TMEM265

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)5.93998992
2keratinocyte development (GO:0003334)5.44047338
3calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.27755436
4establishment of skin barrier (GO:0061436)4.97980985
5DNA deamination (GO:0045006)4.63676021
6ribosomal small subunit assembly (GO:0000028)4.46780739
7positive regulation of interleukin-8 secretion (GO:2000484)4.45433620
8regulation of water loss via skin (GO:0033561)4.42654884
9negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.15711892
10vitamin transmembrane transport (GO:0035461)4.07991876
11bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06113759
12cellular response to zinc ion (GO:0071294)4.04528540
13regulation of cell proliferation involved in kidney development (GO:1901722)4.04165103
14ribosomal small subunit biogenesis (GO:0042274)3.88820695
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76552657
16response to peptidoglycan (GO:0032494)3.74941021
17maturation of SSU-rRNA (GO:0030490)3.74716370
18viral mRNA export from host cell nucleus (GO:0046784)3.53652819
19nucleoside transmembrane transport (GO:1901642)3.49779031
20response to interferon-beta (GO:0035456)3.43293828
21oligosaccharide catabolic process (GO:0009313)3.42253429
22sphingoid metabolic process (GO:0046519)3.35173515
23protein deneddylation (GO:0000338)3.34406640
24desmosome organization (GO:0002934)3.31182312
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30217299
26regulation of autophagic vacuole assembly (GO:2000785)3.26816926
27telomere maintenance via semi-conservative replication (GO:0032201)3.23942856
28viral transcription (GO:0019083)3.23546484
29negative regulation of execution phase of apoptosis (GO:1900118)3.23283847
30hemidesmosome assembly (GO:0031581)3.22562883
31regulation of vacuole organization (GO:0044088)3.19711360
32regulation of chemokine secretion (GO:0090196)3.18937518
33ribosomal large subunit biogenesis (GO:0042273)3.18001211
34nucleoside salvage (GO:0043174)3.16928669
35DNA strand elongation involved in DNA replication (GO:0006271)3.16356254
36pseudouridine synthesis (GO:0001522)3.15779609
37positive regulation of chemokine secretion (GO:0090197)3.13747571
38NIK/NF-kappaB signaling (GO:0038061)3.13154367
39translational termination (GO:0006415)3.10729106
40DNA strand elongation (GO:0022616)3.10721015
41telomere maintenance via recombination (GO:0000722)3.07459673
42cullin deneddylation (GO:0010388)3.04005854
43keratinization (GO:0031424)3.03476449
44termination of RNA polymerase III transcription (GO:0006386)3.01859433
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.01859433
46pyrimidine nucleoside salvage (GO:0043097)3.01688505
47pyrimidine-containing compound salvage (GO:0008655)3.01688505
48nucleoside transport (GO:0015858)3.00544886
49GDP-mannose metabolic process (GO:0019673)2.99002502
50positive regulation of antigen processing and presentation (GO:0002579)2.97266295
51regulation of interleukin-8 secretion (GO:2000482)2.94122261
52negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.93878824
53DNA catabolic process, exonucleolytic (GO:0000738)2.93836359
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92967400
55ncRNA 3-end processing (GO:0043628)2.92118350
56positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89152045
57kinetochore assembly (GO:0051382)2.89100155
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88532393
59kinetochore organization (GO:0051383)2.86789219
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85132525
61DNA replication initiation (GO:0006270)2.83491537
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82169281
63glutathione biosynthetic process (GO:0006750)2.82127218
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81092701
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81092701
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81092701
67type B pancreatic cell proliferation (GO:0044342)2.81090361
68ribonucleoprotein complex biogenesis (GO:0022613)2.79128026
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78870686
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78870686
71glutathione derivative biosynthetic process (GO:1901687)2.78822757
72glutathione derivative metabolic process (GO:1901685)2.78822757
73CENP-A containing nucleosome assembly (GO:0034080)2.76719370
74negative regulation of viral entry into host cell (GO:0046597)2.76152417
75regulation of transforming growth factor beta1 production (GO:0032908)2.75777343
76cotranslational protein targeting to membrane (GO:0006613)2.75682800
77positive regulation of Cdc42 GTPase activity (GO:0043089)2.74063909
78interferon-gamma production (GO:0032609)2.73996509
79cyclooxygenase pathway (GO:0019371)2.73944649
80translational elongation (GO:0006414)2.72892430
81neutrophil activation involved in immune response (GO:0002283)2.72624081
82regulation of oxidative phosphorylation (GO:0002082)2.72449897
83sequestering of actin monomers (GO:0042989)2.71872479
84protein targeting to ER (GO:0045047)2.71593004
85mitotic recombination (GO:0006312)2.71589194
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71538695
87leukocyte aggregation (GO:0070486)2.71148648
88water homeostasis (GO:0030104)2.70453374
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.69630823
90positive regulation of epidermal cell differentiation (GO:0045606)2.66732660
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66673089
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.66673089
93formation of translation preinitiation complex (GO:0001731)2.66128529
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65800145
95DNA replication checkpoint (GO:0000076)2.65647788
96response to type I interferon (GO:0034340)2.64983663
97regulation of viral entry into host cell (GO:0046596)2.64886449
98organelle membrane fusion (GO:0090174)2.63686653
99type I interferon signaling pathway (GO:0060337)2.63152612
100cellular response to type I interferon (GO:0071357)2.63152612
101hepatocyte apoptotic process (GO:0097284)2.62850187
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62710646
103multicellular organism reproduction (GO:0032504)2.62526387
104virion assembly (GO:0019068)2.62252826
105protein localization to endoplasmic reticulum (GO:0070972)2.62069451
106face development (GO:0060324)2.61528717
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60429857
108multicellular organismal water homeostasis (GO:0050891)2.58997373
109positive regulation of epidermis development (GO:0045684)2.58284439
110meiotic chromosome segregation (GO:0045132)2.58053022
111regulation of ruffle assembly (GO:1900027)2.57838451
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57791659
113regulation of respiratory burst (GO:0060263)2.57125570
114translational initiation (GO:0006413)2.57019043
115nonribosomal peptide biosynthetic process (GO:0019184)2.56331973
116detection of bacterium (GO:0016045)2.55994195
117negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.55695135
118interferon-gamma secretion (GO:0072643)2.55489138
119attachment of spindle microtubules to kinetochore (GO:0008608)2.55404659
120viral life cycle (GO:0019058)2.55129552
121DNA ligation (GO:0006266)2.54868169
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.54716328
123regulation of hypersensitivity (GO:0002883)2.54481190
124DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.54090074
125positive regulation of keratinocyte differentiation (GO:0045618)2.53268932
126chromatin remodeling at centromere (GO:0031055)2.53166747
127autophagic vacuole fusion (GO:0000046)2.52977514
128galactose metabolic process (GO:0006012)2.52931960
129establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51997958
130superoxide anion generation (GO:0042554)2.51744437
131G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.51225656
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51050628
133antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.49961934
134negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.48971849
135poly(A)+ mRNA export from nucleus (GO:0016973)2.48929596
136keratinocyte proliferation (GO:0043616)2.48655286
137telomere maintenance via telomere lengthening (GO:0010833)2.48362984
138regulation of antigen processing and presentation (GO:0002577)2.48319472
139tight junction assembly (GO:0070830)2.48066907
140folic acid transport (GO:0015884)2.47436778
141positive regulation of actin cytoskeleton reorganization (GO:2000251)2.47218021
142opioid receptor signaling pathway (GO:0038003)2.46903876
143negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.46436744
144positive regulation of interleukin-4 production (GO:0032753)2.46361132
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.45567122
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45535443
147regulation of viral release from host cell (GO:1902186)2.45419419
148rRNA processing (GO:0006364)2.44716189
149cellular component biogenesis (GO:0044085)2.44710827
150pinocytosis (GO:0006907)2.44653795
151regulation of apoptotic process involved in morphogenesis (GO:1902337)2.44592845
152positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44233699
153histone H2A acetylation (GO:0043968)2.43687653
154negative regulation of transcription by competitive promoter binding (GO:0010944)2.43606467
155anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43376344
156regulation of cellular amino acid metabolic process (GO:0006521)2.43245717
157mitotic metaphase plate congression (GO:0007080)2.43013190
158proteasome assembly (GO:0043248)2.42811581
159maturation of 5.8S rRNA (GO:0000460)2.42534812
160determination of adult lifespan (GO:0008340)2.42493895
161L-fucose catabolic process (GO:0042355)2.42280753
162fucose catabolic process (GO:0019317)2.42280753
163L-fucose metabolic process (GO:0042354)2.42280753
164antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41439296
165positive regulation of protein homooligomerization (GO:0032464)2.41117857
166negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39272549
167diterpenoid biosynthetic process (GO:0016102)2.38679925
168antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35048860
169viral protein processing (GO:0019082)2.34545749
170carbohydrate derivative transport (GO:1901264)2.33583952
171cornea development in camera-type eye (GO:0061303)2.33453547
172chronic inflammatory response (GO:0002544)2.33289084
173endosome organization (GO:0007032)2.30103780
174amyloid precursor protein metabolic process (GO:0042982)2.29758572
175purinergic nucleotide receptor signaling pathway (GO:0035590)2.28574719
176ectoderm development (GO:0007398)2.25839556
177lipoxygenase pathway (GO:0019372)2.23078158
178cytokine biosynthetic process (GO:0042089)2.23023830
179regulation of cellular extravasation (GO:0002691)2.22461317
180positive regulation of respiratory burst (GO:0060267)2.20421747
181galactose catabolic process (GO:0019388)2.20126493
182base-excision repair, AP site formation (GO:0006285)2.19947741
183chemosensory behavior (GO:0007635)2.19628400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72148528
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.55837773
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41094812
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38379123
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33223759
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.00655502
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98465974
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.93109088
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.87208083
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84869764
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64126294
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60998749
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.49858355
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.49642064
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48160404
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41379356
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41295163
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.37334449
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34025824
20VDR_23849224_ChIP-Seq_CD4+_Human2.32716832
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30675390
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.27822148
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25727589
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24008375
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19421195
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19259165
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17928805
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11693360
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04337338
30FOXP3_21729870_ChIP-Seq_TREG_Human2.04182604
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02365413
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01399854
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96717895
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95586519
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94311971
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93469129
37BCOR_27268052_Chip-Seq_Bcells_Human1.92413590
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.90109470
39RACK7_27058665_Chip-Seq_MCF-7_Human1.88840322
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88535517
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.87542850
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82503412
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82379061
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82254866
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81037701
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79273392
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78976412
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78966631
49ELK1_19687146_ChIP-ChIP_HELA_Human1.78296938
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.77305912
51TTF2_22483619_ChIP-Seq_HELA_Human1.74793033
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71493686
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.70949526
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69031894
55XRN2_22483619_ChIP-Seq_HELA_Human1.68179248
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67135131
57BCL6_27268052_Chip-Seq_Bcells_Human1.66088372
58DCP1A_22483619_ChIP-Seq_HELA_Human1.65186881
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.62132147
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60530628
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.58885460
62ATF3_27146783_Chip-Seq_COLON_Human1.58613777
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57543009
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57543009
65P68_20966046_ChIP-Seq_HELA_Human1.51430915
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50290259
67ELF5_23300383_ChIP-Seq_T47D_Human1.49110085
68CIITA_25753668_ChIP-Seq_RAJI_Human1.49097041
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48597568
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48403110
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.48365267
72GABP_19822575_ChIP-Seq_HepG2_Human1.46602563
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45282440
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.43460775
75LXR_22292898_ChIP-Seq_THP-1_Human1.43167769
76SPI1_23547873_ChIP-Seq_NB4_Human1.42771999
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41097684
78VDR_21846776_ChIP-Seq_THP-1_Human1.40826226
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40728385
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40354873
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39769793
82SMC4_20622854_ChIP-Seq_HELA_Human1.39202369
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39083213
84ZNF263_19887448_ChIP-Seq_K562_Human1.38733337
85P300_27268052_Chip-Seq_Bcells_Human1.37210958
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37037907
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.36750749
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.36719292
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35515181
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34512741
91TP63_22573176_ChIP-Seq_HFKS_Human1.34194911
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.33530342
93E2F1_20622854_ChIP-Seq_HELA_Human1.33383504
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33246566
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32545106
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32318705
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30987509
98MYC_18940864_ChIP-ChIP_HL60_Human1.30969298
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30156770
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29848601
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28618274
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28167868
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26536664
104GATA6_25053715_ChIP-Seq_YYC3_Human1.26093573
105CTCF_20526341_ChIP-Seq_ESCs_Human1.25512873
106SOX2_20726797_ChIP-Seq_SW620_Human1.25217269
107AR_21909140_ChIP-Seq_LNCAP_Human1.24930915
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24874235
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24815898
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.24370214
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23905285
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.22902616
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.22571381
114IRF8_22096565_ChIP-ChIP_GC-B_Human1.22542282
115PHF8_20622854_ChIP-Seq_HELA_Human1.21930464
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21423254
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20848172
118GATA3_24758297_ChIP-Seq_MCF-7_Human1.18340604
119STAT1_20625510_ChIP-Seq_HELA_Human1.17658644
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17645277
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17210147
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16621094
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16301228
124THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15320511
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14489090
126P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11565011
127MYC_22102868_ChIP-Seq_BL_Human1.10914338
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10674517
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08725705
130IRF1_19129219_ChIP-ChIP_H3396_Human1.08463941
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08109079
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07716526
133NANOG_20526341_ChIP-Seq_ESCs_Human1.07360080
134SA1_27219007_Chip-Seq_Bcells_Human1.06031710
135STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05647794
136MYB_26560356_Chip-Seq_TH2_Human1.05621193
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04765620
138VDR_24763502_ChIP-Seq_THP-1_Human1.03477703
139GATA2_21666600_ChIP-Seq_HMVEC_Human1.03104651
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02536270
141MAF_26560356_Chip-Seq_TH2_Human1.02040213
142RXR_22158963_ChIP-Seq_LIVER_Mouse1.01495102
143EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00781100
144GATA4_25053715_ChIP-Seq_YYC3_Human0.99825895
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99458149
146ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99153236
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98811045
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98455101
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98333031
150CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97629136
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97529696
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96643163
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96337339
154FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92804910
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92588967
156PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92321314
157P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91551328
158MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88943116
159MYB_26560356_Chip-Seq_TH1_Human0.88348666
160SALL1_21062744_ChIP-ChIP_HESCs_Human0.86070906
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85656592
162MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85558111
163SCL_19346495_ChIP-Seq_HPC-7_Human0.83157676
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82793572
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82736558
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82610302
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.82150962
168EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81569022
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80413042
170GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80405509
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78717467
172KDM5A_27292631_Chip-Seq_BREAST_Human0.78662931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.25679060
2MP0003806_abnormal_nucleotide_metabolis4.61799980
3MP0003941_abnormal_skin_development4.06635587
4MP0002796_impaired_skin_barrier3.70697247
5MP0003763_abnormal_thymus_physiology3.49804849
6MP0004264_abnormal_extraembryonic_tissu3.38424602
7MP0005451_abnormal_body_composition3.30736030
8MP0010094_abnormal_chromosome_stability2.86922646
9MP0004381_abnormal_hair_follicle2.84952595
10MP0008057_abnormal_DNA_replication2.70529133
11MP0001835_abnormal_antigen_presentation2.69971917
12MP0002138_abnormal_hepatobiliary_system2.69240439
13MP0004957_abnormal_blastocyst_morpholog2.51521655
14MP0005501_abnormal_skin_physiology2.42586200
15MP0003693_abnormal_embryo_hatching2.42500163
16MP0003111_abnormal_nucleus_morphology2.35796898
17MP0003191_abnormal_cellular_cholesterol2.32246656
18MP0008058_abnormal_DNA_repair2.20307689
19MP0010678_abnormal_skin_adnexa2.19362752
20MP0005671_abnormal_response_to2.16668341
21MP0000566_synostosis2.11160078
22MP0005075_abnormal_melanosome_morpholog2.05186711
23MP0008007_abnormal_cellular_replicative2.04375088
24MP0003077_abnormal_cell_cycle2.00919830
25MP0005083_abnormal_biliary_tract1.96458404
26MP0001216_abnormal_epidermal_layer1.95705415
27MP0004782_abnormal_surfactant_physiolog1.93550975
28MP0000685_abnormal_immune_system1.92582147
29MP0002148_abnormal_hypersensitivity_rea1.86445538
30MP0002254_reproductive_system_inflammat1.83256324
31MP0000678_abnormal_parathyroid_gland1.81985888
32MP0000579_abnormal_nail_morphology1.77431719
33MP0002060_abnormal_skin_morphology1.70185491
34MP0005058_abnormal_lysosome_morphology1.69248735
35MP0008875_abnormal_xenobiotic_pharmacok1.67675548
36MP0001800_abnormal_humoral_immune1.66465906
37MP0002398_abnormal_bone_marrow1.64115761
38MP0002098_abnormal_vibrissa_morphology1.63089610
39MP0002009_preneoplasia1.60832129
40MP0003453_abnormal_keratinocyte_physiol1.59503997
41MP0002396_abnormal_hematopoietic_system1.57349661
42MP0004947_skin_inflammation1.54944537
43MP0003786_premature_aging1.54759241
44MP0002277_abnormal_respiratory_mucosa1.51445055
45MP0010352_gastrointestinal_tract_polyps1.50824082
46MP0002420_abnormal_adaptive_immunity1.50027621
47MP0003566_abnormal_cell_adhesion1.49249551
48MP0006292_abnormal_olfactory_placode1.48164641
49MP0009785_altered_susceptibility_to1.47443530
50MP0000762_abnormal_tongue_morphology1.47326278
51MP0001819_abnormal_immune_cell1.47094205
52MP0005000_abnormal_immune_tolerance1.44881452
53MP0005248_abnormal_Harderian_gland1.44522209
54MP0006036_abnormal_mitochondrial_physio1.42740791
55MP0000015_abnormal_ear_pigmentation1.41563955
56MP0003878_abnormal_ear_physiology1.41547475
57MP0005377_hearing/vestibular/ear_phenot1.41547475
58MP0009333_abnormal_splenocyte_physiolog1.39794393
59MP0000490_abnormal_crypts_of1.37953014
60MP0002452_abnormal_antigen_presenting1.36100189
61MP0002405_respiratory_system_inflammati1.35970022
62MP0000858_altered_metastatic_potential1.35500576
63MP0008789_abnormal_olfactory_epithelium1.35256434
64MP0009840_abnormal_foam_cell1.35162588
65MP0001853_heart_inflammation1.33939456
66MP0002723_abnormal_immune_serum1.33931700
67MP0003890_abnormal_embryonic-extraembry1.32917947
68MP0000703_abnormal_thymus_morphology1.32496190
69MP0002722_abnormal_immune_system1.32378009
70MP0005025_abnormal_response_to1.31750043
71MP0010771_integument_phenotype1.30950429
72MP0000716_abnormal_immune_system1.27629970
73MP0005387_immune_system_phenotype1.25851653
74MP0001790_abnormal_immune_system1.25851653
75MP0002163_abnormal_gland_morphology1.23079595
76MP0002132_abnormal_respiratory_system1.22719485
77MP0000689_abnormal_spleen_morphology1.21505539
78MP0003315_abnormal_perineum_morphology1.20643600
79MP0000537_abnormal_urethra_morphology1.20383439
80MP0003718_maternal_effect1.20013401
81MP0005023_abnormal_wound_healing1.18803455
82MP0004019_abnormal_vitamin_homeostasis1.18396674
83MP0003436_decreased_susceptibility_to1.16966191
84MP0009764_decreased_sensitivity_to1.16855328
85MP0002019_abnormal_tumor_incidence1.16173718
86MP0004510_myositis1.13958704
87MP0002429_abnormal_blood_cell1.12291405
88MP0009643_abnormal_urine_homeostasis1.11774908
89MP0005360_urolithiasis1.11692474
90MP0001346_abnormal_lacrimal_gland1.10654088
91MP0009379_abnormal_foot_pigmentation1.10444401
92MP0009780_abnormal_chondrocyte_physiolo1.08602264
93MP0009697_abnormal_copulation1.08343628
94MP0008932_abnormal_embryonic_tissue1.06751153
95MP0001243_abnormal_dermal_layer1.04659233
96MP0002876_abnormal_thyroid_physiology1.04035521
97MP0003787_abnormal_imprinting1.04023550
98MP0010155_abnormal_intestine_physiology1.03897759
99MP0009931_abnormal_skin_appearance1.03273955
100MP0001849_ear_inflammation1.02647266
101MP0001851_eye_inflammation1.02496043
102MP0000465_gastrointestinal_hemorrhage1.01464891
103MP0003950_abnormal_plasma_membrane0.98833344
104MP0000377_abnormal_hair_follicle0.98642104
105MP0000383_abnormal_hair_follicle0.98367939
106MP0003943_abnormal_hepatobiliary_system0.98069154
107MP0001119_abnormal_female_reproductive0.96426905
108MP0005410_abnormal_fertilization0.94694054
109MP0000427_abnormal_hair_cycle0.92509087
110MP0001191_abnormal_skin_condition0.92368824
111MP0002006_tumorigenesis0.92296760
112MP0003195_calcinosis0.89417256
113MP0002095_abnormal_skin_pigmentation0.88995594
114MP0001873_stomach_inflammation0.88421656
115MP0000367_abnormal_coat/_hair0.88175358
116MP0002166_altered_tumor_susceptibility0.87813559
117MP0004808_abnormal_hematopoietic_stem0.87797266
118MP0005174_abnormal_tail_pigmentation0.87618711
119MP0002419_abnormal_innate_immunity0.87402372
120MP0008469_abnormal_protein_level0.87230047
121MP0001986_abnormal_taste_sensitivity0.85168663
122MP0000350_abnormal_cell_proliferation0.84732608
123MP0003866_abnormal_defecation0.84262922
124MP0005408_hypopigmentation0.84241529
125MP0006035_abnormal_mitochondrial_morpho0.83990022
126MP0005464_abnormal_platelet_physiology0.83642337
127MP0001845_abnormal_inflammatory_respons0.83452114
128MP0008004_abnormal_stomach_pH0.82970148
129MP0008877_abnormal_DNA_methylation0.81995465
130MP0009765_abnormal_xenobiotic_induced0.81486318
131MP0005166_decreased_susceptibility_to0.79018927
132MP0003186_abnormal_redox_activity0.78916906
133MP0005275_abnormal_skin_tensile0.78686030
134MP0008260_abnormal_autophagy0.78672233
135MP0001919_abnormal_reproductive_system0.78630239
136MP0005367_renal/urinary_system_phenotyp0.77921955
137MP0000516_abnormal_urinary_system0.77921955
138MP0005499_abnormal_olfactory_system0.77701401
139MP0005394_taste/olfaction_phenotype0.77701401
140MP0000470_abnormal_stomach_morphology0.77427992
141MP0000647_abnormal_sebaceous_gland0.76631789
142MP0003724_increased_susceptibility_to0.76187034
143MP0002210_abnormal_sex_determination0.75777955
144MP0000467_abnormal_esophagus_morphology0.75552396
145MP0003638_abnormal_response/metabolism_0.73437121
146MP0001533_abnormal_skeleton_physiology0.72034706
147MP0001765_abnormal_ion_homeostasis0.71071636
148MP0005636_abnormal_mineral_homeostasis0.70222058
149MP0005365_abnormal_bile_salt0.70067019

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.37288094
2Alopecia of scalp (HP:0002293)4.31767425
3Lip pit (HP:0100267)4.23834409
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.17356628
5Right ventricular cardiomyopathy (HP:0011663)3.96558482
6Plantar hyperkeratosis (HP:0007556)3.92835929
7Palmoplantar hyperkeratosis (HP:0000972)3.64278840
8Congenital ichthyosiform erythroderma (HP:0007431)3.63427709
9Palmar hyperkeratosis (HP:0010765)3.55688405
10Eczematoid dermatitis (HP:0000976)3.39590562
11Reticulocytopenia (HP:0001896)3.39151970
12Pili torti (HP:0003777)3.22521340
13Erythema (HP:0010783)3.11668102
14Onycholysis (HP:0001806)3.07180835
15Elevated erythrocyte sedimentation rate (HP:0003565)3.07130348
16Thick nail (HP:0001805)3.01539511
17Birth length less than 3rd percentile (HP:0003561)3.01335131
1811 pairs of ribs (HP:0000878)2.96563050
19Abnormality of cells of the erythroid lineage (HP:0012130)2.92949256
20IgM deficiency (HP:0002850)2.86368836
21Abnormal number of erythroid precursors (HP:0012131)2.84177536
22Increased IgE level (HP:0003212)2.78848766
23Nail dystrophy (HP:0008404)2.78122745
24Myositis (HP:0100614)2.77293987
25Hypokinesia (HP:0002375)2.72615971
26Degeneration of anterior horn cells (HP:0002398)2.71162984
27Abnormality of the anterior horn cell (HP:0006802)2.71162984
28Parakeratosis (HP:0001036)2.70974380
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68985076
30Double outlet right ventricle (HP:0001719)2.68441103
31Congenital malformation of the right heart (HP:0011723)2.68441103
32Milia (HP:0001056)2.60695604
33Gangrene (HP:0100758)2.60058715
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59193587
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59193587
36Abnormality of macrophages (HP:0004311)2.59040265
37Patellar aplasia (HP:0006443)2.55633110
38Abnormality of the preputium (HP:0100587)2.54444694
39Sparse eyelashes (HP:0000653)2.51492656
40Abnormal hair laboratory examination (HP:0003328)2.49186039
41Type 2 muscle fiber atrophy (HP:0003554)2.48196039
42Chromsome breakage (HP:0040012)2.43593767
43Villous atrophy (HP:0011473)2.42112594
44Abnormality of small intestinal villus morphology (HP:0011472)2.42112594
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.40569950
46Abnormality of magnesium homeostasis (HP:0004921)2.35894545
47IgG deficiency (HP:0004315)2.35720817
48Fragile nails (HP:0001808)2.35569341
49Sparse scalp hair (HP:0002209)2.35114023
50Breast hypoplasia (HP:0003187)2.34313465
51Panhypogammaglobulinemia (HP:0003139)2.33345185
52Aplasia/Hypoplasia of the patella (HP:0006498)2.32295353
53Muscle fiber atrophy (HP:0100295)2.31992415
54Hypomagnesemia (HP:0002917)2.31481202
55Abnormal blistering of the skin (HP:0008066)2.30243361
56Keratoconjunctivitis (HP:0001096)2.28089039
57Increased IgM level (HP:0003496)2.27147569
58Hypotrichosis (HP:0001006)2.26990977
59Agammaglobulinemia (HP:0004432)2.26858585
60Ketosis (HP:0001946)2.23901686
61Cheilitis (HP:0100825)2.23514831
62Xerostomia (HP:0000217)2.22829240
63Tetany (HP:0001281)2.22288089
64Optic neuritis (HP:0100653)2.21401108
65Retrobulbar optic neuritis (HP:0100654)2.21401108
66Respiratory difficulties (HP:0002880)2.21161505
67Popliteal pterygium (HP:0009756)2.20814310
68Hypoplasia of the uterus (HP:0000013)2.19990977
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19625241
70Abnormal protein N-linked glycosylation (HP:0012347)2.19625241
71Abnormal protein glycosylation (HP:0012346)2.19625241
72Abnormal glycosylation (HP:0012345)2.19625241
73Ureteral duplication (HP:0000073)2.18589738
74Increased cerebral lipofuscin (HP:0011813)2.18093185
75Chronic mucocutaneous candidiasis (HP:0002728)2.16508547
76Recurrent cutaneous fungal infections (HP:0011370)2.16508547
77Encephalitis (HP:0002383)2.14585319
78Petechiae (HP:0000967)2.12793056
79Recurrent abscess formation (HP:0002722)2.12667570
80Aplasia/hypoplasia of the uterus (HP:0008684)2.11986184
81Recurrent fungal infections (HP:0002841)2.10610313
82Reduced antithrombin III activity (HP:0001976)2.07946777
83Corneal erosion (HP:0200020)2.07487810
84Hepatocellular necrosis (HP:0001404)2.05486830
85Anhidrosis (HP:0000970)2.05127623
86Vascular calcification (HP:0004934)2.04596085
87Erythroderma (HP:0001019)2.03787545
88Abnormality of liposaccharide metabolism (HP:0010968)2.02697311
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.02697311
90Abnormality of glycolipid metabolism (HP:0010969)2.02697311
91Ectropion (HP:0000656)2.01846821
92Abnormality of midbrain morphology (HP:0002418)2.01247075
93Molar tooth sign on MRI (HP:0002419)2.01247075
94Chronic sinusitis (HP:0011109)2.01157271
95Ketoacidosis (HP:0001993)1.99871314
96Abnormality of dental color (HP:0011073)1.99743443
97Inflammation of the large intestine (HP:0002037)1.98750952
98Axonal loss (HP:0003447)1.98641275
99Pruritus (HP:0000989)1.98258538
100Recurrent bacterial skin infections (HP:0005406)1.96715716
101Colitis (HP:0002583)1.96155343
102Hypergammaglobulinemia (HP:0010702)1.95786841
103Hepatic necrosis (HP:0002605)1.95486573
104Mitochondrial inheritance (HP:0001427)1.95363256
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95130476
106Gastrointestinal inflammation (HP:0004386)1.94837149
107Severe combined immunodeficiency (HP:0004430)1.94190786
108Pustule (HP:0200039)1.92860979
109Furrowed tongue (HP:0000221)1.92110342
110Keratoconjunctivitis sicca (HP:0001097)1.92034686
111Meningitis (HP:0001287)1.91888280
112Hypohidrosis (HP:0000966)1.91637725
113Reduced subcutaneous adipose tissue (HP:0003758)1.91541518
114Orchitis (HP:0100796)1.91023530
115Granulocytopenia (HP:0001913)1.90488369
116Hypothermia (HP:0002045)1.89580603
1173-Methylglutaconic aciduria (HP:0003535)1.88720627
118Combined immunodeficiency (HP:0005387)1.88680157
119Abnormal lung lobation (HP:0002101)1.88624225
120Pulmonary fibrosis (HP:0002206)1.88296391
121Duplicated collecting system (HP:0000081)1.87802641
122Aplastic anemia (HP:0001915)1.87484837
123Dry hair (HP:0011359)1.87282900
124Abnormality of nail color (HP:0100643)1.87008709
125Myelodysplasia (HP:0002863)1.86347034
126Clubbing of toes (HP:0100760)1.85887625
127Pulmonary infiltrates (HP:0002113)1.84957546
128Type I transferrin isoform profile (HP:0003642)1.83929120
129Recurrent skin infections (HP:0001581)1.83573569
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83524401
131Bile duct proliferation (HP:0001408)1.82762096
132Abnormal biliary tract physiology (HP:0012439)1.82762096
133Lymphoma (HP:0002665)1.82664588
134True hermaphroditism (HP:0010459)1.82083284
135Oral leukoplakia (HP:0002745)1.81846376
136Abnormal hair whorl (HP:0010721)1.81823469
137Trismus (HP:0000211)1.81481752
138Dry skin (HP:0000958)1.81336006
139Hyperinsulinemic hypoglycemia (HP:0000825)1.81038383
140Woolly hair (HP:0002224)1.80956139
141Colon cancer (HP:0003003)1.80373824
142Septo-optic dysplasia (HP:0100842)1.80061917
143Amelogenesis imperfecta (HP:0000705)1.79946678
144Urticaria (HP:0001025)1.79789484
145Abnormality of the ileum (HP:0001549)1.79147404
146Bone marrow hypocellularity (HP:0005528)1.78822009
147Skin rash (HP:0000988)1.78173790
148Obstructive lung disease (HP:0006536)1.78161607
149Chronic obstructive pulmonary disease (HP:0006510)1.78161607
150Hypoplastic labia majora (HP:0000059)1.77330209
151Prolonged neonatal jaundice (HP:0006579)1.76865922
152Ridged nail (HP:0001807)1.76078747
153Hyporeflexia of lower limbs (HP:0002600)1.76028921
154Abnormality of the axillary hair (HP:0100134)1.75856599
155Abnormality of secondary sexual hair (HP:0009888)1.75856599
156Intestinal atresia (HP:0011100)1.75266341
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.75179365
158Absent thumb (HP:0009777)1.74826469
159Thrombocytosis (HP:0001894)1.73803245
160Asplenia (HP:0001746)1.73768744
161Cleft eyelid (HP:0000625)1.72850355
162Microcytic anemia (HP:0001935)1.72824651
163Abnormality of pyrimidine metabolism (HP:0004353)1.71913483
164Mediastinal lymphadenopathy (HP:0100721)1.71815045
165Meckel diverticulum (HP:0002245)1.71721559
166Distal lower limb muscle weakness (HP:0009053)1.71663621
167Skin ulcer (HP:0200042)1.71311022
168Abnormality of endocrine pancreas physiology (HP:0012093)1.71123391
169Abnormality of the pancreatic islet cells (HP:0006476)1.71123391
170Microretrognathia (HP:0000308)1.70617938
171Increased CSF lactate (HP:0002490)1.70224155
172Acute necrotizing encephalopathy (HP:0006965)1.69911928
173Abnormal mitochondria in muscle tissue (HP:0008316)1.68451464
174Abnormality of the renal collecting system (HP:0004742)1.66671231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K133.80818273
2MST1R3.06402912
3MET2.82967818
4NLK2.77343975
5STK242.67183642
6TXK2.58658461
7VRK22.44298622
8MST42.44045127
9MAP3K142.40039388
10PIM22.36080373
11BUB12.17152211
12BMPR22.16781030
13PLK42.06815911
14TESK22.04126862
15TNIK1.99815268
16PINK11.95099375
17INSRR1.93439518
18ERBB31.87972263
19SIK31.87062417
20SRPK11.81721714
21STK161.78190178
22GRK11.78079435
23CDC71.77978110
24MAP4K11.77730162
25MKNK11.75683441
26EIF2AK11.75550112
27ABL21.73774383
28MAPKAPK31.72171795
29IRAK41.69817419
30TRIM281.69135959
31BTK1.67017387
32ZAP701.65782717
33IKBKE1.64074543
34RPS6KB21.55710521
35NME21.53534480
36PBK1.52901908
37MAP3K11.52626112
38MARK31.52379035
39LMTK21.52040307
40FRK1.51462303
41ARAF1.49312638
42VRK11.46428457
43TGFBR11.44192026
44STK38L1.41665077
45TRPM71.41069858
46TEC1.40943822
47PASK1.38524479
48STK101.37383108
49DYRK31.34157275
50KIT1.32702799
51EPHB21.32218608
52TYK21.30948593
53MAP3K21.27808355
54WEE11.23146777
55TTK1.20163513
56YES11.19725743
57RPS6KA41.19615960
58EIF2AK21.18424930
59ADRBK21.18257489
60MAP3K31.17891303
61SYK1.17144259
62TAOK11.16763145
63IKBKB1.16500999
64PKN21.15887740
65TSSK61.15807356
66IRAK31.15027753
67AKT31.14527770
68EIF2AK31.10873087
69EPHB11.10749910
70PLK31.10747004
71ERN11.10013577
72CCNB11.08600870
73PIM11.08472892
74CDK31.07705731
75MUSK1.05661106
76PRKCI1.04192691
77JAK31.03733285
78MAP3K121.02079234
79PLK11.01866892
80NME10.98841367
81CLK10.97867079
82DYRK20.97517307
83SMG10.97049000
84CHUK0.96660373
85ITK0.94099437
86LRRK20.91546493
87FER0.91409514
88ZAK0.88079568
89BRSK20.86922119
90AURKB0.86615334
91BMPR1B0.86419966
92CDK80.86379214
93SGK20.85372670
94TBK10.84303666
95BRAF0.84285986
96GRK60.84094612
97MAP3K110.83003956
98IRAK10.79974664
99LIMK10.79547267
100IRAK20.79513168
101AURKA0.78914021
102SIK10.77925201
103PAK40.75988008
104MKNK20.75653262
105ATR0.72365269
106EEF2K0.71896003
107NEK20.71538496
108LYN0.70351012
109BLK0.69535085
110LATS10.69166654
111CHEK20.68679779
112CSNK1G30.68634753
113MAPKAPK20.67765857
114PDK20.67709040
115BCKDK0.67625426
116ILK0.67287490
117CSF1R0.64143385
118RPS6KL10.63632971
119RPS6KC10.63632971
120BCR0.62436505
121CDK70.62117678
122MAP3K70.61073972
123TESK10.60775584
124RPS6KA60.60554794
125PTK60.59650696
126EPHA20.59350249
127RPS6KB10.59335939
128STK380.58567119
129PRKG20.57122960
130LCK0.56944613
131FLT30.56897557
132STK40.56864977
133MAP2K60.55783100
134HCK0.53672421
135TLK10.53450701
136MAP3K80.53212647
137CSNK2A10.52457711
138CSNK1A1L0.51817136
139CDK40.48858871
140TNK20.47754849
141FGFR30.46579720
142KSR10.45532076
143FGFR20.45332029
144TAOK20.45218199
145CDK90.44938624
146MELK0.44222460
147MAP2K30.43859019
148BRSK10.43842145
149DAPK10.43485719
150PTK20.43154718
151CASK0.42587362
152MAP3K90.42555460
153FGR0.42123700
154MAPK40.41319381
155CSNK1G10.40997428
156ADRBK10.39670339
157EPHA30.39461962
158GRK50.38163798
159MAP2K10.37341643
160CSNK2A20.36991469
161PTK2B0.34646023
162PRKD20.32364725
163TRIB30.29981807
164PRKCQ0.28567488
165MYLK0.28413480

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.64577941
2DNA replication_Homo sapiens_hsa030303.61687566
3Proteasome_Homo sapiens_hsa030503.50350122
4RNA polymerase_Homo sapiens_hsa030203.32743002
5Base excision repair_Homo sapiens_hsa034103.11829368
6Mismatch repair_Homo sapiens_hsa034302.91018094
7Primary immunodeficiency_Homo sapiens_hsa053402.87915590
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61087554
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52066395
10Homologous recombination_Homo sapiens_hsa034402.33355457
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32842291
12Pyrimidine metabolism_Homo sapiens_hsa002402.29386807
13Spliceosome_Homo sapiens_hsa030402.19962750
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.98743421
15Basal transcription factors_Homo sapiens_hsa030221.96985324
16RNA transport_Homo sapiens_hsa030131.95903727
17RNA degradation_Homo sapiens_hsa030181.95552250
18Sulfur relay system_Homo sapiens_hsa041221.87624367
19Collecting duct acid secretion_Homo sapiens_hsa049661.86677118
20Cell cycle_Homo sapiens_hsa041101.83060470
21Galactose metabolism_Homo sapiens_hsa000521.82684479
22Non-homologous end-joining_Homo sapiens_hsa034501.82230952
23Nucleotide excision repair_Homo sapiens_hsa034201.80129034
24Fanconi anemia pathway_Homo sapiens_hsa034601.77767593
25p53 signaling pathway_Homo sapiens_hsa041151.73759109
26Phenylalanine metabolism_Homo sapiens_hsa003601.67740455
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.65003778
28Chemical carcinogenesis_Homo sapiens_hsa052041.57958690
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57556150
30Lysosome_Homo sapiens_hsa041421.55491368
31One carbon pool by folate_Homo sapiens_hsa006701.52007395
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47087109
33Sulfur metabolism_Homo sapiens_hsa009201.42099878
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41299198
35Arachidonic acid metabolism_Homo sapiens_hsa005901.40547375
36Protein export_Homo sapiens_hsa030601.38206533
37Antigen processing and presentation_Homo sapiens_hsa046121.31708789
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.29132873
39Measles_Homo sapiens_hsa051621.25466311
40Herpes simplex infection_Homo sapiens_hsa051681.24742880
41Sphingolipid metabolism_Homo sapiens_hsa006001.23520530
42Folate biosynthesis_Homo sapiens_hsa007901.22473953
43Fructose and mannose metabolism_Homo sapiens_hsa000511.21572152
44Legionellosis_Homo sapiens_hsa051341.20019165
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.18616753
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17701838
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14557370
48Epstein-Barr virus infection_Homo sapiens_hsa051691.12945600
49Tyrosine metabolism_Homo sapiens_hsa003501.12211376
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11665707
51Vitamin digestion and absorption_Homo sapiens_hsa049771.10111840
52Purine metabolism_Homo sapiens_hsa002301.05737461
53Allograft rejection_Homo sapiens_hsa053301.03098739
54mRNA surveillance pathway_Homo sapiens_hsa030151.01473497
55Hematopoietic cell lineage_Homo sapiens_hsa046401.00976012
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99869947
57Type I diabetes mellitus_Homo sapiens_hsa049400.98378623
58Alzheimers disease_Homo sapiens_hsa050100.97659103
59Graft-versus-host disease_Homo sapiens_hsa053320.93458520
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.91592156
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90970589
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90465861
63Vitamin B6 metabolism_Homo sapiens_hsa007500.89628575
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89046877
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83418620
66Thyroid cancer_Homo sapiens_hsa052160.83020710
67Mineral absorption_Homo sapiens_hsa049780.82862500
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82559906
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80882571
70T cell receptor signaling pathway_Homo sapiens_hsa046600.80772907
71Viral myocarditis_Homo sapiens_hsa054160.80513260
72Tight junction_Homo sapiens_hsa045300.78925674
73Rheumatoid arthritis_Homo sapiens_hsa053230.78750990
74Osteoclast differentiation_Homo sapiens_hsa043800.77568559
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75842969
76Linoleic acid metabolism_Homo sapiens_hsa005910.75497547
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74996399
78Phototransduction_Homo sapiens_hsa047440.74930552
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72052732
80Asthma_Homo sapiens_hsa053100.70785504
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70488237
82Vibrio cholerae infection_Homo sapiens_hsa051100.69555322
83Influenza A_Homo sapiens_hsa051640.68624317
84Apoptosis_Homo sapiens_hsa042100.68245468
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67099713
86HTLV-I infection_Homo sapiens_hsa051660.67084640
87Colorectal cancer_Homo sapiens_hsa052100.66478644
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66423270
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66012441
90Leishmaniasis_Homo sapiens_hsa051400.65905688
91Caffeine metabolism_Homo sapiens_hsa002320.64482575
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64414512
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63942323
94N-Glycan biosynthesis_Homo sapiens_hsa005100.63881011
95Phagosome_Homo sapiens_hsa041450.60651460
96Nitrogen metabolism_Homo sapiens_hsa009100.59968080
97Shigellosis_Homo sapiens_hsa051310.59051932
98Huntingtons disease_Homo sapiens_hsa050160.56586190
99Fatty acid elongation_Homo sapiens_hsa000620.56507337
100Endocytosis_Homo sapiens_hsa041440.56439419
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54773857
102Pentose phosphate pathway_Homo sapiens_hsa000300.54187259
103TNF signaling pathway_Homo sapiens_hsa046680.54140549
104Pertussis_Homo sapiens_hsa051330.53928385
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.53115174
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52605953
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52581189
108Acute myeloid leukemia_Homo sapiens_hsa052210.51185136
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50375885
110Salmonella infection_Homo sapiens_hsa051320.48594633
111B cell receptor signaling pathway_Homo sapiens_hsa046620.48339681
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48247512
113Hepatitis B_Homo sapiens_hsa051610.47991471
114Other glycan degradation_Homo sapiens_hsa005110.47889921
115Ether lipid metabolism_Homo sapiens_hsa005650.46440235
116Regulation of autophagy_Homo sapiens_hsa041400.45751089
117Oxidative phosphorylation_Homo sapiens_hsa001900.44863422
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44737965
119beta-Alanine metabolism_Homo sapiens_hsa004100.44595323
120Staphylococcus aureus infection_Homo sapiens_hsa051500.43219553
121Starch and sucrose metabolism_Homo sapiens_hsa005000.40935594
122Glutathione metabolism_Homo sapiens_hsa004800.40485085
123Autoimmune thyroid disease_Homo sapiens_hsa053200.39546178
124Tuberculosis_Homo sapiens_hsa051520.38528949
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.38187295
126Adherens junction_Homo sapiens_hsa045200.38156113
127Basal cell carcinoma_Homo sapiens_hsa052170.35643228
128Pancreatic cancer_Homo sapiens_hsa052120.32765339
129Viral carcinogenesis_Homo sapiens_hsa052030.32752600
130Parkinsons disease_Homo sapiens_hsa050120.31731593
131Retinol metabolism_Homo sapiens_hsa008300.29508495
132Hepatitis C_Homo sapiens_hsa051600.29293627
133Metabolic pathways_Homo sapiens_hsa011000.26073973
134Toxoplasmosis_Homo sapiens_hsa051450.25630321
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.25473568
136Peroxisome_Homo sapiens_hsa041460.23180258
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21704406
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21534549
139Endometrial cancer_Homo sapiens_hsa052130.20548881
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20504595
141Small cell lung cancer_Homo sapiens_hsa052220.20431572
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19762338
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19352839

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