ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.66114284
2	viral transcription (GO:0019083)	6.29119760
3	DNA deamination (GO:0045006)	6.24769787
4	translational termination (GO:0006415)	6.05643670
5	ribosomal small subunit biogenesis (GO:0042274)	5.84098688
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.54290915
7	cotranslational protein targeting to membrane (GO:0006613)	5.45097864
8	protein targeting to ER (GO:0045047)	5.40728286
9	translational elongation (GO:0006414)	5.40201671
10	protein localization to endoplasmic reticulum (GO:0070972)	5.16200064
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.10111179
12	maturation of SSU-rRNA (GO:0030490)	4.96740460
13	viral life cycle (GO:0019058)	4.81656985
14	translational initiation (GO:0006413)	4.71024251
15	cellular protein complex disassembly (GO:0043624)	4.70987216
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.63525966
17	proteasome assembly (GO:0043248)	4.62011671
18	ribosomal large subunit biogenesis (GO:0042273)	4.56513952
19	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.39366096
20	cytochrome complex assembly (GO:0017004)	4.37469726
21	translation (GO:0006412)	4.32011710
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.30585020
23	protein neddylation (GO:0045116)	4.24693058
24	telomere maintenance via semi-conservative replication (GO:0032201)	4.14248074
25	protein complex disassembly (GO:0043241)	4.06093728
26	ATP synthesis coupled proton transport (GO:0015986)	4.05140790
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.05140790
28	ATP biosynthetic process (GO:0006754)	4.04287491
29	DNA strand elongation involved in DNA replication (GO:0006271)	4.01889084
30	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.00973723
31	ribonucleoprotein complex biogenesis (GO:0022613)	3.89359959
32	macromolecular complex disassembly (GO:0032984)	3.86043172
33	regulation of mitochondrial translation (GO:0070129)	3.85207014
34	hydrogen ion transmembrane transport (GO:1902600)	3.84352109
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.84031362
36	DNA strand elongation (GO:0022616)	3.83390020
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.83259867
38	formation of translation preinitiation complex (GO:0001731)	3.73725342
39	spliceosomal snRNP assembly (GO:0000387)	3.72969668
40	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.67876932
41	inner mitochondrial membrane organization (GO:0007007)	3.67573092
42	termination of RNA polymerase III transcription (GO:0006386)	3.65136528
43	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.65136528
44	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.64598984
45	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.64586726
46	negative regulation of ligase activity (GO:0051352)	3.63940173
47	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.63940173
48	protein localization to mitochondrion (GO:0070585)	3.62768943
49	establishment of integrated proviral latency (GO:0075713)	3.61572583
50	regulation of cellular amino acid metabolic process (GO:0006521)	3.61385908
51	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.60471518
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.57821370
53	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.56505519
54	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.56505519
55	pseudouridine synthesis (GO:0001522)	3.56218373
56	rRNA processing (GO:0006364)	3.55805246
57	cellular component biogenesis (GO:0044085)	3.55234607
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.54905196
59	telomere maintenance via recombination (GO:0000722)	3.54145118
60	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53988829
61	NADH dehydrogenase complex assembly (GO:0010257)	3.53988829
62	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53988829
63	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.52652260
64	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.52652260
65	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.52652260
66	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.52127667
67	protein targeting to membrane (GO:0006612)	3.51904601
68	rRNA modification (GO:0000154)	3.51652317
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.51102737
70	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.50377379
71	protein complex biogenesis (GO:0070271)	3.47800959
72	oxidative phosphorylation (GO:0006119)	3.47301968
73	cullin deneddylation (GO:0010388)	3.46941332
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.44477628
75	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.44395332
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.42493579
77	protein deneddylation (GO:0000338)	3.42417208
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.42394300
79	respiratory electron transport chain (GO:0022904)	3.41402703
80	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.40535238
81	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.40535238
82	protein targeting to mitochondrion (GO:0006626)	3.39728394
83	rRNA metabolic process (GO:0016072)	3.39070887
84	intracellular protein transmembrane import (GO:0044743)	3.38633463
85	respiratory chain complex IV assembly (GO:0008535)	3.37048500
86	mRNA catabolic process (GO:0006402)	3.35559537
87	chaperone-mediated protein transport (GO:0072321)	3.35519898
88	proton transport (GO:0015992)	3.35498011
89	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35377840
90	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.35235303
91	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.34767192
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.34767192
93	mitochondrial transport (GO:0006839)	3.32994999
94	electron transport chain (GO:0022900)	3.32943198
95	establishment of protein localization to mitochondrion (GO:0072655)	3.31366748
96	DNA replication initiation (GO:0006270)	3.31233715
97	chromatin remodeling at centromere (GO:0031055)	3.30810799
98	hydrogen transport (GO:0006818)	3.29077197
99	spliceosomal complex assembly (GO:0000245)	3.24767584
100	peptidyl-histidine modification (GO:0018202)	3.24645215
101	transcription-coupled nucleotide-excision repair (GO:0006283)	3.23046464
102	7-methylguanosine mRNA capping (GO:0006370)	3.22592679
103	aerobic respiration (GO:0009060)	3.21066770
104	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.20963301
105	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20141736
106	nucleoside triphosphate biosynthetic process (GO:0009142)	3.19858881
107	7-methylguanosine RNA capping (GO:0009452)	3.19056483
108	RNA capping (GO:0036260)	3.19056483
109	water-soluble vitamin biosynthetic process (GO:0042364)	3.17997401
110	mitotic recombination (GO:0006312)	3.17758212
111	RNA catabolic process (GO:0006401)	3.17683949
112	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.17456973
113	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.17435684
114	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.17435684
115	CENP-A containing nucleosome assembly (GO:0034080)	3.17367663
116	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.16570698
117	deoxyribose phosphate biosynthetic process (GO:0046385)	3.16570698
118	GTP biosynthetic process (GO:0006183)	3.14574903
119	DNA replication checkpoint (GO:0000076)	3.12421720
120	positive regulation of ligase activity (GO:0051351)	3.10066089
121	pyrimidine nucleotide catabolic process (GO:0006244)	3.08479447
122	establishment of viral latency (GO:0019043)	3.08362662
123	aldehyde catabolic process (GO:0046185)	3.08138574
124	telomere maintenance via telomere lengthening (GO:0010833)	3.07207137
125	viral mRNA export from host cell nucleus (GO:0046784)	3.01997039
126	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.96639184
127	protein-cofactor linkage (GO:0018065)	2.93028407
128	DNA damage response, detection of DNA damage (GO:0042769)	2.92689145
129	ubiquinone biosynthetic process (GO:0006744)	2.86333358
130	base-excision repair, AP site formation (GO:0006285)	2.83444637
131	UTP biosynthetic process (GO:0006228)	2.79931050
132	protein targeting (GO:0006605)	2.79577232
133	ribonucleoside monophosphate biosynthetic process (GO:0009156)	2.77820931
134	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.77610884

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.74275921
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.33692687
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.26876474
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.19275385
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.01966013
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90093119
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.78011269
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.65577425
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.43892516
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.19432238
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.18997073
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.17212521
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.05136820
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.87226541
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.81124915
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.75630522
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.71574396
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62459496
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.56107136
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.55260060
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.53955341
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.33780823
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.30361982
24	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.25890587
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.24240712
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.23539278
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.21877618
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.21169698
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.17276755
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.08332020
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07660285
32	GABP_19822575_ChIP-Seq_HepG2_Human	2.06753765
33	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.04398149
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.02654744
35	TTF2_22483619_ChIP-Seq_HELA_Human	2.02467616
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.97276145
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.88126166
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.81161655
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80951407
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.78884284
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78695175
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.75032159
43	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72607854
44	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.70708269
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62059609
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.55414323
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.52501400
48	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.52442392
49	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.51306960
50	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.49486533
51	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.48838068
52	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.46983452
53	CIITA_25753668_ChIP-Seq_RAJI_Human	1.46742052
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.46042463
55	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.45823394
56	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.44730615
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.40665475
58	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38332087
59	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36954166
60	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.34677287
61	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.31090649
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.26864856
63	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26482586
64	VDR_22108803_ChIP-Seq_LS180_Human	1.25924903
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.25468971
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24019301
67	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.22729125
68	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21223657
69	SPI1_23547873_ChIP-Seq_NB4_Human	1.20800355
70	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.17200287
71	EWS_26573619_Chip-Seq_HEK293_Human	1.15416926
72	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15361362
73	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.15233740
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13618932
75	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.11672702
76	FUS_26573619_Chip-Seq_HEK293_Human	1.11192602
77	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09803997
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08022449
79	KDM5A_27292631_Chip-Seq_BREAST_Human	1.07938395
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06962485
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.06843332
82	VDR_21846776_ChIP-Seq_THP-1_Human	1.06560766
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.05204639
84	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.04477809
85	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.03335295
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01972649
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.01971152
88	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.00594827
89	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00382794
90	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99310723
91	AR_21909140_ChIP-Seq_LNCAP_Human	0.99231719
92	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.98899146
93	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.97226865
94	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.95703958
95	TFEB_21752829_ChIP-Seq_HELA_Human	0.95010088
96	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.94634818
97	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.93851628
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.92881828
99	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.92685371
100	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.92225863
101	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.90115238
102	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89380614
103	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.88528593
104	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87474397
105	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.87447114
106	MYC_22102868_ChIP-Seq_BL_Human	0.87444953
107	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87418391
108	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.86393189
109	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.86108527
110	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.85274380
111	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.85199596
112	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83711194
113	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.82512459
114	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.80987174
115	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.80410287
116	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.80340289
117	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.80287626
118	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.79719278
119	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.79704686
120	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.77064145
121	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.76635094
122	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.76524581
123	IGF1R_20145208_ChIP-Seq_DFB_Human	0.73260784
124	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.71412986
125	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.70737553
126	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.68380648
127	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.66579033
128	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.65024969
129	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.65009440

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.44433889
2	MP0009379_abnormal_foot_pigmentation	3.78850429
3	MP0004957_abnormal_blastocyst_morpholog	3.53360343
4	MP0003186_abnormal_redox_activity	2.99830822
5	MP0003077_abnormal_cell_cycle	2.97971299
6	MP0010094_abnormal_chromosome_stability	2.83204164
7	MP0002837_dystrophic_cardiac_calcinosis	2.80126220
8	MP0008058_abnormal_DNA_repair	2.70335173
9	MP0003111_abnormal_nucleus_morphology	2.51923507
10	MP0004145_abnormal_muscle_electrophysio	2.48100415
11	MP0006036_abnormal_mitochondrial_physio	2.46691360
12	MP0003806_abnormal_nucleotide_metabolis	2.44933536
13	MP0002396_abnormal_hematopoietic_system	2.44260726
14	MP0001835_abnormal_antigen_presentation	2.43951618
15	MP0009333_abnormal_splenocyte_physiolog	2.43662378
16	MP0008007_abnormal_cellular_replicative	2.41873950
17	MP0008932_abnormal_embryonic_tissue	2.18161243
18	MP0002132_abnormal_respiratory_system	2.15838532
19	MP0003787_abnormal_imprinting	2.12063252
20	MP0008057_abnormal_DNA_replication	2.03527469
21	MP0006072_abnormal_retinal_apoptosis	1.99854635
22	MP0003136_yellow_coat_color	1.98300167
23	MP0000490_abnormal_crypts_of	1.96293071
24	MP0002148_abnormal_hypersensitivity_rea	1.90466247
25	MP0006292_abnormal_olfactory_placode	1.90347001
26	MP0003786_premature_aging	1.83879571
27	MP0009785_altered_susceptibility_to	1.83822254
28	MP0005671_abnormal_response_to	1.76927318
29	MP0006035_abnormal_mitochondrial_morpho	1.75827049
30	MP0003718_maternal_effect	1.74940526
31	MP0003646_muscle_fatigue	1.71138810
32	MP0001853_heart_inflammation	1.70879734
33	MP0001529_abnormal_vocalization	1.69876963
34	MP0003763_abnormal_thymus_physiology	1.65541575
35	MP0002736_abnormal_nociception_after	1.63872128
36	MP0002638_abnormal_pupillary_reflex	1.61809527
37	MP0001293_anophthalmia	1.60871176
38	MP0003121_genomic_imprinting	1.58637738
39	MP0005075_abnormal_melanosome_morpholog	1.58062465
40	MP0003724_increased_susceptibility_to	1.56912573
41	MP0002398_abnormal_bone_marrow	1.52029544
42	MP0001984_abnormal_olfaction	1.51653204
43	MP0000685_abnormal_immune_system	1.49697595
44	MP0002653_abnormal_ependyma_morphology	1.48304695
45	MP0006276_abnormal_autonomic_nervous	1.47982163
46	MP0003656_abnormal_erythrocyte_physiolo	1.45254154
47	MP0005025_abnormal_response_to	1.44211081
48	MP0001986_abnormal_taste_sensitivity	1.43493443
49	MP0003436_decreased_susceptibility_to	1.42509494
50	MP0004147_increased_porphyrin_level	1.42434678
51	MP0005394_taste/olfaction_phenotype	1.41911269
52	MP0005499_abnormal_olfactory_system	1.41911269
53	MP0001968_abnormal_touch/_nociception	1.40783788
54	MP0000689_abnormal_spleen_morphology	1.40428510
55	MP0001800_abnormal_humoral_immune	1.39944495
56	MP0005000_abnormal_immune_tolerance	1.37681355
57	MP0010030_abnormal_orbit_morphology	1.37050862
58	MP0000313_abnormal_cell_death	1.37023076
59	MP0002722_abnormal_immune_system	1.36853468
60	MP0003123_paternal_imprinting	1.34613530
61	MP0002420_abnormal_adaptive_immunity	1.34144197
62	MP0005551_abnormal_eye_electrophysiolog	1.34129593
63	MP0002429_abnormal_blood_cell	1.32455829
64	MP0002723_abnormal_immune_serum	1.32171569
65	MP0001819_abnormal_immune_cell	1.32131010
66	MP0006054_spinal_hemorrhage	1.31335664
67	MP0002234_abnormal_pharynx_morphology	1.31051679
68	MP0005084_abnormal_gallbladder_morpholo	1.31023756
69	MP0003941_abnormal_skin_development	1.30784631
70	MP0002452_abnormal_antigen_presenting	1.29842584
71	MP0009046_muscle_twitch	1.28976641
72	MP0000716_abnormal_immune_system	1.28366417
73	MP0001545_abnormal_hematopoietic_system	1.26250622
74	MP0005397_hematopoietic_system_phenotyp	1.26250622
75	MP0003122_maternal_imprinting	1.25925682
76	MP0002019_abnormal_tumor_incidence	1.25513746
77	MP0004215_abnormal_myocardial_fiber	1.25256907
78	MP0003880_abnormal_central_pattern	1.21844620
79	MP0005645_abnormal_hypothalamus_physiol	1.21768751
80	MP0004142_abnormal_muscle_tone	1.20896387
81	MP0005253_abnormal_eye_physiology	1.19624262
82	MP0001764_abnormal_homeostasis	1.18838739
83	MP0000350_abnormal_cell_proliferation	1.18741022
84	MP0002272_abnormal_nervous_system	1.17063422
85	MP0000358_abnormal_cell_content/	1.16883535
86	MP0000631_abnormal_neuroendocrine_gland	1.14204160
87	MP0002405_respiratory_system_inflammati	1.13386329
88	MP0003137_abnormal_impulse_conducting	1.12390824
89	MP0001730_embryonic_growth_arrest	1.12013119
90	MP0005646_abnormal_pituitary_gland	1.10488214
91	MP0004133_heterotaxia	1.08662486
92	MP0005174_abnormal_tail_pigmentation	1.08488481
93	MP0008995_early_reproductive_senescence	1.08062308
94	MP0005379_endocrine/exocrine_gland_phen	1.07178616
95	MP0000703_abnormal_thymus_morphology	1.05828804
96	MP0002822_catalepsy	1.05620231
97	MP0004808_abnormal_hematopoietic_stem	1.05177286
98	MP0001188_hyperpigmentation	1.04934010
99	MP0002419_abnormal_innate_immunity	1.04518948
100	MP0001905_abnormal_dopamine_level	1.02848311
101	MP0000343_altered_response_to	1.02230698
102	MP0005332_abnormal_amino_acid	1.01551041
103	MP0000372_irregular_coat_pigmentation	0.99090178
104	MP0002734_abnormal_mechanical_nocicepti	0.99087796
105	MP0008469_abnormal_protein_level	0.97200813
106	MP0003283_abnormal_digestive_organ	0.96545296
107	MP0002160_abnormal_reproductive_system	0.94720439
108	MP0001485_abnormal_pinna_reflex	0.94297457
109	MP0002095_abnormal_skin_pigmentation	0.93185956
110	MP0009745_abnormal_behavioral_response	0.91398804
111	MP0001790_abnormal_immune_system	0.90325539
112	MP0005387_immune_system_phenotype	0.90325539
113	MP0002102_abnormal_ear_morphology	0.89569345
114	MP0002210_abnormal_sex_determination	0.87596033
115	MP0000858_altered_metastatic_potential	0.86382896
116	MP0005266_abnormal_metabolism	0.85815186
117	MP0002277_abnormal_respiratory_mucosa	0.85034938
118	MP0003567_abnormal_fetal_cardiomyocyte	0.84410566
119	MP0008877_abnormal_DNA_methylation	0.84027300
120	MP0002233_abnormal_nose_morphology	0.83113564
121	MP0001845_abnormal_inflammatory_respons	0.82715551
122	MP0002090_abnormal_vision	0.82077929
123	MP0002163_abnormal_gland_morphology	0.82044414
124	MP0005408_hypopigmentation	0.81804373
125	MP0001697_abnormal_embryo_size	0.81763555
126	MP0001727_abnormal_embryo_implantation	0.81620677
127	MP0002735_abnormal_chemical_nociception	0.81248723
128	MP0002080_prenatal_lethality	0.81175061
129	MP0003315_abnormal_perineum_morphology	0.80521069
130	MP0009697_abnormal_copulation	0.79400098
131	MP0003011_delayed_dark_adaptation	0.79113239
132	MP0008872_abnormal_physiological_respon	0.77617733
133	MP0003937_abnormal_limbs/digits/tail_de	0.77090742
134	MP0000749_muscle_degeneration	0.75988602
135	MP0005389_reproductive_system_phenotype	0.75684798
136	MP0005636_abnormal_mineral_homeostasis	0.75551804
137	MP0001145_abnormal_male_reproductive	0.74929788
138	MP0002876_abnormal_thyroid_physiology	0.74921242
139	MP0001486_abnormal_startle_reflex	0.74892197
140	MP0003221_abnormal_cardiomyocyte_apopto	0.74196689
141	MP0005670_abnormal_white_adipose	0.74060038
142	MP0005195_abnormal_posterior_eye	0.73778066
143	MP0001929_abnormal_gametogenesis	0.73774595
144	MP0000653_abnormal_sex_gland	0.73186917
145	MP0000465_gastrointestinal_hemorrhage	0.71997475
146	MP0000015_abnormal_ear_pigmentation	0.71669228
147	MP0000049_abnormal_middle_ear	0.71327446
148	MP0001970_abnormal_pain_threshold	0.70951061
149	MP0010155_abnormal_intestine_physiology	0.70330632
150	MP0002938_white_spotting	0.69991826
151	MP0002733_abnormal_thermal_nociception	0.69974243
152	MP0002752_abnormal_somatic_nervous	0.68782262
153	MP0008775_abnormal_heart_ventricle	0.68582855
154	MP0005376_homeostasis/metabolism_phenot	0.68468690
155	MP0000026_abnormal_inner_ear	0.67534064
156	MP0008875_abnormal_xenobiotic_pharmacok	0.67327514
157	MP0005464_abnormal_platelet_physiology	0.66436953
158	MP0008789_abnormal_olfactory_epithelium	0.65723009
159	MP0001663_abnormal_digestive_system	0.63543042
160	MP0010368_abnormal_lymphatic_system	0.61785065

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.61760841
2	Abnormal number of erythroid precursors (HP:0012131)	5.45417280
3	Mitochondrial inheritance (HP:0001427)	4.97192140
4	Hepatocellular necrosis (HP:0001404)	4.97083857
5	Acute necrotizing encephalopathy (HP:0006965)	4.96580358
6	Reticulocytopenia (HP:0001896)	4.85254764
7	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.74281099
8	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.74281099
9	Abnormal mitochondria in muscle tissue (HP:0008316)	4.67080132
10	Increased hepatocellular lipid droplets (HP:0006565)	4.58155448
11	Increased CSF lactate (HP:0002490)	4.56264295
12	Hepatic necrosis (HP:0002605)	4.54257617
13	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.27244875
14	Lipid accumulation in hepatocytes (HP:0006561)	4.21839184
15	Acute encephalopathy (HP:0006846)	4.15586563
16	Macrocytic anemia (HP:0001972)	3.92378130
17	3-Methylglutaconic aciduria (HP:0003535)	3.89965586
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.83926297
19	Progressive macrocephaly (HP:0004481)	3.83022462
20	Increased serum lactate (HP:0002151)	3.79479744
21	Aplastic anemia (HP:0001915)	3.66013324
22	Increased intramyocellular lipid droplets (HP:0012240)	3.63480459
23	Increased serum pyruvate (HP:0003542)	3.62345732
24	Abnormality of glycolysis (HP:0004366)	3.62345732
25	Exertional dyspnea (HP:0002875)	3.62004555
26	Renal Fanconi syndrome (HP:0001994)	3.60862015
27	Pallor (HP:0000980)	3.52314040
28	Birth length less than 3rd percentile (HP:0003561)	3.34230153
29	Lactic acidosis (HP:0003128)	3.31684672
30	Increased muscle lipid content (HP:0009058)	3.21907085
31	Type I transferrin isoform profile (HP:0003642)	3.17765559
32	Respiratory failure (HP:0002878)	3.16625376
33	Respiratory difficulties (HP:0002880)	3.16374618
34	Exercise intolerance (HP:0003546)	3.15049442
35	Microvesicular hepatic steatosis (HP:0001414)	3.03520283
36	Abnormality of the anterior horn cell (HP:0006802)	2.94064436
37	Degeneration of anterior horn cells (HP:0002398)	2.94064436
38	Cerebral edema (HP:0002181)	2.93933443
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.81132684
40	Oral leukoplakia (HP:0002745)	2.78607496
41	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.75564378
42	Pancreatic fibrosis (HP:0100732)	2.65899289
43	Reduced antithrombin III activity (HP:0001976)	2.64049718
44	Hyperglycinemia (HP:0002154)	2.56702357
45	Petechiae (HP:0000967)	2.51408450
46	Cerebral hypomyelination (HP:0006808)	2.47504931
47	Poor head control (HP:0002421)	2.45699055
48	Breast hypoplasia (HP:0003187)	2.44785516
49	Pancreatic cysts (HP:0001737)	2.41823786
50	Thrombocytosis (HP:0001894)	2.37693733
51	Rough bone trabeculation (HP:0100670)	2.36854589
52	CNS demyelination (HP:0007305)	2.33764661
53	Optic disc pallor (HP:0000543)	2.28688425
54	Carpal bone hypoplasia (HP:0001498)	2.28260572
55	Leukodystrophy (HP:0002415)	2.28217448
56	Pancytopenia (HP:0001876)	2.28018947
57	Microretrognathia (HP:0000308)	2.27006355
58	Congenital, generalized hypertrichosis (HP:0004540)	2.26693722
59	True hermaphroditism (HP:0010459)	2.26542972
60	Myokymia (HP:0002411)	2.24249544
61	Muscle fiber atrophy (HP:0100295)	2.23362771
62	Methylmalonic acidemia (HP:0002912)	2.21482206
63	Type 2 muscle fiber atrophy (HP:0003554)	2.18888472
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17636109
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.17636109
66	Abnormal protein glycosylation (HP:0012346)	2.17636109
67	Abnormal glycosylation (HP:0012345)	2.17636109
68	Medial flaring of the eyebrow (HP:0010747)	2.16184726
69	Emotional lability (HP:0000712)	2.16178600
70	Abnormality of alanine metabolism (HP:0010916)	2.15926967
71	Hyperalaninemia (HP:0003348)	2.15926967
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.15926967
73	IgM deficiency (HP:0002850)	2.15580782
74	Abnormality of midbrain morphology (HP:0002418)	2.11992370
75	Molar tooth sign on MRI (HP:0002419)	2.11992370
76	Multiple enchondromatosis (HP:0005701)	2.10957652
77	Hyperglycinuria (HP:0003108)	2.07707910
78	11 pairs of ribs (HP:0000878)	2.07633290
79	Sclerocornea (HP:0000647)	2.02845358
80	Abnormality of the labia minora (HP:0012880)	2.02688188
81	Elevated erythrocyte sedimentation rate (HP:0003565)	2.02145956
82	Septo-optic dysplasia (HP:0100842)	2.01677670
83	Hypoglycemic coma (HP:0001325)	2.01179190
84	Abnormality of renal resorption (HP:0011038)	1.99132910
85	Trismus (HP:0000211)	1.96896537
86	X-linked dominant inheritance (HP:0001423)	1.94443705
87	Nephronophthisis (HP:0000090)	1.93570588
88	Lethargy (HP:0001254)	1.91736131
89	Hyperinsulinemic hypoglycemia (HP:0000825)	1.91343751
90	Gliosis (HP:0002171)	1.90867090
91	Recurrent abscess formation (HP:0002722)	1.86412679
92	Abnormality of reticulocytes (HP:0004312)	1.85069885
93	Colon cancer (HP:0003003)	1.84436159
94	Abnormality of serum amino acid levels (HP:0003112)	1.83837781
95	Secondary amenorrhea (HP:0000869)	1.82373956
96	Premature graying of hair (HP:0002216)	1.82254606
97	Ragged-red muscle fibers (HP:0003200)	1.82097954
98	Abnormality of glycine metabolism (HP:0010895)	1.81151982
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81151982
100	Dicarboxylic aciduria (HP:0003215)	1.80426350
101	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80426350
102	Hyperphosphaturia (HP:0003109)	1.79021342
103	Esophageal neoplasm (HP:0100751)	1.78783207
104	Neoplasm of head and neck (HP:0012288)	1.78783207
105	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77541032
106	Nemaline bodies (HP:0003798)	1.75809691
107	Gait imbalance (HP:0002141)	1.74434356
108	Congenital primary aphakia (HP:0007707)	1.73244198
109	Glycosuria (HP:0003076)	1.72576422
110	Abnormality of urine glucose concentration (HP:0011016)	1.72576422
111	Cleft eyelid (HP:0000625)	1.69377792
112	Abnormal trabecular bone morphology (HP:0100671)	1.69324570
113	Maternal diabetes (HP:0009800)	1.69264894
114	Muscle fiber inclusion bodies (HP:0100299)	1.68417774
115	Blindness (HP:0000618)	1.67933610
116	Absent thumb (HP:0009777)	1.67207068
117	Nausea (HP:0002018)	1.66050919
118	Poor suck (HP:0002033)	1.65647259
119	Generalized aminoaciduria (HP:0002909)	1.64335123
120	Agnosia (HP:0010524)	1.64176202
121	Bone marrow hypocellularity (HP:0005528)	1.63838167
122	Sparse eyelashes (HP:0000653)	1.63109704
123	Vomiting (HP:0002013)	1.62900149
124	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.61824649
125	Nephrogenic diabetes insipidus (HP:0009806)	1.61027672
126	Recurrent bacterial skin infections (HP:0005406)	1.60002643
127	Progressive muscle weakness (HP:0003323)	1.59430660
128	Increased serum ferritin (HP:0003281)	1.59367196
129	Neutropenia (HP:0001875)	1.57716447
130	Anencephaly (HP:0002323)	1.57542011
131	Hypoglycemic seizures (HP:0002173)	1.55998800
132	Rib fusion (HP:0000902)	1.55814096
133	Methylmalonic aciduria (HP:0012120)	1.55119538
134	Cellular immunodeficiency (HP:0005374)	1.54172634
135	Tongue fasciculations (HP:0001308)	1.53888498

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.61015214
2	NME2	4.72945818
3	BUB1	4.66657448
4	STK16	3.74335114
5	TLK1	3.30096906
6	EIF2AK1	3.16286001
7	WEE1	3.04420694
8	PIM2	2.63272233
9	VRK1	2.48214523
10	EIF2AK3	2.18974732
11	TESK2	2.14740423
12	NUAK1	2.11020747
13	BMPR1B	2.01812067
14	SRPK1	2.00221751
15	WNK3	1.97613271
16	OBSCN	1.86172290
17	BCKDK	1.79422176
18	DYRK3	1.77066792
19	TAF1	1.76701783
20	NME1	1.75890235
21	CDC7	1.67981800
22	KDR	1.64004806
23	ARAF	1.55299379
24	CDK19	1.49092398
25	PHKG1	1.47801769
26	PHKG2	1.47801769
27	MAP4K2	1.45423942
28	CSNK1G3	1.43406316
29	IRAK4	1.40008697
30	PLK4	1.38378845
31	CSNK1G2	1.36851638
32	PASK	1.34277102
33	CSNK1G1	1.32678083
34	BRSK2	1.32229987
35	CDK8	1.24767392
36	MAP4K1	1.24749075
37	MKNK1	1.24673829
38	BLK	1.21484007
39	CDK7	1.20872532
40	MAP3K11	1.19586017
41	INSRR	1.19068539
42	PBK	1.18299657
43	TTK	1.16975961
44	TSSK6	1.16051984
45	GRK1	1.13865595
46	MAP3K12	1.12234411
47	RPS6KA4	1.11799015
48	SCYL2	1.11419279
49	TEC	1.10905875
50	PAK4	1.06033406
51	MST4	1.06008264
52	PINK1	1.05551433
53	KIT	1.05182162
54	CCNB1	1.04690101
55	MAP2K7	1.03921903
56	BTK	1.02864906
57	BRAF	1.02401005
58	PLK1	1.02346566
59	PDK2	1.02122328
60	ADRBK2	0.99932109
61	ABL2	0.98384510
62	TESK1	0.96741365
63	AURKA	0.93503926
64	AURKB	0.92553450
65	LIMK1	0.92496316
66	TBK1	0.92328887
67	ILK	0.91672272
68	CSNK1A1L	0.84955220
69	TIE1	0.83804023
70	IRAK3	0.83725770
71	ZAP70	0.82552713
72	MAP3K4	0.82407103
73	PIM1	0.80256804
74	FLT3	0.80220377
75	CSNK2A1	0.79544827
76	SYK	0.79189751
77	ATR	0.78894221
78	GRK7	0.77416552
79	BRSK1	0.76079776
80	ACVR1B	0.75430156
81	OXSR1	0.74090937
82	MYLK	0.73946769
83	MKNK2	0.72759629
84	TXK	0.72669571
85	RPS6KB2	0.71926492
86	CAMKK2	0.70813455
87	PRKCG	0.69818374
88	TYK2	0.68937886
89	CSNK2A2	0.68855046
90	DYRK2	0.68729314
91	ZAK	0.66994452
92	GRK6	0.66829969
93	LRRK2	0.66202086
94	PAK1	0.66159953
95	NEK1	0.64516879
96	EIF2AK2	0.64385370
97	LYN	0.63678701
98	IKBKB	0.63401768
99	RPS6KA5	0.63006582
100	TNIK	0.61375831
101	MAP2K3	0.60809049
102	RAF1	0.58588206
103	MAPK13	0.57508050
104	MOS	0.57067102
105	MUSK	0.56964654
106	CSF1R	0.56174884
107	FRK	0.55373751
108	TGFBR1	0.55339594
109	IKBKE	0.53618102
110	GRK5	0.52835498
111	CSNK1E	0.50512982
112	CLK1	0.49909851
113	PLK2	0.49869989
114	DAPK3	0.49112273
115	MAP3K8	0.48277511
116	STK24	0.48244710
117	CHEK2	0.46964925
118	TAOK2	0.46754136
119	SIK3	0.46310765
120	CSNK1A1	0.46255820
121	MAPKAPK5	0.44322556
122	PRKCI	0.44226110
123	NLK	0.43996639
124	STK4	0.43866543
125	DAPK1	0.43825680
126	NEK2	0.43714838
127	PRKACA	0.43380295
128	PLK3	0.43328614
129	RPS6KA6	0.42439271
130	CAMK2A	0.41834028
131	CDK4	0.40836009
132	CASK	0.39087054
133	ADRBK1	0.38517617
134	CAMK2D	0.37065881
135	PRKCE	0.36539616
136	WNK4	0.35892015
137	ATM	0.35520678
138	PIK3CG	0.33731994
139	CAMK2G	0.32094456

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.56728954
2	Proteasome_Homo sapiens_hsa03050	4.43400170
3	DNA replication_Homo sapiens_hsa03030	3.95609868
4	RNA polymerase_Homo sapiens_hsa03020	3.46762766
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23252222
6	Parkinsons disease_Homo sapiens_hsa05012	3.02209197
7	Mismatch repair_Homo sapiens_hsa03430	2.99705108
8	Spliceosome_Homo sapiens_hsa03040	2.73514067
9	Pyrimidine metabolism_Homo sapiens_hsa00240	2.62757099
10	Protein export_Homo sapiens_hsa03060	2.59500495
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49146619
12	Base excision repair_Homo sapiens_hsa03410	2.44846422
13	Homologous recombination_Homo sapiens_hsa03440	2.43361933
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.31457186
15	Huntingtons disease_Homo sapiens_hsa05016	2.24114887
16	Alzheimers disease_Homo sapiens_hsa05010	1.92248521
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87336631
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.86392477
19	RNA transport_Homo sapiens_hsa03013	1.83065697
20	Folate biosynthesis_Homo sapiens_hsa00790	1.50834550
21	RNA degradation_Homo sapiens_hsa03018	1.47907245
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45665308
23	Basal transcription factors_Homo sapiens_hsa03022	1.45533298
24	One carbon pool by folate_Homo sapiens_hsa00670	1.42986237
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42504605
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.37307816
27	Purine metabolism_Homo sapiens_hsa00230	1.35818316
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32155464
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.31989129
30	Sulfur relay system_Homo sapiens_hsa04122	1.26848124
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26455583
32	Cell cycle_Homo sapiens_hsa04110	1.20265363
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.10734083
34	Sulfur metabolism_Homo sapiens_hsa00920	1.01772732
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99111417
36	Glutathione metabolism_Homo sapiens_hsa00480	0.98946484
37	Butanoate metabolism_Homo sapiens_hsa00650	0.97295664
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.96563564
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84150139
40	Phototransduction_Homo sapiens_hsa04744	0.83998385
41	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83105891
42	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.82780130
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80884952
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.75185094
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71959574
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70559371
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.70018507
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.69981538
49	Pentose phosphate pathway_Homo sapiens_hsa00030	0.68411771
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67244662
51	Carbon metabolism_Homo sapiens_hsa01200	0.67069652
52	Metabolic pathways_Homo sapiens_hsa01100	0.66730169
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66431719
54	p53 signaling pathway_Homo sapiens_hsa04115	0.66173391
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.65905609
56	Fatty acid degradation_Homo sapiens_hsa00071	0.64799325
57	Herpes simplex infection_Homo sapiens_hsa05168	0.63827009
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63673869
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63027974
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.61957745
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61436387
62	Legionellosis_Homo sapiens_hsa05134	0.60233670
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59527679
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.58143335
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56541386
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54830335
67	Nicotine addiction_Homo sapiens_hsa05033	0.50917957
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50699402
69	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48824239
70	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.47120226
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45869488
72	Allograft rejection_Homo sapiens_hsa05330	0.43157002
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.43144835
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41969520
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41238941
76	Fatty acid elongation_Homo sapiens_hsa00062	0.40672086
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39357085
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38245931
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37688416
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36063848
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35939587
82	Peroxisome_Homo sapiens_hsa04146	0.35916690
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35727006
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.34958952
85	Propanoate metabolism_Homo sapiens_hsa00640	0.34621800
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34605646
87	Shigellosis_Homo sapiens_hsa05131	0.34514134
88	Asthma_Homo sapiens_hsa05310	0.34337930
89	Graft-versus-host disease_Homo sapiens_hsa05332	0.34228361
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33755899
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33578691
92	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.32574240
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.32203568
94	Leishmaniasis_Homo sapiens_hsa05140	0.31589544
95	Measles_Homo sapiens_hsa05162	0.30233411
96	Galactose metabolism_Homo sapiens_hsa00052	0.27520347
97	Regulation of autophagy_Homo sapiens_hsa04140	0.26134631
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.25995584
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.25873265
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25430127
101	Other glycan degradation_Homo sapiens_hsa00511	0.25064366
102	Alcoholism_Homo sapiens_hsa05034	0.24999288
103	Retinol metabolism_Homo sapiens_hsa00830	0.24928173
104	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24750298
105	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.24562250
106	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.24153279
107	Phenylalanine metabolism_Homo sapiens_hsa00360	0.23775466
108	Pertussis_Homo sapiens_hsa05133	0.23628095
109	Basal cell carcinoma_Homo sapiens_hsa05217	0.22483241
110	Thyroid cancer_Homo sapiens_hsa05216	0.22396144
111	Oocyte meiosis_Homo sapiens_hsa04114	0.21147955
112	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20868366
113	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.20151837
114	Fat digestion and absorption_Homo sapiens_hsa04975	0.19789033
115	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.19751476
116	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.19515260
117	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.18918341
118	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.18385301
119	Tyrosine metabolism_Homo sapiens_hsa00350	0.17813383
120	Viral carcinogenesis_Homo sapiens_hsa05203	0.17082537
121	Arginine biosynthesis_Homo sapiens_hsa00220	0.16639623
122	Apoptosis_Homo sapiens_hsa04210	0.14418733
123	Vibrio cholerae infection_Homo sapiens_hsa05110	0.14296504
124	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.14181861
125	Chemical carcinogenesis_Homo sapiens_hsa05204	0.11711209
126	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.11421497
127	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.11163345
128	Rheumatoid arthritis_Homo sapiens_hsa05323	0.11010876
129	beta-Alanine metabolism_Homo sapiens_hsa00410	0.10827155
130	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.10686313
131	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.10648824

TMEM261

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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