

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neurofilament cytoskeleton organization (GO:0060052) | 5.92246977 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 5.71033771 |
| 3 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.25760572 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.96127730 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.82270915 |
| 6 | synaptic vesicle maturation (GO:0016188) | 4.71665522 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 4.70401432 |
| 8 | locomotory exploration behavior (GO:0035641) | 4.51802018 |
| 9 | vocalization behavior (GO:0071625) | 4.39414801 |
| 10 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 4.21747137 |
| 11 | C4-dicarboxylate transport (GO:0015740) | 4.21651769 |
| 12 | neurotransmitter secretion (GO:0007269) | 4.16029811 |
| 13 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.15020233 |
| 14 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.09384436 |
| 15 | dopamine biosynthetic process (GO:0042416) | 4.06822710 |
| 16 | glutamate secretion (GO:0014047) | 4.06284412 |
| 17 | mating behavior (GO:0007617) | 4.05398909 |
| 18 | retinal ganglion cell axon guidance (GO:0031290) | 4.03668778 |
| 19 | nucleobase catabolic process (GO:0046113) | 4.02033637 |
| 20 | proline transport (GO:0015824) | 4.01266090 |
| 21 | neuromuscular process controlling posture (GO:0050884) | 3.98002095 |
| 22 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.95706818 |
| 23 | dopamine transport (GO:0015872) | 3.91688520 |
| 24 | exploration behavior (GO:0035640) | 3.91325142 |
| 25 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.90139175 |
| 26 | protein localization to synapse (GO:0035418) | 3.86068624 |
| 27 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.85431458 |
| 28 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.83545347 |
| 29 | neurotransmitter catabolic process (GO:0042135) | 3.79357358 |
| 30 | axon extension involved in axon guidance (GO:0048846) | 3.78835538 |
| 31 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.78835538 |
| 32 | neurotransmitter transport (GO:0006836) | 3.77340764 |
| 33 | regulation of synaptic vesicle transport (GO:1902803) | 3.73102128 |
| 34 | mechanosensory behavior (GO:0007638) | 3.71431497 |
| 35 | prepulse inhibition (GO:0060134) | 3.70089443 |
| 36 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.66998535 |
| 37 | neuron recognition (GO:0008038) | 3.66032175 |
| 38 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.65003529 |
| 39 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.61619263 |
| 40 | transmission of nerve impulse (GO:0019226) | 3.61195673 |
| 41 | neuronal action potential propagation (GO:0019227) | 3.60892266 |
| 42 | regulation of neurotransmitter levels (GO:0001505) | 3.60550852 |
| 43 | sodium ion export (GO:0071436) | 3.58278701 |
| 44 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.55585862 |
| 45 | positive regulation of synapse assembly (GO:0051965) | 3.53837240 |
| 46 | catecholamine transport (GO:0051937) | 3.52306253 |
| 47 | regulation of respiratory system process (GO:0044065) | 3.51614432 |
| 48 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.50758595 |
| 49 | establishment of mitochondrion localization (GO:0051654) | 3.50579094 |
| 50 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.50344561 |
| 51 | regulation of protein kinase A signaling (GO:0010738) | 3.48589685 |
| 52 | neuron-neuron synaptic transmission (GO:0007270) | 3.47358131 |
| 53 | regulation of dopamine metabolic process (GO:0042053) | 3.44008066 |
| 54 | regulation of catecholamine metabolic process (GO:0042069) | 3.44008066 |
| 55 | presynaptic membrane assembly (GO:0097105) | 3.41950357 |
| 56 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.41494498 |
| 57 | glutamate receptor signaling pathway (GO:0007215) | 3.41066884 |
| 58 | synaptic transmission, cholinergic (GO:0007271) | 3.40954328 |
| 59 | synaptic transmission, glutamatergic (GO:0035249) | 3.35486856 |
| 60 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.34592611 |
| 61 | response to histamine (GO:0034776) | 3.32694958 |
| 62 | presynaptic membrane organization (GO:0097090) | 3.31934098 |
| 63 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.30705233 |
| 64 | activation of protein kinase A activity (GO:0034199) | 3.26783834 |
| 65 | negative regulation of neurotransmitter transport (GO:0051589) | 3.25060589 |
| 66 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.24448359 |
| 67 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.24006355 |
| 68 | layer formation in cerebral cortex (GO:0021819) | 3.23413290 |
| 69 | axon regeneration (GO:0031103) | 3.21768306 |
| 70 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.20634265 |
| 71 | membrane depolarization during action potential (GO:0086010) | 3.19694531 |
| 72 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.19583842 |
| 73 | axonal fasciculation (GO:0007413) | 3.19519498 |
| 74 | cellular potassium ion homeostasis (GO:0030007) | 3.19374875 |
| 75 | gamma-aminobutyric acid transport (GO:0015812) | 3.18531111 |
| 76 | synaptic vesicle endocytosis (GO:0048488) | 3.18225106 |
| 77 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.15939421 |
| 78 | dendrite morphogenesis (GO:0048813) | 3.13184843 |
| 79 | response to manganese ion (GO:0010042) | 3.12808552 |
| 80 | postsynaptic membrane organization (GO:0001941) | 3.11473508 |
| 81 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.10799335 |
| 82 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.10168194 |
| 83 | synapse assembly (GO:0007416) | 3.09273127 |
| 84 | regulation of transmission of nerve impulse (GO:0051969) | 3.06895757 |
| 85 | axon extension (GO:0048675) | 3.06624360 |
| 86 | regulation of vesicle fusion (GO:0031338) | 3.06493785 |
| 87 | neuron projection regeneration (GO:0031102) | 3.05679162 |
| 88 | membrane hyperpolarization (GO:0060081) | 3.04230135 |
| 89 | astrocyte differentiation (GO:0048708) | 3.02842185 |
| 90 | intraspecies interaction between organisms (GO:0051703) | 3.02665433 |
| 91 | social behavior (GO:0035176) | 3.02665433 |
| 92 | regulation of heat generation (GO:0031650) | 3.02647940 |
| 93 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.99932622 |
| 94 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.99041057 |
| 95 | phenol-containing compound catabolic process (GO:0019336) | 2.97181531 |
| 96 | regulation of synapse structural plasticity (GO:0051823) | 2.96386810 |
| 97 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.96294798 |
| 98 | innervation (GO:0060384) | 2.96174950 |
| 99 | long-term memory (GO:0007616) | 2.95314501 |
| 100 | behavioral response to cocaine (GO:0048148) | 2.95053269 |
| 101 | regulation of glutamate secretion (GO:0014048) | 2.94563559 |
| 102 | righting reflex (GO:0060013) | 2.92032633 |
| 103 | alkaloid metabolic process (GO:0009820) | 2.91888743 |
| 104 | catechol-containing compound biosynthetic process (GO:0009713) | 2.91752913 |
| 105 | catecholamine biosynthetic process (GO:0042423) | 2.91752913 |
| 106 | neurotransmitter uptake (GO:0001504) | 2.91181338 |
| 107 | cellular sodium ion homeostasis (GO:0006883) | 2.89414958 |
| 108 | opioid receptor signaling pathway (GO:0038003) | 2.89189761 |
| 109 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.88604329 |
| 110 | membrane depolarization (GO:0051899) | 2.87867825 |
| 111 | neuronal action potential (GO:0019228) | 2.86648568 |
| 112 | neurotransmitter biosynthetic process (GO:0042136) | 2.86425391 |
| 113 | acidic amino acid transport (GO:0015800) | 2.84653063 |
| 114 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.84652524 |
| 115 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.84551902 |
| 116 | neurotransmitter metabolic process (GO:0042133) | 2.84501700 |
| 117 | establishment of synaptic vesicle localization (GO:0097480) | 2.84421345 |
| 118 | synaptic vesicle transport (GO:0048489) | 2.84421345 |
| 119 | potassium ion import (GO:0010107) | 2.84355806 |
| 120 | regulation of fever generation (GO:0031620) | 2.84344843 |
| 121 | regulation of postsynaptic membrane potential (GO:0060078) | 2.84167370 |
| 122 | synapse organization (GO:0050808) | 2.83268896 |
| 123 | auditory behavior (GO:0031223) | 2.82348802 |
| 124 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.81001067 |
| 125 | response to cocaine (GO:0042220) | 2.79990468 |
| 126 | adult walking behavior (GO:0007628) | 2.79700191 |
| 127 | neuronal ion channel clustering (GO:0045161) | 2.78584013 |
| 128 | cell communication by electrical coupling (GO:0010644) | 2.78488381 |
| 129 | regulation of neurotransmitter uptake (GO:0051580) | 2.78314143 |
| 130 | axon development (GO:0061564) | 2.78170592 |
| 131 | regulation of synapse assembly (GO:0051963) | 2.77776552 |
| 132 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.77604827 |
| 133 | synaptic transmission (GO:0007268) | 2.77223329 |
| 134 | response to auditory stimulus (GO:0010996) | 2.77121988 |
| 135 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.76581764 |
| 136 | positive regulation of amino acid transport (GO:0051957) | 2.76004615 |
| 137 | dendritic spine morphogenesis (GO:0060997) | 2.74922194 |
| 138 | protein localization to cilium (GO:0061512) | 2.74877218 |
| 139 | negative regulation of synaptic transmission (GO:0050805) | 2.74561056 |
| 140 | vesicle transport along microtubule (GO:0047496) | 2.72790088 |
| 141 | regulation of neurotransmitter secretion (GO:0046928) | 2.71988632 |
| 142 | regulation of penile erection (GO:0060405) | 2.69689015 |
| 143 | mitochondrion transport along microtubule (GO:0047497) | 2.69684789 |
| 144 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.69684789 |
| 145 | short-term memory (GO:0007614) | 2.67058286 |
| 146 | ganglion development (GO:0061548) | 2.63557808 |
| 147 | regulation of respiratory gaseous exchange (GO:0043576) | 2.63100318 |
| 148 | L-glutamate transport (GO:0015813) | 2.59733380 |
| 149 | intermediate filament organization (GO:0045109) | 2.59319735 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.73536624 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.51069979 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.16512072 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.09213002 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.99152154 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.72924623 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.67096983 |
| 8 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.66036155 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.63434214 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.63434214 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.58708752 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.55264562 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.54029965 |
| 14 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.53672527 |
| 15 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.46485265 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43855824 |
| 17 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.38959431 |
| 18 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.37285755 |
| 19 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.30439488 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.19992807 |
| 21 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.12012659 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.10417605 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.06587116 |
| 24 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.05592186 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.05272717 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.98559325 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.96563730 |
| 28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.96202524 |
| 29 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.95576103 |
| 30 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.90241605 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.87097221 |
| 32 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.86188066 |
| 33 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.85290462 |
| 34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.84066428 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.74602186 |
| 36 | P300_19829295_ChIP-Seq_ESCs_Human | 1.66042109 |
| 37 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.61619113 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.60980392 |
| 39 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.58791036 |
| 40 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.57109920 |
| 41 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.51112631 |
| 42 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.51054157 |
| 43 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.50982795 |
| 44 | VDR_22108803_ChIP-Seq_LS180_Human | 1.49844417 |
| 45 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.49103720 |
| 46 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.48883088 |
| 47 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.48587879 |
| 48 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.44506924 |
| 49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.42709275 |
| 50 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.42433389 |
| 51 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.42181851 |
| 52 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.42007877 |
| 53 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.39339720 |
| 54 | EWS_26573619_Chip-Seq_HEK293_Human | 1.37081839 |
| 55 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.36883466 |
| 56 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.33129961 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30773089 |
| 58 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.26811081 |
| 59 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.24523251 |
| 60 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.24048734 |
| 61 | AR_25329375_ChIP-Seq_VCAP_Human | 1.23815954 |
| 62 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.23777218 |
| 63 | STAT3_23295773_ChIP-Seq_U87_Human | 1.21573371 |
| 64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21529344 |
| 65 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.19907871 |
| 66 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.19861811 |
| 67 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19830154 |
| 68 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.17444109 |
| 69 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.16430494 |
| 70 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.14764267 |
| 71 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.14509073 |
| 72 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.13926499 |
| 73 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.13473340 |
| 74 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.13168811 |
| 75 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10660447 |
| 76 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10274479 |
| 77 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.10265104 |
| 78 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.09775921 |
| 79 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.08949139 |
| 80 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.07579194 |
| 81 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.07579194 |
| 82 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.06720508 |
| 83 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.05972243 |
| 84 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04982019 |
| 85 | TCF4_23295773_ChIP-Seq_U87_Human | 1.04826790 |
| 86 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04810361 |
| 87 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.04699322 |
| 88 | JUN_21703547_ChIP-Seq_K562_Human | 1.04395011 |
| 89 | AR_19668381_ChIP-Seq_PC3_Human | 1.04346060 |
| 90 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.03506469 |
| 91 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.02181626 |
| 92 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.01957973 |
| 93 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.01527090 |
| 94 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.00570286 |
| 95 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.00173063 |
| 96 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.97977853 |
| 97 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.97078917 |
| 98 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.96735757 |
| 99 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.96439569 |
| 100 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96254495 |
| 101 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.95931303 |
| 102 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95913757 |
| 103 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.94993107 |
| 104 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.94296738 |
| 105 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.93992197 |
| 106 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.93456760 |
| 107 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.93164336 |
| 108 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.92327178 |
| 109 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.90893331 |
| 110 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90832553 |
| 111 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.90022345 |
| 112 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.89317235 |
| 113 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.89314789 |
| 114 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88628942 |
| 115 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.88628942 |
| 116 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.87424386 |
| 117 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.86954331 |
| 118 | KDM2B_26808549_Chip-Seq_REH_Human | 0.86362190 |
| 119 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.85943321 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.77475952 |
| 2 | MP0006276_abnormal_autonomic_nervous | 4.24053336 |
| 3 | MP0003122_maternal_imprinting | 4.13952283 |
| 4 | MP0001968_abnormal_touch/_nociception | 3.81419154 |
| 5 | MP0004859_abnormal_synaptic_plasticity | 3.79701038 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 3.33313075 |
| 7 | MP0002736_abnormal_nociception_after | 3.30765984 |
| 8 | MP0003136_yellow_coat_color | 3.17118065 |
| 9 | MP0009046_muscle_twitch | 2.99152165 |
| 10 | MP0002735_abnormal_chemical_nociception | 2.94163961 |
| 11 | MP0005423_abnormal_somatic_nervous | 2.86638636 |
| 12 | MP0009745_abnormal_behavioral_response | 2.85763132 |
| 13 | MP0002064_seizures | 2.72483611 |
| 14 | MP0005645_abnormal_hypothalamus_physiol | 2.70609188 |
| 15 | MP0004270_analgesia | 2.64560334 |
| 16 | MP0002734_abnormal_mechanical_nocicepti | 2.60549592 |
| 17 | MP0002272_abnormal_nervous_system | 2.54029103 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.51559834 |
| 19 | MP0002063_abnormal_learning/memory/cond | 2.49186660 |
| 20 | MP0002572_abnormal_emotion/affect_behav | 2.49093100 |
| 21 | MP0001905_abnormal_dopamine_level | 2.36968670 |
| 22 | MP0002733_abnormal_thermal_nociception | 2.36888978 |
| 23 | MP0001529_abnormal_vocalization | 2.16880372 |
| 24 | MP0001970_abnormal_pain_threshold | 2.13306507 |
| 25 | MP0005248_abnormal_Harderian_gland | 2.12256988 |
| 26 | MP0002067_abnormal_sensory_capabilities | 2.10413767 |
| 27 | MP0005646_abnormal_pituitary_gland | 2.06218161 |
| 28 | MP0001440_abnormal_grooming_behavior | 2.04749300 |
| 29 | MP0003011_delayed_dark_adaptation | 2.04489501 |
| 30 | MP0001486_abnormal_startle_reflex | 2.02685366 |
| 31 | MP0002184_abnormal_innervation | 1.87905112 |
| 32 | MP0004924_abnormal_behavior | 1.83148101 |
| 33 | MP0005386_behavior/neurological_phenoty | 1.83148101 |
| 34 | MP0004142_abnormal_muscle_tone | 1.82668918 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.78892494 |
| 36 | MP0002102_abnormal_ear_morphology | 1.71052926 |
| 37 | MP0001188_hyperpigmentation | 1.67145573 |
| 38 | MP0000566_synostosis | 1.62738889 |
| 39 | MP0005253_abnormal_eye_physiology | 1.56974341 |
| 40 | MP0005409_darkened_coat_color | 1.56873577 |
| 41 | MP0001984_abnormal_olfaction | 1.55660824 |
| 42 | MP0003121_genomic_imprinting | 1.55473128 |
| 43 | MP0000778_abnormal_nervous_system | 1.50169158 |
| 44 | MP0002909_abnormal_adrenal_gland | 1.49055892 |
| 45 | MP0004858_abnormal_nervous_system | 1.47991720 |
| 46 | MP0003787_abnormal_imprinting | 1.43395600 |
| 47 | MP0003123_paternal_imprinting | 1.41277629 |
| 48 | MP0000955_abnormal_spinal_cord | 1.40299569 |
| 49 | MP0008569_lethality_at_weaning | 1.34740623 |
| 50 | MP0004811_abnormal_neuron_physiology | 1.33997827 |
| 51 | MP0001502_abnormal_circadian_rhythm | 1.31063746 |
| 52 | MP0002882_abnormal_neuron_morphology | 1.28646046 |
| 53 | MP0002066_abnormal_motor_capabilities/c | 1.27654268 |
| 54 | MP0002653_abnormal_ependyma_morphology | 1.19576922 |
| 55 | MP0009780_abnormal_chondrocyte_physiolo | 1.15984217 |
| 56 | MP0003329_amyloid_beta_deposits | 1.12837104 |
| 57 | MP0002090_abnormal_vision | 1.12711640 |
| 58 | MP0001986_abnormal_taste_sensitivity | 1.11878416 |
| 59 | MP0000026_abnormal_inner_ear | 1.10165463 |
| 60 | MP0000751_myopathy | 1.09109660 |
| 61 | MP0005535_abnormal_body_temperature | 1.06601077 |
| 62 | MP0004145_abnormal_muscle_electrophysio | 1.06549161 |
| 63 | MP0008872_abnormal_physiological_respon | 1.01535443 |
| 64 | MP0000631_abnormal_neuroendocrine_gland | 0.98768159 |
| 65 | MP0002332_abnormal_exercise_endurance | 0.98406199 |
| 66 | MP0002822_catalepsy | 0.97160118 |
| 67 | MP0004742_abnormal_vestibular_system | 0.95960003 |
| 68 | MP0003633_abnormal_nervous_system | 0.93346294 |
| 69 | MP0005187_abnormal_penis_morphology | 0.93268347 |
| 70 | MP0004043_abnormal_pH_regulation | 0.91669557 |
| 71 | MP0005171_absent_coat_pigmentation | 0.91249379 |
| 72 | MP0002152_abnormal_brain_morphology | 0.87217069 |
| 73 | MP0010386_abnormal_urinary_bladder | 0.87107664 |
| 74 | MP0003283_abnormal_digestive_organ | 0.86541848 |
| 75 | MP0000604_amyloidosis | 0.86271086 |
| 76 | MP0003137_abnormal_impulse_conducting | 0.86060783 |
| 77 | MP0002229_neurodegeneration | 0.84971869 |
| 78 | MP0004885_abnormal_endolymph | 0.84362706 |
| 79 | MP0003634_abnormal_glial_cell | 0.84294930 |
| 80 | MP0005174_abnormal_tail_pigmentation | 0.83521514 |
| 81 | MP0003631_nervous_system_phenotype | 0.83219467 |
| 82 | MP0002751_abnormal_autonomic_nervous | 0.82883444 |
| 83 | MP0006072_abnormal_retinal_apoptosis | 0.82717955 |
| 84 | MP0001664_abnormal_digestion | 0.82675542 |
| 85 | MP0004085_abnormal_heartbeat | 0.82452513 |
| 86 | MP0002139_abnormal_hepatobiliary_system | 0.81907056 |
| 87 | MP0005167_abnormal_blood-brain_barrier | 0.78588688 |
| 88 | MP0005391_vision/eye_phenotype | 0.78337606 |
| 89 | MP0002837_dystrophic_cardiac_calcinosis | 0.78055202 |
| 90 | MP0002752_abnormal_somatic_nervous | 0.76192007 |
| 91 | MP0000013_abnormal_adipose_tissue | 0.75757373 |
| 92 | MP0003861_abnormal_nervous_system | 0.75464380 |
| 93 | MP0001943_abnormal_respiration | 0.74344529 |
| 94 | MP0005595_abnormal_vascular_smooth | 0.74272717 |
| 95 | MP0001324_abnormal_eye_pigmentation | 0.73951848 |
| 96 | MP0008877_abnormal_DNA_methylation | 0.72403524 |
| 97 | MP0009379_abnormal_foot_pigmentation | 0.71899541 |
| 98 | MP0002069_abnormal_eating/drinking_beha | 0.71647766 |
| 99 | MP0003879_abnormal_hair_cell | 0.71608439 |
| 100 | MP0005551_abnormal_eye_electrophysiolog | 0.71098651 |
| 101 | MP0000920_abnormal_myelination | 0.71009098 |
| 102 | MP0005195_abnormal_posterior_eye | 0.71007916 |
| 103 | MP0002234_abnormal_pharynx_morphology | 0.70949285 |
| 104 | MP0000639_abnormal_adrenal_gland | 0.70642262 |
| 105 | MP0001963_abnormal_hearing_physiology | 0.70560831 |
| 106 | MP0003690_abnormal_glial_cell | 0.70270903 |
| 107 | MP0004215_abnormal_myocardial_fiber | 0.68947178 |
| 108 | MP0005379_endocrine/exocrine_gland_phen | 0.68055858 |
| 109 | MP0001299_abnormal_eye_distance/ | 0.67647016 |
| 110 | MP0005623_abnormal_meninges_morphology | 0.66329933 |
| 111 | MP0002638_abnormal_pupillary_reflex | 0.65629427 |
| 112 | MP0002095_abnormal_skin_pigmentation | 0.65395188 |
| 113 | MP0000569_abnormal_digit_pigmentation | 0.65047510 |
| 114 | MP0000538_abnormal_urinary_bladder | 0.64842460 |
| 115 | MP0004133_heterotaxia | 0.62432605 |
| 116 | MP0003632_abnormal_nervous_system | 0.60298678 |
| 117 | MP0001177_atelectasis | 0.59845059 |
| 118 | MP0008874_decreased_physiological_sensi | 0.59472371 |
| 119 | MP0002163_abnormal_gland_morphology | 0.59110095 |
| 120 | MP0002876_abnormal_thyroid_physiology | 0.58580937 |
| 121 | MP0001485_abnormal_pinna_reflex | 0.58461456 |
| 122 | MP0005394_taste/olfaction_phenotype | 0.57305102 |
| 123 | MP0005499_abnormal_olfactory_system | 0.57305102 |
| 124 | MP0000747_muscle_weakness | 0.56488970 |
| 125 | MP0000534_abnormal_ureter_morphology | 0.55957511 |
| 126 | MP0000462_abnormal_digestive_system | 0.55583687 |
| 127 | MP0008260_abnormal_autophagy | 0.54942351 |
| 128 | MP0005410_abnormal_fertilization | 0.53421393 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Limb dystonia (HP:0002451) | 5.94821934 |
| 2 | Focal motor seizures (HP:0011153) | 5.58366594 |
| 3 | Visual hallucinations (HP:0002367) | 5.20778834 |
| 4 | Myokymia (HP:0002411) | 4.92653476 |
| 5 | Focal seizures (HP:0007359) | 4.66033855 |
| 6 | Pheochromocytoma (HP:0002666) | 4.35290185 |
| 7 | Atonic seizures (HP:0010819) | 4.31276423 |
| 8 | Failure to thrive in infancy (HP:0001531) | 4.13370181 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.07163533 |
| 10 | Absence seizures (HP:0002121) | 3.88446324 |
| 11 | Neuroendocrine neoplasm (HP:0100634) | 3.87967522 |
| 12 | Septo-optic dysplasia (HP:0100842) | 3.78409143 |
| 13 | Split foot (HP:0001839) | 3.75039628 |
| 14 | Febrile seizures (HP:0002373) | 3.66923537 |
| 15 | Hemiplegia (HP:0002301) | 3.60962056 |
| 16 | Dialeptic seizures (HP:0011146) | 3.43963307 |
| 17 | Generalized tonic-clonic seizures (HP:0002069) | 3.36227930 |
| 18 | Hypothermia (HP:0002045) | 3.34643288 |
| 19 | Supranuclear gaze palsy (HP:0000605) | 3.28991245 |
| 20 | Akinesia (HP:0002304) | 3.20960249 |
| 21 | Epileptic encephalopathy (HP:0200134) | 3.19755892 |
| 22 | Action tremor (HP:0002345) | 3.05966332 |
| 23 | Neurofibrillary tangles (HP:0002185) | 3.04734480 |
| 24 | Hypoventilation (HP:0002791) | 3.02778364 |
| 25 | Abnormal eating behavior (HP:0100738) | 2.99611716 |
| 26 | Mutism (HP:0002300) | 2.98233533 |
| 27 | Polyphagia (HP:0002591) | 2.95060446 |
| 28 | Papilledema (HP:0001085) | 2.91002193 |
| 29 | Progressive inability to walk (HP:0002505) | 2.90700730 |
| 30 | Abnormal hair whorl (HP:0010721) | 2.89861514 |
| 31 | Anxiety (HP:0000739) | 2.83000306 |
| 32 | Ankle clonus (HP:0011448) | 2.79687975 |
| 33 | Optic nerve hypoplasia (HP:0000609) | 2.78928379 |
| 34 | Cortical dysplasia (HP:0002539) | 2.78408799 |
| 35 | Ulnar claw (HP:0001178) | 2.75038123 |
| 36 | Truncal ataxia (HP:0002078) | 2.73543610 |
| 37 | Insidious onset (HP:0003587) | 2.69795495 |
| 38 | Termporal pattern (HP:0011008) | 2.69795495 |
| 39 | Megalencephaly (HP:0001355) | 2.69056552 |
| 40 | Agitation (HP:0000713) | 2.68204465 |
| 41 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.68112091 |
| 42 | Abnormality of the corticospinal tract (HP:0002492) | 2.67092618 |
| 43 | Inability to walk (HP:0002540) | 2.64089552 |
| 44 | Diminished movement (HP:0002374) | 2.64061923 |
| 45 | Diplopia (HP:0000651) | 2.58709079 |
| 46 | Abnormality of binocular vision (HP:0011514) | 2.58709079 |
| 47 | Broad foot (HP:0001769) | 2.55770250 |
| 48 | Status epilepticus (HP:0002133) | 2.55716825 |
| 49 | Depression (HP:0000716) | 2.49798239 |
| 50 | Hyperthyroidism (HP:0000836) | 2.46181002 |
| 51 | Hypokinesia (HP:0002375) | 2.45040720 |
| 52 | Narrow nasal bridge (HP:0000446) | 2.41765776 |
| 53 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.40507979 |
| 54 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.39477391 |
| 55 | Alacrima (HP:0000522) | 2.37086545 |
| 56 | Urinary urgency (HP:0000012) | 2.35209186 |
| 57 | Broad-based gait (HP:0002136) | 2.32995674 |
| 58 | Postural tremor (HP:0002174) | 2.32268096 |
| 59 | Abnormal ciliary motility (HP:0012262) | 2.28287052 |
| 60 | Drooling (HP:0002307) | 2.27727707 |
| 61 | Excessive salivation (HP:0003781) | 2.27727707 |
| 62 | Aplasia involving bones of the extremities (HP:0009825) | 2.26096349 |
| 63 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.26096349 |
| 64 | Aplasia of the phalanges of the hand (HP:0009802) | 2.26096349 |
| 65 | Dyskinesia (HP:0100660) | 2.25580864 |
| 66 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.25342692 |
| 67 | Gait imbalance (HP:0002141) | 2.25251233 |
| 68 | Genital tract atresia (HP:0001827) | 2.25242337 |
| 69 | Abnormality of pain sensation (HP:0010832) | 2.25164305 |
| 70 | Impaired pain sensation (HP:0007328) | 2.25164305 |
| 71 | Dysmetria (HP:0001310) | 2.23509675 |
| 72 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.21375999 |
| 73 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.21375999 |
| 74 | Vaginal atresia (HP:0000148) | 2.19973688 |
| 75 | Postural instability (HP:0002172) | 2.19725408 |
| 76 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.19549878 |
| 77 | Absent/shortened dynein arms (HP:0200106) | 2.19549878 |
| 78 | Peripheral hypomyelination (HP:0007182) | 2.19478987 |
| 79 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.18514343 |
| 80 | Hammertoe (HP:0001765) | 2.18457637 |
| 81 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.17800982 |
| 82 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.17503579 |
| 83 | Hyperventilation (HP:0002883) | 2.17190360 |
| 84 | Spastic gait (HP:0002064) | 2.16547887 |
| 85 | Decreased lacrimation (HP:0000633) | 2.16110994 |
| 86 | Retinal dysplasia (HP:0007973) | 2.14752559 |
| 87 | Absent septum pellucidum (HP:0001331) | 2.14472387 |
| 88 | Lower limb muscle weakness (HP:0007340) | 2.13837851 |
| 89 | Psychosis (HP:0000709) | 2.13657391 |
| 90 | Specific learning disability (HP:0001328) | 2.13203355 |
| 91 | Hypercortisolism (HP:0001578) | 2.11755547 |
| 92 | Abnormality of midbrain morphology (HP:0002418) | 2.10703105 |
| 93 | Molar tooth sign on MRI (HP:0002419) | 2.10703105 |
| 94 | Steppage gait (HP:0003376) | 2.09758637 |
| 95 | Esotropia (HP:0000565) | 2.09476137 |
| 96 | Fetal akinesia sequence (HP:0001989) | 2.08060305 |
| 97 | Ventricular fibrillation (HP:0001663) | 2.06131396 |
| 98 | Large for gestational age (HP:0001520) | 2.04297349 |
| 99 | Bradykinesia (HP:0002067) | 2.02077504 |
| 100 | Congenital primary aphakia (HP:0007707) | 2.01561123 |
| 101 | Delayed gross motor development (HP:0002194) | 2.01375294 |
| 102 | Poor suck (HP:0002033) | 2.00231093 |
| 103 | Abnormal pupillary function (HP:0007686) | 1.98931662 |
| 104 | Cerebral hemorrhage (HP:0001342) | 1.98893463 |
| 105 | Scanning speech (HP:0002168) | 1.98461963 |
| 106 | Coronal craniosynostosis (HP:0004440) | 1.97845926 |
| 107 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.97781524 |
| 108 | Amblyopia (HP:0000646) | 1.97779251 |
| 109 | Spastic tetraplegia (HP:0002510) | 1.97459754 |
| 110 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.97048611 |
| 111 | Gaze-evoked nystagmus (HP:0000640) | 1.96913310 |
| 112 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.94564802 |
| 113 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.94564802 |
| 114 | Potter facies (HP:0002009) | 1.94204461 |
| 115 | Facial shape deformation (HP:0011334) | 1.94204461 |
| 116 | Progressive macrocephaly (HP:0004481) | 1.92775602 |
| 117 | Abnormality of salivation (HP:0100755) | 1.91543301 |
| 118 | Dysdiadochokinesis (HP:0002075) | 1.91429934 |
| 119 | Acute necrotizing encephalopathy (HP:0006965) | 1.90237020 |
| 120 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 1.88590255 |
| 121 | Turricephaly (HP:0000262) | 1.87206750 |
| 122 | Poor eye contact (HP:0000817) | 1.86710964 |
| 123 | Hemiparesis (HP:0001269) | 1.86020978 |
| 124 | Medial flaring of the eyebrow (HP:0010747) | 1.85841928 |
| 125 | Torticollis (HP:0000473) | 1.85778487 |
| 126 | Abnormality of glycolipid metabolism (HP:0010969) | 1.85639322 |
| 127 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.85639322 |
| 128 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.85639322 |
| 129 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.85558857 |
| 130 | Oligomenorrhea (HP:0000876) | 1.85491729 |
| 131 | Cerebral inclusion bodies (HP:0100314) | 1.84981538 |
| 132 | Abnormal EKG (HP:0003115) | 1.84715651 |
| 133 | Amyotrophic lateral sclerosis (HP:0007354) | 1.84236431 |
| 134 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.80340573 |
| 135 | Generalized myoclonic seizures (HP:0002123) | 1.79681748 |
| 136 | Blue irides (HP:0000635) | 1.79636533 |
| 137 | Sleep apnea (HP:0010535) | 1.79198973 |
| 138 | Neuronal loss in central nervous system (HP:0002529) | 1.79135978 |
| 139 | Exercise-induced muscle cramps (HP:0003710) | 1.78871301 |
| 140 | Rapidly progressive (HP:0003678) | 1.77988397 |
| 141 | Abnormality of the antihelix (HP:0009738) | 1.77836054 |
| 142 | Nephrogenic diabetes insipidus (HP:0009806) | 1.77454350 |
| 143 | Genetic anticipation (HP:0003743) | 1.77366320 |
| 144 | Oligodactyly (hands) (HP:0001180) | 1.74684554 |
| 145 | Large earlobe (HP:0009748) | 1.70431638 |
| 146 | Nuclear cataract (HP:0100018) | 1.67906847 |
| 147 | Muscular hypotonia of the trunk (HP:0008936) | 1.67457600 |
| 148 | Hepatoblastoma (HP:0002884) | 1.67220722 |
| 149 | Short foot (HP:0001773) | 1.65244423 |
| 150 | Abnormality of the diencephalon (HP:0010662) | 1.64848334 |
| 151 | Long nose (HP:0003189) | 1.64753573 |
| 152 | Myoclonus (HP:0001336) | 1.61399984 |
| 153 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.60570624 |
| 154 | Pachygyria (HP:0001302) | 1.60517045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.90396009 |
| 2 | MAP3K12 | 4.13235164 |
| 3 | MAP3K9 | 3.22296921 |
| 4 | EPHA3 | 3.13180644 |
| 5 | MAP3K4 | 2.94964098 |
| 6 | MINK1 | 2.91831717 |
| 7 | MAP2K7 | 2.66781114 |
| 8 | MAP4K2 | 2.59919016 |
| 9 | CASK | 2.45388216 |
| 10 | MARK1 | 2.45050373 |
| 11 | MAP2K4 | 2.42731378 |
| 12 | PNCK | 2.33654552 |
| 13 | ARAF | 2.10024243 |
| 14 | GRK5 | 1.98517283 |
| 15 | MAPKAPK5 | 1.92773078 |
| 16 | NTRK2 | 1.89186848 |
| 17 | DYRK2 | 1.77728276 |
| 18 | NTRK1 | 1.72055158 |
| 19 | PAK6 | 1.65109500 |
| 20 | KSR2 | 1.64485298 |
| 21 | BCKDK | 1.60506800 |
| 22 | PLK2 | 1.60496920 |
| 23 | LATS2 | 1.49066402 |
| 24 | CSNK1G2 | 1.48596770 |
| 25 | CSNK1G3 | 1.45051104 |
| 26 | UHMK1 | 1.44475012 |
| 27 | MAPK13 | 1.42261922 |
| 28 | ADRBK2 | 1.40768305 |
| 29 | CAMK2A | 1.34118674 |
| 30 | EPHB2 | 1.27384341 |
| 31 | CDK5 | 1.23723233 |
| 32 | GRK7 | 1.15856867 |
| 33 | FES | 1.15737851 |
| 34 | PKN1 | 1.13816935 |
| 35 | CAMKK2 | 1.12861934 |
| 36 | PHKG2 | 1.12133671 |
| 37 | PHKG1 | 1.12133671 |
| 38 | RET | 1.06011680 |
| 39 | PAK3 | 1.04768354 |
| 40 | PRKCG | 1.03801890 |
| 41 | LMTK2 | 1.03225136 |
| 42 | CSNK1G1 | 1.02047552 |
| 43 | FER | 0.99368086 |
| 44 | KSR1 | 0.98810117 |
| 45 | MOS | 0.98387435 |
| 46 | WNK1 | 0.96786598 |
| 47 | TNK2 | 0.96700696 |
| 48 | CAMK2G | 0.94403863 |
| 49 | LIMK1 | 0.93961806 |
| 50 | RIPK4 | 0.90730809 |
| 51 | STK39 | 0.90443836 |
| 52 | NEK9 | 0.90161481 |
| 53 | MAP3K1 | 0.89449479 |
| 54 | CDK14 | 0.89105918 |
| 55 | STK38 | 0.87879957 |
| 56 | CAMK2B | 0.87026153 |
| 57 | EPHA4 | 0.86353539 |
| 58 | ADRBK1 | 0.86070502 |
| 59 | TNIK | 0.85577576 |
| 60 | TYRO3 | 0.85400361 |
| 61 | CAMK1G | 0.83418518 |
| 62 | INSRR | 0.82458711 |
| 63 | SIK2 | 0.81814958 |
| 64 | MAP3K2 | 0.81547214 |
| 65 | SGK223 | 0.80544283 |
| 66 | SGK494 | 0.80544283 |
| 67 | CAMKK1 | 0.80282980 |
| 68 | CDK18 | 0.79270569 |
| 69 | STK16 | 0.78288028 |
| 70 | CAMK2D | 0.77461995 |
| 71 | PRKCH | 0.77223827 |
| 72 | CSNK1A1 | 0.76422476 |
| 73 | BMPR1B | 0.76039624 |
| 74 | ERBB2 | 0.75527635 |
| 75 | MAP3K13 | 0.75510950 |
| 76 | CDK15 | 0.75444630 |
| 77 | SCYL2 | 0.74148986 |
| 78 | WNK4 | 0.71881425 |
| 79 | CDK3 | 0.70788483 |
| 80 | PRKD3 | 0.70568030 |
| 81 | PRKACB | 0.70148624 |
| 82 | CDC42BPA | 0.68889341 |
| 83 | WNK3 | 0.68390656 |
| 84 | SGK2 | 0.68319988 |
| 85 | RPS6KA5 | 0.67878602 |
| 86 | DDR2 | 0.67272516 |
| 87 | TAOK3 | 0.66430556 |
| 88 | TIE1 | 0.66171053 |
| 89 | PRKCE | 0.64495288 |
| 90 | OXSR1 | 0.63617255 |
| 91 | DYRK3 | 0.63568728 |
| 92 | CDK11A | 0.63274826 |
| 93 | DYRK1A | 0.63213548 |
| 94 | CDK19 | 0.62686370 |
| 95 | PTK2B | 0.62662485 |
| 96 | CCNB1 | 0.62374144 |
| 97 | STK11 | 0.62232129 |
| 98 | BCR | 0.62062658 |
| 99 | CAMK1 | 0.58625068 |
| 100 | ERBB4 | 0.58582218 |
| 101 | CSNK1D | 0.57004164 |
| 102 | ERBB3 | 0.55664957 |
| 103 | RPS6KA2 | 0.55402069 |
| 104 | BRAF | 0.51881136 |
| 105 | PRKAA1 | 0.50000122 |
| 106 | PINK1 | 0.49561014 |
| 107 | MAPK4 | 0.48569152 |
| 108 | RPS6KA4 | 0.47368708 |
| 109 | IRAK2 | 0.47334995 |
| 110 | PRKACA | 0.47273950 |
| 111 | SGK1 | 0.46609037 |
| 112 | CSNK1A1L | 0.45593228 |
| 113 | MYLK | 0.45114949 |
| 114 | BUB1 | 0.44695356 |
| 115 | MAPK10 | 0.43675628 |
| 116 | ROCK2 | 0.43467616 |
| 117 | PRKG1 | 0.43384324 |
| 118 | DAPK2 | 0.43330592 |
| 119 | NEK6 | 0.42603118 |
| 120 | BMPR2 | 0.41976477 |
| 121 | FGR | 0.41311112 |
| 122 | PRKACG | 0.40829144 |
| 123 | CSNK1E | 0.39344666 |
| 124 | SGK3 | 0.39043715 |
| 125 | RPS6KA3 | 0.38099493 |
| 126 | YES1 | 0.37268508 |
| 127 | AKT3 | 0.36493063 |
| 128 | EIF2AK2 | 0.35389393 |
| 129 | PRKDC | 0.34944115 |
| 130 | WEE1 | 0.31999668 |
| 131 | STK24 | 0.31741995 |
| 132 | PRKCA | 0.28728649 |
| 133 | SRC | 0.25115900 |
| 134 | MKNK1 | 0.24913417 |
| 135 | MAPK15 | 0.23958730 |
| 136 | RPS6KB1 | 0.22878990 |
| 137 | MAPK9 | 0.22721836 |
| 138 | PIM2 | 0.20253793 |
| 139 | FYN | 0.19803265 |
| 140 | GSK3B | 0.19401228 |
| 141 | PRKCB | 0.18923201 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.96914731 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.45426175 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.74328831 |
| 4 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 2.67201499 |
| 5 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.57718301 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.54743711 |
| 7 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.44627876 |
| 8 | Cocaine addiction_Homo sapiens_hsa05030 | 2.44240915 |
| 9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.33654046 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.33197530 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.30255829 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.26929675 |
| 13 | Olfactory transduction_Homo sapiens_hsa04740 | 2.21838334 |
| 14 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.20858501 |
| 15 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.17817233 |
| 16 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.17640075 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 2.14237332 |
| 18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.10158307 |
| 19 | Long-term potentiation_Homo sapiens_hsa04720 | 2.09633475 |
| 20 | Parkinsons disease_Homo sapiens_hsa05012 | 2.00587487 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.99515145 |
| 22 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.89309713 |
| 23 | Salivary secretion_Homo sapiens_hsa04970 | 1.79638428 |
| 24 | Long-term depression_Homo sapiens_hsa04730 | 1.79507011 |
| 25 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.74484946 |
| 26 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.73585253 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.70695854 |
| 28 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.69254839 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.68472230 |
| 30 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.66345668 |
| 31 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.63786355 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.53084371 |
| 33 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.48415077 |
| 34 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.46949241 |
| 35 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.44692785 |
| 36 | Protein export_Homo sapiens_hsa03060 | 1.41507531 |
| 37 | Gap junction_Homo sapiens_hsa04540 | 1.40354735 |
| 38 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.38037903 |
| 39 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.31401660 |
| 40 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.29547236 |
| 41 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28662061 |
| 42 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.24778759 |
| 43 | Huntingtons disease_Homo sapiens_hsa05016 | 1.24001652 |
| 44 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.15016798 |
| 45 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.14712825 |
| 46 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.07960969 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.06645419 |
| 48 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.04622275 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.02130461 |
| 50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.01765419 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.01086307 |
| 52 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.00997277 |
| 53 | Melanogenesis_Homo sapiens_hsa04916 | 0.98020722 |
| 54 | Axon guidance_Homo sapiens_hsa04360 | 0.97154840 |
| 55 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.94665777 |
| 56 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.94551231 |
| 57 | Lysosome_Homo sapiens_hsa04142 | 0.90384627 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.89671791 |
| 59 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.88018432 |
| 60 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.87203201 |
| 61 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.82403503 |
| 62 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.82233497 |
| 63 | Alcoholism_Homo sapiens_hsa05034 | 0.80066968 |
| 64 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.77555715 |
| 65 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.77349161 |
| 66 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.76279047 |
| 67 | Glioma_Homo sapiens_hsa05214 | 0.75377201 |
| 68 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.74350843 |
| 69 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.73420838 |
| 70 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.72118953 |
| 71 | Phototransduction_Homo sapiens_hsa04744 | 0.70156290 |
| 72 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.69957011 |
| 73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.69106371 |
| 74 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.68934318 |
| 75 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.68565770 |
| 76 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.66487215 |
| 77 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.66028131 |
| 78 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.63711005 |
| 79 | Prion diseases_Homo sapiens_hsa05020 | 0.62259454 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.61932342 |
| 81 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.60766988 |
| 82 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58259017 |
| 83 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.57512380 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.53546429 |
| 85 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.52512143 |
| 86 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.51576587 |
| 87 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.51381668 |
| 88 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.51071321 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.50025831 |
| 90 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.49635388 |
| 91 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.48058647 |
| 92 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.45606598 |
| 93 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.43982982 |
| 94 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.43523652 |
| 95 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.42804892 |
| 96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.42686758 |
| 97 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.40107761 |
| 98 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.39620300 |
| 99 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.39152684 |
| 100 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.38099993 |
| 101 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.37563893 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36286618 |
| 103 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.36148480 |
| 104 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.34939807 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.34642347 |
| 106 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33730456 |
| 107 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.33255385 |
| 108 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.32735901 |
| 109 | Phagosome_Homo sapiens_hsa04145 | 0.32511996 |
| 110 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.32005231 |
| 111 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31952966 |
| 112 | Endocytosis_Homo sapiens_hsa04144 | 0.31701386 |
| 113 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.30129810 |
| 114 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.30044112 |
| 115 | Melanoma_Homo sapiens_hsa05218 | 0.29953866 |
| 116 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.29952837 |
| 117 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.29803382 |
| 118 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29743699 |
| 119 | Circadian rhythm_Homo sapiens_hsa04710 | 0.29405851 |
| 120 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.29328863 |
| 121 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.26225729 |
| 122 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25832145 |
| 123 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.23422409 |
| 124 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.21772086 |
| 125 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.21619765 |
| 126 | Bile secretion_Homo sapiens_hsa04976 | 0.18915401 |
| 127 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.18379002 |
| 128 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.17649197 |

