TMEM30A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.64047122
2synaptic vesicle maturation (GO:0016188)4.43100190
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32611643
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.13309446
5neuronal action potential propagation (GO:0019227)4.10412236
6Golgi transport vesicle coating (GO:0048200)4.09342852
7COPI coating of Golgi vesicle (GO:0048205)4.09342852
8synaptic vesicle exocytosis (GO:0016079)4.06385693
9glutamate secretion (GO:0014047)4.00887708
10locomotory exploration behavior (GO:0035641)3.93004150
11regulation of synaptic vesicle exocytosis (GO:2000300)3.92137112
12skin morphogenesis (GO:0043589)3.80989085
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67726645
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.53623495
15vocalization behavior (GO:0071625)3.52571340
16cellular potassium ion homeostasis (GO:0030007)3.49906882
17* protein localization to endosome (GO:0036010)3.47061244
18neuron cell-cell adhesion (GO:0007158)3.46456852
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.40313030
20regulation of synaptic vesicle transport (GO:1902803)3.38835724
21protein retention in ER lumen (GO:0006621)3.37649493
22endodermal cell differentiation (GO:0035987)3.36872775
23neurotransmitter secretion (GO:0007269)3.36289971
24gamma-aminobutyric acid transport (GO:0015812)3.34752646
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34220135
26hemidesmosome assembly (GO:0031581)3.27702721
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.26288218
28layer formation in cerebral cortex (GO:0021819)3.20226847
29apoptotic cell clearance (GO:0043277)3.20148472
30regulation of neuronal synaptic plasticity (GO:0048168)3.19761805
31regulation of glutamate receptor signaling pathway (GO:1900449)3.17613750
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17314538
33hypotonic response (GO:0006971)3.12758515
34barbed-end actin filament capping (GO:0051016)3.11938901
35exploration behavior (GO:0035640)3.10115823
36protein localization to synapse (GO:0035418)3.07511511
37neuron recognition (GO:0008038)3.06563633
38mating behavior (GO:0007617)3.04924157
39stress fiber assembly (GO:0043149)3.01696083
40glutamate receptor signaling pathway (GO:0007215)2.98415908
41dendritic spine morphogenesis (GO:0060997)2.97640161
42surfactant homeostasis (GO:0043129)2.97292973
43gamma-aminobutyric acid signaling pathway (GO:0007214)2.96679962
44cell-substrate junction assembly (GO:0007044)2.94856218
45activation of protein kinase A activity (GO:0034199)2.93393167
46transmission of nerve impulse (GO:0019226)2.92072266
47cortical actin cytoskeleton organization (GO:0030866)2.91058994
48central nervous system myelination (GO:0022010)2.90981876
49axon ensheathment in central nervous system (GO:0032291)2.90981876
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90570585
51sodium ion export (GO:0071436)2.90337949
52regulation of early endosome to late endosome transport (GO:2000641)2.89727679
53neurotransmitter transport (GO:0006836)2.89436771
54substrate-dependent cell migration (GO:0006929)2.88969079
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87959247
56neuron-neuron synaptic transmission (GO:0007270)2.86910501
57positive regulation of receptor recycling (GO:0001921)2.85209238
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84564422
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.84351157
60synaptic transmission, glutamatergic (GO:0035249)2.82400295
61wound healing, spreading of epidermal cells (GO:0035313)2.82241887
62negative regulation of neurotransmitter transport (GO:0051589)2.79052617
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78619548
64vesicle coating (GO:0006901)2.77796756
65axonal fasciculation (GO:0007413)2.76936748
66proline transport (GO:0015824)2.76669332
67dendrite morphogenesis (GO:0048813)2.75064869
68regulation of synapse structural plasticity (GO:0051823)2.72928238
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69864575
70neuromuscular process controlling posture (GO:0050884)2.69795476
71regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68504192
72potassium ion import (GO:0010107)2.68395540
73vesicle transport along microtubule (GO:0047496)2.68063444
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68046290
75regulation of dendritic spine morphogenesis (GO:0061001)2.66520508
76regulation of neurotransmitter levels (GO:0001505)2.66033259
77presynaptic membrane assembly (GO:0097105)2.65435940
78regulation of vesicle fusion (GO:0031338)2.63778982
79regulation of amyloid precursor protein catabolic process (GO:1902991)2.63427631
80basement membrane organization (GO:0071711)2.61302229
81long-term memory (GO:0007616)2.60018234
82cortical cytoskeleton organization (GO:0030865)2.59367451
83L-amino acid import (GO:0043092)2.58466340
84negative regulation of fatty acid transport (GO:2000192)2.58041498
85regulation of postsynaptic membrane potential (GO:0060078)2.57056574
86positive regulation of membrane potential (GO:0045838)2.56852369
87regulation of synaptic plasticity (GO:0048167)2.56839506
88glycine transport (GO:0015816)2.56598027
89neurotransmitter-gated ion channel clustering (GO:0072578)2.56210032
90long-term synaptic potentiation (GO:0060291)2.56118341
91presynaptic membrane organization (GO:0097090)2.55268230
92positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55267342
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54691942
94neuromuscular process controlling balance (GO:0050885)2.54576756
95positive regulation of osteoblast proliferation (GO:0033690)2.51095284
96regulation of beta-amyloid formation (GO:1902003)2.50916939
97negative regulation of anoikis (GO:2000811)2.50689872
98wound healing, spreading of cells (GO:0044319)2.50689776
99negative regulation of neurotransmitter secretion (GO:0046929)2.49776069
100dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49607872
101protein targeting to Golgi (GO:0000042)2.49480692
102regulation of neurotransmitter secretion (GO:0046928)2.49234252
103membrane raft organization (GO:0031579)2.48713329
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.48541812
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.48376968
106organelle transport along microtubule (GO:0072384)2.48091604
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.48043383
108collagen metabolic process (GO:0032963)2.47102858
109detection of calcium ion (GO:0005513)2.46409752
110suckling behavior (GO:0001967)2.46156925
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44861525
112positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44360591
113potassium ion homeostasis (GO:0055075)2.44112969
114negative regulation of protein localization to plasma membrane (GO:1903077)2.43632500
115collagen fibril organization (GO:0030199)2.43491943
116neuron remodeling (GO:0016322)2.42748957
117regulation of transforming growth factor beta1 production (GO:0032908)2.42745781
118positive regulation of potassium ion transport (GO:0043268)2.42579673
119chondrocyte proliferation (GO:0035988)2.41957583
120nerve growth factor signaling pathway (GO:0038180)2.41179444
121neuronal ion channel clustering (GO:0045161)2.40518820
122cerebellar Purkinje cell differentiation (GO:0021702)2.40416985
123adherens junction assembly (GO:0034333)2.40065643
124mesodermal cell differentiation (GO:0048333)2.39400790
125collagen catabolic process (GO:0030574)2.39226310
126regulation of ARF protein signal transduction (GO:0032012)2.38684487
127cellular copper ion homeostasis (GO:0006878)2.38396323
128regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37517570
129membrane depolarization during action potential (GO:0086010)2.37271010
130regulation of dendritic spine development (GO:0060998)2.37005476
131COPII vesicle coating (GO:0048208)2.36691692
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.36655113
133cellular response to vitamin (GO:0071295)2.36596459
134response to methylmercury (GO:0051597)2.35999942
135adult walking behavior (GO:0007628)2.35714577
136regulation of extracellular matrix disassembly (GO:0010715)2.35455293
137synapse assembly (GO:0007416)2.34026876
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33016103
139multicellular organismal macromolecule metabolic process (GO:0044259)2.32557605
140sequestering of extracellular ligand from receptor (GO:0035581)2.32498848
141regulation of neurotransmitter transport (GO:0051588)2.32450038
142synapse organization (GO:0050808)2.32433366
143cell-substrate adherens junction assembly (GO:0007045)2.32380941
144focal adhesion assembly (GO:0048041)2.32380941
145response to auditory stimulus (GO:0010996)2.32270659
146membrane protein ectodomain proteolysis (GO:0006509)2.32150120
147cellular sodium ion homeostasis (GO:0006883)2.31837836
148membrane depolarization (GO:0051899)2.31698235
149cerebellar granule cell differentiation (GO:0021707)2.31228803
150extracellular matrix disassembly (GO:0022617)2.31179828
151regulation of voltage-gated calcium channel activity (GO:1901385)2.30196163
152establishment of protein localization to Golgi (GO:0072600)2.29292917
153positive regulation of fibroblast migration (GO:0010763)2.28351365
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.28291359
155semaphorin-plexin signaling pathway (GO:0071526)2.27384498
156innervation (GO:0060384)2.27380079
157behavioral response to cocaine (GO:0048148)2.26312035
158positive regulation of macrophage cytokine production (GO:0060907)2.25813105
159response to laminar fluid shear stress (GO:0034616)2.24374902
160clathrin coat assembly (GO:0048268)2.24194115
161positive regulation of axon extension (GO:0045773)2.23795519
162peptidyl-proline hydroxylation (GO:0019511)2.20922808
163multicellular organismal catabolic process (GO:0044243)2.19764989
164cellular response to vitamin D (GO:0071305)2.19497889
165protein hydroxylation (GO:0018126)2.19432630
166epithelial cell-cell adhesion (GO:0090136)2.19085911
167multicellular organismal metabolic process (GO:0044236)2.18087130
168embryonic process involved in female pregnancy (GO:0060136)2.17268448
169vascular endothelial growth factor signaling pathway (GO:0038084)2.16659519
170virion attachment to host cell (GO:0019062)2.16483782
171adhesion of symbiont to host cell (GO:0044650)2.16483782
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.16377975
173regulation of macrophage cytokine production (GO:0010935)2.16310853
174chondrocyte development (GO:0002063)2.16294570
175amino acid import (GO:0043090)2.15546292
176endocytic recycling (GO:0032456)2.13862756
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12678551
178regulation of anoikis (GO:2000209)2.11858616
179localization within membrane (GO:0051668)2.10173986
180import into cell (GO:0098657)2.09136715
181extracellular matrix assembly (GO:0085029)2.08445554
182positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.07792945
183activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.05177135
184positive regulation of cellular amide metabolic process (GO:0034250)2.04742862
185actin filament bundle assembly (GO:0051017)2.03708448
186actin filament bundle organization (GO:0061572)2.03708448
187chemical homeostasis within a tissue (GO:0048875)2.03679190
188protein targeting to plasma membrane (GO:0072661)2.02843164
189regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.02634771
190regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.01673282
191positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.01670609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18072961
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.13617314
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.63830272
4GBX2_23144817_ChIP-Seq_PC3_Human3.07522198
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76402490
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76401012
7CLOCK_20551151_ChIP-Seq_293T_Human2.71122703
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49248794
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36882861
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34432105
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34432105
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33611633
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32774906
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31180233
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30771841
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20835195
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20482970
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18194606
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.11476545
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09141053
21REST_21632747_ChIP-Seq_MESCs_Mouse2.03657187
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.01531754
23DROSHA_22980978_ChIP-Seq_HELA_Human2.01483219
24TAF15_26573619_Chip-Seq_HEK293_Human1.99172666
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99064432
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.96707870
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.96312675
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93623105
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.92512889
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92154390
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89843332
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.89488692
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.89455459
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88182565
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86994857
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85857887
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84734938
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83113811
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.82582935
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.77177484
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.76466537
42AR_21572438_ChIP-Seq_LNCaP_Human1.76399453
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73507528
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.65508775
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60792475
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59248972
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59076457
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59076457
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58623158
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57115084
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54181881
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53283828
53SMAD4_21799915_ChIP-Seq_A2780_Human1.53247942
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52514036
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50607064
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49989395
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47623307
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46482224
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46376380
60KDM2B_26808549_Chip-Seq_K562_Human1.45821218
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45417545
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44931899
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.44449054
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.44375597
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44258766
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43778059
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43576472
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42430165
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41538703
70BRD4_25478319_ChIP-Seq_HGPS_Human1.39224328
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38560815
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38257895
73CJUN_26792858_Chip-Seq_BT549_Human1.36766612
74* P300_19829295_ChIP-Seq_ESCs_Human1.35721874
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35222571
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34285170
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33863603
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33243824
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.32573197
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.32573197
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31057780
82ZNF274_21170338_ChIP-Seq_K562_Hela1.30371212
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29572668
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29560936
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28729286
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28596121
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.27452589
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.26671643
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.25429431
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24852747
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24524604
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23403919
93STAT3_23295773_ChIP-Seq_U87_Human1.23334118
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22426151
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21507041
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21377119
97SOX2_20726797_ChIP-Seq_SW620_Human1.21085748
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20781901
99* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19643871
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19499773
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19383897
102AR_25329375_ChIP-Seq_VCAP_Human1.17745243
103* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17195791
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15967342
105IRF8_27001747_Chip-Seq_BMDM_Mouse1.14968659
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.14433684
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.14408639
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13993374
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13798502
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12975767
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12683841
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11925953
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11910886
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11409098
115NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11409098
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11013463
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09849763
118AHR_22903824_ChIP-Seq_MCF-7_Human1.08980542
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.08527470
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08370174
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07944496
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07444294
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.07390049
124IGF1R_20145208_ChIP-Seq_DFB_Human1.06306110
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04165830
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04006561
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.03801626
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03749334
129VDR_22108803_ChIP-Seq_LS180_Human1.03574716
130AR_19668381_ChIP-Seq_PC3_Human1.01778831
131BCAT_22108803_ChIP-Seq_LS180_Human1.01641452
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01047113
133TCF4_23295773_ChIP-Seq_U87_Human0.99780487
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99720172
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99600841
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99446649
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99335713
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.98094078
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97936137
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97880036
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97751909
142RUNX2_22187159_ChIP-Seq_PCA_Human0.97093711
143ER_23166858_ChIP-Seq_MCF-7_Human0.96648803
144TCF7_22412390_ChIP-Seq_EML_Mouse0.96225565
145* TP53_18474530_ChIP-ChIP_U2OS_Human0.96103401
146* TP53_16413492_ChIP-PET_HCT116_Human0.95768337
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95581549
148RACK7_27058665_Chip-Seq_MCF-7_Human0.95396990
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95352834
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.95340716
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.94114505
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.93862603
153* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93454258
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.93083153
155SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91975767
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91483223
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.90940460
158UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90849092
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90807045
160* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90782387
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88924536
162RXR_22108803_ChIP-Seq_LS180_Human0.88684051
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88675334
164HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88222173
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87748873
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87365500
167YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87052783
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86429327
169TRIM28_21343339_ChIP-Seq_HEK293_Human0.84400593
170SMAD3_21741376_ChIP-Seq_HESCs_Human0.84086517
171TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83497911
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.83333698
173* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83273451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.23951979
2MP0004859_abnormal_synaptic_plasticity5.03235302
3MP0003880_abnormal_central_pattern4.19774362
4MP0003705_abnormal_hypodermis_morpholog4.16764621
5MP0004270_analgesia3.58093929
6MP0003635_abnormal_synaptic_transmissio3.48455221
7MP0004272_abnormal_basement_membrane3.28141178
8MP0003566_abnormal_cell_adhesion3.22035004
9MP0002877_abnormal_melanocyte_morpholog3.14305415
10MP0001958_emphysema3.08806637
11MP0009745_abnormal_behavioral_response2.86818950
12MP0002064_seizures2.84564277
13MP0002063_abnormal_learning/memory/cond2.69648779
14MP0003329_amyloid_beta_deposits2.66320897
15MP0009046_muscle_twitch2.65910796
16MP0003091_abnormal_cell_migration2.65539711
17MP0003300_gastrointestinal_ulcer2.65038110
18MP0003279_aneurysm2.62086228
19MP0005275_abnormal_skin_tensile2.58161529
20MP0001968_abnormal_touch/_nociception2.55134671
21MP0002272_abnormal_nervous_system2.44739200
22MP0003191_abnormal_cellular_cholesterol2.40819619
23MP0009780_abnormal_chondrocyte_physiolo2.40408199
24MP0010352_gastrointestinal_tract_polyps2.35493386
25MP0005257_abnormal_intraocular_pressure2.35349173
26MP0002734_abnormal_mechanical_nocicepti2.33869231
27MP0002572_abnormal_emotion/affect_behav2.29937670
28MP0001486_abnormal_startle_reflex2.25852930
29MP0010368_abnormal_lymphatic_system2.13408656
30MP0005058_abnormal_lysosome_morphology2.12881571
31MP0002909_abnormal_adrenal_gland2.07137931
32MP0001440_abnormal_grooming_behavior2.04269265
33MP0001501_abnormal_sleep_pattern2.00196779
34MP0002735_abnormal_chemical_nociception1.99992808
35MP0002733_abnormal_thermal_nociception1.95845942
36MP0002822_catalepsy1.93203645
37MP0002736_abnormal_nociception_after1.91038368
38MP0005423_abnormal_somatic_nervous1.90916019
39MP0006054_spinal_hemorrhage1.89420774
40MP0000920_abnormal_myelination1.86558739
41MP0001970_abnormal_pain_threshold1.80571310
42MP0002067_abnormal_sensory_capabilities1.77649898
43MP0002896_abnormal_bone_mineralization1.73786490
44MP0000013_abnormal_adipose_tissue1.69762190
45MP0005409_darkened_coat_color1.65864030
46MP0003690_abnormal_glial_cell1.65777080
47MP0004885_abnormal_endolymph1.63607367
48MP0005023_abnormal_wound_healing1.60970349
49MP0000604_amyloidosis1.59801814
50MP0004858_abnormal_nervous_system1.59056222
51MP0008569_lethality_at_weaning1.56875515
52MP0005386_behavior/neurological_phenoty1.56786652
53MP0004924_abnormal_behavior1.56786652
54MP0003633_abnormal_nervous_system1.54946856
55MP0006276_abnormal_autonomic_nervous1.54936872
56MP0004043_abnormal_pH_regulation1.53246691
57MP0003941_abnormal_skin_development1.48598497
58MP0000767_abnormal_smooth_muscle1.47335739
59MP0003828_pulmonary_edema1.46804553
60MP0002060_abnormal_skin_morphology1.46669853
61MP0000778_abnormal_nervous_system1.44349007
62MP0001542_abnormal_bone_strength1.44199027
63MP0008260_abnormal_autophagy1.41495130
64MP0002184_abnormal_innervation1.40981725
65MP0000955_abnormal_spinal_cord1.40030799
66MP0009840_abnormal_foam_cell1.39934760
67MP0001348_abnormal_lacrimal_gland1.39924743
68MP0005503_abnormal_tendon_morphology1.36574417
69MP0003195_calcinosis1.36431739
70MP0002139_abnormal_hepatobiliary_system1.35813854
71MP0002557_abnormal_social/conspecific_i1.34097575
72MP0002066_abnormal_motor_capabilities/c1.30879533
73MP0001849_ear_inflammation1.30777266
74MP0004811_abnormal_neuron_physiology1.30525451
75MP0001915_intracranial_hemorrhage1.30449462
76MP0002837_dystrophic_cardiac_calcinosis1.28814170
77MP0002998_abnormal_bone_remodeling1.26947613
78MP0003631_nervous_system_phenotype1.25771777
79MP0003634_abnormal_glial_cell1.25767786
80MP0003448_altered_tumor_morphology1.23901673
81MP0005646_abnormal_pituitary_gland1.23473719
82MP0004142_abnormal_muscle_tone1.23306941
83MP0003303_peritoneal_inflammation1.22519870
84MP0002229_neurodegeneration1.20397593
85MP0005164_abnormal_response_to1.20033150
86MP0001905_abnormal_dopamine_level1.20007679
87MP0002882_abnormal_neuron_morphology1.19762813
88MP0002295_abnormal_pulmonary_circulatio1.19304483
89MP0004782_abnormal_surfactant_physiolog1.19123143
90MP0005535_abnormal_body_temperature1.18557409
91MP0005165_increased_susceptibility_to1.17101434
92MP0001984_abnormal_olfaction1.16716548
93MP0010386_abnormal_urinary_bladder1.16188935
94MP0000858_altered_metastatic_potential1.15968776
95MP0002133_abnormal_respiratory_system1.15727919
96MP0005388_respiratory_system_phenotype1.15727919
97MP0008004_abnormal_stomach_pH1.13854786
98MP0003453_abnormal_keratinocyte_physiol1.13767661
99MP0001529_abnormal_vocalization1.12131918
100MP0001502_abnormal_circadian_rhythm1.07992267
101MP0004742_abnormal_vestibular_system1.07803614
102MP0003879_abnormal_hair_cell1.07662733
103MP0004145_abnormal_muscle_electrophysio1.07167815
104MP0005645_abnormal_hypothalamus_physiol1.06255462
105MP0006082_CNS_inflammation1.02722721
106MP0001879_abnormal_lymphatic_vessel1.00614653
107MP0001177_atelectasis0.99811843
108MP0010234_abnormal_vibrissa_follicle0.98479790
109MP0008875_abnormal_xenobiotic_pharmacok0.98412375
110MP0005085_abnormal_gallbladder_physiolo0.98318988
111MP0005360_urolithiasis0.97369428
112MP0003632_abnormal_nervous_system0.97165239
113MP0005595_abnormal_vascular_smooth0.96449223
114MP0001533_abnormal_skeleton_physiology0.96382345
115MP0005508_abnormal_skeleton_morphology0.96331981
116MP0000534_abnormal_ureter_morphology0.95904878
117MP0005076_abnormal_cell_differentiation0.95388859
118MP0003075_altered_response_to0.95244960
119MP0002090_abnormal_vision0.94920360
120MP0003283_abnormal_digestive_organ0.94819808
121MP0003950_abnormal_plasma_membrane0.94763043
122MP0005551_abnormal_eye_electrophysiolog0.93982638
123MP0000733_abnormal_muscle_development0.93981118
124MP0008874_decreased_physiological_sensi0.93143863
125MP0000343_altered_response_to0.90612261
126MP0004947_skin_inflammation0.89701575
127MP0001299_abnormal_eye_distance/0.87947606
128MP0005621_abnormal_cell_physiology0.87116756
129MP0005166_decreased_susceptibility_to0.86956098
130MP0001851_eye_inflammation0.85359611
131MP0009384_cardiac_valve_regurgitation0.85346688
132MP0001243_abnormal_dermal_layer0.85221420
133MP0002069_abnormal_eating/drinking_beha0.85034549
134MP0001765_abnormal_ion_homeostasis0.84589637
135MP0003172_abnormal_lysosome_physiology0.83614379
136MP0003183_abnormal_peptide_metabolism0.80516502
137MP0005167_abnormal_blood-brain_barrier0.78456940
138MP0005390_skeleton_phenotype0.78177321
139MP0003436_decreased_susceptibility_to0.77294112
140MP0002152_abnormal_brain_morphology0.77293402
141MP0004883_abnormal_blood_vessel0.77279600
142MP0000747_muscle_weakness0.77111006
143MP0003868_abnormal_feces_composition0.77017290
144MP0005083_abnormal_biliary_tract0.76498749
145MP0004085_abnormal_heartbeat0.76043069
146MP0000465_gastrointestinal_hemorrhage0.75119972
147MP0003724_increased_susceptibility_to0.74949606
148MP0001664_abnormal_digestion0.74228563
149MP0004130_abnormal_muscle_cell0.73503466
150MP0005623_abnormal_meninges_morphology0.73011864
151MP0003045_fibrosis0.72090431
152MP0001963_abnormal_hearing_physiology0.72004648
153MP0001614_abnormal_blood_vessel0.71709818
154MP0000569_abnormal_digit_pigmentation0.71281918
155MP0002118_abnormal_lipid_homeostasis0.70574427
156MP0008872_abnormal_physiological_respon0.69973827
157MP0004036_abnormal_muscle_relaxation0.69689483
158MP0008961_abnormal_basal_metabolism0.66810343
159MP0005451_abnormal_body_composition0.66315405
160MP0005365_abnormal_bile_salt0.66292475
161MP0001485_abnormal_pinna_reflex0.66098677
162MP0003795_abnormal_bone_structure0.66021139
163MP0000751_myopathy0.65164473
164MP0005332_abnormal_amino_acid0.64905937
165MP0010329_abnormal_lipoprotein_level0.64752491
166MP0002078_abnormal_glucose_homeostasis0.64478947
167MP0000003_abnormal_adipose_tissue0.63984848
168MP0002876_abnormal_thyroid_physiology0.63610588
169MP0000230_abnormal_systemic_arterial0.63290880
170MP0004510_myositis0.62681681
171MP0000762_abnormal_tongue_morphology0.62656854
172MP0000428_abnormal_craniofacial_morphol0.61751562
173MP0001175_abnormal_lung_morphology0.60234221
174MP0000249_abnormal_blood_vessel0.60153548
175MP0002128_abnormal_blood_circulation0.58778379
176MP0005197_abnormal_uvea_morphology0.57281169

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.73475713
2Premature rupture of membranes (HP:0001788)5.14508465
3Myokymia (HP:0002411)4.84818820
4Protrusio acetabuli (HP:0003179)4.71189471
5Neurofibrillary tangles (HP:0002185)4.50575351
6Focal seizures (HP:0007359)4.37509437
7Visual hallucinations (HP:0002367)4.16713997
8Arterial tortuosity (HP:0005116)4.03744938
9Atonic seizures (HP:0010819)4.02337021
10Cerebral inclusion bodies (HP:0100314)4.02121498
11Vascular tortuosity (HP:0004948)3.98234267
12Supranuclear gaze palsy (HP:0000605)3.93391671
13Action tremor (HP:0002345)3.64663054
14Absence seizures (HP:0002121)3.57222007
15Aortic dissection (HP:0002647)3.54320871
16Atrophic scars (HP:0001075)3.45266475
17Epileptic encephalopathy (HP:0200134)3.43133339
18Termporal pattern (HP:0011008)3.37886004
19Insidious onset (HP:0003587)3.37886004
20Generalized tonic-clonic seizures (HP:0002069)3.30239388
21Dialeptic seizures (HP:0011146)3.23942123
22Abnormality of the corticospinal tract (HP:0002492)3.06584507
23Ankle clonus (HP:0011448)3.06302906
24Dysmetria (HP:0001310)3.04239258
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99953713
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.99953713
27Intention tremor (HP:0002080)2.97837933
28Pheochromocytoma (HP:0002666)2.97719084
29Aortic aneurysm (HP:0004942)2.97104437
30Progressive cerebellar ataxia (HP:0002073)2.97019442
31Cerebral aneurysm (HP:0004944)2.93541787
32Vertebral compression fractures (HP:0002953)2.87960366
33Scanning speech (HP:0002168)2.86259902
34Spastic gait (HP:0002064)2.84548340
35Osteolytic defects of the hand bones (HP:0009699)2.77632316
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.77632316
37Papilledema (HP:0001085)2.77006967
38Truncal ataxia (HP:0002078)2.73747649
39Wormian bones (HP:0002645)2.73135895
40Febrile seizures (HP:0002373)2.72062825
41Hyperventilation (HP:0002883)2.67965699
42Anxiety (HP:0000739)2.67344377
43Dysdiadochokinesis (HP:0002075)2.66768462
44Impaired vibration sensation in the lower limbs (HP:0002166)2.62033795
45Dilatation of the ascending aorta (HP:0005111)2.61484143
46Depression (HP:0000716)2.61477522
47Ankle contracture (HP:0006466)2.58049215
48Bladder diverticulum (HP:0000015)2.57457166
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55491514
50Urinary urgency (HP:0000012)2.54756233
51Neuroendocrine neoplasm (HP:0100634)2.54434786
52Mitral stenosis (HP:0001718)2.53054094
53Fragile skin (HP:0001030)2.52712026
54Postural instability (HP:0002172)2.48231285
55Abnormality of liposaccharide metabolism (HP:0010968)2.48066742
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.48066742
57Abnormality of glycolipid metabolism (HP:0010969)2.48066742
58Poor eye contact (HP:0000817)2.47067048
59Agitation (HP:0000713)2.46194104
60Abnormal eating behavior (HP:0100738)2.44690677
61Impaired social interactions (HP:0000735)2.40489822
62Abnormal social behavior (HP:0012433)2.40489822
63Mitral valve prolapse (HP:0001634)2.39507504
64Broad-based gait (HP:0002136)2.37985269
65Overgrowth (HP:0001548)2.36853595
66Increased circulating renin level (HP:0000848)2.36817009
67Urinary bladder sphincter dysfunction (HP:0002839)2.34412861
68Cervical subluxation (HP:0003308)2.34388752
69Peritonitis (HP:0002586)2.33801116
70Drooling (HP:0002307)2.31679058
71Excessive salivation (HP:0003781)2.31679058
72Mutism (HP:0002300)2.30716183
73Progressive inability to walk (HP:0002505)2.29952407
74Megalencephaly (HP:0001355)2.28337205
75Lower limb muscle weakness (HP:0007340)2.28256501
76Cerebral hemorrhage (HP:0001342)2.27400845
77Spinal rigidity (HP:0003306)2.26359003
78Gaze-evoked nystagmus (HP:0000640)2.25329582
79Epileptiform EEG discharges (HP:0011182)2.21835123
80Ankyloglossia (HP:0010296)2.20801365
81Spondylolisthesis (HP:0003302)2.20262905
82Neuronal loss in central nervous system (HP:0002529)2.19718250
83Torticollis (HP:0000473)2.19435990
84Follicular hyperkeratosis (HP:0007502)2.19220870
85EEG with generalized epileptiform discharges (HP:0011198)2.18922120
86Hemiparesis (HP:0001269)2.18601810
87Dysostosis multiplex (HP:0000943)2.17625321
88Blue sclerae (HP:0000592)2.16082840
89Soft skin (HP:0000977)2.15865964
90Urinary glycosaminoglycan excretion (HP:0003541)2.15490054
91Mucopolysacchariduria (HP:0008155)2.15490054
92Blue irides (HP:0000635)2.15483426
93Generalized myoclonic seizures (HP:0002123)2.14232231
94Interstitial pulmonary disease (HP:0006530)2.13666868
95Genu recurvatum (HP:0002816)2.13374837
96Aneurysm (HP:0002617)2.13347240
97Hemiplegia (HP:0002301)2.11598216
98Status epilepticus (HP:0002133)2.11457087
99Abnormality of dentin (HP:0010299)2.11010610
100Abnormality of oral frenula (HP:0000190)2.09782756
101Hyperextensible skin (HP:0000974)2.09453967
102Onion bulb formation (HP:0003383)2.09110154
103Amblyopia (HP:0000646)2.08936794
104Abnormality of binocular vision (HP:0011514)2.08633146
105Diplopia (HP:0000651)2.08633146
106Hypsarrhythmia (HP:0002521)2.08129346
107Clonus (HP:0002169)2.07998170
108Increased variability in muscle fiber diameter (HP:0003557)2.07497667
109Retinal dysplasia (HP:0007973)2.07216238
110Postural tremor (HP:0002174)2.04369934
111Short nail (HP:0001799)2.04125224
112Shallow orbits (HP:0000586)2.02415986
113Mitral regurgitation (HP:0001653)2.01302492
114Peripheral hypomyelination (HP:0007182)2.00419915
115Distal upper limb amyotrophy (HP:0007149)1.99925235
116Upper limb amyotrophy (HP:0009129)1.99925235
117Rapidly progressive (HP:0003678)1.99601096
118Absent frontal sinuses (HP:0002688)1.99494076
119Vertebral arch anomaly (HP:0008438)1.98792252
120Focal dystonia (HP:0004373)1.98079325
121Neonatal short-limb short stature (HP:0008921)1.94760619
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94639716
123Bradykinesia (HP:0002067)1.94114493
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93526387
125Abnormality of polysaccharide metabolism (HP:0011012)1.93526387
126Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93526387
127Psychosis (HP:0000709)1.91796077
128Hammertoe (HP:0001765)1.91671449
129Spinal cord lesions (HP:0100561)1.91066363
130Syringomyelia (HP:0003396)1.91066363
131Craniofacial dystonia (HP:0012179)1.87399359
132Hypokalemic alkalosis (HP:0001949)1.86218114
133Rigidity (HP:0002063)1.86202872
134Myocardial infarction (HP:0001658)1.85166775
135Limb dystonia (HP:0002451)1.83442074
136Metabolic alkalosis (HP:0200114)1.83403349
137Tetraparesis (HP:0002273)1.81186639
138Resting tremor (HP:0002322)1.80743159
139Akinesia (HP:0002304)1.80149465
140Gait ataxia (HP:0002066)1.79905560
141Joint laxity (HP:0001388)1.79803263
142Insomnia (HP:0100785)1.79750941
143Apathy (HP:0000741)1.78011905
144Thickened helices (HP:0000391)1.77609315
145Hand muscle atrophy (HP:0009130)1.77507035
146Abnormality of skeletal muscle fiber size (HP:0012084)1.77167843
147Amyloidosis (HP:0011034)1.75985179
148Impaired vibratory sensation (HP:0002495)1.74763810
149Lower limb amyotrophy (HP:0007210)1.74358347
150Flat acetabular roof (HP:0003180)1.74116462
151Morphological abnormality of the pyramidal tract (HP:0002062)1.74033107
152Abnormality of calcium-phosphate metabolism (HP:0100530)1.73948197
153Stereotypic behavior (HP:0000733)1.72261020
154Long toe (HP:0010511)1.71856216
155Achilles tendon contracture (HP:0001771)1.71279856
156Abnormality of saccadic eye movements (HP:0000570)1.71091773
157Broad metatarsal (HP:0001783)1.70527221
158Mildly elevated creatine phosphokinase (HP:0008180)1.70247661
159Deep venous thrombosis (HP:0002625)1.70014797
160Type II lissencephaly (HP:0007260)1.70001072
161Ketoacidosis (HP:0001993)1.69779057
162Hyperlipoproteinemia (HP:0010980)1.69312803
163Clumsiness (HP:0002312)1.68716612
164Hyperacusis (HP:0010780)1.68611075
165Broad face (HP:0000283)1.68141863
166Bowel diverticulosis (HP:0005222)1.68050828
167Ulnar bowing (HP:0003031)1.67827792
168Mild short stature (HP:0003502)1.67702801
169Diminished motivation (HP:0000745)1.67402892
170Subacute progressive viral hepatitis (HP:0006572)1.66055030
171Absent speech (HP:0001344)1.65963045
172Spastic tetraparesis (HP:0001285)1.65243416
173Abnormality of the acetabulum (HP:0003170)1.64803831
174Obstructive sleep apnea (HP:0002870)1.64588506
175Buphthalmos (HP:0000557)1.64555025
176Abnormality of salivation (HP:0100755)1.64481340
177Distal lower limb amyotrophy (HP:0008944)1.64034671
178Hyperparathyroidism (HP:0000843)1.62155638
179Asymmetry of the thorax (HP:0001555)1.61586902
180Osteopenia (HP:0000938)1.61490955
181Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61353579
182Type 1 muscle fiber predominance (HP:0003803)1.60131396
183Disproportionate tall stature (HP:0001519)1.59990754
184Loss of speech (HP:0002371)1.59956536
185Striae distensae (HP:0001065)1.59628896
186Cardiovascular calcification (HP:0011915)1.58135508
187Relative macrocephaly (HP:0004482)1.57917033
188Camptodactyly of toe (HP:0001836)1.56951918
189Increased connective tissue (HP:0009025)1.55891890
190Thin bony cortex (HP:0002753)1.55776594
191Slender build (HP:0001533)1.55672816
192Arnold-Chiari malformation (HP:0002308)1.55467462
193Abnormality of the Achilles tendon (HP:0005109)1.55017130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.81918996
2EPHA43.27959588
3PDGFRA3.15532255
4MAP3K93.13891789
5NTRK12.77676750
6LATS22.72049107
7KSR22.43609840
8MAP3K42.33489625
9STK392.32885057
10MARK12.20806298
11MINK12.19913404
12PAK62.15287222
13OXSR12.03524665
14NEK92.00900052
15DAPK21.98552081
16MAP3K21.89499706
17TTN1.87801847
18TGFBR21.84013570
19TRIB31.80203618
20RIPK41.79335167
21ERN11.78962193
22MAP2K41.75516697
23WNK41.65432621
24MAP2K71.64797696
25TIE11.62727308
26PRKD31.57433570
27PNCK1.56854849
28NTRK21.53435142
29DDR21.52808022
30JAK11.47756084
31CAMKK11.47026552
32ARAF1.45603480
33PAK41.43889224
34CDK51.43464874
35TESK11.42852242
36MAP3K131.42380272
37CAMKK21.41139542
38FGFR41.38963206
39MAP3K61.37996779
40MOS1.35435355
41MYLK1.35153042
42FGFR21.33400921
43PDGFRB1.31488030
44CASK1.31407223
45LATS11.29936298
46WNK11.29341588
47KSR11.29065322
48PAK31.28687583
49UHMK11.26391890
50MST1R1.26167199
51MAP3K121.22451018
52GRK51.21140491
53RET1.20511681
54MAP3K141.15951737
55PAK21.11917706
56FES1.11585589
57ICK1.11570644
58TNIK1.10321554
59INSRR1.07931074
60CDK191.07872023
61CAMK2B1.06975040
62PRKCH1.05537440
63CAMK2A1.04757385
64EPHA21.03829251
65SIK11.03761585
66TRPM71.02229153
67PLK21.01736784
68CSNK1G21.00231589
69SGK2231.00125586
70SGK4941.00125586
71EPHB20.99195590
72TYRO30.98648907
73MAP3K10.98572844
74PHKG20.96156500
75PHKG10.96156500
76CDK60.95076407
77RPS6KA20.92257420
78PDPK10.91289190
79PRKCG0.91064703
80CAMK1G0.90244343
81WNK30.89610557
82FGFR30.88903317
83EEF2K0.86360157
84EPHB10.85843742
85FER0.84553946
86TYK20.84383173
87PTK2B0.82058894
88IRAK30.81851219
89ERBB40.79906279
90CDC42BPA0.78438542
91CAMK2D0.78156640
92STK110.77725630
93PKN20.77119266
94ZAP700.76993475
95CDK140.76747696
96MAP3K30.76058334
97PDK10.74980416
98PKN10.74734748
99PRKCE0.74642846
100CAMK2G0.74394832
101SCYL20.73197660
102MAPK130.73194485
103STK380.72260934
104MAPKAPK50.72194127
105LMTK20.70728119
106MAP2K30.70668416
107YES10.70433337
108BCR0.69624656
109FGR0.69579890
110FRK0.68363697
111LIMK10.66547662
112CDK150.65857885
113CDK180.65056829
114RAF10.64603951
115SGK10.61558554
116DYRK1B0.61318831
117SIK20.60271966
118MARK20.59653567
119BMPR20.59280527
120FYN0.58422861
121BRAF0.57729859
122ROCK20.57706315
123MAP2K10.57289124
124SGK20.56669386
125DAPK10.56371712
126PRKG20.56361876
127CSK0.55863370
128NEK60.55318416
129CAMK10.55291694
130ERBB30.55250738
131PTK60.53604616
132CDK11A0.52628309
133JAK20.52600597
134AKT30.52394260
135MET0.52310635
136PRKD20.50913215
137MAPK70.50882564
138CSNK1G30.50386225
139PRPF4B0.48102415
140CDK120.47729526
141PRKCQ0.47613044
142PINK10.47495296
143PTK20.47482719
144PRKCZ0.47411039
145MTOR0.47410559
146SRC0.46633824
147HIPK20.44366030
148DYRK1A0.44229700
149DMPK0.44103651
150MAPK150.44022411
151PRKD10.43923579
152SGK30.42217631
153CSNK1A1L0.42032982
154RIPK10.39701108

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.56629140
2Synaptic vesicle cycle_Homo sapiens_hsa047212.43743384
3GABAergic synapse_Homo sapiens_hsa047272.26905236
4Nitrogen metabolism_Homo sapiens_hsa009102.25917304
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09104704
6Long-term potentiation_Homo sapiens_hsa047202.01658117
7Circadian entrainment_Homo sapiens_hsa047131.99295350
8Glutamatergic synapse_Homo sapiens_hsa047241.97644183
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93742395
10ECM-receptor interaction_Homo sapiens_hsa045121.91835010
11Morphine addiction_Homo sapiens_hsa050321.88724777
12Amphetamine addiction_Homo sapiens_hsa050311.86464807
13Olfactory transduction_Homo sapiens_hsa047401.82926286
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82172703
15Insulin secretion_Homo sapiens_hsa049111.81149777
16Focal adhesion_Homo sapiens_hsa045101.77094788
17Salivary secretion_Homo sapiens_hsa049701.74979657
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74092179
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70388847
20Other glycan degradation_Homo sapiens_hsa005111.70264041
21Dopaminergic synapse_Homo sapiens_hsa047281.70143080
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.67332788
23Gastric acid secretion_Homo sapiens_hsa049711.60514130
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57494869
25Renin secretion_Homo sapiens_hsa049241.53663335
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53659566
27Taste transduction_Homo sapiens_hsa047421.49372557
28Amoebiasis_Homo sapiens_hsa051461.49331069
29Cholinergic synapse_Homo sapiens_hsa047251.46298093
30Proteoglycans in cancer_Homo sapiens_hsa052051.45726790
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43965381
32Long-term depression_Homo sapiens_hsa047301.41494628
33Cocaine addiction_Homo sapiens_hsa050301.40835314
34Serotonergic synapse_Homo sapiens_hsa047261.40553245
35Collecting duct acid secretion_Homo sapiens_hsa049661.39557341
36Chronic myeloid leukemia_Homo sapiens_hsa052201.35237286
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35110306
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30669346
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25484218
40Adherens junction_Homo sapiens_hsa045201.25021711
41Butanoate metabolism_Homo sapiens_hsa006501.22897366
42Oxytocin signaling pathway_Homo sapiens_hsa049211.20209300
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.17370257
44Bladder cancer_Homo sapiens_hsa052191.15661517
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.15342279
46Pancreatic cancer_Homo sapiens_hsa052121.14443934
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11432807
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09838875
49Vibrio cholerae infection_Homo sapiens_hsa051101.09590256
50Type II diabetes mellitus_Homo sapiens_hsa049301.09530867
51Endometrial cancer_Homo sapiens_hsa052131.09428496
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05963551
53Calcium signaling pathway_Homo sapiens_hsa040201.04595844
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.03850196
55Bile secretion_Homo sapiens_hsa049761.03349569
56GnRH signaling pathway_Homo sapiens_hsa049121.02280029
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01861769
58Salmonella infection_Homo sapiens_hsa051321.01178745
59Phagosome_Homo sapiens_hsa041451.00850771
60Small cell lung cancer_Homo sapiens_hsa052221.00676043
61Gap junction_Homo sapiens_hsa045400.99262714
62Dorso-ventral axis formation_Homo sapiens_hsa043200.99134348
63Non-small cell lung cancer_Homo sapiens_hsa052230.97766474
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97228610
65Sulfur metabolism_Homo sapiens_hsa009200.96757280
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96679702
67Shigellosis_Homo sapiens_hsa051310.96531744
68cAMP signaling pathway_Homo sapiens_hsa040240.96024878
69Pancreatic secretion_Homo sapiens_hsa049720.94490916
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94390296
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93925510
72Estrogen signaling pathway_Homo sapiens_hsa049150.93396921
73Axon guidance_Homo sapiens_hsa043600.93338893
74Thyroid cancer_Homo sapiens_hsa052160.92506034
75Protein digestion and absorption_Homo sapiens_hsa049740.92481205
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92446410
77Thyroid hormone synthesis_Homo sapiens_hsa049180.89315040
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87688522
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.87531030
80Osteoclast differentiation_Homo sapiens_hsa043800.86939485
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86881324
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86725224
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.86327513
84Arginine biosynthesis_Homo sapiens_hsa002200.84721110
85Toxoplasmosis_Homo sapiens_hsa051450.84212749
86Pertussis_Homo sapiens_hsa051330.82917736
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82915379
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82696055
89Prolactin signaling pathway_Homo sapiens_hsa049170.82535811
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82354183
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81492146
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80302234
93Malaria_Homo sapiens_hsa051440.79551897
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77587771
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.77150993
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75387560
97Fatty acid elongation_Homo sapiens_hsa000620.75132503
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74389293
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74206356
100Glioma_Homo sapiens_hsa052140.74147869
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73976447
102ErbB signaling pathway_Homo sapiens_hsa040120.73817410
103Prion diseases_Homo sapiens_hsa050200.73071966
104Complement and coagulation cascades_Homo sapiens_hsa046100.72427895
105MicroRNAs in cancer_Homo sapiens_hsa052060.72240588
106Platelet activation_Homo sapiens_hsa046110.71449914
107Acute myeloid leukemia_Homo sapiens_hsa052210.71058082
108TNF signaling pathway_Homo sapiens_hsa046680.70212887
109mTOR signaling pathway_Homo sapiens_hsa041500.69790483
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69600700
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69277863
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.68999645
113Melanogenesis_Homo sapiens_hsa049160.68812350
114Hepatitis C_Homo sapiens_hsa051600.67910188
115Insulin signaling pathway_Homo sapiens_hsa049100.67098710
116Tuberculosis_Homo sapiens_hsa051520.66557266
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65816597
118Prostate cancer_Homo sapiens_hsa052150.64284344
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62084104
120Leishmaniasis_Homo sapiens_hsa051400.61505838
121Cardiac muscle contraction_Homo sapiens_hsa042600.61227362
122HIF-1 signaling pathway_Homo sapiens_hsa040660.60918480
123Hepatitis B_Homo sapiens_hsa051610.60625000
124Pathways in cancer_Homo sapiens_hsa052000.60007555
125Melanoma_Homo sapiens_hsa052180.59598263
126Colorectal cancer_Homo sapiens_hsa052100.58031920
127B cell receptor signaling pathway_Homo sapiens_hsa046620.57325654
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56921262
129Sphingolipid metabolism_Homo sapiens_hsa006000.56571583
130Renal cell carcinoma_Homo sapiens_hsa052110.55935531
131Steroid biosynthesis_Homo sapiens_hsa001000.55701780
132Choline metabolism in cancer_Homo sapiens_hsa052310.54295083
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.52259115
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51969927
135Glucagon signaling pathway_Homo sapiens_hsa049220.50936319
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49023300
137Dilated cardiomyopathy_Homo sapiens_hsa054140.46585547
138Ras signaling pathway_Homo sapiens_hsa040140.46398413
139Fatty acid metabolism_Homo sapiens_hsa012120.45921942
140VEGF signaling pathway_Homo sapiens_hsa043700.45022301
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44298910
142Endocytosis_Homo sapiens_hsa041440.43407244
143Lysosome_Homo sapiens_hsa041420.42254705
144Fatty acid biosynthesis_Homo sapiens_hsa000610.40304550
145Histidine metabolism_Homo sapiens_hsa003400.39930653
146Ether lipid metabolism_Homo sapiens_hsa005650.39715081
147MAPK signaling pathway_Homo sapiens_hsa040100.39417322
148Inositol phosphate metabolism_Homo sapiens_hsa005620.38834472
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.38774647
150Ovarian steroidogenesis_Homo sapiens_hsa049130.38667276
151Propanoate metabolism_Homo sapiens_hsa006400.38320366
152Phototransduction_Homo sapiens_hsa047440.38153552
153Tryptophan metabolism_Homo sapiens_hsa003800.37993223
154Alzheimers disease_Homo sapiens_hsa050100.36700273
155Rap1 signaling pathway_Homo sapiens_hsa040150.36696375
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36041378
157Mineral absorption_Homo sapiens_hsa049780.33102144
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32585756
159Type I diabetes mellitus_Homo sapiens_hsa049400.30389965
160Glycerolipid metabolism_Homo sapiens_hsa005610.29541970

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »