TMEM33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.23220173
2central nervous system myelination (GO:0022010)7.23220173
3fatty acid elongation (GO:0030497)6.09390438
4L-phenylalanine catabolic process (GO:0006559)5.15621101
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.15621101
6L-phenylalanine metabolic process (GO:0006558)4.81296137
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.81296137
8DNA double-strand break processing (GO:0000729)4.55455659
9lactate metabolic process (GO:0006089)4.49923341
10long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.39840793
11fatty-acyl-CoA biosynthetic process (GO:0046949)4.34098206
12cholesterol biosynthetic process (GO:0006695)4.31410837
13ensheathment of neurons (GO:0007272)4.27242039
14axon ensheathment (GO:0008366)4.27242039
15myelination (GO:0042552)4.26953065
16negative regulation of neurotransmitter secretion (GO:0046929)4.10845281
17heme transport (GO:0015886)3.99047903
18proteasome assembly (GO:0043248)3.96538989
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.95390092
20glyoxylate metabolic process (GO:0046487)3.94998434
21response to methylmercury (GO:0051597)3.94967572
22respiratory chain complex IV assembly (GO:0008535)3.93109649
23regulation of glucokinase activity (GO:0033131)3.90657799
24regulation of hexokinase activity (GO:1903299)3.90657799
25very long-chain fatty acid metabolic process (GO:0000038)3.89407698
26fatty-acyl-CoA metabolic process (GO:0035337)3.83481391
27cysteine metabolic process (GO:0006534)3.81095648
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.80793300
29thioester biosynthetic process (GO:0035384)3.80357580
30acyl-CoA biosynthetic process (GO:0071616)3.80357580
31sterol biosynthetic process (GO:0016126)3.78231667
32negative regulation of neurotransmitter transport (GO:0051589)3.72891896
33replication fork processing (GO:0031297)3.72682968
34aromatic amino acid family catabolic process (GO:0009074)3.62010203
35cullin deneddylation (GO:0010388)3.61092915
36proline metabolic process (GO:0006560)3.59338078
37synapsis (GO:0007129)3.58989589
38alpha-linolenic acid metabolic process (GO:0036109)3.57763699
39inositol phosphate catabolic process (GO:0071545)3.53810962
40sulfur amino acid catabolic process (GO:0000098)3.52926890
41positive regulation of protein autophosphorylation (GO:0031954)3.50693128
42signal peptide processing (GO:0006465)3.47863746
43keratinocyte development (GO:0003334)3.45903782
44water-soluble vitamin biosynthetic process (GO:0042364)3.45900787
45iron coordination entity transport (GO:1901678)3.43407348
46ketone body metabolic process (GO:1902224)3.40842307
47asymmetric protein localization (GO:0008105)3.39844566
48cytochrome complex assembly (GO:0017004)3.37590407
49L-serine metabolic process (GO:0006563)3.37354186
50proline biosynthetic process (GO:0006561)3.36649193
51bile acid biosynthetic process (GO:0006699)3.35109097
52establishment of mitochondrion localization (GO:0051654)3.33429017
53response to pheromone (GO:0019236)3.25630468
54protein deneddylation (GO:0000338)3.24216681
55serine family amino acid biosynthetic process (GO:0009070)3.23859403
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20561240
57regulation of mitotic spindle checkpoint (GO:1903504)3.20561240
58somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.19692752
59isotype switching (GO:0045190)3.19692752
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.19692752
61myelin maintenance (GO:0043217)3.19264642
62glutamate metabolic process (GO:0006536)3.19109417
63very-low-density lipoprotein particle assembly (GO:0034379)3.18920995
64protein K6-linked ubiquitination (GO:0085020)3.17101513
65polyol catabolic process (GO:0046174)3.12844601
66prenylation (GO:0097354)3.10552454
67protein prenylation (GO:0018342)3.10552454
68regulation of DNA endoreduplication (GO:0032875)3.08437947
69platelet dense granule organization (GO:0060155)3.06135496
70L-amino acid import (GO:0043092)3.05297280
71bile acid metabolic process (GO:0008206)3.02496625
72histone exchange (GO:0043486)3.02150722
73thioester metabolic process (GO:0035383)3.01565919
74acyl-CoA metabolic process (GO:0006637)3.01565919
75glycerophospholipid catabolic process (GO:0046475)2.98851704
76chromatin remodeling at centromere (GO:0031055)2.97330421
77positive regulation of glycoprotein biosynthetic process (GO:0010560)2.97222014
78RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96854369
79aspartate family amino acid catabolic process (GO:0009068)2.94795273
80phosphorylated carbohydrate dephosphorylation (GO:0046838)2.94781284
81inositol phosphate dephosphorylation (GO:0046855)2.94781284
82acetyl-CoA metabolic process (GO:0006084)2.94185248
83neuron cell-cell adhesion (GO:0007158)2.93764502
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.92361976
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89262112
86CENP-A containing nucleosome assembly (GO:0034080)2.88556227
87glutamine family amino acid biosynthetic process (GO:0009084)2.87330498
88positive regulation of cellular amine metabolic process (GO:0033240)2.86651382
89dicarboxylic acid catabolic process (GO:0043649)2.85799113
90response to lead ion (GO:0010288)2.85706948
91apical protein localization (GO:0045176)2.83331338
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.83112462
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83112462
94magnesium ion transport (GO:0015693)2.83022184
95short-chain fatty acid metabolic process (GO:0046459)2.82986147
96branched-chain amino acid catabolic process (GO:0009083)2.82438812
97DNA catabolic process, exonucleolytic (GO:0000738)2.81854541
98opsonization (GO:0008228)2.81437616
99regulation of meiosis I (GO:0060631)2.80260031
100telomere maintenance via telomerase (GO:0007004)2.80024194
101oligodendrocyte differentiation (GO:0048709)2.79658479
102serine family amino acid metabolic process (GO:0009069)2.78952026
103import into cell (GO:0098657)2.78552532
104non-recombinational repair (GO:0000726)2.78526968
105double-strand break repair via nonhomologous end joining (GO:0006303)2.78526968
106transmission of nerve impulse (GO:0019226)2.76681842
107glutathione biosynthetic process (GO:0006750)2.76252027
108double-strand break repair via homologous recombination (GO:0000724)2.75656181
109recombinational repair (GO:0000725)2.75055653
110histone H2A acetylation (GO:0043968)2.74657325
111protein K11-linked deubiquitination (GO:0035871)2.74596538
112long-chain fatty acid biosynthetic process (GO:0042759)2.74543907
113drug transmembrane transport (GO:0006855)2.74373749
114mitotic sister chromatid cohesion (GO:0007064)2.74325620
115kidney morphogenesis (GO:0060993)2.73899080
116protein localization to endosome (GO:0036010)2.73761007
117zinc ion transport (GO:0006829)2.73127013
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.73113087
119melanin biosynthetic process (GO:0042438)2.71870263
120positive regulation of glycolytic process (GO:0045821)2.70432685
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70049940
122negative regulation of neurological system process (GO:0031645)2.68832751
123proline transport (GO:0015824)2.68473492
124regulation of lipoprotein metabolic process (GO:0050746)2.68324641
125protein targeting to lysosome (GO:0006622)2.65840267
126establishment of protein localization to vacuole (GO:0072666)2.65840267
127protein targeting to vacuole (GO:0006623)2.65840267
128secondary metabolite biosynthetic process (GO:0044550)2.64007697
129presynaptic membrane assembly (GO:0097105)2.63791579
130cholesterol efflux (GO:0033344)2.63259470
131astrocyte development (GO:0014002)2.61705268
132peptidyl-cysteine modification (GO:0018198)2.61181233
133isoprenoid biosynthetic process (GO:0008299)2.60632907
134gamma-aminobutyric acid transport (GO:0015812)2.59672514
135substantia nigra development (GO:0021762)2.59560465
136DNA deamination (GO:0045006)2.59422789
137coenzyme catabolic process (GO:0009109)2.59303019
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59125537
139nonribosomal peptide biosynthetic process (GO:0019184)2.58797750
140nucleotide transmembrane transport (GO:1901679)2.58436661
141regulation of cholesterol biosynthetic process (GO:0045540)2.58355944
142atrial cardiac muscle cell action potential (GO:0086014)2.58006632
143female gonad development (GO:0008585)2.57737881
144aromatic amino acid family metabolic process (GO:0009072)2.57297274
145cholesterol metabolic process (GO:0008203)2.57295219
146DNA replication-dependent nucleosome organization (GO:0034723)2.57234717
147DNA replication-dependent nucleosome assembly (GO:0006335)2.57234717
148regulation of acyl-CoA biosynthetic process (GO:0050812)2.57194024
149axon development (GO:0061564)2.56715557
150presynaptic membrane organization (GO:0097090)2.55512659
151mannosylation (GO:0097502)2.55469577
152maturation of 5.8S rRNA (GO:0000460)2.54608092
153response to X-ray (GO:0010165)2.54197837
154regulation of sulfur metabolic process (GO:0042762)2.53613665
155regulation of translation, ncRNA-mediated (GO:0045974)2.52579913
156negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52579913
157negative regulation of translation, ncRNA-mediated (GO:0040033)2.52579913
158mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.52379630
159resolution of meiotic recombination intermediates (GO:0000712)2.51688742
160cellular ketone body metabolic process (GO:0046950)2.51457430
161L-fucose catabolic process (GO:0042355)2.51443722
162fucose catabolic process (GO:0019317)2.51443722
163L-fucose metabolic process (GO:0042354)2.51443722
164nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50504870
165cellular amino acid catabolic process (GO:0009063)2.49753223
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49693643
167triglyceride biosynthetic process (GO:0019432)2.49278299
168protein localization to vacuole (GO:0072665)2.49274304
169protein localization to lysosome (GO:0061462)2.49274304
170tyrosine metabolic process (GO:0006570)2.49009124
171regulation of protein autophosphorylation (GO:0031952)2.48956339
172neuronal action potential propagation (GO:0019227)2.48942614
173DNA replication checkpoint (GO:0000076)2.48302392
174protein complex biogenesis (GO:0070271)2.46561475
175glutathione derivative metabolic process (GO:1901685)2.45639067
176glutathione derivative biosynthetic process (GO:1901687)2.45639067
177negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.45307163
178regulation of centriole replication (GO:0046599)2.45295272
179glycosylceramide metabolic process (GO:0006677)2.45175104
180positive regulation of glycoprotein metabolic process (GO:1903020)2.44776203
181alpha-amino acid catabolic process (GO:1901606)2.43613151
182neurotransmitter uptake (GO:0001504)2.43049673
183somatic recombination of immunoglobulin gene segments (GO:0016447)2.42162001
184cofactor catabolic process (GO:0051187)2.42003017
185preassembly of GPI anchor in ER membrane (GO:0016254)2.41925872
186regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.41447729
187negative regulation of response to reactive oxygen species (GO:1901032)2.41096093
188negative regulation of DNA recombination (GO:0045910)2.41072213
189mitochondrial respiratory chain complex assembly (GO:0033108)2.39741607
190C-terminal protein lipidation (GO:0006501)2.36419674
191dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35386482
192somatic diversification of immunoglobulins (GO:0016445)2.35211193
193regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.35151835
194developmental pigmentation (GO:0048066)2.34453927
195spindle checkpoint (GO:0031577)2.33643695
196attachment of spindle microtubules to kinetochore (GO:0008608)2.33537022
197positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33156054
198positive regulation of mitotic sister chromatid separation (GO:1901970)2.33156054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.82696633
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.74354941
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.40909192
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21537047
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.84383601
6GBX2_23144817_ChIP-Seq_PC3_Human2.81115269
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.66391953
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49946536
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.39949606
10TAF15_26573619_Chip-Seq_HEK293_Human2.35035864
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.32747633
12E2F7_22180533_ChIP-Seq_HELA_Human2.30463622
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29187245
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26444557
15ELK1_19687146_ChIP-ChIP_HELA_Human2.20116182
16* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18440408
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.17905502
18AR_21572438_ChIP-Seq_LNCaP_Human2.14194327
19* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11977085
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.11933942
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11351215
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10289211
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09525080
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08192045
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05715482
26* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98429201
27IGF1R_20145208_ChIP-Seq_DFB_Human1.93021897
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89377065
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88468995
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87339947
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84508897
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84219276
33HTT_18923047_ChIP-ChIP_STHdh_Human1.78590353
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77472405
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.76050780
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74187333
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70669415
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.67502516
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64771050
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60561831
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60561831
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59888936
43EOMES_21245162_ChIP-Seq_HESCs_Human1.57705592
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56414812
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56386939
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.56045938
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54190974
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50953519
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.49261666
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48857608
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48755049
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48214400
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47390115
54VDR_23849224_ChIP-Seq_CD4+_Human1.46171814
55REST_21632747_ChIP-Seq_MESCs_Mouse1.45872534
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.44988068
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44667902
58FUS_26573619_Chip-Seq_HEK293_Human1.43487714
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43046495
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42909992
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.41855238
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.41288659
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40117849
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.39920971
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35755735
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35755735
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35704316
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35260003
69BCAT_22108803_ChIP-Seq_LS180_Human1.34464829
70CBP_20019798_ChIP-Seq_JUKART_Human1.33824011
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33824011
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.33688165
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32778308
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31248190
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30995271
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.30960698
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30533060
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29444014
79* MYC_18940864_ChIP-ChIP_HL60_Human1.29412958
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28504605
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28098489
82* AR_25329375_ChIP-Seq_VCAP_Human1.27064872
83ZNF274_21170338_ChIP-Seq_K562_Hela1.27007732
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26996755
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26292521
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26018725
87* P53_22387025_ChIP-Seq_ESCs_Mouse1.25580183
88* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25081066
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25024821
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23948702
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.23778989
92P300_19829295_ChIP-Seq_ESCs_Human1.23076968
93SOX2_19829295_ChIP-Seq_ESCs_Human1.22968393
94NANOG_19829295_ChIP-Seq_ESCs_Human1.22968393
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22094885
96P300_18555785_Chip-Seq_ESCs_Mouse1.22079645
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21691416
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21377675
99* TCF4_22108803_ChIP-Seq_LS180_Human1.20201102
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.19978056
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.18595404
102ER_23166858_ChIP-Seq_MCF-7_Human1.18331340
103CDX2_22108803_ChIP-Seq_LS180_Human1.17129280
104* SRF_21415370_ChIP-Seq_HL-1_Mouse1.17073644
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16966256
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.16019796
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15440138
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.15022286
109IRF1_19129219_ChIP-ChIP_H3396_Human1.14142235
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11859944
111TCF4_23295773_ChIP-Seq_U87_Human1.10926103
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10626153
113* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10496851
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09926733
115FOXP3_21729870_ChIP-Seq_TREG_Human1.09851122
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.09830422
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09257597
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.08308843
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07382084
120TP53_22573176_ChIP-Seq_HFKS_Human1.06792633
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06453268
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06370949
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.06359902
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06104285
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06074183
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05940352
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05634030
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05599163
129* ETS1_20019798_ChIP-Seq_JURKAT_Human1.04733803
130CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04614192
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04467724
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.02738634
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01800474
134FOXA1_25329375_ChIP-Seq_VCAP_Human1.01594328
135FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01594328
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01169848
137* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00978476
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00892852
139ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00605533
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.00331811
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99575666
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98987738
143EWS_26573619_Chip-Seq_HEK293_Human0.98631624
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98123421
145* EZH2_27304074_Chip-Seq_ESCs_Mouse0.96669185
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94464912
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94212268
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92416879
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92194267
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.91892042
151* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91519592
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91346009
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91035734
154STAT3_23295773_ChIP-Seq_U87_Human0.90877477
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90184192
156JUN_21703547_ChIP-Seq_K562_Human0.87738881
157FOXA2_19822575_ChIP-Seq_HepG2_Human0.87695274
158* VDR_22108803_ChIP-Seq_LS180_Human0.87424651
159SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87143391
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.86898890
161CBP_21632823_ChIP-Seq_H3396_Human0.86004370
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82185594
163TET1_21490601_ChIP-Seq_MESCs_Mouse0.81395892
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.81310080
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81230589
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81126212
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80694624
168TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78212888
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77906568
170TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77793821
171FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75619004
172NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75137657
173* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.74509736
174RING1B_27294783_Chip-Seq_ESCs_Mouse0.74379754
175* RNF2_27304074_Chip-Seq_ESCs_Mouse0.73492606
176SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73118778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.22823286
2MP0002139_abnormal_hepatobiliary_system3.90583922
3MP0000920_abnormal_myelination3.62366947
4MP0002102_abnormal_ear_morphology3.54549622
5MP0005360_urolithiasis3.50938496
6MP0003329_amyloid_beta_deposits3.26125881
7MP0003806_abnormal_nucleotide_metabolis3.24370415
8MP0005085_abnormal_gallbladder_physiolo3.23245433
9MP0008877_abnormal_DNA_methylation3.04181975
10MP0003880_abnormal_central_pattern3.00239815
11MP0005365_abnormal_bile_salt2.79479079
12MP0005171_absent_coat_pigmentation2.76925030
13MP0003690_abnormal_glial_cell2.74610152
14MP0004859_abnormal_synaptic_plasticity2.61546046
15MP0010234_abnormal_vibrissa_follicle2.60925524
16MP0004270_analgesia2.59818970
17MP0008058_abnormal_DNA_repair2.56791103
18MP0003656_abnormal_erythrocyte_physiolo2.54408719
19MP0008875_abnormal_xenobiotic_pharmacok2.52126544
20MP0002938_white_spotting2.48231620
21MP0002837_dystrophic_cardiac_calcinosis2.46708662
22MP0005075_abnormal_melanosome_morpholog2.34607353
23MP0008057_abnormal_DNA_replication2.32697320
24MP0010094_abnormal_chromosome_stability2.32099593
25MP0004885_abnormal_endolymph2.26012423
26MP0003787_abnormal_imprinting2.23954684
27MP0002064_seizures2.14028612
28MP0009046_muscle_twitch2.09051334
29MP0003195_calcinosis2.05009228
30MP0000604_amyloidosis2.04621958
31MP0005332_abnormal_amino_acid2.01705649
32MP0006072_abnormal_retinal_apoptosis1.99481653
33MP0001529_abnormal_vocalization1.97978125
34MP0003634_abnormal_glial_cell1.93981274
35MP0004142_abnormal_muscle_tone1.93334595
36MP0002272_abnormal_nervous_system1.91175462
37MP0005253_abnormal_eye_physiology1.87516362
38MP0005058_abnormal_lysosome_morphology1.86307934
39MP0006054_spinal_hemorrhage1.84896026
40MP0003635_abnormal_synaptic_transmissio1.82582516
41MP0001485_abnormal_pinna_reflex1.82034323
42MP0001486_abnormal_startle_reflex1.81140885
43MP0003718_maternal_effect1.81095857
44MP0003890_abnormal_embryonic-extraembry1.74669916
45MP0005367_renal/urinary_system_phenotyp1.73573707
46MP0000516_abnormal_urinary_system1.73573707
47MP0003786_premature_aging1.69333647
48MP0000427_abnormal_hair_cycle1.68962210
49MP0004147_increased_porphyrin_level1.64655992
50MP0003632_abnormal_nervous_system1.62437524
51MP0009745_abnormal_behavioral_response1.62190728
52MP0002063_abnormal_learning/memory/cond1.62030848
53MP0003121_genomic_imprinting1.61182568
54MP0000015_abnormal_ear_pigmentation1.59308993
55MP0009840_abnormal_foam_cell1.55533981
56MP0000778_abnormal_nervous_system1.52592359
57MP0005174_abnormal_tail_pigmentation1.52181027
58MP0001324_abnormal_eye_pigmentation1.50254254
59MP0000569_abnormal_digit_pigmentation1.49689563
60MP0009780_abnormal_chondrocyte_physiolo1.49682669
61MP0003633_abnormal_nervous_system1.48841874
62MP0001984_abnormal_olfaction1.48303055
63MP0003631_nervous_system_phenotype1.48126649
64MP0003172_abnormal_lysosome_physiology1.47253894
65MP0000647_abnormal_sebaceous_gland1.44631022
66MP0001666_abnormal_nutrient_absorption1.44344544
67MP0002751_abnormal_autonomic_nervous1.42545510
68MP0002572_abnormal_emotion/affect_behav1.41949754
69MP0002229_neurodegeneration1.41620154
70MP0000955_abnormal_spinal_cord1.38997631
71MP0005584_abnormal_enzyme/coenzyme_acti1.37997792
72MP0003122_maternal_imprinting1.37828555
73MP0003252_abnormal_bile_duct1.37632633
74MP0009697_abnormal_copulation1.36326383
75MP0002254_reproductive_system_inflammat1.34326719
76MP0002734_abnormal_mechanical_nocicepti1.33634133
77MP0005379_endocrine/exocrine_gland_phen1.32979430
78MP0005083_abnormal_biliary_tract1.32695858
79MP0000639_abnormal_adrenal_gland1.32116534
80MP0002095_abnormal_skin_pigmentation1.31149446
81MP0005645_abnormal_hypothalamus_physiol1.30390464
82MP0008007_abnormal_cellular_replicative1.27909762
83MP0003111_abnormal_nucleus_morphology1.27269492
84MP0002118_abnormal_lipid_homeostasis1.27267354
85MP0003950_abnormal_plasma_membrane1.25955332
86MP0004043_abnormal_pH_regulation1.24893330
87MP0002909_abnormal_adrenal_gland1.24701743
88MP0003693_abnormal_embryo_hatching1.24251044
89MP0000462_abnormal_digestive_system1.21066483
90MP0010329_abnormal_lipoprotein_level1.20735215
91MP0001905_abnormal_dopamine_level1.17759416
92MP0003283_abnormal_digestive_organ1.17520199
93MP0005386_behavior/neurological_phenoty1.17151772
94MP0004924_abnormal_behavior1.17151772
95MP0003075_altered_response_to1.15168672
96MP0000013_abnormal_adipose_tissue1.14644095
97MP0002066_abnormal_motor_capabilities/c1.13622989
98MP0002638_abnormal_pupillary_reflex1.12131968
99MP0004019_abnormal_vitamin_homeostasis1.10816521
100MP0004957_abnormal_blastocyst_morpholog1.10767338
101MP0004134_abnormal_chest_morphology1.08808023
102MP0004215_abnormal_myocardial_fiber1.08246734
103MP0000371_diluted_coat_color1.07723029
104MP0001440_abnormal_grooming_behavior1.07472885
105MP0002067_abnormal_sensory_capabilities1.07165840
106MP0004742_abnormal_vestibular_system1.06762873
107MP0002009_preneoplasia1.06479700
108MP0005187_abnormal_penis_morphology1.03600538
109MP0002882_abnormal_neuron_morphology1.03156192
110MP0002733_abnormal_thermal_nociception1.02820740
111MP0003941_abnormal_skin_development1.01924229
112MP0002163_abnormal_gland_morphology1.01631731
113MP0001970_abnormal_pain_threshold0.98267271
114MP0005423_abnormal_somatic_nervous0.96759507
115MP0003119_abnormal_digestive_system0.96364683
116MP0005248_abnormal_Harderian_gland0.95182677
117MP0001177_atelectasis0.95152206
118MP0003646_muscle_fatigue0.94178940
119MP0008872_abnormal_physiological_respon0.93324883
120MP0001188_hyperpigmentation0.93289793
121MP0005395_other_phenotype0.92732538
122MP0003011_delayed_dark_adaptation0.92580746
123MP0003937_abnormal_limbs/digits/tail_de0.92391426
124MP0003136_yellow_coat_color0.92231822
125MP0002876_abnormal_thyroid_physiology0.91471488
126MP0003868_abnormal_feces_composition0.90651393
127MP0000631_abnormal_neuroendocrine_gland0.89278884
128MP0005551_abnormal_eye_electrophysiolog0.89097689
129MP0001929_abnormal_gametogenesis0.89077223
130MP0006292_abnormal_olfactory_placode0.89073476
131MP0004133_heterotaxia0.88642244
132MP0003186_abnormal_redox_activity0.88596291
133MP0001944_abnormal_pancreas_morphology0.88516985
134MP0010352_gastrointestinal_tract_polyps0.87511562
135MP0002160_abnormal_reproductive_system0.85564563
136MP0000383_abnormal_hair_follicle0.85360115
137MP0005084_abnormal_gallbladder_morpholo0.85055586
138MP0003123_paternal_imprinting0.83939324
139MP0002736_abnormal_nociception_after0.83771207
140MP0006035_abnormal_mitochondrial_morpho0.83746180
141MP0010307_abnormal_tumor_latency0.83646361
142MP0008569_lethality_at_weaning0.82009965
143MP0002693_abnormal_pancreas_physiology0.81465755
144MP0005389_reproductive_system_phenotype0.81184947
145MP0001968_abnormal_touch/_nociception0.79371967
146MP0003567_abnormal_fetal_cardiomyocyte0.78855725
147MP0005646_abnormal_pituitary_gland0.78525441
148MP0004811_abnormal_neuron_physiology0.77883949
149MP0000653_abnormal_sex_gland0.77126862
150MP0008932_abnormal_embryonic_tissue0.76435738
151MP0010678_abnormal_skin_adnexa0.76151997
152MP0002152_abnormal_brain_morphology0.76147315
153MP0003137_abnormal_impulse_conducting0.76025607
154MP0005391_vision/eye_phenotype0.74716809
155MP0001963_abnormal_hearing_physiology0.73527250
156MP0001502_abnormal_circadian_rhythm0.71833387
157MP0002090_abnormal_vision0.70706618
158MP0001661_extended_life_span0.70551760
159MP0000747_muscle_weakness0.69537105
160MP0002295_abnormal_pulmonary_circulatio0.69358221
161MP0001299_abnormal_eye_distance/0.65876262
162MP0005195_abnormal_posterior_eye0.65406377
163MP0005636_abnormal_mineral_homeostasis0.64500999
164MP0001764_abnormal_homeostasis0.63934886
165MP0005220_abnormal_exocrine_pancreas0.63910854
166MP0005408_hypopigmentation0.63506041
167MP0006036_abnormal_mitochondrial_physio0.62495383
168MP0002282_abnormal_trachea_morphology0.60877649
169MP0001340_abnormal_eyelid_morphology0.60619175
170MP0002752_abnormal_somatic_nervous0.60590183
171MP0000609_abnormal_liver_physiology0.60320973
172MP0003638_abnormal_response/metabolism_0.59323352
173MP0002557_abnormal_social/conspecific_i0.57921941

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.90847059
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23607851
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.23607851
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.21631557
5Intrahepatic cholestasis (HP:0001406)3.79991553
6Cerebral inclusion bodies (HP:0100314)3.70736097
7Hypobetalipoproteinemia (HP:0003563)3.51281386
8Hypothermia (HP:0002045)3.50476435
9Intention tremor (HP:0002080)3.46815492
10Clumsiness (HP:0002312)3.33132464
11Abnormality of the corticospinal tract (HP:0002492)3.29717219
12Hypoglycemic seizures (HP:0002173)3.24952422
13Spastic paraparesis (HP:0002313)3.20183054
14Hyperinsulinemic hypoglycemia (HP:0000825)3.14787394
15Intestinal atresia (HP:0011100)3.09765445
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.09568307
17Hypoplasia of the fovea (HP:0007750)3.09568307
18Xanthomatosis (HP:0000991)3.09477324
19Deep venous thrombosis (HP:0002625)3.08323422
20Ependymoma (HP:0002888)3.02448917
21Coronal craniosynostosis (HP:0004440)3.02038853
22Methylmalonic acidemia (HP:0002912)3.01979637
23Hypoglycemic coma (HP:0001325)2.94644020
24Supranuclear gaze palsy (HP:0000605)2.93993400
25Myokymia (HP:0002411)2.86888153
26Neoplasm of the adrenal cortex (HP:0100641)2.84850928
27Neuroendocrine neoplasm (HP:0100634)2.84307304
28Abnormality of the labia minora (HP:0012880)2.83831393
29Hyperlipoproteinemia (HP:0010980)2.83624954
30Cerebral hypomyelination (HP:0006808)2.81903037
31Scanning speech (HP:0002168)2.81633901
32Pheochromocytoma (HP:0002666)2.75908058
33Abnormality of the fovea (HP:0000493)2.75483629
34Anteriorly placed anus (HP:0001545)2.74862796
35Alacrima (HP:0000522)2.69248822
36Akinesia (HP:0002304)2.68679125
37Astrocytoma (HP:0009592)2.68414870
38Abnormality of the astrocytes (HP:0100707)2.68414870
39Sensory axonal neuropathy (HP:0003390)2.66278733
40Peripheral hypomyelination (HP:0007182)2.63285347
41Insidious onset (HP:0003587)2.61012922
42Termporal pattern (HP:0011008)2.61012922
43Congenital stationary night blindness (HP:0007642)2.60921021
44Abnormality of chromosome stability (HP:0003220)2.60843620
45Retinal dysplasia (HP:0007973)2.59943152
46Ketosis (HP:0001946)2.59682601
47Spastic gait (HP:0002064)2.58158561
48Neoplasm of the adrenal gland (HP:0100631)2.58149533
49Abnormality of endocrine pancreas physiology (HP:0012093)2.57442140
50Abnormality of the pancreatic islet cells (HP:0006476)2.57442140
51Pancreatic cysts (HP:0001737)2.55787371
52Glioma (HP:0009733)2.54174152
53Progressive macrocephaly (HP:0004481)2.53887193
54Aplasia/Hypoplasia of the macula (HP:0008059)2.51994251
55Megalencephaly (HP:0001355)2.51345101
56Opisthotonus (HP:0002179)2.45631821
57Delayed CNS myelination (HP:0002188)2.45605130
58Abnormality of vitamin B metabolism (HP:0004340)2.44989402
59Dysmetria (HP:0001310)2.42818490
60Hyperglycemia (HP:0003074)2.42083449
61Pancreatic fibrosis (HP:0100732)2.41980871
62Volvulus (HP:0002580)2.40445197
63Methylmalonic aciduria (HP:0012120)2.39325814
64Hyperventilation (HP:0002883)2.38618413
65Thickened helices (HP:0000391)2.38408505
66Symptomatic seizures (HP:0011145)2.38391189
67Atonic seizures (HP:0010819)2.37439421
68Diminished movement (HP:0002374)2.36235627
69Colon cancer (HP:0003003)2.35709054
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34853268
71Acute encephalopathy (HP:0006846)2.32879577
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.32686859
73Prolonged partial thromboplastin time (HP:0003645)2.31087930
74Paraparesis (HP:0002385)2.30790624
75Generalized myoclonic seizures (HP:0002123)2.29335082
76Acute necrotizing encephalopathy (HP:0006965)2.28862676
77Abnormality of glycolysis (HP:0004366)2.28729145
78Increased serum pyruvate (HP:0003542)2.28729145
79Hyperglycinemia (HP:0002154)2.28248993
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.28221571
81Turricephaly (HP:0000262)2.27787583
82Fat malabsorption (HP:0002630)2.27291012
83Abnormality of serine family amino acid metabolism (HP:0010894)2.27286884
84Abnormality of glycine metabolism (HP:0010895)2.27286884
85Aqueductal stenosis (HP:0002410)2.26891670
86Increased circulating renin level (HP:0000848)2.26392897
87Ketoacidosis (HP:0001993)2.25147014
88Medial flaring of the eyebrow (HP:0010747)2.25069941
89True hermaphroditism (HP:0010459)2.24912283
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.24570809
91Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24557076
92Hamartoma of the eye (HP:0010568)2.23432525
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22491226
94Increased CSF lactate (HP:0002490)2.20130730
95Molar tooth sign on MRI (HP:0002419)2.20113933
96Abnormality of midbrain morphology (HP:0002418)2.20113933
97Tongue fasciculations (HP:0001308)2.19088210
98Meckel diverticulum (HP:0002245)2.17839997
99Hyperammonemia (HP:0001987)2.15641481
100Hypokalemic alkalosis (HP:0001949)2.14510280
101Chromsome breakage (HP:0040012)2.14301588
102Dysostosis multiplex (HP:0000943)2.12987688
103Large for gestational age (HP:0001520)2.12276512
104Patchy hypopigmentation of hair (HP:0011365)2.11252412
105Abnormality of the ileum (HP:0001549)2.11052959
106Rhabdomyosarcoma (HP:0002859)2.10877943
107Progressive inability to walk (HP:0002505)2.10711717
108Cerebral hemorrhage (HP:0001342)2.08925359
109Autoamputation (HP:0001218)2.08230532
110Prominent metopic ridge (HP:0005487)2.08132704
111Delayed myelination (HP:0012448)2.07594704
112Abnormality of the preputium (HP:0100587)2.06187267
113CNS hypomyelination (HP:0003429)2.05939609
114Ankle clonus (HP:0011448)2.03962929
115Abnormality of methionine metabolism (HP:0010901)2.03504726
116Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03401656
117Thyroiditis (HP:0100646)2.02927167
118Adrenal hypoplasia (HP:0000835)2.02881950
119Parakeratosis (HP:0001036)2.02050949
120Nephronophthisis (HP:0000090)2.01296366
121Acanthocytosis (HP:0001927)2.00986815
122Abnormality of the metopic suture (HP:0005556)2.00379651
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.99165200
124Steatorrhea (HP:0002570)1.99146523
125Focal motor seizures (HP:0011153)1.99018443
126Hypokinesia (HP:0002375)1.97303574
127Disproportionate short-trunk short stature (HP:0003521)1.97105148
128Mitochondrial inheritance (HP:0001427)1.97070006
129Premature skin wrinkling (HP:0100678)1.96005299
130Dialeptic seizures (HP:0011146)1.95786531
131Abnormality of the renal cortex (HP:0011035)1.95214214
132Slow saccadic eye movements (HP:0000514)1.93282351
133Hypochromic microcytic anemia (HP:0004840)1.92470968
134Hypomagnesemia (HP:0002917)1.92170874
135Hyperbilirubinemia (HP:0002904)1.91640573
136Epileptic encephalopathy (HP:0200134)1.91409172
137Action tremor (HP:0002345)1.91343898
138Gaze-evoked nystagmus (HP:0000640)1.90796369
139Decreased lacrimation (HP:0000633)1.90726176
140Hypolipoproteinemia (HP:0010981)1.90636789
141Breast carcinoma (HP:0003002)1.88819129
142Leukodystrophy (HP:0002415)1.88809673
143Metabolic alkalosis (HP:0200114)1.88602778
144Clonus (HP:0002169)1.88248859
145White forelock (HP:0002211)1.88187152
146Abolished electroretinogram (ERG) (HP:0000550)1.88073825
147Abnormality of the duodenum (HP:0002246)1.88029630
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87341231
149Absence seizures (HP:0002121)1.86240065
150Diaphragmatic weakness (HP:0009113)1.85173520
151Increased hepatocellular lipid droplets (HP:0006565)1.84832809
152Abnormal auditory evoked potentials (HP:0006958)1.83584648
153Pancreatic islet-cell hyperplasia (HP:0004510)1.82456316
154Hepatic necrosis (HP:0002605)1.79539528
155Hemiparesis (HP:0001269)1.78880069
156Albinism (HP:0001022)1.77758556
157Abnormal lung lobation (HP:0002101)1.76961486
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.76735056
159Postnatal microcephaly (HP:0005484)1.76723686
160Sloping forehead (HP:0000340)1.76331485
161Duodenal stenosis (HP:0100867)1.76229664
162Small intestinal stenosis (HP:0012848)1.76229664
163Abnormal mitochondria in muscle tissue (HP:0008316)1.75538611
164Small hand (HP:0200055)1.75524387
165Type II lissencephaly (HP:0007260)1.75107058
166Progressive neurologic deterioration (HP:0002344)1.75096608
167Abnormality of the renal medulla (HP:0100957)1.74722678
168Renal Fanconi syndrome (HP:0001994)1.74142669
169Abnormality of serum amino acid levels (HP:0003112)1.74095026
170Irritability (HP:0000737)1.74091568
171Onion bulb formation (HP:0003383)1.73519923
172Cutaneous melanoma (HP:0012056)1.73137193
173Gastrointestinal atresia (HP:0002589)1.73053651
174Cholecystitis (HP:0001082)1.72752477
175Abnormal gallbladder physiology (HP:0012438)1.72752477
176Axonal loss (HP:0003447)1.72594515
177Complement deficiency (HP:0004431)1.72411703
178Muscular hypotonia of the trunk (HP:0008936)1.72164054
179Muscle fibrillation (HP:0010546)1.72138642
180Congenital primary aphakia (HP:0007707)1.71177988
181Genital tract atresia (HP:0001827)1.70402230
182Degeneration of anterior horn cells (HP:0002398)1.70148485
183Abnormality of the anterior horn cell (HP:0006802)1.70148485
184Blue irides (HP:0000635)1.70146598
185Dysdiadochokinesis (HP:0002075)1.70078994
186Morphological abnormality of the pyramidal tract (HP:0002062)1.70069112
187Generalized hypopigmentation (HP:0007513)1.69071951
188Conjunctival hamartoma (HP:0100780)1.68829308
189Furrowed tongue (HP:0000221)1.67832374
190Renal cortical cysts (HP:0000803)1.66053899
191Lipid accumulation in hepatocytes (HP:0006561)1.65459658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12754060
2STK394.66330260
3TRIM284.21156225
4OXSR13.67540145
5MAPK153.24632694
6MKNK22.95857290
7ICK2.89065819
8EIF2AK32.77226525
9ACVR1B2.73814256
10DDR22.67463464
11UHMK12.57790281
12BMPR1B2.46554464
13NUAK12.41286059
14WNK42.30928021
15FGFR22.29799162
16MAPKAPK52.27890929
17EIF2AK12.16884380
18PLK32.14638862
19CSNK1G32.13706057
20BUB12.07776984
21CDK192.05666039
22TYRO32.05222856
23CSNK1A1L2.04228133
24FGR1.96833360
25MAP4K21.96028186
26TNIK1.95899996
27PINK11.94107636
28MKNK11.89749051
29BCR1.87374326
30SIK31.81476409
31CSNK1G11.76208417
32CSNK1G21.75377002
33NTRK11.70876158
34TSSK61.68946549
35WEE11.67965266
36EPHA41.59436374
37GRK11.58364249
38BCKDK1.57751480
39LIMK11.57644877
40CAMK2B1.57345853
41MET1.53444090
42NEK11.50198145
43MARK11.48941895
44ZAK1.46948679
45WNK11.46432319
46BRSK21.45273410
47MAP3K61.36439956
48SCYL21.35775802
49PLK41.32749444
50EPHB11.28260558
51MST41.24699112
52ADRBK21.18220145
53TTK1.18178686
54WNK31.14742801
55PAK61.13040689
56STK31.12846281
57PHKG21.10963352
58PHKG11.10963352
59ERBB41.09034310
60FER1.08456395
61CAMK2G1.06916605
62STK38L1.06146214
63CDK141.05808635
64CDK51.05711140
65DYRK1B1.03243823
66PBK1.01495140
67PAK31.01115257
68MINK11.00294960
69DAPK10.98995781
70TESK20.98150077
71MAP3K90.97965664
72PNCK0.97709290
73NTRK30.97081335
74MAPK130.96687618
75INSRR0.96355791
76PLK10.95553493
77SRPK10.93864526
78NTRK20.93824290
79CDK150.92125463
80MAP3K110.92121857
81PDK20.91168123
82MAP3K20.89961719
83CAMK2D0.89946417
84TRPM70.89741489
85CDK180.88716558
86ERBB30.88272265
87SGK4940.88015075
88SGK2230.88015075
89VRK10.84395646
90MATK0.82217093
91CAMK2A0.80468698
92TAF10.80094133
93CDK11A0.79807848
94ROCK20.79684304
95CDC70.79421254
96NLK0.77255220
97CASK0.76332237
98DYRK30.73376768
99EIF2AK20.72946659
100NEK60.71912181
101TGFBR10.71080555
102DYRK20.70005142
103YES10.68315827
104GSK3A0.67929317
105PRPF4B0.67420132
106PKN10.65301914
107PIM20.65240920
108ARAF0.63843368
109MAPK110.60701767
110ATM0.58763467
111PDGFRA0.58666549
112MAP3K40.58372111
113PLK20.58112902
114HIPK20.54298562
115STK160.53660292
116VRK20.52978689
117PIK3CG0.52780475
118RAF10.52552829
119PASK0.52005495
120STK240.51986295
121PTK2B0.51837379
122BRSK10.51331553
123CDK60.50734539
124BMX0.50124800
125PRKCG0.50038780
126ATR0.49621627
127CSK0.48442395
128AKT30.47146154
129ADRBK10.44899578
130PRKCI0.44664196
131ABL20.44206607
132LMTK20.43274895
133MAP2K70.42701233
134FGFR10.42077740
135PRKCQ0.41661122
136KSR20.41112558
137MAPK40.38300560
138PRKCZ0.36868458
139PRKD10.36809494
140BMPR20.36489791
141MAPK100.35225411
142DAPK20.33452930
143PRKCE0.32958891
144PRKAA20.32923791
145CSNK1A10.32488123
146SIK10.30570929
147FYN0.30297102
148IRAK20.29937427
149CSNK1D0.29913851
150CHEK20.29865582
151MAP2K40.28747418
152GRK50.27574150
153EGFR0.27194319
154CDK30.25806364
155CCNB10.25184099
156CSNK2A10.25144819
157CSNK1E0.25043858
158PRKDC0.24577478
159STK40.23856648
160TGFBR20.23720240
161PRKAA10.22004554
162STK100.20907894
163CHEK10.20572721
164MUSK0.20095692

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.67925845
2Fatty acid elongation_Homo sapiens_hsa000623.36461167
3Steroid biosynthesis_Homo sapiens_hsa001003.36048318
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.35313786
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.34415622
6Non-homologous end-joining_Homo sapiens_hsa034503.02160627
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96060961
8Proteasome_Homo sapiens_hsa030502.87939989
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.78366161
10Butanoate metabolism_Homo sapiens_hsa006502.63958496
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48204523
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41664472
13Fatty acid biosynthesis_Homo sapiens_hsa000612.38760604
14Fatty acid metabolism_Homo sapiens_hsa012122.18966109
15Homologous recombination_Homo sapiens_hsa034402.15711819
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01218814
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96384752
18Sulfur metabolism_Homo sapiens_hsa009201.94671928
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92365253
20Fanconi anemia pathway_Homo sapiens_hsa034601.92248529
21Basal transcription factors_Homo sapiens_hsa030221.90479721
22Mismatch repair_Homo sapiens_hsa034301.85413636
23Peroxisome_Homo sapiens_hsa041461.79659403
24Propanoate metabolism_Homo sapiens_hsa006401.78172727
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77751225
26Arginine biosynthesis_Homo sapiens_hsa002201.76143142
27Histidine metabolism_Homo sapiens_hsa003401.74285078
28Arginine and proline metabolism_Homo sapiens_hsa003301.67002102
29RNA degradation_Homo sapiens_hsa030181.66135919
30Folate biosynthesis_Homo sapiens_hsa007901.64318905
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62959682
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61835498
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61735162
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51485566
35RNA polymerase_Homo sapiens_hsa030201.47491308
36One carbon pool by folate_Homo sapiens_hsa006701.42359026
37Protein export_Homo sapiens_hsa030601.42037793
38Vitamin B6 metabolism_Homo sapiens_hsa007501.41624137
39Fatty acid degradation_Homo sapiens_hsa000711.38385622
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31183243
41Tryptophan metabolism_Homo sapiens_hsa003801.28078115
42RNA transport_Homo sapiens_hsa030131.28028580
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27680588
44Phototransduction_Homo sapiens_hsa047441.26060380
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22754674
46GABAergic synapse_Homo sapiens_hsa047271.20069447
47beta-Alanine metabolism_Homo sapiens_hsa004101.18086814
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13491446
49Glutathione metabolism_Homo sapiens_hsa004801.12301247
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11758247
51Bile secretion_Homo sapiens_hsa049761.11125566
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10188348
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07864961
54Regulation of autophagy_Homo sapiens_hsa041401.07559737
55Sulfur relay system_Homo sapiens_hsa041221.06296389
56Ether lipid metabolism_Homo sapiens_hsa005651.06137992
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.06075649
58Complement and coagulation cascades_Homo sapiens_hsa046101.05923646
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.03100302
60Pyruvate metabolism_Homo sapiens_hsa006200.98832117
61Chemical carcinogenesis_Homo sapiens_hsa052040.95596790
62Oocyte meiosis_Homo sapiens_hsa041140.95325337
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94378772
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.92367002
65DNA replication_Homo sapiens_hsa030300.90763824
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90463405
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89031531
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84970066
69PPAR signaling pathway_Homo sapiens_hsa033200.84841580
70Purine metabolism_Homo sapiens_hsa002300.80495175
71Nucleotide excision repair_Homo sapiens_hsa034200.79981451
72Cell cycle_Homo sapiens_hsa041100.79335311
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76650807
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75165746
75Insulin secretion_Homo sapiens_hsa049110.74345265
76Glutamatergic synapse_Homo sapiens_hsa047240.73463900
77p53 signaling pathway_Homo sapiens_hsa041150.70477292
78Linoleic acid metabolism_Homo sapiens_hsa005910.70146099
79Vibrio cholerae infection_Homo sapiens_hsa051100.70080471
80Sphingolipid metabolism_Homo sapiens_hsa006000.69594615
81Nicotine addiction_Homo sapiens_hsa050330.69481533
82Oxidative phosphorylation_Homo sapiens_hsa001900.69160140
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62880535
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61900848
85Metabolic pathways_Homo sapiens_hsa011000.61010616
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60018931
87Pyrimidine metabolism_Homo sapiens_hsa002400.59847359
88Olfactory transduction_Homo sapiens_hsa047400.59585857
89ABC transporters_Homo sapiens_hsa020100.59444471
90Huntingtons disease_Homo sapiens_hsa050160.57900642
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.56963762
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56189581
93Vitamin digestion and absorption_Homo sapiens_hsa049770.55839386
94Morphine addiction_Homo sapiens_hsa050320.55701528
95Tyrosine metabolism_Homo sapiens_hsa003500.55476903
96Retinol metabolism_Homo sapiens_hsa008300.55374910
97Axon guidance_Homo sapiens_hsa043600.52772332
98Selenocompound metabolism_Homo sapiens_hsa004500.52679812
99Circadian rhythm_Homo sapiens_hsa047100.52092017
100Lysosome_Homo sapiens_hsa041420.51911061
101Synaptic vesicle cycle_Homo sapiens_hsa047210.48746923
102Dopaminergic synapse_Homo sapiens_hsa047280.48696035
103Carbon metabolism_Homo sapiens_hsa012000.48061225
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47527938
105Parkinsons disease_Homo sapiens_hsa050120.46870476
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46206754
107Prion diseases_Homo sapiens_hsa050200.45934285
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44599598
109Taste transduction_Homo sapiens_hsa047420.43315500
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42913292
111Long-term depression_Homo sapiens_hsa047300.42429839
112Amphetamine addiction_Homo sapiens_hsa050310.42421914
113Base excision repair_Homo sapiens_hsa034100.41081272
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40333506
115Alzheimers disease_Homo sapiens_hsa050100.40113274
116TGF-beta signaling pathway_Homo sapiens_hsa043500.39921083
117Dorso-ventral axis formation_Homo sapiens_hsa043200.38451875
118Circadian entrainment_Homo sapiens_hsa047130.37686903
119N-Glycan biosynthesis_Homo sapiens_hsa005100.36849732
120Cocaine addiction_Homo sapiens_hsa050300.36646676
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36487070
122Thyroid hormone synthesis_Homo sapiens_hsa049180.36233583
123Phenylalanine metabolism_Homo sapiens_hsa003600.36090641
124Fat digestion and absorption_Homo sapiens_hsa049750.35957937
125Glycerolipid metabolism_Homo sapiens_hsa005610.34998927
126Starch and sucrose metabolism_Homo sapiens_hsa005000.34865084
127Spliceosome_Homo sapiens_hsa030400.34834899
128Lysine degradation_Homo sapiens_hsa003100.33086723
129Serotonergic synapse_Homo sapiens_hsa047260.32892886
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.32272486
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31016430
132mRNA surveillance pathway_Homo sapiens_hsa030150.30725464
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30372028
134Collecting duct acid secretion_Homo sapiens_hsa049660.29637581
135Hippo signaling pathway_Homo sapiens_hsa043900.28601929
136Gap junction_Homo sapiens_hsa045400.26418687
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25927228
138Mineral absorption_Homo sapiens_hsa049780.23991257
139Gastric acid secretion_Homo sapiens_hsa049710.22642490
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.20887234
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20723629
142Caffeine metabolism_Homo sapiens_hsa002320.18827992

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