ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.88807733
2	axon ensheathment in central nervous system (GO:0032291)	6.74543677
3	central nervous system myelination (GO:0022010)	6.74543677
4	ATP synthesis coupled proton transport (GO:0015986)	6.53443705
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.53443705
6	ribosomal small subunit biogenesis (GO:0042274)	6.30078673
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.15305729
8	cotranslational protein targeting to membrane (GO:0006613)	5.95999204
9	viral transcription (GO:0019083)	5.91414116
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.89270275
11	protein targeting to ER (GO:0045047)	5.88020368
12	ribosomal small subunit assembly (GO:0000028)	5.65967200
13	translational termination (GO:0006415)	5.63315169
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.62851430
15	protein localization to endoplasmic reticulum (GO:0070972)	5.62570502
16	respiratory electron transport chain (GO:0022904)	5.37022666
17	electron transport chain (GO:0022900)	5.22743967
18	protein neddylation (GO:0045116)	4.97541116
19	signal peptide processing (GO:0006465)	4.73060488
20	translational elongation (GO:0006414)	4.59491455
21	fatty acid elongation (GO:0030497)	4.47940650
22	viral life cycle (GO:0019058)	4.46667446
23	regulation of mitochondrial translation (GO:0070129)	4.40764608
24	cellular protein complex disassembly (GO:0043624)	4.38003316
25	proteasome assembly (GO:0043248)	4.33463908
26	chaperone-mediated protein transport (GO:0072321)	4.32053637
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.29466544
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.29466544
29	NADH dehydrogenase complex assembly (GO:0010257)	4.29466544
30	GPI anchor biosynthetic process (GO:0006506)	4.19721714
31	protein complex biogenesis (GO:0070271)	4.19657037
32	translation (GO:0006412)	4.06336930
33	maturation of SSU-rRNA (GO:0030490)	4.02995362
34	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.99902084
35	inner mitochondrial membrane organization (GO:0007007)	3.94922694
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.94433585
37	termination of RNA polymerase III transcription (GO:0006386)	3.94433585
38	translational initiation (GO:0006413)	3.91329950
39	protein targeting to membrane (GO:0006612)	3.90327559
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.75411764
41	rRNA modification (GO:0000154)	3.73895781
42	mRNA catabolic process (GO:0006402)	3.73647355
43	sequestering of actin monomers (GO:0042989)	3.69432901
44	ribosomal large subunit biogenesis (GO:0042273)	3.67816527
45	mannosylation (GO:0097502)	3.67404086
46	GPI anchor metabolic process (GO:0006505)	3.65333090
47	chromatin remodeling at centromere (GO:0031055)	3.62744646
48	protein complex disassembly (GO:0043241)	3.60182499
49	respiratory chain complex IV assembly (GO:0008535)	3.59582528
50	GTP biosynthetic process (GO:0006183)	3.59170927
51	CENP-A containing nucleosome assembly (GO:0034080)	3.58808469
52	spliceosomal snRNP assembly (GO:0000387)	3.57563477
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.54846253
54	DNA deamination (GO:0045006)	3.52632684
55	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.43319383
56	protein localization to mitochondrion (GO:0070585)	3.42946523
57	RNA catabolic process (GO:0006401)	3.41982836
58	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.41709715
59	preassembly of GPI anchor in ER membrane (GO:0016254)	3.41223343
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.40903518
61	macromolecular complex disassembly (GO:0032984)	3.39839721
62	establishment of integrated proviral latency (GO:0075713)	3.38231814
63	intracellular protein transmembrane import (GO:0044743)	3.35727233
64	oxidative phosphorylation (GO:0006119)	3.35015395
65	ribonucleoprotein complex biogenesis (GO:0022613)	3.34021320
66	long-chain fatty acid biosynthetic process (GO:0042759)	3.33637314
67	nucleotide transmembrane transport (GO:1901679)	3.30112804
68	establishment of viral latency (GO:0019043)	3.24286023
69	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.22967666
70	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.22329871
71	spliceosomal complex assembly (GO:0000245)	3.20760140
72	protein targeting to mitochondrion (GO:0006626)	3.20685609
73	nucleoside triphosphate biosynthetic process (GO:0009142)	3.20602701
74	pseudouridine synthesis (GO:0001522)	3.19699883
75	protein-cofactor linkage (GO:0018065)	3.18923208
76	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18200618
77	ensheathment of neurons (GO:0007272)	3.17955600
78	axon ensheathment (GO:0008366)	3.17955600
79	myelination (GO:0042552)	3.17442882
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16633894
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16633894
82	mitochondrial transport (GO:0006839)	3.15433142
83	cholesterol biosynthetic process (GO:0006695)	3.15284703
84	hydrogen ion transmembrane transport (GO:1902600)	3.13898976
85	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13092056
86	rRNA processing (GO:0006364)	3.12394999
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11971886
88	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.09941270
89	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.09941270
90	establishment of protein localization to mitochondrion (GO:0072655)	3.06849705
91	ATP biosynthetic process (GO:0006754)	3.06494816
92	water-soluble vitamin biosynthetic process (GO:0042364)	3.06393413
93	7-methylguanosine mRNA capping (GO:0006370)	3.06022664
94	RNA capping (GO:0036260)	3.05996379
95	7-methylguanosine RNA capping (GO:0009452)	3.05996379
96	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.03940240
97	DNA damage response, detection of DNA damage (GO:0042769)	3.03449124
98	peptidyl-histidine modification (GO:0018202)	3.03379677
99	UTP biosynthetic process (GO:0006228)	3.03115810
100	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01400039
101	rRNA metabolic process (GO:0016072)	3.00923181
102	C-terminal protein lipidation (GO:0006501)	2.99010968
103	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.97356342
104	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.97356342
105	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.96211310
106	cytochrome complex assembly (GO:0017004)	2.95707299
107	GDP-mannose metabolic process (GO:0019673)	2.94403539
108	regulation of cellular amino acid metabolic process (GO:0006521)	2.92187563
109	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91615301
110	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90468945
111	negative regulation of ligase activity (GO:0051352)	2.90468945
112	cellular component biogenesis (GO:0044085)	2.88759552
113	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.88333695
114	proton transport (GO:0015992)	2.88041604
115	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.87753442
116	protein targeting (GO:0006605)	2.87739824
117	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.86492532
118	isoprenoid biosynthetic process (GO:0008299)	2.85652447
119	establishment of protein localization to membrane (GO:0090150)	2.85464027
120	neutrophil activation involved in immune response (GO:0002283)	2.84941376
121	substantia nigra development (GO:0021762)	2.84287065
122	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.82002549
123	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.82002549
124	guanosine-containing compound biosynthetic process (GO:1901070)	2.81573431
125	CTP biosynthetic process (GO:0006241)	2.79842065
126	CTP metabolic process (GO:0046036)	2.79842065
127	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.78476057
128	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.78476057
129	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.78476057
130	hydrogen transport (GO:0006818)	2.77880519
131	amyloid precursor protein metabolic process (GO:0042982)	2.76262404
132	sterol biosynthetic process (GO:0016126)	2.75288438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.55255411
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.91360670
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.81815069
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.22293380
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.99657745
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.87968063
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.83949954
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.70411619
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.44959857
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.39190751
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.33425438
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.25364335
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.25275828
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.01243847
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.95927809
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.81192483
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.75488899
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.50196787
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.48150363
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.45546053
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.34828835
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.30459021
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.14242737
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13212138
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.12740838
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.08612014
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.00992940
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98632919
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.95666448
30	XRN2_22483619_ChIP-Seq_HELA_Human	1.88823107
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.83226894
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82707379
33	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.76500993
34	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.71468552
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.68554375
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68345839
37	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.67402149
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.66898747
39	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.62666399
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.60376683
41	E2F7_22180533_ChIP-Seq_HELA_Human	1.56838578
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56169628
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.53642442
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.53609820
45	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.50263422
46	EWS_26573619_Chip-Seq_HEK293_Human	1.49274756
47	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48530165
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.48482124
49	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.44802461
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.32927643
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31822153
52	ZNF274_21170338_ChIP-Seq_K562_Hela	1.31416749
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.26298391
54	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.24944498
55	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.24677795
56	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.22552189
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19486279
58	STAT1_20625510_ChIP-Seq_HELA_Human	1.19242571
59	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.14788527
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.10702308
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.10508060
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.08670937
63	VDR_22108803_ChIP-Seq_LS180_Human	1.08615508
64	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07345425
65	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01526213
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99832509
67	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97575526
68	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97480829
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96378625
70	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95982924
71	TP53_22573176_ChIP-Seq_HFKS_Human	0.94620840
72	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.94070522
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92331791
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91814789
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.90853586
76	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.89976972
77	SPI1_23547873_ChIP-Seq_NB4_Human	0.89303812
78	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88823352
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.87845220
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87829409
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.87072909
82	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.86804855
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86730651
84	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.86532961
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.84791060
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.84106115
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83807632
88	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83227520
89	P300_19829295_ChIP-Seq_ESCs_Human	0.80998266
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.80757025
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.80697640
92	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.80547969
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.79954033
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.78698568
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.78698568
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.78584830
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.78004189
98	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.77379052
99	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.77259439
100	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.76906656
101	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.76656715
102	HTT_18923047_ChIP-ChIP_STHdh_Human	0.76418177
103	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.76203353
104	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.76090078
105	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75742641
106	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.75613401
107	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.75525588
108	AR_20517297_ChIP-Seq_VCAP_Human	0.75388004
109	ELF5_23300383_ChIP-Seq_T47D_Human	0.74617318
110	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.74388708
111	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.73130499
112	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.72846069
113	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.71893103
114	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.71542749
115	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.71045964
116	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.69338028
117	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.68963277
118	FUS_26573619_Chip-Seq_HEK293_Human	0.68187605
119	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.67918798
120	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.67309214
121	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.67205569
122	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.66737327
123	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.66159445
124	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.66067085
125	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.65923637
126	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.65668018
127	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.65553229
128	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.65134117
129	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.64604160
130	ER_23166858_ChIP-Seq_MCF-7_Human	0.63453155
131	CTCF_20526341_ChIP-Seq_ESCs_Human	0.62264757
132	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.61744593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.33253393
2	MP0000920_abnormal_myelination	3.79022471
3	MP0003136_yellow_coat_color	3.37986418
4	MP0001529_abnormal_vocalization	3.31223543
5	MP0001905_abnormal_dopamine_level	2.72972480
6	MP0010030_abnormal_orbit_morphology	2.72834454
7	MP0003806_abnormal_nucleotide_metabolis	2.61361741
8	MP0004381_abnormal_hair_follicle	2.43880920
9	MP0003950_abnormal_plasma_membrane	2.41733739
10	MP0005409_darkened_coat_color	2.37153751
11	MP0003186_abnormal_redox_activity	2.15934754
12	MP0005379_endocrine/exocrine_gland_phen	2.15728884
13	MP0005171_absent_coat_pigmentation	2.12175580
14	MP0004147_increased_porphyrin_level	1.98541620
15	MP0001986_abnormal_taste_sensitivity	1.98480683
16	MP0008995_early_reproductive_senescence	1.97504748
17	MP0002148_abnormal_hypersensitivity_rea	1.94667514
18	MP0002938_white_spotting	1.92950914
19	MP0004142_abnormal_muscle_tone	1.91445045
20	MP0004043_abnormal_pH_regulation	1.89063805
21	MP0005408_hypopigmentation	1.88359856
22	MP0001293_anophthalmia	1.87050292
23	MP0003724_increased_susceptibility_to	1.86388278
24	MP0005451_abnormal_body_composition	1.81227000
25	MP0001485_abnormal_pinna_reflex	1.80297186
26	MP0005075_abnormal_melanosome_morpholog	1.78994550
27	MP0005410_abnormal_fertilization	1.78709838
28	MP0002163_abnormal_gland_morphology	1.78459741
29	MP0008789_abnormal_olfactory_epithelium	1.76130967
30	MP0006036_abnormal_mitochondrial_physio	1.74082796
31	MP0000372_irregular_coat_pigmentation	1.66081767
32	MP0002638_abnormal_pupillary_reflex	1.60751293
33	MP0004742_abnormal_vestibular_system	1.59410647
34	MP0003880_abnormal_central_pattern	1.57615851
35	MP0010094_abnormal_chromosome_stability	1.56815575
36	MP0003941_abnormal_skin_development	1.55322364
37	MP0002653_abnormal_ependyma_morphology	1.51612856
38	MP0000462_abnormal_digestive_system	1.49267963
39	MP0002736_abnormal_nociception_after	1.44979411
40	MP0009697_abnormal_copulation	1.43010599
41	MP0008877_abnormal_DNA_methylation	1.42770111
42	MP0008057_abnormal_DNA_replication	1.42602968
43	MP0006072_abnormal_retinal_apoptosis	1.40154059
44	MP0009785_altered_susceptibility_to	1.37385167
45	MP0002102_abnormal_ear_morphology	1.36619863
46	MP0001984_abnormal_olfaction	1.34327911
47	MP0009333_abnormal_splenocyte_physiolog	1.33972700
48	MP0001727_abnormal_embryo_implantation	1.30126871
49	MP0006082_CNS_inflammation	1.29391482
50	MP0003077_abnormal_cell_cycle	1.29381606
51	MP0008932_abnormal_embryonic_tissue	1.29204093
52	MP0010386_abnormal_urinary_bladder	1.25016086
53	MP0006292_abnormal_olfactory_placode	1.24017171
54	MP0005000_abnormal_immune_tolerance	1.21690815
55	MP0000049_abnormal_middle_ear	1.21678219
56	MP0004133_heterotaxia	1.21249137
57	MP0003315_abnormal_perineum_morphology	1.20108527
58	MP0003634_abnormal_glial_cell	1.19933850
59	MP0005671_abnormal_response_to	1.19342014
60	MP0003718_maternal_effect	1.18541813
61	MP0008260_abnormal_autophagy	1.17930507
62	MP0005025_abnormal_response_to	1.15623129
63	MP0000613_abnormal_salivary_gland	1.15421579
64	MP0003111_abnormal_nucleus_morphology	1.14957322
65	MP0005394_taste/olfaction_phenotype	1.11962672
66	MP0005499_abnormal_olfactory_system	1.11962672
67	MP0002277_abnormal_respiratory_mucosa	1.11055796
68	MP0000566_synostosis	1.10439528
69	MP0002210_abnormal_sex_determination	1.10145640
70	MP0005174_abnormal_tail_pigmentation	1.08994122
71	MP0001968_abnormal_touch/_nociception	1.06511091
72	MP0003283_abnormal_digestive_organ	1.06041159
73	MP0004134_abnormal_chest_morphology	1.05350770
74	MP0003195_calcinosis	1.03759946
75	MP0001346_abnormal_lacrimal_gland	1.03101215
76	MP0002272_abnormal_nervous_system	1.02278810
77	MP0002933_joint_inflammation	1.01674466
78	MP0008058_abnormal_DNA_repair	1.01264364
79	MP0006054_spinal_hemorrhage	1.00904699
80	MP0001835_abnormal_antigen_presentation	1.00510236
81	MP0002233_abnormal_nose_morphology	1.00259973
82	MP0002751_abnormal_autonomic_nervous	0.99227233
83	MP0002229_neurodegeneration	0.98897367
84	MP0003567_abnormal_fetal_cardiomyocyte	0.98693462
85	MP0002160_abnormal_reproductive_system	0.98525089
86	MP0001286_abnormal_eye_development	0.98394017
87	MP0002132_abnormal_respiratory_system	0.98087337
88	MP0003121_genomic_imprinting	0.97213329
89	MP0008875_abnormal_xenobiotic_pharmacok	0.96778999
90	MP0003937_abnormal_limbs/digits/tail_de	0.95790108
91	MP0008872_abnormal_physiological_respon	0.95013065
92	MP0001764_abnormal_homeostasis	0.94872238
93	MP0002282_abnormal_trachea_morphology	0.94734023
94	MP0003656_abnormal_erythrocyte_physiolo	0.91405741
95	MP0001542_abnormal_bone_strength	0.90734418
96	MP0005389_reproductive_system_phenotype	0.90702354
97	MP0004957_abnormal_blastocyst_morpholog	0.90609522
98	MP0006276_abnormal_autonomic_nervous	0.90515788
99	MP0002234_abnormal_pharynx_morphology	0.90471269
100	MP0002419_abnormal_innate_immunity	0.90383724
101	MP0000749_muscle_degeneration	0.89368819
102	MP0005253_abnormal_eye_physiology	0.88777017
103	MP0001188_hyperpigmentation	0.88327655
104	MP0005084_abnormal_gallbladder_morpholo	0.87836838
105	MP0000653_abnormal_sex_gland	0.87227327
106	MP0002697_abnormal_eye_size	0.86669069
107	MP0001145_abnormal_male_reproductive	0.86552612
108	MP0005058_abnormal_lysosome_morphology	0.85904166
109	MP0003786_premature_aging	0.85679672
110	MP0002693_abnormal_pancreas_physiology	0.85355319
111	MP0004019_abnormal_vitamin_homeostasis	0.85239963
112	MP0001929_abnormal_gametogenesis	0.83630300
113	MP0002837_dystrophic_cardiac_calcinosis	0.83012124
114	MP0005391_vision/eye_phenotype	0.82939792
115	MP0005423_abnormal_somatic_nervous	0.82346161
116	MP0005377_hearing/vestibular/ear_phenot	0.82052765
117	MP0003878_abnormal_ear_physiology	0.82052765
118	MP0008007_abnormal_cellular_replicative	0.81673024
119	MP0002723_abnormal_immune_serum	0.81586776
120	MP0005636_abnormal_mineral_homeostasis	0.81332887
121	MP0002295_abnormal_pulmonary_circulatio	0.81174925
122	MP0009046_muscle_twitch	0.81147722
123	MP0003123_paternal_imprinting	0.81017152
124	MP0000631_abnormal_neuroendocrine_gland	0.80765713
125	MP0005195_abnormal_posterior_eye	0.80733657
126	MP0000762_abnormal_tongue_morphology	0.80567301
127	MP0001963_abnormal_hearing_physiology	0.79494646
128	MP0006035_abnormal_mitochondrial_morpho	0.78249542
129	MP0002095_abnormal_skin_pigmentation	0.77933368
130	MP0001919_abnormal_reproductive_system	0.77445120
131	MP0003690_abnormal_glial_cell	0.76407297
132	MP0001661_extended_life_span	0.75030428
133	MP0000026_abnormal_inner_ear	0.74803887
134	MP0000465_gastrointestinal_hemorrhage	0.74778249
135	MP0003119_abnormal_digestive_system	0.74018019
136	MP0003890_abnormal_embryonic-extraembry	0.73952140
137	MP0005551_abnormal_eye_electrophysiolog	0.73524172
138	MP0000470_abnormal_stomach_morphology	0.73393190
139	MP0001851_eye_inflammation	0.72644584
140	MP0000015_abnormal_ear_pigmentation	0.71905062
141	MP0001348_abnormal_lacrimal_gland	0.71125595
142	MP0003011_delayed_dark_adaptation	0.71101782
143	MP0009745_abnormal_behavioral_response	0.71100797
144	MP0002752_abnormal_somatic_nervous	0.71085788
145	MP0005645_abnormal_hypothalamus_physiol	0.70355662
146	MP0003693_abnormal_embryo_hatching	0.68995902
147	MP0004145_abnormal_muscle_electrophysio	0.68182764
148	MP0002420_abnormal_adaptive_immunity	0.67884161
149	MP0005083_abnormal_biliary_tract	0.67669762
150	MP0003938_abnormal_ear_development	0.66988779
151	MP0005381_digestive/alimentary_phenotyp	0.66639718
152	MP0000681_abnormal_thyroid_gland	0.65990488

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.07024329
2	Mitochondrial inheritance (HP:0001427)	5.41085838
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.32467960
4	Increased hepatocellular lipid droplets (HP:0006565)	5.13011543
5	Abnormality of cells of the erythroid lineage (HP:0012130)	5.12970207
6	Renal Fanconi syndrome (HP:0001994)	4.95347227
7	Acute encephalopathy (HP:0006846)	4.91354617
8	Progressive macrocephaly (HP:0004481)	4.89326863
9	Abnormal number of erythroid precursors (HP:0012131)	4.84424028
10	Lipid accumulation in hepatocytes (HP:0006561)	4.60058755
11	Hepatocellular necrosis (HP:0001404)	4.46632660
12	Increased CSF lactate (HP:0002490)	4.46008262
13	3-Methylglutaconic aciduria (HP:0003535)	4.44006014
14	Parakeratosis (HP:0001036)	4.03592971
15	Hepatic necrosis (HP:0002605)	3.98723107
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.95366927
17	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.87645728
18	Exertional dyspnea (HP:0002875)	3.79883158
19	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.73822044
20	Reticulocytopenia (HP:0001896)	3.67562183
21	Increased intramyocellular lipid droplets (HP:0012240)	3.61307020
22	Leukodystrophy (HP:0002415)	3.61205730
23	Congenital, generalized hypertrichosis (HP:0004540)	3.53673499
24	Macrocytic anemia (HP:0001972)	3.40815865
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.24212687
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.24212687
27	Abnormality of glycolysis (HP:0004366)	3.21366648
28	Increased serum pyruvate (HP:0003542)	3.21366648
29	Abnormality of renal resorption (HP:0011038)	3.20185175
30	Respiratory failure (HP:0002878)	3.16826188
31	Exercise intolerance (HP:0003546)	3.14223115
32	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.10898997
33	Cerebral edema (HP:0002181)	3.10312754
34	Optic disc pallor (HP:0000543)	3.05812406
35	Type I transferrin isoform profile (HP:0003642)	3.03499876
36	Increased muscle lipid content (HP:0009058)	3.00671198
37	Cerebral hypomyelination (HP:0006808)	2.99982205
38	Increased serum lactate (HP:0002151)	2.91244479
39	Septo-optic dysplasia (HP:0100842)	2.89182859
40	Lactic acidosis (HP:0003128)	2.76675713
41	Pallor (HP:0000980)	2.74285489
42	Respiratory difficulties (HP:0002880)	2.73661274
43	Congenital ichthyosiform erythroderma (HP:0007431)	2.73430222
44	Pancreatic cysts (HP:0001737)	2.68010784
45	Pancreatic fibrosis (HP:0100732)	2.63095278
46	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.55692050
47	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.55692050
48	Oral leukoplakia (HP:0002745)	2.54027661
49	Abnormal protein glycosylation (HP:0012346)	2.48732095
50	Abnormal glycosylation (HP:0012345)	2.48732095
51	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48732095
52	Abnormal protein N-linked glycosylation (HP:0012347)	2.48732095
53	Colon cancer (HP:0003003)	2.46999033
54	True hermaphroditism (HP:0010459)	2.46885356
55	Abnormality of midbrain morphology (HP:0002418)	2.45561661
56	Molar tooth sign on MRI (HP:0002419)	2.45561661
57	Methylmalonic aciduria (HP:0012120)	2.41571569
58	Glycosuria (HP:0003076)	2.41164059
59	Abnormality of urine glucose concentration (HP:0011016)	2.41164059
60	Lethargy (HP:0001254)	2.37827214
61	Generalized aminoaciduria (HP:0002909)	2.18194115
62	Patchy hypopigmentation of hair (HP:0011365)	2.16112751
63	Hyperphosphaturia (HP:0003109)	2.15718428
64	Sensory axonal neuropathy (HP:0003390)	2.14733204
65	Abnormality of the labia minora (HP:0012880)	2.14484496
66	Hepatosplenomegaly (HP:0001433)	2.13147190
67	Neurofibrillary tangles (HP:0002185)	2.08831826
68	Nephronophthisis (HP:0000090)	2.08805676
69	Hypoplastic pelvis (HP:0008839)	2.06022977
70	Absent thumb (HP:0009777)	2.04855375
71	Sclerocornea (HP:0000647)	1.96645872
72	Microvesicular hepatic steatosis (HP:0001414)	1.96294903
73	Hyperglycinemia (HP:0002154)	1.94392493
74	Pancytopenia (HP:0001876)	1.93342150
75	Abnormal urine phosphate concentration (HP:0012599)	1.92101021
76	Abnormality of methionine metabolism (HP:0010901)	1.91353916
77	Abnormal hemoglobin (HP:0011902)	1.90812895
78	Vacuolated lymphocytes (HP:0001922)	1.90143815
79	CNS demyelination (HP:0007305)	1.89847233
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89149006
81	X-linked dominant inheritance (HP:0001423)	1.88998572
82	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.87257019
83	Meckel diverticulum (HP:0002245)	1.86782704
84	White forelock (HP:0002211)	1.86450999
85	Amniotic constriction ring (HP:0009775)	1.83594608
86	Abnormality of placental membranes (HP:0011409)	1.83594608
87	Asplenia (HP:0001746)	1.83481175
88	Myokymia (HP:0002411)	1.82196601
89	Renal tubular dysfunction (HP:0000124)	1.81930193
90	Pendular nystagmus (HP:0012043)	1.80861234
91	Partial duplication of thumb phalanx (HP:0009944)	1.79972531
92	Retinal dysplasia (HP:0007973)	1.79423319
93	Triphalangeal thumb (HP:0001199)	1.79385172
94	Abnormality of the ileum (HP:0001549)	1.79068354
95	Stenosis of the external auditory canal (HP:0000402)	1.78909038
96	Aplastic anemia (HP:0001915)	1.78723751
97	Prolonged neonatal jaundice (HP:0006579)	1.78639756
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77111694
99	Male pseudohermaphroditism (HP:0000037)	1.77059708
100	Peripheral hypomyelination (HP:0007182)	1.76974891
101	Abnormality of the anterior horn cell (HP:0006802)	1.76484038
102	Degeneration of anterior horn cells (HP:0002398)	1.76484038
103	Rib fusion (HP:0000902)	1.74944543
104	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74539880
105	Optic nerve hypoplasia (HP:0000609)	1.71137407
106	Megaloblastic anemia (HP:0001889)	1.70681081
107	Reduced antithrombin III activity (HP:0001976)	1.70274519
108	Maternal diabetes (HP:0009800)	1.69450692
109	Bilateral microphthalmos (HP:0007633)	1.68761403
110	Abnormality of the septum pellucidum (HP:0007375)	1.68200717
111	CNS hypomyelination (HP:0003429)	1.67981811
112	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67952487
113	Hypoplasia of the pons (HP:0012110)	1.67534469
114	Depressed nasal ridge (HP:0000457)	1.65452148
115	Progressive neurologic deterioration (HP:0002344)	1.65362992
116	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.65202794
117	Abnormality of serum amino acid levels (HP:0003112)	1.65044139
118	Abnormal respiratory epithelium morphology (HP:0012253)	1.63895098
119	Duplicated collecting system (HP:0000081)	1.63687732
120	Hypoplasia of the uterus (HP:0000013)	1.62651937
121	Blindness (HP:0000618)	1.61336321
122	Split foot (HP:0001839)	1.60444864
123	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.60154881
124	Hypothermia (HP:0002045)	1.59514960
125	Methylmalonic acidemia (HP:0002912)	1.58048168
126	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.57948052
127	Congenital sensorineural hearing impairment (HP:0008527)	1.55586176
128	Emotional lability (HP:0000712)	1.54886740
129	Abnormality of the axillary hair (HP:0100134)	1.54819912
130	Abnormality of secondary sexual hair (HP:0009888)	1.54819912
131	Abnormality of macrophages (HP:0004311)	1.54671566
132	Rough bone trabeculation (HP:0100670)	1.54526315
133	Adrenal hypoplasia (HP:0000835)	1.53152203
134	Spastic paraparesis (HP:0002313)	1.51859565
135	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.49240368
136	Abnormal ciliary motility (HP:0012262)	1.49120830
137	Absent septum pellucidum (HP:0001331)	1.48682334
138	Erythroderma (HP:0001019)	1.48366915
139	Medial flaring of the eyebrow (HP:0010747)	1.47469730
140	Partial duplication of the phalanx of hand (HP:0009999)	1.47423268
141	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.46719367

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.15614568
2	STK39	3.88783833
3	STK16	3.64883071
4	PBK	3.40976167
5	NME2	3.21222003
6	MST4	3.07159139
7	CDC7	2.67002036
8	OXSR1	2.40403215
9	BUB1	2.33247552
10	VRK1	2.22194584
11	TNIK	2.16157953
12	WNK4	2.08719474
13	NUAK1	2.01427104
14	TESK2	1.97346379
15	LIMK1	1.97094870
16	EIF2AK3	1.93087512
17	TAF1	1.92726263
18	MAPKAPK5	1.84813164
19	BCR	1.84638072
20	PIM2	1.82845627
21	CDK19	1.81150909
22	NME1	1.76619318
23	IRAK4	1.75804466
24	MUSK	1.75119149
25	MAPK15	1.72016002
26	PLK3	1.66390745
27	MAP3K12	1.65220776
28	BMPR1B	1.54272923
29	PKN1	1.54245125
30	EPHB1	1.54240560
31	TLK1	1.53622670
32	DYRK2	1.36563385
33	ARAF	1.34975356
34	MAP4K2	1.34814653
35	MET	1.34525833
36	UHMK1	1.33272075
37	CSNK1G3	1.32667207
38	IRAK2	1.24753644
39	PINK1	1.24590485
40	IRAK3	1.23169243
41	TTK	1.22852538
42	PASK	1.22762570
43	NEK1	1.17794853
44	GRK7	1.16169367
45	INSRR	1.14595128
46	WEE1	1.11635036
47	IRAK1	1.08920516
48	ADRBK2	1.07858560
49	PLK1	1.05830381
50	CAMK2B	1.02640110
51	RPS6KA5	1.00860186
52	EIF2AK1	1.00424773
53	MYLK	0.98078563
54	CSNK1A1L	0.97780408
55	AURKB	0.96787618
56	CLK1	0.96191612
57	NEK6	0.92634369
58	MAP2K7	0.90923574
59	CAMK2D	0.90829120
60	PLK4	0.89844012
61	MKNK1	0.89659504
62	SRPK1	0.84730269
63	KDR	0.84698304
64	CSNK1G1	0.83922449
65	EPHB2	0.83824704
66	PNCK	0.82066094
67	ABL2	0.81755291
68	TESK1	0.80934912
69	CDK8	0.79778388
70	CHEK2	0.79501389
71	BMPR2	0.79430123
72	BCKDK	0.77071070
73	DYRK3	0.75425381
74	NEK2	0.74991234
75	MKNK2	0.73319235
76	FGFR2	0.72931448
77	CASK	0.72626132
78	MAP3K4	0.72317549
79	YES1	0.71120458
80	FGR	0.68078596
81	PRKCG	0.66680775
82	BRAF	0.65775400
83	TEC	0.65603686
84	BLK	0.64984545
85	EIF2AK2	0.63816175
86	PDK2	0.62491628
87	IKBKB	0.62378342
88	CAMK2G	0.61924753
89	OBSCN	0.61505314
90	ROCK2	0.61162762
91	ATR	0.59154669
92	MAP2K2	0.57168003
93	CCNB1	0.56369899
94	TGFBR1	0.56271745
95	LRRK2	0.56004741
96	PIK3CG	0.55822735
97	LYN	0.55498668
98	TRIM28	0.55081574
99	PAK1	0.54560302
100	CSNK1G2	0.52282683
101	STK4	0.52227363
102	TRPM7	0.51607215
103	BTK	0.51239145
104	ILK	0.50923852
105	CSNK2A1	0.49850341
106	PRKCQ	0.48738986
107	ZAK	0.47363755
108	CSNK2A2	0.46040615
109	TXK	0.45966117
110	AURKA	0.45016218
111	ADRBK1	0.44855566
112	CDK3	0.44538692
113	KIT	0.44440047
114	STK38L	0.43509399
115	GRK1	0.43438512
116	RPS6KB2	0.43232638
117	LCK	0.42617442
118	PHKG2	0.42502889
119	PHKG1	0.42502889
120	BRSK2	0.42489672
121	PRPF4B	0.40497759
122	CSNK1A1	0.40494109
123	PRKCE	0.40463569
124	WNK3	0.39701605
125	PLK2	0.38635950
126	CSNK1E	0.38149279
127	WNK1	0.37792213
128	BRSK1	0.37436899
129	MAP3K14	0.37007019
130	DAPK3	0.36072645
131	CAMK2A	0.36036859
132	FRK	0.35607013
133	GRK5	0.34406716
134	TAOK3	0.34191321
135	PRKCD	0.33770585
136	CDK7	0.33665563
137	STK24	0.33220052
138	EPHA4	0.32880253
139	TIE1	0.32292119
140	ATM	0.31826702
141	PRKACA	0.31766195
142	HIPK2	0.31556516
143	SYK	0.30050530
144	MAPK13	0.29559626
145	STK3	0.29328766

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.93000269
2	Protein export_Homo sapiens_hsa03060	4.82091827
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.69288196
4	Parkinsons disease_Homo sapiens_hsa05012	3.92397922
5	Proteasome_Homo sapiens_hsa03050	3.41716582
6	RNA polymerase_Homo sapiens_hsa03020	3.04802085
7	Alzheimers disease_Homo sapiens_hsa05010	2.99412990
8	Huntingtons disease_Homo sapiens_hsa05016	2.80747248
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.66013057
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.60246760
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39236878
12	Fatty acid elongation_Homo sapiens_hsa00062	2.30970003
13	Steroid biosynthesis_Homo sapiens_hsa00100	2.01783653
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71333068
15	DNA replication_Homo sapiens_hsa03030	1.66837072
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55696429
17	Sulfur metabolism_Homo sapiens_hsa00920	1.51163224
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51054311
19	Spliceosome_Homo sapiens_hsa03040	1.46863535
20	Homologous recombination_Homo sapiens_hsa03440	1.46241074
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.45572207
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.44802733
23	Mismatch repair_Homo sapiens_hsa03430	1.43538894
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.42578099
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37078233
26	Folate biosynthesis_Homo sapiens_hsa00790	1.32054975
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28405571
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.27865180
29	Basal transcription factors_Homo sapiens_hsa03022	1.24155825
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20319351
31	Glutathione metabolism_Homo sapiens_hsa00480	1.14192595
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.13888130
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11515082
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09765805
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06513408
36	Purine metabolism_Homo sapiens_hsa00230	1.04960279
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.03645973
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03232374
39	Vibrio cholerae infection_Homo sapiens_hsa05110	0.98828678
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93403337
41	Propanoate metabolism_Homo sapiens_hsa00640	0.91750846
42	Base excision repair_Homo sapiens_hsa03410	0.89314697
43	Metabolic pathways_Homo sapiens_hsa01100	0.81691394
44	RNA degradation_Homo sapiens_hsa03018	0.79375567
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.77944638
46	Histidine metabolism_Homo sapiens_hsa00340	0.77665343
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75636890
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.74755853
49	Asthma_Homo sapiens_hsa05310	0.74359921
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72086204
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69985241
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68552580
53	Other glycan degradation_Homo sapiens_hsa00511	0.68077964
54	Allograft rejection_Homo sapiens_hsa05330	0.67780909
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66577532
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66233487
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59549959
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59278891
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.55920099
60	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.55676147
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.55293303
62	Cell cycle_Homo sapiens_hsa04110	0.53514655
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53376900
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52841519
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.51357525
66	RNA transport_Homo sapiens_hsa03013	0.51139671
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50129217
68	Sulfur relay system_Homo sapiens_hsa04122	0.49705174
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.49232383
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.48505239
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48243651
72	Phagosome_Homo sapiens_hsa04145	0.47842011
73	Regulation of autophagy_Homo sapiens_hsa04140	0.43557382
74	Malaria_Homo sapiens_hsa05144	0.43167823
75	Retinol metabolism_Homo sapiens_hsa00830	0.42437471
76	Caffeine metabolism_Homo sapiens_hsa00232	0.40127095
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39626933
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39262655
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.39191026
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38812785
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38784959
82	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38585695
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38397193
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38115895
85	Mineral absorption_Homo sapiens_hsa04978	0.37720971
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.37528414
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37272793
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36263200
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36134665
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34704146
91	Lysosome_Homo sapiens_hsa04142	0.33405535
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31616915
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31370756
94	Phototransduction_Homo sapiens_hsa04744	0.30447195
95	Nicotine addiction_Homo sapiens_hsa05033	0.30442577
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.29458612
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28303892
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27765019
99	Olfactory transduction_Homo sapiens_hsa04740	0.27601174
100	Alcoholism_Homo sapiens_hsa05034	0.26932876
101	Peroxisome_Homo sapiens_hsa04146	0.26838447
102	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26776808
103	Type I diabetes mellitus_Homo sapiens_hsa04940	0.25692723
104	Serotonergic synapse_Homo sapiens_hsa04726	0.25339584
105	mRNA surveillance pathway_Homo sapiens_hsa03015	0.24759196
106	Oocyte meiosis_Homo sapiens_hsa04114	0.24606478
107	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23879065
108	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.22984687
109	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22709111
110	Carbon metabolism_Homo sapiens_hsa01200	0.22498884
111	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22386860
112	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21705698
113	Phenylalanine metabolism_Homo sapiens_hsa00360	0.21525262
114	Fat digestion and absorption_Homo sapiens_hsa04975	0.20109756
115	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.19424488
116	Taste transduction_Homo sapiens_hsa04742	0.19219484
117	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18439371
118	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.18322589
119	Legionellosis_Homo sapiens_hsa05134	0.17481039
120	p53 signaling pathway_Homo sapiens_hsa04115	0.16969343
121	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.15965943
122	Pentose phosphate pathway_Homo sapiens_hsa00030	0.15478905
123	Fatty acid degradation_Homo sapiens_hsa00071	0.14982772
124	Pertussis_Homo sapiens_hsa05133	0.12642098
125	One carbon pool by folate_Homo sapiens_hsa00670	0.12032824
126	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.11366840
127	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.08981683
128	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.08242923
129	Butanoate metabolism_Homo sapiens_hsa00650	0.07929066
130	Pyruvate metabolism_Homo sapiens_hsa00620	0.07586219
131	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.07583533
132	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.07091357

TMEM258

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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