
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.61100443
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.58619610
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57694583
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.55936530
27	Sulfur relay system_Homo sapiens_hsa04122	1.53111362
28	Glutathione metabolism_Homo sapiens_hsa00480	1.52335671
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.50324188
30	Histidine metabolism_Homo sapiens_hsa00340	1.49018761
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.47443672
32	Protein digestion and absorption_Homo sapiens_hsa04974	1.46242246
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39610182
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.39290853
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37519519
36	Carbon metabolism_Homo sapiens_hsa01200	1.37233560
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30344085
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.26297648
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.22005559
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21764075
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19595342
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16319274
43	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.14595593
44	Pentose phosphate pathway_Homo sapiens_hsa00030	1.10344011
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.10236132
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07569865
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06979655
48	Asthma_Homo sapiens_hsa05310	1.04173396
49	Pyruvate metabolism_Homo sapiens_hsa00620	1.01090182
50	Lysine degradation_Homo sapiens_hsa00310	1.00864987
51	ABC transporters_Homo sapiens_hsa02010	0.98512707
52	One carbon pool by folate_Homo sapiens_hsa00670	0.96358470
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95281530
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.91882128
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.91199250
56	Propanoate metabolism_Homo sapiens_hsa00640	0.84591450
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84525864
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84458925
59	Retinol metabolism_Homo sapiens_hsa00830	0.81595797
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81202949
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77658723
62	Butanoate metabolism_Homo sapiens_hsa00650	0.77414337
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70033530
64	Peroxisome_Homo sapiens_hsa04146	0.69355999
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64527305
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62143915
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.62078361
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.60873653
69	Allograft rejection_Homo sapiens_hsa05330	0.60680693
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60513852
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59757983
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.59352056
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52015062
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.50751689
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49031105
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48952473
77	Other glycan degradation_Homo sapiens_hsa00511	0.48866986
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46865306
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44996601
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41039942
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40808382
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40678707
83	Metabolic pathways_Homo sapiens_hsa01100	0.40242962
84	Tight junction_Homo sapiens_hsa04530	0.40074419
85	Fatty acid elongation_Homo sapiens_hsa00062	0.34616480
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32581259
87	Thyroid cancer_Homo sapiens_hsa05216	0.32367705
88	Pancreatic secretion_Homo sapiens_hsa04972	0.30551762
89	Complement and coagulation cascades_Homo sapiens_hsa04610	0.28901985
90	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.28662001
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.27744762
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26647447
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.26620117
94	Bladder cancer_Homo sapiens_hsa05219	0.26005954
95	Hepatitis C_Homo sapiens_hsa05160	0.25327112
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.23844101
97	Base excision repair_Homo sapiens_hsa03410	0.23728139
98	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.23280654
99	Antigen processing and presentation_Homo sapiens_hsa04612	0.22357543
100	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20609156
101	Insulin resistance_Homo sapiens_hsa04931	0.20423016
102	Renin secretion_Homo sapiens_hsa04924	0.19688683
103	Pyrimidine metabolism_Homo sapiens_hsa00240	0.17511113
104	Cocaine addiction_Homo sapiens_hsa05030	0.17297038
105	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16455554
106	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.15089241
107	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.14337215
108	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.14157925
109	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.14043388
110	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.13599039
111	Adherens junction_Homo sapiens_hsa04520	0.12225619
112	Pertussis_Homo sapiens_hsa05133	0.11647508
113	Leishmaniasis_Homo sapiens_hsa05140	0.10193558
114	Tyrosine metabolism_Homo sapiens_hsa00350	0.09621547
115	Purine metabolism_Homo sapiens_hsa00230	0.08838943
116	Glucagon signaling pathway_Homo sapiens_hsa04922	0.07570008
117	Ether lipid metabolism_Homo sapiens_hsa00565	0.07424368
118	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.06313919
119	DNA replication_Homo sapiens_hsa03030	0.05107854
120	Mismatch repair_Homo sapiens_hsa03430	0.04938997
121	AMPK signaling pathway_Homo sapiens_hsa04152	0.03884847
122	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.03459473
123	Small cell lung cancer_Homo sapiens_hsa05222	0.03452981
124	Insulin signaling pathway_Homo sapiens_hsa04910	0.00509975
125	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	-0.0254390
126	African trypanosomiasis_Homo sapiens_hsa05143	-0.0236560

TMEM253

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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