TMEM260

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.48580013
2pyrimidine nucleobase catabolic process (GO:0006208)4.70769080
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67574012
4L-phenylalanine catabolic process (GO:0006559)4.67574012
5tachykinin receptor signaling pathway (GO:0007217)4.56820270
6neural tube formation (GO:0001841)4.43648048
7alpha-linolenic acid metabolic process (GO:0036109)4.27194052
8establishment of protein localization to Golgi (GO:0072600)4.22442314
9L-phenylalanine metabolic process (GO:0006558)4.18054920
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.18054920
11protein targeting to Golgi (GO:0000042)4.04191377
12nucleobase catabolic process (GO:0046113)4.01370194
13aromatic amino acid family catabolic process (GO:0009074)4.00584260
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91063080
15dentate gyrus development (GO:0021542)3.89269968
16protein carboxylation (GO:0018214)3.87415712
17peptidyl-glutamic acid carboxylation (GO:0017187)3.87415712
18protein polyglutamylation (GO:0018095)3.79707873
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70017209
20tyrosine metabolic process (GO:0006570)3.67125718
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65698418
22complement activation, alternative pathway (GO:0006957)3.64419457
23epithelial cilium movement (GO:0003351)3.61333894
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60474452
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60474452
26retrograde transport, vesicle recycling within Golgi (GO:0000301)3.60286316
27bile acid biosynthetic process (GO:0006699)3.59949180
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53079172
29positive regulation of neurological system process (GO:0031646)3.53072396
30regulation of bile acid biosynthetic process (GO:0070857)3.50916274
31ethanol oxidation (GO:0006069)3.50216322
32regulation of cilium movement (GO:0003352)3.43943782
33regulation of protein activation cascade (GO:2000257)3.40492613
34intraciliary transport (GO:0042073)3.40432160
35head development (GO:0060322)3.35461694
36tryptophan catabolic process (GO:0006569)3.34158564
37indole-containing compound catabolic process (GO:0042436)3.34158564
38indolalkylamine catabolic process (GO:0046218)3.34158564
39cerebral cortex radially oriented cell migration (GO:0021799)3.34002266
40regulation of complement activation (GO:0030449)3.27250416
41tryptophan metabolic process (GO:0006568)3.25048140
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.23504211
43urea cycle (GO:0000050)3.23038574
44urea metabolic process (GO:0019627)3.23038574
45valine metabolic process (GO:0006573)3.22507705
46olfactory bulb development (GO:0021772)3.20440342
47high-density lipoprotein particle remodeling (GO:0034375)3.16836481
48axoneme assembly (GO:0035082)3.16636523
49cilium movement (GO:0003341)3.15830470
50acrosome reaction (GO:0007340)3.14788446
51negative regulation of neurological system process (GO:0031645)3.14723010
52antigen processing and presentation of endogenous antigen (GO:0019883)3.14656588
53phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.14174920
54regulation of sarcomere organization (GO:0060297)3.13023966
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11665607
56regulation of fibrinolysis (GO:0051917)3.07231968
57bile acid metabolic process (GO:0008206)3.05794290
58presynaptic membrane assembly (GO:0097105)3.04799029
59tyrosine phosphorylation of STAT protein (GO:0007260)3.04665446
60presynaptic membrane organization (GO:0097090)3.04428780
61histone H3-K4 trimethylation (GO:0080182)3.04330196
62reverse cholesterol transport (GO:0043691)3.02857551
63positive regulation of gamma-delta T cell activation (GO:0046645)3.02165633
64negative regulation of fibrinolysis (GO:0051918)3.01773007
65cilium organization (GO:0044782)3.01739619
66cilium assembly (GO:0042384)3.01261231
67protein localization to Golgi apparatus (GO:0034067)3.00377128
68nitrogen cycle metabolic process (GO:0071941)2.99277009
69Golgi to endosome transport (GO:0006895)2.98452556
70cilium morphogenesis (GO:0060271)2.98068371
71antigen processing and presentation via MHC class Ib (GO:0002475)2.96057200
72embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95691969
73drug transmembrane transport (GO:0006855)2.95319174
74histone mRNA catabolic process (GO:0071044)2.93544531
75glyoxylate metabolic process (GO:0046487)2.93280422
76plasma lipoprotein particle assembly (GO:0034377)2.92481244
77kynurenine metabolic process (GO:0070189)2.90961535
78blood coagulation, intrinsic pathway (GO:0007597)2.90769103
79cellular response to ethanol (GO:0071361)2.89501493
80sulfur amino acid catabolic process (GO:0000098)2.88761067
81protein K11-linked deubiquitination (GO:0035871)2.88377912
82cysteine metabolic process (GO:0006534)2.86661045
83positive regulation of respiratory burst (GO:0060267)2.86649417
84definitive hemopoiesis (GO:0060216)2.86285503
85acrosome assembly (GO:0001675)2.86025151
86macroautophagy (GO:0016236)2.84902325
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83503742
88opsonization (GO:0008228)2.80814660
89regulation of transmission of nerve impulse (GO:0051969)2.78743265
90aromatic amino acid family metabolic process (GO:0009072)2.78717105
91protein targeting to vacuole (GO:0006623)2.77997962
92protein targeting to lysosome (GO:0006622)2.77997962
93establishment of protein localization to vacuole (GO:0072666)2.77997962
94negative regulation of cAMP-mediated signaling (GO:0043951)2.77267850
95phospholipid efflux (GO:0033700)2.76176834
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74841551
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.74841551
98regulation of translation, ncRNA-mediated (GO:0045974)2.74841551
99regulation of cholesterol biosynthetic process (GO:0045540)2.73850376
100prenylation (GO:0097354)2.72938279
101protein prenylation (GO:0018342)2.72938279
102protein-lipid complex assembly (GO:0065005)2.72025545
103protein-lipid complex remodeling (GO:0034368)2.71983473
104macromolecular complex remodeling (GO:0034367)2.71983473
105plasma lipoprotein particle remodeling (GO:0034369)2.71983473
106intra-Golgi vesicle-mediated transport (GO:0006891)2.71583820
107calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70894762
108protein localization to cilium (GO:0061512)2.70161288
109plasma lipoprotein particle clearance (GO:0034381)2.70014821
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68558644
111amino-acid betaine metabolic process (GO:0006577)2.67414877
112positive regulation of granulocyte differentiation (GO:0030854)2.67360751
113cholesterol efflux (GO:0033344)2.67086882
114phospholipid homeostasis (GO:0055091)2.66886654
115cell wall macromolecule catabolic process (GO:0016998)2.66469359
116regulation of cholesterol esterification (GO:0010872)2.66120711
117phosphatidylethanolamine metabolic process (GO:0046337)2.65226469
118positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.64960748
119mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.64960748
120positive regulation of glycolytic process (GO:0045821)2.64840599
121triglyceride homeostasis (GO:0070328)2.64646760
122acylglycerol homeostasis (GO:0055090)2.64646760
123forebrain neuron differentiation (GO:0021879)2.63574227
124behavioral response to ethanol (GO:0048149)2.63333904
125photoreceptor cell maintenance (GO:0045494)2.63317130
126polyol catabolic process (GO:0046174)2.62856202
127very long-chain fatty acid metabolic process (GO:0000038)2.62394302
128dicarboxylic acid biosynthetic process (GO:0043650)2.61537582
129regulation of triglyceride catabolic process (GO:0010896)2.61135245
130cellular component assembly involved in morphogenesis (GO:0010927)2.60769546
131negative regulation of lipase activity (GO:0060192)2.60323372
132snRNA transcription (GO:0009301)2.60175528
133protein activation cascade (GO:0072376)2.59985342
134bile acid and bile salt transport (GO:0015721)2.58522849
135cerebral cortex cell migration (GO:0021795)2.58192044
136myelin assembly (GO:0032288)2.58169689
137positive regulation of mitochondrial fission (GO:0090141)2.57440396
138very-low-density lipoprotein particle assembly (GO:0034379)2.57351656
139regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.57244308
140regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57244308
141ethanol metabolic process (GO:0006067)2.57012605
142substrate-independent telencephalic tangential migration (GO:0021826)2.55979713
143substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.55979713
144cellular glucuronidation (GO:0052695)2.55619649
145negative regulation of cholesterol transport (GO:0032375)2.55501826
146negative regulation of sterol transport (GO:0032372)2.55501826
147regulation of memory T cell differentiation (GO:0043380)2.55428421
148positive regulation of oligodendrocyte differentiation (GO:0048714)2.55308444
149monoubiquitinated protein deubiquitination (GO:0035520)2.54073862
150phosphatidylethanolamine biosynthetic process (GO:0006646)2.53984368
151regulation of female gonad development (GO:2000194)2.53181622
152somite rostral/caudal axis specification (GO:0032525)2.52565888
153regulation of cholesterol metabolic process (GO:0090181)2.52181646
154sperm motility (GO:0030317)2.51699946
155growth hormone receptor signaling pathway (GO:0060396)2.51421239
156central nervous system neuron axonogenesis (GO:0021955)2.50827945
157cilium or flagellum-dependent cell motility (GO:0001539)2.50448909
158inositol phosphate catabolic process (GO:0071545)2.50028580
159ganglion development (GO:0061548)2.49830013
160activated T cell proliferation (GO:0050798)2.49035719
161regulation of humoral immune response (GO:0002920)2.48641214
162plasma lipoprotein particle organization (GO:0071827)2.47570434
163central nervous system projection neuron axonogenesis (GO:0021952)2.46145340
164fibrinolysis (GO:0042730)2.45708653
165cellular response to vitamin D (GO:0071305)2.45681726
166detection of light stimulus involved in sensory perception (GO:0050962)2.45632177
167detection of light stimulus involved in visual perception (GO:0050908)2.45632177
168coenzyme catabolic process (GO:0009109)2.43796089
169single strand break repair (GO:0000012)2.43514293
170regulation of gamma-delta T cell differentiation (GO:0045586)2.42585211
171RNA destabilization (GO:0050779)2.42448344
172cell proliferation in forebrain (GO:0021846)2.41889386
173short-chain fatty acid metabolic process (GO:0046459)2.41076625
174regulation of collateral sprouting (GO:0048670)2.40724002
175positive regulation of lipid catabolic process (GO:0050996)2.40260761
176positive regulation of natural killer cell differentiation (GO:0032825)2.39410466
177complement activation (GO:0006956)2.38961173
178glutamate metabolic process (GO:0006536)2.38953029
179positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.38728868
180complement activation, classical pathway (GO:0006958)2.38643142
181protein-lipid complex subunit organization (GO:0071825)2.38590403
182low-density lipoprotein particle remodeling (GO:0034374)2.37615771
183positive regulation of steroid metabolic process (GO:0045940)2.37443726
184benzene-containing compound metabolic process (GO:0042537)2.37186063
185fatty acid oxidation (GO:0019395)2.37147038
1862-oxoglutarate metabolic process (GO:0006103)2.36154053
187homocysteine metabolic process (GO:0050667)2.34093922
188positive regulation of blood coagulation (GO:0030194)2.33855185
189positive regulation of hemostasis (GO:1900048)2.33855185
190positive regulation of fatty acid beta-oxidation (GO:0032000)2.33283646
191lipid oxidation (GO:0034440)2.33193397
192lipoprotein metabolic process (GO:0042157)2.32869354
193negative regulation of protein activation cascade (GO:2000258)2.32793364
194positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.32388656
195regulation of cholesterol homeostasis (GO:2000188)2.32282589
196indolalkylamine metabolic process (GO:0006586)2.31808949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.46729314
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.11711537
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.57807760
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51313789
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.37191193
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.31328089
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.24031584
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23411681
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17640606
10GATA1_22025678_ChIP-Seq_K562_Human3.15021657
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.05507459
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95572114
13IGF1R_20145208_ChIP-Seq_DFB_Human2.90940351
14GBX2_23144817_ChIP-Seq_PC3_Human2.86961708
15ZNF274_21170338_ChIP-Seq_K562_Hela2.74667417
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57805067
17SCL_19346495_ChIP-Seq_HPC-7_Human2.55887630
18TAF15_26573619_Chip-Seq_HEK293_Human2.33825751
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26762763
20FUS_26573619_Chip-Seq_HEK293_Human2.25877235
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.21590574
22EZH2_22144423_ChIP-Seq_EOC_Human2.18243912
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17711008
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17315039
25RUNX_20019798_ChIP-Seq_JUKART_Human2.16407422
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12748442
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11337480
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08806289
29P300_19829295_ChIP-Seq_ESCs_Human2.08486195
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04076251
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03512305
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.00165302
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98193758
34ER_23166858_ChIP-Seq_MCF-7_Human1.96244816
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90255103
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89717550
37IRF1_19129219_ChIP-ChIP_H3396_Human1.89489194
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87191605
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86641808
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86198792
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84292026
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84292026
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83302503
44SMAD4_21799915_ChIP-Seq_A2780_Human1.83207688
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82638703
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82542246
47EWS_26573619_Chip-Seq_HEK293_Human1.81050430
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78442596
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75827066
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.75159839
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73164922
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.70106687
53CBP_20019798_ChIP-Seq_JUKART_Human1.70008053
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70008053
55STAT3_23295773_ChIP-Seq_U87_Human1.68436164
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68265216
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64183585
58VDR_22108803_ChIP-Seq_LS180_Human1.64090441
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62322743
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60129112
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59366229
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58963437
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55784840
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55603899
65CLOCK_20551151_ChIP-Seq_293T_Human1.55391561
66TCF4_23295773_ChIP-Seq_U87_Human1.54237669
67AR_25329375_ChIP-Seq_VCAP_Human1.53949809
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.53799565
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.53090044
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51575185
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50877515
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49653891
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49478191
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48375192
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.47942245
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.47432406
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46879605
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.45132554
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43724675
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43235652
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42295264
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.41117515
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40715933
84RUNX2_22187159_ChIP-Seq_PCA_Human1.38868324
85GATA1_19941826_ChIP-Seq_K562_Human1.38494299
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36198942
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35550594
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31163511
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.27681580
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26845155
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26719598
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26338170
93P53_22387025_ChIP-Seq_ESCs_Mouse1.25664602
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.25307840
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25088081
96GATA2_19941826_ChIP-Seq_K562_Human1.24067194
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23953643
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23696801
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.22928108
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.22386537
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20395992
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20395992
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20272909
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19298458
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18513284
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18209807
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17583247
108TCF4_22108803_ChIP-Seq_LS180_Human1.17036124
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16538655
110MYB_26560356_Chip-Seq_TH2_Human1.15751114
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15645333
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15644383
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15070620
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.14694053
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14520629
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.13891552
117PU_27001747_Chip-Seq_BMDM_Mouse1.13676902
118VDR_24763502_ChIP-Seq_THP-1_Human1.13654503
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.13559762
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13033635
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.12962905
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12880843
123VDR_24787735_ChIP-Seq_THP-1_Human1.12704213
124P300_18555785_Chip-Seq_ESCs_Mouse1.12573104
125CDX2_22108803_ChIP-Seq_LS180_Human1.12533678
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.11592342
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10416422
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09666065
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.09614609
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09560133
131AHR_22903824_ChIP-Seq_MCF-7_Human1.09458519
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09421618
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09389361
134CBX2_27304074_Chip-Seq_ESCs_Mouse1.09068018
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.08955900
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.07482849
137EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07383603
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06960383
139MYB_26560356_Chip-Seq_TH1_Human1.06644530
140FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06469377
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06236228
142TP53_22573176_ChIP-Seq_HFKS_Human1.06092551
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06053603
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05639011
145SPI1_23127762_ChIP-Seq_K562_Human1.05217623
146GATA3_27048872_Chip-Seq_THYMUS_Human1.05140829
147SOX2_21211035_ChIP-Seq_LN229_Gbm1.04182198
148RNF2_27304074_Chip-Seq_NSC_Mouse1.04078244
149SMAD4_21741376_ChIP-Seq_EPCs_Human1.03766752
150TBL1_22424771_ChIP-Seq_293T_Human1.03212107
151NMYC_18555785_Chip-Seq_ESCs_Mouse1.03151386
152BP1_19119308_ChIP-ChIP_Hs578T_Human1.01681578
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01086393
154AR_21572438_ChIP-Seq_LNCaP_Human1.00924362
155TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00835976
156JUN_21703547_ChIP-Seq_K562_Human1.00353228
157TCF7_22412390_ChIP-Seq_EML_Mouse0.99715421
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99621964
159KDM2B_26808549_Chip-Seq_REH_Human0.99581608
160SOX2_18555785_Chip-Seq_ESCs_Mouse0.98630361
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98485503
162TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97466146
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.97412059
164STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96675757
165FOXA1_25552417_ChIP-Seq_VCAP_Human0.96339590
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94424589
167LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94223198
168SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93240694
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93211309
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93171604
171GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90560489
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89871437
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88698049
174BCAT_22108803_ChIP-Seq_LS180_Human0.88439077
175ESR1_20079471_ChIP-ChIP_T-47D_Human0.88057706
176NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85148331
177TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84884546
178SOX2_20726797_ChIP-Seq_SW620_Human0.82260477
179KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81498047
180CJUN_26792858_Chip-Seq_BT549_Human0.81200620
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80526847
182SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80418474
183MAF_26560356_Chip-Seq_TH1_Human0.80036635
184UTX_26944678_Chip-Seq_JUKART_Human0.79844756
185FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79086767
186E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78416897
187TP63_23658742_ChIP-Seq_EP156T_Human0.78416756
188PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78181307
189MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77104067
190PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76545186
191ESR2_21235772_ChIP-Seq_MCF-7_Human0.75932373
192RUNX1_22412390_ChIP-Seq_EML_Mouse0.75800557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.78604793
2MP0005360_urolithiasis4.37963689
3MP0003787_abnormal_imprinting4.22921718
4MP0005365_abnormal_bile_salt4.04237057
5MP0005085_abnormal_gallbladder_physiolo3.91978525
6MP0008877_abnormal_DNA_methylation3.41151650
7MP0008875_abnormal_xenobiotic_pharmacok3.15501333
8MP0003252_abnormal_bile_duct3.06546960
9MP0006292_abnormal_olfactory_placode2.91709140
10MP0008789_abnormal_olfactory_epithelium2.77822120
11MP0005499_abnormal_olfactory_system2.72438243
12MP0005394_taste/olfaction_phenotype2.72438243
13MP0003300_gastrointestinal_ulcer2.70104883
14MP0010329_abnormal_lipoprotein_level2.54801936
15MP0005646_abnormal_pituitary_gland2.49783804
16MP0003183_abnormal_peptide_metabolism2.41531500
17MP0003890_abnormal_embryonic-extraembry2.39490987
18MP0003122_maternal_imprinting2.31320800
19MP0005379_endocrine/exocrine_gland_phen2.30868810
20MP0000427_abnormal_hair_cycle2.28298824
21MP0002653_abnormal_ependyma_morphology2.27998855
22MP0003121_genomic_imprinting2.26613169
23MP0001666_abnormal_nutrient_absorption2.14570917
24MP0000569_abnormal_digit_pigmentation2.10904500
25MP0005248_abnormal_Harderian_gland2.10714329
26MP0009840_abnormal_foam_cell2.07601611
27MP0001835_abnormal_antigen_presentation1.99967477
28MP0002166_altered_tumor_susceptibility1.97496218
29MP0003868_abnormal_feces_composition1.97146238
30MP0008057_abnormal_DNA_replication1.96474019
31MP0006276_abnormal_autonomic_nervous1.94478215
32MP0005187_abnormal_penis_morphology1.92848478
33MP0006072_abnormal_retinal_apoptosis1.88929926
34MP0005464_abnormal_platelet_physiology1.81005116
35MP0000465_gastrointestinal_hemorrhage1.78325247
36MP0005253_abnormal_eye_physiology1.77288761
37MP0000778_abnormal_nervous_system1.76620477
38MP0003172_abnormal_lysosome_physiology1.73731099
39MP0002138_abnormal_hepatobiliary_system1.71944245
40MP0002163_abnormal_gland_morphology1.71533032
41MP0005645_abnormal_hypothalamus_physiol1.70261742
42MP0005083_abnormal_biliary_tract1.66088007
43MP0010368_abnormal_lymphatic_system1.65222213
44MP0000685_abnormal_immune_system1.59531942
45MP0001529_abnormal_vocalization1.59048955
46MP0003724_increased_susceptibility_to1.58604031
47MP0002909_abnormal_adrenal_gland1.58098568
48MP0005058_abnormal_lysosome_morphology1.56843953
49MP0006054_spinal_hemorrhage1.56624291
50MP0002877_abnormal_melanocyte_morpholog1.54715847
51MP0000609_abnormal_liver_physiology1.52963216
52MP0002118_abnormal_lipid_homeostasis1.52156662
53MP0008438_abnormal_cutaneous_collagen1.51353542
54MP0001984_abnormal_olfaction1.50190334
55MP0005174_abnormal_tail_pigmentation1.46127695
56MP0000383_abnormal_hair_follicle1.45514455
57MP0002837_dystrophic_cardiac_calcinosis1.45062444
58MP0003195_calcinosis1.42435577
59MP0005332_abnormal_amino_acid1.42253683
60MP0003191_abnormal_cellular_cholesterol1.42063307
61MP0005671_abnormal_response_to1.41464789
62MP0002233_abnormal_nose_morphology1.40384732
63MP0004133_heterotaxia1.39949316
64MP0002928_abnormal_bile_duct1.39665824
65MP0005408_hypopigmentation1.37240119
66MP0002102_abnormal_ear_morphology1.36780663
67MP0002419_abnormal_innate_immunity1.34776999
68MP0002822_catalepsy1.32866552
69MP0003880_abnormal_central_pattern1.26455134
70MP0000631_abnormal_neuroendocrine_gland1.25395801
71MP0005584_abnormal_enzyme/coenzyme_acti1.25084754
72MP0004019_abnormal_vitamin_homeostasis1.24907020
73MP0001873_stomach_inflammation1.20365201
74MP0005387_immune_system_phenotype1.19799587
75MP0001790_abnormal_immune_system1.19799587
76MP0005410_abnormal_fertilization1.18563674
77MP0005220_abnormal_exocrine_pancreas1.17211614
78MP0003279_aneurysm1.15450838
79MP0001986_abnormal_taste_sensitivity1.15008607
80MP0003690_abnormal_glial_cell1.14302769
81MP0002254_reproductive_system_inflammat1.13216025
82MP0002006_tumorigenesis1.13200658
83MP0009643_abnormal_urine_homeostasis1.12354739
84MP0009764_decreased_sensitivity_to1.12118755
85MP0005025_abnormal_response_to1.10679183
86MP0001486_abnormal_startle_reflex1.10559537
87MP0008995_early_reproductive_senescence1.09910561
88MP0010155_abnormal_intestine_physiology1.09483279
89MP0009785_altered_susceptibility_to1.09196885
90MP0002638_abnormal_pupillary_reflex1.08255018
91MP0001270_distended_abdomen1.07497882
92MP0000647_abnormal_sebaceous_gland1.06075112
93MP0008469_abnormal_protein_level1.03686967
94MP0002396_abnormal_hematopoietic_system1.03583516
95MP0003436_decreased_susceptibility_to1.03312201
96MP0004134_abnormal_chest_morphology1.03213589
97MP0005075_abnormal_melanosome_morpholog1.02533032
98MP0010678_abnormal_skin_adnexa1.02139461
99MP0000604_amyloidosis1.01315028
100MP0005310_abnormal_salivary_gland1.01298775
101MP0005319_abnormal_enzyme/_coenzyme1.01232059
102MP0001853_heart_inflammation1.00505574
103MP0005195_abnormal_posterior_eye1.00109051
104MP0002751_abnormal_autonomic_nervous0.99972075
105MP0002557_abnormal_social/conspecific_i0.99452029
106MP0009780_abnormal_chondrocyte_physiolo0.99055118
107MP0005000_abnormal_immune_tolerance0.98604512
108MP0002272_abnormal_nervous_system0.98162893
109MP0001845_abnormal_inflammatory_respons0.98080102
110MP0004742_abnormal_vestibular_system0.98063917
111MP0004808_abnormal_hematopoietic_stem0.98044748
112MP0001879_abnormal_lymphatic_vessel0.97411077
113MP0001485_abnormal_pinna_reflex0.95593798
114MP0002184_abnormal_innervation0.95303108
115MP0003303_peritoneal_inflammation0.94836632
116MP0001800_abnormal_humoral_immune0.94459023
117MP0005397_hematopoietic_system_phenotyp0.93468981
118MP0001545_abnormal_hematopoietic_system0.93468981
119MP0005389_reproductive_system_phenotype0.93182989
120MP0001324_abnormal_eye_pigmentation0.92884439
121MP0002752_abnormal_somatic_nervous0.92598172
122MP0005334_abnormal_fat_pad0.91749832
123MP0002452_abnormal_antigen_presenting0.91154063
124MP0000371_diluted_coat_color0.90610441
125MP0000598_abnormal_liver_morphology0.90516918
126MP0002998_abnormal_bone_remodeling0.90067016
127MP0006082_CNS_inflammation0.89281034
128MP0002723_abnormal_immune_serum0.88986145
129MP0009765_abnormal_xenobiotic_induced0.88146350
130MP0005391_vision/eye_phenotype0.87879968
131MP0009763_increased_sensitivity_to0.87685149
132MP0004947_skin_inflammation0.87617307
133MP0004381_abnormal_hair_follicle0.87474053
134MP0008004_abnormal_stomach_pH0.86725382
135MP0004142_abnormal_muscle_tone0.86604214
136MP0009046_muscle_twitch0.86358103
137MP0001533_abnormal_skeleton_physiology0.86346099
138MP0002067_abnormal_sensory_capabilities0.86184659
139MP0003698_abnormal_male_reproductive0.86096924
140MP0004130_abnormal_muscle_cell0.85342115
141MP0002933_joint_inflammation0.84733845
142MP0001188_hyperpigmentation0.84184533
143MP0000920_abnormal_myelination0.82919449
144MP0003656_abnormal_erythrocyte_physiolo0.82639300
145MP0002420_abnormal_adaptive_immunity0.82601246
146MP0000955_abnormal_spinal_cord0.82570039
147MP0002095_abnormal_skin_pigmentation0.82470917
148MP0003011_delayed_dark_adaptation0.81210006
149MP0003075_altered_response_to0.80695955
150MP0002090_abnormal_vision0.80574086
151MP0001819_abnormal_immune_cell0.80369055
152MP0001944_abnormal_pancreas_morphology0.79618675
153MP0001501_abnormal_sleep_pattern0.79457635
154MP0002882_abnormal_neuron_morphology0.79359219
155MP0003638_abnormal_response/metabolism_0.77430470
156MP0000015_abnormal_ear_pigmentation0.76619443
157MP0001919_abnormal_reproductive_system0.76347290
158MP0004885_abnormal_endolymph0.76039886
159MP0002693_abnormal_pancreas_physiology0.75638864
160MP0001851_eye_inflammation0.74598380
161MP0003943_abnormal_hepatobiliary_system0.74526355
162MP0002572_abnormal_emotion/affect_behav0.74142193
163MP0002009_preneoplasia0.72810188
164MP0002136_abnormal_kidney_physiology0.72728557
165MP0003763_abnormal_thymus_physiology0.72317556
166MP0000372_irregular_coat_pigmentation0.72073638
167MP0005551_abnormal_eye_electrophysiolog0.71833919
168MP0002160_abnormal_reproductive_system0.71324615
169MP0005386_behavior/neurological_phenoty0.70295130
170MP0004924_abnormal_behavior0.70295130
171MP0004811_abnormal_neuron_physiology0.69977270
172MP0001929_abnormal_gametogenesis0.68251268
173MP0000049_abnormal_middle_ear0.66832633
174MP0001542_abnormal_bone_strength0.66432179
175MP0000639_abnormal_adrenal_gland0.66339672
176MP0003938_abnormal_ear_development0.65576450
177MP0001293_anophthalmia0.63437746
178MP0003632_abnormal_nervous_system0.62800953
179MP0001756_abnormal_urination0.62642355
180MP0003119_abnormal_digestive_system0.61456937
181MP0003937_abnormal_limbs/digits/tail_de0.60746230

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.79370566
2Deep venous thrombosis (HP:0002625)4.56352729
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.51550710
4Chronic hepatic failure (HP:0100626)4.12882641
5Abnormality of the common coagulation pathway (HP:0010990)4.01103400
6Xanthomatosis (HP:0000991)3.98425469
7Pancreatic cysts (HP:0001737)3.95091458
8Complement deficiency (HP:0004431)3.93806833
9Pancreatic fibrosis (HP:0100732)3.86319765
10Nephronophthisis (HP:0000090)3.65308563
11Medial flaring of the eyebrow (HP:0010747)3.64765220
12Prolonged partial thromboplastin time (HP:0003645)3.59495377
13Abnormality of midbrain morphology (HP:0002418)3.58724634
14Molar tooth sign on MRI (HP:0002419)3.58724634
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57669166
16True hermaphroditism (HP:0010459)3.56769993
17Tubulointerstitial nephritis (HP:0001970)3.47064926
18Abnormality of the renal medulla (HP:0100957)3.34165667
19Hyperlipoproteinemia (HP:0010980)3.20615517
20Gingival bleeding (HP:0000225)3.20535068
21Abnormality of the intrinsic pathway (HP:0010989)3.14142842
22Joint hemorrhage (HP:0005261)3.13807708
23Gait imbalance (HP:0002141)3.11503436
24Congenital primary aphakia (HP:0007707)3.10011211
25Systemic lupus erythematosus (HP:0002725)3.00512531
26Abnormality of the renal cortex (HP:0011035)2.96270006
27Intestinal atresia (HP:0011100)2.96192086
28Nephrogenic diabetes insipidus (HP:0009806)2.91946986
29Abnormality of complement system (HP:0005339)2.91631442
30Hypobetalipoproteinemia (HP:0003563)2.89745052
31Tubular atrophy (HP:0000092)2.84584656
32Hyperventilation (HP:0002883)2.82672700
33Hypoglycemic coma (HP:0001325)2.79834748
34Progressive cerebellar ataxia (HP:0002073)2.78728430
35Hepatoblastoma (HP:0002884)2.77178901
36Conjugated hyperbilirubinemia (HP:0002908)2.76505433
37Menorrhagia (HP:0000132)2.72489880
38Mitral stenosis (HP:0001718)2.72450960
39Epidermoid cyst (HP:0200040)2.70886156
40Hypoglycemic seizures (HP:0002173)2.69062987
41Bony spicule pigmentary retinopathy (HP:0007737)2.68433621
42Abnormality of macular pigmentation (HP:0008002)2.67949701
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67900122
44Epistaxis (HP:0000421)2.66785617
45Dysostosis multiplex (HP:0000943)2.63442994
46Spontaneous hematomas (HP:0007420)2.61477890
47Urinary glycosaminoglycan excretion (HP:0003541)2.60780485
48Mucopolysacchariduria (HP:0008155)2.60780485
49Drooling (HP:0002307)2.60149794
50Fat malabsorption (HP:0002630)2.59903456
51Poor coordination (HP:0002370)2.59521199
52Glomerulonephritis (HP:0000099)2.59115641
53Prolonged bleeding time (HP:0003010)2.57407464
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53862942
55Postaxial foot polydactyly (HP:0001830)2.53432813
56Pulmonary embolism (HP:0002204)2.52983139
57Papillary thyroid carcinoma (HP:0002895)2.50049344
58Abnormal rod and cone electroretinograms (HP:0008323)2.49983255
59Excessive salivation (HP:0003781)2.48621231
60Abnormal pancreas size (HP:0012094)2.48597911
61Protuberant abdomen (HP:0001538)2.46374000
62Hip dysplasia (HP:0001385)2.44671641
63Recurrent gram-negative bacterial infections (HP:0005420)2.44588605
64Genital tract atresia (HP:0001827)2.44497461
65Ketosis (HP:0001946)2.43456862
66Hematochezia (HP:0002573)2.39830529
67Absent speech (HP:0001344)2.38042156
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38029121
69Abnormality of polysaccharide metabolism (HP:0011012)2.38029121
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38029121
71Abnormal platelet function (HP:0011869)2.37947136
72Impaired platelet aggregation (HP:0003540)2.37947136
73Renal cortical cysts (HP:0000803)2.37752389
74Thin bony cortex (HP:0002753)2.36656585
75Amyloidosis (HP:0011034)2.36351873
76Myocardial infarction (HP:0001658)2.35974477
77Tubulointerstitial abnormality (HP:0001969)2.34138874
78Vaginal atresia (HP:0000148)2.33200573
79Esophageal varix (HP:0002040)2.32972865
80Adrenal hypoplasia (HP:0000835)2.32427249
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.31923922
82Attenuation of retinal blood vessels (HP:0007843)2.31297647
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.31246593
84Absent/shortened dynein arms (HP:0200106)2.31246593
85Abnormal platelet volume (HP:0011876)2.29578550
86Hypercholesterolemia (HP:0003124)2.28745091
87Abolished electroretinogram (ERG) (HP:0000550)2.28283197
88Increased mean platelet volume (HP:0011877)2.27731786
89Hypolipoproteinemia (HP:0010981)2.25030409
90Purpura (HP:0000979)2.22546036
91Thrombophlebitis (HP:0004418)2.21227694
92Enlarged kidneys (HP:0000105)2.21147389
93Symptomatic seizures (HP:0011145)2.20969214
94Cystic liver disease (HP:0006706)2.19169547
95Widely spaced teeth (HP:0000687)2.18559737
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17855095
97Postaxial hand polydactyly (HP:0001162)2.17551727
98Congenital hepatic fibrosis (HP:0002612)2.17434635
99Abnormal ciliary motility (HP:0012262)2.17067363
100Hyperbilirubinemia (HP:0002904)2.16771073
101Abnormality of sulfur amino acid metabolism (HP:0004339)2.15492706
102Abnormality of the lumbar spine (HP:0100712)2.15327378
103Thyroid carcinoma (HP:0002890)2.15278652
104Progressive inability to walk (HP:0002505)2.12675959
105Growth hormone deficiency (HP:0000824)2.12366524
106Periodontitis (HP:0000704)2.12228502
107Osteomalacia (HP:0002749)2.11328845
108Abnormality of fatty-acid metabolism (HP:0004359)2.10597517
109Hypoalphalipoproteinemia (HP:0003233)2.10004192
110Macroorchidism (HP:0000053)2.09778310
111Gaze-evoked nystagmus (HP:0000640)2.07587159
112Hepatocellular carcinoma (HP:0001402)2.06276238
113Inability to walk (HP:0002540)2.05970705
114Retinitis pigmentosa (HP:0000510)2.04705220
115Myositis (HP:0100614)2.04454154
116Anencephaly (HP:0002323)2.04393301
117Congenital stationary night blindness (HP:0007642)2.03296336
118Amyotrophic lateral sclerosis (HP:0007354)2.02289699
119Thyroiditis (HP:0100646)2.00776826
120Median cleft lip (HP:0000161)2.00527377
121Vitreoretinal degeneration (HP:0000655)1.99972035
122Abnormal respiratory epithelium morphology (HP:0012253)1.99960243
123Abnormal respiratory motile cilium morphology (HP:0005938)1.99960243
124Microcytic anemia (HP:0001935)1.97822906
125Pendular nystagmus (HP:0012043)1.97447863
126Chronic otitis media (HP:0000389)1.97159794
127Bile duct proliferation (HP:0001408)1.96784890
128Abnormal biliary tract physiology (HP:0012439)1.96784890
129Acanthocytosis (HP:0001927)1.96175674
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94270864
131Lissencephaly (HP:0001339)1.92344895
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.91980490
133Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91980490
134Broad-based gait (HP:0002136)1.91707126
135Pachygyria (HP:0001302)1.89563209
136Type II lissencephaly (HP:0007260)1.89091369
137Ketoacidosis (HP:0001993)1.88993606
138Bifid tongue (HP:0010297)1.88989766
139Neoplasm of the adrenal cortex (HP:0100641)1.88892777
140Severe visual impairment (HP:0001141)1.88210001
141Sensorimotor neuropathy (HP:0007141)1.87702826
142Pancreatitis (HP:0001733)1.87466647
143Narrow forehead (HP:0000341)1.86709559
144Specific learning disability (HP:0001328)1.86699050
145Abnormality of proline metabolism (HP:0010907)1.86539410
146Hydroxyprolinuria (HP:0003080)1.86539410
147Abdominal distention (HP:0003270)1.86304025
148Labial hypoplasia (HP:0000066)1.85669234
149Optic nerve hypoplasia (HP:0000609)1.85100528
150Occipital encephalocele (HP:0002085)1.85059183
151Volvulus (HP:0002580)1.84783629
152Hyperammonemia (HP:0001987)1.84657077
153Short foot (HP:0001773)1.83850033
154Nephritis (HP:0000123)1.82682584
155Vacuolated lymphocytes (HP:0001922)1.82669820
156Steatorrhea (HP:0002570)1.81577003
157Arterial thrombosis (HP:0004420)1.81561130
158Decreased central vision (HP:0007663)1.81319051
159Genetic anticipation (HP:0003743)1.80967692
160Metaphyseal dysplasia (HP:0100255)1.79444270
161Abnormality of methionine metabolism (HP:0010901)1.78472644
162Growth hormone excess (HP:0000845)1.77413442
163Papilledema (HP:0001085)1.76870106
164Limb dystonia (HP:0002451)1.76677929
165IgM deficiency (HP:0002850)1.75936628
166Spondylolisthesis (HP:0003302)1.75752877
167Astigmatism (HP:0000483)1.74967529
168Abnormal drinking behavior (HP:0030082)1.74002762
169Polydipsia (HP:0001959)1.74002762
170Recurrent cutaneous fungal infections (HP:0011370)1.73968376
171Chronic mucocutaneous candidiasis (HP:0002728)1.73968376
172Interstitial pulmonary disease (HP:0006530)1.73696463
173Agitation (HP:0000713)1.73618342
174Impaired vibration sensation in the lower limbs (HP:0002166)1.73575234
175Curly hair (HP:0002212)1.72461256
176Male pseudohermaphroditism (HP:0000037)1.72346496
177Blue irides (HP:0000635)1.72291816
178Elevated erythrocyte sedimentation rate (HP:0003565)1.71455378
179Broad foot (HP:0001769)1.71287049
180Anosmia (HP:0000458)1.70119294
181Elevated alkaline phosphatase (HP:0003155)1.70084607
182Polyphagia (HP:0002591)1.69919129
183Oligodactyly (hands) (HP:0001180)1.69054411
184Hypoplasia of the thymus (HP:0000778)1.68904338
185Dyskinesia (HP:0100660)1.68715148
186Increased corneal curvature (HP:0100692)1.67098319
187Keratoconus (HP:0000563)1.67098319
188Retinal atrophy (HP:0001105)1.65811887
189Abnormal respiratory motile cilium physiology (HP:0012261)1.65541057
190Recurrent viral infections (HP:0004429)1.65056552
191Abnormality of purine metabolism (HP:0004352)1.64432339
192Gastrointestinal infarctions (HP:0005244)1.64428385
193Cardiomegaly (HP:0001640)1.63915677
194Abnormal enzyme/coenzyme activity (HP:0012379)1.63765250
195Inflammation of the large intestine (HP:0002037)1.63166497
196Hemorrhage of the eye (HP:0011885)1.62474201
197Eczematoid dermatitis (HP:0000976)1.62340258
198Increased CSF protein (HP:0002922)1.60584270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.76926538
2TAOK32.97340185
3BRSK22.92481110
4MAP3K42.92069739
5FGFR42.88293347
6TGFBR22.86485644
7PINK12.69354059
8MAP4K22.60626201
9STK38L2.50018228
10ERN12.47290261
11CASK2.42722370
12MAP2K72.29047962
13SIK12.24910181
14FGFR22.22519845
15FGFR32.19096047
16WNK32.13328564
17MAP4K12.10260388
18PKN22.10030607
19BRD42.06071485
20EPHB12.03267079
21PTK61.95605755
22ACVR1B1.89816381
23CAMKK21.85007973
24TIE11.75965771
25DYRK31.72894183
26BCR1.71435479
27KIT1.68793734
28MAPKAPK51.66629396
29EPHA31.63949366
30TYK21.63805379
31JAK11.61658410
32ITK1.61614649
33MAP2K41.59644838
34JAK31.52754958
35PAK31.51795242
36MAPK131.51565533
37MST1R1.49980226
38TRIB31.48915585
39EEF2K1.48559618
40BMPR1B1.47953068
41MAP3K131.45954483
42BTK1.43358121
43TEC1.40891425
44NEK91.39860466
45TBK11.38221683
46ZAP701.35675572
47TGFBR11.35656234
48TRIM281.32750010
49AKT31.29124721
50FRK1.27896260
51HIPK21.27714443
52TXK1.26993030
53RIPK41.25680669
54RET1.22927492
55ADRBK21.22649932
56MAPK151.21733922
57CSNK1G21.19941498
58CDK191.19548114
59MARK31.17213056
60TRPM71.15914684
61GRK11.15261458
62TAOK11.14789844
63CAMK1G1.11754516
64DYRK21.11549013
65MAP3K141.11165542
66JAK21.10284790
67FLT31.09692813
68MAP3K71.08431312
69IKBKE1.07740184
70PLK21.07589521
71CAMK1D1.05579509
72CSNK1G31.04539478
73DYRK1A1.02568663
74TNIK1.00690519
75MARK10.99301461
76MARK20.99281389
77BLK0.98112989
78RIPK10.96568379
79MKNK20.95575690
80PDGFRB0.95194909
81CSF1R0.93910407
82SGK30.92907429
83PRKCH0.91301805
84ERBB30.91092009
85STK380.90689575
86LATS10.90161131
87LRRK20.89880361
88PRKCE0.89052089
89CSNK1A1L0.87964715
90PDGFRA0.87178455
91STK110.85974854
92NLK0.85922223
93SYK0.84088144
94LCK0.83050314
95HCK0.81959062
96STK30.81243722
97BCKDK0.81151070
98PDK10.81055872
99PLK40.80236152
100ZAK0.79468287
101CSK0.79270467
102NTRK30.79252597
103DAPK20.77281782
104DYRK1B0.75451526
105MATK0.75290121
106MST40.74183517
107CDK60.72083474
108ERBB20.71664407
109DMPK0.69440925
110WNK10.68220633
111PRKCQ0.67844396
112IGF1R0.67749787
113MKNK10.67378339
114LYN0.65973475
115STK100.65743269
116MAP2K30.65570766
117STK390.65259906
118MAP3K50.64841493
119PDPK10.63598133
120MAP3K100.62684718
121MAPK70.62082771
122SIK30.61400391
123IRAK40.59994118
124WNK40.59953391
125SGK2230.58839861
126SGK4940.58839861
127MINK10.56782848
128CSNK1D0.56279007
129FES0.56264567
130TNK20.55290976
131KDR0.55240299
132FER0.53870831
133IRAK10.53867613
134OXSR10.53661571
135YES10.53354023
136PTK2B0.53302480
137MAP2K20.53140620
138PRKD10.51435842
139SCYL20.50728201
140MAPK40.49858671
141SGK20.49305096
142FGFR10.48828167
143GSK3A0.47860208
144NUAK10.47449173
145PRKCG0.45971116
146STK240.45305435
147CSNK1G10.45304863
148FYN0.45067842
149BMPR20.44867951
150MAP3K20.43980444
151EGFR0.43800367
152IRAK30.43643399
153PRKCZ0.42240820
154PRKG10.42223608
155MAP3K10.42106415
156RPS6KA20.41757722
157IKBKB0.41371627
158ADRBK10.41320151
159PRKAA20.41047131
160MAP3K60.40472389
161SGK10.39197716
162EIF2AK30.38966454
163CDK50.38815815
164CAMK40.35428848
165PIK3CA0.35187191
166KSR10.35057998

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.98744296
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.46926312
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65772436
4Complement and coagulation cascades_Homo sapiens_hsa046102.55206397
5Phototransduction_Homo sapiens_hsa047442.51718550
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44407105
7Fatty acid degradation_Homo sapiens_hsa000712.20933423
8Circadian rhythm_Homo sapiens_hsa047102.14201327
9Staphylococcus aureus infection_Homo sapiens_hsa051502.14194558
10Caffeine metabolism_Homo sapiens_hsa002322.09487568
11Tryptophan metabolism_Homo sapiens_hsa003802.01679517
12Regulation of autophagy_Homo sapiens_hsa041401.94156665
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.92972018
14Sulfur metabolism_Homo sapiens_hsa009201.90782984
15Arginine biosynthesis_Homo sapiens_hsa002201.88103084
16Histidine metabolism_Homo sapiens_hsa003401.80260056
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77078111
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64853905
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61943436
20ABC transporters_Homo sapiens_hsa020101.59210463
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57546639
22Peroxisome_Homo sapiens_hsa041461.57277072
23Fatty acid metabolism_Homo sapiens_hsa012121.54681735
24Dopaminergic synapse_Homo sapiens_hsa047281.52177551
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.49532804
26PPAR signaling pathway_Homo sapiens_hsa033201.49302985
27Morphine addiction_Homo sapiens_hsa050321.42188134
28Butanoate metabolism_Homo sapiens_hsa006501.41123576
29Linoleic acid metabolism_Homo sapiens_hsa005911.39864485
30Taste transduction_Homo sapiens_hsa047421.37862390
31Ether lipid metabolism_Homo sapiens_hsa005651.36410557
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35760488
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35033819
34Olfactory transduction_Homo sapiens_hsa047401.34723415
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33016482
36Fatty acid elongation_Homo sapiens_hsa000621.32485698
37GABAergic synapse_Homo sapiens_hsa047271.31679474
38Non-homologous end-joining_Homo sapiens_hsa034501.28885802
39Bile secretion_Homo sapiens_hsa049761.28522314
40Selenocompound metabolism_Homo sapiens_hsa004501.25788360
41Protein export_Homo sapiens_hsa030601.25751717
42Propanoate metabolism_Homo sapiens_hsa006401.25499178
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22038161
44Chemical carcinogenesis_Homo sapiens_hsa052041.21060526
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20712023
46Serotonergic synapse_Homo sapiens_hsa047261.19477634
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18393306
48Glutamatergic synapse_Homo sapiens_hsa047241.17220784
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16193043
50Nicotine addiction_Homo sapiens_hsa050331.15829369
51beta-Alanine metabolism_Homo sapiens_hsa004101.15823969
52Retinol metabolism_Homo sapiens_hsa008301.13672661
53Lysine degradation_Homo sapiens_hsa003101.11114960
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10930960
55Long-term depression_Homo sapiens_hsa047301.09860673
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08355775
57Starch and sucrose metabolism_Homo sapiens_hsa005001.07184005
58Steroid biosynthesis_Homo sapiens_hsa001001.06492506
59Tyrosine metabolism_Homo sapiens_hsa003501.06175700
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05806232
61Basal transcription factors_Homo sapiens_hsa030221.04694542
62Sphingolipid metabolism_Homo sapiens_hsa006001.04374449
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.00481235
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99459804
65Circadian entrainment_Homo sapiens_hsa047130.98163327
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95850891
67Hedgehog signaling pathway_Homo sapiens_hsa043400.94419472
68Inositol phosphate metabolism_Homo sapiens_hsa005620.90982107
69Lysosome_Homo sapiens_hsa041420.85820042
70Osteoclast differentiation_Homo sapiens_hsa043800.85315790
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84382522
72Insulin secretion_Homo sapiens_hsa049110.83891318
73Fanconi anemia pathway_Homo sapiens_hsa034600.83219136
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.82619923
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81235156
76Collecting duct acid secretion_Homo sapiens_hsa049660.78313825
77Leishmaniasis_Homo sapiens_hsa051400.76967225
78Insulin resistance_Homo sapiens_hsa049310.75949371
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74831209
80Phenylalanine metabolism_Homo sapiens_hsa003600.73455245
81Type I diabetes mellitus_Homo sapiens_hsa049400.73125025
82B cell receptor signaling pathway_Homo sapiens_hsa046620.72305731
83Pertussis_Homo sapiens_hsa051330.70540918
84FoxO signaling pathway_Homo sapiens_hsa040680.70361666
85Glycerolipid metabolism_Homo sapiens_hsa005610.68312921
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.67738275
87Axon guidance_Homo sapiens_hsa043600.67235840
88RNA degradation_Homo sapiens_hsa030180.66327845
89Folate biosynthesis_Homo sapiens_hsa007900.65849234
90mTOR signaling pathway_Homo sapiens_hsa041500.65289842
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64636054
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64303421
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.63879013
94Platelet activation_Homo sapiens_hsa046110.63039120
95Phagosome_Homo sapiens_hsa041450.62690122
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61653566
97Malaria_Homo sapiens_hsa051440.61440421
98Cholinergic synapse_Homo sapiens_hsa047250.60305997
99TGF-beta signaling pathway_Homo sapiens_hsa043500.58818917
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58404267
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57932479
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57645692
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56684488
104Prion diseases_Homo sapiens_hsa050200.56453491
105Renin secretion_Homo sapiens_hsa049240.56333929
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56305219
107Hematopoietic cell lineage_Homo sapiens_hsa046400.56303470
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55633854
109mRNA surveillance pathway_Homo sapiens_hsa030150.54614317
110Amphetamine addiction_Homo sapiens_hsa050310.52577050
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.52254565
112Choline metabolism in cancer_Homo sapiens_hsa052310.51888161
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50935562
114Arachidonic acid metabolism_Homo sapiens_hsa005900.49696879
115N-Glycan biosynthesis_Homo sapiens_hsa005100.49178346
116Fat digestion and absorption_Homo sapiens_hsa049750.49093522
117Ras signaling pathway_Homo sapiens_hsa040140.48985901
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48643649
119Oxytocin signaling pathway_Homo sapiens_hsa049210.47534418
120T cell receptor signaling pathway_Homo sapiens_hsa046600.46740110
121Dorso-ventral axis formation_Homo sapiens_hsa043200.46028133
122Antigen processing and presentation_Homo sapiens_hsa046120.44493799
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44291566
124cAMP signaling pathway_Homo sapiens_hsa040240.44215860
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.43568946
126Toxoplasmosis_Homo sapiens_hsa051450.43156830
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43009474
128Pancreatic cancer_Homo sapiens_hsa052120.42681531
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42110726
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41389908
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.41324960
132Type II diabetes mellitus_Homo sapiens_hsa049300.40875392
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40837765
134Tuberculosis_Homo sapiens_hsa051520.39874313
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39847047
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39413415
137ECM-receptor interaction_Homo sapiens_hsa045120.39399648
138Vitamin digestion and absorption_Homo sapiens_hsa049770.39319473
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39245648
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.38784073
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.38767567
142Chemokine signaling pathway_Homo sapiens_hsa040620.38463143
143Hippo signaling pathway_Homo sapiens_hsa043900.37947397
144Chronic myeloid leukemia_Homo sapiens_hsa052200.37677750
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37663794
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37525043
147Gap junction_Homo sapiens_hsa045400.37468375
148Other glycan degradation_Homo sapiens_hsa005110.37276635
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36392410
150Pyruvate metabolism_Homo sapiens_hsa006200.36216688
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36092658
152Fatty acid biosynthesis_Homo sapiens_hsa000610.36066156
153Hepatitis C_Homo sapiens_hsa051600.35748312
154Ovarian steroidogenesis_Homo sapiens_hsa049130.34587553
155Amoebiasis_Homo sapiens_hsa051460.33611143
156Measles_Homo sapiens_hsa051620.33105770
157TNF signaling pathway_Homo sapiens_hsa046680.31757223
158Prolactin signaling pathway_Homo sapiens_hsa049170.31683894
159AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30936336
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30816634
161Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30659922
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29839558
163African trypanosomiasis_Homo sapiens_hsa051430.29350309
164Primary immunodeficiency_Homo sapiens_hsa053400.29194157
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28780587

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