ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	respiratory chain complex IV assembly (GO:0008535)	4.92345461
2	regulation of memory T cell differentiation (GO:0043380)	4.83186854
3	cytochrome complex assembly (GO:0017004)	4.27887628
4	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.11376651
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.04003431
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.86458259
7	proteasome assembly (GO:0043248)	3.78611643
8	protein localization to cilium (GO:0061512)	3.73719093
9	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.67896227
10	DNA deamination (GO:0045006)	3.66879791
11	magnesium ion transport (GO:0015693)	3.66634943
12	protein complex biogenesis (GO:0070271)	3.66322239
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.56535058
14	rRNA modification (GO:0000154)	3.49319905
15	rRNA methylation (GO:0031167)	3.44580702
16	regulation of hexokinase activity (GO:1903299)	3.44448451
17	regulation of glucokinase activity (GO:0033131)	3.44448451
18	mitochondrial respiratory chain complex assembly (GO:0033108)	3.44236207
19	cellular ketone body metabolic process (GO:0046950)	3.42668521
20	ketone body metabolic process (GO:1902224)	3.42659195
21	signal peptide processing (GO:0006465)	3.42320260
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39443454
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39443454
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35323334
25	mannosylation (GO:0097502)	3.30379187
26	electron transport chain (GO:0022900)	3.28220527
27	respiratory electron transport chain (GO:0022904)	3.27816455
28	platelet dense granule organization (GO:0060155)	3.25258241
29	inositol phosphate catabolic process (GO:0071545)	3.23190756
30	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.20953695
31	polyol catabolic process (GO:0046174)	3.17459371
32	peptidyl-histidine modification (GO:0018202)	3.16830268
33	ATP synthesis coupled proton transport (GO:0015986)	3.16462545
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.16462545
35	keratinocyte development (GO:0003334)	3.13730178
36	molting cycle (GO:0042303)	3.13426055
37	hair cycle (GO:0042633)	3.13426055
38	C-terminal protein lipidation (GO:0006501)	3.12108115
39	inositol phosphate dephosphorylation (GO:0046855)	3.10863139
40	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.10863139
41	AMP metabolic process (GO:0046033)	3.06491469
42	protein K6-linked ubiquitination (GO:0085020)	3.06438752
43	protein neddylation (GO:0045116)	3.05789303
44	pseudouridine synthesis (GO:0001522)	3.05005415
45	dopamine transport (GO:0015872)	2.98403479
46	ADP metabolic process (GO:0046031)	2.96804173
47	regulation of activation of Janus kinase activity (GO:0010533)	2.95878493
48	nucleotide transmembrane transport (GO:1901679)	2.95236410
49	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94360463
50	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.94056394
51	isotype switching (GO:0045190)	2.94056394
52	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.94056394
53	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.92555006
54	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.92242910
55	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.91082646
56	positive regulation of glycolytic process (GO:0045821)	2.90327722
57	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.89249805
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87553204
59	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87553204
60	NADH dehydrogenase complex assembly (GO:0010257)	2.87553204
61	protein-cofactor linkage (GO:0018065)	2.85754894
62	branched-chain amino acid catabolic process (GO:0009083)	2.83929147
63	GPI anchor metabolic process (GO:0006505)	2.81659896
64	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.80801314
65	replication fork processing (GO:0031297)	2.79902438
66	GPI anchor biosynthetic process (GO:0006506)	2.78385982
67	adenosine metabolic process (GO:0046085)	2.78091155
68	positive regulation of cell fate commitment (GO:0010455)	2.76513049
69	C-terminal protein amino acid modification (GO:0018410)	2.75057804
70	lactate metabolic process (GO:0006089)	2.73137472
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.70490247
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.70002338
73	mitochondrial DNA replication (GO:0006264)	2.69632893
74	DNA double-strand break processing (GO:0000729)	2.65768165
75	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.64922915
76	protein deneddylation (GO:0000338)	2.64176338
77	regulation of cellular amino acid metabolic process (GO:0006521)	2.63691019
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.62189309
79	pteridine-containing compound biosynthetic process (GO:0042559)	2.62005672
80	regulation of cilium movement (GO:0003352)	2.61494228
81	tRNA processing (GO:0008033)	2.60608969
82	prenylation (GO:0097354)	2.60092745
83	protein prenylation (GO:0018342)	2.60092745
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.58454488
85	purine nucleobase biosynthetic process (GO:0009113)	2.57753267
86	piRNA metabolic process (GO:0034587)	2.56932267
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55649315
88	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.55472784
89	mitochondrial RNA metabolic process (GO:0000959)	2.55219671
90	cullin deneddylation (GO:0010388)	2.54593332
91	negative regulation of neurological system process (GO:0031645)	2.54349223
92	nucleoside diphosphate phosphorylation (GO:0006165)	2.52295099
93	tRNA metabolic process (GO:0006399)	2.52130743
94	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.49699580
95	response to pheromone (GO:0019236)	2.49602827
96	succinate metabolic process (GO:0006105)	2.48712237
97	proton transport (GO:0015992)	2.48658623
98	L-fucose catabolic process (GO:0042355)	2.46813431
99	fucose catabolic process (GO:0019317)	2.46813431
100	L-fucose metabolic process (GO:0042354)	2.46813431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91981320
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47710584
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.34948444
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.33097131
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01606268
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83662424
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78282716
8	VDR_22108803_ChIP-Seq_LS180_Human	2.77445304
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.74318499
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72863725
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.50975587
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.28720500
13	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.19208986
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17799720
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05377298
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02989035
17	FUS_26573619_Chip-Seq_HEK293_Human	2.00895451
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00259882
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.92540014
20	EWS_26573619_Chip-Seq_HEK293_Human	1.89507659
21	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.86876459
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.85794396
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.85405055
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83998915
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.74013147
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73062905
27	P300_19829295_ChIP-Seq_ESCs_Human	1.66721303
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63290362
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61295710
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.58756514
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56425924
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.54994802
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54986199
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54012521
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53655765
36	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.51331561
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.48610704
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45123865
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41210789
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40785602
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40785602
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39591736
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39520031
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39002732
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35802505
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35802505
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.35118974
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35046901
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34930321
50	HTT_18923047_ChIP-ChIP_STHdh_Human	1.34046193
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33809660
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32478285
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31851439
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27816627
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27044091
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26362141
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25346914
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24993005
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.24789094
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24789094
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20406051
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20019072
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19138109
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15057857
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14722720
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14385045
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.14381008
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13876755
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.12791238
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11715988
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11485805
72	AR_25329375_ChIP-Seq_VCAP_Human	1.11288956
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10888527
74	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09918725
75	AR_20517297_ChIP-Seq_VCAP_Human	1.08169652
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.07491633
77	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06136561
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03606885
79	STAT3_23295773_ChIP-Seq_U87_Human	1.03478937
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02263137
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01935567
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01850226
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01323827
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00250632
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00142070
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99077569
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98830052
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.98377726
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96906260
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96265798
91	TCF4_23295773_ChIP-Seq_U87_Human	0.95632069
92	NCOR_22424771_ChIP-Seq_293T_Human	0.94047037
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92662002
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92186882
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92093723
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90885175
97	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89306679
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88264150
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.88256073
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.87933136

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.67542070
2	MP0002837_dystrophic_cardiac_calcinosis	3.05026038
3	MP0004147_increased_porphyrin_level	2.92512759
4	MP0003806_abnormal_nucleotide_metabolis	2.91413116
5	MP0002638_abnormal_pupillary_reflex	2.65379940
6	MP0005075_abnormal_melanosome_morpholog	2.58990840
7	MP0005379_endocrine/exocrine_gland_phen	2.48251080
8	MP0002102_abnormal_ear_morphology	2.34624198
9	MP0004043_abnormal_pH_regulation	2.26314847
10	MP0009780_abnormal_chondrocyte_physiolo	2.24882466
11	MP0000569_abnormal_digit_pigmentation	2.20184931
12	MP0008875_abnormal_xenobiotic_pharmacok	2.14303068
13	MP0005084_abnormal_gallbladder_morpholo	2.11289532
14	MP0003786_premature_aging	2.08222491
15	MP0008877_abnormal_DNA_methylation	2.00512177
16	MP0000647_abnormal_sebaceous_gland	1.94494416
17	MP0008058_abnormal_DNA_repair	1.94431881
18	MP0002160_abnormal_reproductive_system	1.92271025
19	MP0002163_abnormal_gland_morphology	1.89387611
20	MP0005389_reproductive_system_phenotype	1.87492543
21	MP0006072_abnormal_retinal_apoptosis	1.86300478
22	MP0003950_abnormal_plasma_membrane	1.84847860
23	MP0009697_abnormal_copulation	1.84409804
24	MP0000427_abnormal_hair_cycle	1.82980804
25	MP0002876_abnormal_thyroid_physiology	1.82535160
26	MP0005408_hypopigmentation	1.82133722
27	MP0005332_abnormal_amino_acid	1.75205497
28	MP0005645_abnormal_hypothalamus_physiol	1.74502706
29	MP0008057_abnormal_DNA_replication	1.69145360
30	MP0005551_abnormal_eye_electrophysiolog	1.68725129
31	MP0010678_abnormal_skin_adnexa	1.67618788
32	MP0002693_abnormal_pancreas_physiology	1.67374365
33	MP0002938_white_spotting	1.65955030
34	MP0000013_abnormal_adipose_tissue	1.63606017
35	MP0009046_muscle_twitch	1.61000190
36	MP0000372_irregular_coat_pigmentation	1.60021602
37	MP0000383_abnormal_hair_follicle	1.54706073
38	MP0001764_abnormal_homeostasis	1.54639937
39	MP0006036_abnormal_mitochondrial_physio	1.53777310
40	MP0005646_abnormal_pituitary_gland	1.51671711
41	MP0010386_abnormal_urinary_bladder	1.44215974
42	MP0001919_abnormal_reproductive_system	1.42127697
43	MP0004142_abnormal_muscle_tone	1.42089457
44	MP0003880_abnormal_central_pattern	1.39682805
45	MP0006276_abnormal_autonomic_nervous	1.34045315
46	MP0002234_abnormal_pharynx_morphology	1.34036195
47	MP0002928_abnormal_bile_duct	1.31739342
48	MP0001944_abnormal_pancreas_morphology	1.30396603
49	MP0005253_abnormal_eye_physiology	1.27789338
50	MP0008775_abnormal_heart_ventricle	1.27280889
51	MP0003186_abnormal_redox_activity	1.26633671
52	MP0002822_catalepsy	1.23558423
53	MP0003011_delayed_dark_adaptation	1.23492232
54	MP0005187_abnormal_penis_morphology	1.19832817
55	MP0010234_abnormal_vibrissa_follicle	1.17387657
56	MP0008995_early_reproductive_senescence	1.16475852
57	MP0010094_abnormal_chromosome_stability	1.14851625
58	MP0002090_abnormal_vision	1.13132086
59	MP0005174_abnormal_tail_pigmentation	1.11925285
60	MP0005248_abnormal_Harderian_gland	1.11200840
61	MP0006035_abnormal_mitochondrial_morpho	1.08760003
62	MP0001529_abnormal_vocalization	1.07656600
63	MP0001986_abnormal_taste_sensitivity	1.06212951
64	MP0004133_heterotaxia	1.05827042
65	MP0000358_abnormal_cell_content/	1.05396717
66	MP0008872_abnormal_physiological_respon	1.05144646
67	MP0001984_abnormal_olfaction	1.04542400
68	MP0006054_spinal_hemorrhage	1.01363907
69	MP0001905_abnormal_dopamine_level	1.01321140
70	MP0001929_abnormal_gametogenesis	1.00879843
71	MP0004215_abnormal_myocardial_fiber	1.00097449
72	MP0002254_reproductive_system_inflammat	0.95938632
73	MP0003283_abnormal_digestive_organ	0.94091934
74	MP0001661_extended_life_span	0.91275920
75	MP0005636_abnormal_mineral_homeostasis	0.90852604
76	MP0003252_abnormal_bile_duct	0.88205864
77	MP0001756_abnormal_urination	0.87838184
78	MP0001765_abnormal_ion_homeostasis	0.85519962
79	MP0000613_abnormal_salivary_gland	0.84372143
80	MP0010329_abnormal_lipoprotein_level	0.83160678
81	MP0003718_maternal_effect	0.83114830
82	MP0000653_abnormal_sex_gland	0.80581787
83	MP0005220_abnormal_exocrine_pancreas	0.80524714
84	MP0008007_abnormal_cellular_replicative	0.80388199
85	MP0005171_absent_coat_pigmentation	0.80288788
86	MP0002078_abnormal_glucose_homeostasis	0.77224535
87	MP0002210_abnormal_sex_determination	0.76606760
88	MP0005367_renal/urinary_system_phenotyp	0.76507817
89	MP0000516_abnormal_urinary_system	0.76507817
90	MP0009643_abnormal_urine_homeostasis	0.75145554
91	MP0002272_abnormal_nervous_system	0.74320801
92	MP0003943_abnormal_hepatobiliary_system	0.72726725
93	MP0004885_abnormal_endolymph	0.71846003
94	MP0001485_abnormal_pinna_reflex	0.71181315
95	MP0005410_abnormal_fertilization	0.71049418
96	MP0003698_abnormal_male_reproductive	0.70652163
97	MP0002909_abnormal_adrenal_gland	0.70035460
98	MP0001324_abnormal_eye_pigmentation	0.69217936
99	MP0000639_abnormal_adrenal_gland	0.68736833
100	MP0002095_abnormal_skin_pigmentation	0.68043223

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	3.71719265
2	Pancreatic cysts (HP:0001737)	3.68216780
3	Acute necrotizing encephalopathy (HP:0006965)	3.67565055
4	Hepatic necrosis (HP:0002605)	3.60389357
5	Hepatocellular necrosis (HP:0001404)	3.59605921
6	Increased CSF lactate (HP:0002490)	3.59033819
7	Progressive macrocephaly (HP:0004481)	3.53494099
8	Hypoglycemic coma (HP:0001325)	3.39286123
9	Hypothermia (HP:0002045)	3.38697074
10	Increased hepatocellular lipid droplets (HP:0006565)	3.37428649
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.36988376
12	Medial flaring of the eyebrow (HP:0010747)	3.36259969
13	Large for gestational age (HP:0001520)	3.31007208
14	Renal cortical cysts (HP:0000803)	3.29860053
15	Lipid accumulation in hepatocytes (HP:0006561)	3.19259692
16	Abnormality of methionine metabolism (HP:0010901)	3.11703109
17	Acute encephalopathy (HP:0006846)	3.10438752
18	Hypoglycemic seizures (HP:0002173)	3.08504888
19	Methylmalonic acidemia (HP:0002912)	3.05022080
20	Pancreatic fibrosis (HP:0100732)	3.01622845
21	Hyperinsulinemic hypoglycemia (HP:0000825)	3.00796491
22	Ketoacidosis (HP:0001993)	3.00413778
23	True hermaphroditism (HP:0010459)	2.99759569
24	Congenital primary aphakia (HP:0007707)	2.88480169
25	Renal Fanconi syndrome (HP:0001994)	2.87706359
26	Abnormality of the renal cortex (HP:0011035)	2.86500897
27	Molar tooth sign on MRI (HP:0002419)	2.83531350
28	Abnormality of midbrain morphology (HP:0002418)	2.83531350
29	Gait imbalance (HP:0002141)	2.77237547
30	Nephrogenic diabetes insipidus (HP:0009806)	2.74599291
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.65952214
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.65952214
33	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.64886536
34	Nephronophthisis (HP:0000090)	2.62663387
35	Increased serum lactate (HP:0002151)	2.55714568
36	Cerebral edema (HP:0002181)	2.47560081
37	3-Methylglutaconic aciduria (HP:0003535)	2.44707597
38	Neuroendocrine neoplasm (HP:0100634)	2.42955089
39	Abnormality of vitamin B metabolism (HP:0004340)	2.41503883
40	Conjunctival hamartoma (HP:0100780)	2.32058308
41	Hypomagnesemia (HP:0002917)	2.31000587
42	Lactic acidosis (HP:0003128)	2.29306374
43	Type I transferrin isoform profile (HP:0003642)	2.27697503
44	Pheochromocytoma (HP:0002666)	2.25920434
45	Methylmalonic aciduria (HP:0012120)	2.25106624
46	Type II lissencephaly (HP:0007260)	2.23154807
47	Furrowed tongue (HP:0000221)	2.22637160
48	Respiratory failure (HP:0002878)	2.19981287
49	Pancreatic islet-cell hyperplasia (HP:0004510)	2.14968044
50	Symptomatic seizures (HP:0011145)	2.14868485
51	Abnormality of the renal medulla (HP:0100957)	2.13089618
52	Genital tract atresia (HP:0001827)	2.11470630
53	Hyperglycemia (HP:0003074)	2.11201192
54	Abnormal protein glycosylation (HP:0012346)	2.08598096
55	Abnormal glycosylation (HP:0012345)	2.08598096
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.08598096
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.08598096
58	Meningioma (HP:0002858)	2.05761119
59	Optic disc pallor (HP:0000543)	2.05126861
60	Palpitations (HP:0001962)	2.05110605
61	Short tibia (HP:0005736)	2.04400703
62	Abnormality of the pons (HP:0007361)	2.02782350
63	Abnormal drinking behavior (HP:0030082)	2.01526085
64	Polydipsia (HP:0001959)	2.01526085
65	Congenital, generalized hypertrichosis (HP:0004540)	2.00250791
66	Generalized aminoaciduria (HP:0002909)	1.98782268
67	Patchy hypopigmentation of hair (HP:0011365)	1.98651413
68	Increased intramyocellular lipid droplets (HP:0012240)	1.98038676
69	Aplasia/hypoplasia of the uterus (HP:0008684)	1.96700981
70	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96531990
71	Abnormality of alanine metabolism (HP:0010916)	1.96531990
72	Hyperalaninemia (HP:0003348)	1.96531990
73	Vaginal atresia (HP:0000148)	1.95302015
74	Exertional dyspnea (HP:0002875)	1.94411369
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93473690
76	Abnormality of endocrine pancreas physiology (HP:0012093)	1.92753778
77	Abnormality of the pancreatic islet cells (HP:0006476)	1.92753778
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92301151
79	Progressive inability to walk (HP:0002505)	1.91977119
80	Hypoplasia of the pons (HP:0012110)	1.91165996
81	Neoplasm of the adrenal gland (HP:0100631)	1.90164515
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90015315
83	Lethargy (HP:0001254)	1.89813232
84	Hamartoma of the eye (HP:0010568)	1.89048236
85	Cerebellar dysplasia (HP:0007033)	1.88765673
86	Abnormal biliary tract physiology (HP:0012439)	1.88610021
87	Bile duct proliferation (HP:0001408)	1.88610021
88	Sclerocornea (HP:0000647)	1.87616011
89	Abnormality of urine glucose concentration (HP:0011016)	1.87612918
90	Glycosuria (HP:0003076)	1.87612918
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86545647
92	Congenital stationary night blindness (HP:0007642)	1.85543697
93	Abnormality of renal resorption (HP:0011038)	1.83908343
94	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.82297050
95	Male pseudohermaphroditism (HP:0000037)	1.80833658
96	Ketosis (HP:0001946)	1.80065879
97	Muscular hypotonia of the trunk (HP:0008936)	1.79768626
98	Attenuation of retinal blood vessels (HP:0007843)	1.79324465
99	CNS demyelination (HP:0007305)	1.79107993
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78084940

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.53723979
2	MST4	4.40526458
3	EIF2AK3	3.29829198
4	TRIM28	3.24760727
5	ZAK	2.42037213
6	BMPR1B	2.30399442
7	ERBB3	2.09477181
8	GRK1	1.98137556
9	WNK3	1.97253747
10	MAP4K2	1.93953020
11	EPHA3	1.69868123
12	STK39	1.64448337
13	NEK1	1.58244268
14	WNK4	1.57946553
15	STK16	1.56712623
16	PHKG1	1.55626110
17	PHKG2	1.55626110
18	OXSR1	1.49984324
19	SRPK1	1.49766978
20	MAP3K12	1.46439967
21	EIF2AK1	1.43067431
22	PLK2	1.40430949
23	FER	1.38709977
24	ADRBK2	1.37833263
25	BRSK2	1.37491674
26	STK3	1.35149395
27	PAK3	1.35103487
28	PLK3	1.34348931
29	VRK2	1.33886594
30	BUB1	1.27577928
31	ACVR1B	1.25963494
32	CSNK1G1	1.24742945
33	CSNK1G3	1.23192154
34	SIK3	1.20982741
35	CAMKK2	1.18965319
36	NUAK1	1.17413225
37	BCR	1.15443852
38	FGFR2	1.15138873
39	VRK1	1.13393648
40	TXK	1.12366136
41	LIMK1	1.08707911
42	PASK	1.05046371
43	CSNK1G2	1.02321555
44	MAP3K13	0.98811529
45	PINK1	0.95137422
46	MET	0.93241829
47	PRKCE	0.92973646
48	MAPK13	0.91933808
49	TSSK6	0.91243325
50	NME1	0.91215688
51	MAP3K4	0.88242998
52	STK4	0.85109258
53	MUSK	0.84360979
54	IKBKB	0.84001513
55	EIF2AK2	0.83619664
56	CSNK1A1L	0.83175230
57	TRPM7	0.82887085
58	BMPR2	0.81553595
59	MKNK2	0.81177915
60	INSRR	0.81170241
61	STK38L	0.80279364
62	WEE1	0.79497670
63	NEK9	0.74321117
64	MAPKAPK3	0.73136660
65	CDK3	0.72847524
66	MAPKAPK5	0.71654827
67	BCKDK	0.71099667
68	FLT3	0.70333782
69	PLK1	0.70140996
70	TEC	0.68552248
71	PRKCI	0.67198396
72	MKNK1	0.66049932
73	TLK1	0.65260630
74	TGFBR1	0.64330720
75	MYLK	0.60479973
76	CHUK	0.60118299
77	PBK	0.56258179
78	ADRBK1	0.54865980
79	RPS6KA5	0.54255491
80	PRKCG	0.53823790
81	MAP2K6	0.52550639
82	TTK	0.49209914
83	PRKAA2	0.49083942
84	TIE1	0.48230403
85	ERBB4	0.44535411
86	TAOK3	0.43369688
87	NLK	0.42469981
88	PDK2	0.42376318
89	CSNK1A1	0.41163950
90	RPS6KA4	0.40281965
91	ATM	0.38235054
92	IRAK1	0.36194400
93	ATR	0.35761144
94	ABL1	0.35081852
95	PTK2B	0.34787293
96	MAP3K2	0.34185305
97	CAMK2D	0.30398896
98	PIM2	0.30368291
99	PRKAA1	0.28808393
100	MST1R	0.27778860

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.26832439
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.30677888
3	Proteasome_Homo sapiens_hsa03050	3.21945145
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.01324048
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.69672570
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.53692553
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.48442746
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34583333
9	Parkinsons disease_Homo sapiens_hsa05012	2.30228117
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.28995976
11	Sulfur metabolism_Homo sapiens_hsa00920	2.27263169
12	Propanoate metabolism_Homo sapiens_hsa00640	2.15723075
13	One carbon pool by folate_Homo sapiens_hsa00670	1.96077693
14	Basal transcription factors_Homo sapiens_hsa03022	1.94926297
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.92996464
16	Homologous recombination_Homo sapiens_hsa03440	1.89082658
17	Butanoate metabolism_Homo sapiens_hsa00650	1.86719506
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86237562
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81419401
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80724027
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.65036672
22	RNA polymerase_Homo sapiens_hsa03020	1.60629737
23	Alzheimers disease_Homo sapiens_hsa05010	1.55496767
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.53887643
25	RNA degradation_Homo sapiens_hsa03018	1.50487594
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46665911
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45537918
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.41851016
29	Regulation of autophagy_Homo sapiens_hsa04140	1.41704563
30	Huntingtons disease_Homo sapiens_hsa05016	1.40918582
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40058327
32	Fatty acid elongation_Homo sapiens_hsa00062	1.36222914
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.33419188
34	Peroxisome_Homo sapiens_hsa04146	1.30942080
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28778033
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.27789869
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21312399
38	Folate biosynthesis_Homo sapiens_hsa00790	1.19872115
39	Phototransduction_Homo sapiens_hsa04744	1.19210945
40	Mismatch repair_Homo sapiens_hsa03430	1.18755577
41	Circadian rhythm_Homo sapiens_hsa04710	1.12380905
42	Purine metabolism_Homo sapiens_hsa00230	1.12117840
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10352863
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04796426
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97096043
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95669136
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95592033
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.87082331
49	Insulin secretion_Homo sapiens_hsa04911	0.86675470
50	Metabolic pathways_Homo sapiens_hsa01100	0.85455595
51	RNA transport_Homo sapiens_hsa03013	0.85220009
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84674814
53	Glutathione metabolism_Homo sapiens_hsa00480	0.83908194
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83220267
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82669305
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82140443
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80757357
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79543039
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75411255
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75381215
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.74189993
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72453456
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71837758
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70962040
65	Caffeine metabolism_Homo sapiens_hsa00232	0.68195525
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.63828004
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.63367829
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.62769207
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60806755
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60747530
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59973153
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57344297
73	Retinol metabolism_Homo sapiens_hsa00830	0.55602392
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55062213
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53864426
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53692191
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53326248
78	p53 signaling pathway_Homo sapiens_hsa04115	0.50773594
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50547219
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50152649
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48727767
82	ABC transporters_Homo sapiens_hsa02010	0.48601562
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48436597
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48269882
85	DNA replication_Homo sapiens_hsa03030	0.47624366
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47319711
87	Mineral absorption_Homo sapiens_hsa04978	0.44743207
88	Spliceosome_Homo sapiens_hsa03040	0.42794248
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41085312
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40571313
91	Olfactory transduction_Homo sapiens_hsa04740	0.34962006
92	Taste transduction_Homo sapiens_hsa04742	0.33724627
93	Oocyte meiosis_Homo sapiens_hsa04114	0.33098388
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.32813730
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30643191
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25828315
97	Fatty acid degradation_Homo sapiens_hsa00071	0.23785823
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22288124
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.22117855
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.21900107

TMEM267

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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