TMEM39A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ER overload response (GO:0006983)5.21893780
2regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.75381799
3anterior/posterior axis specification, embryo (GO:0008595)4.21122065
4nucleotide-sugar biosynthetic process (GO:0009226)3.94684771
5rRNA methylation (GO:0031167)3.76935613
6L-alpha-amino acid transmembrane transport (GO:1902475)3.72852467
7COPI coating of Golgi vesicle (GO:0048205)3.61556330
8Golgi transport vesicle coating (GO:0048200)3.61556330
9folic acid-containing compound biosynthetic process (GO:0009396)3.60607389
10formation of translation preinitiation complex (GO:0001731)3.59809956
11regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.57240233
12negative regulation of glucose import (GO:0046325)3.49895720
13mitotic metaphase plate congression (GO:0007080)3.38148980
14dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.29262086
15NIK/NF-kappaB signaling (GO:0038061)3.28348786
16mitotic nuclear envelope disassembly (GO:0007077)3.24438709
17peptidyl-histidine modification (GO:0018202)3.23588631
18nuclear pore organization (GO:0006999)3.19014561
19ribosomal small subunit assembly (GO:0000028)3.12463292
20nucleotide-sugar metabolic process (GO:0009225)3.07866151
21ribosome assembly (GO:0042255)3.04906125
22protein N-linked glycosylation via asparagine (GO:0018279)3.04791490
23peptidyl-asparagine modification (GO:0018196)3.04517057
24endoplasmic reticulum unfolded protein response (GO:0030968)3.03716466
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.02961184
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02961184
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02961184
28activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.02755583
29signal peptide processing (GO:0006465)3.02655334
30nuclear envelope disassembly (GO:0051081)2.96120702
31membrane disassembly (GO:0030397)2.96120702
32regulation of spindle organization (GO:0090224)2.95386909
33positive regulation of nuclease activity (GO:0032075)2.93794041
34DNA replication initiation (GO:0006270)2.92464919
35ER to Golgi vesicle-mediated transport (GO:0006888)2.91930615
36cellular response to unfolded protein (GO:0034620)2.91779494
37nucleobase biosynthetic process (GO:0046112)2.89301644
38metaphase plate congression (GO:0051310)2.88075839
39regulation of DNA endoreduplication (GO:0032875)2.87743952
40skin morphogenesis (GO:0043589)2.87225420
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82858183
42DNA strand elongation involved in DNA replication (GO:0006271)2.82302192
43nuclear pore complex assembly (GO:0051292)2.82252525
44maturation of SSU-rRNA (GO:0030490)2.80409019
45protein N-linked glycosylation (GO:0006487)2.79213389
46ER-nucleus signaling pathway (GO:0006984)2.76729522
47interleukin-6-mediated signaling pathway (GO:0070102)2.75716294
48protein targeting to ER (GO:0045047)2.73871145
49cotranslational protein targeting to membrane (GO:0006613)2.73014226
50synapsis (GO:0007129)2.72948536
51DNA strand elongation (GO:0022616)2.70287142
52regulation of nuclease activity (GO:0032069)2.70002220
53protein localization to kinetochore (GO:0034501)2.68774979
54DNA replication checkpoint (GO:0000076)2.68699022
55zinc ion transport (GO:0006829)2.68082166
56purine nucleobase biosynthetic process (GO:0009113)2.67535299
57establishment of chromosome localization (GO:0051303)2.66789916
58regulation of mitotic spindle organization (GO:0060236)2.66771626
59protein hydroxylation (GO:0018126)2.65515029
60negative regulation of complement activation (GO:0045916)2.64570312
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.64423445
62positive regulation of protein autophosphorylation (GO:0031954)2.61629745
63cellular response to topologically incorrect protein (GO:0035967)2.61495446
64pteridine-containing compound biosynthetic process (GO:0042559)2.61042917
65vesicle coating (GO:0006901)2.60603334
66negative regulation of glycogen biosynthetic process (GO:0045719)2.60169100
67regulation of Rac protein signal transduction (GO:0035020)2.58366134
68establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58154261
69regulation of helicase activity (GO:0051095)2.57621330
70DNA unwinding involved in DNA replication (GO:0006268)2.57117758
71IMP biosynthetic process (GO:0006188)2.56341223
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54275801
73fibroblast migration (GO:0010761)2.53916590
74protein localization to endoplasmic reticulum (GO:0070972)2.53290354
75DNA replication-dependent nucleosome assembly (GO:0006335)2.53134225
76DNA replication-dependent nucleosome organization (GO:0034723)2.53134225
77telomere maintenance via semi-conservative replication (GO:0032201)2.52424941
78acrosome assembly (GO:0001675)2.50693014
79cellular zinc ion homeostasis (GO:0006882)2.49432603
80chondrocyte proliferation (GO:0035988)2.49138122
81negative regulation of protein activation cascade (GO:2000258)2.48612297
82negative regulation of DNA repair (GO:0045738)2.46958661
83regulation of RIG-I signaling pathway (GO:0039535)2.46840873
84regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46370319
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44794755
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44794755
87negative regulation of glucose transport (GO:0010829)2.44297832
88zinc ion transmembrane transport (GO:0071577)2.44247124
89negative regulation by host of viral transcription (GO:0043922)2.43371445
90regulation of activation of Janus kinase activity (GO:0010533)2.42844756
91regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.41519292
92positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.41519292
93transcytosis (GO:0045056)2.40632327
94nephron tubule morphogenesis (GO:0072078)2.40589151
95nephron epithelium morphogenesis (GO:0072088)2.40589151
96IMP metabolic process (GO:0046040)2.38976749
97positive regulation of DNA-templated transcription, initiation (GO:2000144)2.38816833
98sequestering of extracellular ligand from receptor (GO:0035581)2.38465318
99regulation of posttranscriptional gene silencing (GO:0060147)2.38124175
100regulation of gene silencing by miRNA (GO:0060964)2.38124175
101regulation of gene silencing by RNA (GO:0060966)2.38124175
102viral transcription (GO:0019083)2.37971213
103cellular response to glucose starvation (GO:0042149)2.37842370
104translational termination (GO:0006415)2.37776338
105kinetochore organization (GO:0051383)2.37753285
106positive regulation of histone H3-K4 methylation (GO:0051571)2.36879448
107regulation of transforming growth factor beta2 production (GO:0032909)2.36459907
108telomere maintenance via recombination (GO:0000722)2.36217713
109ribosome biogenesis (GO:0042254)2.36086198
110kinetochore assembly (GO:0051382)2.35809904
111translational initiation (GO:0006413)2.35593258
112positive regulation of organelle assembly (GO:1902117)2.35558528
113intestinal epithelial cell development (GO:0060576)2.35369322
114cell adhesion mediated by integrin (GO:0033627)2.35331566
115negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.34876931
116COPII vesicle coating (GO:0048208)2.34756544
117sister chromatid cohesion (GO:0007062)2.34694790
118natural killer cell mediated cytotoxicity (GO:0042267)2.34641983
119natural killer cell mediated immunity (GO:0002228)2.34641983
120glomerular basement membrane development (GO:0032836)2.34185754
121tetrahydrofolate metabolic process (GO:0046653)2.33441041
122wound healing, spreading of epidermal cells (GO:0035313)2.33345604
123response to UV-C (GO:0010225)2.33280431
124meiotic chromosome segregation (GO:0045132)2.33085019
125collagen fibril organization (GO:0030199)2.32757341
126histone H2A monoubiquitination (GO:0035518)2.32167022
127response to X-ray (GO:0010165)2.31830434
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30874773
129response to unfolded protein (GO:0006986)2.30657196
130embryonic digestive tract morphogenesis (GO:0048557)2.28722523
131energy homeostasis (GO:0097009)2.28460181
132response to endoplasmic reticulum stress (GO:0034976)2.27387673
133positive regulation of catenin import into nucleus (GO:0035413)2.27245052
134negative regulation of glycogen metabolic process (GO:0070874)2.27026986
135regulation of centriole replication (GO:0046599)2.26441857
136T-helper 1 type immune response (GO:0042088)2.26324082
137monoubiquitinated protein deubiquitination (GO:0035520)2.26142040
138negative regulation of neurological system process (GO:0031645)2.25989181
139ribonucleoprotein complex biogenesis (GO:0022613)2.25709924
140nuclear envelope organization (GO:0006998)2.25448891
141negative regulation of metanephros development (GO:0072217)2.25151540
142regulation of centrosome duplication (GO:0010824)2.25080594
143positive regulation of p38MAPK cascade (GO:1900745)2.24575375
144keratan sulfate catabolic process (GO:0042340)2.23969120
145intra-S DNA damage checkpoint (GO:0031573)2.23428671
146mitotic sister chromatid cohesion (GO:0007064)2.23231638
147rRNA modification (GO:0000154)2.22967936
148protein maturation by protein folding (GO:0022417)2.22676472
149DNA deamination (GO:0045006)2.22444641
150response to redox state (GO:0051775)2.22389636
151cellular response to ethanol (GO:0071361)2.21546482
152protein localization to chromosome, centromeric region (GO:0071459)2.21487906
153Leydig cell differentiation (GO:0033327)2.21309816
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.21282459
155ribosomal large subunit biogenesis (GO:0042273)2.20585353
156proteasome assembly (GO:0043248)2.20188348
157paraxial mesoderm development (GO:0048339)2.18131573
158mitotic recombination (GO:0006312)2.17432692
159rRNA processing (GO:0006364)2.17288621
160positive regulation of SMAD protein import into nucleus (GO:0060391)2.17245516
161ribosomal small subunit biogenesis (GO:0042274)2.16691718
162translational elongation (GO:0006414)2.16660941
163CENP-A containing nucleosome assembly (GO:0034080)2.15878704
164telomere maintenance via telomere lengthening (GO:0010833)2.15828745
165DNA replication-independent nucleosome assembly (GO:0006336)2.15510741
166DNA replication-independent nucleosome organization (GO:0034724)2.15510741
167interferon-gamma secretion (GO:0072643)2.14835220
168chromatin remodeling at centromere (GO:0031055)2.14713062
169attachment of spindle microtubules to kinetochore (GO:0008608)2.14622375
170positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.10891753
171regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.10625834
172rRNA metabolic process (GO:0016072)2.10513777
173neutrophil activation involved in immune response (GO:0002283)2.09209271
174nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.07654161
175spindle checkpoint (GO:0031577)2.07467352
176regulation of translation in response to stress (GO:0043555)2.07199866
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.07172087
178pore complex assembly (GO:0046931)2.07003822
179negative regulation of chromosome segregation (GO:0051985)2.05680210
180somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.05188844
181somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.05188844
182isotype switching (GO:0045190)2.05188844
183anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.04056524
184UDP-N-acetylglucosamine metabolic process (GO:0006047)2.03386937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91084132
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98402760
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.62260347
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.12425722
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.79722066
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71541364
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.55056040
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54403244
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.51243658
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48767664
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47438862
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46995019
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46082378
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.42552258
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39797097
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36940405
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25568469
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18555081
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18305585
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18100330
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17741475
22* ETS1_20019798_ChIP-Seq_JURKAT_Human2.17649302
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17340986
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09567080
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.06752356
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03756029
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03605363
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00465430
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96496928
30* VDR_23849224_ChIP-Seq_CD4+_Human1.96045132
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94963454
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94963454
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94963454
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.92342044
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.92247370
36BRD4_25478319_ChIP-Seq_HGPS_Human1.85958486
37XRN2_22483619_ChIP-Seq_HELA_Human1.85806773
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82882087
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82844721
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82167271
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79277248
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73720457
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71714283
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70312665
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69636240
46ELK1_19687146_ChIP-ChIP_HELA_Human1.68836580
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.68466438
48TFEB_21752829_ChIP-Seq_HELA_Human1.68091269
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67519480
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66753812
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64379085
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.64255714
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63385541
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62661810
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57897357
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57262733
57AR_21909140_ChIP-Seq_LNCAP_Human1.56970428
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.54367885
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49519800
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48370556
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47974033
62FOXP3_21729870_ChIP-Seq_TREG_Human1.47226821
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46358381
64* IRF8_21731497_ChIP-ChIP_J774_Mouse1.45702079
65* GABP_19822575_ChIP-Seq_HepG2_Human1.45023263
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44295579
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43655636
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.42400094
69CJUN_26792858_Chip-Seq_BT549_Human1.41222423
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40296247
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39831680
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38453570
73TTF2_22483619_ChIP-Seq_HELA_Human1.37699979
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36782881
75KDM5A_27292631_Chip-Seq_BREAST_Human1.36753028
76EWS_26573619_Chip-Seq_HEK293_Human1.35930480
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35549802
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35369378
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34991377
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34103195
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33305124
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32911832
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32021741
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31885143
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30327292
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27887410
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27887410
88CLOCK_20551151_ChIP-Seq_293T_Human1.27457579
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27089718
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26603566
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26343234
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.23727134
93* SPI1_23547873_ChIP-Seq_NB4_Human1.22124828
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21505397
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21505397
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21139657
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19457006
98CIITA_25753668_ChIP-Seq_RAJI_Human1.19097780
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19088305
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18640071
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17606787
102CDX2_22108803_ChIP-Seq_LS180_Human1.17154851
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.17037205
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15678540
105* MYC_22102868_ChIP-Seq_BL_Human1.14939567
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14765245
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14033031
108FUS_26573619_Chip-Seq_HEK293_Human1.13454624
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12545851
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.12447819
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10914285
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.10880464
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09522882
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08743457
115* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08150843
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07661614
117* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07570177
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06766899
119* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06701690
120SOX17_20123909_ChIP-Seq_XEN_Mouse1.06625280
121ZNF274_21170338_ChIP-Seq_K562_Hela1.06358635
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04526636
123ELK1_22589737_ChIP-Seq_MCF10A_Human1.03847227
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03314377
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03070975
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03040390
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.02355659
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02215664
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01825353
130* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01295413
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01284471
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99418436
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98953961
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98506537
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.98256904
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97757728
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.97700474
138* YY1_21170310_ChIP-Seq_MESCs_Mouse0.97699282
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97562577
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96853680
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96201407
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96141474
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95384749
144* NANOG_21062744_ChIP-ChIP_HESCs_Human0.95353186
145ELF5_23300383_ChIP-Seq_T47D_Human0.95217798
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95191760
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94863755
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94662715
149P300_19829295_ChIP-Seq_ESCs_Human0.94620435
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94267770
151TP53_18474530_ChIP-ChIP_U2OS_Human0.93546525
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92492239
153* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91753588
154NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91173960
155* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90668815
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90266634
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89957130
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.89077318
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88436474
160ER_23166858_ChIP-Seq_MCF-7_Human0.88114939
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86193448
162TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85053281
163BCAT_22108803_ChIP-Seq_LS180_Human0.83290915
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.82655415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.57980056
2MP0003693_abnormal_embryo_hatching3.37039731
3MP0008057_abnormal_DNA_replication3.36404755
4MP0003950_abnormal_plasma_membrane3.00250904
5MP0004272_abnormal_basement_membrane2.92895633
6MP0004957_abnormal_blastocyst_morpholog2.66397250
7MP0002139_abnormal_hepatobiliary_system2.33371753
8MP0010094_abnormal_chromosome_stability2.32459294
9MP0003077_abnormal_cell_cycle2.29526964
10MP0010352_gastrointestinal_tract_polyps2.27037110
11MP0003195_calcinosis2.24184938
12MP0002163_abnormal_gland_morphology2.15975836
13MP0003111_abnormal_nucleus_morphology2.10262095
14MP0008007_abnormal_cellular_replicative1.83183456
15MP0009780_abnormal_chondrocyte_physiolo1.79019077
16MP0002877_abnormal_melanocyte_morpholog1.78315783
17MP0010234_abnormal_vibrissa_follicle1.71256602
18MP0003656_abnormal_erythrocyte_physiolo1.71004372
19MP0008058_abnormal_DNA_repair1.67922776
20MP0010368_abnormal_lymphatic_system1.65317152
21MP0002060_abnormal_skin_morphology1.64392120
22MP0005503_abnormal_tendon_morphology1.63808141
23MP0005076_abnormal_cell_differentiation1.63379372
24MP0008438_abnormal_cutaneous_collagen1.62758254
25MP0008932_abnormal_embryonic_tissue1.61470611
26MP0003123_paternal_imprinting1.60278090
27MP0001835_abnormal_antigen_presentation1.59762197
28MP0001348_abnormal_lacrimal_gland1.59107424
29MP0004264_abnormal_extraembryonic_tissu1.56720092
30MP0002295_abnormal_pulmonary_circulatio1.55204332
31MP0005379_endocrine/exocrine_gland_phen1.51257276
32MP0000685_abnormal_immune_system1.50962024
33MP0000350_abnormal_cell_proliferation1.49865927
34MP0002396_abnormal_hematopoietic_system1.48300735
35MP0005408_hypopigmentation1.45647306
36MP0002938_white_spotting1.43208181
37MP0001346_abnormal_lacrimal_gland1.43118861
38MP0001293_anophthalmia1.41470734
39MP0010030_abnormal_orbit_morphology1.39196665
40MP0000613_abnormal_salivary_gland1.37023625
41MP0001661_extended_life_span1.36910865
42MP0003283_abnormal_digestive_organ1.34806992
43MP0002148_abnormal_hypersensitivity_rea1.34377028
44MP0002006_tumorigenesis1.33902451
45MP0002168_other_aberrant_phenotype1.32565640
46MP0001730_embryonic_growth_arrest1.30989546
47MP0003941_abnormal_skin_development1.30581024
48MP0010678_abnormal_skin_adnexa1.27776049
49MP0003566_abnormal_cell_adhesion1.26685143
50MP0003436_decreased_susceptibility_to1.25058630
51MP0001853_heart_inflammation1.21550332
52MP0009333_abnormal_splenocyte_physiolog1.20728230
53MP0005395_other_phenotype1.20056549
54MP0002166_altered_tumor_susceptibility1.19796194
55MP0010307_abnormal_tumor_latency1.19601328
56MP0006054_spinal_hemorrhage1.19501987
57MP0000516_abnormal_urinary_system1.19358280
58MP0005367_renal/urinary_system_phenotyp1.19358280
59MP0003279_aneurysm1.19328216
60MP0001915_intracranial_hemorrhage1.18481740
61MP0003172_abnormal_lysosome_physiology1.16172560
62MP0003718_maternal_effect1.15276227
63MP0005671_abnormal_response_to1.15035928
64MP0001672_abnormal_embryogenesis/_devel1.14438482
65MP0005380_embryogenesis_phenotype1.14438482
66MP0002138_abnormal_hepatobiliary_system1.14109038
67MP0002277_abnormal_respiratory_mucosa1.13890669
68MP0001697_abnormal_embryo_size1.12529760
69MP0003890_abnormal_embryonic-extraembry1.12522992
70MP0006072_abnormal_retinal_apoptosis1.11874983
71MP0004133_heterotaxia1.11763197
72MP0002085_abnormal_embryonic_tissue1.11217630
73MP0002009_preneoplasia1.10546536
74MP0005360_urolithiasis1.10240784
75MP0002084_abnormal_developmental_patter1.09829047
76MP0005220_abnormal_exocrine_pancreas1.09588338
77MP0009785_altered_susceptibility_to1.09438968
78MP0003121_genomic_imprinting1.07912769
79MP0003984_embryonic_growth_retardation1.07809012
80MP0000013_abnormal_adipose_tissue1.07714520
81MP0002088_abnormal_embryonic_growth/wei1.06069387
82MP0000858_altered_metastatic_potential1.05660186
83MP0000490_abnormal_crypts_of1.04425501
84MP0005084_abnormal_gallbladder_morpholo1.02206281
85MP0004197_abnormal_fetal_growth/weight/1.01957814
86MP0002086_abnormal_extraembryonic_tissu1.01377793
87MP0005023_abnormal_wound_healing1.01131785
88MP0003448_altered_tumor_morphology1.00969566
89MP0005000_abnormal_immune_tolerance0.98862709
90MP0000678_abnormal_parathyroid_gland0.98713335
91MP0000383_abnormal_hair_follicle0.98333552
92MP0005508_abnormal_skeleton_morphology0.97146801
93MP0003045_fibrosis0.96569435
94MP0008877_abnormal_DNA_methylation0.95911610
95MP0003806_abnormal_nucleotide_metabolis0.95489027
96MP0002080_prenatal_lethality0.95176208
97MP0002019_abnormal_tumor_incidence0.93668010
98MP0003868_abnormal_feces_composition0.93539576
99MP0003937_abnormal_limbs/digits/tail_de0.92914015
100MP0005310_abnormal_salivary_gland0.92654785
101MP0000313_abnormal_cell_death0.90919070
102MP0004084_abnormal_cardiac_muscle0.90261486
103MP0003705_abnormal_hypodermis_morpholog0.90069347
104MP0001879_abnormal_lymphatic_vessel0.89508276
105MP0000538_abnormal_urinary_bladder0.88773520
106MP0001542_abnormal_bone_strength0.88617824
107MP0002452_abnormal_antigen_presenting0.88603924
108MP0009697_abnormal_copulation0.87980395
109MP0003786_premature_aging0.87358781
110MP0001790_abnormal_immune_system0.86581036
111MP0005387_immune_system_phenotype0.86581036
112MP0002693_abnormal_pancreas_physiology0.86189067
113MP0003186_abnormal_redox_activity0.86127873
114MP0002933_joint_inflammation0.86066637
115MP0001800_abnormal_humoral_immune0.84614103
116MP0005390_skeleton_phenotype0.83565711
117MP0002398_abnormal_bone_marrow0.83284158
118MP0002723_abnormal_immune_serum0.83259438
119MP0002405_respiratory_system_inflammati0.83149723
120MP0000767_abnormal_smooth_muscle0.82760737
121MP0000428_abnormal_craniofacial_morphol0.82386025
122MP0003755_abnormal_palate_morphology0.82115147
123MP0000733_abnormal_muscle_development0.81897447
124MP0001545_abnormal_hematopoietic_system0.81480658
125MP0005397_hematopoietic_system_phenotyp0.81480658
126MP0003567_abnormal_fetal_cardiomyocyte0.81425268
127MP0005275_abnormal_skin_tensile0.81377419
128MP0000003_abnormal_adipose_tissue0.81340866
129MP0005025_abnormal_response_to0.80418593
130MP0002282_abnormal_trachea_morphology0.79482660
131MP0009053_abnormal_anal_canal0.79321434
132MP0004808_abnormal_hematopoietic_stem0.79251685
133MP0001286_abnormal_eye_development0.78868175
134MP0004036_abnormal_muscle_relaxation0.78484869
135MP0005257_abnormal_intraocular_pressure0.78239375
136MP0001216_abnormal_epidermal_layer0.77467417
137MP0001191_abnormal_skin_condition0.76504653
138MP0001243_abnormal_dermal_layer0.76431510
139MP0001819_abnormal_immune_cell0.76293102
140MP0000566_synostosis0.76082076
141MP0008775_abnormal_heart_ventricle0.75481508
142MP0000427_abnormal_hair_cycle0.75365630
143MP0002896_abnormal_bone_mineralization0.75357360
144MP0001666_abnormal_nutrient_absorption0.74043659
145MP0001299_abnormal_eye_distance/0.73968533
146MP0003936_abnormal_reproductive_system0.73481998
147MP0000432_abnormal_head_morphology0.72718514
148MP0002115_abnormal_skeleton_extremities0.71157560
149MP0002108_abnormal_muscle_morphology0.70019130
150MP0000639_abnormal_adrenal_gland0.69301058
151MP0009250_abnormal_appendicular_skeleto0.69187565
152MP0003091_abnormal_cell_migration0.68216983
153MP0001881_abnormal_mammary_gland0.68052550
154MP0002233_abnormal_nose_morphology0.67617110

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)3.81170618
2Glucose intolerance (HP:0000833)3.68665263
3Premature rupture of membranes (HP:0001788)3.63369999
4Azoospermia (HP:0000027)3.54477174
5Nonimmune hydrops fetalis (HP:0001790)3.45888753
6Birth length less than 3rd percentile (HP:0003561)3.13252111
7Abnormal pancreas size (HP:0012094)3.12117605
8Abnormal spermatogenesis (HP:0008669)2.85121558
9Breast hypoplasia (HP:0003187)2.82147680
10Flat capital femoral epiphysis (HP:0003370)2.81810172
11Aortic dissection (HP:0002647)2.77564158
12Proximal tubulopathy (HP:0000114)2.77028571
13Carpal bone hypoplasia (HP:0001498)2.68752451
14Abnormality of methionine metabolism (HP:0010901)2.68034360
15Abnormal glucose tolerance (HP:0001952)2.66858716
16Colon cancer (HP:0003003)2.61113158
17Abnormality of dentin (HP:0010299)2.50840774
18Soft skin (HP:0000977)2.50762644
19Type I transferrin isoform profile (HP:0003642)2.50633759
20Microglossia (HP:0000171)2.48203652
21Cortical dysplasia (HP:0002539)2.43113661
22Hypoplasia of the uterus (HP:0000013)2.39560931
23Bifid tongue (HP:0010297)2.37982296
24Reticulocytopenia (HP:0001896)2.37063418
25Myocardial infarction (HP:0001658)2.36314130
26Popliteal pterygium (HP:0009756)2.36042729
27Entropion (HP:0000621)2.35591432
28Spondylolisthesis (HP:0003302)2.32516109
29Amaurosis fugax (HP:0100576)2.32411173
30Selective tooth agenesis (HP:0001592)2.32190234
31Cardiovascular calcification (HP:0011915)2.29322216
32Tubular atrophy (HP:0000092)2.28830952
33Abnormality of the intrinsic pathway (HP:0010989)2.27845999
34Hypobetalipoproteinemia (HP:0003563)2.26097800
35Degeneration of anterior horn cells (HP:0002398)2.25474429
36Abnormality of the anterior horn cell (HP:0006802)2.25474429
37Abdominal situs inversus (HP:0003363)2.24872962
38Abnormality of abdominal situs (HP:0011620)2.24872962
39Rough bone trabeculation (HP:0100670)2.24574235
40Hematochezia (HP:0002573)2.22713753
41Unilateral renal agenesis (HP:0000122)2.20877782
42Hydroxyprolinuria (HP:0003080)2.20252650
43Abnormality of proline metabolism (HP:0010907)2.20252650
44Fatigue (HP:0012378)2.19817225
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17488661
46Cervical subluxation (HP:0003308)2.16392467
47Absent radius (HP:0003974)2.15626841
48Gonadotropin excess (HP:0000837)2.14532405
49Abnormality of vitamin B metabolism (HP:0004340)2.13515587
50Stenosis of the external auditory canal (HP:0000402)2.12162930
51Thrombocytosis (HP:0001894)2.11227143
52Aplasia/hypoplasia of the humerus (HP:0006507)2.11025412
53Vascular calcification (HP:0004934)2.09091453
54Aplastic anemia (HP:0001915)2.07972258
55Irregular epiphyses (HP:0010582)2.06699070
56Hypokinesia (HP:0002375)2.05086032
57Megaloblastic anemia (HP:0001889)2.04935921
58Methylmalonic acidemia (HP:0002912)2.04474763
59Gout (HP:0001997)2.04132139
60Cutaneous melanoma (HP:0012056)2.03501825
61Chromsome breakage (HP:0040012)2.03422474
62Patellar aplasia (HP:0006443)2.02914383
63Abnormal delivery (HP:0001787)2.02764680
64Fused cervical vertebrae (HP:0002949)2.01234360
65Testicular atrophy (HP:0000029)2.01013615
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.00928335
67Optic nerve coloboma (HP:0000588)1.99395477
68Aplasia involving forearm bones (HP:0009822)1.96967191
69Absent forearm bone (HP:0003953)1.96967191
70Sparse lateral eyebrow (HP:0005338)1.96726116
71Cleft eyelid (HP:0000625)1.96529506
72Small epiphyses (HP:0010585)1.95473636
73Beaking of vertebral bodies (HP:0004568)1.94580191
74Homocystinuria (HP:0002156)1.93616530
75Abnormality of homocysteine metabolism (HP:0010919)1.93616530
76Ectopic kidney (HP:0000086)1.93553318
77Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92799110
78Abnormal glycosylation (HP:0012345)1.92603662
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92603662
80Abnormal protein N-linked glycosylation (HP:0012347)1.92603662
81Abnormal protein glycosylation (HP:0012346)1.92603662
82Short middle phalanx of the 5th finger (HP:0004220)1.92576099
83Tetraparesis (HP:0002273)1.91523252
84Poor head control (HP:0002421)1.91452970
85Disproportionate short-trunk short stature (HP:0003521)1.91266752
86Meckel diverticulum (HP:0002245)1.90922574
87Thoracolumbar scoliosis (HP:0002944)1.90580338
88Overlapping toe (HP:0001845)1.90175740
89Albinism (HP:0001022)1.89844340
90Abnormal trabecular bone morphology (HP:0100671)1.89001557
91Hypolipoproteinemia (HP:0010981)1.88242116
92Aplasia/Hypoplasia of the patella (HP:0006498)1.87452508
9311 pairs of ribs (HP:0000878)1.85203092
94Abnormality of the fetal cardiovascular system (HP:0010948)1.85174740
95Abnormal umbilical cord blood vessels (HP:0011403)1.85174740
96Single umbilical artery (HP:0001195)1.85174740
97Protrusio acetabuli (HP:0003179)1.84728724
98Short humerus (HP:0005792)1.84391937
99Medulloblastoma (HP:0002885)1.84125962
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83396428
101Metaphyseal dysplasia (HP:0100255)1.82824570
102Abnormality of the ileum (HP:0001549)1.81920306
103Spinal muscular atrophy (HP:0007269)1.80465330
104Supernumerary spleens (HP:0009799)1.79645355
105Breech presentation (HP:0001623)1.79340000
106Hyperinsulinemic hypoglycemia (HP:0000825)1.79095614
107Anal stenosis (HP:0002025)1.79094353
108Gastrointestinal infarctions (HP:0005244)1.79001011
109Abnormal sex determination (HP:0012244)1.78973741
110Sex reversal (HP:0012245)1.78973741
111Horizontal nystagmus (HP:0000666)1.78142814
112Trismus (HP:0000211)1.77842813
113Secondary amenorrhea (HP:0000869)1.77579203
114Atresia of the external auditory canal (HP:0000413)1.76437874
115Vascular tortuosity (HP:0004948)1.75819450
116Myelodysplasia (HP:0002863)1.75560034
117Lip pit (HP:0100267)1.75322560
118Abnormality of the umbilical cord (HP:0010881)1.75079811
119Increased IgM level (HP:0003496)1.74978915
120Abnormality of the pons (HP:0007361)1.74805132
121Curly hair (HP:0002212)1.74346469
122Abnormality of the proximal phalanges of the hand (HP:0009834)1.73986861
123Prolonged partial thromboplastin time (HP:0003645)1.73704849
124Vertebral compression fractures (HP:0002953)1.73213345
125Relative macrocephaly (HP:0004482)1.73131202
126Premature graying of hair (HP:0002216)1.72850859
127Agnosia (HP:0010524)1.72110564
128Abnormal number of incisors (HP:0011064)1.71589997
129Abnormal tarsal ossification (HP:0008369)1.71174367
130Ependymoma (HP:0002888)1.70528528
131Pterygium (HP:0001059)1.70477912
132Abnormality of the fingertips (HP:0001211)1.70394565
133Broad thumb (HP:0011304)1.70381322
134Deviation of the thumb (HP:0009603)1.70329524
135Missing ribs (HP:0000921)1.70277139
136Abnormality of DNA repair (HP:0003254)1.69191548
137Abnormal biliary tract physiology (HP:0012439)1.69051082
138Bile duct proliferation (HP:0001408)1.69051082
139Hypoplasia of the pons (HP:0012110)1.68331346
140Long eyelashes (HP:0000527)1.68252180
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.66989584
142Volvulus (HP:0002580)1.66829960
143Eczematoid dermatitis (HP:0000976)1.66275569
144Neoplasm of the oral cavity (HP:0100649)1.66266360
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66019450
146Bone marrow hypocellularity (HP:0005528)1.65914154
147Hypoplastic labia majora (HP:0000059)1.65424978
148Aortic valve stenosis (HP:0001650)1.64832829
149Methylmalonic aciduria (HP:0012120)1.64016036
150Natal tooth (HP:0000695)1.63905144
151Recurrent abscess formation (HP:0002722)1.63408046
152Oral leukoplakia (HP:0002745)1.62876565
153Recurrent bacterial skin infections (HP:0005406)1.62805814
154Vertebral clefting (HP:0008428)1.61619261
155Limited elbow extension (HP:0001377)1.61308346
156Hypoplasia of the radius (HP:0002984)1.61136332
157Hypoglycemic seizures (HP:0002173)1.60991617
158Abnormal foot bone ossification (HP:0010675)1.60778585
159Abnormal biliary tract morphology (HP:0012440)1.60776305
160Intestinal atresia (HP:0011100)1.60534109
161Hypoalbuminemia (HP:0003073)1.59997052
162Abnormal albumin level (HP:0012116)1.59997052
163Prostate neoplasm (HP:0100787)1.59910436
164Arterial tortuosity (HP:0005116)1.59634796
165Epiphyseal dysplasia (HP:0002656)1.58695271
166Neoplasm of the pancreas (HP:0002894)1.58552359
167Mediastinal lymphadenopathy (HP:0100721)1.57649888
168Acute myeloid leukemia (HP:0004808)1.57603630
169Reduced antithrombin III activity (HP:0001976)1.57360422
170Abnormality of chromosome stability (HP:0003220)1.56889146
171Adactyly (HP:0009776)1.56622555
172Abnormality of the labia majora (HP:0012881)1.56482459
173Hypophosphatemic rickets (HP:0004912)1.55893416
174Short 4th metacarpal (HP:0010044)1.55422331
175Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55422331
176Premature ovarian failure (HP:0008209)1.55306700
177Increased CSF protein (HP:0002922)1.55112231
178Astrocytoma (HP:0009592)1.54471336
179Abnormality of the astrocytes (HP:0100707)1.54471336
180Shawl scrotum (HP:0000049)1.53978712
181Abnormality of vitamin metabolism (HP:0100508)1.53523838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.60067394
2BUB12.53636593
3WEE12.45679440
4STK242.42911275
5PASK2.40606245
6FLT32.39658833
7ACVR1B2.33066522
8RPS6KA42.29570361
9EIF2AK12.14143158
10CDK122.13667850
11EIF2AK32.08773773
12ERBB42.03338411
13FER1.97137820
14MAP3K141.94459938
15JAK31.93170524
16PDK21.89534538
17CDC71.83620406
18IKBKB1.83426269
19NME21.82838118
20EPHA21.81807266
21BRSK21.80857217
22AKT31.76386950
23DYRK31.75653453
24CHUK1.73056119
25EPHA31.61562130
26TRIM281.55329586
27NEK21.54884582
28PIM21.52472692
29TTK1.52399699
30PNCK1.51446563
31ERN11.51266725
32NUAK11.50646933
33PLK41.48960675
34MAP3K121.47430449
35CDK71.46149841
36TYK21.45340624
37BRSK11.44226825
38MUSK1.40679934
39PLK21.35109046
40NEK91.34539270
41SIK31.34141255
42IRAK41.32914206
43STK31.31481380
44VRK11.28866822
45ATR1.28268193
46PLK11.25957068
47TRPM71.24242058
48STK41.23957190
49TESK21.23198034
50GRK11.22617458
51CAMKK21.21428110
52TAOK31.19513566
53CAMK1G1.17279621
54PBK1.17099924
55CHEK21.16917904
56SRPK11.16871651
57MET1.16347423
58PIM11.14272702
59MAP3K81.13235148
60INSRR1.12507236
61BCR1.12255823
62MYLK1.09101594
63PKN21.07101840
64IRAK31.06776305
65LATS11.06377314
66BRD41.06333607
67ZAK1.05673671
68STK101.05634993
69RPS6KB21.05626192
70STK161.04910201
71PIK3CG1.04270672
72TSSK61.03288325
73TBK11.00901025
74MST1R0.99932087
75FGFR10.99065921
76AURKB0.98169259
77TEC0.97950504
78TGFBR10.93466316
79TGFBR20.92865011
80TLK10.92639884
81PLK30.92492264
82MAP3K130.91990557
83EIF2AK20.90630180
84NLK0.89298011
85WNK30.88634102
86TNIK0.87848063
87RPS6KA50.87610394
88KIT0.86950389
89CHEK10.86907187
90STK390.85690834
91CDK40.84688615
92MELK0.84566401
93ERBB30.83799237
94MKNK10.79123456
95TAF10.78680429
96PRKCE0.75488493
97DYRK20.74589419
98MAPK150.72590001
99MST40.72491445
100PTK20.71621698
101STK38L0.71590214
102MTOR0.70325693
103FGFR30.69869612
104BRAF0.69321955
105TESK10.68224426
106IKBKE0.67833326
107CDK60.64861442
108HIPK20.64857392
109ATM0.64467270
110CSF1R0.63967992
111NME10.63942934
112IRAK10.61794177
113DDR20.61178815
114PAK40.61076987
115PAK30.59972191
116MAPKAPK20.58287800
117AURKA0.57417937
118GRK70.57354571
119MKNK20.56786124
120CDK20.55399831
121YES10.55152148
122FGFR20.54344571
123IRAK20.54259604
124MAP2K60.52554008
125MAP3K30.52274112
126LRRK20.51979684
127KDR0.51521913
128PAK10.51002452
129BTK0.50641412
130CSNK2A10.50027938
131FGFR40.49845867
132MAP4K20.49411884
133SCYL20.48145177
134CDK80.47925418
135ZAP700.47792468
136BMPR1B0.46836713
137MARK30.44526483
138PRKAA20.43940150
139JAK10.43480877
140CSNK2A20.43472211
141GSK3A0.42782230
142PDGFRA0.42585822
143EPHB10.42145458
144BMPR20.40689064
145WNK40.40576879
146PTK2B0.40371847
147MAP3K40.38294162
148IGF1R0.37897164
149TIE10.37554594
150WNK10.37062216

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.08780537
2DNA replication_Homo sapiens_hsa030303.08398728
3Sulfur metabolism_Homo sapiens_hsa009202.72773390
4Mismatch repair_Homo sapiens_hsa034302.70898850
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54744707
6RNA polymerase_Homo sapiens_hsa030202.35742599
7One carbon pool by folate_Homo sapiens_hsa006702.32091900
8Proteasome_Homo sapiens_hsa030502.31265927
9Ribosome_Homo sapiens_hsa030102.26047384
10RNA transport_Homo sapiens_hsa030132.24267430
11Homologous recombination_Homo sapiens_hsa034402.13016620
12Cell cycle_Homo sapiens_hsa041102.11531294
13Spliceosome_Homo sapiens_hsa030402.04221517
14Base excision repair_Homo sapiens_hsa034102.00966431
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.97689038
16Allograft rejection_Homo sapiens_hsa053301.96524286
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86582066
18Circadian rhythm_Homo sapiens_hsa047101.85973059
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85575607
20Nucleotide excision repair_Homo sapiens_hsa034201.82201882
21Basal transcription factors_Homo sapiens_hsa030221.71548828
22p53 signaling pathway_Homo sapiens_hsa041151.70288458
23Propanoate metabolism_Homo sapiens_hsa006401.68184672
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.66715594
25Folate biosynthesis_Homo sapiens_hsa007901.65979248
26Non-homologous end-joining_Homo sapiens_hsa034501.62067270
27Pyrimidine metabolism_Homo sapiens_hsa002401.57907709
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57180596
29Fanconi anemia pathway_Homo sapiens_hsa034601.53934695
30Herpes simplex infection_Homo sapiens_hsa051681.51497758
31Antigen processing and presentation_Homo sapiens_hsa046121.47518435
32Steroid biosynthesis_Homo sapiens_hsa001001.47212510
33Type I diabetes mellitus_Homo sapiens_hsa049401.44704841
34Legionellosis_Homo sapiens_hsa051341.43880122
35RNA degradation_Homo sapiens_hsa030181.42366343
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.37646542
37Graft-versus-host disease_Homo sapiens_hsa053321.34190226
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34088795
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.32899131
40Sphingolipid metabolism_Homo sapiens_hsa006001.29517758
41Epstein-Barr virus infection_Homo sapiens_hsa051691.26028826
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25095152
43Fatty acid elongation_Homo sapiens_hsa000621.21345504
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20031599
45Measles_Homo sapiens_hsa051621.14829067
46Complement and coagulation cascades_Homo sapiens_hsa046101.09765071
47Selenocompound metabolism_Homo sapiens_hsa004501.08159979
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.04674287
49Leishmaniasis_Homo sapiens_hsa051401.04383858
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03809568
51Viral carcinogenesis_Homo sapiens_hsa052031.03662752
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00628527
53Lysine degradation_Homo sapiens_hsa003100.98209783
54Autoimmune thyroid disease_Homo sapiens_hsa053200.97592338
55Small cell lung cancer_Homo sapiens_hsa052220.95034205
56Apoptosis_Homo sapiens_hsa042100.92385178
57Mineral absorption_Homo sapiens_hsa049780.92294008
58Influenza A_Homo sapiens_hsa051640.90330342
59HTLV-I infection_Homo sapiens_hsa051660.88784406
60TNF signaling pathway_Homo sapiens_hsa046680.88549266
61MicroRNAs in cancer_Homo sapiens_hsa052060.88261958
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.87933583
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86399897
64TGF-beta signaling pathway_Homo sapiens_hsa043500.85484634
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85395504
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83599554
67mRNA surveillance pathway_Homo sapiens_hsa030150.83350255
68Vitamin digestion and absorption_Homo sapiens_hsa049770.80535005
69Asthma_Homo sapiens_hsa053100.79312887
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79227576
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78004034
72Malaria_Homo sapiens_hsa051440.73613771
73N-Glycan biosynthesis_Homo sapiens_hsa005100.73329996
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72486221
75Purine metabolism_Homo sapiens_hsa002300.71484036
76Other glycan degradation_Homo sapiens_hsa005110.71133786
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70501199
78Fatty acid metabolism_Homo sapiens_hsa012120.69565966
79Toxoplasmosis_Homo sapiens_hsa051450.68574394
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.67755479
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66154657
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65599388
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64963001
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64922901
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64749392
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64540443
87Hepatitis B_Homo sapiens_hsa051610.61356148
88Tryptophan metabolism_Homo sapiens_hsa003800.60478175
89Prostate cancer_Homo sapiens_hsa052150.60288215
90Notch signaling pathway_Homo sapiens_hsa043300.59986062
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58376171
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57566323
93Renin-angiotensin system_Homo sapiens_hsa046140.56938862
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56671527
95Vitamin B6 metabolism_Homo sapiens_hsa007500.56149881
96Shigellosis_Homo sapiens_hsa051310.55729958
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55453350
98Ether lipid metabolism_Homo sapiens_hsa005650.55246445
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54147518
100Thyroid hormone synthesis_Homo sapiens_hsa049180.54002807
101Hippo signaling pathway_Homo sapiens_hsa043900.53857530
102Systemic lupus erythematosus_Homo sapiens_hsa053220.53804755
103Lysosome_Homo sapiens_hsa041420.52990449
104Viral myocarditis_Homo sapiens_hsa054160.52767823
105Basal cell carcinoma_Homo sapiens_hsa052170.51648689
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50239261
107Hematopoietic cell lineage_Homo sapiens_hsa046400.49998120
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49140492
109Adherens junction_Homo sapiens_hsa045200.48855037
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48723505
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48362887
112Protein digestion and absorption_Homo sapiens_hsa049740.48171266
113Hedgehog signaling pathway_Homo sapiens_hsa043400.47075807
114Thyroid cancer_Homo sapiens_hsa052160.46652339
115Retinol metabolism_Homo sapiens_hsa008300.46172824
116Vibrio cholerae infection_Homo sapiens_hsa051100.44745057
117Chronic myeloid leukemia_Homo sapiens_hsa052200.44703896
118Nitrogen metabolism_Homo sapiens_hsa009100.44701777
119Wnt signaling pathway_Homo sapiens_hsa043100.44450113
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44380111
121Pathways in cancer_Homo sapiens_hsa052000.44225431
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43842958
123Acute myeloid leukemia_Homo sapiens_hsa052210.43569385
124ECM-receptor interaction_Homo sapiens_hsa045120.42830290
125Pertussis_Homo sapiens_hsa051330.42703995
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42007757
127Fatty acid degradation_Homo sapiens_hsa000710.41886681
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41252271
129Focal adhesion_Homo sapiens_hsa045100.39469004
130Primary immunodeficiency_Homo sapiens_hsa053400.37616130
131Metabolic pathways_Homo sapiens_hsa011000.37430121
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36185854
133Proteoglycans in cancer_Homo sapiens_hsa052050.35851585
134Arachidonic acid metabolism_Homo sapiens_hsa005900.35581440
135Glutathione metabolism_Homo sapiens_hsa004800.33715853
136Bladder cancer_Homo sapiens_hsa052190.33265413
137Regulation of autophagy_Homo sapiens_hsa041400.32828463
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32714258
139Hepatitis C_Homo sapiens_hsa051600.32557093
140Galactose metabolism_Homo sapiens_hsa000520.31594398
141Osteoclast differentiation_Homo sapiens_hsa043800.31307915
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30164421
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29668421

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