TMEM259

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.33585736
2mannose metabolic process (GO:0006013)4.67822703
3lysine catabolic process (GO:0006554)4.60305479
4lysine metabolic process (GO:0006553)4.60305479
5regulation of cholesterol homeostasis (GO:2000188)4.40578460
6alpha-linolenic acid metabolic process (GO:0036109)4.31632615
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21146228
8L-phenylalanine metabolic process (GO:0006558)4.21146228
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.04261191
10L-phenylalanine catabolic process (GO:0006559)4.04261191
11regulation of fatty acid beta-oxidation (GO:0031998)4.01486892
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95217865
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90776083
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.86807023
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78965987
16negative regulation of fibrinolysis (GO:0051918)3.77426588
17kynurenine metabolic process (GO:0070189)3.69096757
18glyoxylate metabolic process (GO:0046487)3.65488492
19negative regulation of sterol transport (GO:0032372)3.62075173
20negative regulation of cholesterol transport (GO:0032375)3.62075173
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61082778
22positive regulation of histone deacetylation (GO:0031065)3.60938482
232-oxoglutarate metabolic process (GO:0006103)3.60247878
24sulfur amino acid catabolic process (GO:0000098)3.58986900
25antigen processing and presentation of endogenous antigen (GO:0019883)3.56640835
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55663909
27negative regulation of cell killing (GO:0031342)3.55663909
28cysteine metabolic process (GO:0006534)3.55477096
29positive regulation of triglyceride biosynthetic process (GO:0010867)3.52361116
30aromatic amino acid family catabolic process (GO:0009074)3.46499422
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.46023412
32urea cycle (GO:0000050)3.45864021
33urea metabolic process (GO:0019627)3.45864021
34response to muramyl dipeptide (GO:0032495)3.41755019
35positive regulation of triglyceride metabolic process (GO:0090208)3.41527676
36dicarboxylic acid biosynthetic process (GO:0043650)3.41402919
37regulation of triglyceride catabolic process (GO:0010896)3.39986221
38fatty acid transmembrane transport (GO:1902001)3.39620985
39aspartate family amino acid catabolic process (GO:0009068)3.39196627
40carnitine shuttle (GO:0006853)3.36690193
41thymic T cell selection (GO:0045061)3.31282686
42regulation of fatty acid oxidation (GO:0046320)3.29548127
43amino-acid betaine metabolic process (GO:0006577)3.29367816
44positive regulation of gamma-delta T cell activation (GO:0046645)3.26889186
45protein carboxylation (GO:0018214)3.26879176
46peptidyl-glutamic acid carboxylation (GO:0017187)3.26879176
47apoptotic process involved in morphogenesis (GO:0060561)3.25622208
48negative regulation of cell size (GO:0045792)3.23246980
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22424132
50maternal placenta development (GO:0001893)3.19433093
514-hydroxyproline metabolic process (GO:0019471)3.18992045
52complement activation, alternative pathway (GO:0006957)3.17362357
53regulation of cholesterol esterification (GO:0010872)3.17161422
54positive regulation of lipid catabolic process (GO:0050996)3.16787680
55NIK/NF-kappaB signaling (GO:0038061)3.15855493
56plasma lipoprotein particle clearance (GO:0034381)3.15384966
57positive regulation of fatty acid oxidation (GO:0046321)3.15362696
58fatty acid beta-oxidation (GO:0006635)3.14352175
59cellular modified amino acid catabolic process (GO:0042219)3.14176637
60regulation of ARF GTPase activity (GO:0032312)3.13456560
61acetyl-CoA metabolic process (GO:0006084)3.12852498
62nitrogen cycle metabolic process (GO:0071941)3.12680142
63valine metabolic process (GO:0006573)3.11370792
64regulation of fibrinolysis (GO:0051917)3.10120922
65low-density lipoprotein particle clearance (GO:0034383)3.08031403
66bile acid biosynthetic process (GO:0006699)3.07818808
67response to laminar fluid shear stress (GO:0034616)3.06906065
68serine family amino acid catabolic process (GO:0009071)3.05959059
69phospholipid efflux (GO:0033700)3.04843231
70high-density lipoprotein particle remodeling (GO:0034375)3.04144304
71glutamate metabolic process (GO:0006536)3.03719519
72modulation by symbiont of host cellular process (GO:0044068)3.03624097
73indole-containing compound catabolic process (GO:0042436)3.01444798
74indolalkylamine catabolic process (GO:0046218)3.01444798
75tryptophan catabolic process (GO:0006569)3.01444798
76regulation of extracellular matrix disassembly (GO:0010715)2.98963699
77negative regulation of lipid transport (GO:0032369)2.98748649
78ethanol oxidation (GO:0006069)2.98554123
79modulation by virus of host process (GO:0019054)2.98330324
80regulation of triglyceride biosynthetic process (GO:0010866)2.98261242
81homocysteine metabolic process (GO:0050667)2.97863169
82detection of bacterium (GO:0016045)2.96982639
83tricarboxylic acid metabolic process (GO:0072350)2.96807581
84regulation of cholesterol storage (GO:0010885)2.96600798
85protein-lipid complex assembly (GO:0065005)2.94605492
86regulation of protein activation cascade (GO:2000257)2.94365074
87positive regulation of Cdc42 GTPase activity (GO:0043089)2.94328805
88positive regulation by symbiont of host defense response (GO:0052509)2.91753429
89modulation by symbiont of host defense response (GO:0052031)2.91753429
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91753429
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91753429
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.91753429
93modulation by symbiont of host immune response (GO:0052553)2.91753429
94germinal center formation (GO:0002467)2.90615348
95carnitine transport (GO:0015879)2.90252616
96amino-acid betaine transport (GO:0015838)2.90252616
97semaphorin-plexin signaling pathway (GO:0071526)2.90049811
98fatty acid oxidation (GO:0019395)2.89818217
99response to peptidoglycan (GO:0032494)2.87546318
100detection of other organism (GO:0098543)2.86474095
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84094986
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83475727
103regulation of triglyceride metabolic process (GO:0090207)2.83308853
104lipid oxidation (GO:0034440)2.82280359
105carnitine transmembrane transport (GO:1902603)2.81036651
106activation of MAPKKK activity (GO:0000185)2.79588905
107regulation of complement activation (GO:0030449)2.78598990
108positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.78483290
109regulation of early endosome to late endosome transport (GO:2000641)2.77832211
110carnitine metabolic process (GO:0009437)2.77378110
111fatty acid catabolic process (GO:0009062)2.77268330
112regulation of fatty acid biosynthetic process (GO:0042304)2.76826282
113response to mercury ion (GO:0046689)2.76670600
114plasma lipoprotein particle assembly (GO:0034377)2.76507812
115alpha-amino acid catabolic process (GO:1901606)2.76380030
116activation of JUN kinase activity (GO:0007257)2.74956624
117phospholipid homeostasis (GO:0055091)2.74284674
118macrophage activation involved in immune response (GO:0002281)2.73454975
119acylglycerol homeostasis (GO:0055090)2.72992314
120triglyceride homeostasis (GO:0070328)2.72992314
121reverse cholesterol transport (GO:0043691)2.72796235
122regulation of glucose import in response to insulin stimulus (GO:2001273)2.72729212
123short-chain fatty acid metabolic process (GO:0046459)2.72659275
124activation of Rac GTPase activity (GO:0032863)2.71879870
125T cell selection (GO:0045058)2.69010142
126positive regulation of lipoprotein lipase activity (GO:0051006)2.68973377
127positive regulation of triglyceride lipase activity (GO:0061365)2.68973377
128tryptophan metabolic process (GO:0006568)2.68659890
129adherens junction assembly (GO:0034333)2.67687642
1303-UTR-mediated mRNA stabilization (GO:0070935)2.66764715
131cholesterol homeostasis (GO:0042632)2.66186059
132sterol homeostasis (GO:0055092)2.66124143
133monocarboxylic acid catabolic process (GO:0072329)2.66063320
134regulation of gamma-delta T cell activation (GO:0046643)2.65731187
135protein localization to endosome (GO:0036010)2.65148796
136drug catabolic process (GO:0042737)2.65142502
137glycine metabolic process (GO:0006544)2.64294592
138stress fiber assembly (GO:0043149)2.63849078
139cellular ketone body metabolic process (GO:0046950)2.62752361
140positive regulation of fatty acid metabolic process (GO:0045923)2.62721692
141cellular amino acid catabolic process (GO:0009063)2.62599439
142positive thymic T cell selection (GO:0045059)2.62291745
143bile acid metabolic process (GO:0008206)2.61820306
144leukocyte aggregation (GO:0070486)2.59706231
145focal adhesion assembly (GO:0048041)2.59580843
146cell-substrate adherens junction assembly (GO:0007045)2.59580843
147apoptotic cell clearance (GO:0043277)2.58893018
148signal complex assembly (GO:0007172)2.57495864
149barbed-end actin filament capping (GO:0051016)2.56906450
150negative regulation of myotube differentiation (GO:0010832)2.56304679
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55145151
152regulation of ARF protein signal transduction (GO:0032012)2.54920680
153regulation of gamma-delta T cell differentiation (GO:0045586)2.52725462
154embryonic process involved in female pregnancy (GO:0060136)2.51401006
155negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51351916
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49874950
157epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49490585
158regulation of histone H3-K27 methylation (GO:0061085)2.48365821
159histone H4 deacetylation (GO:0070933)2.47974860
160positive regulation of receptor recycling (GO:0001921)2.47617925
161regulation of leukocyte degranulation (GO:0043300)2.47393581
162cellular response to virus (GO:0098586)2.46479593
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46404477
164positive regulation of protein deacetylation (GO:0090312)2.46207849
165regulation of T-helper 2 cell differentiation (GO:0045628)2.43591602
166negative regulation of viral release from host cell (GO:1902187)2.43541995
167antigen processing and presentation via MHC class Ib (GO:0002475)2.42059363
168planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40939666
169negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39694704
170positive regulation of Rap GTPase activity (GO:0032854)2.39625716
171detection of external biotic stimulus (GO:0098581)2.38894628
172cell-cell junction maintenance (GO:0045217)2.37464964
173pinocytosis (GO:0006907)2.37196553
174negative thymic T cell selection (GO:0045060)2.36012613
175COPI coating of Golgi vesicle (GO:0048205)2.35695997
176Golgi transport vesicle coating (GO:0048200)2.35695997
177negative regulation of fatty acid transport (GO:2000192)2.35678198
178negative regulation of granulocyte differentiation (GO:0030853)2.34680211
179positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33440768
180protein retention in ER lumen (GO:0006621)2.32612270
181regulation of monocyte differentiation (GO:0045655)2.31752401
182regulation of necroptotic process (GO:0060544)2.31678264
183regulation of myeloid leukocyte mediated immunity (GO:0002886)2.31255802
184regulation of extracellular matrix organization (GO:1903053)2.30783896
185cell-substrate junction assembly (GO:0007044)2.30747637
186positive T cell selection (GO:0043368)2.30331446
187positive regulation of protein dephosphorylation (GO:0035307)2.29409999
188regulation of necrotic cell death (GO:0010939)2.29199763
189retrograde transport, endosome to Golgi (GO:0042147)2.28367089
190lipopolysaccharide-mediated signaling pathway (GO:0031663)2.28084818
191positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28043534
192regulation of NFAT protein import into nucleus (GO:0051532)2.27554144
193tolerance induction (GO:0002507)2.25991012
194response to type I interferon (GO:0034340)2.25198096
195regulation of mammary gland epithelial cell proliferation (GO:0033599)2.23533606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.21962276
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00664503
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.81330573
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.66537598
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.95962345
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70122459
7LXR_22292898_ChIP-Seq_THP-1_Human2.56294774
8MYC_22102868_ChIP-Seq_BL_Human2.50155364
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37497214
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35332547
11KDM2B_26808549_Chip-Seq_DND41_Human2.33787452
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.21652854
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.20878916
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19442341
15VDR_21846776_ChIP-Seq_THP-1_Human2.19279041
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.19161029
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18221848
18TCF7_22412390_ChIP-Seq_EML_Mouse2.09930342
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07684354
20ZNF263_19887448_ChIP-Seq_K562_Human2.06456613
21CLOCK_20551151_ChIP-Seq_293T_Human2.02833486
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01993871
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01536509
24RACK7_27058665_Chip-Seq_MCF-7_Human1.95548424
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88834916
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88424255
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72305397
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64480908
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.61907344
30KDM2B_26808549_Chip-Seq_K562_Human1.61557708
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.57575495
32MAF_26560356_Chip-Seq_TH1_Human1.54414489
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.53562536
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52308893
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50968484
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50926747
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48955378
38P68_20966046_ChIP-Seq_HELA_Human1.48503117
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46675052
40ATF3_27146783_Chip-Seq_COLON_Human1.46089626
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45639594
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44630338
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41998903
44UTX_26944678_Chip-Seq_JUKART_Human1.41439771
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40943131
46CREB1_26743006_Chip-Seq_LNCaP_Human1.38523615
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38409481
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37270028
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.36931984
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36548993
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36263054
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.35266229
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.29565005
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.29565005
55GATA1_19941826_ChIP-Seq_K562_Human1.29202658
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28252215
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28202836
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.28106543
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27577672
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27321213
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27316450
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26697258
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26584440
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26318569
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23429196
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22829143
67VDR_24763502_ChIP-Seq_THP-1_Human1.22137004
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20573254
69BCOR_27268052_Chip-Seq_Bcells_Human1.20362605
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19810304
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.19543078
72NCOR1_26117541_ChIP-Seq_K562_Human1.19331752
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19324576
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19150384
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18281693
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17672986
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17362624
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16975687
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.14217886
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13677766
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13638817
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.13585269
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13551358
84BCL6_27268052_Chip-Seq_Bcells_Human1.13392613
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12988441
86TP53_22127205_ChIP-Seq_IMR90_Human1.12790066
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12758543
88SPI1_23127762_ChIP-Seq_K562_Human1.12015312
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11517431
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.11357053
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10997946
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10848090
93MAF_26560356_Chip-Seq_TH2_Human1.10229103
94SMC4_20622854_ChIP-Seq_HELA_Human1.09728727
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09425588
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09273904
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09091374
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09003414
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.08732699
100CTCF_21964334_Chip-Seq_Bcells_Human1.07935137
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07544467
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06850979
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06550052
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06445487
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.05931742
106TP63_22573176_ChIP-Seq_HFKS_Human1.03076188
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02218409
108CTCF_27219007_Chip-Seq_Bcells_Human1.02036393
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.01210598
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.01091898
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00781046
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00606870
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.00264463
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99816106
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99779676
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99433496
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98759314
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98589364
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97964063
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97433831
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96161059
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95377495
123SCL_19346495_ChIP-Seq_HPC-7_Human0.95351015
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94640382
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92999842
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92657056
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92467027
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91906044
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.90939122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.63828393
2MP0002139_abnormal_hepatobiliary_system4.45204116
3MP0003705_abnormal_hypodermis_morpholog3.95892684
4MP0009840_abnormal_foam_cell3.44186987
5MP0005085_abnormal_gallbladder_physiolo3.21445088
6MP0005365_abnormal_bile_salt3.10787377
7MP0003172_abnormal_lysosome_physiology2.82161881
8MP0003252_abnormal_bile_duct2.74207441
9MP0003191_abnormal_cellular_cholesterol2.54567119
10MP0008260_abnormal_autophagy2.47040294
11MP0010329_abnormal_lipoprotein_level2.37990029
12MP0008875_abnormal_xenobiotic_pharmacok2.22713020
13MP0003300_gastrointestinal_ulcer2.19780787
14MP0005083_abnormal_biliary_tract2.19344056
15MP0003303_peritoneal_inflammation2.11809825
16MP0004130_abnormal_muscle_cell2.05992588
17MP0004185_abnormal_adipocyte_glucose1.90809099
18MP0005332_abnormal_amino_acid1.87172732
19MP0008961_abnormal_basal_metabolism1.86933032
20MP0003763_abnormal_thymus_physiology1.84902955
21MP0005666_abnormal_adipose_tissue1.81064128
22MP0000678_abnormal_parathyroid_gland1.72423598
23MP0008438_abnormal_cutaneous_collagen1.71477478
24MP0000751_myopathy1.70766019
25MP0005025_abnormal_response_to1.69127351
26MP0000609_abnormal_liver_physiology1.68824782
27MP0002419_abnormal_innate_immunity1.68666416
28MP0009333_abnormal_splenocyte_physiolog1.68593207
29MP0000858_altered_metastatic_potential1.68143592
30MP0003566_abnormal_cell_adhesion1.64643222
31MP0005670_abnormal_white_adipose1.64275228
32MP0001790_abnormal_immune_system1.62067892
33MP0005387_immune_system_phenotype1.62067892
34MP0005000_abnormal_immune_tolerance1.60474679
35MP0005409_darkened_coat_color1.57899618
36MP0001835_abnormal_antigen_presentation1.57815581
37MP0001533_abnormal_skeleton_physiology1.53570466
38MP0002118_abnormal_lipid_homeostasis1.51405081
39MP0005375_adipose_tissue_phenotype1.51303638
40MP0010234_abnormal_vibrissa_follicle1.50898892
41MP0001348_abnormal_lacrimal_gland1.47106569
42MP0001800_abnormal_humoral_immune1.46433881
43MP0004087_abnormal_muscle_fiber1.45497979
44MP0002998_abnormal_bone_remodeling1.44143478
45MP0010155_abnormal_intestine_physiology1.43730875
46MP0003806_abnormal_nucleotide_metabolis1.43478043
47MP0001873_stomach_inflammation1.42926550
48MP0009278_abnormal_bone_marrow1.41089101
49MP0003724_increased_susceptibility_to1.40842591
50MP0005330_cardiomyopathy1.39065355
51MP0002837_dystrophic_cardiac_calcinosis1.38293936
52MP0001666_abnormal_nutrient_absorption1.37474150
53MP0002933_joint_inflammation1.37302619
54MP0002420_abnormal_adaptive_immunity1.33573626
55MP0002723_abnormal_immune_serum1.33472882
56MP0001819_abnormal_immune_cell1.32982773
57MP0002396_abnormal_hematopoietic_system1.32665360
58MP0002452_abnormal_antigen_presenting1.30736827
59MP0005076_abnormal_cell_differentiation1.29924256
60MP0000747_muscle_weakness1.28881178
61MP0005319_abnormal_enzyme/_coenzyme1.28809700
62MP0009643_abnormal_urine_homeostasis1.28362065
63MP0002249_abnormal_larynx_morphology1.28011857
64MP0002877_abnormal_melanocyte_morpholog1.25648300
65MP0002796_impaired_skin_barrier1.23762602
66MP0004084_abnormal_cardiac_muscle1.22643632
67MP0010630_abnormal_cardiac_muscle1.22331831
68MP0002405_respiratory_system_inflammati1.18090751
69MP0000733_abnormal_muscle_development1.17882908
70MP0004510_myositis1.16769666
71MP0010352_gastrointestinal_tract_polyps1.16074786
72MP0002269_muscular_atrophy1.15255780
73MP0000003_abnormal_adipose_tissue1.14418422
74MP0002398_abnormal_bone_marrow1.13795813
75MP0005275_abnormal_skin_tensile1.13520436
76MP0001545_abnormal_hematopoietic_system1.13483491
77MP0005397_hematopoietic_system_phenotyp1.13483491
78MP0003195_calcinosis1.12857045
79MP0005584_abnormal_enzyme/coenzyme_acti1.10012060
80MP0000716_abnormal_immune_system1.09806413
81MP0003279_aneurysm1.08671359
82MP0003646_muscle_fatigue1.08267371
83MP0002971_abnormal_brown_adipose1.07277096
84MP0006082_CNS_inflammation1.06471132
85MP0003329_amyloid_beta_deposits1.06192948
86MP0005671_abnormal_response_to1.05773402
87MP0004019_abnormal_vitamin_homeostasis1.05654363
88MP0001849_ear_inflammation1.05375056
89MP0000598_abnormal_liver_morphology1.04191197
90MP0005451_abnormal_body_composition1.04147697
91MP0004381_abnormal_hair_follicle1.03448047
92MP0000604_amyloidosis1.03225170
93MP0009785_altered_susceptibility_to1.02665255
94MP0005023_abnormal_wound_healing1.02111194
95MP0000703_abnormal_thymus_morphology1.00258742
96MP0000749_muscle_degeneration0.99685697
97MP0001853_heart_inflammation0.98255606
98MP0000750_abnormal_muscle_regeneration0.97504735
99MP0001958_emphysema0.95250592
100MP0002138_abnormal_hepatobiliary_system0.95225685
101MP0005390_skeleton_phenotype0.95153899
102MP0002148_abnormal_hypersensitivity_rea0.95041001
103MP0002429_abnormal_blood_cell0.94549667
104MP0003828_pulmonary_edema0.94487327
105MP0001845_abnormal_inflammatory_respons0.94010891
106MP0004036_abnormal_muscle_relaxation0.93295538
107MP0003690_abnormal_glial_cell0.92760136
108MP0001851_eye_inflammation0.91507342
109MP0003866_abnormal_defecation0.91110458
110MP0002722_abnormal_immune_system0.90036137
111MP0005501_abnormal_skin_physiology0.89091448
112MP0005167_abnormal_blood-brain_barrier0.88699221
113MP0003075_altered_response_to0.88180552
114MP0000759_abnormal_skeletal_muscle0.87813276
115MP0005623_abnormal_meninges_morphology0.87556191
116MP0005058_abnormal_lysosome_morphology0.87052295
117MP0003183_abnormal_peptide_metabolism0.86474312
118MP0004808_abnormal_hematopoietic_stem0.86460237
119MP0003453_abnormal_keratinocyte_physiol0.86219607
120MP0003045_fibrosis0.86127727
121MP0002060_abnormal_skin_morphology0.84289742
122MP0004947_skin_inflammation0.83406417
123MP0010368_abnormal_lymphatic_system0.83368259
124MP0000685_abnormal_immune_system0.82652208
125MP0002254_reproductive_system_inflammat0.81862995
126MP0003283_abnormal_digestive_organ0.81132270
127MP0009384_cardiac_valve_regurgitation0.80275001
128MP0003091_abnormal_cell_migration0.79667800
129MP0008469_abnormal_protein_level0.79329456
130MP0000490_abnormal_crypts_of0.79097648
131MP0002089_abnormal_postnatal_growth/wei0.78736441
132MP0003448_altered_tumor_morphology0.78351059
133MP0005385_cardiovascular_system_phenoty0.78151728
134MP0001544_abnormal_cardiovascular_syste0.78151728
135MP0002136_abnormal_kidney_physiology0.76935095
136MP0006138_congestive_heart_failure0.75833302
137MP0009931_abnormal_skin_appearance0.75468917
138MP0001663_abnormal_digestive_system0.75464598
139MP0008775_abnormal_heart_ventricle0.75341927
140MP0009053_abnormal_anal_canal0.74955031
141MP0003656_abnormal_erythrocyte_physiolo0.74910725
142MP0001756_abnormal_urination0.74055127
143MP0000681_abnormal_thyroid_gland0.73445301
144MP0009115_abnormal_fat_cell0.72492316
145MP0004264_abnormal_extraembryonic_tissu0.72300453
146MP0003436_decreased_susceptibility_to0.71747411
147MP0005334_abnormal_fat_pad0.70917749
148MP0004858_abnormal_nervous_system0.69219960
149MP0000767_abnormal_smooth_muscle0.68787376
150MP0002970_abnormal_white_adipose0.68677646
151MP0002106_abnormal_muscle_physiology0.68599367
152MP0002128_abnormal_blood_circulation0.67599263
153MP0000013_abnormal_adipose_tissue0.67530735
154MP0005464_abnormal_platelet_physiology0.65999237
155MP0004272_abnormal_basement_membrane0.65934539
156MP0009672_abnormal_birth_weight0.64057843
157MP0002909_abnormal_adrenal_gland0.63807856
158MP0005166_decreased_susceptibility_to0.62368576
159MP0002078_abnormal_glucose_homeostasis0.60633131

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.47434665
2Xanthomatosis (HP:0000991)3.91463759
3Obstructive sleep apnea (HP:0002870)3.63092329
4Eczematoid dermatitis (HP:0000976)3.52389673
5Cerebral aneurysm (HP:0004944)3.19802066
6Broad face (HP:0000283)3.13899031
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08677924
8Complement deficiency (HP:0004431)3.05639948
9Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98216532
10Abnormality of the Achilles tendon (HP:0005109)2.90170181
11Protrusio acetabuli (HP:0003179)2.85773034
12Hyperlipoproteinemia (HP:0010980)2.84990483
13Ketosis (HP:0001946)2.82502563
14Intrahepatic cholestasis (HP:0001406)2.82379181
15Dysostosis multiplex (HP:0000943)2.72612164
16Increased connective tissue (HP:0009025)2.72491760
17Hyperammonemia (HP:0001987)2.71553436
18Myoglobinuria (HP:0002913)2.64664681
19Myocardial infarction (HP:0001658)2.64632426
20Increased IgE level (HP:0003212)2.64580430
21Achilles tendon contracture (HP:0001771)2.62895449
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60957849
23Hyporeflexia of lower limbs (HP:0002600)2.60570769
24Cellulitis (HP:0100658)2.59364210
25Colitis (HP:0002583)2.57351614
26Distal lower limb amyotrophy (HP:0008944)2.57294742
27Distal upper limb amyotrophy (HP:0007149)2.57274079
28Upper limb amyotrophy (HP:0009129)2.57274079
29Abnormality of complement system (HP:0005339)2.55639062
30Cervical subluxation (HP:0003308)2.53454404
31Polycythemia (HP:0001901)2.49921549
32Hypoalphalipoproteinemia (HP:0003233)2.48122876
33Hyperglycinuria (HP:0003108)2.47284454
34Broad metatarsal (HP:0001783)2.43622086
35Mitral valve prolapse (HP:0001634)2.40245907
36Stridor (HP:0010307)2.39589571
37Right ventricular cardiomyopathy (HP:0011663)2.39587973
38Hyperacusis (HP:0010780)2.36085891
39J-shaped sella turcica (HP:0002680)2.34739675
40Abnormality of macrophages (HP:0004311)2.33571323
41Shallow orbits (HP:0000586)2.32758045
42Lymphangioma (HP:0100764)2.32266217
43Difficulty climbing stairs (HP:0003551)2.32132653
44Ketoacidosis (HP:0001993)2.31991617
45Back pain (HP:0003418)2.31442087
46Difficulty running (HP:0009046)2.30568884
47Abnormality of fatty-acid metabolism (HP:0004359)2.30314246
48Vertebral compression fractures (HP:0002953)2.30171164
49Asymmetric septal hypertrophy (HP:0001670)2.29975351
50Emphysema (HP:0002097)2.24549206
51Sudden death (HP:0001699)2.23281823
52Systemic lupus erythematosus (HP:0002725)2.23113332
53Premature rupture of membranes (HP:0001788)2.22093325
54Mucopolysacchariduria (HP:0008155)2.21495595
55Urinary glycosaminoglycan excretion (HP:0003541)2.21495595
56Abnormality of glycine metabolism (HP:0010895)2.21303166
57Abnormality of serine family amino acid metabolism (HP:0010894)2.21303166
58Exercise-induced myalgia (HP:0003738)2.20839587
59Gastrointestinal inflammation (HP:0004386)2.20525888
60Recurrent abscess formation (HP:0002722)2.20472748
61Abnormality of polysaccharide metabolism (HP:0011012)2.18933601
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18933601
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18933601
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.18734978
65Recurrent bacterial skin infections (HP:0005406)2.18717442
66Aneurysm (HP:0002617)2.18588372
67Gingivitis (HP:0000230)2.17566184
68Muscle fiber splitting (HP:0003555)2.17353000
69Abnormality of the thoracic spine (HP:0100711)2.16514036
70Turricephaly (HP:0000262)2.15830196
71Mitral regurgitation (HP:0001653)2.14625424
72Gout (HP:0001997)2.14595188
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.14592275
74Biconcave vertebral bodies (HP:0004586)2.13901855
75Reticulocytosis (HP:0001923)2.13896739
76Chronic obstructive pulmonary disease (HP:0006510)2.13298302
77Obstructive lung disease (HP:0006536)2.13298302
78Type 1 muscle fiber predominance (HP:0003803)2.12028323
79Nuclear cataract (HP:0100018)2.10736873
80Abnormality of the fingertips (HP:0001211)2.09924784
81Epidermoid cyst (HP:0200040)2.09435938
82Hypolipoproteinemia (HP:0010981)2.09364964
83Peritonitis (HP:0002586)2.07915890
84Spastic diplegia (HP:0001264)2.07190558
85Long toe (HP:0010511)2.06903857
86Hypobetalipoproteinemia (HP:0003563)2.05406611
87Polygenic inheritance (HP:0010982)2.04504505
88Distal lower limb muscle weakness (HP:0009053)2.04409380
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03237827
90Hypoglycemic coma (HP:0001325)2.02007014
91Flat acetabular roof (HP:0003180)2.01987197
92Hand muscle atrophy (HP:0009130)2.01534043
93Axonal loss (HP:0003447)2.00887423
94Segmental peripheral demyelination/remyelination (HP:0003481)2.00204761
95Increased variability in muscle fiber diameter (HP:0003557)1.99086399
96Hypercholesterolemia (HP:0003124)1.98901265
97Neurofibrillary tangles (HP:0002185)1.98651286
98Thoracic kyphosis (HP:0002942)1.98405830
99Metaphyseal cupping (HP:0003021)1.98125242
100Exercise-induced muscle cramps (HP:0003710)1.97915718
101Myositis (HP:0100614)1.97538738
102Late onset (HP:0003584)1.97426343
103Ventricular tachycardia (HP:0004756)1.96998878
104Cholelithiasis (HP:0001081)1.96549120
105Joint stiffness (HP:0001387)1.96500416
106Mediastinal lymphadenopathy (HP:0100721)1.95993357
107Abnormality of the nasal mucosa (HP:0000433)1.95752624
108Interstitial pulmonary disease (HP:0006530)1.95655851
109Joint hemorrhage (HP:0005261)1.95601850
110Neonatal onset (HP:0003623)1.95431145
111Increased cerebral lipofuscin (HP:0011813)1.94512888
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93147022
113Easy fatigability (HP:0003388)1.92717870
114Gastrointestinal stroma tumor (HP:0100723)1.92549930
115Long palpebral fissure (HP:0000637)1.92103657
116Inflammation of the large intestine (HP:0002037)1.91733287
117Ulnar bowing (HP:0003031)1.90990414
118Abnormality of the common coagulation pathway (HP:0010990)1.90272272
119Hypertriglyceridemia (HP:0002155)1.88636458
120Supranuclear gaze palsy (HP:0000605)1.88610543
121Fragile skin (HP:0001030)1.88023550
122Cerebral inclusion bodies (HP:0100314)1.87692300
123Abnormality of the lower motor neuron (HP:0002366)1.87184545
124Loss of speech (HP:0002371)1.86589723
125Rectal prolapse (HP:0002035)1.86330107
126Hemorrhage of the eye (HP:0011885)1.85925364
127Hypertensive crisis (HP:0100735)1.85766527
128Recurrent gram-negative bacterial infections (HP:0005420)1.85604256
129Atrioventricular block (HP:0001678)1.84338307
130Neuronal loss in central nervous system (HP:0002529)1.83461093
131Abnormality of liposaccharide metabolism (HP:0010968)1.83253761
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.83253761
133Abnormality of glycolipid metabolism (HP:0010969)1.83253761
134Nasal polyposis (HP:0100582)1.82526652
135Skin nodule (HP:0200036)1.82398184
136Bundle branch block (HP:0011710)1.82351951
137Malnutrition (HP:0004395)1.81957368
138Mitral stenosis (HP:0001718)1.81601328
139Hepatocellular carcinoma (HP:0001402)1.81238820
140Gastrointestinal infarctions (HP:0005244)1.79960257
141Frequent falls (HP:0002359)1.79954919
142Dysmetric saccades (HP:0000641)1.79269929
143Abnormality of skeletal muscle fiber size (HP:0012084)1.78597457
144Esophageal varix (HP:0002040)1.78510346
145Disproportionate tall stature (HP:0001519)1.78235415
146Rhabdomyolysis (HP:0003201)1.78172054
147Thin bony cortex (HP:0002753)1.77864520
148Mildly elevated creatine phosphokinase (HP:0008180)1.77698072
149Blue sclerae (HP:0000592)1.77245167
150Atrophic scars (HP:0001075)1.74942228
151Abnormality of purine metabolism (HP:0004352)1.74887004
152Hyperglycinemia (HP:0002154)1.74592092
153Meningitis (HP:0001287)1.74128629
154Abnormal cartilage morphology (HP:0002763)1.73120777
155Atelectasis (HP:0100750)1.71346468
156Pseudobulbar signs (HP:0002200)1.71339383
157Mesangial abnormality (HP:0001966)1.71221842
158Pustule (HP:0200039)1.70399293
159Aortic aneurysm (HP:0004942)1.70317540
160Annular pancreas (HP:0001734)1.70291671
161Round ear (HP:0100830)1.69324076
162Myopathic facies (HP:0002058)1.69102646
163Purpura (HP:0000979)1.68926608
164Abnormal gallbladder morphology (HP:0012437)1.68475574
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68011377
166Lower limb amyotrophy (HP:0007210)1.67811085
167Ankle contracture (HP:0006466)1.67637160
168Dilatation of the ascending aorta (HP:0005111)1.67599798
169Insomnia (HP:0100785)1.66485657
170Spontaneous hematomas (HP:0007420)1.65962170
171Impaired platelet aggregation (HP:0003540)1.65780743
172Abnormal platelet function (HP:0011869)1.65780743
173Onion bulb formation (HP:0003383)1.63371715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.31299812
2PKN24.09958154
3ERN13.38580766
4PRPF4B3.36231868
5EEF2K3.00985346
6MAP3K102.88463354
7SMG12.85950787
8TTN2.80175385
9SIK12.49941400
10RIPK12.02636920
11PTK61.99120022
12ICK1.97303543
13BCKDK1.93873246
14FGFR41.92406410
15IRAK31.86672526
16MAP3K131.83288276
17MAP4K11.79942196
18RIPK41.78466957
19TAOK11.76062641
20EPHB11.54843741
21MAP3K71.51943887
22PDGFRA1.51571230
23BMX1.45310520
24LRRK21.42944848
25NME21.42913043
26TNK21.42188508
27CDK121.31008780
28DMPK1.29937288
29MAP2K31.22429458
30TAOK21.11747365
31GRK61.09674408
32SIK31.09524886
33IRAK41.09454783
34MAP3K141.08400554
35MST1R1.04809265
36MTOR1.02530339
37SIK21.01755923
38MAP3K60.99853824
39ALK0.99793553
40DDR20.98965626
41TGFBR20.98412031
42EPHA20.97598430
43PRKD30.95836174
44CAMK1D0.95681672
45LMTK20.94479863
46CAMK1G0.93761608
47TYRO30.93131476
48PRKD20.92842399
49PTK20.91568902
50MAP3K110.87470482
51KSR20.87328040
52PRKCH0.86424890
53HIPK20.86394707
54PAK20.85355785
55LATS10.84588418
56FLT30.84103698
57FES0.83758120
58TESK10.83687061
59PAK40.83451725
60TYK20.82095734
61RET0.81172334
62STK380.81150864
63ZAP700.80422881
64DYRK1B0.79270752
65PHKG10.79103392
66PHKG20.79103392
67JAK10.77694361
68PRKD10.75718809
69MAPK110.74705637
70CDK60.74646322
71CSK0.74479721
72TBK10.74425159
73JAK20.73784109
74PDPK10.71839558
75ARAF0.69086289
76MAP2K20.68626750
77KDR0.66356279
78ILK0.65376116
79IRAK20.65236299
80MARK20.64395889
81MAPK70.64138703
82STK100.63738640
83SCYL20.63545940
84MAP2K60.63383209
85CAMKK10.63320480
86CDK40.62560590
87MAPK150.60555131
88HCK0.60369960
89PDK40.59856788
90PDK30.59856788
91PDK10.59571822
92DAPK30.59226797
93PAK60.58425597
94PDGFRB0.57687924
95IKBKE0.57122616
96MAP3K80.57090140
97STK110.55252188
98BLK0.54371403
99MAP3K10.52966294
100MAPK120.52921760
101PRKAA20.51825073
102TAOK30.51312245
103TESK20.50778163
104FGFR30.49820540
105NEK10.49023895
106DAPK20.48567023
107RPS6KA10.48358138
108RPS6KA20.46745627
109MAP3K30.46214656
110ITK0.45386561
111NEK20.45035707
112LATS20.44875793
113NTRK10.44005389
114MAP3K20.42982360
115MAPKAPK30.42644400
116WNK40.42333345
117CDC42BPA0.40884652
118FGR0.40469497
119LCK0.40181267
120IKBKB0.40163230
121BRAF0.40066696
122GSK3A0.39825237
123RPS6KL10.39525081
124RPS6KC10.39525081
125PRKAA10.39426458
126BTK0.38603371
127MAPK40.38562162
128RPS6KA60.38213197
129JAK30.37756576
130SYK0.37397102
131SGK30.37360100
132PRKG20.35868343
133CSF1R0.35703206
134MOS0.34268794

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.71087645
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35533752
3Other glycan degradation_Homo sapiens_hsa005113.22865392
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.84916019
5Arginine biosynthesis_Homo sapiens_hsa002202.69913334
6Fatty acid degradation_Homo sapiens_hsa000712.55853734
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52198503
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35371558
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29259273
10PPAR signaling pathway_Homo sapiens_hsa033202.08866104
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01211225
12Tryptophan metabolism_Homo sapiens_hsa003801.98273325
13Fatty acid metabolism_Homo sapiens_hsa012121.86699875
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77942218
15Bile secretion_Homo sapiens_hsa049761.77046005
16Propanoate metabolism_Homo sapiens_hsa006401.76399340
17Complement and coagulation cascades_Homo sapiens_hsa046101.73165264
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70373303
19Lysine degradation_Homo sapiens_hsa003101.69398905
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.69233924
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61823808
22Leishmaniasis_Homo sapiens_hsa051401.57871933
23Butanoate metabolism_Homo sapiens_hsa006501.56520052
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45654284
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43563590
26Carbon metabolism_Homo sapiens_hsa012001.42751029
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42311825
28Sulfur relay system_Homo sapiens_hsa041221.29823351
29Staphylococcus aureus infection_Homo sapiens_hsa051501.29464913
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.29173705
31Biosynthesis of amino acids_Homo sapiens_hsa012301.27708284
32Toxoplasmosis_Homo sapiens_hsa051451.26399829
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24549842
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.24416066
35Pyruvate metabolism_Homo sapiens_hsa006201.24383671
36beta-Alanine metabolism_Homo sapiens_hsa004101.22572976
37TNF signaling pathway_Homo sapiens_hsa046681.21355830
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20125614
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.19669027
40T cell receptor signaling pathway_Homo sapiens_hsa046601.19048205
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.18168507
42Insulin resistance_Homo sapiens_hsa049311.17925820
43Fat digestion and absorption_Homo sapiens_hsa049751.17815766
44Caffeine metabolism_Homo sapiens_hsa002321.16298482
45GnRH signaling pathway_Homo sapiens_hsa049121.13975778
46Influenza A_Homo sapiens_hsa051641.13975207
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.13751353
48Tuberculosis_Homo sapiens_hsa051521.11671904
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11412891
50Hepatitis C_Homo sapiens_hsa051601.10768238
51ABC transporters_Homo sapiens_hsa020101.10201724
52Peroxisome_Homo sapiens_hsa041461.10082694
53Lysosome_Homo sapiens_hsa041421.05944301
54Choline metabolism in cancer_Homo sapiens_hsa052311.01920492
55Hepatitis B_Homo sapiens_hsa051611.01425110
56Starch and sucrose metabolism_Homo sapiens_hsa005001.01117942
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00886495
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96937670
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95487909
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95209808
61Bladder cancer_Homo sapiens_hsa052190.94805818
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94677818
63Selenocompound metabolism_Homo sapiens_hsa004500.93810397
64Prolactin signaling pathway_Homo sapiens_hsa049170.93667222
65ErbB signaling pathway_Homo sapiens_hsa040120.93051889
66Viral myocarditis_Homo sapiens_hsa054160.92057155
67Allograft rejection_Homo sapiens_hsa053300.91011692
68Apoptosis_Homo sapiens_hsa042100.90506027
69Chronic myeloid leukemia_Homo sapiens_hsa052200.90186680
70Glycerolipid metabolism_Homo sapiens_hsa005610.89802682
71Herpes simplex infection_Homo sapiens_hsa051680.88899883
72Pertussis_Homo sapiens_hsa051330.88400545
73Fatty acid biosynthesis_Homo sapiens_hsa000610.88144370
74Chemokine signaling pathway_Homo sapiens_hsa040620.86437233
75AMPK signaling pathway_Homo sapiens_hsa041520.84390969
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.83966489
77Measles_Homo sapiens_hsa051620.83850383
78Primary immunodeficiency_Homo sapiens_hsa053400.82115007
79Autoimmune thyroid disease_Homo sapiens_hsa053200.81767299
80Malaria_Homo sapiens_hsa051440.81151256
81Endocytosis_Homo sapiens_hsa041440.81091376
82HTLV-I infection_Homo sapiens_hsa051660.81001482
83Inositol phosphate metabolism_Homo sapiens_hsa005620.80519990
84Estrogen signaling pathway_Homo sapiens_hsa049150.79428920
85Graft-versus-host disease_Homo sapiens_hsa053320.79415197
86Insulin signaling pathway_Homo sapiens_hsa049100.76131345
87Histidine metabolism_Homo sapiens_hsa003400.75741887
88Chemical carcinogenesis_Homo sapiens_hsa052040.74844156
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.74666881
90Phenylalanine metabolism_Homo sapiens_hsa003600.74161339
91Acute myeloid leukemia_Homo sapiens_hsa052210.73761329
92Salmonella infection_Homo sapiens_hsa051320.72103032
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71450280
94Colorectal cancer_Homo sapiens_hsa052100.71037888
95mTOR signaling pathway_Homo sapiens_hsa041500.70975835
96Shigellosis_Homo sapiens_hsa051310.69066815
97Glucagon signaling pathway_Homo sapiens_hsa049220.68810663
98Thyroid cancer_Homo sapiens_hsa052160.68747910
99Non-small cell lung cancer_Homo sapiens_hsa052230.67851513
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.67445902
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66765522
102Prostate cancer_Homo sapiens_hsa052150.66186805
103VEGF signaling pathway_Homo sapiens_hsa043700.66172220
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65983735
105Focal adhesion_Homo sapiens_hsa045100.65841661
106Arginine and proline metabolism_Homo sapiens_hsa003300.65772480
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64265582
108HIF-1 signaling pathway_Homo sapiens_hsa040660.64000734
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62052419
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61573278
111B cell receptor signaling pathway_Homo sapiens_hsa046620.61057977
112Amoebiasis_Homo sapiens_hsa051460.61046610
113Viral carcinogenesis_Homo sapiens_hsa052030.60741193
114Dilated cardiomyopathy_Homo sapiens_hsa054140.60659622
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.60574017
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60430783
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.59965212
118MAPK signaling pathway_Homo sapiens_hsa040100.59403055
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59272832
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.58013739
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57919765
122Long-term potentiation_Homo sapiens_hsa047200.57277867
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56865322
124Antigen processing and presentation_Homo sapiens_hsa046120.56278238
125Proteoglycans in cancer_Homo sapiens_hsa052050.55992709
126FoxO signaling pathway_Homo sapiens_hsa040680.54434790
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54051264
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53778482
129Prion diseases_Homo sapiens_hsa050200.53691770
130Pentose phosphate pathway_Homo sapiens_hsa000300.49463239
131Glioma_Homo sapiens_hsa052140.48742398
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47972633
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.47945125
134Small cell lung cancer_Homo sapiens_hsa052220.47177070
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46805962
136Type II diabetes mellitus_Homo sapiens_hsa049300.46422531
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46422382
138Notch signaling pathway_Homo sapiens_hsa043300.45914201
139Retinol metabolism_Homo sapiens_hsa008300.45903539
140ECM-receptor interaction_Homo sapiens_hsa045120.45394276
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44056423
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41632513
143Galactose metabolism_Homo sapiens_hsa000520.38824087
144Tyrosine metabolism_Homo sapiens_hsa003500.37892093
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37848020
146Protein digestion and absorption_Homo sapiens_hsa049740.37524857
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.37226228
148Endometrial cancer_Homo sapiens_hsa052130.35856481
149Osteoclast differentiation_Homo sapiens_hsa043800.35212864
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35065507
151Fructose and mannose metabolism_Homo sapiens_hsa000510.34666907
152Pancreatic cancer_Homo sapiens_hsa052120.34543057
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34519872
154Platelet activation_Homo sapiens_hsa046110.34464467
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34325617
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34100344
157Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34099008
158Renal cell carcinoma_Homo sapiens_hsa052110.33469626

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