TMEM256-PLSCR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07651805
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72651241
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67289505
4negative regulation of cell killing (GO:0031342)4.67289505
5antigen processing and presentation of endogenous antigen (GO:0019883)4.61865464
6leukocyte aggregation (GO:0070486)4.25877601
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22854016
8negative T cell selection (GO:0043383)4.20688098
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15211571
10negative thymic T cell selection (GO:0045060)4.06369748
11NIK/NF-kappaB signaling (GO:0038061)4.05406821
12thymic T cell selection (GO:0045061)4.02447730
13negative regulation of phagocytosis (GO:0050765)3.76938366
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.74890679
15positive regulation of gamma-delta T cell activation (GO:0046645)3.70605700
16regulation of T cell tolerance induction (GO:0002664)3.57019276
17T cell selection (GO:0045058)3.50512091
18positive thymic T cell selection (GO:0045059)3.44763565
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43723907
20tolerance induction (GO:0002507)3.43186792
21barbed-end actin filament capping (GO:0051016)3.25169985
22hemidesmosome assembly (GO:0031581)3.18797526
23regulation of defense response to virus by virus (GO:0050690)3.13661838
24positive T cell selection (GO:0043368)3.11096871
25response to interleukin-15 (GO:0070672)3.05662412
26positive regulation by symbiont of host defense response (GO:0052509)3.02935588
27modulation by symbiont of host defense response (GO:0052031)3.02935588
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02935588
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02935588
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.02935588
31modulation by symbiont of host immune response (GO:0052553)3.02935588
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02837744
33positive regulation of tolerance induction (GO:0002645)3.00191211
34regulation of natural killer cell mediated immunity (GO:0002715)2.99177303
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99177303
36negative regulation of stress fiber assembly (GO:0051497)2.98966832
37cellular response to interleukin-15 (GO:0071350)2.97465957
38regulation of extracellular matrix disassembly (GO:0010715)2.93761917
39skin morphogenesis (GO:0043589)2.88558394
40protein heterotrimerization (GO:0070208)2.88339464
41signal complex assembly (GO:0007172)2.87913906
42T cell migration (GO:0072678)2.87761804
43regulation of B cell receptor signaling pathway (GO:0050855)2.86397296
44mannose metabolic process (GO:0006013)2.86307693
45regulation of tolerance induction (GO:0002643)2.83924923
46positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82844625
47membrane raft organization (GO:0031579)2.82579427
48regulation of T cell mediated cytotoxicity (GO:0001914)2.82085634
49cell-substrate junction assembly (GO:0007044)2.81854007
50regulation of interleukin-2 biosynthetic process (GO:0045076)2.81195733
51type I interferon signaling pathway (GO:0060337)2.79432947
52cellular response to type I interferon (GO:0071357)2.79432947
53response to type I interferon (GO:0034340)2.76705222
54fibril organization (GO:0097435)2.75143223
55antigen processing and presentation via MHC class Ib (GO:0002475)2.74137081
56positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74132986
57detection of bacterium (GO:0016045)2.73757758
58regulation of gamma-delta T cell activation (GO:0046643)2.68889772
59stress fiber assembly (GO:0043149)2.68869222
60response to laminar fluid shear stress (GO:0034616)2.68708154
61negative regulation of erythrocyte differentiation (GO:0045647)2.68670130
62regulation of gamma-delta T cell differentiation (GO:0045586)2.68636480
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66176980
64positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.65968292
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62653560
66response to muramyl dipeptide (GO:0032495)2.62279725
67type B pancreatic cell proliferation (GO:0044342)2.61352011
68detection of other organism (GO:0098543)2.60703932
69negative regulation of T cell mediated immunity (GO:0002710)2.60190338
70endodermal cell differentiation (GO:0035987)2.59325885
71negative regulation of interleukin-12 production (GO:0032695)2.58898232
72protein localization to endosome (GO:0036010)2.58389628
73negative regulation of leukocyte mediated immunity (GO:0002704)2.57400017
74positive regulation of natural killer cell differentiation (GO:0032825)2.57233136
75T cell receptor signaling pathway (GO:0050852)2.55177764
76regulation of necroptotic process (GO:0060544)2.52323077
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.51331369
78positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51003458
79regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48563232
80negative regulation of nitric oxide biosynthetic process (GO:0045019)2.47261801
81substrate-dependent cell migration (GO:0006929)2.47260595
82regulation of leukocyte mediated cytotoxicity (GO:0001910)2.44043381
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.43846659
84pinocytosis (GO:0006907)2.43053543
85T cell homeostasis (GO:0043029)2.42718196
86regulation of regulatory T cell differentiation (GO:0045589)2.41750369
87lymph node development (GO:0048535)2.41447086
88angiogenesis involved in wound healing (GO:0060055)2.41387230
89negative regulation of smooth muscle cell migration (GO:0014912)2.39829896
90positive regulation of interleukin-8 secretion (GO:2000484)2.39352772
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.38673880
92positive regulation of natural killer cell mediated immunity (GO:0002717)2.38184436
93lymphocyte migration (GO:0072676)2.37648639
94cell migration involved in heart development (GO:0060973)2.35993958
95focal adhesion assembly (GO:0048041)2.35865268
96cell-substrate adherens junction assembly (GO:0007045)2.35865268
97blood vessel maturation (GO:0001955)2.35021090
98regulation of B cell differentiation (GO:0045577)2.33987037
99extracellular fibril organization (GO:0043206)2.33771916
100T cell costimulation (GO:0031295)2.30596642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.29337831
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.27905740
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.23155462
4ELK3_25401928_ChIP-Seq_HUVEC_Human3.01357809
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58424653
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.57175032
7VDR_21846776_ChIP-Seq_THP-1_Human2.53389642
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.52388602
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52220109
10LXR_22292898_ChIP-Seq_THP-1_Human2.41223803
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28858137
12MYC_22102868_ChIP-Seq_BL_Human2.24814887
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21671375
14MAF_26560356_Chip-Seq_TH1_Human2.15177877
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11006559
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09303998
17KDM2B_26808549_Chip-Seq_DND41_Human2.05095390
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03378927
19UTX_26944678_Chip-Seq_JUKART_Human2.01532218
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00777229
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94982067
22MAF_26560356_Chip-Seq_TH2_Human1.94198399
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93817581
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92506504
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85062542
26VDR_24763502_ChIP-Seq_THP-1_Human1.83188307
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77978679
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77778176
29TCF7_22412390_ChIP-Seq_EML_Mouse1.75143621
30RACK7_27058665_Chip-Seq_MCF-7_Human1.74742053
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.69778040
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65697771
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57496799
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54762369
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.51015689
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49591516
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49543293
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.48619562
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47045669
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46795695
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45313423
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45286123
43RUNX_20019798_ChIP-Seq_JUKART_Human1.43982368
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.43977615
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40501272
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.39188494
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38273191
48MYB_26560356_Chip-Seq_TH2_Human1.36788774
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36601788
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.34518474
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33768271
52SPI1_23547873_ChIP-Seq_NB4_Human1.32258975
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31413667
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30685088
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30523150
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.30117606
57TP53_22127205_ChIP-Seq_IMR90_Human1.29445799
58MYB_26560356_Chip-Seq_TH1_Human1.29135233
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28472423
60P68_20966046_ChIP-Seq_HELA_Human1.27607262
61BCL6_27268052_Chip-Seq_Bcells_Human1.27460216
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25471440
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23469714
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.23021813
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21219574
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20116164
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19693136
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19483390
69SPI1_23127762_ChIP-Seq_K562_Human1.19370292
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19285738
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19184163
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19015349
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17967444
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17508709
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17009631
76ATF3_27146783_Chip-Seq_COLON_Human1.16897127
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15391317
78BCOR_27268052_Chip-Seq_Bcells_Human1.14742558
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13944092
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12806838
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12736700
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12350327
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.11375905
84KDM2B_26808549_Chip-Seq_K562_Human1.11342718
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10884033
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10756131
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08661765
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07274189
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.07234235
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06673117
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04145726
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03080723
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02626711
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02048182
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01442232
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00997768
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00704263
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.00678262
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00105547
100NCOR1_26117541_ChIP-Seq_K562_Human1.00080854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.26231776
2MP0003705_abnormal_hypodermis_morpholog3.32236715
3MP0003279_aneurysm3.11532679
4MP0003436_decreased_susceptibility_to3.07595545
5MP0003763_abnormal_thymus_physiology2.64682373
6MP0001958_emphysema2.55083339
7MP0003566_abnormal_cell_adhesion2.39784647
8MP0005275_abnormal_skin_tensile2.30793240
9MP0000685_abnormal_immune_system2.20960853
10MP0005503_abnormal_tendon_morphology2.13992991
11MP0001542_abnormal_bone_strength2.13351639
12MP0009333_abnormal_splenocyte_physiolog2.06410127
13MP0005671_abnormal_response_to2.05561508
14MP0001835_abnormal_antigen_presentation2.01423844
15MP0003300_gastrointestinal_ulcer1.99494280
16MP0004272_abnormal_basement_membrane1.99158082
17MP0005000_abnormal_immune_tolerance1.98130999
18MP0001348_abnormal_lacrimal_gland1.96977989
19MP0006082_CNS_inflammation1.95715953
20MP0003724_increased_susceptibility_to1.93952824
21MP0003191_abnormal_cellular_cholesterol1.86953560
22MP0005387_immune_system_phenotype1.80910448
23MP0001790_abnormal_immune_system1.80910448
24MP0001533_abnormal_skeleton_physiology1.79827481
25MP0004947_skin_inflammation1.79454926
26MP0005025_abnormal_response_to1.77012682
27MP0002933_joint_inflammation1.73957213
28MP0003091_abnormal_cell_migration1.71297818
29MP0005023_abnormal_wound_healing1.70999674
30MP0001800_abnormal_humoral_immune1.68630794
31MP0008260_abnormal_autophagy1.68307941
32MP0000858_altered_metastatic_potential1.67662314
33MP0009384_cardiac_valve_regurgitation1.65310975
34MP0002420_abnormal_adaptive_immunity1.65213991
35MP0002723_abnormal_immune_serum1.63619496
36MP0002419_abnormal_innate_immunity1.63565555
37MP0001819_abnormal_immune_cell1.62352428
38MP0000767_abnormal_smooth_muscle1.58881990
39MP0005257_abnormal_intraocular_pressure1.56214783
40MP0001849_ear_inflammation1.53727559
41MP0010368_abnormal_lymphatic_system1.51938571
42MP0002060_abnormal_skin_morphology1.51219259
43MP0002148_abnormal_hypersensitivity_rea1.50618837
44MP0005451_abnormal_body_composition1.50478106
45MP0009785_altered_susceptibility_to1.50008301
46MP0002452_abnormal_antigen_presenting1.48637666
47MP0005058_abnormal_lysosome_morphology1.47484050
48MP0002405_respiratory_system_inflammati1.45915688
49MP0005390_skeleton_phenotype1.40470803
50MP0002254_reproductive_system_inflammat1.36559012
51MP0005464_abnormal_platelet_physiology1.30945452
52MP0003448_altered_tumor_morphology1.30841343
53MP0002398_abnormal_bone_marrow1.28005296
54MP0010155_abnormal_intestine_physiology1.26345385
55MP0005623_abnormal_meninges_morphology1.24157456
56MP0003828_pulmonary_edema1.24091757
57MP0000703_abnormal_thymus_morphology1.23984693
58MP0000716_abnormal_immune_system1.23903351
59MP0000751_myopathy1.22558675
60MP0006054_spinal_hemorrhage1.22153299
61MP0001873_stomach_inflammation1.18543360
62MP0004381_abnormal_hair_follicle1.18331186
63MP0004510_myositis1.17605611
64MP0002998_abnormal_bone_remodeling1.17523955
65MP0003866_abnormal_defecation1.08574903
66MP0004858_abnormal_nervous_system1.07302068
67MP0001243_abnormal_dermal_layer1.06128348
68MP0009840_abnormal_foam_cell1.05763837
69MP0001851_eye_inflammation1.05723079
70MP0000465_gastrointestinal_hemorrhage1.05424742
71MP0002722_abnormal_immune_system1.05134366
72MP0000750_abnormal_muscle_regeneration1.02638673
73MP0003303_peritoneal_inflammation1.01513885
74MP0002429_abnormal_blood_cell1.01246513
75MP0001845_abnormal_inflammatory_respons1.00135994
76MP0000689_abnormal_spleen_morphology0.98265808
77MP0004883_abnormal_blood_vessel0.97811070
78MP0005508_abnormal_skeleton_morphology0.95737141
79MP0003172_abnormal_lysosome_physiology0.95462151
80MP0005164_abnormal_response_to0.95213829
81MP0000733_abnormal_muscle_development0.92444372
82MP0002877_abnormal_melanocyte_morpholog0.91558593
83MP0003045_fibrosis0.91082202
84MP0002295_abnormal_pulmonary_circulatio0.90473888
85MP0003453_abnormal_keratinocyte_physiol0.89990069
86MP0003795_abnormal_bone_structure0.89514122
87MP0000490_abnormal_crypts_of0.86014973
88MP0002796_impaired_skin_barrier0.84936498
89MP0008469_abnormal_protein_level0.82493982
90MP0000759_abnormal_skeletal_muscle0.79078726
91MP0005595_abnormal_vascular_smooth0.77367101
92MP0000343_altered_response_to0.76956194
93MP0000249_abnormal_blood_vessel0.76092613
94MP0000749_muscle_degeneration0.75598602
95MP0001853_heart_inflammation0.75488337
96MP0001216_abnormal_epidermal_layer0.74976590
97MP0009053_abnormal_anal_canal0.74383989
98MP0010030_abnormal_orbit_morphology0.74245903
99MP0009931_abnormal_skin_appearance0.73627020
100MP0002108_abnormal_muscle_morphology0.72476615

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.31464829
2Protrusio acetabuli (HP:0003179)5.04846884
3Elevated erythrocyte sedimentation rate (HP:0003565)3.89741355
4Aortic aneurysm (HP:0004942)3.72403936
5Atrophic scars (HP:0001075)3.65783316
6Aortic dissection (HP:0002647)3.47896618
7Peritonitis (HP:0002586)3.35990988
8Eczematoid dermatitis (HP:0000976)3.21679636
9Cervical subluxation (HP:0003308)3.21250077
10Fragile skin (HP:0001030)3.13212003
11Dilatation of the ascending aorta (HP:0005111)3.13004787
12Vascular tortuosity (HP:0004948)3.06057500
13Spondylolisthesis (HP:0003302)2.96609252
14Genu recurvatum (HP:0002816)2.95910745
15Ankle contracture (HP:0006466)2.93670018
16Vertebral compression fractures (HP:0002953)2.91092250
17Spinal rigidity (HP:0003306)2.84640492
18Increased variability in muscle fiber diameter (HP:0003557)2.79071454
19Slender build (HP:0001533)2.76851613
20Myositis (HP:0100614)2.75735842
21Joint stiffness (HP:0001387)2.72371940
22Abnormality of macrophages (HP:0004311)2.71209985
23Arterial tortuosity (HP:0005116)2.70129493
24Type 1 muscle fiber predominance (HP:0003803)2.67728570
25Abnormality of skeletal muscle fiber size (HP:0012084)2.63925400
26Blue sclerae (HP:0000592)2.55187351
27Pustule (HP:0200039)2.54426738
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.52811633
29Increased IgE level (HP:0003212)2.52357083
30Cerebral aneurysm (HP:0004944)2.50557326
31Easy fatigability (HP:0003388)2.43350833
32Bladder diverticulum (HP:0000015)2.38599086
33Increased connective tissue (HP:0009025)2.32616147
34Follicular hyperkeratosis (HP:0007502)2.31959606
35Biconcave vertebral bodies (HP:0004586)2.30175202
36Increased IgM level (HP:0003496)2.25879281
37Generalized amyotrophy (HP:0003700)2.25446831
38Wormian bones (HP:0002645)2.25359361
39Cellulitis (HP:0100658)2.23781298
40Recurrent abscess formation (HP:0002722)2.23043107
41Soft skin (HP:0000977)2.21540745
42Recurrent fungal infections (HP:0002841)2.21218156
43Stomatitis (HP:0010280)2.20338306
44Recurrent bacterial skin infections (HP:0005406)2.20287764
45Mitral regurgitation (HP:0001653)2.19512194
46Broad face (HP:0000283)2.18737269
47Distal lower limb muscle weakness (HP:0009053)2.18375361
48Emphysema (HP:0002097)2.16960646
49Aortic regurgitation (HP:0001659)2.14389341
50Aneurysm (HP:0002617)2.13142545
51T lymphocytopenia (HP:0005403)2.09827096
52Milia (HP:0001056)2.08332984
53Abnormality of T cell number (HP:0011839)2.07944259
54Reduced subcutaneous adipose tissue (HP:0003758)2.07758774
55Thin bony cortex (HP:0002753)2.06991197
56Hypergammaglobulinemia (HP:0010702)2.05208496
57Disproportionate tall stature (HP:0001519)2.04296622
58Orchitis (HP:0100796)2.03961239
59Spontaneous hematomas (HP:0007420)2.01850036
60Dysostosis multiplex (HP:0000943)2.00261377
61Abnormality of dentin (HP:0010299)2.00198059
62Joint laxity (HP:0001388)1.99024400
63Elbow flexion contracture (HP:0002987)1.98150654
64Broad metatarsal (HP:0001783)1.97814445
65Achilles tendon contracture (HP:0001771)1.96597694
66Ulnar deviation of the wrist (HP:0003049)1.96513569
67Shallow orbits (HP:0000586)1.95839838
68Centrally nucleated skeletal muscle fibers (HP:0003687)1.93940798
69Mitral valve prolapse (HP:0001634)1.91224125
70Mildly elevated creatine phosphokinase (HP:0008180)1.89591229
71Panhypogammaglobulinemia (HP:0003139)1.88703514
72Granulocytopenia (HP:0001913)1.88118615
73Mediastinal lymphadenopathy (HP:0100721)1.87935905
74Gastrointestinal infarctions (HP:0005244)1.84968174
75Upper limb amyotrophy (HP:0009129)1.81455183
76Distal upper limb amyotrophy (HP:0007149)1.81455183
77Nail dystrophy (HP:0008404)1.81301576
78Gastrointestinal inflammation (HP:0004386)1.80843590
79Thick nail (HP:0001805)1.80634116
80Recurrent cutaneous fungal infections (HP:0011370)1.80560583
81Chronic mucocutaneous candidiasis (HP:0002728)1.80560583
82Urticaria (HP:0001025)1.79122793
83Aortic valve stenosis (HP:0001650)1.77578119
84Asymmetric septal hypertrophy (HP:0001670)1.76695703
85Stridor (HP:0010307)1.75578740
86Recurrent skin infections (HP:0001581)1.75255537
87Autoimmune hemolytic anemia (HP:0001890)1.74677827
88Pulmonary infiltrates (HP:0002113)1.74469104
89Recurrent viral infections (HP:0004429)1.74078832
90Leukocytosis (HP:0001974)1.73468235
91Long palpebral fissure (HP:0000637)1.73311793
92Difficulty climbing stairs (HP:0003551)1.73279380
93Meningitis (HP:0001287)1.72860668
94Papilloma (HP:0012740)1.72201089
95Verrucae (HP:0200043)1.72201089
96Petechiae (HP:0000967)1.71822486
97Distal lower limb amyotrophy (HP:0008944)1.70372760
98Nonimmune hydrops fetalis (HP:0001790)1.70268036
99Gastrointestinal dysmotility (HP:0002579)1.70178085
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68700698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.51445865
2ERN13.13860329
3EPHB12.82813933
4TESK22.58463920
5TRIB32.51790732
6PRPF4B2.36229970
7TESK12.20637760
8SIK12.16983417
9ZAP702.12090541
10MAP2K32.07505210
11KDR1.92204713
12PRKD21.90323862
13TGFBR21.89016397
14TTN1.81264711
15TYK21.76004685
16MYLK1.75219883
17GRK61.74207084
18MAP3K101.72795558
19SMG11.70099350
20MAP3K111.69600658
21MAP3K31.62744026
22CSK1.59163905
23NME21.55603501
24PAK41.54334238
25TXK1.47917930
26JAK31.47552179
27FES1.42003224
28BTK1.33829290
29TBK11.33090810
30TAOK21.28937992
31SIK31.27590588
32PTK21.21809547
33PDGFRA1.20493519
34IRAK41.19626134
35LIMK11.17722045
36CDC42BPA1.16569327
37NTRK11.13205700
38ITK1.11126821
39TAOK11.09653210
40RIPK41.08742702
41STK381.07749377
42PTK61.06344728
43MAP3K131.04122861
44EPHB21.01495600
45PKN21.01476163
46MOS0.99449073
47HCK0.98473406
48RIPK10.98117664
49STK100.96846364
50TNK20.94789637
51IRAK30.94737158
52ICK0.92450553
53LCK0.91522852
54LRRK20.90484222
55ARAF0.90185215
56HIPK20.90090351
57MARK20.89306159
58RPS6KA20.87544160
59FGFR40.86424662
60MAP3K10.84793843
61IKBKE0.84585698
62JAK10.82520334
63EPHA20.81813869
64PTK2B0.79905837
65PIM20.77828338
66MARK30.76663535
67IKBKB0.76636664
68ILK0.74061855
69MAPK70.71560901
70VRK20.71267774
71RPS6KL10.70503242
72RPS6KC10.70503242
73BLK0.69270221
74DDR20.69208898
75MAP3K60.67914381
76SYK0.66728534
77MAPKAPK20.65763192
78FLT30.61769804
79MAPK120.60502977
80MAP3K140.60185501
81MAPKAPK30.58717480
82CSF1R0.55942428
83TIE10.55675542
84MAP3K70.55473926
85PRKG20.54889142
86KIT0.54704612
87ABL20.52781591
88RPS6KA60.51635139
89PDGFRB0.50992392
90CLK10.50497517
91PAK10.49708524
92MUSK0.49652211
93BMX0.49287613
94PRKCQ0.48522053
95PRKD30.48184310
96SIK20.47458094
97DYRK1B0.45382183
98PRKD10.44209627
99PAK20.43501506
100LYN0.42608906

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.85808031
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.60880341
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13047077
4T cell receptor signaling pathway_Homo sapiens_hsa046602.08678837
5Osteoclast differentiation_Homo sapiens_hsa043801.95400957
6Acute myeloid leukemia_Homo sapiens_hsa052211.86205252
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.82406843
8Malaria_Homo sapiens_hsa051441.81795851
9Other glycan degradation_Homo sapiens_hsa005111.81238893
10Allograft rejection_Homo sapiens_hsa053301.74956429
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.70251344
12Shigellosis_Homo sapiens_hsa051311.67023131
13Viral myocarditis_Homo sapiens_hsa054161.66510742
14Focal adhesion_Homo sapiens_hsa045101.66366203
15Graft-versus-host disease_Homo sapiens_hsa053321.64694310
16Measles_Homo sapiens_hsa051621.63898874
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61320540
18Autoimmune thyroid disease_Homo sapiens_hsa053201.60020896
19Hematopoietic cell lineage_Homo sapiens_hsa046401.57940959
20B cell receptor signaling pathway_Homo sapiens_hsa046621.52290119
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.50741508
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.49519729
23ECM-receptor interaction_Homo sapiens_hsa045121.47290972
24Leishmaniasis_Homo sapiens_hsa051401.44968643
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39059089
26Notch signaling pathway_Homo sapiens_hsa043301.31481619
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31434962
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31037451
29Toxoplasmosis_Homo sapiens_hsa051451.30992945
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29183498
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28325779
32TNF signaling pathway_Homo sapiens_hsa046681.28119874
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27608310
34VEGF signaling pathway_Homo sapiens_hsa043701.27293734
35Antigen processing and presentation_Homo sapiens_hsa046121.23729466
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21584474
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20892925
38Apoptosis_Homo sapiens_hsa042101.20868831
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19590648
40Amoebiasis_Homo sapiens_hsa051461.17832214
41Endocytosis_Homo sapiens_hsa041441.17570234
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16380786
43Hepatitis B_Homo sapiens_hsa051611.15432336
44Non-small cell lung cancer_Homo sapiens_hsa052231.10404257
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08837953
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08615643
47Salmonella infection_Homo sapiens_hsa051321.08514356
48Proteoglycans in cancer_Homo sapiens_hsa052051.06924709
49Chemokine signaling pathway_Homo sapiens_hsa040621.05668200
50Tuberculosis_Homo sapiens_hsa051521.05426843
51Pancreatic cancer_Homo sapiens_hsa052121.05034958
52Platelet activation_Homo sapiens_hsa046111.03452079
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.01420145
54Herpes simplex infection_Homo sapiens_hsa051680.98725028
55HTLV-I infection_Homo sapiens_hsa051660.97305423
56Phagosome_Homo sapiens_hsa041450.96743987
57Bladder cancer_Homo sapiens_hsa052190.96156486
58Influenza A_Homo sapiens_hsa051640.95980481
59Small cell lung cancer_Homo sapiens_hsa052220.92485770
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.91204024
61Pertussis_Homo sapiens_hsa051330.90906915
62Endometrial cancer_Homo sapiens_hsa052130.89235695
63Thyroid cancer_Homo sapiens_hsa052160.87578952
64Lysosome_Homo sapiens_hsa041420.86861119
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83251029
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83238008
67Hepatitis C_Homo sapiens_hsa051600.83008849
68Type I diabetes mellitus_Homo sapiens_hsa049400.82479710
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.79033125
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76537908
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.76365813
72Colorectal cancer_Homo sapiens_hsa052100.75273640
73Renal cell carcinoma_Homo sapiens_hsa052110.74817336
74MAPK signaling pathway_Homo sapiens_hsa040100.73098886
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.73066719
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71998778
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.70128397
78Pathways in cancer_Homo sapiens_hsa052000.69260631
79Dilated cardiomyopathy_Homo sapiens_hsa054140.68372871
80Rap1 signaling pathway_Homo sapiens_hsa040150.66705975
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63568234
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63327349
83African trypanosomiasis_Homo sapiens_hsa051430.61388649
84Viral carcinogenesis_Homo sapiens_hsa052030.60875866
85Galactose metabolism_Homo sapiens_hsa000520.60034125
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59863754
87Staphylococcus aureus infection_Homo sapiens_hsa051500.59405191
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59011308
89Glioma_Homo sapiens_hsa052140.58541927
90Epstein-Barr virus infection_Homo sapiens_hsa051690.58529266
91Prostate cancer_Homo sapiens_hsa052150.54874867
92Ras signaling pathway_Homo sapiens_hsa040140.54415761
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53031867
94Axon guidance_Homo sapiens_hsa043600.51581397
95GnRH signaling pathway_Homo sapiens_hsa049120.51471829
96Legionellosis_Homo sapiens_hsa051340.51439312
97p53 signaling pathway_Homo sapiens_hsa041150.50833684
98Pentose phosphate pathway_Homo sapiens_hsa000300.50191931
99Adherens junction_Homo sapiens_hsa045200.48885526
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48365769

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