ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.57249883
2	proteasome assembly (GO:0043248)	4.35119044
3	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	4.32025500
4	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.99601053
5	termination of RNA polymerase III transcription (GO:0006386)	3.99601053
6	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.82885985
7	deoxyribonucleotide biosynthetic process (GO:0009263)	3.77724297
8	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.67070297
9	centriole assembly (GO:0098534)	3.63051940
10	rRNA modification (GO:0000154)	3.53191596
11	centriole replication (GO:0007099)	3.51540851
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46955228
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46955228
14	regulation of mitochondrial translation (GO:0070129)	3.46398516
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.42766252
16	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.37326033
17	DNA methylation involved in gamete generation (GO:0043046)	3.30169828
18	tRNA methylation (GO:0030488)	3.27832459
19	7-methylguanosine mRNA capping (GO:0006370)	3.23176186
20	7-methylguanosine RNA capping (GO:0009452)	3.21069199
21	RNA capping (GO:0036260)	3.21069199
22	maturation of 5.8S rRNA (GO:0000460)	3.20456089
23	piRNA metabolic process (GO:0034587)	3.19856279
24	termination of RNA polymerase I transcription (GO:0006363)	3.19124007
25	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	3.15725175
26	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.15089000
27	DNA-dependent DNA replication (GO:0006261)	3.14926776
28	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.14159175
29	RNA destabilization (GO:0050779)	3.13268471
30	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.13166498
31	transcription from RNA polymerase I promoter (GO:0006360)	3.12038741
32	ribosomal large subunit biogenesis (GO:0042273)	3.11524180
33	axonemal dynein complex assembly (GO:0070286)	3.10573978
34	kinetochore assembly (GO:0051382)	3.04733231
35	GTP biosynthetic process (GO:0006183)	3.03873629
36	DNA damage response, detection of DNA damage (GO:0042769)	3.02538498
37	microtubule depolymerization (GO:0007019)	3.02316066
38	DNA replication checkpoint (GO:0000076)	2.99316552
39	telomere maintenance via semi-conservative replication (GO:0032201)	2.98316913
40	RNA methylation (GO:0001510)	2.95718460
41	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.95133590
42	rRNA methylation (GO:0031167)	2.94783875
43	keratinocyte development (GO:0003334)	2.94533053
44	DNA double-strand break processing (GO:0000729)	2.94445297
45	ceramide catabolic process (GO:0046514)	2.94015621
46	epithelial cilium movement (GO:0003351)	2.88128490
47	CENP-A containing nucleosome assembly (GO:0034080)	2.87265339
48	telomere maintenance via recombination (GO:0000722)	2.81894859
49	mitochondrial DNA replication (GO:0006264)	2.81365430
50	DNA catabolic process, exonucleolytic (GO:0000738)	2.81106817
51	motile cilium assembly (GO:0044458)	2.80871865
52	transcription-coupled nucleotide-excision repair (GO:0006283)	2.77814424
53	chromatin remodeling at centromere (GO:0031055)	2.76717838
54	protein K6-linked ubiquitination (GO:0085020)	2.76579597
55	glycolipid catabolic process (GO:0019377)	2.76566609
56	natural killer cell activation involved in immune response (GO:0002323)	2.76135592
57	protein-cofactor linkage (GO:0018065)	2.75679256
58	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	2.73984398
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71088722
60	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.70071452
61	superoxide anion generation (GO:0042554)	2.69688257
62	DNA synthesis involved in DNA repair (GO:0000731)	2.68281028
63	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68093543
64	regulation of mitotic spindle checkpoint (GO:1903504)	2.68093543
65	synapsis (GO:0007129)	2.67713814
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67479412
67	ribosome assembly (GO:0042255)	2.65228275
68	kinetochore organization (GO:0051383)	2.64563602
69	guanosine-containing compound biosynthetic process (GO:1901070)	2.63951879
70	DNA ligation (GO:0006266)	2.63707644
71	tRNA modification (GO:0006400)	2.63383794
72	regulation of timing of cell differentiation (GO:0048505)	2.62917489
73	tRNA processing (GO:0008033)	2.61392317
74	ribonucleoprotein complex biogenesis (GO:0022613)	2.61360167
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.59283955
76	telomere maintenance via telomere lengthening (GO:0010833)	2.58790280
77	respiratory chain complex IV assembly (GO:0008535)	2.58441927
78	ribosomal small subunit biogenesis (GO:0042274)	2.58404431
79	GPI anchor biosynthetic process (GO:0006506)	2.56432543
80	cytochrome complex assembly (GO:0017004)	2.56073829
81	cilium movement (GO:0003341)	2.53792852
82	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.53404350
83	regulation of development, heterochronic (GO:0040034)	2.53045884
84	oligosaccharide catabolic process (GO:0009313)	2.52385559
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50624353
86	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.50171223
87	deoxyribose phosphate biosynthetic process (GO:0046385)	2.50171223
88	male meiosis (GO:0007140)	2.48257392
89	deoxyribonucleotide metabolic process (GO:0009262)	2.48076036
90	positive regulation of protein homodimerization activity (GO:0090073)	2.46819626
91	glycosphingolipid catabolic process (GO:0046479)	2.45503515
92	pseudouridine synthesis (GO:0001522)	2.45118584
93	amino sugar catabolic process (GO:0046348)	2.44836636
94	transcription elongation from RNA polymerase II promoter (GO:0006368)	2.44769076
95	spliceosomal snRNP assembly (GO:0000387)	2.44663205
96	UTP biosynthetic process (GO:0006228)	2.44413828
97	DNA integration (GO:0015074)	2.44133321
98	single strand break repair (GO:0000012)	2.44087396
99	negative regulation of telomere maintenance (GO:0032205)	2.43628326
100	ribosome biogenesis (GO:0042254)	2.42869046

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.80070308
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.66070427
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.53809969
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.07078240
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98128613
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.86028586
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75754888
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61196996
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61163515
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.60916590
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.59480399
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52695067
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52008970
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.38648301
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.37531249
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33397964
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12303350
18	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.11433075
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08347101
20	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.07931870
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.03046530
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.98159142
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.96066234
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.93396419
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.91041501
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.90735109
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.88611517
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.76123998
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.64479892
30	VDR_22108803_ChIP-Seq_LS180_Human	1.63014866
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.62648766
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60881199
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60502455
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59386250
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59025077
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54803048
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54357376
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51858044
39	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.50939397
40	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.50597923
41	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.50325293
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48151954
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.47986947
44	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.47834887
45	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.47834887
46	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.47834887
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47329566
48	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.47167773
49	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.46969226
50	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46313711
51	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.45118753
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.45081510
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.44046139
54	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.42274855
55	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.41734522
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.41134787
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40029026
58	P300_18555785_Chip-Seq_ESCs_Mouse	1.39969349
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.39423064
60	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.39295881
61	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.39114091
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.37642228
63	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.34635903
64	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.32793035
65	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.31771119
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31605488
67	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.30234908
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29645494
69	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.28974991
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28251877
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27332736
72	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.26145550
73	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.23459234
74	TTF2_22483619_ChIP-Seq_HELA_Human	1.22647240
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.22033348
76	PU1_27457419_Chip-Seq_LIVER_Mouse	1.19368127
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.16000824
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.15875695
79	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.14080935
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13814071
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13061540
82	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12934168
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11661114
84	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.10755145
85	FUS_26573619_Chip-Seq_HEK293_Human	1.08424319
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07324612
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06488151
88	MYC_18940864_ChIP-ChIP_HL60_Human	1.05724952
89	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04956341
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03860685
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.98717828
92	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98257151
93	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97571346
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96273131
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94405730
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92411121
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.89844046
98	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89389776
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85943986
100	EWS_26573619_Chip-Seq_HEK293_Human	0.85448603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.87872856
2	MP0000566_synostosis	3.65263777
3	MP0001188_hyperpigmentation	3.57498779
4	MP0003136_yellow_coat_color	3.49940317
5	MP0004381_abnormal_hair_follicle	3.06412434
6	MP0002277_abnormal_respiratory_mucosa	2.72550325
7	MP0008058_abnormal_DNA_repair	2.71597304
8	MP0003941_abnormal_skin_development	2.71449426
9	MP0008877_abnormal_DNA_methylation	2.39378688
10	MP0002102_abnormal_ear_morphology	2.33832717
11	MP0005409_darkened_coat_color	2.30740232
12	MP0003693_abnormal_embryo_hatching	2.29471355
13	MP0008057_abnormal_DNA_replication	2.26966133
14	MP0009379_abnormal_foot_pigmentation	2.19987012
15	MP0003786_premature_aging	2.17320836
16	MP0005171_absent_coat_pigmentation	2.16353746
17	MP0003718_maternal_effect	2.10708200
18	MP0003111_abnormal_nucleus_morphology	1.96394313
19	MP0010094_abnormal_chromosome_stability	1.85658664
20	MP0001986_abnormal_taste_sensitivity	1.85182284
21	MP0000015_abnormal_ear_pigmentation	1.77241931
22	MP0002160_abnormal_reproductive_system	1.74999442
23	MP0005410_abnormal_fertilization	1.73316315
24	MP0002132_abnormal_respiratory_system	1.62752448
25	MP0008932_abnormal_embryonic_tissue	1.61773879
26	MP0003880_abnormal_central_pattern	1.59303520
27	MP0008007_abnormal_cellular_replicative	1.51604329
28	MP0002210_abnormal_sex_determination	1.48643536
29	MP0002638_abnormal_pupillary_reflex	1.48527801
30	MP0004142_abnormal_muscle_tone	1.48247620
31	MP0008995_early_reproductive_senescence	1.46950384
32	MP0005075_abnormal_melanosome_morpholog	1.45398241
33	MP0005389_reproductive_system_phenotype	1.44583060
34	MP0008789_abnormal_olfactory_epithelium	1.39383152
35	MP0003077_abnormal_cell_cycle	1.32865008
36	MP0001919_abnormal_reproductive_system	1.31052341
37	MP0008260_abnormal_autophagy	1.30228500
38	MP0005174_abnormal_tail_pigmentation	1.26784126
39	MP0000372_irregular_coat_pigmentation	1.26320611
40	MP0001929_abnormal_gametogenesis	1.24599630
41	MP0003698_abnormal_male_reproductive	1.24282990
42	MP0005379_endocrine/exocrine_gland_phen	1.20263223
43	MP0000026_abnormal_inner_ear	1.18927901
44	MP0003315_abnormal_perineum_morphology	1.18444102
45	MP0000049_abnormal_middle_ear	1.17222608
46	MP0005645_abnormal_hypothalamus_physiol	1.15211753
47	MP0004133_heterotaxia	1.14663135
48	MP0002876_abnormal_thyroid_physiology	1.14076351
49	MP0003938_abnormal_ear_development	1.12096733
50	MP0005377_hearing/vestibular/ear_phenot	1.11174248
51	MP0003878_abnormal_ear_physiology	1.11174248
52	MP0000613_abnormal_salivary_gland	1.10921484
53	MP0005394_taste/olfaction_phenotype	1.10103427
54	MP0005499_abnormal_olfactory_system	1.10103427
55	MP0005451_abnormal_body_composition	1.09687690
56	MP0001145_abnormal_male_reproductive	1.09095276
57	MP0002095_abnormal_skin_pigmentation	1.08680699
58	MP0010386_abnormal_urinary_bladder	1.05404534
59	MP0002163_abnormal_gland_morphology	1.05377514
60	MP0002938_white_spotting	1.02153716
61	MP0001346_abnormal_lacrimal_gland	1.02137851
62	MP0006276_abnormal_autonomic_nervous	1.02069147
63	MP0000653_abnormal_sex_gland	1.00916955
64	MP0001186_pigmentation_phenotype	0.99078572
65	MP0002148_abnormal_hypersensitivity_rea	0.96506506
66	MP0005646_abnormal_pituitary_gland	0.96314859
67	MP0000678_abnormal_parathyroid_gland	0.95991335
68	MP0004957_abnormal_blastocyst_morpholog	0.95963074
69	MP0002249_abnormal_larynx_morphology	0.95381099
70	MP0004742_abnormal_vestibular_system	0.93666090
71	MP0005423_abnormal_somatic_nervous	0.93157666
72	MP0000762_abnormal_tongue_morphology	0.92773589
73	MP0001984_abnormal_olfaction	0.91666889
74	MP0009697_abnormal_copulation	0.90411270
75	MP0001905_abnormal_dopamine_level	0.90318891
76	MP0002751_abnormal_autonomic_nervous	0.88092875
77	MP0001529_abnormal_vocalization	0.87964172
78	MP0003724_increased_susceptibility_to	0.87458659
79	MP0001119_abnormal_female_reproductive	0.86358642
80	MP0001286_abnormal_eye_development	0.85784896
81	MP0000681_abnormal_thyroid_gland	0.84600171
82	MP0001963_abnormal_hearing_physiology	0.82331381
83	MP0003937_abnormal_limbs/digits/tail_de	0.80913180
84	MP0002098_abnormal_vibrissa_morphology	0.79896845
85	MP0002752_abnormal_somatic_nervous	0.78682419
86	MP0002177_abnormal_outer_ear	0.78115579
87	MP0000470_abnormal_stomach_morphology	0.77478693
88	MP0001486_abnormal_startle_reflex	0.75610170
89	MP0002233_abnormal_nose_morphology	0.75326504
90	MP0006072_abnormal_retinal_apoptosis	0.74610061
91	MP0003787_abnormal_imprinting	0.74216805
92	MP0000631_abnormal_neuroendocrine_gland	0.73719752
93	MP0001485_abnormal_pinna_reflex	0.73013551
94	MP0001853_heart_inflammation	0.72950362
95	MP0000647_abnormal_sebaceous_gland	0.72610897
96	MP0002075_abnormal_coat/hair_pigmentati	0.71590947
97	MP0010030_abnormal_orbit_morphology	0.67631762
98	MP0003890_abnormal_embryonic-extraembry	0.67610161
99	MP0003763_abnormal_thymus_physiology	0.66670882
100	MP0005551_abnormal_eye_electrophysiolog	0.65154875

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.84223898
2	Chromsome breakage (HP:0040012)	4.40856144
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.04962824
4	Absent/shortened dynein arms (HP:0200106)	4.04962824
5	Duplicated collecting system (HP:0000081)	3.53349378
6	Abnormal respiratory motile cilium morphology (HP:0005938)	3.43607380
7	Abnormal respiratory epithelium morphology (HP:0012253)	3.43607380
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.36323452
9	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.30380156
10	Abnormal ciliary motility (HP:0012262)	3.27416039
11	Abnormality of the renal collecting system (HP:0004742)	3.19897466
12	Progressive external ophthalmoplegia (HP:0000590)	3.16838184
13	Meckel diverticulum (HP:0002245)	2.96285093
14	Abnormality of the preputium (HP:0100587)	2.91037378
15	Abnormal respiratory motile cilium physiology (HP:0012261)	2.89587782
16	Septo-optic dysplasia (HP:0100842)	2.82932456
17	3-Methylglutaconic aciduria (HP:0003535)	2.77346433
18	Abnormality of the ileum (HP:0001549)	2.77319687
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.75786228
20	Birth length less than 3rd percentile (HP:0003561)	2.64383674
21	Optic nerve hypoplasia (HP:0000609)	2.62659502
22	Breast hypoplasia (HP:0003187)	2.61398188
23	Type I transferrin isoform profile (HP:0003642)	2.58507838
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.58243919
25	Microvesicular hepatic steatosis (HP:0001414)	2.47540825
26	Reticulocytopenia (HP:0001896)	2.46830885
27	Parakeratosis (HP:0001036)	2.43439625
28	Abnormality of chromosome stability (HP:0003220)	2.43111912
29	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.39806665
30	Clubbing of toes (HP:0100760)	2.36970587
31	True hermaphroditism (HP:0010459)	2.36850853
32	Median cleft lip (HP:0000161)	2.35115803
33	Upper limb muscle weakness (HP:0003484)	2.34569015
34	Triphalangeal thumb (HP:0001199)	2.31755374
35	Ectopic kidney (HP:0000086)	2.31376022
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.30009846
37	Supernumerary spleens (HP:0009799)	2.27797233
38	Conical tooth (HP:0000698)	2.25353159
39	Pancreatic cysts (HP:0001737)	2.24982175
40	Pancreatic fibrosis (HP:0100732)	2.23589409
41	Absent radius (HP:0003974)	2.21955136
42	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.20266148
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.20108191
44	Aplasia involving forearm bones (HP:0009822)	2.13386871
45	Absent forearm bone (HP:0003953)	2.13386871
46	Type 2 muscle fiber atrophy (HP:0003554)	2.11790393
47	Stomach cancer (HP:0012126)	2.10340912
48	Attenuation of retinal blood vessels (HP:0007843)	2.06902523
49	Bone marrow hypocellularity (HP:0005528)	2.05838458
50	Tubulointerstitial nephritis (HP:0001970)	2.05014142
51	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.04575273
52	Osteomalacia (HP:0002749)	2.04560703
53	Abnormality of the septum pellucidum (HP:0007375)	2.03067989
54	Renal Fanconi syndrome (HP:0001994)	2.01842212
55	Congenital sensorineural hearing impairment (HP:0008527)	2.00822907
56	Medial flaring of the eyebrow (HP:0010747)	1.97983176
57	Increased hepatocellular lipid droplets (HP:0006565)	1.97211510
58	Preaxial hand polydactyly (HP:0001177)	1.95641466
59	Exertional dyspnea (HP:0002875)	1.94074244
60	Facial cleft (HP:0002006)	1.93490643
61	Reduced antithrombin III activity (HP:0001976)	1.92716231
62	Abnormality of DNA repair (HP:0003254)	1.90524991
63	Absent thumb (HP:0009777)	1.87741060
64	Absent septum pellucidum (HP:0001331)	1.87219091
65	Small intestinal stenosis (HP:0012848)	1.84944103
66	Duodenal stenosis (HP:0100867)	1.84944103
67	Prolonged neonatal jaundice (HP:0006579)	1.84376343
68	Nephronophthisis (HP:0000090)	1.83914110
69	Renal cortical cysts (HP:0000803)	1.83596200
70	Acute necrotizing encephalopathy (HP:0006965)	1.83571820
71	Duplication of thumb phalanx (HP:0009942)	1.79301942
72	Prostate neoplasm (HP:0100787)	1.79009228
73	Mitochondrial inheritance (HP:0001427)	1.78682785
74	Abnormality of renal resorption (HP:0011038)	1.77418507
75	Optic disc pallor (HP:0000543)	1.76644005
76	Granulocytopenia (HP:0001913)	1.76056026
77	Abnormality of secondary sexual hair (HP:0009888)	1.75753317
78	Abnormality of the axillary hair (HP:0100134)	1.75753317
79	External ophthalmoplegia (HP:0000544)	1.74663748
80	Abnormal protein glycosylation (HP:0012346)	1.74401538
81	Abnormal glycosylation (HP:0012345)	1.74401538
82	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74401538
83	Abnormal protein N-linked glycosylation (HP:0012347)	1.74401538
84	Abnormality of incisor morphology (HP:0011063)	1.73476618
85	Postaxial foot polydactyly (HP:0001830)	1.72347536
86	Abnormality of the renal medulla (HP:0100957)	1.71707202
87	Rhinitis (HP:0012384)	1.71322327
88	Aganglionic megacolon (HP:0002251)	1.70623501
89	Horseshoe kidney (HP:0000085)	1.68598437
90	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.68304993
91	Hypoplasia of the fovea (HP:0007750)	1.68304993
92	Muscle fiber atrophy (HP:0100295)	1.67862535
93	Abnormal spermatogenesis (HP:0008669)	1.67502623
94	Male pseudohermaphroditism (HP:0000037)	1.66705207
95	Cerebral hypomyelination (HP:0006808)	1.66345294
96	Patellar aplasia (HP:0006443)	1.65811597
97	Oligohydramnios (HP:0001562)	1.65238213
98	Decreased central vision (HP:0007663)	1.63509357
99	Nephrogenic diabetes insipidus (HP:0009806)	1.63355468
100	Cleft eyelid (HP:0000625)	1.60805797

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	IRAK3	5.39104466
2	STK16	4.16040014
3	PLK4	3.58553149
4	IRAK4	3.26350194
5	ZAK	3.12265186
6	SRPK1	2.75657623
7	BUB1	2.62223740
8	CASK	2.62029110
9	IRAK2	2.55759649
10	IRAK1	2.53498875
11	PBK	2.02048911
12	MARK1	2.00429165
13	MKNK2	1.97233797
14	EIF2AK1	1.89826437
15	EIF2AK3	1.82802875
16	TNIK	1.74764033
17	EIF2AK2	1.56754969
18	TLK1	1.55807968
19	MKNK1	1.52727452
20	VRK1	1.43587920
21	ADRBK2	1.38654597
22	STK38L	1.37086688
23	EPHA2	1.34097159
24	BLK	1.32628680
25	BMPR2	1.31349372
26	NEK6	1.27275843
27	TXK	1.25873231
28	GRK1	1.19734123
29	WEE1	1.15000410
30	TTK	1.13159067
31	BMPR1B	1.11624376
32	MAP2K7	1.09604156
33	YES1	1.07564128
34	AKT3	1.05393393
35	DYRK3	0.97352630
36	PLK3	0.95984941
37	NLK	0.95098548
38	PRPF4B	0.93502848
39	MAP3K14	0.92964060
40	MUSK	0.91413200
41	DYRK2	0.90572892
42	NME1	0.87034154
43	CLK1	0.87017306
44	CDK3	0.83622901
45	PNCK	0.83559392
46	ATR	0.80538753
47	PLK1	0.79347248
48	MAP3K12	0.78794249
49	NUAK1	0.76359087
50	CHEK2	0.75752191
51	GRK7	0.73715954
52	TSSK6	0.72789006
53	INSRR	0.68482283
54	TEC	0.65425071
55	SIK3	0.64393358
56	BRAF	0.64389882
57	RPS6KA5	0.62841481
58	PINK1	0.61240448
59	PIM2	0.61031290
60	BRD4	0.59978115
61	IKBKB	0.59825391
62	STK24	0.58902389
63	CDC7	0.58076238
64	EPHA3	0.56288469
65	PKN1	0.54566195
66	MAPK13	0.53363563
67	CDK19	0.52112987
68	NME2	0.51943738
69	AURKA	0.51777764
70	PLK2	0.50769884
71	MST4	0.50432540
72	PRKCI	0.50313957
73	TNK2	0.50272965
74	BCR	0.50230118
75	TESK2	0.47571400
76	ERBB3	0.45498652
77	CAMK2B	0.45436611
78	MAPK15	0.44473486
79	CSNK2A1	0.42615919
80	ATM	0.41331926
81	STK4	0.41159253
82	CDK7	0.39716374
83	IKBKE	0.37552172
84	CDK8	0.37513408
85	AURKB	0.37143213
86	STK39	0.36036939
87	CAMK2D	0.35524832
88	PRKCE	0.35463593
89	MAPK7	0.32637213
90	MAP2K6	0.32250297
91	PDK2	0.30920632
92	CHEK1	0.30524738
93	LYN	0.30272825
94	DYRK1A	0.29707325
95	TESK1	0.29203185
96	CSNK2A2	0.29049008
97	OXSR1	0.27601777
98	CAMK2G	0.27582411
99	CDC42BPA	0.26182756
100	FES	0.24412035

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.55213047
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.42899011
3	Homologous recombination_Homo sapiens_hsa03440	3.05902080
4	Proteasome_Homo sapiens_hsa03050	2.98852483
5	DNA replication_Homo sapiens_hsa03030	2.81266383
6	Ribosome_Homo sapiens_hsa03010	2.78845881
7	Mismatch repair_Homo sapiens_hsa03430	2.53351705
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.45815268
9	Basal transcription factors_Homo sapiens_hsa03022	2.42016438
10	Protein export_Homo sapiens_hsa03060	2.39366194
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.31043011
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.14919743
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.05171697
14	Spliceosome_Homo sapiens_hsa03040	2.01980601
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.91216741
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.75056740
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.73182412
18	Base excision repair_Homo sapiens_hsa03410	1.63350897
19	Purine metabolism_Homo sapiens_hsa00230	1.59799082
20	Huntingtons disease_Homo sapiens_hsa05016	1.54205978
21	Sphingolipid metabolism_Homo sapiens_hsa00600	1.50242144
22	RNA degradation_Homo sapiens_hsa03018	1.45830000
23	Phototransduction_Homo sapiens_hsa04744	1.43596893
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.42731011
25	Parkinsons disease_Homo sapiens_hsa05012	1.40115739
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.37533586
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.36881017
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.32925440
29	RNA transport_Homo sapiens_hsa03013	1.30962686
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.26914118
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.25125273
32	One carbon pool by folate_Homo sapiens_hsa00670	1.23350764
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22241879
34	Allograft rejection_Homo sapiens_hsa05330	1.20420961
35	Cell cycle_Homo sapiens_hsa04110	1.13460528
36	p53 signaling pathway_Homo sapiens_hsa04115	1.10306403
37	Other glycan degradation_Homo sapiens_hsa00511	1.07117982
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02790728
39	Alzheimers disease_Homo sapiens_hsa05010	0.99248728
40	Ether lipid metabolism_Homo sapiens_hsa00565	0.96567814
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.95891632
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.95691919
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91142223
44	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90112410
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88891205
46	Asthma_Homo sapiens_hsa05310	0.86565317
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85868156
48	Regulation of autophagy_Homo sapiens_hsa04140	0.81525159
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81092727
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80720568
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.80009896
52	Nicotine addiction_Homo sapiens_hsa05033	0.78874105
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.78025119
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75667965
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.75545028
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75163990
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72377137
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70780781
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70767889
60	Glutathione metabolism_Homo sapiens_hsa00480	0.68044341
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67772075
62	Herpes simplex infection_Homo sapiens_hsa05168	0.64192611
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62532979
64	Measles_Homo sapiens_hsa05162	0.61292797
65	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60244398
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.57954781
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54038430
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53804528
69	Pancreatic secretion_Homo sapiens_hsa04972	0.53679116
70	Metabolic pathways_Homo sapiens_hsa01100	0.52139514
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50562220
72	Folate biosynthesis_Homo sapiens_hsa00790	0.50304419
73	Taste transduction_Homo sapiens_hsa04742	0.49719625
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49089058
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47121436
76	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46926428
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46336790
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45787132
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44106805
80	Serotonergic synapse_Homo sapiens_hsa04726	0.37629186
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36861750
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35038576
83	Retinol metabolism_Homo sapiens_hsa00830	0.34811770
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.34657468
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.33140009
86	Influenza A_Homo sapiens_hsa05164	0.30547333
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.25625606
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24061693
89	Malaria_Homo sapiens_hsa05144	0.23456982
90	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.22689712
91	Phagosome_Homo sapiens_hsa04145	0.22590467
92	Mineral absorption_Homo sapiens_hsa04978	0.22177450
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22098738
94	Fatty acid elongation_Homo sapiens_hsa00062	0.21654716
95	Circadian rhythm_Homo sapiens_hsa04710	0.20047221
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.20046062
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.18906846
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.18627985
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.18514484
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.18256893

TMEM30C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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