ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.06285104
2	L-phenylalanine catabolic process (GO:0006559)	5.91207720
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.91207720
4	L-phenylalanine metabolic process (GO:0006558)	5.81268923
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.81268923
6	aromatic amino acid family catabolic process (GO:0009074)	5.59469617
7	indole-containing compound catabolic process (GO:0042436)	5.30861902
8	indolalkylamine catabolic process (GO:0046218)	5.30861902
9	tryptophan catabolic process (GO:0006569)	5.30861902
10	high-density lipoprotein particle remodeling (GO:0034375)	5.17223717
11	glyoxylate metabolic process (GO:0046487)	5.06732895
12	protein carboxylation (GO:0018214)	5.04171242
13	peptidyl-glutamic acid carboxylation (GO:0017187)	5.04171242
14	epoxygenase P450 pathway (GO:0019373)	5.02452665
15	kynurenine metabolic process (GO:0070189)	5.01918167
16	regulation of cholesterol esterification (GO:0010872)	4.97730700
17	tryptophan metabolic process (GO:0006568)	4.95416745
18	reverse cholesterol transport (GO:0043691)	4.78429459
19	NADH metabolic process (GO:0006734)	4.78310936
20	angiotensin maturation (GO:0002003)	4.74594140
21	phospholipid efflux (GO:0033700)	4.74466002
22	ethanol oxidation (GO:0006069)	4.73845471
23	negative regulation of fibrinolysis (GO:0051918)	4.70685710
24	urea cycle (GO:0000050)	4.67116636
25	urea metabolic process (GO:0019627)	4.67116636
26	bile acid biosynthetic process (GO:0006699)	4.66328402
27	cysteine metabolic process (GO:0006534)	4.65619542
28	intestinal absorption (GO:0050892)	4.65385312
29	complement activation, alternative pathway (GO:0006957)	4.64076167
30	regulation of protein activation cascade (GO:2000257)	4.59362553
31	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.54132724
32	serine family amino acid catabolic process (GO:0009071)	4.53882489
33	plasma lipoprotein particle remodeling (GO:0034369)	4.53644758
34	protein-lipid complex remodeling (GO:0034368)	4.53644758
35	macromolecular complex remodeling (GO:0034367)	4.53644758
36	sulfur amino acid catabolic process (GO:0000098)	4.51209589
37	low-density lipoprotein particle clearance (GO:0034383)	4.44837988
38	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.42245951
39	regulation of fibrinolysis (GO:0051917)	4.41997230
40	diacylglycerol metabolic process (GO:0046339)	4.41031034
41	regulation of triglyceride catabolic process (GO:0010896)	4.40559108
42	plasma lipoprotein particle clearance (GO:0034381)	4.39422234
43	transcytosis (GO:0045056)	4.38949904
44	alpha-linolenic acid metabolic process (GO:0036109)	4.36726947
45	regulation of complement activation (GO:0030449)	4.35007609
46	nitrogen cycle metabolic process (GO:0071941)	4.32208724
47	aldehyde catabolic process (GO:0046185)	4.18881387
48	cholesterol efflux (GO:0033344)	4.14699415
49	aromatic amino acid family metabolic process (GO:0009072)	4.10208143
50	negative regulation of cholesterol transport (GO:0032375)	4.10065581
51	negative regulation of sterol transport (GO:0032372)	4.10065581
52	amino-acid betaine metabolic process (GO:0006577)	4.10000168
53	lysine metabolic process (GO:0006553)	4.05455396
54	lysine catabolic process (GO:0006554)	4.05455396
55	homocysteine metabolic process (GO:0050667)	4.03447715
56	fructose metabolic process (GO:0006000)	4.02919545
57	fat-soluble vitamin biosynthetic process (GO:0042362)	3.96214530
58	bile acid metabolic process (GO:0008206)	3.96121885
59	plasma lipoprotein particle assembly (GO:0034377)	3.94502332
60	acylglycerol homeostasis (GO:0055090)	3.92096401
61	triglyceride homeostasis (GO:0070328)	3.92096401
62	triglyceride catabolic process (GO:0019433)	3.90129926
63	neutral lipid catabolic process (GO:0046461)	3.88522871
64	acylglycerol catabolic process (GO:0046464)	3.88522871
65	low-density lipoprotein particle remodeling (GO:0034374)	3.87461579
66	lipoprotein transport (GO:0042953)	3.84005366
67	amine catabolic process (GO:0009310)	3.83835197
68	cellular biogenic amine catabolic process (GO:0042402)	3.83835197
69	regulation of bile acid biosynthetic process (GO:0070857)	3.78825256
70	cellular ketone body metabolic process (GO:0046950)	3.75949743
71	glycine metabolic process (GO:0006544)	3.74576163
72	ethanol metabolic process (GO:0006067)	3.73051700
73	drug metabolic process (GO:0017144)	3.72854788
74	alpha-amino acid catabolic process (GO:1901606)	3.71397421
75	fibrinolysis (GO:0042730)	3.69557515
76	phospholipid homeostasis (GO:0055091)	3.68984515
77	positive regulation of triglyceride lipase activity (GO:0061365)	3.65256603
78	positive regulation of lipoprotein lipase activity (GO:0051006)	3.65256603
79	indolalkylamine metabolic process (GO:0006586)	3.61930657
80	serine family amino acid metabolic process (GO:0009069)	3.61701377
81	tyrosine metabolic process (GO:0006570)	3.61123104
82	protein-lipid complex assembly (GO:0065005)	3.60787248
83	plasma lipoprotein particle organization (GO:0071827)	3.60197960
84	urate metabolic process (GO:0046415)	3.57854144
85	cellular glucuronidation (GO:0052695)	3.55490240
86	cofactor catabolic process (GO:0051187)	3.55112057
87	bile acid and bile salt transport (GO:0015721)	3.51827703
88	lipoprotein metabolic process (GO:0042157)	3.51115283
89	intestinal cholesterol absorption (GO:0030299)	3.50817145
90	cholesterol homeostasis (GO:0042632)	3.48252652
91	arginine metabolic process (GO:0006525)	3.47272594
92	benzene-containing compound metabolic process (GO:0042537)	3.46965441
93	very-low-density lipoprotein particle assembly (GO:0034379)	3.44783099
94	cellular amino acid catabolic process (GO:0009063)	3.44734696
95	sterol homeostasis (GO:0055092)	3.44565995
96	protein-lipid complex subunit organization (GO:0071825)	3.42834645
97	drug catabolic process (GO:0042737)	3.40554121
98	protein activation cascade (GO:0072376)	3.39142090
99	glucuronate metabolic process (GO:0019585)	3.39086927
100	uronic acid metabolic process (GO:0006063)	3.39086927
101	L-ascorbic acid metabolic process (GO:0019852)	3.37266239
102	blood coagulation, intrinsic pathway (GO:0007597)	3.36131570
103	fatty acid homeostasis (GO:0055089)	3.35404253
104	positive regulation of lipid catabolic process (GO:0050996)	3.35320681
105	NAD biosynthetic process (GO:0009435)	3.35267630
106	regulation of cholesterol homeostasis (GO:2000188)	3.32070663
107	complement activation (GO:0006956)	3.32051198
108	cellular modified amino acid catabolic process (GO:0042219)	3.30140421
109	exogenous drug catabolic process (GO:0042738)	3.30127798
110	omega-hydroxylase P450 pathway (GO:0097267)	3.29636331
111	acute-phase response (GO:0006953)	3.28952785
112	flavonoid metabolic process (GO:0009812)	3.27424056
113	drug transmembrane transport (GO:0006855)	3.25701549
114	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.24579277
115	pyridine nucleotide biosynthetic process (GO:0019363)	3.24579277
116	serine family amino acid biosynthetic process (GO:0009070)	3.21665227
117	complement activation, classical pathway (GO:0006958)	3.21367318
118	ketone body metabolic process (GO:1902224)	3.20163792
119	organic acid catabolic process (GO:0016054)	3.19683356
120	carboxylic acid catabolic process (GO:0046395)	3.19683356
121	glutamate metabolic process (GO:0006536)	3.17571462
122	coenzyme catabolic process (GO:0009109)	3.15748843
123	carnitine metabolic process (GO:0009437)	3.15263489
124	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.14469523
125	negative regulation of protein activation cascade (GO:2000258)	3.14365202
126	fatty acid beta-oxidation (GO:0006635)	3.14046046
127	primary alcohol metabolic process (GO:0034308)	3.11529837
128	oxaloacetate metabolic process (GO:0006107)	3.07365444
129	oligosaccharide catabolic process (GO:0009313)	3.03898431
130	negative regulation of hemostasis (GO:1900047)	3.03231586
131	negative regulation of blood coagulation (GO:0030195)	3.03231586
132	lipid homeostasis (GO:0055088)	3.01399676
133	glycosphingolipid catabolic process (GO:0046479)	3.01174135
134	hormone catabolic process (GO:0042447)	3.00372217
135	polyketide metabolic process (GO:0030638)	2.98477192
136	doxorubicin metabolic process (GO:0044598)	2.98477192
137	daunorubicin metabolic process (GO:0044597)	2.98477192
138	glycerolipid catabolic process (GO:0046503)	2.97762908
139	regulation of sterol transport (GO:0032371)	2.96646416
140	regulation of cholesterol transport (GO:0032374)	2.96646416
141	regulation of lipoprotein metabolic process (GO:0050746)	2.95879833
142	positive regulation of glycolytic process (GO:0045821)	2.94744294
143	regulation of cholesterol storage (GO:0010885)	2.92183138

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.43583789
2	* RXR_22158963_ChIP-Seq_LIVER_Mouse	6.68207453
3	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.86563261
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.53637831
5	* LXR_22158963_ChIP-Seq_LIVER_Mouse	5.11827955
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.71761973
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.28994971
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.15949679
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.17261553
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.07214794
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.94317323
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.80587675
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.53330497
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22414125
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.21689274
16	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.06902472
17	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.89819209
18	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.86791572
19	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.81641981
20	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.80866252
21	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.78832218
22	* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.74538078
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.69054804
24	* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.65960139
25	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.63942232
26	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.59287112
27	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.56237502
28	CLOCK_20551151_ChIP-Seq_293T_Human	1.53787799
29	* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.50895136
30	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.45799580
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.32663888
32	GATA1_22025678_ChIP-Seq_K562_Human	1.29072032
33	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.25014190
34	* FOXO3_23340844_ChIP-Seq_DLD1_Human	1.23941841
35	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.23183998
36	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17290685
37	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.15883732
38	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.12255510
39	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.12150121
40	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.11190429
41	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.10818115
42	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.10154928
43	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.08865881
44	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07593195
45	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07509232
46	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.07030530
47	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.06197361
48	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.05190529
49	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.04811400
50	RACK7_27058665_Chip-Seq_MCF-7_Human	1.04035016
51	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.03976106
52	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02529903
53	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.02177717
54	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.01742708
55	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.01648544
56	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.01532375
57	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.00510506
58	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.99522232
59	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.98525600
60	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.97366062
61	* FOXA2_19822575_ChIP-Seq_HepG2_Human	0.96785388
62	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.95298356
63	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.95059827
64	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.93714143
65	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.93225859
66	SA1_27219007_Chip-Seq_Bcells_Human	0.91460524
67	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91414251
68	* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.91228026
69	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.90494952
70	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.90257214
71	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88515088
72	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88242422
73	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.87206274
74	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.87020490
75	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.85681110
76	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.85113375
77	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.84858590
78	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.84745239
79	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.84422991
80	SOX2_20726797_ChIP-Seq_SW620_Human	0.83486700
81	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.80892323
82	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.80813824
83	* CDX2_20551321_ChIP-Seq_CACO-2_Human	0.80751651
84	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.80306761
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.80162322
86	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.77840442
87	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.77719611
88	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.77154788
89	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.76860657
90	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.76017238
91	BCOR_27268052_Chip-Seq_Bcells_Human	0.75798856
92	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.75506715
93	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.75501659
94	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.75419503
95	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.75419503
96	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.74900086
97	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.74715741
98	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.73492329
99	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.73481261
100	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.73460031
101	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.73358629
102	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.73212793
103	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.73161558
104	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.72253601
105	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.72230003
106	CTCF_27219007_Chip-Seq_Bcells_Human	0.72228229
107	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.71935030
108	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.71892724
109	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.71761242
110	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.71740075
111	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.71505595
112	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.71061151
113	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.70430502
114	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.70430502
115	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.70390097
116	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.69889060
117	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.69403730
118	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.68546831
119	CDX2_22108803_ChIP-Seq_LS180_Human	0.67751333
120	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.67688208
121	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.67523281
122	EGR1_19032775_ChIP-ChIP_M12_Human	0.66277547
123	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.66038767
124	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.65858236
125	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.65756980
126	* SPI1_23547873_ChIP-Seq_NB4_Human	0.64535485
127	LXR_22292898_ChIP-Seq_THP-1_Human	0.63742053
128	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.63021555
129	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.63001975
130	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.61783663
131	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.61592101
132	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.61122471
133	GATA6_25053715_ChIP-Seq_YYC3_Human	0.60196102
134	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.60130176
135	* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.59583865
136	ZNF263_19887448_ChIP-Seq_K562_Human	0.59039134
137	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.58012548
138	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.57745167
139	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.57014239
140	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.55687190
141	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.55165987

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.45284018
2	MP0005360_urolithiasis	6.30044022
3	MP0005085_abnormal_gallbladder_physiolo	4.88452533
4	MP0005365_abnormal_bile_salt	4.67757187
5	MP0008875_abnormal_xenobiotic_pharmacok	3.84289095
6	MP0009840_abnormal_foam_cell	3.79330113
7	MP0003806_abnormal_nucleotide_metabolis	3.20377627
8	MP0003191_abnormal_cellular_cholesterol	3.12932173
9	MP0010329_abnormal_lipoprotein_level	3.06822447
10	MP0003252_abnormal_bile_duct	2.94842884
11	MP0005332_abnormal_amino_acid	2.69101661
12	MP0002138_abnormal_hepatobiliary_system	2.53531202
13	MP0004019_abnormal_vitamin_homeostasis	2.52900635
14	MP0003195_calcinosis	2.41287131
15	MP0005083_abnormal_biliary_tract	2.40351634
16	MP0001666_abnormal_nutrient_absorption	2.21512117
17	MP0005058_abnormal_lysosome_morphology	2.18599471
18	MP0005666_abnormal_adipose_tissue	2.09948253
19	MP0000609_abnormal_liver_physiology	1.97788528
20	MP0003436_decreased_susceptibility_to	1.83945794
21	MP0003186_abnormal_redox_activity	1.83788474
22	MP0005319_abnormal_enzyme/_coenzyme	1.76808534
23	MP0002118_abnormal_lipid_homeostasis	1.73748825
24	MP0003724_increased_susceptibility_to	1.71596092
25	MP0010368_abnormal_lymphatic_system	1.66813295
26	MP0009643_abnormal_urine_homeostasis	1.64024342
27	MP0002909_abnormal_adrenal_gland	1.60986108
28	MP0005375_adipose_tissue_phenotype	1.57229452
29	MP0003183_abnormal_peptide_metabolism	1.56856202
30	MP0001835_abnormal_antigen_presentation	1.49106694
31	MP0005451_abnormal_body_composition	1.47714883
32	MP0009764_decreased_sensitivity_to	1.46810722
33	MP0006082_CNS_inflammation	1.45798066
34	MP0005584_abnormal_enzyme/coenzyme_acti	1.43662668
35	MP0001764_abnormal_homeostasis	1.42636568
36	MP0009115_abnormal_fat_cell	1.42190459
37	MP0003879_abnormal_hair_cell	1.41858457
38	MP0003011_delayed_dark_adaptation	1.39560104
39	MP0008469_abnormal_protein_level	1.39017600
40	MP0002148_abnormal_hypersensitivity_rea	1.35484761
41	MP0009785_altered_susceptibility_to	1.35067540
42	MP0009697_abnormal_copulation	1.34090287
43	MP0010234_abnormal_vibrissa_follicle	1.32494205
44	MP0005464_abnormal_platelet_physiology	1.31298130
45	MP0005448_abnormal_energy_balance	1.27479018
46	MP0002419_abnormal_innate_immunity	1.26295218
47	MP0002254_reproductive_system_inflammat	1.25493926
48	MP0000604_amyloidosis	1.24079607
49	MP0003172_abnormal_lysosome_physiology	1.17356710
50	MP0000598_abnormal_liver_morphology	1.16476674
51	MP0009763_increased_sensitivity_to	1.16400288
52	MP0004264_abnormal_extraembryonic_tissu	1.14577118
53	MP0005670_abnormal_white_adipose	1.12852877
54	MP0004782_abnormal_surfactant_physiolog	1.11134932
55	MP0001756_abnormal_urination	1.09698488
56	MP0009780_abnormal_chondrocyte_physiolo	1.09435814
57	MP0003705_abnormal_hypodermis_morpholog	1.09045961
58	MP0005025_abnormal_response_to	1.08188377
59	MP0003656_abnormal_erythrocyte_physiolo	1.07730142
60	MP0003868_abnormal_feces_composition	1.06279504
61	MP0000003_abnormal_adipose_tissue	1.05425457
62	MP0005636_abnormal_mineral_homeostasis	1.04872812
63	MP0002136_abnormal_kidney_physiology	1.02321263
64	MP0002970_abnormal_white_adipose	1.01936837
65	MP0001845_abnormal_inflammatory_respons	0.96487833
66	MP0004043_abnormal_pH_regulation	0.96143113
67	MP0003122_maternal_imprinting	0.95561051
68	MP0001661_extended_life_span	0.92403063
69	MP0005084_abnormal_gallbladder_morpholo	0.92360517
70	MP0001853_heart_inflammation	0.92198408
71	MP0009642_abnormal_blood_homeostasis	0.91180337
72	MP0004185_abnormal_adipocyte_glucose	0.90157401
73	MP0001533_abnormal_skeleton_physiology	0.89432261
74	MP0000343_altered_response_to	0.88245097
75	MP0005000_abnormal_immune_tolerance	0.87942579
76	MP0004883_abnormal_blood_vessel	0.87279855
77	MP0004272_abnormal_basement_membrane	0.86228910
78	MP0005166_decreased_susceptibility_to	0.83910557
79	MP0003953_abnormal_hormone_level	0.83578181
80	MP0003959_abnormal_lean_body	0.83433340
81	MP0005379_endocrine/exocrine_gland_phen	0.83199919
82	MP0001765_abnormal_ion_homeostasis	0.83117395
83	MP0003690_abnormal_glial_cell	0.82249968
84	MP0005376_homeostasis/metabolism_phenot	0.81636282
85	MP0003075_altered_response_to	0.80080188
86	MP0005167_abnormal_blood-brain_barrier	0.79918007
87	MP0003283_abnormal_digestive_organ	0.79370100
88	MP0005409_darkened_coat_color	0.79314686
89	MP0005164_abnormal_response_to	0.78196411
90	MP0005408_hypopigmentation	0.77819621
91	MP0000249_abnormal_blood_vessel	0.77717318
92	MP0000685_abnormal_immune_system	0.76618424
93	MP0006036_abnormal_mitochondrial_physio	0.76112739
94	MP0010155_abnormal_intestine_physiology	0.74926106
95	MP0001542_abnormal_bone_strength	0.74523411
96	MP0008004_abnormal_stomach_pH	0.73923206
97	MP0003303_peritoneal_inflammation	0.71145253
98	MP0002452_abnormal_antigen_presenting	0.71032400
99	MP0002723_abnormal_immune_serum	0.69797578
100	MP0002971_abnormal_brown_adipose	0.69573200
101	MP0001790_abnormal_immune_system	0.68908833
102	MP0005387_immune_system_phenotype	0.68908833
103	MP0000013_abnormal_adipose_tissue	0.68301376
104	MP0003718_maternal_effect	0.67573236
105	MP0001800_abnormal_humoral_immune	0.66142344
106	MP0003329_amyloid_beta_deposits	0.64985478
107	MP0002405_respiratory_system_inflammati	0.64492333
108	MP0002132_abnormal_respiratory_system	0.64361202
109	MP0005671_abnormal_response_to	0.63665881
110	MP0002933_joint_inflammation	0.62712582
111	MP0004947_skin_inflammation	0.62439229
112	MP0005257_abnormal_intraocular_pressure	0.61679905
113	MP0005395_other_phenotype	0.61429573
114	MP0004130_abnormal_muscle_cell	0.61100730
115	MP0005647_abnormal_sex_gland	0.61047514
116	MP0001944_abnormal_pancreas_morphology	0.60456485
117	MP0001879_abnormal_lymphatic_vessel	0.59992167
118	MP0000462_abnormal_digestive_system	0.59804102
119	MP0002876_abnormal_thyroid_physiology	0.59468279
120	MP0009765_abnormal_xenobiotic_induced	0.59389762
121	MP0005334_abnormal_fat_pad	0.58792039
122	MP0000538_abnormal_urinary_bladder	0.58086698
123	MP0003638_abnormal_response/metabolism_	0.57509005
124	MP0005452_abnormal_adipose_tissue	0.56995915
125	MP0000477_abnormal_intestine_morphology	0.56173147
126	MP0002135_abnormal_kidney_morphology	0.55210101
127	MP0008873_increased_physiological_sensi	0.55100751
128	MP0009053_abnormal_anal_canal	0.55088121
129	MP0002295_abnormal_pulmonary_circulatio	0.54182290
130	MP0006054_spinal_hemorrhage	0.54141727
131	MP0002078_abnormal_glucose_homeostasis	0.54127843
132	MP0005023_abnormal_wound_healing	0.53203271
133	MP0003300_gastrointestinal_ulcer	0.52924907
134	MP0000230_abnormal_systemic_arterial	0.51986089
135	MP0002090_abnormal_vision	0.51928763
136	MP0002896_abnormal_bone_mineralization	0.51860675
137	MP0005535_abnormal_body_temperature	0.51434396
138	MP0002089_abnormal_postnatal_growth/wei	0.49836703
139	MP0002998_abnormal_bone_remodeling	0.49650044
140	MP0004147_increased_porphyrin_level	0.49187224
141	MP0003123_paternal_imprinting	0.48786435

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.58074292
2	Deep venous thrombosis (HP:0002625)	5.56544796
3	Xanthomatosis (HP:0000991)	5.34606849
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.21815707
5	Intrahepatic cholestasis (HP:0001406)	5.16873293
6	Prolonged partial thromboplastin time (HP:0003645)	5.11778079
7	Complement deficiency (HP:0004431)	4.95745603
8	Systemic lupus erythematosus (HP:0002725)	4.84886074
9	Joint hemorrhage (HP:0005261)	4.77559819
10	Hypobetalipoproteinemia (HP:0003563)	4.77442638
11	Hyperlipoproteinemia (HP:0010980)	4.21215108
12	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.03572978
13	Hypolipoproteinemia (HP:0010981)	4.03152257
14	Abnormality of complement system (HP:0005339)	3.98764232
15	Hyperglycinuria (HP:0003108)	3.96233506
16	Hypoalphalipoproteinemia (HP:0003233)	3.87582839
17	Hyperglycinemia (HP:0002154)	3.85586346
18	Abnormality of the common coagulation pathway (HP:0010990)	3.82928796
19	Glomerulonephritis (HP:0000099)	3.82217179
20	Hyperammonemia (HP:0001987)	3.79662249
21	Recurrent gram-negative bacterial infections (HP:0005420)	3.70782272
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.64820054
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.63730820
24	Abnormality of glycine metabolism (HP:0010895)	3.61022048
25	Abnormality of serine family amino acid metabolism (HP:0010894)	3.61022048
26	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.52182480
27	Hypoglycemic coma (HP:0001325)	3.50322770
28	Abnormality of fatty-acid metabolism (HP:0004359)	3.40054026
29	Abnormality of methionine metabolism (HP:0010901)	3.34416330
30	Ketosis (HP:0001946)	3.29788103
31	Abnormality of pyrimidine metabolism (HP:0004353)	3.27770198
32	Fat malabsorption (HP:0002630)	3.23402137
33	Epidermoid cyst (HP:0200040)	3.16075010
34	Abnormality of the intrinsic pathway (HP:0010989)	3.15685270
35	Vacuolated lymphocytes (HP:0001922)	3.15120846
36	Hypercholesterolemia (HP:0003124)	2.99389084
37	Abnormality of nucleobase metabolism (HP:0010932)	2.98928091
38	Myocardial infarction (HP:0001658)	2.95580904
39	Abnormality of purine metabolism (HP:0004352)	2.84507037
40	Generalized aminoaciduria (HP:0002909)	2.77211573
41	Axonal loss (HP:0003447)	2.75650225
42	Abnormality of serum amino acid levels (HP:0003112)	2.75642131
43	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.75286801
44	Gout (HP:0001997)	2.74164036
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.73652692
46	Dicarboxylic aciduria (HP:0003215)	2.73652692
47	Nephritis (HP:0000123)	2.68502078
48	Nausea (HP:0002018)	2.64009601
49	Proximal tubulopathy (HP:0000114)	2.63967051
50	Abnormality of liposaccharide metabolism (HP:0010968)	2.62284052
51	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.62284052
52	Abnormality of glycolipid metabolism (HP:0010969)	2.62284052
53	Urinary glycosaminoglycan excretion (HP:0003541)	2.60182764
54	Mucopolysacchariduria (HP:0008155)	2.60182764
55	Vascular calcification (HP:0004934)	2.57247516
56	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.56449285
57	Abnormality of polysaccharide metabolism (HP:0011012)	2.56449285
58	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.56449285
59	Facial shape deformation (HP:0011334)	2.54525076
60	Potter facies (HP:0002009)	2.54525076
61	Steatorrhea (HP:0002570)	2.53030598
62	Hyperbilirubinemia (HP:0002904)	2.52455409
63	Eczematoid dermatitis (HP:0000976)	2.50184874
64	Recurrent bacterial skin infections (HP:0005406)	2.49395540
65	Ileus (HP:0002595)	2.49274047
66	Metabolic acidosis (HP:0001942)	2.49264226
67	Hyperinsulinemic hypoglycemia (HP:0000825)	2.48187634
68	Conjugated hyperbilirubinemia (HP:0002908)	2.47174914
69	Ketoacidosis (HP:0001993)	2.45241703
70	Symptomatic seizures (HP:0011145)	2.44719854
71	Lethargy (HP:0001254)	2.42984119
72	Abnormality of vitamin metabolism (HP:0100508)	2.42593057
73	Delayed CNS myelination (HP:0002188)	2.41721487
74	Retinal atrophy (HP:0001105)	2.40527790
75	Abnormality of magnesium homeostasis (HP:0004921)	2.36850405
76	Hepatocellular carcinoma (HP:0001402)	2.35176808
77	Esophageal varix (HP:0002040)	2.33814687
78	Pigmentary retinal degeneration (HP:0001146)	2.33350181
79	Menorrhagia (HP:0000132)	2.33083111
80	Spontaneous abortion (HP:0005268)	2.31536410
81	Nuclear cataract (HP:0100018)	2.28723233
82	Cardiovascular calcification (HP:0011915)	2.26742753
83	Hypophosphatemia (HP:0002148)	2.26479163
84	Hyperphosphaturia (HP:0003109)	2.26409322
85	Widely patent fontanelles and sutures (HP:0004492)	2.22192676
86	Malnutrition (HP:0004395)	2.21394277
87	Abnormality of proline metabolism (HP:0010907)	2.20708027
88	Hydroxyprolinuria (HP:0003080)	2.20708027
89	Abnormality of urine glucose concentration (HP:0011016)	2.20690678
90	Glycosuria (HP:0003076)	2.20690678
91	Pancreatitis (HP:0001733)	2.19990587
92	Hyperactive renin-angiotensin system (HP:0000841)	2.17095937
93	Gingival bleeding (HP:0000225)	2.15238665
94	Metabolic alkalosis (HP:0200114)	2.14336647
95	Hyperuricemia (HP:0002149)	2.13732743
96	Increased purine levels (HP:0004368)	2.13732743
97	Skin nodule (HP:0200036)	2.12160882
98	Acanthocytosis (HP:0001927)	2.11824708
99	Recurrent abscess formation (HP:0002722)	2.10900375
100	Hemorrhage of the eye (HP:0011885)	2.09056236
101	Amyloidosis (HP:0011034)	2.08287759
102	Vomiting (HP:0002013)	2.06528664
103	Insulin resistance (HP:0000855)	2.06403869
104	Abnormality of renin-angiotensin system (HP:0000847)	2.06321908
105	Irritability (HP:0000737)	2.06112712
106	Hyperglycemia (HP:0003074)	2.05883263
107	Increased circulating renin level (HP:0000848)	2.04773844
108	Abnormal urine phosphate concentration (HP:0012599)	2.03891174
109	Hypomagnesemia (HP:0002917)	2.03680317
110	Abnormal cartilage morphology (HP:0002763)	2.03254919
111	Hypotension (HP:0002615)	2.02768889
112	Thrombophlebitis (HP:0004418)	2.02256393
113	Hypophosphatemic rickets (HP:0004912)	1.98703364
114	Prolonged neonatal jaundice (HP:0006579)	1.96290297
115	Abnormality of iron homeostasis (HP:0011031)	1.95251056
116	Sensorimotor neuropathy (HP:0007141)	1.94979269
117	Abnormality of carpal bone ossification (HP:0006257)	1.94079663
118	Cerebral edema (HP:0002181)	1.93406633
119	Abnormality of macrophages (HP:0004311)	1.93138005
120	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.92575775
121	Alkalosis (HP:0001948)	1.92471295
122	Late onset (HP:0003584)	1.90841873
123	Abnormal tarsal ossification (HP:0008369)	1.90717936
124	Autoimmune thrombocytopenia (HP:0001973)	1.90225936
125	Acanthosis nigricans (HP:0000956)	1.89802388
126	Abnormality of transition element cation homeostasis (HP:0011030)	1.89423232
127	Insulin-resistant diabetes mellitus (HP:0000831)	1.88629681
128	Upper motor neuron abnormality (HP:0002127)	1.86803137
129	Hypoglycemic seizures (HP:0002173)	1.86548576
130	Rickets (HP:0002748)	1.85541140
131	Dysostosis multiplex (HP:0000943)	1.84052346
132	Hypertriglyceridemia (HP:0002155)	1.81019703
133	Purpura (HP:0000979)	1.80407797
134	Mitral stenosis (HP:0001718)	1.79656651
135	Renal cortical cysts (HP:0000803)	1.77208901
136	Abnormal enzyme/coenzyme activity (HP:0012379)	1.77036179

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.50777343
2	RIPK1	3.62831975
3	ERN1	3.50743111
4	BLK	3.04792869
5	FGFR4	2.79580008
6	IRAK3	2.75358730
7	NEK9	2.65188685
8	TYK2	2.60664633
9	KDR	2.56284497
10	NME2	2.50491484
11	FGFR3	2.45642465
12	MST1R	2.39809345
13	TGFBR2	2.38373207
14	DDR2	2.38117098
15	LMTK2	2.23874614
16	MAP3K14	2.18968282
17	MAP3K2	2.09997673
18	TAOK3	2.04148945
19	ABL2	1.97322778
20	TBK1	1.94273864
21	MAPKAPK3	1.91288835
22	SIK1	1.91155006
23	MAP3K12	1.90979045
24	MAP2K3	1.88699997
25	PIK3CG	1.88615788
26	PBK	1.87423847
27	TIE1	1.67811280
28	MAP3K11	1.65482085
29	TRIB3	1.51908217
30	STK16	1.46850033
31	IRAK4	1.45217730
32	PIM2	1.44894236
33	PDPK1	1.41898591
34	JAK1	1.35913534
35	MAP3K3	1.35483459
36	OXSR1	1.34108910
37	MAP3K1	1.31639515
38	FGFR2	1.30701530
39	WNK4	1.29773559
40	IKBKB	1.25037105
41	EEF2K	1.24341693
42	NLK	1.22769902
43	PDGFRA	1.21746658
44	EIF2AK1	1.17829035
45	STK39	1.15968830
46	MET	1.14005473
47	ZAP70	1.13873305
48	IKBKE	1.13824767
49	MAPK11	1.11824124
50	JAK2	1.11403234
51	PKN2	1.07566983
52	PDK2	1.06448959
53	PRKACG	1.04211455
54	GRK7	1.01256511
55	CDC42BPA	0.98811209
56	EPHA2	0.96936153
57	STK38L	0.95523929
58	EPHB1	0.93338084
59	MAP4K1	0.93192046
60	PTK6	0.92358253
61	RPS6KA4	0.91551893
62	ERBB4	0.91477122
63	INSRR	0.90675772
64	STK10	0.89905297
65	CSK	0.89624263
66	FRK	0.89133687
67	BTK	0.88943719
68	EPHB2	0.88367486
69	FER	0.88058055
70	PRKAA1	0.84910895
71	BMX	0.82758107
72	PDK1	0.80254769
73	ICK	0.77025298
74	TXK	0.76639851
75	TEC	0.75591433
76	NUAK1	0.75433578
77	KIT	0.73887392
78	RIPK4	0.73358187
79	MAP2K6	0.72968572
80	PAK4	0.72728519
81	MAP2K2	0.72476432
82	LYN	0.72002999
83	CAMKK2	0.71327285
84	CSF1R	0.71191928
85	DAPK2	0.71100558
86	MST4	0.69489205
87	TAOK2	0.68607621
88	CDK6	0.67542342
89	FLT3	0.66928243
90	GRK1	0.66511218
91	PIM1	0.66050672
92	TGFBR1	0.65168018
93	AKT3	0.64304060
94	STK24	0.63280430
95	LATS2	0.62844312
96	LRRK2	0.62469693
97	ACVR1B	0.62099675
98	LATS1	0.61889278
99	RET	0.61504255
100	JAK3	0.60237740
101	MATK	0.59801317
102	MOS	0.58114983
103	PRKG2	0.57494368
104	TRPM7	0.56302242
105	CHUK	0.55082513
106	DMPK	0.54037779
107	MYLK	0.53353193
108	SRC	0.51827632
109	TAOK1	0.51651293
110	WNK3	0.51503354
111	MAPK12	0.51129039
112	PRKG1	0.49399991
113	FGR	0.48690527
114	EIF2AK2	0.47422260
115	PRKAA2	0.47060814
116	SGK494	0.46915273
117	SGK223	0.46915273
118	PRKCZ	0.46609074
119	PRKCD	0.46431240
120	CAMK1D	0.46301922
121	YES1	0.45703691
122	TESK1	0.45473145
123	MAP2K1	0.44664224
124	MAP3K5	0.44635035
125	EGFR	0.43939941
126	ARAF	0.43694505
127	IRAK1	0.42606367
128	IGF1R	0.41831756
129	HCK	0.41672447
130	GRK6	0.41341092
131	PRKCA	0.40525721
132	DYRK1B	0.38734151
133	MAPK4	0.38050100
134	PRPF4B	0.37894413
135	EPHA3	0.37504473
136	GSK3A	0.37107727
137	MAP3K13	0.36944674
138	CAMK2D	0.36373670
139	PTK2	0.36266374
140	TESK2	0.36199141
141	PIK3CA	0.35431109
142	ERBB2	0.34697014
143	ABL1	0.34502312
144	NTRK3	0.34313734
145	PRKACA	0.34124449
146	SYK	0.34070088
147	AKT2	0.29222356

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.94632191
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.24840849
3	Complement and coagulation cascades_Homo sapiens_hsa04610	3.05993870
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.85093084
5	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.77131057
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.73115614
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.68567239
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.62435509
9	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.60777305
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.46538232
11	Fatty acid degradation_Homo sapiens_hsa00071	2.41533849
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.34324706
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.28041108
14	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.19038582
15	Peroxisome_Homo sapiens_hsa04146	2.13034439
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.00324063
17	PPAR signaling pathway_Homo sapiens_hsa03320	1.93895613
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.86154779
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.84840204
20	Histidine metabolism_Homo sapiens_hsa00340	1.84264179
21	Butanoate metabolism_Homo sapiens_hsa00650	1.82637071
22	Propanoate metabolism_Homo sapiens_hsa00640	1.75605660
23	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.72381528
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.67687662
25	Retinol metabolism_Homo sapiens_hsa00830	1.60280399
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.59073031
27	Fatty acid metabolism_Homo sapiens_hsa01212	1.57695738
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.55587458
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.51419468
30	Caffeine metabolism_Homo sapiens_hsa00232	1.50100832
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.48077960
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43906993
33	Folate biosynthesis_Homo sapiens_hsa00790	1.43827647
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.43737314
35	Sulfur metabolism_Homo sapiens_hsa00920	1.37459489
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.35682212
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31653593
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.30620265
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.27496906
40	Bile secretion_Homo sapiens_hsa04976	1.24050694
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22112912
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.14263544
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12529279
44	Carbon metabolism_Homo sapiens_hsa01200	1.12382182
45	Fatty acid elongation_Homo sapiens_hsa00062	1.11926849
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11676496
47	Sulfur relay system_Homo sapiens_hsa04122	1.10439730
48	Tyrosine metabolism_Homo sapiens_hsa00350	1.08732364
49	Pyruvate metabolism_Homo sapiens_hsa00620	1.05648977
50	Steroid biosynthesis_Homo sapiens_hsa00100	1.03213895
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02821251
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.02326700
53	Glutathione metabolism_Homo sapiens_hsa00480	0.99978369
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99230032
55	ABC transporters_Homo sapiens_hsa02010	0.98140291
56	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.95272697
57	One carbon pool by folate_Homo sapiens_hsa00670	0.79647150
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.79058212
59	Pentose phosphate pathway_Homo sapiens_hsa00030	0.77778079
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77670205
61	Lysosome_Homo sapiens_hsa04142	0.70302446
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67321025
63	Other glycan degradation_Homo sapiens_hsa00511	0.67148299
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64472033
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64391885
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62562478
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62544845
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61667302
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60195246
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57913971
71	Galactose metabolism_Homo sapiens_hsa00052	0.55747713
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54512104
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.53780717
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52259728
75	Lysine degradation_Homo sapiens_hsa00310	0.49823781
76	Metabolic pathways_Homo sapiens_hsa01100	0.48711162
77	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46854761
78	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.43703282
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41027041
80	Pertussis_Homo sapiens_hsa05133	0.40663124
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37958426
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.37404330
83	Prion diseases_Homo sapiens_hsa05020	0.36526000
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35531512
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33123419
86	Leishmaniasis_Homo sapiens_hsa05140	0.28442857
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.28098796
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28084286
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.27977415
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.27759109
91	Legionellosis_Homo sapiens_hsa05134	0.26081542
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.26073652
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25906991
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.25170297
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.24372103
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.22419014
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.20352160
98	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.19913725
99	Phagosome_Homo sapiens_hsa04145	0.19279119
100	Malaria_Homo sapiens_hsa05144	0.19226060
101	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.19169856
102	Vibrio cholerae infection_Homo sapiens_hsa05110	0.16256800
103	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.15567481
104	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.14937487
105	Insulin resistance_Homo sapiens_hsa04931	0.13988478
106	Tuberculosis_Homo sapiens_hsa05152	0.11770492
107	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.11672858
108	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.11371539
109	Mineral absorption_Homo sapiens_hsa04978	0.11337158
110	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.10665888
111	Collecting duct acid secretion_Homo sapiens_hsa04966	0.10519706
112	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.09097177
113	Type I diabetes mellitus_Homo sapiens_hsa04940	0.08020879
114	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.07477555
115	Hepatitis C_Homo sapiens_hsa05160	0.07292882
116	Osteoclast differentiation_Homo sapiens_hsa04380	0.07100004
117	Proteasome_Homo sapiens_hsa03050	0.06696012
118	Insulin signaling pathway_Homo sapiens_hsa04910	0.06441662
119	Asthma_Homo sapiens_hsa05310	0.06120273
120	Rheumatoid arthritis_Homo sapiens_hsa05323	0.04275752

TMEM37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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