TMEM26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)9.29325653
2cellular response to gonadotropin stimulus (GO:0071371)8.10524089
3diaphragm development (GO:0060539)7.75098673
4response to follicle-stimulating hormone (GO:0032354)7.42704308
5regulation of male gonad development (GO:2000018)7.27324858
6regulation of female gonad development (GO:2000194)7.12668970
7skeletal muscle organ development (GO:0060538)7.01920567
8regulation of cardioblast differentiation (GO:0051890)6.85346944
9negative regulation of metanephros development (GO:0072217)6.76451640
10parturition (GO:0007567)6.66046288
11glomerular basement membrane development (GO:0032836)6.20907592
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.14017517
13negative regulation of macrophage differentiation (GO:0045650)6.10750990
14atrioventricular valve morphogenesis (GO:0003181)5.97164066
15response to gonadotropin (GO:0034698)5.96469678
16head development (GO:0060322)5.89321010
17regulation of cell proliferation involved in kidney development (GO:1901722)5.68701683
18regulation of gonadotropin secretion (GO:0032276)5.66448110
19endocardial cushion development (GO:0003197)5.65885127
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.58958629
21glomerulus development (GO:0032835)5.47433199
22muscle cell fate commitment (GO:0042693)5.42024769
23glomerular filtration (GO:0003094)5.21913257
24regulation of glomerulus development (GO:0090192)5.07068584
25positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.96638750
26mesonephros development (GO:0001823)4.92135071
27seminiferous tubule development (GO:0072520)4.75485767
28regulation of non-canonical Wnt signaling pathway (GO:2000050)4.75280788
29negative regulation of B cell apoptotic process (GO:0002903)4.73768798
30C21-steroid hormone biosynthetic process (GO:0006700)4.68684592
31positive regulation of metanephros development (GO:0072216)4.62844704
32planar cell polarity pathway involved in neural tube closure (GO:0090179)4.62603109
33renal filtration (GO:0097205)4.55627813
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.53809356
35adhesion of symbiont to host (GO:0044406)4.52876722
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.52762641
37epithelial cell differentiation involved in kidney development (GO:0035850)4.49435676
38negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.48493419
39cardiac right ventricle morphogenesis (GO:0003215)4.43986219
40epithelial cell fate commitment (GO:0072148)4.34656488
41embryonic foregut morphogenesis (GO:0048617)4.34314337
42cell proliferation involved in metanephros development (GO:0072203)4.30799969
43metanephric epithelium development (GO:0072207)4.29109759
44virion attachment to host cell (GO:0019062)4.28631837
45adhesion of symbiont to host cell (GO:0044650)4.28631837
46negative regulation of T-helper cell differentiation (GO:0045623)4.19443391
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.19443391
48sex determination (GO:0007530)4.17854886
49middle ear morphogenesis (GO:0042474)4.10989298
50midgut development (GO:0007494)4.08097946
51negative regulation of axon extension involved in axon guidance (GO:0048843)4.07773946
52mesenchymal to epithelial transition (GO:0060231)4.06639114
53axon extension involved in axon guidance (GO:0048846)4.06623958
54neuron projection extension involved in neuron projection guidance (GO:1902284)4.06623958
55negative regulation of kidney development (GO:0090185)3.99749373
56bone trabecula formation (GO:0060346)3.99531355
57Leydig cell differentiation (GO:0033327)3.97879937
58positive regulation of heart growth (GO:0060421)3.94813060
59chondrocyte development (GO:0002063)3.94280826
60body morphogenesis (GO:0010171)3.82641909
61atrial septum morphogenesis (GO:0060413)3.81501784
62regulation of cardiac muscle cell contraction (GO:0086004)3.80365318
63negative regulation of alpha-beta T cell differentiation (GO:0046639)3.78726821
64cell-cell junction maintenance (GO:0045217)3.77951152
65craniofacial suture morphogenesis (GO:0097094)3.77866675
66embryonic cranial skeleton morphogenesis (GO:0048701)3.77107682
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74136174
68lateral sprouting from an epithelium (GO:0060601)3.72766192
69positive regulation of catenin import into nucleus (GO:0035413)3.70857114
70metanephric mesenchyme development (GO:0072075)3.68478542
71immunoglobulin mediated immune response (GO:0016064)3.67126847
72cell migration involved in heart development (GO:0060973)3.66080046
73regulation of interleukin-8 biosynthetic process (GO:0045414)3.62492285
74NLS-bearing protein import into nucleus (GO:0006607)3.62462244
75cardiac muscle hypertrophy in response to stress (GO:0014898)3.60571965
76muscle hypertrophy in response to stress (GO:0003299)3.60571965
77cardiac muscle adaptation (GO:0014887)3.60571965
78positive regulation of mesonephros development (GO:0061213)3.55740044
79regulation of cholesterol storage (GO:0010885)3.55166425
80negative regulation of axon guidance (GO:1902668)3.54764744
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.51609053
82convergent extension (GO:0060026)3.49542848
83exocrine pancreas development (GO:0031017)3.46101532
84adrenal gland development (GO:0030325)3.46036513
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.45518378
86hemoglobin metabolic process (GO:0020027)3.42812296
87prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.42086494
88regulation of axon extension involved in axon guidance (GO:0048841)3.41514820
89apoptotic cell clearance (GO:0043277)3.40853343
90regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.36948175
91negative chemotaxis (GO:0050919)3.36875350
92negative regulation of digestive system process (GO:0060457)3.35797645
93kidney mesenchyme development (GO:0072074)3.34632826
94cranial suture morphogenesis (GO:0060363)3.33052304
95positive regulation vascular endothelial growth factor production (GO:0010575)3.32719020
96regulation of mononuclear cell migration (GO:0071675)3.32465633
97Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.32313523
98regulation of establishment of planar polarity (GO:0090175)3.31988438
99regulation of mesenchymal cell apoptotic process (GO:2001053)3.27654251
100male genitalia development (GO:0030539)3.27539526
101sequestering of extracellular ligand from receptor (GO:0035581)3.25344671
102outer ear morphogenesis (GO:0042473)3.24296602
103bone morphogenesis (GO:0060349)3.24278107
104regulation of interferon-gamma biosynthetic process (GO:0045072)3.22210408
105glucocorticoid biosynthetic process (GO:0006704)3.21942719
106eosinophil chemotaxis (GO:0048245)3.19484694
107negative regulation of cell fate specification (GO:0009996)3.18730020
108hindlimb morphogenesis (GO:0035137)3.17613630
109cell proliferation involved in kidney development (GO:0072111)3.17428588
110regulation of vascular endothelial growth factor production (GO:0010574)3.17160064
111branching involved in prostate gland morphogenesis (GO:0060442)3.15719426
112positive regulation of mesenchymal cell proliferation (GO:0002053)3.15564772
113regulation of T-helper 2 cell differentiation (GO:0045628)3.15236160
114regulation of axon guidance (GO:1902667)3.15009939
115embryonic hindlimb morphogenesis (GO:0035116)3.14450886
116hippo signaling (GO:0035329)3.14299374
117embryonic skeletal joint morphogenesis (GO:0060272)3.13218157
118negative regulation of DNA repair (GO:0045738)3.13078211
119glycosphingolipid catabolic process (GO:0046479)3.12847340
120chondrocyte proliferation (GO:0035988)3.11539992
121mitotic sister chromatid cohesion (GO:0007064)3.09881008
122negative regulation of fatty acid transport (GO:2000192)3.09576820
123oligosaccharide catabolic process (GO:0009313)3.08870494
124SMAD protein signal transduction (GO:0060395)3.08475052
125regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.08124737
126glial cell migration (GO:0008347)3.07787416
127regulation of metanephros development (GO:0072215)3.07038121
128embryonic body morphogenesis (GO:0010172)3.05772738
129labyrinthine layer development (GO:0060711)3.05514988
130eyelid development in camera-type eye (GO:0061029)3.03563322
131retinal cone cell development (GO:0046549)3.02664778
132cellular response to antibiotic (GO:0071236)3.02509712
133regulation of vitamin D biosynthetic process (GO:0060556)3.02500047
134glucocorticoid receptor signaling pathway (GO:0042921)3.01587900
135positive regulation of macrophage cytokine production (GO:0060907)3.00164790
136regulation of B cell apoptotic process (GO:0002902)2.99683275
137positive regulation of transcription regulatory region DNA binding (GO:2000679)2.99185980
138cellular response to interferon-alpha (GO:0035457)2.98417725
139regulation of fever generation (GO:0031620)2.97961511
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.96913569
141palate development (GO:0060021)2.95763058
142negative regulation of alpha-beta T cell activation (GO:0046636)2.94382546
143progesterone metabolic process (GO:0042448)2.94353692
144regulation of mesenchymal cell proliferation (GO:0010464)2.93894537
145mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.93328890
146mesenchymal cell proliferation (GO:0010463)2.92419590
147gastrulation with mouth forming second (GO:0001702)2.92266791
148endoderm formation (GO:0001706)2.92126673
149embryonic forelimb morphogenesis (GO:0035115)2.91082892
150keratan sulfate catabolic process (GO:0042340)2.90383929
151regulation of mitotic spindle organization (GO:0060236)2.90205753
152respiratory system process (GO:0003016)2.89018002
153positive regulation of heat generation (GO:0031652)2.87622881
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.87265050
155anatomical structure regression (GO:0060033)2.86595265
156histamine secretion (GO:0001821)2.86440865
157positive regulation of organ growth (GO:0046622)2.85787841
158regulation of heart morphogenesis (GO:2000826)2.85747363
159patterning of blood vessels (GO:0001569)2.85600774
160eosinophil migration (GO:0072677)2.85521810
161regulation of catenin import into nucleus (GO:0035412)2.85402316
162regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85010027
163cardiac muscle hypertrophy (GO:0003300)2.84235670
164collagen fibril organization (GO:0030199)2.83330281
165regulation of interferon-beta biosynthetic process (GO:0045357)2.83227573
166cell junction maintenance (GO:0034331)2.82905210
167low-density lipoprotein particle clearance (GO:0034383)2.82456646
168extracellular regulation of signal transduction (GO:1900115)2.81387724
169extracellular negative regulation of signal transduction (GO:1900116)2.81387724
170regulation of actin filament-based movement (GO:1903115)2.80762998
171regulation of macrophage cytokine production (GO:0010935)2.80073613
172mesenchymal-epithelial cell signaling (GO:0060638)2.78831222
173T cell apoptotic process (GO:0070231)2.78641075
174cochlea morphogenesis (GO:0090103)2.77871187
175positive regulation of odontogenesis (GO:0042482)2.77381821
176glycolipid catabolic process (GO:0019377)2.77108454
177regulation of mesonephros development (GO:0061217)2.76361367
178regulation of receptor binding (GO:1900120)2.75682803
179appendage morphogenesis (GO:0035107)2.75200297
180limb morphogenesis (GO:0035108)2.75200297
181epithelial cell-cell adhesion (GO:0090136)2.75160272
182negative regulation of chondrocyte differentiation (GO:0032331)2.73480223
183fusion of sperm to egg plasma membrane (GO:0007342)2.69959517
184regulation of macrophage differentiation (GO:0045649)2.69697301
185positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68109606
186negative regulation of reproductive process (GO:2000242)2.67871827
187cellular response to cadmium ion (GO:0071276)2.66253599
188regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64386527
189glucocorticoid metabolic process (GO:0008211)2.64221817
190striated muscle hypertrophy (GO:0014897)2.63771137
191muscle hypertrophy (GO:0014896)2.62667024
192vitamin D metabolic process (GO:0042359)2.62053176
193positive regulation of kidney development (GO:0090184)2.61373016
194cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.4275213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.98417578
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.62482416
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.85215898
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.66817021
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45097044
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21300433
7WT1_19549856_ChIP-ChIP_CCG9911_Human3.08948981
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83364144
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.75978921
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70282576
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.67203262
12* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60362044
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.46820120
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25611378
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.24703007
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24345640
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24345640
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24345640
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20537287
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12150415
21VDR_24787735_ChIP-Seq_THP-1_Human2.07538173
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06765493
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04328385
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01379014
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00011965
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.87135606
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.81261475
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.79599726
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77720752
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77475851
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76956535
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.68772103
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.64135530
34TP53_18474530_ChIP-ChIP_U2OS_Human1.60665574
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.60476646
36ZNF274_21170338_ChIP-Seq_K562_Hela1.58857689
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58785138
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58785138
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57378735
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.57053568
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53512196
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.53405018
43GATA1_22025678_ChIP-Seq_K562_Human1.51828522
44CLOCK_20551151_ChIP-Seq_293T_Human1.51540025
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50285469
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49448848
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48461750
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45610316
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45521370
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45521370
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.45306663
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45238235
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.44336461
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43651933
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43086956
56BRD4_25478319_ChIP-Seq_HGPS_Human1.42923336
57* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42393178
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40963151
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40855936
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39597255
61EWS_26573619_Chip-Seq_HEK293_Human1.37725105
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37447164
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.37176606
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36477124
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35075440
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33862475
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33167771
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32741493
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32720066
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32454784
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31828871
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.31375546
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.30280587
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29678358
75AHR_22903824_ChIP-Seq_MCF-7_Human1.29638980
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28893583
77SA1_22415368_ChIP-Seq_MEFs_Mouse1.28532770
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.25309664
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25252773
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24265985
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23460288
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.23234453
83KDM2B_26808549_Chip-Seq_K562_Human1.22823187
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22454009
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.21657433
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20541061
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19619624
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18756675
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17848885
90* CJUN_26792858_Chip-Seq_BT549_Human1.17554724
91GATA1_19941826_ChIP-Seq_K562_Human1.17394495
92IGF1R_20145208_ChIP-Seq_DFB_Human1.16293820
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16147752
94RXR_22108803_ChIP-Seq_LS180_Human1.15798285
95GF1_26923725_Chip-Seq_HPCs_Mouse1.15266080
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15153972
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14749341
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14123265
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13867463
100VDR_24763502_ChIP-Seq_THP-1_Human1.13783048
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13740008
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12524837
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10959241
104VDR_21846776_ChIP-Seq_THP-1_Human1.08169643
105SOX2_20726797_ChIP-Seq_SW620_Human1.07770246
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06652650
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06619021
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.04206062
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.04206062
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03689851
111E2F7_22180533_ChIP-Seq_HELA_Human1.02758534
112TP53_16413492_ChIP-PET_HCT116_Human1.02669100
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.02553770
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01989241
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00864422
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00383224
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.00208260
118GF1B_26923725_Chip-Seq_HPCs_Mouse0.99879049
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98488461
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98354516
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.97640461
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97567242
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96837178
124* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96059381
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95212618
126RXR_22158963_ChIP-Seq_LIVER_Mouse0.94555983
127EZH2_22144423_ChIP-Seq_EOC_Human0.94528803
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.94158805
129STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93627005
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.92999933
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92714819
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92337810
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92082982
134P300_19829295_ChIP-Seq_ESCs_Human0.91943207
135* BCAT_22108803_ChIP-Seq_LS180_Human0.91665929
136* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90032928
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90032562
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.89973543
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.88842114
140GBX2_23144817_ChIP-Seq_PC3_Human0.86966445
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86491147
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86428630
143MYC_22102868_ChIP-Seq_BL_Human0.85106030
144* ELK3_25401928_ChIP-Seq_HUVEC_Human0.83562006
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.83490671
146TP63_23658742_ChIP-Seq_EP156T_Human0.83428576
147PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81659593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.42895201
2MP0003122_maternal_imprinting4.24197295
3MP0005503_abnormal_tendon_morphology4.09324171
4MP0010030_abnormal_orbit_morphology3.89306855
5MP0009053_abnormal_anal_canal3.72531241
6MP0005058_abnormal_lysosome_morphology3.31570542
7MP0003385_abnormal_body_wall3.24185023
8MP0009840_abnormal_foam_cell3.13295486
9MP0008438_abnormal_cutaneous_collagen3.04239644
10MP0010386_abnormal_urinary_bladder3.03252342
11MP0008995_early_reproductive_senescence2.98689800
12MP0000639_abnormal_adrenal_gland2.71692284
13MP0001661_extended_life_span2.70876885
14MP0003123_paternal_imprinting2.67514527
15MP0005310_abnormal_salivary_gland2.64680881
16MP0009250_abnormal_appendicular_skeleto2.55118110
17MP0003705_abnormal_hypodermis_morpholog2.51458310
18MP0000049_abnormal_middle_ear2.46450717
19MP0006082_CNS_inflammation2.38662387
20MP0003191_abnormal_cellular_cholesterol2.35123681
21MP0003121_genomic_imprinting2.30515408
22MP0010368_abnormal_lymphatic_system2.29164605
23MP0003942_abnormal_urinary_system2.27405500
24MP0003941_abnormal_skin_development2.19884970
25MP0001853_heart_inflammation2.12103137
26MP0003315_abnormal_perineum_morphology2.10990677
27MP0002254_reproductive_system_inflammat2.10826055
28MP0005167_abnormal_blood-brain_barrier2.04489044
29MP0003755_abnormal_palate_morphology2.04366396
30MP0002938_white_spotting2.01426374
31MP0003937_abnormal_limbs/digits/tail_de1.99904869
32MP0000762_abnormal_tongue_morphology1.99578471
33MP0003300_gastrointestinal_ulcer1.94135405
34MP0003011_delayed_dark_adaptation1.93591026
35MP0000534_abnormal_ureter_morphology1.91374811
36MP0002249_abnormal_larynx_morphology1.90849661
37MP0009333_abnormal_splenocyte_physiolog1.87839779
38MP0003935_abnormal_craniofacial_develop1.86154450
39MP0003221_abnormal_cardiomyocyte_apopto1.85785708
40MP0006054_spinal_hemorrhage1.83628454
41MP0001542_abnormal_bone_strength1.82687839
42MP0000343_altered_response_to1.79983471
43MP0000537_abnormal_urethra_morphology1.78912049
44MP0009384_cardiac_valve_regurgitation1.71930367
45MP0004510_myositis1.71304662
46MP0002932_abnormal_joint_morphology1.70912679
47MP0000733_abnormal_muscle_development1.68251211
48MP0000428_abnormal_craniofacial_morphol1.65506929
49MP0005187_abnormal_penis_morphology1.62958471
50MP0006138_congestive_heart_failure1.62945393
51MP0003279_aneurysm1.62390073
52MP0005257_abnormal_intraocular_pressure1.58638253
53MP0004272_abnormal_basement_membrane1.58391394
54MP0001293_anophthalmia1.58355664
55MP0001270_distended_abdomen1.55698680
56MP0005275_abnormal_skin_tensile1.52982893
57MP0002233_abnormal_nose_morphology1.52863294
58MP0001958_emphysema1.51735538
59MP0002115_abnormal_skeleton_extremities1.48283814
60MP0002109_abnormal_limb_morphology1.46729716
61MP0000569_abnormal_digit_pigmentation1.45825764
62MP0005508_abnormal_skeleton_morphology1.45662182
63MP0000767_abnormal_smooth_muscle1.44463826
64MP0003045_fibrosis1.43472915
65MP0002148_abnormal_hypersensitivity_rea1.42984682
66MP0001919_abnormal_reproductive_system1.40475070
67MP0003091_abnormal_cell_migration1.38877773
68MP0002113_abnormal_skeleton_development1.38742630
69MP0000163_abnormal_cartilage_morphology1.37676044
70MP0001879_abnormal_lymphatic_vessel1.35458740
71MP0000538_abnormal_urinary_bladder1.35111483
72MP0002132_abnormal_respiratory_system1.35106639
73MP0008004_abnormal_stomach_pH1.33270329
74MP0002282_abnormal_trachea_morphology1.32093495
75MP0000432_abnormal_head_morphology1.31086085
76MP0003303_peritoneal_inflammation1.30985502
77MP0005248_abnormal_Harderian_gland1.30654659
78MP0005595_abnormal_vascular_smooth1.30283968
79MP0001533_abnormal_skeleton_physiology1.29114845
80MP0001849_ear_inflammation1.26773959
81MP0005076_abnormal_cell_differentiation1.26472339
82MP0003724_increased_susceptibility_to1.25450472
83MP0002295_abnormal_pulmonary_circulatio1.24940656
84MP0002116_abnormal_craniofacial_bone1.24867301
85MP0009785_altered_susceptibility_to1.24070198
86MP0009703_decreased_birth_body1.23601770
87MP0003950_abnormal_plasma_membrane1.20475792
88MP0002896_abnormal_bone_mineralization1.18755415
89MP0003448_altered_tumor_morphology1.18401261
90MP0005410_abnormal_fertilization1.17267965
91MP0005551_abnormal_eye_electrophysiolog1.16879228
92MP0005365_abnormal_bile_salt1.15963986
93MP0002127_abnormal_cardiovascular_syste1.15789446
94MP0002419_abnormal_innate_immunity1.14204546
95MP0002177_abnormal_outer_ear1.13423895
96MP0009764_decreased_sensitivity_to1.12923494
97MP0002108_abnormal_muscle_morphology1.12032678
98MP0005389_reproductive_system_phenotype1.09732488
99MP0003115_abnormal_respiratory_system1.08217595
100MP0001299_abnormal_eye_distance/1.08188463
101MP0003690_abnormal_glial_cell1.06512892
102MP0002396_abnormal_hematopoietic_system1.02945070
103MP0005397_hematopoietic_system_phenotyp1.01008554
104MP0001545_abnormal_hematopoietic_system1.01008554
105MP0003828_pulmonary_edema0.99818211
106MP0000613_abnormal_salivary_gland0.99653763
107MP0001727_abnormal_embryo_implantation0.98663630
108MP0004883_abnormal_blood_vessel0.98247851
109MP0003075_altered_response_to0.97711720
110MP0001340_abnormal_eyelid_morphology0.97090256
111MP0003938_abnormal_ear_development0.97036118
112MP0000604_amyloidosis0.92682892
113MP0009278_abnormal_bone_marrow0.91648429
114MP0005165_increased_susceptibility_to0.91091648
115MP0003436_decreased_susceptibility_to0.91066442
116MP0002332_abnormal_exercise_endurance0.90879099
117MP0004145_abnormal_muscle_electrophysio0.90329291
118MP0005391_vision/eye_phenotype0.89954178
119MP0002092_abnormal_eye_morphology0.89442699
120MP0005253_abnormal_eye_physiology0.89373991
121MP0002133_abnormal_respiratory_system0.88638295
122MP0005388_respiratory_system_phenotype0.88638295
123MP0001175_abnormal_lung_morphology0.88438985
124MP0005367_renal/urinary_system_phenotyp0.85428033
125MP0000516_abnormal_urinary_system0.85428033
126MP0001324_abnormal_eye_pigmentation0.84079931
127MP0009697_abnormal_copulation0.83771286
128MP0000465_gastrointestinal_hemorrhage0.82064389
129MP0005164_abnormal_response_to0.81741352
130MP0001501_abnormal_sleep_pattern0.80751565
131MP0005197_abnormal_uvea_morphology0.80654486
132MP0001614_abnormal_blood_vessel0.80214167
133MP0000566_synostosis0.79387052
134MP0002925_abnormal_cardiovascular_devel0.79015947
135MP0002114_abnormal_axial_skeleton0.78900780
136MP0008877_abnormal_DNA_methylation0.77998304
137MP0002111_abnormal_tail_morphology0.77321350
138MP0005390_skeleton_phenotype0.77214620
139MP0005000_abnormal_immune_tolerance0.77039885
140MP0003566_abnormal_cell_adhesion0.77023901
141MP0003453_abnormal_keratinocyte_physiol0.76603272
142MP0000858_altered_metastatic_potential0.76521889
143MP0000750_abnormal_muscle_regeneration0.76233869
144MP0002128_abnormal_blood_circulation0.74663172
145MP0003567_abnormal_fetal_cardiomyocyte0.74216647
146MP0009672_abnormal_birth_weight0.74215545
147MP0005671_abnormal_response_to0.74174463
148MP0002998_abnormal_bone_remodeling0.73176181
149MP0003795_abnormal_bone_structure0.72006818
150MP0001286_abnormal_eye_development0.70297683
151MP0000681_abnormal_thyroid_gland0.70179339
152MP0005647_abnormal_sex_gland0.69931799
153MP0002405_respiratory_system_inflammati0.69894087
154MP0005195_abnormal_posterior_eye0.69838384
155MP0003119_abnormal_digestive_system0.69520285
156MP0005360_urolithiasis0.69481189
157MP0001845_abnormal_inflammatory_respons0.69363472
158MP0004134_abnormal_chest_morphology0.68922401
159MP0008469_abnormal_protein_level0.65436112
160MP0002085_abnormal_embryonic_tissue0.65212704
161MP0003806_abnormal_nucleotide_metabolis0.63846468
162MP0004197_abnormal_fetal_growth/weight/0.63608745
163MP0000678_abnormal_parathyroid_gland0.63312661
164MP0000266_abnormal_heart_morphology0.61386144
165MP0000920_abnormal_myelination0.60759155
166MP0001764_abnormal_homeostasis0.60636465
167MP0003936_abnormal_reproductive_system0.60595677
168MP0009763_increased_sensitivity_to0.59895956
169MP0010155_abnormal_intestine_physiology0.59423928
170MP0004484_altered_response_of0.59251460
171MP0002277_abnormal_respiratory_mucosa0.57756387

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.87396894
2Testicular neoplasm (HP:0010788)8.80028954
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)7.39164723
4Short 4th metacarpal (HP:0010044)7.39164723
5Hypoplastic left heart (HP:0004383)7.07612516
6Mesangial abnormality (HP:0001966)6.77157251
7Anomalous pulmonary venous return (HP:0010772)6.44757038
8Abnormal sex determination (HP:0012244)6.27871342
9Sex reversal (HP:0012245)6.27871342
10Abnormality of the pulmonary veins (HP:0011718)5.89701395
11Abnormality of the 4th metacarpal (HP:0010012)5.89192532
12Hypoplastic heart (HP:0001961)5.69556144
13Germ cell neoplasia (HP:0100728)5.06345616
14Microglossia (HP:0000171)4.94015598
15Transposition of the great arteries (HP:0001669)4.60608034
16Abnormal connection of the cardiac segments (HP:0011545)4.60608034
17Abnormal ventriculo-arterial connection (HP:0011563)4.60608034
18Abnormality of glycolipid metabolism (HP:0010969)4.40618064
19Abnormality of liposaccharide metabolism (HP:0010968)4.40618064
20Abnormality of glycosphingolipid metabolism (HP:0004343)4.40618064
21Upper motor neuron abnormality (HP:0002127)4.27016938
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.25198117
23Degeneration of the lateral corticospinal tracts (HP:0002314)4.25198117
24Vitreoretinal degeneration (HP:0000655)4.17702356
25Chorioretinal atrophy (HP:0000533)3.72277191
26Shallow orbits (HP:0000586)3.70366481
27Congenital stationary night blindness (HP:0007642)3.56971605
28Male pseudohermaphroditism (HP:0000037)3.48650927
29Systemic lupus erythematosus (HP:0002725)3.41130862
30Vertebral compression fractures (HP:0002953)3.38539115
31Protrusio acetabuli (HP:0003179)3.27178898
32Dysostosis multiplex (HP:0000943)3.22650939
33Vacuolated lymphocytes (HP:0001922)3.19622087
34Female pseudohermaphroditism (HP:0010458)3.14031548
35Primary adrenal insufficiency (HP:0008207)3.12463816
36Abnormality of the parietal bone (HP:0002696)3.10745680
37Lymphangioma (HP:0100764)3.09047901
38Mediastinal lymphadenopathy (HP:0100721)3.07547850
39Short middle phalanx of the 5th finger (HP:0004220)3.07052575
40Hepatoblastoma (HP:0002884)3.05516844
41Abnormality of the corticospinal tract (HP:0002492)3.04693637
42True hermaphroditism (HP:0010459)3.02537131
43Mesomelia (HP:0003027)2.93224727
44Midline defect of the nose (HP:0004122)2.91799614
45Spondylolisthesis (HP:0003302)2.87966412
46Renal duplication (HP:0000075)2.84191924
47Abnormality of the phalanges of the hallux (HP:0010057)2.78915756
48Abnormality of the lower motor neuron (HP:0002366)2.78819490
49Broad toe (HP:0001837)2.77869189
50Shoulder girdle muscle weakness (HP:0003547)2.77230545
51Anteriorly placed anus (HP:0001545)2.74309912
52Male infertility (HP:0003251)2.71537893
53Disinhibition (HP:0000734)2.70545268
54Cutaneous finger syndactyly (HP:0010554)2.70389793
55Asymmetry of the thorax (HP:0001555)2.70143777
56Wide anterior fontanel (HP:0000260)2.67521366
57Abnormality of the peritoneum (HP:0002585)2.66212887
58Periauricular skin pits (HP:0100277)2.64149217
59Preauricular pit (HP:0004467)2.64149217
60Urinary bladder sphincter dysfunction (HP:0002839)2.63652258
61Syringomyelia (HP:0003396)2.62830737
62Spinal cord lesions (HP:0100561)2.62830737
63Beaking of vertebral bodies (HP:0004568)2.58893556
64Amyotrophic lateral sclerosis (HP:0007354)2.57688217
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56219986
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56219986
67Abnormality of polysaccharide metabolism (HP:0011012)2.56219986
68Wide cranial sutures (HP:0010537)2.55363930
69Abnormal lung lobation (HP:0002101)2.55232375
70Turricephaly (HP:0000262)2.52281052
71Premature rupture of membranes (HP:0001788)2.51857699
72Pigmentary retinal degeneration (HP:0001146)2.50731877
73Impaired vibration sensation in the lower limbs (HP:0002166)2.50175984
74Mucopolysacchariduria (HP:0008155)2.47551942
75Urinary glycosaminoglycan excretion (HP:0003541)2.47551942
76Loss of speech (HP:0002371)2.43928385
77Broad metatarsal (HP:0001783)2.42280742
78Ovarian neoplasm (HP:0100615)2.40642892
79Mitral valve prolapse (HP:0001634)2.40070627
80Nuclear cataract (HP:0100018)2.39747978
81Oligodontia (HP:0000677)2.37654730
82Focal segmental glomerulosclerosis (HP:0000097)2.36837939
83Aortic dissection (HP:0002647)2.36798472
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.33816167
85Short clavicles (HP:0000894)2.33611532
86Coronal craniosynostosis (HP:0004440)2.32150936
87Narrow palate (HP:0000189)2.31716185
88Abnormality of the 2nd finger (HP:0004100)2.31133031
89Glomerulonephritis (HP:0000099)2.30373871
90Rimmed vacuoles (HP:0003805)2.29576295
91Deviation of the hallux (HP:0010051)2.28372787
92Abnormality of the nasolacrimal system (HP:0000614)2.28067258
93Cutaneous syndactyly (HP:0012725)2.23236354
94Broad thumb (HP:0011304)2.23023107
95Neurofibrillary tangles (HP:0002185)2.21068972
96Increased cerebral lipofuscin (HP:0011813)2.20914450
97Hypoplasia of the maxilla (HP:0000327)2.18326086
98Nephroblastoma (Wilms tumor) (HP:0002667)2.17371643
99Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.16551384
100Short 5th finger (HP:0009237)2.16449665
101Trigonocephaly (HP:0000243)2.15678975
102Abnormality of male internal genitalia (HP:0000022)2.15565683
103Complement deficiency (HP:0004431)2.14666079
104Aplasia/Hypoplasia of the clavicles (HP:0006710)2.13611795
105Disproportionate tall stature (HP:0001519)2.12816651
106Supernumerary ribs (HP:0005815)2.12133253
107Biconcave vertebral bodies (HP:0004586)2.12043808
108Increased number of teeth (HP:0011069)2.11523884
109Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11354976
110Hallux valgus (HP:0001822)2.10240327
111Diastasis recti (HP:0001540)2.09667105
112Broad hallux (HP:0010055)2.09268010
113Embryonal renal neoplasm (HP:0011794)2.07274993
114Broad ribs (HP:0000885)2.05162699
115Hypoplasia of the uterus (HP:0000013)2.03041130
116Dyschromatopsia (HP:0007641)2.02660750
117Aortic aneurysm (HP:0004942)2.00700141
118Nausea (HP:0002018)2.00675306
119Bulbar palsy (HP:0001283)1.99447450
120Short metatarsal (HP:0010743)1.98651579
121Abnormality of the humeroradial joint (HP:0100744)1.98585845
122Buphthalmos (HP:0000557)1.97947755
123Urinary urgency (HP:0000012)1.97401167
124Synostosis involving the elbow (HP:0003938)1.96821563
125Humeroradial synostosis (HP:0003041)1.96821563
126Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.95526039
127Atresia of the external auditory canal (HP:0000413)1.94975984
128Glomerulosclerosis (HP:0000096)1.92311653
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.91048870
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.90690626
131Hematochezia (HP:0002573)1.90641906
132Abnormality of the phalanges of the 5th finger (HP:0004213)1.90317628
133Abnormality of dentin (HP:0010299)1.89943957
134Knee flexion contracture (HP:0006380)1.88702290
135Preaxial foot polydactyly (HP:0001841)1.86857975
136Broad long bones (HP:0005622)1.85319997
137Limited hip movement (HP:0008800)1.85248041
138Dilatation of the ascending aorta (HP:0005111)1.85053652
139Delayed cranial suture closure (HP:0000270)1.84787228
140Dislocated radial head (HP:0003083)1.83680186
141Abnormality of the vocal cords (HP:0008777)1.83638026
142Soft skin (HP:0000977)1.82818457
143Broad phalanges of the hand (HP:0009768)1.81759791
144Complete atrioventricular canal defect (HP:0001674)1.80761258
145Broad finger (HP:0001500)1.80708212
146Abnormality of the radial head (HP:0003995)1.80511513
147Abnormal ossification of hand bones (HP:0005921)1.80327333
148Flat face (HP:0012368)1.79970410
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79898107
150Nasolacrimal duct obstruction (HP:0000579)1.79632070
151Papilledema (HP:0001085)1.79386072
152Long eyelashes (HP:0000527)1.78895781
153Increased nuchal translucency (HP:0010880)1.78466017
154Limited elbow extension (HP:0001377)1.78422433
155Osteolytic defects of the hand bones (HP:0009699)1.78212147
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.78212147
157Pathologic fracture (HP:0002756)1.77736312
158Bladder diverticulum (HP:0000015)1.77658891
159Abnormality of secondary sexual hair (HP:0009888)1.77602072
160Abnormality of the axillary hair (HP:0100134)1.77602072
161Broad phalanx (HP:0006009)1.77195176
162Agnosia (HP:0010524)1.76975583
163Spontaneous hematomas (HP:0007420)1.75830611
164Chin dimple (HP:0010751)1.75083955
165Supernumerary bones of the axial skeleton (HP:0009144)1.74868275
166Increased corneal curvature (HP:0100692)1.74749224
167Keratoconus (HP:0000563)1.74749224
168Congenital sensorineural hearing impairment (HP:0008527)1.74587528
169Spastic paraplegia (HP:0001258)1.73336341
170Vascular tortuosity (HP:0004948)1.72460955
171Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72301543
172Abnormality of macrophages (HP:0004311)1.72289479
173Blue sclerae (HP:0000592)1.69805812
174Peritonitis (HP:0002586)1.69436992
175Cerebral aneurysm (HP:0004944)1.69150577
176Hypoplastic labia majora (HP:0000059)1.68848894
177Asymmetric septal hypertrophy (HP:0001670)1.68472663
178Chronic hepatic failure (HP:0100626)1.68028599
179Camptodactyly of toe (HP:0001836)1.66985433
180Malnutrition (HP:0004395)1.66629605
181Urethral obstruction (HP:0000796)1.66294785
182Arterial tortuosity (HP:0005116)1.64808737
183Thin bony cortex (HP:0002753)1.64699622
184Abnormality of the vasculature of the conjunctiva (HP:0008054)1.64458190
185Skin pits (HP:0100276)1.63688575
186Osteomalacia (HP:0002749)1.62491193
187Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61651644
188Paraplegia (HP:0010550)1.61174497
189Atrioventricular canal defect (HP:0006695)1.58479142
190Abnormality of complement system (HP:0005339)1.58404932
191Neonatal short-limb short stature (HP:0008921)1.56403565
192Increased neuronal autofluorescent lipopigment (HP:0002074)1.55230649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA37.55379649
2LATS13.12901008
3MUSK3.10090596
4CDK42.99819828
5NLK2.90539121
6GRK72.71625118
7EPHB12.67867490
8PDGFRA2.66688563
9DDR22.54446646
10IRAK32.52795216
11FGR2.40932128
12MAP3K102.33595103
13CAMK1D2.30813842
14CAMK1G2.25282300
15SIK12.03594033
16NME22.02422387
17EPHB22.02316374
18MAP3K11.97066900
19NEK91.95280057
20TGFBR21.93188483
21PTK61.91328770
22SGK21.89674386
23PKN21.85706383
24RPS6KA41.82116928
25CDK121.78587636
26ERBB31.77381021
27SGK2231.63140153
28SGK4941.63140153
29RIPK11.61875568
30KIT1.55588837
31MKNK11.55291012
32TRIB31.51069019
33TNK21.47984098
34ERN11.46154009
35PLK41.44918520
36TTN1.43529636
37PBK1.43346734
38MATK1.42234672
39ACVR1B1.41960779
40MAP3K141.40131192
41MYLK1.39734675
42SCYL21.37121951
43TGFBR11.35555254
44IKBKE1.34560065
45PINK11.34027587
46RPS6KC11.33454605
47RPS6KL11.33454605
48RPS6KA21.33336356
49TBK11.33250616
50FGFR11.30709872
51CDK191.30675755
52PDGFRB1.30052314
53DMPK1.20538498
54WNK11.16566466
55FGFR21.14166251
56RPS6KA61.12748538
57MOS1.06993927
58BLK1.06176954
59STK31.05212359
60PRKCH1.04553694
61ERBB21.03295751
62NEK21.02164997
63CSNK1A1L1.02046242
64GRK11.01444895
65PRPF4B0.99339680
66CSNK1G10.98256417
67MKNK20.96126818
68LRRK20.93448893
69CSF1R0.93022330
70JAK30.92578050
71FRK0.91818130
72IKBKB0.91781852
73LATS20.90246778
74ABL20.88995803
75FGFR30.86088659
76BMPR20.85767781
77MAP4K10.83815330
78DYRK1A0.82558051
79CDC42BPA0.81246079
80PIM20.81236881
81ADRBK20.80116828
82MAP3K60.78946142
83BRD40.77567096
84CDK60.77152450
85MTOR0.75969679
86MAP3K30.72182279
87TYRO30.71039282
88MAP3K50.70019195
89NUAK10.69318195
90JAK10.68592583
91TAOK20.66909254
92STK240.66021345
93ADRBK10.63885513
94KDR0.63716086
95PAK20.63424919
96RIPK40.63182266
97CDK90.62996958
98IGF1R0.61404321
99PAK10.61201713
100SGK10.61051688
101TIE10.59931043
102CAMK40.59723935
103TYK20.59639528
104PAK40.58452145
105ICK0.58331441
106IRAK40.58122972
107MARK30.57709077
108ROCK10.55554330
109BMX0.54834260
110CSNK1G30.54555057
111CLK10.53906306
112PRKAA20.51547566
113FGFR40.49818924
114FYN0.49580977
115CSNK1D0.48967526
116STK40.47361512
117PTK20.47226305
118PIM10.46115968
119INSR0.44505179
120DYRK1B0.43960838
121MAPK10.43922099
122MARK20.43176894
123PLK20.42691380
124LYN0.42477918
125MAP2K30.42352990
126CSNK1G20.41484878
127EGFR0.41445814
128PRKACG0.41075380
129MINK10.40662835
130MAPK40.40148723
131FLT30.39534723
132RPS6KA10.39131543
133SGK30.38247778
134ZAP700.37685950
135AKT10.37323001
136GSK3A0.37273185
137HCK0.36753347
138CSK0.36598432
139PRKG20.35099937
140CDK70.35077892
141MAP2K20.34965570
142MAPK70.34656213
143TNIK0.33127010
144WNK30.33043319
145CDC70.32901179
146MAPK120.32095993
147INSRR0.31925603
148ABL10.31765173
149SRC0.31476833
150PRKACA0.31165483
151MAPK30.30227380
152AKT30.28531100
153FES0.28200184
154PRKD10.28014033
155MAPK140.27987752
156SIK20.27978275
157CHUK0.27930190
158MAP3K130.27866699
159STK100.27458052

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.30872155
2Other glycan degradation_Homo sapiens_hsa005113.91385208
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.86768157
4Basal cell carcinoma_Homo sapiens_hsa052172.41877196
5Renin-angiotensin system_Homo sapiens_hsa046142.38511273
6Rheumatoid arthritis_Homo sapiens_hsa053232.29934168
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.00509846
8Staphylococcus aureus infection_Homo sapiens_hsa051501.98235231
9Complement and coagulation cascades_Homo sapiens_hsa046101.91748082
10Nitrogen metabolism_Homo sapiens_hsa009101.91270841
11Hedgehog signaling pathway_Homo sapiens_hsa043401.87107325
12B cell receptor signaling pathway_Homo sapiens_hsa046621.85210942
13Sulfur metabolism_Homo sapiens_hsa009201.80674716
14Proteoglycans in cancer_Homo sapiens_hsa052051.79318123
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.77782715
16Lysine degradation_Homo sapiens_hsa003101.66639328
17ECM-receptor interaction_Homo sapiens_hsa045121.61384209
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58867349
19Prion diseases_Homo sapiens_hsa050201.53868588
20Leishmaniasis_Homo sapiens_hsa051401.52480189
21Tuberculosis_Homo sapiens_hsa051521.48754996
22Malaria_Homo sapiens_hsa051441.48537825
23Adherens junction_Homo sapiens_hsa045201.46332755
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44661874
25Ovarian steroidogenesis_Homo sapiens_hsa049131.34884046
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33473290
27Mineral absorption_Homo sapiens_hsa049781.32367902
28MicroRNAs in cancer_Homo sapiens_hsa052061.31577587
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30857423
30Protein digestion and absorption_Homo sapiens_hsa049741.30543491
31Focal adhesion_Homo sapiens_hsa045101.29608593
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28884728
33Axon guidance_Homo sapiens_hsa043601.28033321
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26495309
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25932433
36Hippo signaling pathway_Homo sapiens_hsa043901.23848781
37Prostate cancer_Homo sapiens_hsa052151.22435640
38Asthma_Homo sapiens_hsa053101.20784294
39Lysosome_Homo sapiens_hsa041421.19942149
40Wnt signaling pathway_Homo sapiens_hsa043101.19521984
41TGF-beta signaling pathway_Homo sapiens_hsa043501.18641053
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18121111
43Chemical carcinogenesis_Homo sapiens_hsa052041.16845033
44Dorso-ventral axis formation_Homo sapiens_hsa043201.16103044
45Osteoclast differentiation_Homo sapiens_hsa043801.15748135
46Amoebiasis_Homo sapiens_hsa051461.15735860
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.13843318
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13588382
49Caffeine metabolism_Homo sapiens_hsa002321.12674853
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11718951
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11606817
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10505938
53PPAR signaling pathway_Homo sapiens_hsa033201.10107270
54Sphingolipid metabolism_Homo sapiens_hsa006001.08615258
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07929128
56Insulin resistance_Homo sapiens_hsa049311.05832146
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05327319
58Phagosome_Homo sapiens_hsa041451.05137745
59Glutathione metabolism_Homo sapiens_hsa004801.04144882
60Viral myocarditis_Homo sapiens_hsa054161.01634737
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.01501843
62African trypanosomiasis_Homo sapiens_hsa051431.00459637
63Salmonella infection_Homo sapiens_hsa051320.99883361
64Tryptophan metabolism_Homo sapiens_hsa003800.96990048
65Galactose metabolism_Homo sapiens_hsa000520.95049145
66Chronic myeloid leukemia_Homo sapiens_hsa052200.94361182
67Platelet activation_Homo sapiens_hsa046110.92577067
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92518787
69Pathways in cancer_Homo sapiens_hsa052000.92352759
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92316506
71Antigen processing and presentation_Homo sapiens_hsa046120.90941591
72HTLV-I infection_Homo sapiens_hsa051660.87799746
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86764661
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.85404913
75Small cell lung cancer_Homo sapiens_hsa052220.82771732
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.81126137
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80555829
78Arginine biosynthesis_Homo sapiens_hsa002200.78304046
79Renin secretion_Homo sapiens_hsa049240.77406088
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74563735
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73859234
82Chemokine signaling pathway_Homo sapiens_hsa040620.73295779
83Pancreatic cancer_Homo sapiens_hsa052120.72604506
84Fatty acid elongation_Homo sapiens_hsa000620.69271658
85Viral carcinogenesis_Homo sapiens_hsa052030.68901426
86Colorectal cancer_Homo sapiens_hsa052100.68131479
87Glioma_Homo sapiens_hsa052140.67878228
88Steroid biosynthesis_Homo sapiens_hsa001000.67667364
89Prolactin signaling pathway_Homo sapiens_hsa049170.67316922
90Retinol metabolism_Homo sapiens_hsa008300.66367749
91Melanogenesis_Homo sapiens_hsa049160.66345303
92Hepatitis B_Homo sapiens_hsa051610.65948272
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65778542
94Fatty acid degradation_Homo sapiens_hsa000710.65525189
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65069606
96Melanoma_Homo sapiens_hsa052180.64446634
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63744782
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62699052
99Allograft rejection_Homo sapiens_hsa053300.61978135
100Toxoplasmosis_Homo sapiens_hsa051450.60994254
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58852505
102Hepatitis C_Homo sapiens_hsa051600.58397612
103Cell cycle_Homo sapiens_hsa041100.57793936
104Renal cell carcinoma_Homo sapiens_hsa052110.56439110
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56173387
106MAPK signaling pathway_Homo sapiens_hsa040100.55454841
107Rap1 signaling pathway_Homo sapiens_hsa040150.55417174
108Pertussis_Homo sapiens_hsa051330.55378811
109N-Glycan biosynthesis_Homo sapiens_hsa005100.54553979
110Herpes simplex infection_Homo sapiens_hsa051680.54410182
111Thyroid cancer_Homo sapiens_hsa052160.52305564
112mTOR signaling pathway_Homo sapiens_hsa041500.51937651
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51716396
114Hematopoietic cell lineage_Homo sapiens_hsa046400.51272316
115Notch signaling pathway_Homo sapiens_hsa043300.50628053
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.50144442
117Dilated cardiomyopathy_Homo sapiens_hsa054140.48563797
118Type II diabetes mellitus_Homo sapiens_hsa049300.47861312
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46492775
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.46373765
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45955444
122Apoptosis_Homo sapiens_hsa042100.44572888
123Endometrial cancer_Homo sapiens_hsa052130.43786311
124Legionellosis_Homo sapiens_hsa051340.43259646
125FoxO signaling pathway_Homo sapiens_hsa040680.43082866
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.42891540
127Influenza A_Homo sapiens_hsa051640.42232942
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41947245
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41703067
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41468816
131TNF signaling pathway_Homo sapiens_hsa046680.41282212
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41151599
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39254519
134Graft-versus-host disease_Homo sapiens_hsa053320.39070642
135T cell receptor signaling pathway_Homo sapiens_hsa046600.38700296
136Non-small cell lung cancer_Homo sapiens_hsa052230.38637231
137GnRH signaling pathway_Homo sapiens_hsa049120.38252090
138Endocytosis_Homo sapiens_hsa041440.38122033
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.38054460
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37451376
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36920709
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.36065994
143ABC transporters_Homo sapiens_hsa020100.35756914
144Histidine metabolism_Homo sapiens_hsa003400.33056196
145Bladder cancer_Homo sapiens_hsa052190.32359822
146Pentose phosphate pathway_Homo sapiens_hsa000300.28132180
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.27067274
148Salivary secretion_Homo sapiens_hsa049700.25766642
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25228180

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