TMEM35B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.33783653
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15051879
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.59071718
4ATP synthesis coupled proton transport (GO:0015986)4.59071718
5proteasome assembly (GO:0043248)4.28092898
6response to interferon-beta (GO:0035456)4.21756455
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19287621
8cytidine metabolic process (GO:0046087)3.96620446
9cytidine catabolic process (GO:0006216)3.96620446
10cytidine deamination (GO:0009972)3.96620446
11platelet dense granule organization (GO:0060155)3.90340343
12respiratory electron transport chain (GO:0022904)3.87147013
13protein complex biogenesis (GO:0070271)3.83974877
14electron transport chain (GO:0022900)3.83345470
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.78976409
16cytochrome complex assembly (GO:0017004)3.72216046
17respiratory chain complex IV assembly (GO:0008535)3.72078264
18mitochondrial respiratory chain complex assembly (GO:0033108)3.53099320
19regulation of cellular amino acid metabolic process (GO:0006521)3.42404853
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41868795
21chaperone-mediated protein transport (GO:0072321)3.31700872
22protein neddylation (GO:0045116)3.30793391
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.24775181
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24045725
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.19696185
26NADH dehydrogenase complex assembly (GO:0010257)3.19696185
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19696185
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17236039
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15828446
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12235851
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12235851
32water-soluble vitamin biosynthetic process (GO:0042364)3.10500784
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08420433
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07718364
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07718364
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07718364
37antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07176469
38cellular response to zinc ion (GO:0071294)3.04399097
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03868701
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03868701
41rRNA modification (GO:0000154)3.02936175
42positive regulation of prostaglandin secretion (GO:0032308)2.90595508
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89822660
44negative regulation of ligase activity (GO:0051352)2.89822660
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88003519
46signal transduction involved in DNA damage checkpoint (GO:0072422)2.86278487
47signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86278487
48regulation of mitochondrial translation (GO:0070129)2.85941948
49signal peptide processing (GO:0006465)2.84250600
50termination of RNA polymerase III transcription (GO:0006386)2.80031288
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.80031288
52cellular response to interferon-beta (GO:0035458)2.79969400
53xenobiotic catabolic process (GO:0042178)2.79780644
54signal transduction involved in cell cycle checkpoint (GO:0072395)2.77104772
55hydrogen ion transmembrane transport (GO:1902600)2.77000030
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74735060
57immunoglobulin mediated immune response (GO:0016064)2.70721954
58antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68893864
59proton transport (GO:0015992)2.66622293
60deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65958359
61hydrogen transport (GO:0006818)2.61809831
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61681135
63mannosylation (GO:0097502)2.61558004
64preassembly of GPI anchor in ER membrane (GO:0016254)2.60317876
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57431425
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57120026
67positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.55642738
68B cell mediated immunity (GO:0019724)2.53637850
69regulation of interleukin-8 secretion (GO:2000482)2.52747332
70pseudouridine synthesis (GO:0001522)2.52528016
71GPI anchor biosynthetic process (GO:0006506)2.51849332
72rRNA methylation (GO:0031167)2.50730122
73ATP biosynthetic process (GO:0006754)2.49826708
74positive regulation of ligase activity (GO:0051351)2.49025770
75negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.48419785
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47304426
77eosinophil chemotaxis (GO:0048245)2.46841867
78cullin deneddylation (GO:0010388)2.44717379
79C-terminal protein lipidation (GO:0006501)2.43894968
80negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.42941822
81regulation of cellular amine metabolic process (GO:0033238)2.42938627
82protein deneddylation (GO:0000338)2.42477161
83purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42292025
84protein-cofactor linkage (GO:0018065)2.39166270
85regulation of regulatory T cell differentiation (GO:0045589)2.39029929
86oxidative phosphorylation (GO:0006119)2.39017381
87purine nucleotide salvage (GO:0032261)2.38202707
88ribosomal small subunit assembly (GO:0000028)2.37463655
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.36353373
90positive regulation of calcium ion import (GO:0090280)2.35087639
91DNA catabolic process, exonucleolytic (GO:0000738)2.31593773
92positive regulation of cell cycle arrest (GO:0071158)2.31448250
93positive regulation of monocyte chemotaxis (GO:0090026)2.31198002
94positive regulation of interleukin-8 secretion (GO:2000484)2.30479727
95GPI anchor metabolic process (GO:0006505)2.29904355
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29859358
97negative regulation of viral genome replication (GO:0045071)2.29838638
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.27890640
99regulation of prostaglandin secretion (GO:0032306)2.27156420
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.26728280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62972625
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.22742782
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.01244810
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.57097427
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52671887
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11219892
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98187922
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.81455292
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67739057
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62235649
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57231834
12ELK1_19687146_ChIP-ChIP_HELA_Human2.54055178
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47558121
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46235743
15VDR_23849224_ChIP-Seq_CD4+_Human2.46223378
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.43030845
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34179338
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29102707
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21086700
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.14102005
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12358097
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.11862788
23FOXP3_21729870_ChIP-Seq_TREG_Human2.06671528
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.96398266
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86253913
26VDR_22108803_ChIP-Seq_LS180_Human1.85828356
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77881384
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72277166
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69060515
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63409846
31ZNF274_21170338_ChIP-Seq_K562_Hela1.62861523
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57346951
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56301032
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50138465
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47798526
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45760442
37GATA3_26560356_Chip-Seq_TH2_Human1.41984779
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40591356
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40549750
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.40398785
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39946318
42AR_20517297_ChIP-Seq_VCAP_Human1.34895910
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34343112
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32828436
45NANOG_19829295_ChIP-Seq_ESCs_Human1.31210851
46SOX2_19829295_ChIP-Seq_ESCs_Human1.31210851
47MYC_18940864_ChIP-ChIP_HL60_Human1.29217525
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.28167912
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28167912
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.26254893
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22643782
52TP53_22573176_ChIP-Seq_HFKS_Human1.21918793
53SPI1_23547873_ChIP-Seq_NB4_Human1.21613097
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21592935
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21577443
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21004330
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.16446281
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16432030
59EWS_26573619_Chip-Seq_HEK293_Human1.15459291
60MYB_26560356_Chip-Seq_TH2_Human1.13622893
61DCP1A_22483619_ChIP-Seq_HELA_Human1.12736067
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12239953
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09547420
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09433090
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.08741527
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07852175
67HTT_18923047_ChIP-ChIP_STHdh_Human1.07749446
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07309768
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01702561
70P300_19829295_ChIP-Seq_ESCs_Human0.99808150
71MYC_18555785_ChIP-Seq_MESCs_Mouse0.98066934
72ERG_20517297_ChIP-Seq_VCAP_Human0.97852180
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94464968
74FOXH1_21741376_ChIP-Seq_EPCs_Human0.94055140
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92950618
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92373858
77ER_23166858_ChIP-Seq_MCF-7_Human0.91452939
78BCAT_22108803_ChIP-Seq_LS180_Human0.91390440
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91360570
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91244335
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91207537
82IRF8_27001747_Chip-Seq_BMDM_Mouse0.91199660
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.90434039
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.88983382
85STAT1_20625510_ChIP-Seq_HELA_Human0.88430100
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88098095
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.86797614
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86514319
89MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86326874
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86193330
91NANOG_20526341_ChIP-Seq_ESCs_Human0.85970823
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.84747849
93RBPJ_21746931_ChIP-Seq_IB4_Human0.83260764
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83028085
95PHF8_20622853_ChIP-Seq_HELA_Human0.82578406
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82554003
97CDX2_22108803_ChIP-Seq_LS180_Human0.82436412
98ELF5_23300383_ChIP-Seq_T47D_Human0.82435170
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82373120
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82279662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.78872909
2MP0003195_calcinosis3.34965078
3MP0005671_abnormal_response_to2.97902484
4MP0001835_abnormal_antigen_presentation2.88595815
5MP0006054_spinal_hemorrhage2.71383364
6MP0002148_abnormal_hypersensitivity_rea2.69824156
7MP0009785_altered_susceptibility_to2.62324072
8MP0005084_abnormal_gallbladder_morpholo2.37244170
9MP0003186_abnormal_redox_activity2.34276344
10MP0006082_CNS_inflammation2.27949273
11MP0003724_increased_susceptibility_to2.15786524
12MP0002277_abnormal_respiratory_mucosa2.01188430
13MP0006036_abnormal_mitochondrial_physio1.97425586
14MP0006072_abnormal_retinal_apoptosis1.89992243
15MP0002139_abnormal_hepatobiliary_system1.89852721
16MP0005000_abnormal_immune_tolerance1.89621448
17MP0002163_abnormal_gland_morphology1.86574402
18MP0001853_heart_inflammation1.83371688
19MP0002837_dystrophic_cardiac_calcinosis1.81568480
20MP0001790_abnormal_immune_system1.74967630
21MP0005387_immune_system_phenotype1.74967630
22MP0003011_delayed_dark_adaptation1.74423925
23MP0002138_abnormal_hepatobiliary_system1.71554505
24MP0010386_abnormal_urinary_bladder1.70999726
25MP0005379_endocrine/exocrine_gland_phen1.68027653
26MP0002452_abnormal_antigen_presenting1.67696131
27MP0002723_abnormal_immune_serum1.65285470
28MP0002254_reproductive_system_inflammat1.63494338
29MP0001800_abnormal_humoral_immune1.63093624
30MP0005025_abnormal_response_to1.62115451
31MP0003786_premature_aging1.56759966
32MP0009333_abnormal_splenocyte_physiolog1.56724926
33MP0002132_abnormal_respiratory_system1.56133803
34MP0008875_abnormal_xenobiotic_pharmacok1.55249473
35MP0002166_altered_tumor_susceptibility1.53866974
36MP0002419_abnormal_innate_immunity1.53191660
37MP0000685_abnormal_immune_system1.51565743
38MP0001845_abnormal_inflammatory_respons1.51497911
39MP0000372_irregular_coat_pigmentation1.51001820
40MP0002420_abnormal_adaptive_immunity1.48567954
41MP0001819_abnormal_immune_cell1.48409566
42MP0002006_tumorigenesis1.43702120
43MP0001542_abnormal_bone_strength1.40993113
44MP0003252_abnormal_bile_duct1.37106249
45MP0008469_abnormal_protein_level1.36351515
46MP0005332_abnormal_amino_acid1.34501955
47MP0002405_respiratory_system_inflammati1.34204979
48MP0004147_increased_porphyrin_level1.33950206
49MP0002876_abnormal_thyroid_physiology1.29148193
50MP0009764_decreased_sensitivity_to1.28951999
51MP0005367_renal/urinary_system_phenotyp1.28389299
52MP0000516_abnormal_urinary_system1.28389299
53MP0008058_abnormal_DNA_repair1.28218375
54MP0008872_abnormal_physiological_respon1.25554926
55MP0009697_abnormal_copulation1.20804529
56MP0003763_abnormal_thymus_physiology1.17241019
57MP0000343_altered_response_to1.15748959
58MP0001533_abnormal_skeleton_physiology1.15252825
59MP0005410_abnormal_fertilization1.14838446
60MP0005464_abnormal_platelet_physiology1.11185795
61MP0003436_decreased_susceptibility_to1.10916991
62MP0005365_abnormal_bile_salt1.10755912
63MP0005085_abnormal_gallbladder_physiolo1.10576190
64MP0003075_altered_response_to1.10504867
65MP0000689_abnormal_spleen_morphology1.09009860
66MP0002933_joint_inflammation1.08235024
67MP0005636_abnormal_mineral_homeostasis1.07056896
68MP0005645_abnormal_hypothalamus_physiol1.07016402
69MP0003950_abnormal_plasma_membrane1.06628029
70MP0003718_maternal_effect1.05186612
71MP0005164_abnormal_response_to1.05079433
72MP0005075_abnormal_melanosome_morpholog1.03656743
73MP0002693_abnormal_pancreas_physiology1.02249608
74MP0000716_abnormal_immune_system1.01933589
75MP0005397_hematopoietic_system_phenotyp1.01731998
76MP0001545_abnormal_hematopoietic_system1.01731998
77MP0005165_increased_susceptibility_to1.00236261
78MP0005551_abnormal_eye_electrophysiolog0.99409218
79MP0004019_abnormal_vitamin_homeostasis0.98682829
80MP0010155_abnormal_intestine_physiology0.93308917
81MP0001764_abnormal_homeostasis0.92337872
82MP0002398_abnormal_bone_marrow0.90321614
83MP0005166_decreased_susceptibility_to0.88955418
84MP0005253_abnormal_eye_physiology0.87967938
85MP0001986_abnormal_taste_sensitivity0.86517640
86MP0009643_abnormal_urine_homeostasis0.83319339
87MP0002429_abnormal_blood_cell0.82994672
88MP0001756_abnormal_urination0.82444189
89MP0001919_abnormal_reproductive_system0.79924046
90MP0001881_abnormal_mammary_gland0.79644388
91MP0005389_reproductive_system_phenotype0.79418945
92MP0004883_abnormal_blood_vessel0.79378091
93MP0001905_abnormal_dopamine_level0.78949634
94MP0010329_abnormal_lipoprotein_level0.78542499
95MP0009763_increased_sensitivity_to0.78258184
96MP0002722_abnormal_immune_system0.76746465
97MP0002295_abnormal_pulmonary_circulatio0.75994856
98MP0003283_abnormal_digestive_organ0.75236153
99MP0005220_abnormal_exocrine_pancreas0.74847847
100MP0008873_increased_physiological_sensi0.73043765

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32996721
2Mitochondrial inheritance (HP:0001427)4.27845899
3Hepatocellular necrosis (HP:0001404)3.96278705
4Progressive macrocephaly (HP:0004481)3.88999453
5Increased CSF lactate (HP:0002490)3.83974420
6Abnormal mitochondria in muscle tissue (HP:0008316)3.78206409
7Acute encephalopathy (HP:0006846)3.74424984
8Hepatic necrosis (HP:0002605)3.73104597
9Increased hepatocellular lipid droplets (HP:0006565)3.64615163
10Lipid accumulation in hepatocytes (HP:0006561)3.52148916
11Renal Fanconi syndrome (HP:0001994)3.44436920
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25548213
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25548213
14Aplastic anemia (HP:0001915)3.21880430
153-Methylglutaconic aciduria (HP:0003535)3.15340512
16Methylmalonic acidemia (HP:0002912)3.09149845
17Exertional dyspnea (HP:0002875)2.99961917
18Congenital, generalized hypertrichosis (HP:0004540)2.99881262
19Methylmalonic aciduria (HP:0012120)2.89955768
20Elevated erythrocyte sedimentation rate (HP:0003565)2.87534682
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86936025
22Type I transferrin isoform profile (HP:0003642)2.85474572
23Cerebral edema (HP:0002181)2.81890438
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80460074
25Respiratory failure (HP:0002878)2.68457271
26Increased serum lactate (HP:0002151)2.66099512
27Stomatitis (HP:0010280)2.61508700
28Lactic acidosis (HP:0003128)2.57742365
29Increased intramyocellular lipid droplets (HP:0012240)2.57698589
30Hypothermia (HP:0002045)2.53156365
31Abnormal protein glycosylation (HP:0012346)2.47935858
32Abnormal glycosylation (HP:0012345)2.47935858
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47935858
34Abnormal protein N-linked glycosylation (HP:0012347)2.47935858
35Abnormality of renal resorption (HP:0011038)2.45552386
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45377213
37Glycosuria (HP:0003076)2.32984822
38Abnormality of urine glucose concentration (HP:0011016)2.32984822
39Abnormality of vitamin B metabolism (HP:0004340)2.32524112
40IgG deficiency (HP:0004315)2.32233244
41Abnormality of the prostate (HP:0008775)2.31839691
42Generalized aminoaciduria (HP:0002909)2.27619362
43Lethargy (HP:0001254)2.26951890
44Increased muscle lipid content (HP:0009058)2.25304590
45Hypoproteinemia (HP:0003075)2.22449529
46Abolished electroretinogram (ERG) (HP:0000550)2.19100709
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18338360
48Dicarboxylic aciduria (HP:0003215)2.18338360
49Pancreatic cysts (HP:0001737)2.17765325
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10476747
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07953798
52Optic disc pallor (HP:0000543)2.06756364
53Pancreatic fibrosis (HP:0100732)2.04847865
54Exercise intolerance (HP:0003546)2.04443678
55Abnormality of T cell number (HP:0011839)2.03991451
56Vacuolated lymphocytes (HP:0001922)2.02377190
57Thyroiditis (HP:0100646)2.01328844
58Respiratory difficulties (HP:0002880)2.01002198
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.00117723
60Abnormality of methionine metabolism (HP:0010901)1.98954120
61Petechiae (HP:0000967)1.98804330
62Pulmonary fibrosis (HP:0002206)1.97507898
63Pancytopenia (HP:0001876)1.97389712
64Oral leukoplakia (HP:0002745)1.96553127
65T lymphocytopenia (HP:0005403)1.93004907
66Abnormal albumin level (HP:0012116)1.91537245
67Hypoalbuminemia (HP:0003073)1.91537245
68Congenital stationary night blindness (HP:0007642)1.91196981
69Reduced antithrombin III activity (HP:0001976)1.90737707
70Hyperinsulinemic hypoglycemia (HP:0000825)1.88866101
71Medial flaring of the eyebrow (HP:0010747)1.87789549
72Azoospermia (HP:0000027)1.87350999
73Nausea (HP:0002018)1.87211211
74Molar tooth sign on MRI (HP:0002419)1.85560354
75Abnormality of midbrain morphology (HP:0002418)1.85560354
76CNS demyelination (HP:0007305)1.84839946
77Abnormal number of erythroid precursors (HP:0012131)1.84237243
78Abnormal rod and cone electroretinograms (HP:0008323)1.84141850
79True hermaphroditism (HP:0010459)1.81769000
80Large for gestational age (HP:0001520)1.81636805
81Increased IgM level (HP:0003496)1.80555516
82Neutropenia (HP:0001875)1.79992781
83Abnormality of T cells (HP:0002843)1.79710587
84Abnormality of B cell number (HP:0010975)1.79046305
85Hypoglycemic coma (HP:0001325)1.76431546
86Abnormal spermatogenesis (HP:0008669)1.72494494
87Palpitations (HP:0001962)1.71957368
88Hypoglycemic seizures (HP:0002173)1.71276714
89Abnormality of macrophages (HP:0004311)1.71053668
90Abnormality of T cell physiology (HP:0011840)1.70283419
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.68772992
92Hyperalaninemia (HP:0003348)1.68243749
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68243749
94Abnormality of alanine metabolism (HP:0010916)1.68243749
95Abnormality of the anterior horn cell (HP:0006802)1.68191811
96Degeneration of anterior horn cells (HP:0002398)1.68191811
97Severe combined immunodeficiency (HP:0004430)1.67788487
98Abnormality of transition element cation homeostasis (HP:0011030)1.67573714
99Aplasia/hypoplasia of the uterus (HP:0008684)1.67494240
100Abnormality of the pons (HP:0007361)1.67479170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.76607581
2VRK23.97677763
3TXK3.12076845
4MAP3K122.75428017
5FRK2.71742569
6ZAK2.48526062
7NUAK12.36496266
8TAOK32.25824128
9BCKDK2.01412305
10VRK12.01230855
11KDR2.00013677
12TESK21.89630244
13GRK11.89119677
14TLK11.88587462
15STK161.81609193
16ADRBK21.81186347
17EIF2AK31.79998586
18BMPR1B1.66254755
19MYLK1.62671646
20GRK71.47448638
21MAP4K21.46295705
22KIT1.43490816
23NME21.38344946
24TAF11.37096986
25ACVR1B1.35188136
26IKBKB1.28396120
27MAP4K11.23769031
28STK101.16503481
29TYK21.15059222
30IKBKE1.12229877
31OXSR11.09652320
32TEC1.07619504
33BMPR21.07405415
34BUB11.07392400
35INSRR1.05731585
36PBK1.04446007
37WNK31.01547360
38PDK20.98908357
39DAPK10.98704330
40TGFBR20.95480922
41PLK30.91661563
42GRK60.86062166
43TBK10.85816142
44ABL20.81127258
45NLK0.80537362
46LIMK10.80417093
47TESK10.78511797
48ITK0.78345509
49STK390.77344321
50GRK50.77053813
51MUSK0.76008087
52CSNK1G10.74536591
53LMTK20.73384462
54ADRBK10.73145630
55TRIM280.72821233
56NME10.72207506
57EIF2AK10.71178492
58MAPKAPK30.70115589
59PRKCQ0.69717693
60EIF2AK20.69089157
61LYN0.68811639
62SYK0.67810561
63TIE10.67746986
64PINK10.61750748
65CSNK1G30.60963851
66FES0.60008691
67MAPK150.57069332
68CSF1R0.56622250
69MARK30.54807110
70TNK20.53594894
71SRPK10.53012051
72PRKCE0.51351437
73LCK0.50549065
74TNIK0.49941507
75MAP3K140.48209818
76BRSK20.47318894
77JAK30.46838006
78ERBB30.46244829
79JAK10.45968863
80FLT30.45373822
81CSNK1G20.44585622
82TRPM70.44126331
83MAP2K60.44062491
84TGFBR10.42349690
85IRAK40.42105018
86PASK0.42018931
87ILK0.41456090
88DAPK30.40344762
89CSNK2A10.39079849
90STK30.36957516
91RPS6KA50.36629464
92PRKCI0.36529323
93PTK2B0.36498711
94MATK0.36240083
95ZAP700.36147437
96PIM10.36089689
97PLK20.35878247
98SCYL20.35725171
99STK40.35326815
100CSNK2A20.35320841

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.25743229
2Oxidative phosphorylation_Homo sapiens_hsa001903.65607217
3Protein export_Homo sapiens_hsa030603.17920873
4Parkinsons disease_Homo sapiens_hsa050122.92173591
5Ribosome_Homo sapiens_hsa030102.33287148
6Asthma_Homo sapiens_hsa053102.22538005
7Graft-versus-host disease_Homo sapiens_hsa053322.19836411
8Allograft rejection_Homo sapiens_hsa053302.18420967
9Autoimmune thyroid disease_Homo sapiens_hsa053202.12317421
10Type I diabetes mellitus_Homo sapiens_hsa049402.08415951
11RNA polymerase_Homo sapiens_hsa030202.03700550
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90642051
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.88004047
14Alzheimers disease_Homo sapiens_hsa050101.86852756
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83598621
16Huntingtons disease_Homo sapiens_hsa050161.82746563
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82454388
18Rheumatoid arthritis_Homo sapiens_hsa053231.77504300
19Primary immunodeficiency_Homo sapiens_hsa053401.71654572
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.69120389
21Homologous recombination_Homo sapiens_hsa034401.65881046
22Antigen processing and presentation_Homo sapiens_hsa046121.65748520
23Folate biosynthesis_Homo sapiens_hsa007901.57333121
24Sulfur metabolism_Homo sapiens_hsa009201.52835755
25Fatty acid elongation_Homo sapiens_hsa000621.46184741
26Mismatch repair_Homo sapiens_hsa034301.44115794
27Glutathione metabolism_Homo sapiens_hsa004801.40169943
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39575611
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36921809
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30853130
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23986741
32Propanoate metabolism_Homo sapiens_hsa006401.19132204
33Hematopoietic cell lineage_Homo sapiens_hsa046401.18484492
34Staphylococcus aureus infection_Homo sapiens_hsa051501.18445072
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.11284788
36Peroxisome_Homo sapiens_hsa041461.09162097
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08589382
38Collecting duct acid secretion_Homo sapiens_hsa049661.08406021
39Pyrimidine metabolism_Homo sapiens_hsa002401.08277901
40DNA replication_Homo sapiens_hsa030301.07086721
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01926356
42Chemical carcinogenesis_Homo sapiens_hsa052041.01683960
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97185711
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96906275
45Basal transcription factors_Homo sapiens_hsa030220.94068338
46Nucleotide excision repair_Homo sapiens_hsa034200.92971466
47Fanconi anemia pathway_Homo sapiens_hsa034600.92172757
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91962569
49Caffeine metabolism_Homo sapiens_hsa002320.91387589
50RNA degradation_Homo sapiens_hsa030180.91129269
51Tryptophan metabolism_Homo sapiens_hsa003800.89288511
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89073505
53Purine metabolism_Homo sapiens_hsa002300.88653278
54One carbon pool by folate_Homo sapiens_hsa006700.88549114
55Phototransduction_Homo sapiens_hsa047440.87327018
56Cardiac muscle contraction_Homo sapiens_hsa042600.82783769
57Nitrogen metabolism_Homo sapiens_hsa009100.79893732
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77086814
59Arachidonic acid metabolism_Homo sapiens_hsa005900.76515505
60Butanoate metabolism_Homo sapiens_hsa006500.75506487
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73635759
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.72049267
63Base excision repair_Homo sapiens_hsa034100.71377907
64Linoleic acid metabolism_Homo sapiens_hsa005910.70958007
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70425206
66Legionellosis_Homo sapiens_hsa051340.70018821
67Leishmaniasis_Homo sapiens_hsa051400.68433203
68Mineral absorption_Homo sapiens_hsa049780.67903623
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67391627
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.66493321
71Selenocompound metabolism_Homo sapiens_hsa004500.65908430
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65896500
73Metabolic pathways_Homo sapiens_hsa011000.65495862
74Non-homologous end-joining_Homo sapiens_hsa034500.64513079
75Retinol metabolism_Homo sapiens_hsa008300.63893268
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62875991
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61615575
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59103908
79Fatty acid degradation_Homo sapiens_hsa000710.58038706
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57095292
81Viral myocarditis_Homo sapiens_hsa054160.55899217
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55779178
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.54099199
84Herpes simplex infection_Homo sapiens_hsa051680.53218043
85Regulation of autophagy_Homo sapiens_hsa041400.49655393
86N-Glycan biosynthesis_Homo sapiens_hsa005100.47477076
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47115492
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46104301
89Lysosome_Homo sapiens_hsa041420.45596153
90Malaria_Homo sapiens_hsa051440.45567274
91Vitamin digestion and absorption_Homo sapiens_hsa049770.44842262
92Complement and coagulation cascades_Homo sapiens_hsa046100.44158835
93Ether lipid metabolism_Homo sapiens_hsa005650.43266036
94Pertussis_Homo sapiens_hsa051330.43160103
95Pyruvate metabolism_Homo sapiens_hsa006200.39558569
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.37963695
97African trypanosomiasis_Homo sapiens_hsa051430.37883533
98Spliceosome_Homo sapiens_hsa030400.37844601
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.36749129
100Sulfur relay system_Homo sapiens_hsa041220.36699785

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