TMEM35A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.70304318
2nucleobase catabolic process (GO:0046113)6.12998858
3postsynaptic membrane organization (GO:0001941)5.37133530
4neuron cell-cell adhesion (GO:0007158)5.24284050
5synaptic vesicle maturation (GO:0016188)5.05979626
6establishment of mitochondrion localization (GO:0051654)5.04872837
7presynaptic membrane assembly (GO:0097105)5.04765705
8vocalization behavior (GO:0071625)4.74074249
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70224743
10cell migration in hindbrain (GO:0021535)4.69889221
11presynaptic membrane organization (GO:0097090)4.69118471
12gamma-aminobutyric acid transport (GO:0015812)4.59525774
13protein localization to synapse (GO:0035418)4.55166183
14neuron recognition (GO:0008038)4.54128688
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.48307682
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.44648568
17synaptic vesicle exocytosis (GO:0016079)4.37236609
18neurotransmitter-gated ion channel clustering (GO:0072578)4.29898786
19axonal fasciculation (GO:0007413)4.27678265
20glutamate secretion (GO:0014047)4.23569138
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16968126
22regulation of synaptic vesicle exocytosis (GO:2000300)4.11920088
23auditory behavior (GO:0031223)4.08076341
24synaptic transmission, glutamatergic (GO:0035249)4.02168962
25synapse assembly (GO:0007416)4.01032872
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98609026
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94877027
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94491302
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.93818320
30mitochondrion transport along microtubule (GO:0047497)3.93818320
31regulation of synapse structural plasticity (GO:0051823)3.88777842
32behavioral response to nicotine (GO:0035095)3.84348542
33neurotransmitter secretion (GO:0007269)3.79981990
34glutamate receptor signaling pathway (GO:0007215)3.79399569
35dendritic spine morphogenesis (GO:0060997)3.78049622
36positive regulation of synapse assembly (GO:0051965)3.75161796
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71962235
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.66038929
39neuron-neuron synaptic transmission (GO:0007270)3.62771969
40neurofilament cytoskeleton organization (GO:0060052)3.59508161
41regulation of synaptic vesicle transport (GO:1902803)3.58786925
42glycosphingolipid biosynthetic process (GO:0006688)3.44148430
43dendrite morphogenesis (GO:0048813)3.43395152
44regulation of vesicle fusion (GO:0031338)3.41000069
45neuronal action potential propagation (GO:0019227)3.39016302
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.33309758
47positive regulation of mitochondrial fission (GO:0090141)3.33200554
48exploration behavior (GO:0035640)3.27023461
49mechanosensory behavior (GO:0007638)3.26562863
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23356068
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22131406
52calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.20866721
53transmission of nerve impulse (GO:0019226)3.20611129
54synapse organization (GO:0050808)3.18571171
55central nervous system projection neuron axonogenesis (GO:0021952)3.18416894
56cerebral cortex radially oriented cell migration (GO:0021799)3.16657796
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.12218687
58axon extension (GO:0048675)3.10635635
59neuronal ion channel clustering (GO:0045161)3.09278118
60positive regulation of synapse maturation (GO:0090129)3.09106417
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.08169153
62neuromuscular synaptic transmission (GO:0007274)3.07717449
63response to auditory stimulus (GO:0010996)3.07680307
64layer formation in cerebral cortex (GO:0021819)3.06107556
65membrane depolarization during action potential (GO:0086010)3.05438811
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05249834
67adult walking behavior (GO:0007628)3.00342181
68regulation of neurotransmitter levels (GO:0001505)2.97182382
69hippocampus development (GO:0021766)2.96975093
70negative regulation of microtubule polymerization (GO:0031115)2.96217439
71startle response (GO:0001964)2.95800407
72regulation of synapse assembly (GO:0051963)2.95063514
73regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94010911
74regulation of feeding behavior (GO:0060259)2.92712032
75neurotransmitter transport (GO:0006836)2.91384116
76regulation of glutamate receptor signaling pathway (GO:1900449)2.90790535
77positive regulation of membrane potential (GO:0045838)2.90481603
78regulation of postsynaptic membrane potential (GO:0060078)2.88997873
79gamma-aminobutyric acid signaling pathway (GO:0007214)2.87240663
80organelle transport along microtubule (GO:0072384)2.85863695
81regulation of dendritic spine morphogenesis (GO:0061001)2.85200891
82regulation of respiratory system process (GO:0044065)2.84565119
83sequestering of actin monomers (GO:0042989)2.83906872
84positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.81728096
85retinal ganglion cell axon guidance (GO:0031290)2.80988594
86membrane depolarization (GO:0051899)2.79297184
87spinal cord development (GO:0021510)2.79045405
88locomotory exploration behavior (GO:0035641)2.78637990
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78310597
90neuronal action potential (GO:0019228)2.76221050
91limb bud formation (GO:0060174)2.76023270
92positive regulation of dendritic spine development (GO:0060999)2.75747934
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.75711081
94ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.75665155
95substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73931577
96substrate-independent telencephalic tangential migration (GO:0021826)2.73931577
97cerebellar granule cell differentiation (GO:0021707)2.71553042
98synaptic transmission, cholinergic (GO:0007271)2.70812178
99protein localization to cilium (GO:0061512)2.70521914
100regulation of synapse maturation (GO:0090128)2.70009564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45749368
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.51241289
3GBX2_23144817_ChIP-Seq_PC3_Human3.39853660
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.02864970
5REST_21632747_ChIP-Seq_MESCs_Mouse2.80079774
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64761344
7IGF1R_20145208_ChIP-Seq_DFB_Human2.60007885
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54371158
9TAF15_26573619_Chip-Seq_HEK293_Human2.49983534
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.42473034
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40936335
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.36704749
13ZNF274_21170338_ChIP-Seq_K562_Hela2.35161705
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34178911
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.29958139
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28499679
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.16819848
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16535122
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11779784
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07642549
21RNF2_27304074_Chip-Seq_NSC_Mouse2.07135262
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97653972
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96136779
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.95095744
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93543561
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90423630
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89515641
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86693970
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86693970
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85594677
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84829647
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83942053
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79445707
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.75497246
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74415059
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69394655
37DROSHA_22980978_ChIP-Seq_HELA_Human1.66892557
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65017494
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61764000
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57117058
41P300_19829295_ChIP-Seq_ESCs_Human1.56957329
42FUS_26573619_Chip-Seq_HEK293_Human1.53250097
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52498413
44SMAD4_21799915_ChIP-Seq_A2780_Human1.50436003
45AR_21572438_ChIP-Seq_LNCaP_Human1.49953768
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47238395
47VDR_22108803_ChIP-Seq_LS180_Human1.46690036
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45180154
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.41998738
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41066662
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40354552
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38646941
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36961009
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32757137
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28298523
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26072365
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25058538
58AR_25329375_ChIP-Seq_VCAP_Human1.22470446
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22470080
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21868305
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21868305
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.19547737
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19383359
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19226703
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.19134719
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.17210455
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.14301684
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14035740
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13945713
70STAT3_23295773_ChIP-Seq_U87_Human1.13529670
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13392908
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.12395636
73EWS_26573619_Chip-Seq_HEK293_Human1.12303092
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09572828
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08678761
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08182907
77AR_19668381_ChIP-Seq_PC3_Human1.06271307
78TCF4_23295773_ChIP-Seq_U87_Human1.05789915
79JUN_21703547_ChIP-Seq_K562_Human1.02968408
80RUNX2_22187159_ChIP-Seq_PCA_Human1.01741358
81ER_23166858_ChIP-Seq_MCF-7_Human1.01686562
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00153261
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99667010
84TAL1_26923725_Chip-Seq_HPCs_Mouse0.99379957
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99263723
86CBP_20019798_ChIP-Seq_JUKART_Human0.99263723
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97716679
88IRF1_19129219_ChIP-ChIP_H3396_Human0.97411982
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96250918
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96166317
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93035767
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92517908
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.91518855
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90921057
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90747921
96KDM2B_26808549_Chip-Seq_REH_Human0.90227167
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88636635
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87602257
99TP53_22573176_ChIP-Seq_HFKS_Human0.87265954
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.86643737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.30886881
2MP0003880_abnormal_central_pattern4.12924914
3MP0004270_analgesia3.40809856
4MP0005423_abnormal_somatic_nervous3.22466238
5MP0003635_abnormal_synaptic_transmissio3.12767494
6MP0003122_maternal_imprinting2.93886387
7MP0002822_catalepsy2.87262668
8MP0000778_abnormal_nervous_system2.61178363
9MP0002063_abnormal_learning/memory/cond2.57957254
10MP0009745_abnormal_behavioral_response2.56752232
11MP0006276_abnormal_autonomic_nervous2.55905002
12MP0009046_muscle_twitch2.46124555
13MP0001529_abnormal_vocalization2.44034528
14MP0003787_abnormal_imprinting2.39454809
15MP0002064_seizures2.39414486
16MP0002735_abnormal_chemical_nociception2.38567181
17MP0001984_abnormal_olfaction2.34404515
18MP0002272_abnormal_nervous_system2.33010827
19MP0002734_abnormal_mechanical_nocicepti2.29907892
20MP0002572_abnormal_emotion/affect_behav2.27470730
21MP0001968_abnormal_touch/_nociception2.25591523
22MP0001486_abnormal_startle_reflex2.11381607
23MP0003121_genomic_imprinting2.01758186
24MP0002736_abnormal_nociception_after1.99126096
25MP0001188_hyperpigmentation1.91653609
26MP0002733_abnormal_thermal_nociception1.86557155
27MP0001970_abnormal_pain_threshold1.86000730
28MP0002102_abnormal_ear_morphology1.82745842
29MP0004811_abnormal_neuron_physiology1.79850594
30MP0002067_abnormal_sensory_capabilities1.76082173
31MP0000955_abnormal_spinal_cord1.75907243
32MP0002557_abnormal_social/conspecific_i1.73607490
33MP0005499_abnormal_olfactory_system1.72107540
34MP0005394_taste/olfaction_phenotype1.72107540
35MP0002184_abnormal_innervation1.70479564
36MP0005645_abnormal_hypothalamus_physiol1.66910060
37MP0002882_abnormal_neuron_morphology1.63671490
38MP0004742_abnormal_vestibular_system1.59649284
39MP0004142_abnormal_muscle_tone1.58278547
40MP0004924_abnormal_behavior1.53974701
41MP0005386_behavior/neurological_phenoty1.53974701
42MP0004885_abnormal_endolymph1.52463947
43MP0001440_abnormal_grooming_behavior1.48968928
44MP0002638_abnormal_pupillary_reflex1.44984242
45MP0001502_abnormal_circadian_rhythm1.40163178
46MP0008877_abnormal_DNA_methylation1.38619474
47MP0001905_abnormal_dopamine_level1.36376781
48MP0008789_abnormal_olfactory_epithelium1.35663013
49MP0001986_abnormal_taste_sensitivity1.35417562
50MP0002066_abnormal_motor_capabilities/c1.28065766
51MP0001501_abnormal_sleep_pattern1.28020330
52MP0002152_abnormal_brain_morphology1.25439777
53MP0005551_abnormal_eye_electrophysiolog1.24076489
54MP0002752_abnormal_somatic_nervous1.23994550
55MP0008569_lethality_at_weaning1.19310868
56MP0003329_amyloid_beta_deposits1.15789498
57MP0002909_abnormal_adrenal_gland1.15737637
58MP0002751_abnormal_autonomic_nervous1.12608433
59MP0002653_abnormal_ependyma_morphology1.12471847
60MP0000569_abnormal_digit_pigmentation1.10907880
61MP0000631_abnormal_neuroendocrine_gland1.08346340
62MP0000049_abnormal_middle_ear1.07965367
63MP0003890_abnormal_embryonic-extraembry1.05617753
64MP0003879_abnormal_hair_cell1.02665087
65MP0004133_heterotaxia1.01402936
66MP0003633_abnormal_nervous_system0.99083175
67MP0002069_abnormal_eating/drinking_beha0.97987214
68MP0003861_abnormal_nervous_system0.97035172
69MP0002234_abnormal_pharynx_morphology0.96081903
70MP0010386_abnormal_urinary_bladder0.94231025
71MP0000026_abnormal_inner_ear0.94090917
72MP0006292_abnormal_olfactory_placode0.93939095
73MP0002229_neurodegeneration0.92801044
74MP0001485_abnormal_pinna_reflex0.90841410
75MP0003631_nervous_system_phenotype0.90728265
76MP0005253_abnormal_eye_physiology0.87305409
77MP0004145_abnormal_muscle_electrophysio0.86536918
78MP0001963_abnormal_hearing_physiology0.85654465
79MP0005187_abnormal_penis_morphology0.84700919
80MP0003123_paternal_imprinting0.84490803
81MP0003938_abnormal_ear_development0.82528994
82MP0008995_early_reproductive_senescence0.81802806
83MP0001177_atelectasis0.80354729
84MP0006072_abnormal_retinal_apoptosis0.78265762
85MP0001299_abnormal_eye_distance/0.75904004
86MP0005646_abnormal_pituitary_gland0.75811141
87MP0005195_abnormal_posterior_eye0.73582231
88MP0003119_abnormal_digestive_system0.72104585
89MP0004147_increased_porphyrin_level0.69124477
90MP0003385_abnormal_body_wall0.69071496
91MP0001943_abnormal_respiration0.66188527
92MP0003137_abnormal_impulse_conducting0.66143070
93MP0003632_abnormal_nervous_system0.65301578
94MP0002081_perinatal_lethality0.64332644
95MP0002082_postnatal_lethality0.62472568
96MP0010770_preweaning_lethality0.62472568
97MP0004085_abnormal_heartbeat0.61853165
98MP0005084_abnormal_gallbladder_morpholo0.60209175
99MP0010769_abnormal_survival0.59051648
100MP0002837_dystrophic_cardiac_calcinosis0.58888334

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)5.29048634
2Myokymia (HP:0002411)5.18789770
3Focal motor seizures (HP:0011153)4.69147809
4Focal seizures (HP:0007359)4.28206579
5Drooling (HP:0002307)4.23104534
6Polyphagia (HP:0002591)4.20736714
7Excessive salivation (HP:0003781)3.91986011
8Febrile seizures (HP:0002373)3.85937767
9Epileptic encephalopathy (HP:0200134)3.80648613
10Progressive cerebellar ataxia (HP:0002073)3.69992482
11Atonic seizures (HP:0010819)3.49600578
12Lissencephaly (HP:0001339)3.36053292
13Gait imbalance (HP:0002141)3.29924489
14Hyperventilation (HP:0002883)3.28183334
15Broad-based gait (HP:0002136)3.13897200
16Action tremor (HP:0002345)3.06978220
17Abnormal eating behavior (HP:0100738)3.05647668
18Urinary urgency (HP:0000012)3.04695938
19Cortical dysplasia (HP:0002539)3.04622755
20Pachygyria (HP:0001302)3.01974387
21Dialeptic seizures (HP:0011146)2.95032561
22Ankle clonus (HP:0011448)2.89505772
23Abnormality of the labia minora (HP:0012880)2.87892608
24Generalized tonic-clonic seizures (HP:0002069)2.87329850
25Abnormality of the corticospinal tract (HP:0002492)2.86210308
26Agitation (HP:0000713)2.85354535
27Amyotrophic lateral sclerosis (HP:0007354)2.84939515
28Aplasia/Hypoplasia of the brainstem (HP:0007362)2.84008823
29Hypoplasia of the brainstem (HP:0002365)2.84008823
30Spastic tetraplegia (HP:0002510)2.80788528
31Absent speech (HP:0001344)2.79352145
32Failure to thrive in infancy (HP:0001531)2.79066439
33Spastic gait (HP:0002064)2.78682518
34Epileptiform EEG discharges (HP:0011182)2.78183170
35Hypsarrhythmia (HP:0002521)2.75004798
36EEG with generalized epileptiform discharges (HP:0011198)2.74112221
37Medial flaring of the eyebrow (HP:0010747)2.70905586
38Retinal dysplasia (HP:0007973)2.69951077
39Nephrogenic diabetes insipidus (HP:0009806)2.59451093
40Congenital primary aphakia (HP:0007707)2.55532936
41Impaired vibration sensation in the lower limbs (HP:0002166)2.52890350
42Absence seizures (HP:0002121)2.52415157
43Peripheral hypomyelination (HP:0007182)2.50864501
44Mutism (HP:0002300)2.49934488
45Specific learning disability (HP:0001328)2.47964858
46Amblyopia (HP:0000646)2.46348954
47Urinary bladder sphincter dysfunction (HP:0002839)2.43922753
48Inability to walk (HP:0002540)2.34436623
49Genital tract atresia (HP:0001827)2.32687730
50Sleep apnea (HP:0010535)2.31798088
51Fetal akinesia sequence (HP:0001989)2.31099329
52Vaginal atresia (HP:0000148)2.28866275
53Morphological abnormality of the pyramidal tract (HP:0002062)2.27890924
54Poor suck (HP:0002033)2.27230871
55Abnormality of salivation (HP:0100755)2.25424728
56Hypoplasia of the corpus callosum (HP:0002079)2.25345067
57Esotropia (HP:0000565)2.24640774
58Exotropia (HP:0000577)2.24278603
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.23635235
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23635235
61Hemiparesis (HP:0001269)2.22887992
62Ulnar claw (HP:0001178)2.22768096
63Progressive inability to walk (HP:0002505)2.10351794
64Genetic anticipation (HP:0003743)2.09425618
65Type II lissencephaly (HP:0007260)2.07596128
66Status epilepticus (HP:0002133)2.06509026
67Pancreatic fibrosis (HP:0100732)2.06012710
68True hermaphroditism (HP:0010459)2.04237963
69Lower limb muscle weakness (HP:0007340)2.04077341
70Protruding tongue (HP:0010808)2.02371779
71Hip dysplasia (HP:0001385)2.01127971
72Abnormality of midbrain morphology (HP:0002418)2.01090593
73Molar tooth sign on MRI (HP:0002419)2.01090593
74Polymicrogyria (HP:0002126)1.98221251
75Intellectual disability, severe (HP:0010864)1.94838078
76Torticollis (HP:0000473)1.93766494
77Abnormality of the lower motor neuron (HP:0002366)1.92753201
78Abnormal hair whorl (HP:0010721)1.88018612
79Shawl scrotum (HP:0000049)1.87165577
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86827191
81Supranuclear gaze palsy (HP:0000605)1.86718641
82Pancreatic cysts (HP:0001737)1.85681007
83Nephronophthisis (HP:0000090)1.81783449
84Muscular hypotonia of the trunk (HP:0008936)1.81268768
85Thyroid-stimulating hormone excess (HP:0002925)1.80384063
86Narrow forehead (HP:0000341)1.77751018
87Poor coordination (HP:0002370)1.74795402
88Pendular nystagmus (HP:0012043)1.74516857
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.72772562
90Broad alveolar ridges (HP:0000187)1.72221823
91Paraplegia (HP:0010550)1.72168661
92Split foot (HP:0001839)1.71356093
93Generalized myoclonic seizures (HP:0002123)1.71212688
94Optic nerve hypoplasia (HP:0000609)1.68767864
95Hypoventilation (HP:0002791)1.67141072
96Scrotal hypoplasia (HP:0000046)1.65131337
97Focal dystonia (HP:0004373)1.63214135
98Postaxial hand polydactyly (HP:0001162)1.62471848
99Akinesia (HP:0002304)1.62227096
100Tented upper lip vermilion (HP:0010804)1.59119494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.99513544
2CASK4.58182177
3MAP3K43.34278072
4SIK23.32011307
5MAP2K73.31467725
6WNK32.89466447
7MAPK132.71204011
8DYRK22.61787768
9BCR2.39053717
10EPHA42.28561022
11NTRK22.20949806
12MAP4K22.17996827
13MINK12.08830086
14NTRK31.92686780
15TRIM281.88732088
16EPHA31.76007812
17CSNK1G21.57022906
18UHMK11.53593683
19ERBB31.51428135
20MAP2K41.49139444
21PINK11.41033229
22PRKCG1.35910646
23CSNK1G31.33204463
24PAK31.30315241
25CSNK1A1L1.26354753
26PAK61.25413637
27CDK51.24413932
28EPHB21.18729321
29DAPK21.17587059
30PHKG11.13373278
31PHKG21.13373278
32DYRK1A1.12381000
33CDK191.11709563
34CAMKK21.08318761
35CSNK1G11.07507176
36PLK21.07223184
37TNIK1.06471011
38DYRK1B1.02691429
39PKN11.00382431
40SGK2231.00038058
41SGK4941.00038058
42PRKD30.99653600
43DYRK30.94321534
44MAP3K90.93238132
45CAMKK10.91752127
46CAMK2B0.91680518
47CAMK2A0.91561088
48CDK140.87308642
49PRKCE0.81975391
50CDK180.80688098
51LIMK10.79584788
52FRK0.77801970
53CDK150.76301483
54NTRK10.75016687
55ADRBK20.73963979
56CDK11A0.70931933
57TYRO30.70663331
58BCKDK0.68456996
59PRKCZ0.68014154
60KSR10.65465487
61BMPR1B0.63342603
62SGK20.63108810
63CAMK40.61877836
64INSRR0.60948924
65GRK50.56429575
66OXSR10.56261457
67MAP3K60.54716258
68GRK70.54083378
69MARK20.53875870
70WNK40.51287980
71CAMK10.49941966
72GRK10.48817991
73STK110.48420067
74STK380.47290288
75PRKACA0.46859361
76SRPK10.45532861
77PNCK0.45479886
78RPS6KA40.44244319
79CAMK2G0.43352790
80CSNK1D0.42960783
81SIK30.42882155
82PRKAA10.39730693
83TESK10.39499187
84RPS6KA50.39290909
85TAOK10.37904665
86ADRBK10.37765675
87CSNK1E0.37513501
88TAOK30.37277378
89CSNK1A10.35032401
90PRKCH0.34522761
91MAPKAPK50.34350799
92RPS6KA20.32898507
93SGK10.32823010
94RPS6KA30.32016813
95CAMK2D0.29545815
96PRKG10.29479314
97PRKACB0.29287315
98MAPK90.28825869
99MAP3K50.27428383
100STK390.27061827

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.09582251
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25726415
3GABAergic synapse_Homo sapiens_hsa047273.21618813
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92109696
5Morphine addiction_Homo sapiens_hsa050322.74594429
6Glutamatergic synapse_Homo sapiens_hsa047242.58618253
7Circadian entrainment_Homo sapiens_hsa047132.45268316
8Dopaminergic synapse_Homo sapiens_hsa047282.39336204
9Cocaine addiction_Homo sapiens_hsa050302.39231464
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36106529
11Amphetamine addiction_Homo sapiens_hsa050312.11505775
12Phototransduction_Homo sapiens_hsa047442.04325446
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01935451
14Taste transduction_Homo sapiens_hsa047421.99206897
15Axon guidance_Homo sapiens_hsa043601.87594640
16Collecting duct acid secretion_Homo sapiens_hsa049661.84630285
17Cardiac muscle contraction_Homo sapiens_hsa042601.74628343
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74586147
19Cholinergic synapse_Homo sapiens_hsa047251.65992345
20Insulin secretion_Homo sapiens_hsa049111.63268807
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59031305
22Oxidative phosphorylation_Homo sapiens_hsa001901.57821285
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48212824
24Steroid biosynthesis_Homo sapiens_hsa001001.46157382
25Serotonergic synapse_Homo sapiens_hsa047261.41532631
26Parkinsons disease_Homo sapiens_hsa050121.39097445
27Long-term depression_Homo sapiens_hsa047301.28326914
28Long-term potentiation_Homo sapiens_hsa047201.23939851
29Olfactory transduction_Homo sapiens_hsa047401.23158837
30Vibrio cholerae infection_Homo sapiens_hsa051101.22382901
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20855450
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18808529
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13228954
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12324914
35Gap junction_Homo sapiens_hsa045401.12318377
36Gastric acid secretion_Homo sapiens_hsa049711.10801057
37Alzheimers disease_Homo sapiens_hsa050101.06188791
38Oxytocin signaling pathway_Homo sapiens_hsa049211.06017540
39Salivary secretion_Homo sapiens_hsa049701.06002933
40Butanoate metabolism_Homo sapiens_hsa006501.05564125
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00539924
42cAMP signaling pathway_Homo sapiens_hsa040240.96921756
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95929895
44Regulation of autophagy_Homo sapiens_hsa041400.92017941
45Renin secretion_Homo sapiens_hsa049240.91498492
46Calcium signaling pathway_Homo sapiens_hsa040200.89806929
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84344713
48Alcoholism_Homo sapiens_hsa050340.83279683
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80020412
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78705177
51Huntingtons disease_Homo sapiens_hsa050160.78486139
52Type II diabetes mellitus_Homo sapiens_hsa049300.78110874
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76210232
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75562962
55Circadian rhythm_Homo sapiens_hsa047100.72882658
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69912714
57Protein export_Homo sapiens_hsa030600.66739208
58Ether lipid metabolism_Homo sapiens_hsa005650.66656028
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65520152
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65465982
61Oocyte meiosis_Homo sapiens_hsa041140.63415228
62Ras signaling pathway_Homo sapiens_hsa040140.63069085
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62805035
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60706776
65Basal transcription factors_Homo sapiens_hsa030220.57313407
66Dilated cardiomyopathy_Homo sapiens_hsa054140.55535658
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54264911
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53775045
69Melanogenesis_Homo sapiens_hsa049160.51941002
70Hedgehog signaling pathway_Homo sapiens_hsa043400.50056423
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49912467
72Peroxisome_Homo sapiens_hsa041460.49786829
73Linoleic acid metabolism_Homo sapiens_hsa005910.48934519
74Hippo signaling pathway_Homo sapiens_hsa043900.44969833
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44715964
76GnRH signaling pathway_Homo sapiens_hsa049120.42568082
77Estrogen signaling pathway_Homo sapiens_hsa049150.40982510
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40175322
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40081832
80MAPK signaling pathway_Homo sapiens_hsa040100.39207216
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38875937
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37678307
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37224364
84ErbB signaling pathway_Homo sapiens_hsa040120.36961102
85Rap1 signaling pathway_Homo sapiens_hsa040150.36224551
86AMPK signaling pathway_Homo sapiens_hsa041520.35438907
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34445893
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32288926
89Phagosome_Homo sapiens_hsa041450.31847283
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30506858
91Arginine and proline metabolism_Homo sapiens_hsa003300.30028226
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29123758
93Ovarian steroidogenesis_Homo sapiens_hsa049130.28985582
94Wnt signaling pathway_Homo sapiens_hsa043100.28426979
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.26835013
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25602831
97Bile secretion_Homo sapiens_hsa049760.22586046
98Dorso-ventral axis formation_Homo sapiens_hsa043200.22570638
99Pancreatic secretion_Homo sapiens_hsa049720.20881747
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.18671067

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