TMEM257

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.92334010
2postsynaptic membrane organization (GO:0001941)5.54634285
3presynaptic membrane organization (GO:0097090)5.47605905
4C4-dicarboxylate transport (GO:0015740)5.31963853
5positive regulation of potassium ion transmembrane transport (GO:1901381)5.01794702
6auditory behavior (GO:0031223)4.72906870
7gamma-aminobutyric acid transport (GO:0015812)4.65598223
8nonmotile primary cilium assembly (GO:0035058)4.52183716
9neuron cell-cell adhesion (GO:0007158)4.46913890
10neurotransmitter-gated ion channel clustering (GO:0072578)4.39500751
11startle response (GO:0001964)4.33714964
12membrane repolarization (GO:0086009)4.27507363
13mechanosensory behavior (GO:0007638)4.26998409
14membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.22887668
15potassium ion export (GO:0071435)4.18574631
16positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.13386513
17negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.07972718
18neuronal action potential propagation (GO:0019227)4.01972111
19membrane repolarization during action potential (GO:0086011)4.00413607
20response to auditory stimulus (GO:0010996)3.98800746
21cerebral cortex radially oriented cell migration (GO:0021799)3.82598223
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82552155
23positive regulation of potassium ion transport (GO:0043268)3.73690972
24oligodendrocyte differentiation (GO:0048709)3.69911302
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.69457732
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58893110
27glutamate receptor signaling pathway (GO:0007215)3.53255212
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47641796
29synapsis (GO:0007129)3.45010807
30regulation of potassium ion transmembrane transporter activity (GO:1901016)3.40164643
31regulation of membrane repolarization (GO:0060306)3.39232880
32cell morphogenesis involved in neuron differentiation (GO:0048667)3.34860442
33negative regulation of neurotransmitter transport (GO:0051589)3.34389137
34cellular response to cholesterol (GO:0071397)3.33916124
35amino acid import (GO:0043090)3.30639430
36spermatid nucleus differentiation (GO:0007289)3.28916869
37regulation of development, heterochronic (GO:0040034)3.28443853
38neurotransmitter uptake (GO:0001504)3.24504489
39central nervous system myelination (GO:0022010)3.22891255
40axon ensheathment in central nervous system (GO:0032291)3.22891255
41auditory receptor cell stereocilium organization (GO:0060088)3.19852725
42behavioral response to nicotine (GO:0035095)3.19658563
43regulation of timing of cell differentiation (GO:0048505)3.18226769
44regulation of cilium movement (GO:0003352)3.17437407
45synaptic transmission, glutamatergic (GO:0035249)3.15313630
46cellular response to sterol (GO:0036315)3.15275022
47forebrain neuron differentiation (GO:0021879)3.13465441
48vascular smooth muscle contraction (GO:0014829)3.12159550
49transmission of nerve impulse (GO:0019226)3.11315936
50righting reflex (GO:0060013)3.08605415
51L-amino acid import (GO:0043092)3.05582642
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.04506386
53pyrimidine nucleobase catabolic process (GO:0006208)3.03671903
54regulation of synapse structural plasticity (GO:0051823)3.03660894
55phenol-containing compound catabolic process (GO:0019336)3.03049092
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.02002009
57cerebellar granule cell differentiation (GO:0021707)3.00810269
58regulation of potassium ion transmembrane transport (GO:1901379)2.99965525
59acrosome assembly (GO:0001675)2.94785462
60platelet dense granule organization (GO:0060155)2.92268239
61regulation of heat generation (GO:0031650)2.91688501
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91464125
63vocalization behavior (GO:0071625)2.91209501
64retinal cone cell development (GO:0046549)2.91096012
65regulation of cardiac muscle cell contraction (GO:0086004)2.90150363
66cellular potassium ion homeostasis (GO:0030007)2.88798058
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86598863
68cellular sodium ion homeostasis (GO:0006883)2.86354852
69regulation of inclusion body assembly (GO:0090083)2.85762910
70acidic amino acid transport (GO:0015800)2.85313346
71neuron-neuron synaptic transmission (GO:0007270)2.84101631
72photoreceptor cell maintenance (GO:0045494)2.79641802
73neuronal stem cell maintenance (GO:0097150)2.78532428
74cellular response to leptin stimulus (GO:0044320)2.78412970
75positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77372326
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75748160
77gamma-aminobutyric acid signaling pathway (GO:0007214)2.72737839
78serotonin metabolic process (GO:0042428)2.72406825
79negative regulation of inclusion body assembly (GO:0090084)2.67451748
80protein localization to synapse (GO:0035418)2.65841533
81synaptic vesicle exocytosis (GO:0016079)2.61517603
82retinal rod cell development (GO:0046548)2.60600810
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60196091
84negative regulation of protein localization to cell surface (GO:2000009)2.58570802
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.55905482
86fatty acid elongation (GO:0030497)2.55504852
87cilium morphogenesis (GO:0060271)2.55176748
88neuromuscular synaptic transmission (GO:0007274)2.54671438
89regulation of dendritic spine morphogenesis (GO:0061001)2.53855613
90potassium ion import (GO:0010107)2.53470783
91prepulse inhibition (GO:0060134)2.52802643
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52238266
93astrocyte development (GO:0014002)2.51993175
94axonal fasciculation (GO:0007413)2.51645934
95negative regulation of adenylate cyclase activity (GO:0007194)2.51344834
96limb bud formation (GO:0060174)2.51203813
97inner ear receptor stereocilium organization (GO:0060122)2.50950628
98positive regulation of amino acid transport (GO:0051957)2.50668907
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50067640
100negative regulation of nucleotide biosynthetic process (GO:0030809)2.48502006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74419685
2GBX2_23144817_ChIP-Seq_PC3_Human4.30280351
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52660370
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95985403
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77551830
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55283194
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.42015884
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37648105
9ZNF274_21170338_ChIP-Seq_K562_Hela2.35265038
10TAF15_26573619_Chip-Seq_HEK293_Human2.34815710
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32346279
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.22785987
13P300_19829295_ChIP-Seq_ESCs_Human2.20510003
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.14400801
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06807389
16FUS_26573619_Chip-Seq_HEK293_Human2.04771838
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01533976
18EWS_26573619_Chip-Seq_HEK293_Human2.01068704
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98142776
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96701980
21VDR_22108803_ChIP-Seq_LS180_Human1.93910958
22IGF1R_20145208_ChIP-Seq_DFB_Human1.93017839
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91242981
24SMAD4_21799915_ChIP-Seq_A2780_Human1.90440968
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89262822
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.87113086
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78707434
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.77444147
29CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77064687
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74088480
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69008966
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.67516471
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67113575
34AR_25329375_ChIP-Seq_VCAP_Human1.66178739
35BCAT_22108803_ChIP-Seq_LS180_Human1.62929423
36REST_21632747_ChIP-Seq_MESCs_Mouse1.62134877
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59938034
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.59032768
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58424069
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56866896
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56707569
42STAT3_23295773_ChIP-Seq_U87_Human1.55680668
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55150536
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.54084586
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53284789
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51136047
47TP53_16413492_ChIP-PET_HCT116_Human1.49615006
48RNF2_27304074_Chip-Seq_NSC_Mouse1.48195647
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46068924
50ER_23166858_ChIP-Seq_MCF-7_Human1.43519502
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43086360
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42904018
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41456969
54TCF4_23295773_ChIP-Seq_U87_Human1.39352690
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.38776952
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37241044
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36851437
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35392673
59AR_21572438_ChIP-Seq_LNCaP_Human1.34322704
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34000214
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34000214
62RUNX2_22187159_ChIP-Seq_PCA_Human1.31814786
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28659785
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27758479
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.27336336
66SOX9_26525672_Chip-Seq_HEART_Mouse1.27044672
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26053780
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25366970
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25366970
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.25281076
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24778475
72TP53_18474530_ChIP-ChIP_U2OS_Human1.22177790
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21786964
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21679803
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21353366
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21352865
77CBP_20019798_ChIP-Seq_JUKART_Human1.21352865
78TCF4_22108803_ChIP-Seq_LS180_Human1.21225603
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.20587091
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20383847
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20085465
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20009271
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.18632799
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18591490
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17943037
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.15343178
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14993832
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13640215
89RXR_22108803_ChIP-Seq_LS180_Human1.13429208
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13250451
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.11708927
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.10970523
93JUN_21703547_ChIP-Seq_K562_Human1.10839952
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09114569
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09114569
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.07811960
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06620260
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05029304
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04224594
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04209915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.99449437
2MP0003136_yellow_coat_color3.36130981
3MP0001486_abnormal_startle_reflex3.12319946
4MP0001984_abnormal_olfaction2.92507635
5MP0004859_abnormal_synaptic_plasticity2.88269173
6MP0002736_abnormal_nociception_after2.74057560
7MP0005377_hearing/vestibular/ear_phenot2.67579653
8MP0003878_abnormal_ear_physiology2.67579653
9MP0001968_abnormal_touch/_nociception2.62244711
10MP0009046_muscle_twitch2.57920786
11MP0004742_abnormal_vestibular_system2.40410709
12MP0001485_abnormal_pinna_reflex2.36887739
13MP0003635_abnormal_synaptic_transmissio2.36701734
14MP0009745_abnormal_behavioral_response2.32182541
15MP0002272_abnormal_nervous_system2.28979333
16MP0003011_delayed_dark_adaptation2.25767953
17MP0002064_seizures2.23080956
18MP0002653_abnormal_ependyma_morphology2.18293967
19MP0004270_analgesia2.18262901
20MP0004147_increased_porphyrin_level2.14611388
21MP0005423_abnormal_somatic_nervous2.01895727
22MP0002067_abnormal_sensory_capabilities2.01472048
23MP0002063_abnormal_learning/memory/cond2.01070702
24MP0002572_abnormal_emotion/affect_behav1.98381332
25MP0000778_abnormal_nervous_system1.91905208
26MP0005551_abnormal_eye_electrophysiolog1.88953853
27MP0002638_abnormal_pupillary_reflex1.86027301
28MP0002734_abnormal_mechanical_nocicepti1.74871239
29MP0008877_abnormal_DNA_methylation1.74393558
30MP0003137_abnormal_impulse_conducting1.71371232
31MP0005171_absent_coat_pigmentation1.70934396
32MP0001501_abnormal_sleep_pattern1.65012877
33MP0001529_abnormal_vocalization1.60789569
34MP0004043_abnormal_pH_regulation1.59757812
35MP0004215_abnormal_myocardial_fiber1.56074690
36MP0002735_abnormal_chemical_nociception1.52400768
37MP0001970_abnormal_pain_threshold1.47022238
38MP0002557_abnormal_social/conspecific_i1.45038492
39MP0004484_altered_response_of1.39679667
40MP0001986_abnormal_taste_sensitivity1.39249941
41MP0004885_abnormal_endolymph1.37412006
42MP0008569_lethality_at_weaning1.35227784
43MP0005253_abnormal_eye_physiology1.33984737
44MP0000026_abnormal_inner_ear1.33871424
45MP0001963_abnormal_hearing_physiology1.33354421
46MP0008789_abnormal_olfactory_epithelium1.31312655
47MP0006276_abnormal_autonomic_nervous1.28782932
48MP0005248_abnormal_Harderian_gland1.25650239
49MP0005499_abnormal_olfactory_system1.25002310
50MP0005394_taste/olfaction_phenotype1.25002310
51MP0002882_abnormal_neuron_morphology1.22322825
52MP0002229_neurodegeneration1.20777826
53MP0005646_abnormal_pituitary_gland1.19899838
54MP0000383_abnormal_hair_follicle1.19689393
55MP0000647_abnormal_sebaceous_gland1.18887371
56MP0000955_abnormal_spinal_cord1.17950893
57MP0002733_abnormal_thermal_nociception1.17791255
58MP0005187_abnormal_penis_morphology1.16157198
59MP0002095_abnormal_skin_pigmentation1.15351991
60MP0000569_abnormal_digit_pigmentation1.14951559
61MP0004142_abnormal_muscle_tone1.12599657
62MP0001440_abnormal_grooming_behavior1.12116874
63MP0000427_abnormal_hair_cycle1.09491991
64MP0008872_abnormal_physiological_respon1.09387150
65MP0002752_abnormal_somatic_nervous1.07577882
66MP0000631_abnormal_neuroendocrine_gland1.06857543
67MP0002152_abnormal_brain_morphology1.05452198
68MP0002066_abnormal_motor_capabilities/c1.02245696
69MP0004924_abnormal_behavior1.02042029
70MP0005386_behavior/neurological_phenoty1.02042029
71MP0000920_abnormal_myelination1.01505236
72MP0002249_abnormal_larynx_morphology1.00626600
73MP0002184_abnormal_innervation1.00204430
74MP0003633_abnormal_nervous_system0.97356951
75MP0004811_abnormal_neuron_physiology0.96287095
76MP0003868_abnormal_feces_composition0.92181058
77MP0005195_abnormal_posterior_eye0.92073571
78MP0002751_abnormal_autonomic_nervous0.88238871
79MP0005174_abnormal_tail_pigmentation0.86610365
80MP0006072_abnormal_retinal_apoptosis0.83924954
81MP0001177_atelectasis0.83397172
82MP0002233_abnormal_nose_morphology0.81059567
83MP0003631_nervous_system_phenotype0.79792897
84MP0009384_cardiac_valve_regurgitation0.78865141
85MP0003787_abnormal_imprinting0.78853768
86MP0003755_abnormal_palate_morphology0.77943461
87MP0002282_abnormal_trachea_morphology0.77632120
88MP0003634_abnormal_glial_cell0.77364292
89MP0003195_calcinosis0.76589851
90MP0003698_abnormal_male_reproductive0.75245878
91MP0000579_abnormal_nail_morphology0.73354356
92MP0001919_abnormal_reproductive_system0.72629880
93MP0001502_abnormal_circadian_rhythm0.72529079
94MP0003632_abnormal_nervous_system0.72471977
95MP0001764_abnormal_homeostasis0.72420499
96MP0002160_abnormal_reproductive_system0.70997928
97MP0003861_abnormal_nervous_system0.70515480
98MP0005084_abnormal_gallbladder_morpholo0.70380898
99MP0000049_abnormal_middle_ear0.69667133
100MP0004085_abnormal_heartbeat0.68309720

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.64586238
2Hyperventilation (HP:0002883)4.29847034
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.28608375
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.28608375
5Action tremor (HP:0002345)4.22159180
6Hemiparesis (HP:0001269)4.15948634
7Atonic seizures (HP:0010819)3.87066437
8Abnormality of the corticospinal tract (HP:0002492)3.69975560
9Gait imbalance (HP:0002141)3.57333841
10Congenital primary aphakia (HP:0007707)3.40888106
11Medial flaring of the eyebrow (HP:0010747)3.36526453
12Broad-based gait (HP:0002136)3.34891357
13Febrile seizures (HP:0002373)3.29451986
14True hermaphroditism (HP:0010459)3.20299586
15Hemiplegia (HP:0002301)3.09419893
16Nephrogenic diabetes insipidus (HP:0009806)2.97107458
17Progressive inability to walk (HP:0002505)2.90220053
18Genital tract atresia (HP:0001827)2.87536091
19Ventricular fibrillation (HP:0001663)2.86757772
20Pancreatic fibrosis (HP:0100732)2.86687559
21Myokymia (HP:0002411)2.83370699
22Focal seizures (HP:0007359)2.79847578
23Vaginal atresia (HP:0000148)2.78914054
24Split foot (HP:0001839)2.68676259
25Termporal pattern (HP:0011008)2.68146187
26Insidious onset (HP:0003587)2.68146187
27Dysdiadochokinesis (HP:0002075)2.68108747
28Retinal dysplasia (HP:0007973)2.66923227
29Colon cancer (HP:0003003)2.63922120
30Progressive cerebellar ataxia (HP:0002073)2.60343525
31Spastic gait (HP:0002064)2.58747735
32Oligodactyly (hands) (HP:0001180)2.58541328
33Pancreatic cysts (HP:0001737)2.57127883
34Morphological abnormality of the pyramidal tract (HP:0002062)2.56689623
35Impaired vibration sensation in the lower limbs (HP:0002166)2.55916511
36Inability to walk (HP:0002540)2.53282975
37Generalized tonic-clonic seizures (HP:0002069)2.51473087
38Absent speech (HP:0001344)2.51095858
39Epileptic encephalopathy (HP:0200134)2.46472140
40Abnormality of midbrain morphology (HP:0002418)2.45517830
41Molar tooth sign on MRI (HP:0002419)2.45517830
42Urinary bladder sphincter dysfunction (HP:0002839)2.44080388
43Absence seizures (HP:0002121)2.42899739
44Drooling (HP:0002307)2.41873166
45Hyperglycinemia (HP:0002154)2.39908238
46Type II lissencephaly (HP:0007260)2.39280053
47Dialeptic seizures (HP:0011146)2.34465265
48Poor coordination (HP:0002370)2.32963657
49Syncope (HP:0001279)2.29427744
50Long nose (HP:0003189)2.28320958
51Urinary urgency (HP:0000012)2.28221405
52Abnormality of serine family amino acid metabolism (HP:0010894)2.22167904
53Abnormality of glycine metabolism (HP:0010895)2.22167904
54Polyphagia (HP:0002591)2.22038780
55Spastic tetraparesis (HP:0001285)2.20536248
56Lower limb muscle weakness (HP:0007340)2.18136204
57Excessive salivation (HP:0003781)2.18052301
58Prolonged QT interval (HP:0001657)2.17254885
59Hyperglycinuria (HP:0003108)2.15524768
60Truncal ataxia (HP:0002078)2.10450123
61Specific learning disability (HP:0001328)2.10349581
62Abolished electroretinogram (ERG) (HP:0000550)2.07963276
63Gaze-evoked nystagmus (HP:0000640)2.06492604
64Nephronophthisis (HP:0000090)2.04732700
65Broad foot (HP:0001769)2.04031692
66Optic nerve hypoplasia (HP:0000609)2.00390385
67Congenital sensorineural hearing impairment (HP:0008527)1.99841472
68Ankle clonus (HP:0011448)1.98275577
69Sclerocornea (HP:0000647)1.97830365
70Neoplasm of the oral cavity (HP:0100649)1.92906465
71Abnormality of the renal medulla (HP:0100957)1.92790667
72Postaxial hand polydactyly (HP:0001162)1.92685368
73Ulnar claw (HP:0001178)1.92148162
74Pachygyria (HP:0001302)1.91127367
75Postural tremor (HP:0002174)1.90990632
76Cerebellar dysplasia (HP:0007033)1.90185463
77Glioma (HP:0009733)1.90025370
78Anencephaly (HP:0002323)1.88857161
79Abnormality of binocular vision (HP:0011514)1.88736265
80Diplopia (HP:0000651)1.88736265
81Aplasia/Hypoplasia of the lens (HP:0008063)1.88727825
82Abnormality of the labia minora (HP:0012880)1.87573538
83Lissencephaly (HP:0001339)1.87321483
84Intestinal atresia (HP:0011100)1.85620684
85Decreased central vision (HP:0007663)1.85475989
86Oligodactyly (HP:0012165)1.84465793
87Cystic liver disease (HP:0006706)1.83976716
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.83377719
89Bronchomalacia (HP:0002780)1.81733352
90Sensorimotor neuropathy (HP:0007141)1.81261084
91Postaxial foot polydactyly (HP:0001830)1.80854520
92Congenital hepatic fibrosis (HP:0002612)1.79943605
93Epileptiform EEG discharges (HP:0011182)1.77627887
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73957542
95Gastrointestinal atresia (HP:0002589)1.73895581
96Epidermoid cyst (HP:0200040)1.71173702
97Large for gestational age (HP:0001520)1.69548044
98Spastic paraplegia (HP:0001258)1.68579694
99Spastic tetraplegia (HP:0002510)1.68311831
100Left ventricular hypertrophy (HP:0001712)1.68031171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.95134400
2PNCK4.60517381
3WEE13.16438951
4BMPR1B2.75595590
5PINK12.67916224
6MARK12.52644540
7NTRK22.52147061
8TNIK2.38239056
9CCNB12.26495822
10MAP3K42.20463415
11NTRK32.11806672
12EPHA42.07727073
13MAP2K71.82669062
14MAPK131.80312221
15BCR1.75934989
16PDK21.72349369
17MAPK151.72258191
18PBK1.70679657
19FRK1.65450253
20TSSK61.62551257
21WNK31.58339716
22CSNK1A1L1.50732015
23NEK91.45015392
24CSNK1G11.44984446
25PAK61.42775677
26CSNK1G21.42644849
27CSNK1G31.40908681
28INSRR1.38770806
29ERBB41.29828489
30BRSK21.20679697
31STK391.18869488
32PRKCG1.16824885
33PLK21.15475589
34ERBB31.07496996
35RPS6KA41.07303866
36WNK41.00741708
37PKN10.99973149
38GRK10.99284448
39AKT30.95619938
40CAMK2A0.94986820
41UHMK10.94492151
42TAOK30.93527678
43TYRO30.92847336
44ADRBK20.91956668
45SGK20.87274581
46PRKCE0.85867179
47CAMKK20.79918415
48CDK30.79137572
49CAMK2B0.77599110
50FGFR20.70564424
51CAMK2G0.69644637
52SGK2230.68955851
53SGK4940.68955851
54CAMK2D0.68470748
55DYRK30.67106428
56OXSR10.67094257
57STK38L0.64456602
58MINK10.64212051
59MKNK20.63463767
60ACVR1B0.62507106
61DAPK20.60731106
62BCKDK0.60130200
63MAP4K20.59209262
64NUAK10.58551918
65ADRBK10.58525234
66DYRK20.58438452
67CDK80.57141117
68CDK50.56541810
69NEK10.54391807
70GRK50.53131503
71ROCK20.53065212
72MAP2K40.52969360
73BRD40.51177546
74PHKG20.50773727
75PHKG10.50773727
76TRIM280.49286925
77PRKG10.48707437
78IRAK20.48446127
79ZAK0.48126602
80PRKD30.48095779
81BRSK10.47153710
82IRAK10.46292183
83SGK10.45534249
84MAPK70.42993372
85TIE10.42978130
86TGFBR10.41524713
87ROCK10.41077666
88VRK10.40121161
89CSNK1A10.39903253
90PAK30.39307610
91EPHA30.39179282
92MAP3K60.38825948
93NEK60.38333005
94RPS6KA50.38084067
95MOS0.37120434
96EPHB10.36486331
97PRKACA0.35533171
98PLK10.35115422
99CAMK40.32928629
100DYRK1A0.32912879

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60915883
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74047298
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52412177
4GABAergic synapse_Homo sapiens_hsa047272.51215790
5Glutamatergic synapse_Homo sapiens_hsa047242.41168494
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37351219
7Nitrogen metabolism_Homo sapiens_hsa009102.36819522
8Butanoate metabolism_Homo sapiens_hsa006502.34592698
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30866199
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25507758
11Circadian entrainment_Homo sapiens_hsa047132.23723072
12Morphine addiction_Homo sapiens_hsa050322.11952541
13Steroid biosynthesis_Homo sapiens_hsa001002.07036841
14Propanoate metabolism_Homo sapiens_hsa006402.04968419
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76403355
16Dopaminergic synapse_Homo sapiens_hsa047281.71922930
17Amphetamine addiction_Homo sapiens_hsa050311.63960342
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63913527
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62929542
20Fatty acid elongation_Homo sapiens_hsa000621.61790052
21Phototransduction_Homo sapiens_hsa047441.60091450
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58350111
23Cocaine addiction_Homo sapiens_hsa050301.53941508
24Taste transduction_Homo sapiens_hsa047421.52296243
25Dorso-ventral axis formation_Homo sapiens_hsa043201.46239692
26Gastric acid secretion_Homo sapiens_hsa049711.43805802
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39808448
28Insulin secretion_Homo sapiens_hsa049111.39720144
29Fatty acid metabolism_Homo sapiens_hsa012121.39165452
30beta-Alanine metabolism_Homo sapiens_hsa004101.35080305
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33981700
32Calcium signaling pathway_Homo sapiens_hsa040201.28445746
33Long-term depression_Homo sapiens_hsa047301.28105336
34Salivary secretion_Homo sapiens_hsa049701.27641011
35Protein export_Homo sapiens_hsa030601.22725680
36Sulfur relay system_Homo sapiens_hsa041221.19158978
37Peroxisome_Homo sapiens_hsa041461.16363334
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14582293
39Cholinergic synapse_Homo sapiens_hsa047251.09438802
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03794335
41Serotonergic synapse_Homo sapiens_hsa047261.02869621
42cAMP signaling pathway_Homo sapiens_hsa040241.01138225
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99818881
44ABC transporters_Homo sapiens_hsa020100.98683037
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97669817
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97286130
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97037704
48Regulation of autophagy_Homo sapiens_hsa041400.93674948
49Oocyte meiosis_Homo sapiens_hsa041140.92834591
50Olfactory transduction_Homo sapiens_hsa047400.92059246
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92052612
52Fanconi anemia pathway_Homo sapiens_hsa034600.90988656
53PPAR signaling pathway_Homo sapiens_hsa033200.90425670
54Circadian rhythm_Homo sapiens_hsa047100.90396197
55Renin secretion_Homo sapiens_hsa049240.89862422
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85876271
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83893675
58Long-term potentiation_Homo sapiens_hsa047200.81948634
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.80675030
60Ether lipid metabolism_Homo sapiens_hsa005650.79729518
61Oxidative phosphorylation_Homo sapiens_hsa001900.79158166
62Parkinsons disease_Homo sapiens_hsa050120.78968645
63Histidine metabolism_Homo sapiens_hsa003400.77586909
64Synaptic vesicle cycle_Homo sapiens_hsa047210.75485217
65Estrogen signaling pathway_Homo sapiens_hsa049150.74584276
66Fatty acid biosynthesis_Homo sapiens_hsa000610.74008473
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73731448
68Collecting duct acid secretion_Homo sapiens_hsa049660.71115144
69Tryptophan metabolism_Homo sapiens_hsa003800.70583725
70Folate biosynthesis_Homo sapiens_hsa007900.69606961
71Linoleic acid metabolism_Homo sapiens_hsa005910.69421575
72Thyroid hormone synthesis_Homo sapiens_hsa049180.68403050
73Gap junction_Homo sapiens_hsa045400.66164026
74Axon guidance_Homo sapiens_hsa043600.65547007
75Alzheimers disease_Homo sapiens_hsa050100.60381424
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59856517
77Fatty acid degradation_Homo sapiens_hsa000710.57628468
78Pancreatic secretion_Homo sapiens_hsa049720.56524235
79Oxytocin signaling pathway_Homo sapiens_hsa049210.55416489
80Cardiac muscle contraction_Homo sapiens_hsa042600.55261974
81Hippo signaling pathway_Homo sapiens_hsa043900.55111428
82Basal transcription factors_Homo sapiens_hsa030220.54673011
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54093098
84Huntingtons disease_Homo sapiens_hsa050160.52856726
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50091804
86Bile secretion_Homo sapiens_hsa049760.49026551
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45439019
88Basal cell carcinoma_Homo sapiens_hsa052170.45081830
89Prion diseases_Homo sapiens_hsa050200.41838034
90Melanogenesis_Homo sapiens_hsa049160.40529549
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39965802
92Glycerolipid metabolism_Homo sapiens_hsa005610.37468065
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36873799
94Arginine and proline metabolism_Homo sapiens_hsa003300.36841715
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.32463740
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31627997
97Pyruvate metabolism_Homo sapiens_hsa006200.31441422
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30821808
99Choline metabolism in cancer_Homo sapiens_hsa052310.29972139
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28445242

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