ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	6.68828857
2	epithelial cilium movement (GO:0003351)	5.89169885
3	cilium movement (GO:0003341)	5.76086944
4	regulation of cilium movement (GO:0003352)	5.17977099
5	cilium or flagellum-dependent cell motility (GO:0001539)	5.13525320
6	intraciliary transport (GO:0042073)	5.11939692
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.07138970
8	axoneme assembly (GO:0035082)	4.67481511
9	nonmotile primary cilium assembly (GO:0035058)	4.19812050
10	aldehyde catabolic process (GO:0046185)	3.74498486
11	positive regulation of mitochondrial fission (GO:0090141)	3.73557980
12	cullin deneddylation (GO:0010388)	3.70594486
13	protein localization to cilium (GO:0061512)	3.69736130
14	cilium organization (GO:0044782)	3.66185720
15	cilium assembly (GO:0042384)	3.62804826
16	GPI anchor metabolic process (GO:0006505)	3.56049093
17	GPI anchor biosynthetic process (GO:0006506)	3.52202206
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.44605780
19	cilium morphogenesis (GO:0060271)	3.43531623
20	motile cilium assembly (GO:0044458)	3.43481208
21	protein deneddylation (GO:0000338)	3.43312950
22	primary alcohol catabolic process (GO:0034310)	3.42010053
23	left/right pattern formation (GO:0060972)	3.40402998
24	proteasome assembly (GO:0043248)	3.28347510
25	chaperone-mediated protein transport (GO:0072321)	3.28231316
26	isoprenoid biosynthetic process (GO:0008299)	3.24584670
27	cholesterol biosynthetic process (GO:0006695)	3.22429826
28	regulation of microtubule-based movement (GO:0060632)	3.18506259
29	mannosylation (GO:0097502)	3.16466548
30	sterol biosynthetic process (GO:0016126)	3.14354356
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.12127935
32	response to nitrosative stress (GO:0051409)	3.11979160
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10038555
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.02829843
35	left/right axis specification (GO:0070986)	3.01314220
36	glutathione derivative biosynthetic process (GO:1901687)	2.99793443
37	glutathione derivative metabolic process (GO:1901685)	2.99793443
38	ubiquinone metabolic process (GO:0006743)	2.99216589
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98986913
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98986913
41	C-terminal protein lipidation (GO:0006501)	2.98906197
42	response to pheromone (GO:0019236)	2.96868542
43	DNA damage response, detection of DNA damage (GO:0042769)	2.94759229
44	branched-chain amino acid catabolic process (GO:0009083)	2.92323788
45	pyrimidine nucleobase catabolic process (GO:0006208)	2.91675153
46	peptidyl-cysteine modification (GO:0018198)	2.88141595
47	C-terminal protein amino acid modification (GO:0018410)	2.87008430
48	DNA double-strand break processing (GO:0000729)	2.85209893
49	protein neddylation (GO:0045116)	2.84749223
50	ubiquinone biosynthetic process (GO:0006744)	2.84525875
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.83779952
52	terpenoid biosynthetic process (GO:0016114)	2.83129869
53	fatty acid elongation (GO:0030497)	2.79958215
54	cornea development in camera-type eye (GO:0061303)	2.79772257
55	glycolipid biosynthetic process (GO:0009247)	2.77938856
56	L-serine metabolic process (GO:0006563)	2.76271883
57	microtubule bundle formation (GO:0001578)	2.75141138
58	base-excision repair, AP site formation (GO:0006285)	2.74496921
59	photoreceptor cell maintenance (GO:0045494)	2.74483316
60	nucleoside diphosphate phosphorylation (GO:0006165)	2.74246346
61	platelet dense granule organization (GO:0060155)	2.72603509
62	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.67963558
63	ATP synthesis coupled proton transport (GO:0015986)	2.67963558
64	protein complex biogenesis (GO:0070271)	2.67950629
65	peptidyl-histidine modification (GO:0018202)	2.66312903
66	cellular component assembly involved in morphogenesis (GO:0010927)	2.63047735
67	GTP biosynthetic process (GO:0006183)	2.63020384
68	carnitine metabolic process (GO:0009437)	2.60489481
69	respiratory chain complex IV assembly (GO:0008535)	2.59842505
70	sequestering of actin monomers (GO:0042989)	2.59606488
71	electron transport chain (GO:0022900)	2.56770263
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56236827
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56236827
74	NADH dehydrogenase complex assembly (GO:0010257)	2.56236827
75	ethanol metabolic process (GO:0006067)	2.55001673
76	nucleotide transmembrane transport (GO:1901679)	2.54297257
77	regulation of cellular amino acid metabolic process (GO:0006521)	2.53855671
78	respiratory electron transport chain (GO:0022904)	2.53089582
79	quinone biosynthetic process (GO:1901663)	2.52077473
80	quinone metabolic process (GO:1901661)	2.51889536
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51770083
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51264875
83	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.48460666
84	histone H2A acetylation (GO:0043968)	2.45175502
85	keratinocyte development (GO:0003334)	2.45068974
86	vitamin transmembrane transport (GO:0035461)	2.43173959
87	serine family amino acid catabolic process (GO:0009071)	2.41776666
88	organelle disassembly (GO:1903008)	2.39871317
89	protein polyglutamylation (GO:0018095)	2.39519232
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.38868178
91	peroxisome fission (GO:0016559)	2.37676454
92	amino-acid betaine metabolic process (GO:0006577)	2.37463138
93	retinal rod cell development (GO:0046548)	2.36106705
94	nucleobase catabolic process (GO:0046113)	2.33881854
95	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.33672544
96	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.33121720
97	cell projection assembly (GO:0030031)	2.32752124
98	xenobiotic catabolic process (GO:0042178)	2.30591729
99	chromatin remodeling at centromere (GO:0031055)	2.28236729
100	glyoxylate metabolic process (GO:0046487)	2.26095385

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.90413395
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.71017211
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54364556
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.81111872
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73641087
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55344283
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50341919
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45331369
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28892513
10	VDR_22108803_ChIP-Seq_LS180_Human	2.19254652
11	FUS_26573619_Chip-Seq_HEK293_Human	2.18323833
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.11666959
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10681280
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08820531
15	EWS_26573619_Chip-Seq_HEK293_Human	2.07811659
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.92448552
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.89139109
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87659046
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82532989
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.81912183
21	P300_19829295_ChIP-Seq_ESCs_Human	1.79159011
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.76573525
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.71506852
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69262778
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66645911
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65688285
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64861446
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62652349
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61168215
30	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.60068502
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54760740
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54341694
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53236351
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.52946114
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50418132
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48609170
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45749290
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.44431763
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42342493
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.42012719
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40604017
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.39220022
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37237381
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.33256238
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33256238
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31375751
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31050742
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30565565
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27700312
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27261100
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26399741
52	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25514136
53	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24125922
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22498482
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19670147
56	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16714016
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16198428
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16005085
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16005085
60	AR_20517297_ChIP-Seq_VCAP_Human	1.14334437
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.11896322
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.10756328
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10385294
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.10348280
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07105263
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06725298
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06316160
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06112347
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06112347
70	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.04552968
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.04273129
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04197859
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04063634
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03480102
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03196126
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02698627
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02646525
78	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.01902308
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01626013
80	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01194639
81	AR_25329375_ChIP-Seq_VCAP_Human	1.01113032
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00353905
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99043441
84	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97648491
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97163081
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96696663
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96276778
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94521622
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94150261
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93544330
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93255267
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.92724650
93	EOMES_21245162_ChIP-Seq_HESCs_Human	0.91894531
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91693154
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90768477
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.90558169
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89836952
98	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.89820633
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.89321757
100	NCOR_22424771_ChIP-Seq_293T_Human	0.88929277

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	3.56175967
2	MP0008789_abnormal_olfactory_epithelium	3.50953132
3	MP0001984_abnormal_olfaction	3.08843160
4	MP0005499_abnormal_olfactory_system	3.07968080
5	MP0005394_taste/olfaction_phenotype	3.07968080
6	MP0001529_abnormal_vocalization	2.61622546
7	MP0008875_abnormal_xenobiotic_pharmacok	2.59741940
8	MP0003880_abnormal_central_pattern	2.50119857
9	MP0003122_maternal_imprinting	2.48008636
10	MP0006072_abnormal_retinal_apoptosis	2.19617888
11	MP0003011_delayed_dark_adaptation	2.13561672
12	MP0002102_abnormal_ear_morphology	1.92214243
13	MP0001293_anophthalmia	1.87559813
14	MP0003136_yellow_coat_color	1.83985265
15	MP0000372_irregular_coat_pigmentation	1.80119913
16	MP0004133_heterotaxia	1.78821427
17	MP0005253_abnormal_eye_physiology	1.72319371
18	MP0000647_abnormal_sebaceous_gland	1.71001856
19	MP0006292_abnormal_olfactory_placode	1.69867833
20	MP0002282_abnormal_trachea_morphology	1.67583993
21	MP0002938_white_spotting	1.67579793
22	MP0005248_abnormal_Harderian_gland	1.66521385
23	MP0005075_abnormal_melanosome_morpholog	1.66029893
24	MP0000566_synostosis	1.65550239
25	MP0002233_abnormal_nose_morphology	1.62820112
26	MP0006276_abnormal_autonomic_nervous	1.58749541
27	MP0004147_increased_porphyrin_level	1.58293149
28	MP0008877_abnormal_DNA_methylation	1.53859425
29	MP0002234_abnormal_pharynx_morphology	1.51318340
30	MP0003878_abnormal_ear_physiology	1.50807797
31	MP0005377_hearing/vestibular/ear_phenot	1.50807797
32	MP0003121_genomic_imprinting	1.47605414
33	MP0002277_abnormal_respiratory_mucosa	1.47457747
34	MP0003941_abnormal_skin_development	1.46744097
35	MP0005551_abnormal_eye_electrophysiolog	1.40226606
36	MP0008058_abnormal_DNA_repair	1.38798007
37	MP0003890_abnormal_embryonic-extraembry	1.38016930
38	MP0003195_calcinosis	1.37852825
39	MP0000049_abnormal_middle_ear	1.33499335
40	MP0002090_abnormal_vision	1.31393505
41	MP0002751_abnormal_autonomic_nervous	1.29034340
42	MP0002098_abnormal_vibrissa_morphology	1.28775306
43	MP0001188_hyperpigmentation	1.27989087
44	MP0003186_abnormal_redox_activity	1.25774844
45	MP0003718_maternal_effect	1.24516285
46	MP0005408_hypopigmentation	1.22661223
47	MP0000427_abnormal_hair_cycle	1.20697722
48	MP0000778_abnormal_nervous_system	1.19434070
49	MP0002160_abnormal_reproductive_system	1.18528035
50	MP0003937_abnormal_limbs/digits/tail_de	1.17535436
51	MP0000383_abnormal_hair_follicle	1.16078310
52	MP0001485_abnormal_pinna_reflex	1.15859348
53	MP0002822_catalepsy	1.15432549
54	MP0003119_abnormal_digestive_system	1.13909154
55	MP0002132_abnormal_respiratory_system	1.13841384
56	MP0004043_abnormal_pH_regulation	1.08327456
57	MP0002736_abnormal_nociception_after	1.07006908
58	MP0010030_abnormal_orbit_morphology	1.05455977
59	MP0008995_early_reproductive_senescence	1.04471722
60	MP0003787_abnormal_imprinting	1.04002692
61	MP0006054_spinal_hemorrhage	1.03992426
62	MP0010678_abnormal_skin_adnexa	1.03907118
63	MP0005085_abnormal_gallbladder_physiolo	1.02707304
64	MP0004019_abnormal_vitamin_homeostasis	1.02068590
65	MP0001324_abnormal_eye_pigmentation	1.01528678
66	MP0005391_vision/eye_phenotype	1.00616319
67	MP0006036_abnormal_mitochondrial_physio	1.00429143
68	MP0000631_abnormal_neuroendocrine_gland	0.99870778
69	MP0004142_abnormal_muscle_tone	0.96899931
70	MP0003938_abnormal_ear_development	0.96640038
71	MP0009780_abnormal_chondrocyte_physiolo	0.94704688
72	MP0000026_abnormal_inner_ear	0.93545149
73	MP0000516_abnormal_urinary_system	0.91548066
74	MP0005367_renal/urinary_system_phenotyp	0.91548066
75	MP0002796_impaired_skin_barrier	0.90891419
76	MP0002095_abnormal_skin_pigmentation	0.89572949
77	MP0005195_abnormal_posterior_eye	0.88954440
78	MP0001286_abnormal_eye_development	0.87837179
79	MP0005084_abnormal_gallbladder_morpholo	0.87561578
80	MP0003755_abnormal_palate_morphology	0.85927677
81	MP0008932_abnormal_embryonic_tissue	0.85219658
82	MP0002557_abnormal_social/conspecific_i	0.84952067
83	MP0005389_reproductive_system_phenotype	0.83891809
84	MP0002752_abnormal_somatic_nervous	0.81145791
85	MP0000579_abnormal_nail_morphology	0.80342901
86	MP0010386_abnormal_urinary_bladder	0.80153348
87	MP0009046_muscle_twitch	0.79207533
88	MP0001905_abnormal_dopamine_level	0.77768017
89	MP0002909_abnormal_adrenal_gland	0.76891500
90	MP0010234_abnormal_vibrissa_follicle	0.76497331
91	MP0002837_dystrophic_cardiac_calcinosis	0.76024420
92	MP0005636_abnormal_mineral_homeostasis	0.75646199
93	MP0010094_abnormal_chromosome_stability	0.75596336
94	MP0005365_abnormal_bile_salt	0.75511126
95	MP0001764_abnormal_homeostasis	0.75245755
96	MP0001486_abnormal_startle_reflex	0.75203698
97	MP0002638_abnormal_pupillary_reflex	0.71456616
98	MP0006035_abnormal_mitochondrial_morpho	0.71203812
99	MP0002272_abnormal_nervous_system	0.69320518
100	MP0003315_abnormal_perineum_morphology	0.67671964

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.04098277
2	Abnormal respiratory epithelium morphology (HP:0012253)	5.35689582
3	Abnormal respiratory motile cilium morphology (HP:0005938)	5.35689582
4	Abnormal respiratory motile cilium physiology (HP:0012261)	5.24891519
5	Abnormal ciliary motility (HP:0012262)	4.92798823
6	Absent/shortened dynein arms (HP:0200106)	4.81874252
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.81874252
8	Rhinitis (HP:0012384)	4.78942063
9	True hermaphroditism (HP:0010459)	4.04781733
10	Medial flaring of the eyebrow (HP:0010747)	3.89240088
11	Chronic bronchitis (HP:0004469)	3.87702937
12	Congenital primary aphakia (HP:0007707)	3.73578841
13	Pancreatic fibrosis (HP:0100732)	3.71346455
14	Gait imbalance (HP:0002141)	3.67675154
15	Nephrogenic diabetes insipidus (HP:0009806)	3.54319556
16	Pancreatic cysts (HP:0001737)	3.31393478
17	Abnormality of midbrain morphology (HP:0002418)	3.27117387
18	Molar tooth sign on MRI (HP:0002419)	3.27117387
19	Bronchiectasis (HP:0002110)	3.00561557
20	Occipital encephalocele (HP:0002085)	2.97012912
21	Vaginal atresia (HP:0000148)	2.92826284
22	Genital tract atresia (HP:0001827)	2.92178393
23	Nephronophthisis (HP:0000090)	2.86287666
24	Acute necrotizing encephalopathy (HP:0006965)	2.77336120
25	Postaxial foot polydactyly (HP:0001830)	2.73507588
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.65374902
27	Acute encephalopathy (HP:0006846)	2.61129935
28	Hyperglycinemia (HP:0002154)	2.59631887
29	Postaxial hand polydactyly (HP:0001162)	2.53423833
30	Mitochondrial inheritance (HP:0001427)	2.46140612
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.43096260
32	Anencephaly (HP:0002323)	2.42028770
33	Cystic liver disease (HP:0006706)	2.38478021
34	Sclerocornea (HP:0000647)	2.38382047
35	Tubulointerstitial nephritis (HP:0001970)	2.36887572
36	Abnormality of the labia minora (HP:0012880)	2.34549663
37	Abnormality of the renal medulla (HP:0100957)	2.33645736
38	Poor coordination (HP:0002370)	2.31175322
39	Progressive macrocephaly (HP:0004481)	2.30908483
40	Male pseudohermaphroditism (HP:0000037)	2.28819339
41	Median cleft lip (HP:0000161)	2.26932947
42	Hepatocellular necrosis (HP:0001404)	2.26701142
43	Decreased testicular size (HP:0008734)	2.21556890
44	Increased CSF lactate (HP:0002490)	2.16639495
45	Abnormality of glycine metabolism (HP:0010895)	2.14538574
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.14538574
47	Broad foot (HP:0001769)	2.11929979
48	Hyperglycinuria (HP:0003108)	2.10501055
49	Colon cancer (HP:0003003)	2.10500791
50	Congenital hepatic fibrosis (HP:0002612)	2.07864363
51	Hepatic necrosis (HP:0002605)	2.07084798
52	Bifid tongue (HP:0010297)	2.06390323
53	Preaxial hand polydactyly (HP:0001177)	2.06046643
54	Abnormal protein glycosylation (HP:0012346)	2.04906530
55	Abnormal glycosylation (HP:0012345)	2.04906530
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04906530
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.04906530
58	Abnormality of the anterior horn cell (HP:0006802)	2.03251419
59	Degeneration of anterior horn cells (HP:0002398)	2.03251419
60	Abolished electroretinogram (ERG) (HP:0000550)	2.02397060
61	Increased hepatocellular lipid droplets (HP:0006565)	2.01206310
62	Specific learning disability (HP:0001328)	1.99647769
63	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97294264
64	Lipid accumulation in hepatocytes (HP:0006561)	1.97156672
65	Oculomotor apraxia (HP:0000657)	1.95745103
66	Type I transferrin isoform profile (HP:0003642)	1.93496604
67	Renal Fanconi syndrome (HP:0001994)	1.88724458
68	Cerebral edema (HP:0002181)	1.87038139
69	Anophthalmia (HP:0000528)	1.85226528
70	Labial hypoplasia (HP:0000066)	1.84425949
71	Aganglionic megacolon (HP:0002251)	1.83487267
72	Supernumerary spleens (HP:0009799)	1.83253706
73	Infertility (HP:0000789)	1.81404206
74	3-Methylglutaconic aciduria (HP:0003535)	1.79934351
75	Methylmalonic acidemia (HP:0002912)	1.79875519
76	Short tibia (HP:0005736)	1.77125103
77	Polyphagia (HP:0002591)	1.76906869
78	Septo-optic dysplasia (HP:0100842)	1.75617487
79	Furrowed tongue (HP:0000221)	1.74020129
80	Hypoplastic female external genitalia (HP:0012815)	1.73397966
81	Chronic hepatic failure (HP:0100626)	1.71359356
82	Hip dysplasia (HP:0001385)	1.71234877
83	Narrow forehead (HP:0000341)	1.69880005
84	Aplasia/Hypoplasia of the lens (HP:0008063)	1.69877241
85	Hypoplasia of the uterus (HP:0000013)	1.69239244
86	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.67020845
87	Increased serum pyruvate (HP:0003542)	1.66603044
88	Retinitis pigmentosa (HP:0000510)	1.60875628
89	Abnormality of serum amino acid levels (HP:0003112)	1.60559582
90	Intestinal atresia (HP:0011100)	1.60227460
91	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.59685439
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.59627904
93	Bile duct proliferation (HP:0001408)	1.58761505
94	Abnormal biliary tract physiology (HP:0012439)	1.58761505
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.58206232
96	Gonadotropin excess (HP:0000837)	1.57819020
97	Lactic acidosis (HP:0003128)	1.56100283
98	Congenital ichthyosiform erythroderma (HP:0007431)	1.55165929
99	Abnormality of macular pigmentation (HP:0008002)	1.53782669
100	Abnormality of glycolysis (HP:0004366)	1.53688737

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.42281005
2	WNK3	3.10455322
3	MST4	3.07354253
4	MAP4K2	3.00748548
5	BCR	2.90749063
6	MAP3K4	2.57590274
7	MAP2K7	2.39248315
8	ERBB3	2.30925509
9	BCKDK	2.23688470
10	VRK2	2.05267745
11	CDK19	1.97307804
12	MAPK15	1.91194311
13	SRPK1	1.78603983
14	STK16	1.72992361
15	NUAK1	1.70298997
16	BRSK2	1.68016670
17	TNIK	1.61323376
18	MKNK1	1.61227630
19	DYRK2	1.59971167
20	CSNK1G1	1.58333990
21	BMPR1B	1.54323715
22	EIF2AK3	1.52816272
23	CSNK1G3	1.51698725
24	EPHA2	1.49523455
25	TSSK6	1.49365350
26	CASK	1.47646082
27	CSNK1G2	1.45792027
28	FER	1.40836447
29	CSNK1A1L	1.39141068
30	BUB1	1.35875563
31	EPHA3	1.31161166
32	NME1	1.30983735
33	EIF2AK1	1.29302371
34	PLK3	1.28985028
35	MAPK13	1.26821186
36	FRK	1.26138248
37	LIMK1	1.24722146
38	FLT3	1.23135361
39	MAP3K12	1.20749624
40	TESK1	1.20104662
41	TTK	1.18805997
42	GRK1	1.17426763
43	PBK	1.15366501
44	STK38L	1.14726144
45	EPHA4	1.14331024
46	ZAK	1.12983008
47	MUSK	1.12268304
48	PINK1	1.11577955
49	OXSR1	1.11257203
50	PRKD3	1.10536523
51	WEE1	1.07131104
52	VRK1	1.05169012
53	NEK1	1.04917628
54	PLK4	1.03850899
55	DYRK3	1.02393094
56	ADRBK2	1.00765061
57	PAK3	1.00557915
58	MKNK2	0.97869017
59	PLK2	0.90627062
60	BRSK1	0.88345426
61	TAF1	0.79860587
62	PRKCE	0.79000102
63	INSRR	0.78982512
64	TAOK3	0.75096840
65	PLK1	0.74885897
66	MAP2K4	0.74741623
67	CCNB1	0.72288766
68	SIK3	0.69822192
69	EPHB2	0.68424898
70	NLK	0.68393245
71	TESK2	0.62144842
72	MINK1	0.61410024
73	RPS6KA4	0.60559076
74	MAPKAPK3	0.60078294
75	STK39	0.59905682
76	PRKCG	0.59604475
77	MAPKAPK5	0.55984481
78	FGFR1	0.52306878
79	CSNK1A1	0.48154710
80	STK24	0.45713495
81	DAPK1	0.42610520
82	PDK2	0.42039712
83	CAMKK2	0.39821711
84	DYRK1A	0.39338407
85	CSNK2A1	0.37543982
86	TGFBR1	0.35035056
87	ATR	0.34998401
88	CDK3	0.34739192
89	PRKCI	0.33591643
90	ACVR1B	0.32961957
91	CAMK2A	0.31709174
92	AURKB	0.27636556
93	BMPR2	0.26876111
94	FGFR2	0.26299707
95	CSNK2A2	0.26040173
96	PRKACA	0.25997593
97	STK3	0.25748274
98	EPHB1	0.25623181
99	PTK2B	0.25592317
100	TIE1	0.25362535

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.21082116
2	Protein export_Homo sapiens_hsa03060	2.74815775
3	Proteasome_Homo sapiens_hsa03050	2.53548804
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.49324916
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48807217
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.33031712
7	Fatty acid elongation_Homo sapiens_hsa00062	2.20432283
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.08871557
9	Butanoate metabolism_Homo sapiens_hsa00650	2.07913962
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05164226
11	Parkinsons disease_Homo sapiens_hsa05012	2.01418133
12	Propanoate metabolism_Homo sapiens_hsa00640	1.95519017
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.94712399
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.85588105
15	Huntingtons disease_Homo sapiens_hsa05016	1.78872959
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.76862391
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70960462
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.70338596
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68180752
20	beta-Alanine metabolism_Homo sapiens_hsa00410	1.66066327
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.65708290
22	Mismatch repair_Homo sapiens_hsa03430	1.57269962
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54092356
24	Peroxisome_Homo sapiens_hsa04146	1.53418087
25	Glutathione metabolism_Homo sapiens_hsa00480	1.48491363
26	Caffeine metabolism_Homo sapiens_hsa00232	1.42834551
27	Histidine metabolism_Homo sapiens_hsa00340	1.41039037
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.40803167
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.39163344
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38473637
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.36569707
32	Retinol metabolism_Homo sapiens_hsa00830	1.36308510
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.34912783
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.34055592
35	RNA polymerase_Homo sapiens_hsa03020	1.33914391
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.33297082
37	Homologous recombination_Homo sapiens_hsa03440	1.32208433
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.31385820
39	Fatty acid degradation_Homo sapiens_hsa00071	1.30687329
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27007217
41	Base excision repair_Homo sapiens_hsa03410	1.24015382
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20328308
43	Alzheimers disease_Homo sapiens_hsa05010	1.19020171
44	Folate biosynthesis_Homo sapiens_hsa00790	1.18952935
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13943225
46	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10484390
47	RNA degradation_Homo sapiens_hsa03018	1.04890122
48	Non-homologous end-joining_Homo sapiens_hsa03450	1.04870923
49	Fatty acid metabolism_Homo sapiens_hsa01212	1.03941378
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02664808
51	Metabolic pathways_Homo sapiens_hsa01100	0.96256295
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93774424
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.93473742
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93113416
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.91424117
56	Basal transcription factors_Homo sapiens_hsa03022	0.91265882
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.90915597
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.90850813
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.88760349
60	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.88515254
61	Carbon metabolism_Homo sapiens_hsa01200	0.87020308
62	Ribosome_Homo sapiens_hsa03010	0.85614079
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83731732
64	Phototransduction_Homo sapiens_hsa04744	0.83036579
65	Spliceosome_Homo sapiens_hsa03040	0.82476401
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80426796
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77909291
68	DNA replication_Homo sapiens_hsa03030	0.77401672
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.73506012
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72356979
71	Regulation of autophagy_Homo sapiens_hsa04140	0.71990730
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69384670
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68116987
74	Sulfur metabolism_Homo sapiens_hsa00920	0.67271373
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66998544
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66577967
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.66471838
78	RNA transport_Homo sapiens_hsa03013	0.66097805
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65418747
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64723859
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.64248336
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62724495
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.61181398
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.59154525
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59042093
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.57262988
87	Purine metabolism_Homo sapiens_hsa00230	0.56988681
88	Nicotine addiction_Homo sapiens_hsa05033	0.54669758
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.54168375
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.53348370
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53065811
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52902818
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52765881
94	Circadian rhythm_Homo sapiens_hsa04710	0.51909314
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51721771
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49788514
97	Sulfur relay system_Homo sapiens_hsa04122	0.46863032
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40852837
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38223480
100	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36885721

TMEM254

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »