TMEM262

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)5.34171673
2ribosomal small subunit biogenesis (GO:0042274)5.01317146
3regulation of chemokine secretion (GO:0090196)4.55711571
4oligosaccharide catabolic process (GO:0009313)4.31755206
5viral transcription (GO:0019083)4.03619355
6interferon-gamma secretion (GO:0072643)4.01837880
7positive regulation of gamma-delta T cell activation (GO:0046645)3.97628905
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.84167687
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78416777
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.78416777
11modulation by symbiont of host immune response (GO:0052553)3.78416777
12positive regulation by symbiont of host defense response (GO:0052509)3.78416777
13modulation by symbiont of host defense response (GO:0052031)3.78416777
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78416777
15response to protozoan (GO:0001562)3.77567939
16T-helper 1 type immune response (GO:0042088)3.77347102
17regulation of interferon-beta biosynthetic process (GO:0045357)3.76442491
18translational termination (GO:0006415)3.75390054
19NIK/NF-kappaB signaling (GO:0038061)3.54790711
20response to host immune response (GO:0052572)3.45037333
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45037333
22response to type I interferon (GO:0034340)3.37492845
23response to peptidoglycan (GO:0032494)3.33847671
24amino sugar catabolic process (GO:0046348)3.31556355
25response to host (GO:0075136)3.31333995
26response to host defenses (GO:0052200)3.31333995
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31333995
28negative regulation of T cell mediated immunity (GO:0002710)3.27307105
29type I interferon signaling pathway (GO:0060337)3.27135694
30cellular response to type I interferon (GO:0071357)3.27135694
31tolerance induction (GO:0002507)3.26277326
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20061761
33negative regulation of cell killing (GO:0031342)3.20061761
34viral life cycle (GO:0019058)3.19813048
35translational elongation (GO:0006414)3.19312202
36regulation of T-helper 1 type immune response (GO:0002825)3.14151565
37defense response to protozoan (GO:0042832)3.13937434
38regulation of B cell receptor signaling pathway (GO:0050855)3.13773487
39negative regulation of interleukin-12 production (GO:0032695)3.13647641
40cotranslational protein targeting to membrane (GO:0006613)3.11523470
41macrophage activation involved in immune response (GO:0002281)3.11443452
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11335066
43ncRNA 3-end processing (GO:0043628)3.11252499
44negative regulation of interleukin-6 production (GO:0032715)3.10123299
45protein targeting to ER (GO:0045047)3.09355018
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09348393
47leukocyte aggregation (GO:0070486)3.09323637
48protein-cofactor linkage (GO:0018065)3.08345026
49regulation of B cell differentiation (GO:0045577)3.06939676
50production of molecular mediator involved in inflammatory response (GO:0002532)3.05951129
51negative regulation of macrophage differentiation (GO:0045650)3.04624104
52cellular response to exogenous dsRNA (GO:0071360)3.00421680
53response to interferon-alpha (GO:0035455)2.96785162
54response to interferon-beta (GO:0035456)2.95080369
55respiratory burst (GO:0045730)2.94526939
56lymphocyte chemotaxis (GO:0048247)2.93480511
57negative regulation of viral genome replication (GO:0045071)2.92199976
58immunoglobulin mediated immune response (GO:0016064)2.90114438
59protein localization to endoplasmic reticulum (GO:0070972)2.89647965
60neutrophil activation involved in immune response (GO:0002283)2.88244469
61establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87073403
62cellular protein complex disassembly (GO:0043624)2.86520073
63negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82177420
64regulation of mast cell degranulation (GO:0043304)2.81903825
65CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77743107
66regulation of gamma-delta T cell activation (GO:0046643)2.74126479
67negative regulation of adaptive immune response (GO:0002820)2.73882383
68detection of other organism (GO:0098543)2.72732851
69regulation of interferon-gamma biosynthetic process (GO:0045072)2.72524958
70cellular response to virus (GO:0098586)2.72432588
71granulocyte activation (GO:0036230)2.72209499
72negative regulation of interferon-gamma production (GO:0032689)2.69916443
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69862367
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67971705
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.67779238
76myeloid cell activation involved in immune response (GO:0002275)2.65966156
77regulation of interleukin-5 production (GO:0032674)2.65889761
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64901806
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62391123
80positive thymic T cell selection (GO:0045059)2.61694630
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.61477631
82regulation of defense response to virus by host (GO:0050691)2.61320245
83leukocyte degranulation (GO:0043299)2.60956879
84detection of bacterium (GO:0016045)2.60897828
85antigen processing and presentation of endogenous antigen (GO:0019883)2.60703123
86negative regulation of cytokine production involved in immune response (GO:0002719)2.60673854
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60672983
88macrophage activation (GO:0042116)2.57086502
89positive regulation of type 2 immune response (GO:0002830)2.55209841
90N-acetylneuraminate metabolic process (GO:0006054)2.54713551
91positive regulation of defense response to virus by host (GO:0002230)2.54608523
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53936127
93regulation of mast cell activation (GO:0033003)2.52694049
94DNA deamination (GO:0045006)2.52614464
95cellular response to interleukin-4 (GO:0071353)2.51024511
96positive regulation of macrophage activation (GO:0043032)2.50727796
97GDP-mannose metabolic process (GO:0019673)2.50673207
98ribonucleoprotein complex biogenesis (GO:0022613)2.50175256
99positive regulation of B cell differentiation (GO:0045579)2.49435372
100response to muramyl dipeptide (GO:0032495)2.49407750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.14434644
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.72363171
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49854391
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38257332
5VDR_21846776_ChIP-Seq_THP-1_Human2.78203597
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42883150
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37118257
8VDR_24763502_ChIP-Seq_THP-1_Human2.28701952
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.24205445
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23515478
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19765227
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13107092
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12336080
14MAF_26560356_Chip-Seq_TH2_Human2.11127233
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10543421
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03525887
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00560240
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99876517
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.98782559
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98278170
21MAF_26560356_Chip-Seq_TH1_Human1.96022149
22SPI1_23547873_ChIP-Seq_NB4_Human1.93552392
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.90037174
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.87225862
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86664879
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83633296
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82690903
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81183068
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80316940
30SCL_19346495_ChIP-Seq_HPC-7_Human1.79833099
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79145592
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78628296
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75773058
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75372779
35ZNF263_19887448_ChIP-Seq_K562_Human1.75151814
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75096980
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74719024
38VDR_23849224_ChIP-Seq_CD4+_Human1.74571218
39MYC_22102868_ChIP-Seq_BL_Human1.71579809
40UTX_26944678_Chip-Seq_JUKART_Human1.66698691
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59909480
42XRN2_22483619_ChIP-Seq_HELA_Human1.59369330
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54927941
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.52207637
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50497264
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49801863
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.49451683
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48229206
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47722124
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.47336015
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46762516
52CIITA_25753668_ChIP-Seq_RAJI_Human1.45174514
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44006132
54MYB_26560356_Chip-Seq_TH1_Human1.43566193
55MYB_26560356_Chip-Seq_TH2_Human1.42643260
56DCP1A_22483619_ChIP-Seq_HELA_Human1.41377450
57BCL6_27268052_Chip-Seq_Bcells_Human1.40475903
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.39963243
59BCOR_27268052_Chip-Seq_Bcells_Human1.37079505
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35822690
61LXR_22292898_ChIP-Seq_THP-1_Human1.35679123
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33308630
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28198362
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.27519436
65FOXP3_21729870_ChIP-Seq_TREG_Human1.27255810
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.26155594
67KDM2B_26808549_Chip-Seq_DND41_Human1.25898237
68TCF7_22412390_ChIP-Seq_EML_Mouse1.24832525
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.24504123
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23785872
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22229395
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21650644
73RACK7_27058665_Chip-Seq_MCF-7_Human1.20685942
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20337975
75SPI1_23127762_ChIP-Seq_K562_Human1.20129985
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20053941
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20009087
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19953950
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18947748
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18908385
81GABP_19822575_ChIP-Seq_HepG2_Human1.18697744
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16906527
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.16810288
84P68_20966046_ChIP-Seq_HELA_Human1.15981385
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.15034952
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.13856072
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11794800
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11579512
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10836273
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10502582
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09994202
92TTF2_22483619_ChIP-Seq_HELA_Human1.08139566
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07227143
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.05323879
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04327778
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04200780
97RUNX_20019798_ChIP-Seq_JUKART_Human1.03992349
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03814486
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03623566
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.02842862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.14570079
2MP0003436_decreased_susceptibility_to3.44719634
3MP0003724_increased_susceptibility_to3.43672950
4MP0004510_myositis3.38595201
5MP0005671_abnormal_response_to2.89556674
6MP0009785_altered_susceptibility_to2.84597232
7MP0002148_abnormal_hypersensitivity_rea2.84031649
8MP0000685_abnormal_immune_system2.77380322
9MP0005025_abnormal_response_to2.70852063
10MP0001800_abnormal_humoral_immune2.64589342
11MP0002419_abnormal_innate_immunity2.57835948
12MP0002723_abnormal_immune_serum2.57514084
13MP0005387_immune_system_phenotype2.55241973
14MP0001790_abnormal_immune_system2.55241973
15MP0005000_abnormal_immune_tolerance2.46750469
16MP0002452_abnormal_antigen_presenting2.46460239
17MP0003806_abnormal_nucleotide_metabolis2.32404049
18MP0009278_abnormal_bone_marrow2.25887201
19MP0002138_abnormal_hepatobiliary_system2.24418202
20MP0002420_abnormal_adaptive_immunity2.21244500
21MP0005058_abnormal_lysosome_morphology2.21087678
22MP0001819_abnormal_immune_cell2.19269633
23MP0001835_abnormal_antigen_presentation2.13062709
24MP0002132_abnormal_respiratory_system2.02670275
25MP0002405_respiratory_system_inflammati2.02125929
26MP0003191_abnormal_cellular_cholesterol1.96836350
27MP0009333_abnormal_splenocyte_physiolog1.91958429
28MP0002277_abnormal_respiratory_mucosa1.86047999
29MP0005451_abnormal_body_composition1.83872552
30MP0003763_abnormal_thymus_physiology1.80935120
31MP0001845_abnormal_inflammatory_respons1.79997530
32MP0000716_abnormal_immune_system1.78072274
33MP0001533_abnormal_skeleton_physiology1.75658287
34MP0006082_CNS_inflammation1.74219913
35MP0004947_skin_inflammation1.69013123
36MP0005310_abnormal_salivary_gland1.68186347
37MP0002398_abnormal_bone_marrow1.64155965
38MP0008260_abnormal_autophagy1.62946845
39MP0008469_abnormal_protein_level1.49931987
40MP0002429_abnormal_blood_cell1.46862380
41MP0004381_abnormal_hair_follicle1.43144905
42MP0008961_abnormal_basal_metabolism1.39546428
43MP0000689_abnormal_spleen_morphology1.36484201
44MP0003172_abnormal_lysosome_physiology1.34961910
45MP0001853_heart_inflammation1.34703579
46MP0002722_abnormal_immune_system1.34431209
47MP0009764_decreased_sensitivity_to1.32487238
48MP0001873_stomach_inflammation1.31825575
49MP0000858_altered_metastatic_potential1.30475799
50MP0003300_gastrointestinal_ulcer1.28864093
51MP0010155_abnormal_intestine_physiology1.25786587
52MP0005397_hematopoietic_system_phenotyp1.24130416
53MP0001545_abnormal_hematopoietic_system1.24130416
54MP0005076_abnormal_cell_differentiation1.23177649
55MP0002653_abnormal_ependyma_morphology1.22701970
56MP0004808_abnormal_hematopoietic_stem1.21154342
57MP0009765_abnormal_xenobiotic_induced1.17717507
58MP0009763_increased_sensitivity_to1.15112117
59MP0000343_altered_response_to1.15026073
60MP0005084_abnormal_gallbladder_morpholo1.08351179
61MP0003866_abnormal_defecation1.08276876
62MP0002998_abnormal_bone_remodeling1.06731633
63MP0002396_abnormal_hematopoietic_system1.05467718
64MP0005464_abnormal_platelet_physiology1.04404060
65MP0001986_abnormal_taste_sensitivity1.01242584
66MP0001764_abnormal_homeostasis1.00618683
67MP0000703_abnormal_thymus_morphology0.99621038
68MP0001663_abnormal_digestive_system0.98137115
69MP0003315_abnormal_perineum_morphology0.97982200
70MP0003828_pulmonary_edema0.96121903
71MP0003453_abnormal_keratinocyte_physiol0.94270126
72MP0001851_eye_inflammation0.92622568
73MP0005390_skeleton_phenotype0.89608201
74MP0002009_preneoplasia0.89169718
75MP0002928_abnormal_bile_duct0.88221418
76MP0008873_increased_physiological_sensi0.88177503
77MP0005501_abnormal_skin_physiology0.85821091
78MP0009840_abnormal_foam_cell0.83465438
79MP0003136_yellow_coat_color0.79686117
80MP0005164_abnormal_response_to0.77640586
81MP0003656_abnormal_erythrocyte_physiolo0.74832381
82MP0005083_abnormal_biliary_tract0.74758981
83MP0001919_abnormal_reproductive_system0.71278635
84MP0002933_joint_inflammation0.69365745
85MP0003183_abnormal_peptide_metabolism0.68580777
86MP0005166_decreased_susceptibility_to0.66346638
87MP0002877_abnormal_melanocyte_morpholog0.66106320
88MP0002796_impaired_skin_barrier0.65893343
89MP0003075_altered_response_to0.65585974
90MP0003938_abnormal_ear_development0.63535024
91MP0000372_irregular_coat_pigmentation0.62762230
92MP0005381_digestive/alimentary_phenotyp0.62026363
93MP0002019_abnormal_tumor_incidence0.61176010
94MP0004133_heterotaxia0.60998869
95MP0003279_aneurysm0.59830227
96MP0005376_homeostasis/metabolism_phenot0.59105994
97MP0002139_abnormal_hepatobiliary_system0.59059502
98MP0000465_gastrointestinal_hemorrhage0.58991409
99MP0005187_abnormal_penis_morphology0.58933626
100MP0003186_abnormal_redox_activity0.58146258

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.57950636
2Myositis (HP:0100614)4.23831533
3Recurrent abscess formation (HP:0002722)4.17883588
4Abnormality of macrophages (HP:0004311)3.97777329
53-Methylglutaconic aciduria (HP:0003535)3.87636147
6Gastrointestinal infarctions (HP:0005244)3.85326517
7Eczematoid dermatitis (HP:0000976)3.84044156
8Mediastinal lymphadenopathy (HP:0100721)3.72153170
9Orchitis (HP:0100796)3.53162851
10Recurrent fungal infections (HP:0002841)3.47249298
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.44828585
12Pustule (HP:0200039)3.41987789
13Optic neuritis (HP:0100653)3.36063845
14Retrobulbar optic neuritis (HP:0100654)3.36063845
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14193966
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14193966
17Stomatitis (HP:0010280)3.07376366
18Elevated erythrocyte sedimentation rate (HP:0003565)3.04664211
19Aplastic anemia (HP:0001915)3.04575389
20Hypertensive crisis (HP:0100735)2.98320019
21Abnormality of glycolipid metabolism (HP:0010969)2.98137108
22Abnormality of liposaccharide metabolism (HP:0010968)2.98137108
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.98137108
24Abnormality of cells of the erythroid lineage (HP:0012130)2.97086661
25Abnormal number of erythroid precursors (HP:0012131)2.93121098
26Recurrent skin infections (HP:0001581)2.92923015
27Anorexia (HP:0002039)2.90716659
28Obstructive lung disease (HP:0006536)2.79886417
29Chronic obstructive pulmonary disease (HP:0006510)2.79886417
30Encephalitis (HP:0002383)2.77974343
31Recurrent cutaneous fungal infections (HP:0011370)2.76921945
32Chronic mucocutaneous candidiasis (HP:0002728)2.76921945
33Pallor (HP:0000980)2.73631001
34Segmental peripheral demyelination/remyelination (HP:0003481)2.71641713
35Nasolacrimal duct obstruction (HP:0000579)2.67799323
36Meningitis (HP:0001287)2.65105698
37Panhypogammaglobulinemia (HP:0003139)2.64480455
38Abnormality of T cell physiology (HP:0011840)2.58991199
39Abnormality of homocysteine metabolism (HP:0010919)2.46947074
40Homocystinuria (HP:0002156)2.46947074
41Recurrent viral infections (HP:0004429)2.45776408
42Pulmonary infiltrates (HP:0002113)2.42824446
43Respiratory difficulties (HP:0002880)2.42560441
44Increased IgE level (HP:0003212)2.42507790
45Vasculitis (HP:0002633)2.38469261
46Macrocytic anemia (HP:0001972)2.34592215
47Abnormality of the parietal bone (HP:0002696)2.31999286
48Hemoptysis (HP:0002105)2.24699847
49Recurrent gram-negative bacterial infections (HP:0005420)2.24346680
50Keratoconjunctivitis sicca (HP:0001097)2.23500581
51Abnormality of T cells (HP:0002843)2.23422156
52Increased serum ferritin (HP:0003281)2.20034878
53Hepatosplenomegaly (HP:0001433)2.18814475
54Increased intramyocellular lipid droplets (HP:0012240)2.18690865
55Increased muscle lipid content (HP:0009058)2.17512396
56Urticaria (HP:0001025)2.15134814
57Vacuolated lymphocytes (HP:0001922)2.14308331
58Tetany (HP:0001281)2.13028083
59Cheilitis (HP:0100825)2.12388669
60Alopecia of scalp (HP:0002293)2.11463812
61Hypochromic anemia (HP:0001931)2.11400543
62Global brain atrophy (HP:0002283)2.10007887
63Dysostosis multiplex (HP:0000943)2.09638415
64Keratitis (HP:0000491)2.08209097
65Conical tooth (HP:0000698)2.05840903
66Abnormal mitochondria in muscle tissue (HP:0008316)2.03479992
67Concave nail (HP:0001598)2.03082443
68Lymphopenia (HP:0001888)2.01655852
69Stomach cancer (HP:0012126)1.98641760
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97533705
71Methylmalonic aciduria (HP:0012120)1.91903522
72Episodic fever (HP:0001954)1.91765430
73Premature graying of hair (HP:0002216)1.91279231
74Keratoconjunctivitis (HP:0001096)1.90587247
75Gastrointestinal stroma tumor (HP:0100723)1.89326814
76Interstitial pulmonary disease (HP:0006530)1.88659044
77Supernumerary bones of the axial skeleton (HP:0009144)1.86640255
78Gingivitis (HP:0000230)1.85762097
79Oral leukoplakia (HP:0002745)1.85749680
80Chronic otitis media (HP:0000389)1.84640433
81Cellulitis (HP:0100658)1.84352357
82Renal Fanconi syndrome (HP:0001994)1.81693864
83Mitochondrial inheritance (HP:0001427)1.81212741
84Methylmalonic acidemia (HP:0002912)1.79608132
85Type I transferrin isoform profile (HP:0003642)1.78164272
86Abnormality of the pericardium (HP:0001697)1.78003737
87Acute necrotizing encephalopathy (HP:0006965)1.77795611
88Abnormal protein glycosylation (HP:0012346)1.77411258
89Abnormal glycosylation (HP:0012345)1.77411258
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77411258
91Abnormal protein N-linked glycosylation (HP:0012347)1.77411258
92Reticulocytopenia (HP:0001896)1.74826423
93Exertional dyspnea (HP:0002875)1.73162964
94Abnormality of cells of the lymphoid lineage (HP:0012140)1.72836426
95Neuroendocrine neoplasm (HP:0100634)1.71990784
96Agammaglobulinemia (HP:0004432)1.71569064
97Chronic sinusitis (HP:0011109)1.69034193
98Colitis (HP:0002583)1.68349596
99Increased hepatocellular lipid droplets (HP:0006565)1.67491234
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66962141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.88611402
2TESK23.06291064
3TAOK32.87097862
4IRAK42.73839145
5TAOK12.59839568
6MAP2K32.47987615
7ERN12.47575664
8MAP4K12.47107418
9BLK2.27546073
10STK162.16317963
11RIPK42.04278166
12IKBKE1.93293060
13GRK61.91550844
14IKBKB1.91134694
15MAPK151.76807922
16PRKD21.76441013
17PIM21.74371526
18MAP3K111.70448489
19TBK11.68056497
20CDK121.62544031
21CHUK1.62213648
22MAP3K31.61802250
23CLK11.60808356
24ABL21.59237596
25CSK1.58101060
26IRAK31.54549086
27TAOK21.53697587
28MAP3K141.48923164
29MATK1.29142625
30ARAF1.27912826
31SIK21.23264913
32NME21.22126977
33TYK21.14886382
34TXK1.09825027
35EPHA31.08963737
36SIK11.08489524
37BTK1.06424545
38ZAP701.06255882
39TESK11.03316884
40FES1.02294076
41PRPF4B0.95612969
42HCK0.95428370
43SYK0.95192811
44MAP3K130.91178793
45EPHB10.89698680
46RPS6KA60.88571787
47MAP3K10.87757031
48RPS6KC10.86442077
49RPS6KL10.86442077
50LYN0.85072435
51PDPK10.84813046
52PIM10.83248186
53GRK70.83113021
54NEK20.81724163
55EIF2AK10.79877478
56MAP2K60.77990464
57IRAK10.73339936
58TNK20.73128453
59JAK30.72831927
60PAK40.69270386
61TRIB30.68540136
62MARK20.67872527
63CSF1R0.67584659
64LCK0.64183896
65RPS6KA50.63133676
66SRPK10.62647679
67PRKCQ0.58932338
68MAPKAPK20.58359495
69MARK30.56155842
70CDC42BPA0.53190318
71KIT0.51904104
72PDK10.50557446
73PRKD10.50303627
74RPS6KA10.49947412
75JAK20.48682180
76ITK0.45537187
77PRKCI0.45227816
78RAF10.45066978
79JAK10.42827385
80HIPK20.41689589
81STK100.40981010
82BUB10.39844524
83MELK0.39158911
84IRAK20.38477677
85ADRBK20.36981974
86SIK30.36891652
87PASK0.36271753
88MAPK110.35905038
89FGR0.35298082
90ABL10.34798213
91CDK40.34747026
92CDK90.34575786
93CDK30.33880763
94MAPK30.31717570
95MAPK120.30899085
96EPHA20.30765353
97MOS0.30663053
98ADRBK10.27932415
99RPS6KA20.27368561
100BCKDK0.24396991

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.77965369
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55859390
3Other glycan degradation_Homo sapiens_hsa005112.41122882
4Graft-versus-host disease_Homo sapiens_hsa053322.33991392
5Leishmaniasis_Homo sapiens_hsa051402.17290672
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.15639310
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08138583
8Allograft rejection_Homo sapiens_hsa053302.06100230
9Oxidative phosphorylation_Homo sapiens_hsa001902.04910833
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.03517182
11Osteoclast differentiation_Homo sapiens_hsa043801.98917905
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.97371951
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95253913
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88208041
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84531453
16Autoimmune thyroid disease_Homo sapiens_hsa053201.78319932
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69392746
18Primary immunodeficiency_Homo sapiens_hsa053401.62456041
19B cell receptor signaling pathway_Homo sapiens_hsa046621.61612345
20Rheumatoid arthritis_Homo sapiens_hsa053231.58246705
21Legionellosis_Homo sapiens_hsa051341.52951256
22Type I diabetes mellitus_Homo sapiens_hsa049401.47882763
23Malaria_Homo sapiens_hsa051441.45840177
24Tuberculosis_Homo sapiens_hsa051521.45356436
25Antigen processing and presentation_Homo sapiens_hsa046121.45261307
26Measles_Homo sapiens_hsa051621.42961403
27RNA polymerase_Homo sapiens_hsa030201.41862141
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41299889
29Influenza A_Homo sapiens_hsa051641.38919934
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38608537
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36889156
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36559749
33Parkinsons disease_Homo sapiens_hsa050121.36185736
34TNF signaling pathway_Homo sapiens_hsa046681.35564598
35Lysosome_Homo sapiens_hsa041421.32632275
36Herpes simplex infection_Homo sapiens_hsa051681.30760793
37Collecting duct acid secretion_Homo sapiens_hsa049661.28555256
38Shigellosis_Homo sapiens_hsa051311.26254599
39Toxoplasmosis_Homo sapiens_hsa051451.25494372
40Hematopoietic cell lineage_Homo sapiens_hsa046401.23381698
41Staphylococcus aureus infection_Homo sapiens_hsa051501.20689094
42Epstein-Barr virus infection_Homo sapiens_hsa051691.20440501
43African trypanosomiasis_Homo sapiens_hsa051431.19608862
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17316822
45Chemokine signaling pathway_Homo sapiens_hsa040621.16778721
46Apoptosis_Homo sapiens_hsa042101.14437970
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09118669
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.09068388
49Salmonella infection_Homo sapiens_hsa051321.07662448
50T cell receptor signaling pathway_Homo sapiens_hsa046601.07212019
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04879716
52Asthma_Homo sapiens_hsa053101.04090944
53Phagosome_Homo sapiens_hsa041451.01641710
54Hepatitis C_Homo sapiens_hsa051601.01137624
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99278690
56Hepatitis B_Homo sapiens_hsa051610.93818112
57Acute myeloid leukemia_Homo sapiens_hsa052210.91922991
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87378374
59Huntingtons disease_Homo sapiens_hsa050160.87007690
60Sulfur relay system_Homo sapiens_hsa041220.86856667
61Alzheimers disease_Homo sapiens_hsa050100.82319388
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82127774
63Regulation of autophagy_Homo sapiens_hsa041400.81427269
64Pertussis_Homo sapiens_hsa051330.80284141
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78471607
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78415029
67Renal cell carcinoma_Homo sapiens_hsa052110.70904960
68Homologous recombination_Homo sapiens_hsa034400.70264301
69Systemic lupus erythematosus_Homo sapiens_hsa053220.69793000
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67884142
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67329368
72Proteasome_Homo sapiens_hsa030500.67256175
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65930803
74Spliceosome_Homo sapiens_hsa030400.63866053
75Viral myocarditis_Homo sapiens_hsa054160.63849238
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61520048
77HIF-1 signaling pathway_Homo sapiens_hsa040660.60759694
78Endocytosis_Homo sapiens_hsa041440.58976660
79Fanconi anemia pathway_Homo sapiens_hsa034600.57387240
80Protein export_Homo sapiens_hsa030600.56209592
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.56186710
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53989308
83Viral carcinogenesis_Homo sapiens_hsa052030.51696736
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.48623571
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46156211
86HTLV-I infection_Homo sapiens_hsa051660.44974137
87Prolactin signaling pathway_Homo sapiens_hsa049170.43880456
88Basal transcription factors_Homo sapiens_hsa030220.41953479
89Nucleotide excision repair_Homo sapiens_hsa034200.41594623
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40912081
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.39251147
92Pyrimidine metabolism_Homo sapiens_hsa002400.38479772
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36552917
94Insulin resistance_Homo sapiens_hsa049310.36106740
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35971601
96Chronic myeloid leukemia_Homo sapiens_hsa052200.35618520
97Mineral absorption_Homo sapiens_hsa049780.34328541
98MAPK signaling pathway_Homo sapiens_hsa040100.33829643
99Vitamin digestion and absorption_Homo sapiens_hsa049770.32091927
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31014759

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