TMEM255B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.23532730
2piRNA metabolic process (GO:0034587)6.06960102
3gonadal mesoderm development (GO:0007506)5.42551353
4substrate-dependent cell migration (GO:0006929)4.81269903
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.81045861
6phenol-containing compound catabolic process (GO:0019336)4.77797610
7righting reflex (GO:0060013)4.68892972
8cardiac myofibril assembly (GO:0055003)4.64130424
9blood vessel maturation (GO:0001955)4.62450858
10lymphangiogenesis (GO:0001946)4.59853580
11maturation of 5.8S rRNA (GO:0000460)4.50609304
12behavioral response to ethanol (GO:0048149)4.33850212
13potassium ion export (GO:0071435)4.31667780
14virion attachment to host cell (GO:0019062)4.26845858
15adhesion of symbiont to host cell (GO:0044650)4.26845858
16negative regulation of nitric oxide biosynthetic process (GO:0045019)4.24213848
17regulation of phospholipid biosynthetic process (GO:0071071)4.11904231
18regulation of meiosis (GO:0040020)4.08168635
19negative regulation of smooth muscle cell differentiation (GO:0051151)4.07986626
20ovulation cycle (GO:0042698)3.96997853
21endothelium development (GO:0003158)3.92250291
22myofibril assembly (GO:0030239)3.87009292
23hyaluronan catabolic process (GO:0030214)3.84850058
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.84021187
25neuron cell-cell adhesion (GO:0007158)3.79359864
26female gamete generation (GO:0007292)3.76727671
27notochord development (GO:0030903)3.75588311
28regulation of membrane repolarization (GO:0060306)3.72983835
29negative regulation of protein localization to cell surface (GO:2000009)3.72296298
30vascular endothelial growth factor signaling pathway (GO:0038084)3.67023332
31adhesion of symbiont to host (GO:0044406)3.56491100
32regulation of transforming growth factor beta2 production (GO:0032909)3.50947330
33vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.50818523
34negative regulation of nitric-oxide synthase activity (GO:0051001)3.46436762
35angiogenesis involved in wound healing (GO:0060055)3.43401060
36regulation of acrosome reaction (GO:0060046)3.42790614
37detection of mechanical stimulus (GO:0050982)3.42128663
38wound healing, spreading of epidermal cells (GO:0035313)3.41681232
39regulation of meiotic cell cycle (GO:0051445)3.35175843
40cell adhesion mediated by integrin (GO:0033627)3.29630258
41cardiac muscle cell development (GO:0055013)3.28347184
42DNA methylation involved in gamete generation (GO:0043046)3.26395562
43glomerular filtration (GO:0003094)3.25990002
44response to magnesium ion (GO:0032026)3.25186979
45sarcomere organization (GO:0045214)3.24460577
46sprouting angiogenesis (GO:0002040)3.23481354
47cardiac cell development (GO:0055006)3.21294464
48positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20082155
49regulation of exit from mitosis (GO:0007096)3.18634146
50norepinephrine metabolic process (GO:0042415)3.17953105
51histone H2A monoubiquitination (GO:0035518)3.16973783
52negative regulation of meiosis (GO:0045835)3.16107717
53positive regulation of heat generation (GO:0031652)3.15622707
54regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.15477356
55cGMP-mediated signaling (GO:0019934)3.15007243
56ventricular cardiac muscle cell action potential (GO:0086005)3.14343880
57positive regulation of vasculogenesis (GO:2001214)3.13598406
58heart trabecula formation (GO:0060347)3.12644767
59endothelial tube morphogenesis (GO:0061154)3.12339170
60morphogenesis of an endothelium (GO:0003159)3.12339170
61barbed-end actin filament capping (GO:0051016)3.12262626
62keratan sulfate biosynthetic process (GO:0018146)3.11327481
63regulation of vitamin D biosynthetic process (GO:0060556)3.11128811
64regulation of actin filament-based movement (GO:1903115)3.11126810
65microtubule severing (GO:0051013)3.09854729
66regulation of membrane protein ectodomain proteolysis (GO:0051043)3.09039724
67positive regulation of smooth muscle cell migration (GO:0014911)3.08284975
68oocyte maturation (GO:0001556)3.08270560
69cartilage morphogenesis (GO:0060536)3.07980407
70striatum development (GO:0021756)3.07798175
71positive regulation of chemokine biosynthetic process (GO:0045080)3.06444992
72base-excision repair, AP site formation (GO:0006285)3.06013080
73regulation of mononuclear cell migration (GO:0071675)3.05905287
74citrulline biosynthetic process (GO:0019240)3.04572278
75negative regulation of reproductive process (GO:2000242)3.04534457
76neurotransmitter catabolic process (GO:0042135)3.02660657
77glycoprotein catabolic process (GO:0006516)3.01993593
78negative regulation of blood vessel endothelial cell migration (GO:0043537)2.99728822
79endothelial cell chemotaxis (GO:0035767)2.98853560
80regulation of timing of cell differentiation (GO:0048505)2.98136428
81endosome to pigment granule transport (GO:0043485)2.97366390
82endosome to melanosome transport (GO:0035646)2.97366390
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96068352
84negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.95990279
85male meiosis (GO:0007140)2.95920067
86positive regulation of natural killer cell differentiation (GO:0032825)2.95558385
87glycerophospholipid catabolic process (GO:0046475)2.94569540
88meiotic cell cycle (GO:0051321)2.91563728
89negative regulation of hormone metabolic process (GO:0032351)2.91042251
90negative regulation of hormone biosynthetic process (GO:0032353)2.91042251
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89104245
92regulation of cardioblast differentiation (GO:0051890)2.88976676
93ventricular cardiac muscle cell development (GO:0055015)2.88935264
94protein localization to endosome (GO:0036010)2.88790560
95multicellular organism reproduction (GO:0032504)2.87957899
96venous blood vessel morphogenesis (GO:0048845)2.86925400
97regulation of smooth muscle cell differentiation (GO:0051150)2.86899351
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.85654263
99negative regulation of platelet activation (GO:0010544)2.84273786
100DNA damage induced protein phosphorylation (GO:0006975)2.83682232
101histone H2A ubiquitination (GO:0033522)2.83529925
102regulation of cardiac muscle cell contraction (GO:0086004)2.83380575
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.83272402
104positive regulation of sodium ion transmembrane transport (GO:1902307)2.83033065
105type B pancreatic cell development (GO:0003323)2.81256243
106protein kinase C signaling (GO:0070528)2.79477640
107renal filtration (GO:0097205)2.79420186
108axon extension involved in axon guidance (GO:0048846)2.78936121
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.78936121
110monocyte chemotaxis (GO:0002548)2.78289052
111dermatan sulfate biosynthetic process (GO:0030208)2.78254737
112behavioral response to nicotine (GO:0035095)2.77321475
113regulation of relaxation of muscle (GO:1901077)2.75434629
114negative regulation of monooxygenase activity (GO:0032769)2.71694294
115oxygen transport (GO:0015671)2.71406361
116endothelial cell morphogenesis (GO:0001886)2.71017151
117negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69909404
118attachment of spindle microtubules to kinetochore (GO:0008608)2.69114511
119mannose metabolic process (GO:0006013)2.68621279
120facial nerve structural organization (GO:0021612)2.67842033
121regulation of integrin-mediated signaling pathway (GO:2001044)2.67654919
122apoptotic cell clearance (GO:0043277)2.66022492
123regulation of heat generation (GO:0031650)2.65629108
124glycosphingolipid catabolic process (GO:0046479)2.64941483
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64576081
126regulation of nitric oxide biosynthetic process (GO:0045428)2.63984431
127endothelial cell proliferation (GO:0001935)2.63953619
128chondroitin sulfate catabolic process (GO:0030207)2.62407013
129positive regulation of receptor recycling (GO:0001921)2.62130264
130regulation of blood vessel endothelial cell migration (GO:0043535)2.61518661
131extracellular fibril organization (GO:0043206)2.60465250
132regulation of development, heterochronic (GO:0040034)2.60305513
133negative regulation of meiotic cell cycle (GO:0051447)2.60220140
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59872000
135outflow tract septum morphogenesis (GO:0003148)2.59216901
136negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59176973
137negative regulation of focal adhesion assembly (GO:0051895)2.59122716
138negative regulation of cell junction assembly (GO:1901889)2.59122716
139negative regulation of adherens junction organization (GO:1903392)2.59122716
140positive regulation of protein kinase C signaling (GO:0090037)2.58371084
141sphingosine metabolic process (GO:0006670)2.58215704
142cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.58155506
143semaphorin-plexin signaling pathway (GO:0071526)2.58062769
144positive regulation of natural killer cell activation (GO:0032816)2.56966620
145negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.56369970
146regulation of Golgi to plasma membrane protein transport (GO:0042996)2.55070148
147stress fiber assembly (GO:0043149)2.54540703
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54303216
149dermatan sulfate metabolic process (GO:0030205)2.54233401
150regulation of endothelial cell differentiation (GO:0045601)2.54083482
151fibril organization (GO:0097435)2.54046723
152regulation of chemokine biosynthetic process (GO:0045073)2.53751619
153negative regulation of interleukin-12 production (GO:0032695)2.53407453
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52520273
155transcytosis (GO:0045056)2.52128132
156relaxation of smooth muscle (GO:0044557)2.52006874
157chaperone-mediated protein transport (GO:0072321)2.51114343
158positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50985308
159cellular response to arsenic-containing substance (GO:0071243)2.50626492
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50049344
161locomotory exploration behavior (GO:0035641)2.49362211
162positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.47133222
163lymph vessel development (GO:0001945)2.46392258
164amino sugar catabolic process (GO:0046348)2.46322190
165regulation of T-helper 1 cell differentiation (GO:0045625)2.45739582
166regulation of glomerular filtration (GO:0003093)2.44914055
167endodermal cell differentiation (GO:0035987)2.43931880
168nephron tubule development (GO:0072080)2.43391741
169fibroblast migration (GO:0010761)2.42789088
170pinocytosis (GO:0006907)2.41803695
171plasma membrane repair (GO:0001778)2.41658878
172regulation of smooth muscle cell migration (GO:0014910)2.41147668
173peptide catabolic process (GO:0043171)2.40686193
174regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.40459683
175regulation of cytokine secretion involved in immune response (GO:0002739)2.40395438
176regulation of glucocorticoid metabolic process (GO:0031943)2.40338440
177ganglion development (GO:0061548)2.39138354
178germinal center formation (GO:0002467)2.37996093
179type B pancreatic cell proliferation (GO:0044342)2.37907218
180cellular response to exogenous dsRNA (GO:0071360)2.37068367
181lysosome organization (GO:0007040)2.36969852
182lytic vacuole organization (GO:0080171)2.36969852
183negative regulation of lipid storage (GO:0010888)2.36921718
184negative regulation of protein tyrosine kinase activity (GO:0061099)2.35852409
185negative regulation of endothelial cell migration (GO:0010596)2.35046023
186negative regulation of systemic arterial blood pressure (GO:0003085)2.33819993
187negative regulation of smooth muscle cell migration (GO:0014912)2.33335750
188low-density lipoprotein particle clearance (GO:0034383)2.33251027
189glycolipid catabolic process (GO:0019377)2.32476290
190positive regulation of calcium ion import (GO:0090280)2.31881623
191response to peptidoglycan (GO:0032494)2.30342306
192regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29610185
193ceramide catabolic process (GO:0046514)2.28847543
194positive regulation of axon extension (GO:0045773)2.27866066
195regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27352482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.11321214
2AR_21572438_ChIP-Seq_LNCaP_Human3.44149052
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.21744642
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.07379342
5TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.78787290
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.76880449
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.62460519
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.59430590
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56738479
10EZH2_22144423_ChIP-Seq_EOC_Human2.48922959
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.48761643
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32597245
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.26914320
14JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23377922
15JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20620956
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20258375
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20009796
18IGF1R_20145208_ChIP-Seq_DFB_Human2.18546054
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11323866
20GBX2_23144817_ChIP-Seq_PC3_Human2.10228943
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.06501686
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05109505
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03781947
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03332385
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95643008
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.90398794
27SPI1_23127762_ChIP-Seq_K562_Human1.86062344
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85537600
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85537600
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83553421
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79358082
32BRD4_25478319_ChIP-Seq_HGPS_Human1.77712435
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76524451
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73069630
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69780991
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69183354
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.68720628
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63026012
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62126160
40DROSHA_22980978_ChIP-Seq_HELA_Human1.60517060
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59943387
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59756839
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58915751
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58880420
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.58100796
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57938212
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57362880
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57106233
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56698223
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56618819
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56430732
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55050817
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54045650
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53968443
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53547335
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53473944
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52023894
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50672619
59CJUN_26792858_Chip-Seq_BT549_Human1.49896873
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49677336
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48055538
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46224096
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45861048
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43929416
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43828103
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40808695
67SMAD4_21799915_ChIP-Seq_A2780_Human1.40784152
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.40349372
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40241012
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39166937
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38883174
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38094779
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.37476058
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.37405586
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.36622030
76STAT3_23295773_ChIP-Seq_U87_Human1.36570265
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.36317566
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.35373852
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34109356
80LXR_22292898_ChIP-Seq_THP-1_Human1.31262432
81TP53_16413492_ChIP-PET_HCT116_Human1.31158771
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31112211
83VDR_24763502_ChIP-Seq_THP-1_Human1.30511669
84BCAT_22108803_ChIP-Seq_LS180_Human1.30444870
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29772365
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29004388
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28914110
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.28669097
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.28669097
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28129967
91STAT1_20625510_ChIP-Seq_HELA_Human1.26696571
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.26044887
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25431353
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.25033819
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.24533290
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.24255182
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21822739
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21679044
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.20530018
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20328439
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19888020
102NFYA_21822215_ChIP-Seq_K562_Human1.19262071
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18988153
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18902139
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.18277453
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17548976
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17548976
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16789236
109AR_25329375_ChIP-Seq_VCAP_Human1.16688499
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15550499
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15078802
112TP53_22127205_ChIP-Seq_IMR90_Human1.13821418
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13719815
114AR_21909140_ChIP-Seq_LNCAP_Human1.13118493
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12709274
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12370685
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11776996
118TP53_23651856_ChIP-Seq_MEFs_Mouse1.11475611
119TAF15_26573619_Chip-Seq_HEK293_Human1.10711098
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09536565
121FUS_26573619_Chip-Seq_HEK293_Human1.09445385
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09038319
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08965538
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08965538
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08866265
126P300_19829295_ChIP-Seq_ESCs_Human1.06617544
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05830381
128NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05101069
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04295331
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03432315
131STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02465204
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02304179
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02140539
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01281313
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01231770
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01231770
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.00305751
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00003265
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99872922
140TBL1_22424771_ChIP-Seq_293T_Human0.98839115
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.98674233
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98513221
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.98268035
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97998182
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97418367
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96972186
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.95770679
148TFEB_21752829_ChIP-Seq_HELA_Human0.94780977
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94763081
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94636541
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.94601152
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94049861
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93349856
154SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93053021
155PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92955478
156VDR_24787735_ChIP-Seq_THP-1_Human0.92897066
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92592718
158TCF4_23295773_ChIP-Seq_U87_Human0.91994568
159GATA1_19941826_ChIP-Seq_K562_Human0.91830808
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91804021
161MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91802855
162GATA2_21666600_ChIP-Seq_HMVEC_Human0.91631536
163LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91417319
164RNF2_27304074_Chip-Seq_NSC_Mouse0.91240818
165BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91195046
166P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91157509
167UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89354439
168BCL6_27268052_Chip-Seq_Bcells_Human0.89053733
169UBF1/2_26484160_Chip-Seq_HMECs_Human0.88767943
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87203409
171SCL_19346495_ChIP-Seq_HPC-7_Human0.82566951
172MITF_21258399_ChIP-Seq_MELANOMA_Human0.81402031
173GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80524282
174TP63_17297297_ChIP-ChIP_HaCaT_Human0.79949299
175EGR1_19374776_ChIP-ChIP_THP-1_Human0.79525148
176VDR_22108803_ChIP-Seq_LS180_Human0.78756959
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77872199
178E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77567785
179TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77219967
180PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76885957
181SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76851322
182RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76693795
183BCOR_27268052_Chip-Seq_Bcells_Human0.76659695
184EGR1_19032775_ChIP-ChIP_M12_Human0.76547960
185VDR_21846776_ChIP-Seq_THP-1_Human0.75469756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.41633347
2MP0002837_dystrophic_cardiac_calcinosis3.83636528
3MP0003303_peritoneal_inflammation3.60672711
4MP0006054_spinal_hemorrhage3.57521276
5MP0005058_abnormal_lysosome_morphology3.37729803
6MP0004215_abnormal_myocardial_fiber3.19850848
7MP0003718_maternal_effect3.14998715
8MP0001879_abnormal_lymphatic_vessel3.11742576
9MP0009840_abnormal_foam_cell3.09129653
10MP0010368_abnormal_lymphatic_system3.05580498
11MP0004084_abnormal_cardiac_muscle3.02331278
12MP0000751_myopathy2.95903590
13MP0004510_myositis2.91635296
14MP0004036_abnormal_muscle_relaxation2.56906192
15MP0005646_abnormal_pituitary_gland2.55730195
16MP0003950_abnormal_plasma_membrane2.43895969
17MP0002822_catalepsy2.42489168
18MP0003172_abnormal_lysosome_physiology2.35373739
19MP0006082_CNS_inflammation2.30450210
20MP0005451_abnormal_body_composition2.23015438
21MP0006138_congestive_heart_failure2.21806216
22MP0009764_decreased_sensitivity_to2.17192566
23MP0003011_delayed_dark_adaptation2.14098629
24MP0008438_abnormal_cutaneous_collagen2.10369804
25MP0005595_abnormal_vascular_smooth2.09690679
26MP0004145_abnormal_muscle_electrophysio2.07274787
27MP0002138_abnormal_hepatobiliary_system2.06151772
28MP0003879_abnormal_hair_cell2.04640137
29MP0002148_abnormal_hypersensitivity_rea1.93992110
30MP0010386_abnormal_urinary_bladder1.91161348
31MP0003191_abnormal_cellular_cholesterol1.80926685
32MP0003941_abnormal_skin_development1.80525622
33MP0005330_cardiomyopathy1.75860164
34MP0009785_altered_susceptibility_to1.73951020
35MP0003436_decreased_susceptibility_to1.73741558
36MP0004272_abnormal_basement_membrane1.72091348
37MP0004270_analgesia1.70432085
38MP0002972_abnormal_cardiac_muscle1.70342382
39MP0005187_abnormal_penis_morphology1.69798817
40MP0001529_abnormal_vocalization1.68792502
41MP0001542_abnormal_bone_strength1.68459701
42MP0003137_abnormal_impulse_conducting1.68416476
43MP0002127_abnormal_cardiovascular_syste1.68113423
44MP0008004_abnormal_stomach_pH1.67613734
45MP0008775_abnormal_heart_ventricle1.63632839
46MP0005620_abnormal_muscle_contractility1.63115632
47MP0005670_abnormal_white_adipose1.59243431
48MP0002254_reproductive_system_inflammat1.58542238
49MP0004087_abnormal_muscle_fiber1.56494477
50MP0004085_abnormal_heartbeat1.56364969
51MP0001485_abnormal_pinna_reflex1.56000952
52MP0003300_gastrointestinal_ulcer1.55148842
53MP0003705_abnormal_hypodermis_morpholog1.53613975
54MP0000750_abnormal_muscle_regeneration1.52026069
55MP0004484_altered_response_of1.51403185
56MP0001533_abnormal_skeleton_physiology1.50813523
57MP0002295_abnormal_pulmonary_circulatio1.50578512
58MP0002933_joint_inflammation1.48950494
59MP0008877_abnormal_DNA_methylation1.48326575
60MP0000749_muscle_degeneration1.46377506
61MP0002419_abnormal_innate_immunity1.46137575
62MP0002106_abnormal_muscle_physiology1.45198365
63MP0005395_other_phenotype1.44074167
64MP0003699_abnormal_female_reproductive1.42648157
65MP0001905_abnormal_dopamine_level1.41828839
66MP0002332_abnormal_exercise_endurance1.40791660
67MP0005408_hypopigmentation1.40589810
68MP0000767_abnormal_smooth_muscle1.39234934
69MP0001851_eye_inflammation1.36857765
70MP0002249_abnormal_larynx_morphology1.36650406
71MP0005385_cardiovascular_system_phenoty1.36204508
72MP0001544_abnormal_cardiovascular_syste1.36204508
73MP0003566_abnormal_cell_adhesion1.32245527
74MP0003279_aneurysm1.30150061
75MP0002998_abnormal_bone_remodeling1.29007223
76MP0003075_altered_response_to1.26811160
77MP0009278_abnormal_bone_marrow1.23605357
78MP0002638_abnormal_pupillary_reflex1.21750305
79MP0004858_abnormal_nervous_system1.21687035
80MP0000249_abnormal_blood_vessel1.20480889
81MP0005167_abnormal_blood-brain_barrier1.19827597
82MP0005369_muscle_phenotype1.19533963
83MP0003724_increased_susceptibility_to1.14858088
84MP0001545_abnormal_hematopoietic_system1.14536038
85MP0005397_hematopoietic_system_phenotyp1.14536038
86MP0001853_heart_inflammation1.14136552
87MP0005025_abnormal_response_to1.13814266
88MP0000759_abnormal_skeletal_muscle1.12665612
89MP0002877_abnormal_melanocyte_morpholog1.11970233
90MP0002653_abnormal_ependyma_morphology1.11535252
91MP0000604_amyloidosis1.11241723
92MP0003448_altered_tumor_morphology1.10537514
93MP0002102_abnormal_ear_morphology1.10277134
94MP0005164_abnormal_response_to1.09863875
95MP0001119_abnormal_female_reproductive1.09509782
96MP0005000_abnormal_immune_tolerance1.06439635
97MP0005023_abnormal_wound_healing1.05406240
98MP0003828_pulmonary_edema1.05208067
99MP0001790_abnormal_immune_system1.05122776
100MP0005387_immune_system_phenotype1.05122776
101MP0010630_abnormal_cardiac_muscle1.04242802
102MP0000026_abnormal_inner_ear1.03018370
103MP0000534_abnormal_ureter_morphology1.02397387
104MP0000579_abnormal_nail_morphology1.02274897
105MP0000465_gastrointestinal_hemorrhage1.01422429
106MP0004185_abnormal_adipocyte_glucose1.00359790
107MP0005464_abnormal_platelet_physiology1.00261405
108MP0005248_abnormal_Harderian_gland0.99704141
109MP0001835_abnormal_antigen_presentation0.99122882
110MP0000343_altered_response_to0.96366421
111MP0002734_abnormal_mechanical_nocicepti0.94350467
112MP0002452_abnormal_antigen_presenting0.93677246
113MP0002405_respiratory_system_inflammati0.93627118
114MP0008469_abnormal_protein_level0.92089063
115MP0001614_abnormal_blood_vessel0.91855664
116MP0000733_abnormal_muscle_development0.91394984
117MP0005310_abnormal_salivary_gland0.90877646
118MP0001849_ear_inflammation0.90369177
119MP0000685_abnormal_immune_system0.89788718
120MP0009384_cardiac_valve_regurgitation0.89419133
121MP0005390_skeleton_phenotype0.89080609
122MP0002128_abnormal_blood_circulation0.88836466
123MP0002269_muscular_atrophy0.87498423
124MP0002723_abnormal_immune_serum0.86940825
125MP0009250_abnormal_appendicular_skeleto0.85742285
126MP0000015_abnormal_ear_pigmentation0.85710706
127MP0004947_skin_inflammation0.85581695
128MP0000013_abnormal_adipose_tissue0.85441603
129MP0003183_abnormal_peptide_metabolism0.85100718
130MP0005257_abnormal_intraocular_pressure0.85016440
131MP0005165_increased_susceptibility_to0.84844691
132MP0000462_abnormal_digestive_system0.84183757
133MP0001958_emphysema0.83914466
134MP0005666_abnormal_adipose_tissue0.83795695
135MP0001845_abnormal_inflammatory_respons0.83210114
136MP0005171_absent_coat_pigmentation0.82943975
137MP0001440_abnormal_grooming_behavior0.82802497
138MP0002168_other_aberrant_phenotype0.81842134
139MP0000858_altered_metastatic_potential0.81560134
140MP0003186_abnormal_redox_activity0.80579831
141MP0006276_abnormal_autonomic_nervous0.79311561
142MP0000538_abnormal_urinary_bladder0.77802137
143MP0000639_abnormal_adrenal_gland0.77598850
144MP0001929_abnormal_gametogenesis0.77179659
145MP0003937_abnormal_limbs/digits/tail_de0.77006215
146MP0003091_abnormal_cell_migration0.76764611
147MP0003045_fibrosis0.76322167
148MP0010030_abnormal_orbit_morphology0.76164991
149MP0001486_abnormal_startle_reflex0.76069582
150MP0005386_behavior/neurological_phenoty0.76015450
151MP0004924_abnormal_behavior0.76015450
152MP0004130_abnormal_muscle_cell0.73209914
153MP0000569_abnormal_digit_pigmentation0.72940658
154MP0005166_decreased_susceptibility_to0.72483543
155MP0001502_abnormal_circadian_rhythm0.72395753
156MP0000371_diluted_coat_color0.71660670
157MP0000653_abnormal_sex_gland0.71547341
158MP0001963_abnormal_hearing_physiology0.71501597
159MP0003195_calcinosis0.71125161
160MP0005377_hearing/vestibular/ear_phenot0.70877212
161MP0003878_abnormal_ear_physiology0.70877212
162MP0006072_abnormal_retinal_apoptosis0.70102542
163MP0003632_abnormal_nervous_system0.68579069
164MP0001915_intracranial_hemorrhage0.68408091
165MP0002282_abnormal_trachea_morphology0.68233202
166MP0003880_abnormal_central_pattern0.67679391
167MP0010155_abnormal_intestine_physiology0.67593101
168MP0003806_abnormal_nucleotide_metabolis0.66827578
169MP0002184_abnormal_innervation0.66554918
170MP0000266_abnormal_heart_morphology0.66178546
171MP0001663_abnormal_digestive_system0.64077666
172MP0002896_abnormal_bone_mineralization0.63106608
173MP0000230_abnormal_systemic_arterial0.63003177
174MP0008874_decreased_physiological_sensi0.62922764
175MP0001501_abnormal_sleep_pattern0.62154029
176MP0001819_abnormal_immune_cell0.61828185
177MP0005197_abnormal_uvea_morphology0.61523924

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.42084680
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.42084680
3Abnormality of glycolipid metabolism (HP:0010969)6.42084680
4Male infertility (HP:0003251)5.94574134
5Dysostosis multiplex (HP:0000943)4.64927712
6Muscle fiber splitting (HP:0003555)4.56592163
7Increased cerebral lipofuscin (HP:0011813)4.55413816
8Atrial fibrillation (HP:0005110)4.42459170
9Exercise-induced myalgia (HP:0003738)4.34190528
10Sudden death (HP:0001699)4.23670147
11Hematochezia (HP:0002573)4.20852946
12Vacuolated lymphocytes (HP:0001922)4.19633847
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.17144862
14Primary atrial arrhythmia (HP:0001692)4.13190822
15Abnormality of mucopolysaccharide metabolism (HP:0011020)4.10604964
16Abnormality of polysaccharide metabolism (HP:0011012)4.10604964
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.10604964
18Supraventricular arrhythmia (HP:0005115)3.95104043
19Syncope (HP:0001279)3.93676297
20Nuclear cataract (HP:0100018)3.92581839
21Ventricular fibrillation (HP:0001663)3.92508331
22Supraventricular tachycardia (HP:0004755)3.91284082
23Urinary glycosaminoglycan excretion (HP:0003541)3.77676765
24Mucopolysacchariduria (HP:0008155)3.77676765
25Loss of speech (HP:0002371)3.68398130
26Prolonged QT interval (HP:0001657)3.68181877
27Hypothermia (HP:0002045)3.60641307
28Ventricular tachycardia (HP:0004756)3.55857717
29Cervical subluxation (HP:0003308)3.47312629
30Systemic lupus erythematosus (HP:0002725)3.40084949
31Abnormality of the vasculature of the conjunctiva (HP:0008054)3.39945317
32Myotonia (HP:0002486)3.35504359
33Premature rupture of membranes (HP:0001788)3.28885405
34Cortical dysplasia (HP:0002539)3.28211252
35Axonal loss (HP:0003447)3.26515590
36Protrusio acetabuli (HP:0003179)3.25888040
37Arterial tortuosity (HP:0005116)3.25564480
38Spontaneous hematomas (HP:0007420)3.24039810
39Joint stiffness (HP:0001387)3.18157450
40Lipoatrophy (HP:0100578)3.15767052
41Fetal akinesia sequence (HP:0001989)3.12842761
42Conjunctival telangiectasia (HP:0000524)3.12750666
43Calf muscle hypertrophy (HP:0008981)3.09755692
44Abnormality of the calf musculature (HP:0001430)3.07048004
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.00918961
46Congenital sensorineural hearing impairment (HP:0008527)3.00059918
47Vascular tortuosity (HP:0004948)2.95316747
48Scotoma (HP:0000575)2.94159056
49Autoimmune thrombocytopenia (HP:0001973)2.93245496
50Abnormal auditory evoked potentials (HP:0006958)2.91657471
51Insulin-resistant diabetes mellitus (HP:0000831)2.89999760
52Infertility (HP:0000789)2.88019268
53Neurofibrillary tangles (HP:0002185)2.86951803
54Hyporeflexia of lower limbs (HP:0002600)2.83995621
55Nonimmune hydrops fetalis (HP:0001790)2.83722294
56Myocardial infarction (HP:0001658)2.83395495
57Disinhibition (HP:0000734)2.82524213
58Myokymia (HP:0002411)2.82467443
59Muscle hypertrophy of the lower extremities (HP:0008968)2.77430758
60Cerebral aneurysm (HP:0004944)2.75505655
61Apathy (HP:0000741)2.74609710
62Premature ovarian failure (HP:0008209)2.73056622
63Spinal rigidity (HP:0003306)2.71639442
64Sparse lateral eyebrow (HP:0005338)2.65453149
65Papillary thyroid carcinoma (HP:0002895)2.64633788
66J-shaped sella turcica (HP:0002680)2.62797265
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54224545
68Diminished motivation (HP:0000745)2.53496997
69Myoglobinuria (HP:0002913)2.51378566
70Bundle branch block (HP:0011710)2.51082605
71Vertebral compression fractures (HP:0002953)2.50065893
72Spondylolisthesis (HP:0003302)2.48732628
73Anosmia (HP:0000458)2.47876440
74Ventricular arrhythmia (HP:0004308)2.44651462
75Esophageal varix (HP:0002040)2.39755653
76Dilated cardiomyopathy (HP:0001644)2.38342061
77Distal upper limb amyotrophy (HP:0007149)2.37597805
78Upper limb amyotrophy (HP:0009129)2.37597805
79Nonprogressive disorder (HP:0003680)2.36113200
80Shawl scrotum (HP:0000049)2.35296645
81Mutism (HP:0002300)2.34517211
82Prolonged neonatal jaundice (HP:0006579)2.32077998
83Difficulty climbing stairs (HP:0003551)2.31469337
84Aplasia involving bones of the upper limbs (HP:0009823)2.31080495
85Aplasia of the phalanges of the hand (HP:0009802)2.31080495
86Aplasia involving bones of the extremities (HP:0009825)2.31080495
87Follicular hyperkeratosis (HP:0007502)2.28821867
88Aortic aneurysm (HP:0004942)2.28810205
89Abnormality of the nasal mucosa (HP:0000433)2.27091747
90Aortic dissection (HP:0002647)2.26365644
91Flat capital femoral epiphysis (HP:0003370)2.26284352
92Pulmonary artery stenosis (HP:0004415)2.25980139
93Abnormality of the labia minora (HP:0012880)2.25912756
94Portal hypertension (HP:0001409)2.25131554
95Aortic valve stenosis (HP:0001650)2.24811659
96Increased connective tissue (HP:0009025)2.24059042
97Hypoplastic ischia (HP:0003175)2.22977974
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20746603
99Orthostatic hypotension (HP:0001278)2.20274319
100Difficulty running (HP:0009046)2.18324827
101EMG: myopathic abnormalities (HP:0003458)2.18200776
102Polycythemia (HP:0001901)2.16553300
103Neonatal hypoglycemia (HP:0001998)2.16042694
104Abnormal EKG (HP:0003115)2.15568206
105Glomerulonephritis (HP:0000099)2.14987421
106Abnormality of the left ventricular outflow tract (HP:0011103)2.13709098
107Subaortic stenosis (HP:0001682)2.13709098
108Reduced subcutaneous adipose tissue (HP:0003758)2.12660691
109Cerebral hemorrhage (HP:0001342)2.12503216
110Adrenal hypoplasia (HP:0000835)2.10675274
111Left ventricular hypertrophy (HP:0001712)2.09727865
112Abnormality of the hepatic vasculature (HP:0006707)2.09698215
113Ovoid vertebral bodies (HP:0003300)2.07772900
114Interstitial pulmonary disease (HP:0006530)2.06597149
115Hip contracture (HP:0003273)2.06589842
116Increased variability in muscle fiber diameter (HP:0003557)2.06570424
117Midline defect of the nose (HP:0004122)2.06501570
118Exercise-induced muscle cramps (HP:0003710)2.06494729
119Bilateral sensorineural hearing impairment (HP:0008619)2.06195934
120Right ventricular cardiomyopathy (HP:0011663)2.05653494
121Gowers sign (HP:0003391)2.04985781
122Albinism (HP:0001022)2.04768591
123Tetraparesis (HP:0002273)2.04040068
124Absent hand (HP:0004050)2.03247406
125Ankle contracture (HP:0006466)2.03082733
126Amyloidosis (HP:0011034)2.02057178
127Secondary amenorrhea (HP:0000869)2.01807679
128Asymmetric septal hypertrophy (HP:0001670)2.01313849
129Abnormality of the fovea (HP:0000493)2.00201125
130EMG: neuropathic changes (HP:0003445)1.99996494
131Abnormality of the pubic bones (HP:0003172)1.99720058
132Pulmonary hypertension (HP:0002092)1.99319080
133Progressive neurologic deterioration (HP:0002344)1.99060972
134Wrist flexion contracture (HP:0001239)1.98896974
135Abnormality of the ischium (HP:0003174)1.98440043
136Vertebral arch anomaly (HP:0008438)1.98103615
137Mucosal telangiectasiae (HP:0100579)1.97745786
138Muscle stiffness (HP:0003552)1.97736884
139Distal lower limb amyotrophy (HP:0008944)1.96323889
140Cerebral inclusion bodies (HP:0100314)1.93738230
141Heart block (HP:0012722)1.93490185
142Inappropriate behavior (HP:0000719)1.92772053
143Mesangial abnormality (HP:0001966)1.92095752
144Facial hemangioma (HP:0000329)1.92003985
145Hand muscle atrophy (HP:0009130)1.91703464
146Abnormality of lateral ventricle (HP:0030047)1.89385481
147Depressed nasal tip (HP:0000437)1.89142584
148Complement deficiency (HP:0004431)1.88956258
149Aortic regurgitation (HP:0001659)1.87948090
150Coxa valga (HP:0002673)1.87773694
151Acrocyanosis (HP:0001063)1.86213981
152Abnormal atrioventricular conduction (HP:0005150)1.83967693
153Long toe (HP:0010511)1.83585137
154Upper motor neuron abnormality (HP:0002127)1.83088049
155Abnormality of complement system (HP:0005339)1.82938237
156Primary amenorrhea (HP:0000786)1.82830635
157Atrioventricular block (HP:0001678)1.82337213
158Lymphangioma (HP:0100764)1.81467663
159Breast aplasia (HP:0100783)1.81045177
160Abnormality of macrophages (HP:0004311)1.81031678
161Nephritis (HP:0000123)1.80155384
162Esophageal neoplasm (HP:0100751)1.77609553
163Neoplasm of head and neck (HP:0012288)1.77609553
164Short nail (HP:0001799)1.77081048
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.76691754
166Adactyly (HP:0009776)1.76394123
167Abnormality of chromosome segregation (HP:0002916)1.76260904
168Broad ribs (HP:0000885)1.76202439
169Hyperglycemia (HP:0003074)1.76185588
170Short hallux (HP:0010109)1.75691536
171Hypergonadotropic hypogonadism (HP:0000815)1.73701349
172Palpitations (HP:0001962)1.73499130
173Lip pit (HP:0100267)1.72356414
174Shallow orbits (HP:0000586)1.72342462
175Flared iliac wings (HP:0002869)1.71015893
176Supranuclear gaze palsy (HP:0000605)1.70939751
177Distal lower limb muscle weakness (HP:0009053)1.70828834
178Thick nail (HP:0001805)1.69358625
179Aneurysm (HP:0002617)1.67136549
180Natal tooth (HP:0000695)1.66962852
181Chorioretinal atrophy (HP:0000533)1.66878380
182Thin bony cortex (HP:0002753)1.65733540
183Hypoplasia of the iris (HP:0007676)1.65712842
184Broad metatarsal (HP:0001783)1.65135603
185Retinal atrophy (HP:0001105)1.64685818
186Stroke (HP:0001297)1.63483173
187Wormian bones (HP:0002645)1.63301928
188Neoplasm of the peripheral nervous system (HP:0100007)1.62828731
189Atelectasis (HP:0100750)1.62644290
190Fibular aplasia (HP:0002990)1.62626281
191Blue sclerae (HP:0000592)1.61917261
192Genetic anticipation (HP:0003743)1.59763182
193Zonular cataract (HP:0010920)1.59224532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.85985005
2ERBB43.53805549
3MAP3K63.29619823
4LATS13.23469404
5LATS23.20515952
6IRAK33.09209638
7TAOK13.03421996
8TIE12.84319756
9INSRR2.69994218
10TESK12.55278345
11GRK72.53017849
12PHKG12.50345561
13PHKG22.50345561
14STK38L2.46136405
15DMPK2.44482999
16NME22.29352490
17LIMK12.09673403
18KSR22.04784166
19PDGFRA2.01317437
20TESK22.01070095
21STK242.00720300
22EEF2K1.91144011
23MAP2K31.90531450
24EPHA31.88065893
25EPHB21.86484727
26PIM21.82099001
27PRKD31.80785068
28CDK81.78914610
29CASK1.76551235
30MAP3K31.71091505
31TBK11.71038073
32MAPKAPK31.63236080
33FRK1.57689101
34TTN1.57442081
35PLK41.48658618
36RIPK11.43268228
37BRAF1.42705639
38PRKAA21.41398284
39ADRBK21.40867650
40MAPKAPK51.40011214
41MOS1.39327071
42NTRK11.37370762
43MYLK1.36665999
44ERN11.33840457
45MAPK131.32021674
46MAP3K111.31230794
47PTK21.30068997
48MAP3K91.27669577
49TTK1.26833495
50TAOK31.25755408
51TAOK21.25755245
52TRPM71.25103421
53MAP3K141.17077807
54FES1.14191845
55ZAP701.12553182
56PAK61.11340461
57ICK1.09204535
58PAK41.08902528
59LMTK21.08723289
60PINK11.08593988
61MAP3K41.07291236
62PRKG21.04955225
63STK381.03683068
64IKBKB0.96928391
65RAF10.92787674
66PRKD20.91166128
67RET0.89573737
68BLK0.88952167
69SIK30.87080260
70PIK3CA0.87010797
71BMPR20.86182629
72OBSCN0.84646993
73MET0.80227145
74TGFBR10.80200910
75FLT30.80138434
76CHUK0.79074487
77ACVR1B0.78253942
78RPS6KA20.77869072
79TYK20.77344558
80MST1R0.76748196
81STK30.76282941
82STK100.74758748
83TEC0.74523946
84CSK0.73149251
85ARAF0.72907136
86MAP3K130.72714540
87PRKAA10.72593549
88KIT0.70929789
89NEK90.69099656
90MAP3K10.68419178
91MAPK70.65456360
92JAK30.65254739
93EPHB10.65115096
94NTRK30.65035864
95PDGFRB0.64880892
96MELK0.62994488
97ROCK10.62641874
98BCKDK0.62129328
99MAP2K60.60263800
100PDK20.59665323
101CSF1R0.57306165
102MATK0.57214097
103DAPK30.56780479
104CDK90.56365093
105PAK30.55492315
106MAP2K10.54669495
107CAMK2A0.54514545
108NEK60.54293463
109MAP4K10.54154826
110MAPK150.54128874
111FGR0.53078316
112ADRBK10.51828651
113MAPK120.51754560
114BMPR1B0.51018219
115CSNK1G10.50932546
116TNK20.50924903
117TYRO30.50463827
118MAP2K40.50396344
119NTRK20.49726479
120PTK2B0.49310735
121MAP4K20.48361597
122TGFBR20.48157062
123PKN10.46361259
124ABL20.45985762
125GRK50.45938537
126CSNK1G30.45587431
127MAP2K70.45557379
128DYRK20.44642962
129ILK0.43728641
130MAPK40.43443101
131BMX0.42663828
132EPHA20.42443942
133PRKD10.41089295
134STK110.41002331
135KDR0.39765717
136CSNK1G20.39747243
137CHEK20.37602090
138PIK3CG0.37524030
139HCK0.37054188
140PAK10.36044444
141RPS6KA60.35261092
142RPS6KL10.34283720
143RPS6KC10.34283720
144PAK20.33707170
145MARK20.32317949
146GSK3A0.32020201
147IKBKE0.31689106
148GRK10.31310098
149LCK0.30038132
150ROCK20.29988862
151PRKCE0.29504349
152FER0.28734364
153IGF1R0.27108361
154PRKACB0.26103988
155DDR20.25664757
156PRKCH0.25508579
157PRKACA0.24720670
158MAP3K50.23063456
159ABL10.22952109
160CDC42BPA0.22614390
161TRIB30.22413182
162PDK30.22383326
163PDK40.22383326
164SGK2230.21846058

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.59070448
2Ovarian steroidogenesis_Homo sapiens_hsa049133.33649609
3Lysosome_Homo sapiens_hsa041423.27700565
4Dilated cardiomyopathy_Homo sapiens_hsa054142.72643178
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.57974085
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.48109456
7Rheumatoid arthritis_Homo sapiens_hsa053232.37092095
8Dorso-ventral axis formation_Homo sapiens_hsa043202.30547119
9Circadian rhythm_Homo sapiens_hsa047102.18714628
10Pertussis_Homo sapiens_hsa051332.14210454
11Other glycan degradation_Homo sapiens_hsa005112.13989220
12GnRH signaling pathway_Homo sapiens_hsa049122.13973710
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00957388
14TNF signaling pathway_Homo sapiens_hsa046681.89464930
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84118208
16Osteoclast differentiation_Homo sapiens_hsa043801.78170784
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71796685
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68645760
19Salmonella infection_Homo sapiens_hsa051321.59438103
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.59323170
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58827788
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57950213
23Staphylococcus aureus infection_Homo sapiens_hsa051501.53342621
24Complement and coagulation cascades_Homo sapiens_hsa046101.49649327
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48795177
26Cardiac muscle contraction_Homo sapiens_hsa042601.47113109
27Gap junction_Homo sapiens_hsa045401.46059071
28African trypanosomiasis_Homo sapiens_hsa051431.43739711
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41613154
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40214956
31Cocaine addiction_Homo sapiens_hsa050301.36444405
32ECM-receptor interaction_Homo sapiens_hsa045121.33671964
33RNA degradation_Homo sapiens_hsa030181.33537081
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33277117
35Tuberculosis_Homo sapiens_hsa051521.33108090
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.32541834
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29542658
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29108155
39Gastric acid secretion_Homo sapiens_hsa049711.27036405
40Shigellosis_Homo sapiens_hsa051311.26217697
41Toxoplasmosis_Homo sapiens_hsa051451.25854799
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25829661
43Renin secretion_Homo sapiens_hsa049241.25078457
44TGF-beta signaling pathway_Homo sapiens_hsa043501.24549630
45Phagosome_Homo sapiens_hsa041451.24422860
46Prion diseases_Homo sapiens_hsa050201.22010799
47Cholinergic synapse_Homo sapiens_hsa047251.21893885
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20628996
49Fatty acid metabolism_Homo sapiens_hsa012121.20375237
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20164006
51Oxytocin signaling pathway_Homo sapiens_hsa049211.19950330
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.19423702
53Leishmaniasis_Homo sapiens_hsa051401.18780358
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18711986
55MicroRNAs in cancer_Homo sapiens_hsa052061.17365758
56Bladder cancer_Homo sapiens_hsa052191.16921561
57Notch signaling pathway_Homo sapiens_hsa043301.15516225
58Legionellosis_Homo sapiens_hsa051341.15298813
59Glutamatergic synapse_Homo sapiens_hsa047241.13911380
60Pancreatic cancer_Homo sapiens_hsa052121.13833691
61Long-term depression_Homo sapiens_hsa047301.13278451
62Vitamin B6 metabolism_Homo sapiens_hsa007501.12370441
63Renal cell carcinoma_Homo sapiens_hsa052111.10814358
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10808820
65Fatty acid degradation_Homo sapiens_hsa000711.10496974
66Tyrosine metabolism_Homo sapiens_hsa003501.10425007
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09283888
68Asthma_Homo sapiens_hsa053101.08730822
69Sphingolipid metabolism_Homo sapiens_hsa006001.08683256
70Focal adhesion_Homo sapiens_hsa045101.08647974
71Malaria_Homo sapiens_hsa051441.07913360
72Ether lipid metabolism_Homo sapiens_hsa005651.07114976
73Choline metabolism in cancer_Homo sapiens_hsa052311.05864969
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05803142
75Hematopoietic cell lineage_Homo sapiens_hsa046401.04165248
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04103939
77Estrogen signaling pathway_Homo sapiens_hsa049151.03395624
78Phenylalanine metabolism_Homo sapiens_hsa003601.02349397
79Serotonergic synapse_Homo sapiens_hsa047260.99916373
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.99488511
81Oocyte meiosis_Homo sapiens_hsa041140.97646884
82Propanoate metabolism_Homo sapiens_hsa006400.96805661
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.95142025
84Vibrio cholerae infection_Homo sapiens_hsa051100.94565560
85Linoleic acid metabolism_Homo sapiens_hsa005910.94111927
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93024180
87Prolactin signaling pathway_Homo sapiens_hsa049170.92726008
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91754166
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89906897
90cAMP signaling pathway_Homo sapiens_hsa040240.89281902
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87948687
92Influenza A_Homo sapiens_hsa051640.87874424
93Circadian entrainment_Homo sapiens_hsa047130.87777863
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.87370171
95Salivary secretion_Homo sapiens_hsa049700.86792159
96Fatty acid biosynthesis_Homo sapiens_hsa000610.86217153
97Cell cycle_Homo sapiens_hsa041100.86112686
98Arginine and proline metabolism_Homo sapiens_hsa003300.85788201
99Allograft rejection_Homo sapiens_hsa053300.84842192
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84350646
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84341158
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83568220
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82947352
104Calcium signaling pathway_Homo sapiens_hsa040200.82147637
105Insulin secretion_Homo sapiens_hsa049110.82115476
106Collecting duct acid secretion_Homo sapiens_hsa049660.82072287
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80834162
108Platelet activation_Homo sapiens_hsa046110.80028870
109Glucagon signaling pathway_Homo sapiens_hsa049220.79833931
110Amphetamine addiction_Homo sapiens_hsa050310.78590458
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76974564
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74941919
113Tight junction_Homo sapiens_hsa045300.74562968
114Ras signaling pathway_Homo sapiens_hsa040140.74481832
115Glioma_Homo sapiens_hsa052140.73872772
116Bile secretion_Homo sapiens_hsa049760.73735554
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72837861
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71409601
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.69167329
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69122083
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69049296
122Adherens junction_Homo sapiens_hsa045200.68653544
123Axon guidance_Homo sapiens_hsa043600.68530378
124MAPK signaling pathway_Homo sapiens_hsa040100.67779020
125Proteoglycans in cancer_Homo sapiens_hsa052050.67741629
126Nicotine addiction_Homo sapiens_hsa050330.66802104
127Sulfur metabolism_Homo sapiens_hsa009200.65483555
128Olfactory transduction_Homo sapiens_hsa047400.65045446
129Apoptosis_Homo sapiens_hsa042100.64621863
130Basal transcription factors_Homo sapiens_hsa030220.63953548
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.63327601
132Dopaminergic synapse_Homo sapiens_hsa047280.63081316
133Histidine metabolism_Homo sapiens_hsa003400.62865808
134VEGF signaling pathway_Homo sapiens_hsa043700.60247841
135Arginine biosynthesis_Homo sapiens_hsa002200.60095362
136Graft-versus-host disease_Homo sapiens_hsa053320.59462897
137Insulin signaling pathway_Homo sapiens_hsa049100.58374571
138Hippo signaling pathway_Homo sapiens_hsa043900.58121210
139Hepatitis C_Homo sapiens_hsa051600.57741927
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.57193716
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.56184752
142PPAR signaling pathway_Homo sapiens_hsa033200.54959750
143Endocytosis_Homo sapiens_hsa041440.54023074
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53808304
145Non-homologous end-joining_Homo sapiens_hsa034500.53045897
146Amoebiasis_Homo sapiens_hsa051460.52793546
147Melanoma_Homo sapiens_hsa052180.52788866
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52672876
149Morphine addiction_Homo sapiens_hsa050320.51544429
150Hepatitis B_Homo sapiens_hsa051610.51241715
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50825107
152HIF-1 signaling pathway_Homo sapiens_hsa040660.50637869
153Viral myocarditis_Homo sapiens_hsa054160.50491524
154Mineral absorption_Homo sapiens_hsa049780.50170791
155Fatty acid elongation_Homo sapiens_hsa000620.49861589
156Protein digestion and absorption_Homo sapiens_hsa049740.49716276
157Rap1 signaling pathway_Homo sapiens_hsa040150.49629931
158Acute myeloid leukemia_Homo sapiens_hsa052210.46637518
159N-Glycan biosynthesis_Homo sapiens_hsa005100.46020751
160Glutathione metabolism_Homo sapiens_hsa004800.42648077
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41843300
162Autoimmune thyroid disease_Homo sapiens_hsa053200.37929944
163Chemokine signaling pathway_Homo sapiens_hsa040620.37673812
164Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35097945
165Measles_Homo sapiens_hsa051620.34413409
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.32968418
167Synaptic vesicle cycle_Homo sapiens_hsa047210.32773172
168ABC transporters_Homo sapiens_hsa020100.32184196
169Antigen processing and presentation_Homo sapiens_hsa046120.30053121
170Herpes simplex infection_Homo sapiens_hsa051680.28546524
171Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26896919

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »