TMEM27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.16013044
2Golgi transport vesicle coating (GO:0048200)9.16013044
3endocrine pancreas development (GO:0031018)6.13316089
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.05938350
5peptide hormone processing (GO:0016486)5.99187299
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.75104089
7COPII vesicle coating (GO:0048208)5.44335407
8protein retention in ER lumen (GO:0006621)5.41514956
9drug transmembrane transport (GO:0006855)5.40726404
10signal peptide processing (GO:0006465)4.94568269
11glandular epithelial cell differentiation (GO:0002067)4.82382471
12toxin metabolic process (GO:0009404)4.81344814
13cellular response to vitamin D (GO:0071305)4.80703866
14L-alpha-amino acid transmembrane transport (GO:1902475)4.77214829
15* positive regulation of insulin secretion (GO:0032024)4.71562070
16urate metabolic process (GO:0046415)4.63370232
17cellular ketone body metabolic process (GO:0046950)4.59046613
18sequestering of metal ion (GO:0051238)4.46213859
19S-adenosylmethionine metabolic process (GO:0046500)4.46202443
20organic cation transport (GO:0015695)4.39376133
21insulin secretion (GO:0030073)4.37989845
22L-phenylalanine catabolic process (GO:0006559)4.31902211
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.31902211
24aromatic amino acid family catabolic process (GO:0009074)4.27232295
25amino-acid betaine metabolic process (GO:0006577)4.16815453
26drug catabolic process (GO:0042737)4.16671518
27drug transport (GO:0015893)4.15667261
28ketone body metabolic process (GO:1902224)4.10704605
29toxin transport (GO:1901998)4.09563047
30tricarboxylic acid metabolic process (GO:0072350)4.09342941
31glandular epithelial cell development (GO:0002068)4.06429376
32vesicle coating (GO:0006901)4.04574223
33phenylpropanoid metabolic process (GO:0009698)4.03533996
34negative regulation of execution phase of apoptosis (GO:1900118)4.02189798
35exogenous drug catabolic process (GO:0042738)3.99812839
36epoxygenase P450 pathway (GO:0019373)3.99074318
37L-phenylalanine metabolic process (GO:0006558)3.97272287
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97272287
39aminoglycoside antibiotic metabolic process (GO:0030647)3.96929796
40cellular glucuronidation (GO:0052695)3.96449397
41regulation of fibrinolysis (GO:0051917)3.94118056
42protein maturation by protein folding (GO:0022417)3.93051339
43glyoxylate metabolic process (GO:0046487)3.87511946
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.86982682
45metanephric tubule development (GO:0072170)3.83526337
46metanephric nephron tubule development (GO:0072234)3.83526337
47renal absorption (GO:0070293)3.82984175
48type B pancreatic cell development (GO:0003323)3.81325991
49glucuronate metabolic process (GO:0019585)3.81128218
50uronic acid metabolic process (GO:0006063)3.81128218
51* regulation of insulin secretion (GO:0050796)3.80769029
52phosphate ion transport (GO:0006817)3.76496734
53regulation of type B pancreatic cell apoptotic process (GO:2000674)3.75287853
54* positive regulation of peptide hormone secretion (GO:0090277)3.75170873
55peptide catabolic process (GO:0043171)3.74958412
56negative regulation of JUN kinase activity (GO:0043508)3.71150626
57inositol phosphate catabolic process (GO:0071545)3.68442543
58positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.66131554
59inositol phosphate dephosphorylation (GO:0046855)3.66007756
60phosphorylated carbohydrate dephosphorylation (GO:0046838)3.66007756
61negative regulation of digestive system process (GO:0060457)3.65356528
62peptide hormone secretion (GO:0030072)3.64478902
63positive regulation of nuclease activity (GO:0032075)3.63804707
64xenobiotic catabolic process (GO:0042178)3.60951715
65* positive regulation of peptide secretion (GO:0002793)3.59688176
66glycerophospholipid catabolic process (GO:0046475)3.55314744
67peptide secretion (GO:0002790)3.54656824
68regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.48898838
69* regulation of peptide hormone secretion (GO:0090276)3.44434709
70peptide metabolic process (GO:0006518)3.41517193
71lysine metabolic process (GO:0006553)3.40695622
72lysine catabolic process (GO:0006554)3.40695622
73metanephric nephron epithelium development (GO:0072243)3.40354388
74cellular response to vitamin (GO:0071295)3.39809164
75bile acid biosynthetic process (GO:0006699)3.37836886
76* regulation of peptide secretion (GO:0002791)3.36968167
77regulation of protein activation cascade (GO:2000257)3.36556952
78omega-hydroxylase P450 pathway (GO:0097267)3.36434437
79excretion (GO:0007588)3.36399052
80intra-Golgi vesicle-mediated transport (GO:0006891)3.35351861
81epithelial cell fate commitment (GO:0072148)3.35323127
82ER to Golgi vesicle-mediated transport (GO:0006888)3.33860183
83ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.33801950
84protein autoprocessing (GO:0016540)3.31634692
85macroautophagy (GO:0016236)3.31370660
86regulation of nuclease activity (GO:0032069)3.29899446
87ethanol oxidation (GO:0006069)3.29295695
88beta-amyloid metabolic process (GO:0050435)3.28145308
89acylglycerol homeostasis (GO:0055090)3.26982901
90triglyceride homeostasis (GO:0070328)3.26982901
91tyrosine metabolic process (GO:0006570)3.26478449
92nephron epithelium morphogenesis (GO:0072088)3.25154709
93nephron tubule morphogenesis (GO:0072078)3.25154709
94ER overload response (GO:0006983)3.24853248
95polyol catabolic process (GO:0046174)3.23307759
96water-soluble vitamin biosynthetic process (GO:0042364)3.23189149
97oxidative demethylation (GO:0070989)3.23070282
98exocrine pancreas development (GO:0031017)3.21921976
99astrocyte differentiation (GO:0048708)3.20897922
100aldehyde catabolic process (GO:0046185)3.20360395
101regulation of complement activation (GO:0030449)3.19606215
102endoplasmic reticulum unfolded protein response (GO:0030968)3.16420795
103polyketide metabolic process (GO:0030638)3.15112831
104doxorubicin metabolic process (GO:0044598)3.15112831
105daunorubicin metabolic process (GO:0044597)3.15112831
106negative regulation of sterol transport (GO:0032372)3.14822287
107negative regulation of cholesterol transport (GO:0032375)3.14822287
108fatty acid homeostasis (GO:0055089)3.14137398
109detection of calcium ion (GO:0005513)3.13543559
110cellular response to unfolded protein (GO:0034620)3.13249979
111hormone transport (GO:0009914)3.13102253
112response to dietary excess (GO:0002021)3.12843455
113cellular response to topologically incorrect protein (GO:0035967)3.12730861
114response to mercury ion (GO:0046689)3.11793908
115negative regulation of protein activation cascade (GO:2000258)3.09181955
116glycoside metabolic process (GO:0016137)3.08506761
117metanephric epithelium development (GO:0072207)3.08205790
118drug metabolic process (GO:0017144)3.07947804
119negative regulation of hormone metabolic process (GO:0032351)3.06351899
120peptide transport (GO:0015833)3.05772845
121columnar/cuboidal epithelial cell development (GO:0002066)3.05561516
122hormone secretion (GO:0046879)3.04569363
123growth hormone secretion (GO:0030252)3.04393094
124cellular zinc ion homeostasis (GO:0006882)3.03363025
125response to hepatocyte growth factor (GO:0035728)3.02558917
126cellular response to hepatocyte growth factor stimulus (GO:0035729)3.02558917
127aromatic amino acid family metabolic process (GO:0009072)3.02312296
128* regulation of hormone secretion (GO:0046883)2.99845699
129regulation of Golgi to plasma membrane protein transport (GO:0042996)2.97964899
130regulation of energy homeostasis (GO:2000505)2.97443365
131negative regulation of hormone biosynthetic process (GO:0032353)2.96869779
132negative regulation of glycoprotein biosynthetic process (GO:0010561)2.96018021
133reverse cholesterol transport (GO:0043691)2.95662437
134response to parathyroid hormone (GO:0071107)2.92980580
135positive regulation of gluconeogenesis (GO:0045722)2.92738506
136* positive regulation of hormone secretion (GO:0046887)2.92280021
137cellular response to glucagon stimulus (GO:0071377)2.92210915
138protein carboxylation (GO:0018214)2.91938498
139peptidyl-glutamic acid carboxylation (GO:0017187)2.91938498
140ER-nucleus signaling pathway (GO:0006984)2.91858948
141branched-chain amino acid catabolic process (GO:0009083)2.90759619
142heme transport (GO:0015886)2.90637043
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90006622
144protein N-linked glycosylation via asparagine (GO:0018279)2.89762174
145proline metabolic process (GO:0006560)2.89729201
146glycine transport (GO:0015816)2.89491591
147positive regulation of glycolytic process (GO:0045821)2.89451676
148auditory receptor cell differentiation (GO:0042491)2.88669274
149peptidyl-asparagine modification (GO:0018196)2.87662452
150respiratory chain complex IV assembly (GO:0008535)2.87564446
151serine family amino acid catabolic process (GO:0009071)2.87454672
152fatty acid oxidation (GO:0019395)2.86803438
153lactate metabolic process (GO:0006089)2.86268283
154negative regulation of complement activation (GO:0045916)2.86130025
155positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.85199313
156positive regulation of calcium ion import (GO:0090280)2.83065568
157* positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.81702195
158regulation of hexokinase activity (GO:1903299)2.81594258
159regulation of glucokinase activity (GO:0033131)2.81594258
160lipid oxidation (GO:0034440)2.80328074
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80258754
162fatty acid beta-oxidation (GO:0006635)2.80015037
163magnesium ion transport (GO:0015693)2.79232624
164blood coagulation, intrinsic pathway (GO:0007597)2.78878949
165amino acid salvage (GO:0043102)2.78543035
166L-methionine salvage (GO:0071267)2.78543035
167L-methionine biosynthetic process (GO:0071265)2.78543035
168bile acid metabolic process (GO:0008206)2.77595714
169high-density lipoprotein particle remodeling (GO:0034375)2.73261505
170flavonoid metabolic process (GO:0009812)2.72628434
171alpha-amino acid catabolic process (GO:1901606)2.70504865
172cytochrome complex assembly (GO:0017004)2.70134862
173quaternary ammonium group transport (GO:0015697)2.69911822
174negative regulation of fibrinolysis (GO:0051918)2.69459806
175ethanol metabolic process (GO:0006067)2.67599425
176phosphate ion transmembrane transport (GO:0035435)2.65546167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81880113
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.73749589
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.03594783
4GATA1_22025678_ChIP-Seq_K562_Human2.58949777
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58722720
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.46764317
7GBX2_23144817_ChIP-Seq_PC3_Human2.42944938
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42684869
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.38832686
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11030326
11* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.09830534
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09454328
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.09101899
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01233479
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.3289521
16TAF15_26573619_Chip-Seq_HEK293_Human1.99742929
17HTT_18923047_ChIP-ChIP_STHdh_Human1.89234508
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.86995554
19VDR_22108803_ChIP-Seq_LS180_Human1.86185944
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85525371
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73772344
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.73310349
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71658090
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67570806
25P300_19829295_ChIP-Seq_ESCs_Human1.63740401
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59700656
27FUS_26573619_Chip-Seq_HEK293_Human1.58655137
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57871126
29SMAD4_21799915_ChIP-Seq_A2780_Human1.57620999
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56893505
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56794671
32IGF1R_20145208_ChIP-Seq_DFB_Human1.56683035
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52731436
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51778675
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51478668
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50719662
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50546863
38CDX2_22108803_ChIP-Seq_LS180_Human1.45721600
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.45556209
40BCAT_22108803_ChIP-Seq_LS180_Human1.45326017
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44016652
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43527595
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.42749820
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.42209999
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41592127
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40293244
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40156970
48CLOCK_20551151_ChIP-Seq_293T_Human1.39639323
49* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37889015
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36676450
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35936303
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.35716206
53CBP_20019798_ChIP-Seq_JUKART_Human1.34534944
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34534944
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.34235448
56* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33173176
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32544082
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32371727
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.32267192
60ER_23166858_ChIP-Seq_MCF-7_Human1.31574070
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31422371
62AR_25329375_ChIP-Seq_VCAP_Human1.30490656
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.29775740
64P53_22387025_ChIP-Seq_ESCs_Mouse1.29468979
65REST_19997604_ChIP-ChIP_NEURONS_Mouse1.27719965
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26618237
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25941706
68SOX2_19829295_ChIP-Seq_ESCs_Human1.25407671
69NANOG_19829295_ChIP-Seq_ESCs_Human1.25407671
70FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25387667
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.25263555
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25228902
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.24323900
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24299815
75TP53_22573176_ChIP-Seq_HFKS_Human1.22001899
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21681822
77TCF4_22108803_ChIP-Seq_LS180_Human1.20598435
78P300_18555785_Chip-Seq_ESCs_Mouse1.20533599
79SOX2_20726797_ChIP-Seq_SW620_Human1.20472559
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19789021
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19277711
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19239378
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18270279
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.18014432
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17674785
86GATA4_25053715_ChIP-Seq_YYC3_Human1.17190855
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.17138843
88TFEB_21752829_ChIP-Seq_HELA_Human1.17036052
89TCF4_23295773_ChIP-Seq_U87_Human1.16927778
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.16508025
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16492040
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16299491
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15283106
94* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13569697
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13263656
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.12946866
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12026575
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11804760
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.11459766
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09775605
101EWS_26573619_Chip-Seq_HEK293_Human1.09400441
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.09028373
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08787634
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08111906
105PHF8_20622853_ChIP-Seq_HELA_Human1.06836448
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06096249
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.05477339
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.05421098
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05315874
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04990597
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.04667588
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04563165
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03609437
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.02693318
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.02190324
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.01848624
117RUNX2_22187159_ChIP-Seq_PCA_Human1.01496075
118BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01163389
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99943778
120GABP_17652178_ChIP-ChIP_JURKAT_Human0.98926742
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98366414
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.97801129
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96198216
124ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90380404
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90031477
126GATA1_19941826_ChIP-Seq_K562_Human0.89837205
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89606085
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86713077
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86391096
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85769024
131ERG_20517297_ChIP-Seq_VCAP_Human0.85692281
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83856959
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83132292
134* AR_20517297_ChIP-Seq_VCAP_Human0.82590063
135STAT3_23295773_ChIP-Seq_U87_Human0.82365053
136MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81120564
137ZNF274_21170338_ChIP-Seq_K562_Hela0.80978010
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78926472
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78897402
140FOXA1_25329375_ChIP-Seq_VCAP_Human0.78897402
141HNF4A_19822575_ChIP-Seq_HepG2_Human0.78567452
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78295796
143GATA6_25053715_ChIP-Seq_YYC3_Human0.76890368
144REST_21632747_ChIP-Seq_MESCs_Mouse0.76705038
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.76395355
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75637969
147E2F1_17053090_ChIP-ChIP_MCF-7_Human0.75466041
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74925584
149CHD1_26751641_Chip-Seq_LNCaP_Human0.74756332
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73812072
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73320208
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72504637
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.72369112
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.68959473
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68264116
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.67905689
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67146634
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67108740
159FLI1_21867929_ChIP-Seq_TH2_Mouse0.66883592
160SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66880276
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.66450747
162SOX2_18555785_Chip-Seq_ESCs_Mouse0.66366009
163TBX20_22328084_ChIP-Seq_HEART_Mouse0.65268040
164TBX20_22080862_ChIP-Seq_HEART_Mouse0.65268040
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.64750071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.60111286
2MP0003195_calcinosis5.32059387
3MP0004043_abnormal_pH_regulation5.21792459
4MP0003183_abnormal_peptide_metabolism4.42247673
5MP0002909_abnormal_adrenal_gland3.38491388
6MP0001944_abnormal_pancreas_morphology3.16804492
7MP0002877_abnormal_melanocyte_morpholog3.15122827
8MP0002138_abnormal_hepatobiliary_system3.06491763
9MP0010386_abnormal_urinary_bladder3.04111995
10MP0005379_endocrine/exocrine_gland_phen2.95588730
11MP0005645_abnormal_hypothalamus_physiol2.92571708
12MP0002693_abnormal_pancreas_physiology2.89905223
13MP0000003_abnormal_adipose_tissue2.87722396
14MP0005220_abnormal_exocrine_pancreas2.70823071
15MP0002837_dystrophic_cardiac_calcinosis2.67884111
16MP0003283_abnormal_digestive_organ2.63344879
17MP0009780_abnormal_chondrocyte_physiolo2.61249060
18MP0004019_abnormal_vitamin_homeostasis2.50921439
19* MP0001765_abnormal_ion_homeostasis2.47140948
20MP0003011_delayed_dark_adaptation2.39623314
21MP0000678_abnormal_parathyroid_gland2.37565464
22* MP0009643_abnormal_urine_homeostasis2.31933106
23* MP0001756_abnormal_urination2.24610704
24MP0005360_urolithiasis2.18073990
25MP0005365_abnormal_bile_salt2.15012555
26MP0002139_abnormal_hepatobiliary_system2.14468209
27MP0008961_abnormal_basal_metabolism2.00824083
28MP0003252_abnormal_bile_duct1.96049246
29* MP0002078_abnormal_glucose_homeostasis1.95748138
30MP0010329_abnormal_lipoprotein_level1.91676100
31* MP0005332_abnormal_amino_acid1.90474819
32MP0004264_abnormal_extraembryonic_tissu1.90183660
33* MP0005636_abnormal_mineral_homeostasis1.88797119
34MP0005084_abnormal_gallbladder_morpholo1.87331123
35MP0002254_reproductive_system_inflammat1.75342306
36MP0002928_abnormal_bile_duct1.72845597
37MP0005058_abnormal_lysosome_morphology1.72802250
38MP0006072_abnormal_retinal_apoptosis1.71361199
39MP0003122_maternal_imprinting1.69953170
40MP0003959_abnormal_lean_body1.65417322
41MP0002638_abnormal_pupillary_reflex1.64008940
42MP0003300_gastrointestinal_ulcer1.61621722
43MP0003172_abnormal_lysosome_physiology1.59811022
44MP0001984_abnormal_olfaction1.57690175
45MP0005257_abnormal_intraocular_pressure1.48011137
46MP0002896_abnormal_bone_mineralization1.47871155
47MP0008877_abnormal_DNA_methylation1.44485117
48MP0005375_adipose_tissue_phenotype1.39781315
49MP0003953_abnormal_hormone_level1.31975500
50MP0003186_abnormal_redox_activity1.27715174
51MP0008872_abnormal_physiological_respon1.25342945
52MP0000538_abnormal_urinary_bladder1.24658731
53MP0002102_abnormal_ear_morphology1.23918187
54MP0003123_paternal_imprinting1.22867850
55* MP0006036_abnormal_mitochondrial_physio1.21148176
56MP0002234_abnormal_pharynx_morphology1.18989236
57* MP0002136_abnormal_kidney_physiology1.14510302
58MP0002876_abnormal_thyroid_physiology1.12471186
59MP0005535_abnormal_body_temperature1.12347774
60MP0004270_analgesia1.11992436
61MP0000230_abnormal_systemic_arterial1.11282735
62MP0009840_abnormal_foam_cell1.09662126
63MP0005408_hypopigmentation1.08540015
64MP0000372_irregular_coat_pigmentation1.07749939
65MP0001986_abnormal_taste_sensitivity1.07210524
66MP0002938_white_spotting1.06555938
67MP0005367_renal/urinary_system_phenotyp1.05834190
68MP0000516_abnormal_urinary_system1.05834190
69MP0005395_other_phenotype1.00224616
70MP0006054_spinal_hemorrhage1.00150464
71MP0002163_abnormal_gland_morphology0.98777879
72MP0002168_other_aberrant_phenotype0.95490435
73MP0009697_abnormal_copulation0.95393207
74MP0005551_abnormal_eye_electrophysiolog0.94621991
75MP0009046_muscle_twitch0.92037866
76MP0002090_abnormal_vision0.90417358
77MP0005670_abnormal_white_adipose0.89629457
78MP0000613_abnormal_salivary_gland0.89522625
79MP0008875_abnormal_xenobiotic_pharmacok0.86789343
80MP0000631_abnormal_neuroendocrine_gland0.86150139
81MP0010678_abnormal_skin_adnexa0.84563254
82MP0005085_abnormal_gallbladder_physiolo0.84439071
83MP0001666_abnormal_nutrient_absorption0.84062495
84MP0005646_abnormal_pituitary_gland0.82862199
85MP0003121_genomic_imprinting0.82337977
86MP0001270_distended_abdomen0.79672607
87* MP0001764_abnormal_homeostasis0.79347796
88MP0003868_abnormal_feces_composition0.79279982
89MP0004885_abnormal_endolymph0.79002296
90MP0003718_maternal_effect0.76227068
91MP0003879_abnormal_hair_cell0.75518113
92MP0006292_abnormal_olfactory_placode0.73195884
93MP0001502_abnormal_circadian_rhythm0.72982474
94MP0004133_heterotaxia0.71987633
95* MP0009642_abnormal_blood_homeostasis0.67422150
96MP0003890_abnormal_embryonic-extraembry0.64127890
97MP0001485_abnormal_pinna_reflex0.63755083
98MP0000427_abnormal_hair_cycle0.62505680
99MP0000462_abnormal_digestive_system0.61635881
100MP0005075_abnormal_melanosome_morpholog0.61466233
101MP0005448_abnormal_energy_balance0.60737795
102MP0005248_abnormal_Harderian_gland0.59500122
103MP0004215_abnormal_myocardial_fiber0.59103824
104MP0003119_abnormal_digestive_system0.59050992
105MP0001661_extended_life_span0.58621809
106* MP0002118_abnormal_lipid_homeostasis0.58535506
107MP0000566_synostosis0.57920543
108MP0001664_abnormal_digestion0.57435195
109MP0003137_abnormal_impulse_conducting0.56807342
110MP0003795_abnormal_bone_structure0.56184555
111* MP0002069_abnormal_eating/drinking_beha0.56002004
112MP0003045_fibrosis0.55218789
113MP0000639_abnormal_adrenal_gland0.54743804
114MP0002751_abnormal_autonomic_nervous0.54541927
115MP0005334_abnormal_fat_pad0.52837379
116MP0005584_abnormal_enzyme/coenzyme_acti0.52697458
117MP0004142_abnormal_muscle_tone0.51725851
118MP0005253_abnormal_eye_physiology0.51639226
119MP0002734_abnormal_mechanical_nocicepti0.51599408
120MP0001299_abnormal_eye_distance/0.50783154
121MP0005319_abnormal_enzyme/_coenzyme0.49221690
122MP0005310_abnormal_salivary_gland0.48472095
123* MP0005452_abnormal_adipose_tissue0.48369687
124MP0002229_neurodegeneration0.47642723
125MP0003787_abnormal_imprinting0.47066059
126MP0010234_abnormal_vibrissa_follicle0.46415143
127MP0009672_abnormal_birth_weight0.46183696
128MP0003866_abnormal_defecation0.45211287
129MP0003633_abnormal_nervous_system0.44835565
130MP0000163_abnormal_cartilage_morphology0.44584713
131MP0001186_pigmentation_phenotype0.42635388
132MP0003638_abnormal_response/metabolism_0.42209977
133MP0000609_abnormal_liver_physiology0.40638678
134MP0001731_abnormal_postnatal_growth0.40216119

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.06298221
2Hyperinsulinemic hypoglycemia (HP:0000825)6.00408820
3Hypoglycemic seizures (HP:0002173)5.58081432
4Hypoglycemic coma (HP:0001325)5.41995179
5Symptomatic seizures (HP:0011145)5.28928442
6Increased circulating renin level (HP:0000848)5.28170945
7Ketoacidosis (HP:0001993)5.18159532
8Abnormality of calcium-phosphate metabolism (HP:0100530)4.82797002
9Gout (HP:0001997)4.66172032
10Hyperactive renin-angiotensin system (HP:0000841)4.50437834
11Abnormality of chloride homeostasis (HP:0011422)4.45593301
12Hyperglycemia (HP:0003074)4.39810851
13Hypokalemic alkalosis (HP:0001949)4.37243466
14Hypomagnesemia (HP:0002917)4.35730347
15Late onset (HP:0003584)4.16122676
16Polyuria (HP:0000103)4.09483273
17Abnormality of renin-angiotensin system (HP:0000847)4.07310525
18Hypokalemia (HP:0002900)4.06937668
19Metabolic alkalosis (HP:0200114)4.02187620
20Pancreatic islet-cell hyperplasia (HP:0004510)3.95592949
21Abnormality of endocrine pancreas physiology (HP:0012093)3.90482856
22Abnormality of the pancreatic islet cells (HP:0006476)3.90482856
23Abnormal urine output (HP:0012590)3.81581449
24Abnormality of magnesium homeostasis (HP:0004921)3.81291768
25Proximal tubulopathy (HP:0000114)3.73764368
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.72793763
27Generalized aminoaciduria (HP:0002909)3.69369939
28Polydipsia (HP:0001959)3.55274390
29Abnormal drinking behavior (HP:0030082)3.55274390
30Abnormality of renal excretion (HP:0011036)3.53072816
31Tetany (HP:0001281)3.50890060
32Abnormality of potassium homeostasis (HP:0011042)3.46936060
33Ketosis (HP:0001946)3.43977854
34Hyperaldosteronism (HP:0000859)3.42494957
35Decreased circulating renin level (HP:0003351)3.27130069
36Large for gestational age (HP:0001520)3.25768246
37Dysostosis multiplex (HP:0000943)3.16318962
38Insulin-resistant diabetes mellitus (HP:0000831)3.14303064
39Retinal atrophy (HP:0001105)3.01158208
40Prolonged partial thromboplastin time (HP:0003645)3.00928399
41Hyperphosphaturia (HP:0003109)3.00428559
42Abnormality of purine metabolism (HP:0004352)2.87982533
43Mucopolysacchariduria (HP:0008155)2.86841815
44Urinary glycosaminoglycan excretion (HP:0003541)2.86841815
45Alkalosis (HP:0001948)2.86585520
46Abnormality of urine glucose concentration (HP:0011016)2.82306035
47Glycosuria (HP:0003076)2.82306035
48Abnormal pancreas size (HP:0012094)2.81288672
49Osteomalacia (HP:0002749)2.80112837
50Hyperparathyroidism (HP:0000843)2.78126683
51Hypophosphatemia (HP:0002148)2.78030706
52Increased purine levels (HP:0004368)2.77866208
53Hyperuricemia (HP:0002149)2.77866208
54Hypothermia (HP:0002045)2.76292805
55Agitation (HP:0000713)2.74780564
56Hypobetalipoproteinemia (HP:0003563)2.65950293
57Renal salt wasting (HP:0000127)2.63714776
58Abnormality of polysaccharide metabolism (HP:0011012)2.62090220
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62090220
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62090220
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60467732
62Hypercalciuria (HP:0002150)2.58594364
63Hyperkalemia (HP:0002153)2.57879177
64Abnormal urine phosphate concentration (HP:0012599)2.54902653
65Vascular calcification (HP:0004934)2.54677143
66Hypotension (HP:0002615)2.49391432
67Hyperphosphatemia (HP:0002905)2.48211760
68Vacuolated lymphocytes (HP:0001922)2.44764989
69Hyperglycinemia (HP:0002154)2.44068715
70Adrenal overactivity (HP:0002717)2.41198261
71Enlarged kidneys (HP:0000105)2.37024817
72Enlarged penis (HP:0000040)2.30781000
73Tubular atrophy (HP:0000092)2.29704814
74Insulin resistance (HP:0000855)2.28172529
75Pheochromocytoma (HP:0002666)2.27429187
76Methylmalonic acidemia (HP:0002912)2.22645955
77Unilateral renal agenesis (HP:0000122)2.19738151
78Dysautonomia (HP:0002459)2.16409970
79Rickets (HP:0002748)2.12841026
80Cardiovascular calcification (HP:0011915)2.11467860
81Prominent metopic ridge (HP:0005487)2.08210563
82Hyperglycinuria (HP:0003108)2.07497515
83Neuroendocrine neoplasm (HP:0100634)2.05694545
84Hyperlipoproteinemia (HP:0010980)2.05578789
85Conjugated hyperbilirubinemia (HP:0002908)2.04340393
86Nephrocalcinosis (HP:0000121)2.02208519
87Renal tubular acidosis (HP:0001947)2.02105602
88Aplasia/Hypoplasia of the fovea (HP:0008060)2.00439275
89Hypoplasia of the fovea (HP:0007750)2.00439275
90Limb hypertonia (HP:0002509)1.98806457
91Abnormality of vitamin B metabolism (HP:0004340)1.98447959
92Abnormality of serine family amino acid metabolism (HP:0010894)1.97611295
93Abnormality of glycine metabolism (HP:0010895)1.97611295
94Xanthomatosis (HP:0000991)1.93997880
95Tachypnea (HP:0002789)1.93536156
96Abnormality of the intrinsic pathway (HP:0010989)1.91908178
97Abnormality of the fovea (HP:0000493)1.91636631
98Steatorrhea (HP:0002570)1.91379945
99Abnormality of sodium homeostasis (HP:0010931)1.91196405
100Intestinal atresia (HP:0011100)1.91089665
101Nephrolithiasis (HP:0000787)1.90754121
102Abnormality of renal resorption (HP:0011038)1.88749991
103Irritability (HP:0000737)1.87632121
104Spontaneous abortion (HP:0005268)1.87505415
105Hyponatremia (HP:0002902)1.84797835
106Abnormality of fatty-acid metabolism (HP:0004359)1.84536312
107Fat malabsorption (HP:0002630)1.83051057
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82853912
109Metaphyseal irregularity (HP:0003025)1.81856983
110Abdominal distention (HP:0003270)1.81567632
111Hepatic necrosis (HP:0002605)1.80717157
112Deep venous thrombosis (HP:0002625)1.80426391
113Widely patent fontanelles and sutures (HP:0004492)1.79982437
114Progressive macrocephaly (HP:0004481)1.79681006
115Orthostatic hypotension (HP:0001278)1.78888094
116Abnormality of nucleobase metabolism (HP:0010932)1.78406509
117Congenital malformation of the right heart (HP:0011723)1.78372643
118Double outlet right ventricle (HP:0001719)1.78372643
119Disproportionate short-trunk short stature (HP:0003521)1.78161829
120Nephrogenic diabetes insipidus (HP:0009806)1.78051121
121Delayed CNS myelination (HP:0002188)1.77540544
122Menstrual irregularities (HP:0000858)1.77538703
123Abnormality of vitamin metabolism (HP:0100508)1.76842352
124Intrahepatic cholestasis (HP:0001406)1.76728473
125Hepatoblastoma (HP:0002884)1.76364552
126Protuberant abdomen (HP:0001538)1.75552498
127EEG with generalized epileptiform discharges (HP:0011198)1.74978146
128Potter facies (HP:0002009)1.74455250
129Facial shape deformation (HP:0011334)1.74455250
130Progressive neurologic deterioration (HP:0002344)1.73985148
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73809618
132Dehydration (HP:0001944)1.69724341
133Abnormality of methionine metabolism (HP:0010901)1.69555802
134Acute encephalopathy (HP:0006846)1.67826851
135Hypolipoproteinemia (HP:0010981)1.67089693
136Complement deficiency (HP:0004431)1.67060291
137Tubulointerstitial nephritis (HP:0001970)1.66482288
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65326721
139Fair hair (HP:0002286)1.65095657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.81258113
2WNK45.81634941
3MAPK155.72016044
4INSRR4.68571191
5PIK3CG3.51005663
6MST42.84958913
7MAP3K22.75619706
8FGFR22.73429667
9FRK2.72613052
10TAOK32.47811751
11PRKD32.34441772
12PASK2.34364543
13MAP4K22.14854964
14CASK2.07040897
15OXSR12.06116124
16HIPK22.06063221
17UHMK12.03924467
18TRPM71.97452187
19GRK11.90561428
20LMTK21.82200358
21WNK11.71135937
22TRIM281.61955066
23PDK21.45207094
24MAP3K121.35499845
25ERN11.30382483
26DYRK1B1.28935489
27MAP3K41.25702394
28PHKG21.25020259
29PHKG11.25020259
30BCKDK1.22845335
31PAK31.18804873
32STK241.12737916
33CSNK1G11.11873729
34TNIK1.11631211
35CAMKK21.07423277
36EPHA31.07055731
37ACVR1B1.06686575
38SCYL21.02865259
39MAP3K10.99669677
40STK30.98766231
41CDC42BPA0.97054624
42IRAK10.96697105
43FLT30.96565784
44PTK20.92697775
45MAP3K30.92632336
46PTK60.92389760
47NTRK10.92306025
48STK390.88921484
49PRKD20.88103343
50SGK4940.86746135
51SGK2230.86746135
52IRAK30.84031976
53EIF2AK30.83891116
54STK38L0.83642168
55MAP2K60.83526939
56NEK10.82768684
57PRKCG0.79759903
58TNK20.79131956
59LIMK10.78611589
60PNCK0.77473756
61FGFR30.74285649
62NUAK10.70183104
63PRKCH0.69639652
64STK160.69565981
65FER0.67076766
66EIF2AK10.65664418
67PLK30.64767980
68DAPK20.64409682
69CSNK1G30.64253976
70BRSK20.64210411
71ZAK0.61076913
72EPHA20.57115307
73FGFR40.56841313
74PRKAA10.56149806
75MAP3K90.55588408
76MAPKAPK30.55220667
77GSK3A0.52470107
78MET0.52292614
79SGK20.51660688
80MKNK20.50583935
81MAP2K20.50150875
82CSNK1G20.50065287
83KSR20.49740574
84PDGFRA0.49633377
85MYLK0.49302832
86AKT30.49080024
87ILK0.48135388
88PRKCI0.47689764
89NTRK30.46778961
90CSNK1A1L0.46627777
91YES10.41784289
92STK110.41699480
93BRAF0.40950615
94SGK10.38006443
95ITK0.37760246
96SGK30.36293153
97JAK20.36193845
98EPHB10.36136809
99TESK10.36038386
100PRKG10.35846686
101ROCK10.34467948
102LATS10.34261397
103DYRK30.32853754
104ERBB40.31988800
105BMPR20.31437228
106PRKCE0.30610154
107MAP3K70.30487303
108PRKG20.30336097
109NLK0.30314686
110FGFR10.29905496
111PINK10.29718936
112BRD40.29618776
113CAMK2D0.28541306
114MTOR0.28354732
115CSNK1A10.27569878
116CSK0.26106691
117RIPK10.25445897
118PDK40.25166145
119PDK30.25166145
120BMPR1B0.25068308
121MAP2K70.23980412
122ERBB30.23616259
123PRKACG0.22539827
124BCR0.22535925
125PLK20.22401919
126PTK2B0.22137061
127ADRBK20.21615650
128ROCK20.21335373
129DAPK10.21301865
130PRKCZ0.20533119
131RET0.20199275
132PLK10.20142057
133CAMKK10.19924058
134PDPK10.18847074
135MST1R0.18801735
136PRKAA20.18684591
137PRKACA0.18456724
138BRSK10.18402255
139NEK60.17454416
140PRKD10.17152618
141TRIB30.16629538
142DYRK1A0.16356160
143RPS6KA20.15543454
144RPS6KA50.15543390
145RPS6KB10.14827881
146PRKCA0.14573523
147CHUK0.14362318
148STK380.13618135
149IRAK20.13502608
150MAP2K10.12756372
151IGF1R0.11571526
152CAMK2B0.10453849
153SIK10.09887354

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.61252200
2Protein export_Homo sapiens_hsa030604.66928046
3Sulfur metabolism_Homo sapiens_hsa009203.18171778
4Insulin secretion_Homo sapiens_hsa049112.81852859
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.80658947
6Caffeine metabolism_Homo sapiens_hsa002322.76126218
7Vitamin B6 metabolism_Homo sapiens_hsa007502.73755200
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.54704087
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33931165
10Retinol metabolism_Homo sapiens_hsa008302.27555836
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16265642
12Butanoate metabolism_Homo sapiens_hsa006501.97558740
13Vibrio cholerae infection_Homo sapiens_hsa051101.95951901
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93522481
15Folate biosynthesis_Homo sapiens_hsa007901.90807964
16Chemical carcinogenesis_Homo sapiens_hsa052041.89838929
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89482995
18Other glycan degradation_Homo sapiens_hsa005111.87310985
19Type I diabetes mellitus_Homo sapiens_hsa049401.86950415
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.81718787
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78717257
22Complement and coagulation cascades_Homo sapiens_hsa046101.75049530
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.73131495
24Arginine biosynthesis_Homo sapiens_hsa002201.69702533
25Collecting duct acid secretion_Homo sapiens_hsa049661.69410946
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66903187
27Lysosome_Homo sapiens_hsa041421.63457689
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.60146407
29Selenocompound metabolism_Homo sapiens_hsa004501.52333922
30Tryptophan metabolism_Homo sapiens_hsa003801.51477125
31Type II diabetes mellitus_Homo sapiens_hsa049301.49801786
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39347343
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27809959
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27309699
35N-Glycan biosynthesis_Homo sapiens_hsa005101.25858582
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22434222
37Peroxisome_Homo sapiens_hsa041461.21366016
38Thyroid hormone synthesis_Homo sapiens_hsa049181.17062989
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17015099
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15907807
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14168685
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12126851
43Circadian rhythm_Homo sapiens_hsa047101.10762453
44Propanoate metabolism_Homo sapiens_hsa006401.09751813
45Cocaine addiction_Homo sapiens_hsa050301.09007878
46Regulation of autophagy_Homo sapiens_hsa041401.08665969
47Fatty acid degradation_Homo sapiens_hsa000711.07468620
48Glucagon signaling pathway_Homo sapiens_hsa049221.07389853
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03711406
50ABC transporters_Homo sapiens_hsa020100.99223641
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97562690
52Protein digestion and absorption_Homo sapiens_hsa049740.94615591
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.93999218
54Starch and sucrose metabolism_Homo sapiens_hsa005000.91075593
55Lysine degradation_Homo sapiens_hsa003100.87953769
56Pyruvate metabolism_Homo sapiens_hsa006200.84432109
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84041823
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82456370
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81793953
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79004777
61Pancreatic secretion_Homo sapiens_hsa049720.77313594
62Amphetamine addiction_Homo sapiens_hsa050310.73130530
63Prion diseases_Homo sapiens_hsa050200.71234163
64Histidine metabolism_Homo sapiens_hsa003400.69831970
65Synaptic vesicle cycle_Homo sapiens_hsa047210.69598591
66Phenylalanine metabolism_Homo sapiens_hsa003600.68747310
67Insulin resistance_Homo sapiens_hsa049310.64171651
68Bile secretion_Homo sapiens_hsa049760.63277947
69PPAR signaling pathway_Homo sapiens_hsa033200.63115424
70Sphingolipid metabolism_Homo sapiens_hsa006000.61179260
71Parkinsons disease_Homo sapiens_hsa050120.60960831
72Arginine and proline metabolism_Homo sapiens_hsa003300.60740807
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60449936
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60405803
75Vitamin digestion and absorption_Homo sapiens_hsa049770.60254619
76Renin-angiotensin system_Homo sapiens_hsa046140.59386729
77Fatty acid metabolism_Homo sapiens_hsa012120.58553885
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57461897
79Fructose and mannose metabolism_Homo sapiens_hsa000510.56284836
80Oxidative phosphorylation_Homo sapiens_hsa001900.55268161
81beta-Alanine metabolism_Homo sapiens_hsa004100.54457123
82Mineral absorption_Homo sapiens_hsa049780.52611092
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51845647
84Steroid biosynthesis_Homo sapiens_hsa001000.49136763
85Galactose metabolism_Homo sapiens_hsa000520.48104017
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47925422
87Linoleic acid metabolism_Homo sapiens_hsa005910.47448179
88Inositol phosphate metabolism_Homo sapiens_hsa005620.47273679
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44346994
90Taste transduction_Homo sapiens_hsa047420.43658951
91GABAergic synapse_Homo sapiens_hsa047270.43616157
92Ether lipid metabolism_Homo sapiens_hsa005650.41410185
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39309232
94Gastric acid secretion_Homo sapiens_hsa049710.38998826
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38900177
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38670108
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.38635532
98One carbon pool by folate_Homo sapiens_hsa006700.38625375
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.38128703
100Dopaminergic synapse_Homo sapiens_hsa047280.36010407
101Metabolic pathways_Homo sapiens_hsa011000.32820292
102Nitrogen metabolism_Homo sapiens_hsa009100.31055851
103Renin secretion_Homo sapiens_hsa049240.30486336
104Arachidonic acid metabolism_Homo sapiens_hsa005900.30343312
105Fatty acid elongation_Homo sapiens_hsa000620.29939304
106Cardiac muscle contraction_Homo sapiens_hsa042600.29701822
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.29437726
108Tyrosine metabolism_Homo sapiens_hsa003500.27831800
109Phototransduction_Homo sapiens_hsa047440.27598696
110Estrogen signaling pathway_Homo sapiens_hsa049150.27301191
111Basal transcription factors_Homo sapiens_hsa030220.27091825
112Insulin signaling pathway_Homo sapiens_hsa049100.26924791
113Serotonergic synapse_Homo sapiens_hsa047260.26718106
114Huntingtons disease_Homo sapiens_hsa050160.26682147
115Glutathione metabolism_Homo sapiens_hsa004800.24503456
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24423132
117Circadian entrainment_Homo sapiens_hsa047130.24321204
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24190715
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22463986
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21607817
121Alzheimers disease_Homo sapiens_hsa050100.21192740
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21133408
123Carbon metabolism_Homo sapiens_hsa012000.20879652
124Prolactin signaling pathway_Homo sapiens_hsa049170.20668483
125Ovarian steroidogenesis_Homo sapiens_hsa049130.19348615
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18902341
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18029410
128Long-term potentiation_Homo sapiens_hsa047200.17807943
129cAMP signaling pathway_Homo sapiens_hsa040240.17718102
130Fat digestion and absorption_Homo sapiens_hsa049750.17709246
131Proteasome_Homo sapiens_hsa030500.16851079
132Dorso-ventral axis formation_Homo sapiens_hsa043200.15050712

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